LCPD
MCID: LGG001
MIFTS: 58

Legg-Calve-Perthes Disease (LCPD)

Categories: Blood diseases, Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Legg-Calve-Perthes Disease

MalaCards integrated aliases for Legg-Calve-Perthes Disease:

Name: Legg-Calve-Perthes Disease 56 12 52 58 73 36 13 43 15 39 71
Perthes Disease 56 12 52 25 58 73 54
Coxa Plana 12 52 25 29 6 32
Lcpd 56 52 25 73
Juvenile Osteochondrosis of Hip and Pelvis 12 32
Legg-Perthes Disease 56 73
Pseudocoxalgia 12 32
Avascular Necrosis of the Capital Femoral Epiphysis 71
Aseptic Necrosis of the Capital Femoral Epiphysis 58
Osteochondrosis of the Capital Femoral Epiphysis 58
Juvenile Osteochondrosis of Hip and/or Pelvis 12
Osteochondrosis of Legg-Calve-Perthes 12
Juvenile Osteochond-Hip/pelvis 12
Legg-Calvé-Perthes Syndrome 74
Legg-Calve-Perthes Syndrome 52
Legg-Calve-Perthes Symptom 12
Legg-Calvé-Perthes Disease 25
Osteochondritis Deformans 52
Calve - Perthes' Disease 12
Calve-Perthes Disease 25
Perthe's Disease 12
Lcp 56

Characteristics:

Orphanet epidemiological data:

58
legg-calve-perthes disease
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

OMIM:

56
Inheritance:
autosomal dominant vs. multifactorial


HPO:

31
legg-calve-perthes disease:
Inheritance autosomal dominant inheritance multifactorial inheritance


Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:14415
OMIM 56 150600
KEGG 36 H01526
MeSH 43 D007873
NCIt 49 C34766
SNOMED-CT 67 15739006
ICD10 via Orphanet 33 M91.1
UMLS via Orphanet 72 C0023234
Orphanet 58 ORPHA2380
MedGen 41 C0023234
UMLS 71 C0022441 C0023234 C1442965

Summaries for Legg-Calve-Perthes Disease

NIH Rare Diseases : 52 Legg-Calve-Perthes disease (LCPD) occurs when blood supply to the ball of the thighbone in the hip (femoral head) is disrupted. Without an adequate blood supply, the bone cells die. LCPD usually occurs in children between the ages of 4 and 10. Early symptoms may include limping; pain in the hip, thigh or knee; and reduced range of hip motion. Later in the disease course, there may be leg length discrepancy (one leg longer than the other) and wasting of the muscles around the hip. The condition can last for several years before new bone formation (re-ossification) and eventual healing occurs. Some people with LCPD go on to develop degenerative arthritis in adulthood. The underlying cause of LCPD is often not known. Sometimes it results from a slipped capital femoral epiphysis , trauma, steroid use, sickle-cell crisis, toxic synovitis , or congenital hip dysplasia . It usually is not caused by genetic factors, but a few familial cases with autosomal dominant inheritance have been reported. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible. Treatment aims to keep the thigh bone inside the hip socket. Treatment options may include rest or medication for pain; physical therapy ; using a brace; or surgery.

MalaCards based summary : Legg-Calve-Perthes Disease, also known as perthes disease, is related to osteonecrosis and factor v leiden thrombophilia. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Focal adhesion and ECM-receptor interaction. The drugs Tocopherol and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include hip joint, bone and testes, and related phenotypes are joint dislocation and delayed skeletal maturation

Disease Ontology : 12 An osteochondrosis that results in death and fracture located in hip joint.

Genetics Home Reference : 25 Legg-Calvé-Perthes disease is a bone disorder that affects the hips. Usually, only one hip is involved, but in about 10 percent of cases, both hips are affected. Legg-Calvé-Perthes disease begins in childhood, typically between ages 4 and 8, and affects boys more frequently than girls. In this condition, the upper end of the thigh bone, known as the femoral head, breaks down. As a result, the femoral head is no longer round and does not move easily in the hip socket, which leads to hip pain, limping, and restricted leg movement. The bone eventually begins to heal itself through a normal process called bone remodeling, by which old bone is removed and new bone is created to replace it. This cycle of breakdown and healing can recur multiple times. Affected individuals are often shorter than their peers due to the bone abnormalities. Many people with Legg-Calvé-Perthes disease go on to develop a painful joint disorder called osteoarthritis in the hips at an early age.

OMIM : 56 Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone. The disease occurs more frequently in boys, and most patients tend to be shorter than their peers. Both familial and isolated cases of LCPD have been reported (summary by Chen et al., 2004). (150600)

KEGG : 36 Legg-Calve-Perthes disease (LCPD) is a particular type of femoral head necrosis occurring in children. It is more common among boys, and bilateral involvement occurs in 8-24% of cases. The disease is usually diagnosed among children under age 14 years, with a peak onset between 5 and 8 years of age. There is delayed skeletal maturation and impaired growth. In addition to congenital abnormalities, LCPD is associated with greater risk of cardiovascular diseases and diseases of the blood. Most cases are sporadic, but familial cases have been described. It has been reported that COL2A1 mutations are associated with this disease.

UniProtKB/Swiss-Prot : 73 Legg-Calve-Perthes disease: Characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Wikipedia : 74 Legg-Calve-Perthes disease (LCPD), is a childhood hip disorder initiated by a disruption of blood flow... more...

Related Diseases for Legg-Calve-Perthes Disease

Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 334)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 31.0 SERPINE1 SERPINC1 MTHFR COL2A1
2 factor v leiden thrombophilia 30.5 MTHFR F5
3 spondyloepiphyseal dysplasia congenita 30.0 GALNS COL2A1
4 spondyloepiphyseal dysplasia with congenital joint dislocations 29.9 SLC26A2 GALNS COL2A1
5 vasculitis 29.6 THBD SELP SELE CD40LG APOH
6 purpura 29.5 THBD SERPINC1 SELP CD40LG APOH
7 protein s deficiency 29.4 THBD SERPINE1 SERPINC1 MTHFR F5 APOH
8 protein c deficiency 29.4 THBD SERPINE1 SERPINC1 MTHFR F5 APOH
9 thrombophilia due to thrombin defect 29.4 THBD SERPINE1 SERPINC1 MTHFR F5 APOH
10 pulmonary embolism 29.0 THBD SERPINE1 SERPINC1 MTHFR F5 CD40LG
11 thrombophilia 29.0 THBD SERPINE1 SERPINC1 SELP MTHFR F5
12 thrombophlebitis 28.7 SERPINE1 SERPINC1 SELP MTHFR F5 CD40LG
13 thrombocytopenia 28.7 THBD SERPINE1 SERPINC1 SELP SELE F5
14 thrombosis 28.3 THBD SERPINE1 SERPINC1 SELP SELE MTHFR
15 vascular disease 27.8 THBD SERPINE1 SERPINC1 SELP SELE MTHFR
16 osteoporosis 27.7 SLC26A2 SERPINE1 SERPINC1 SELE MTHFR IGFBP3
17 antiphospholipid syndrome 27.5 THBD SERPINE1 SERPINC1 SELP SELE MTHFR
18 arthrogryposis, perthes disease, and upward gaze palsy 12.7
19 endosteal hyperostosis, autosomal dominant 11.7
20 osteomesopyknosis 11.7
21 avascular necrosis of femoral head, primary, 1 11.7
22 familial avascular necrosis of the femoral head 11.7
23 garret tripp syndrome 11.3
24 avascular necrosis 11.0
25 upington disease 10.9
26 idiopathic avascular necrosis 10.8
27 osteochondrosis 10.7
28 overgrowth syndrome 10.7
29 osteochondritis dissecans 10.6
30 fibrinolytic defect 10.5 SERPINE1 SERPINC1
31 bone resorption disease 10.5
32 synovitis 10.5
33 osteoarthritis 10.5
34 cardiac tuberculosis 10.5 SERPINE1 SERPINC1
35 dic in newborn 10.5 SERPINE1 SERPINC1
36 syphilitic meningitis 10.5 SERPINC1 CD40LG
37 heparin-induced thrombocytopenia 10.5 SERPINC1 CD40LG
38 fournier gangrene 10.5 SERPINC1 CD40LG
39 multiple epiphyseal dysplasia 10.4
40 puerperal pulmonary embolism 10.4 SERPINC1 APOH
41 hepatic infarction 10.4 SERPINC1 APOH
42 volkmann contracture 10.4 SERPINC1 CD40LG
43 raynaud phenomenon 10.4 THBD APOH
44 platelet aggregation, spontaneous 10.4 SERPINC1 SELP
45 heterophyiasis 10.4 SELE CD40LG
46 argentine hemorrhagic fever 10.4 SERPINE1 SERPINC1
47 may-thurner syndrome 10.4 F5 APOH
48 viral exanthem 10.4 CD40LG APOH
49 erythema infectiosum 10.3 CD40LG APOH
50 acanthamoeba keratitis 10.3 F5 APOH

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to Legg-Calve-Perthes Disease

Symptoms & Phenotypes for Legg-Calve-Perthes Disease

Human phenotypes related to Legg-Calve-Perthes Disease:

58 31 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint dislocation 58 31 hallmark (90%) Very frequent (99-80%) HP:0001373
2 delayed skeletal maturation 58 31 hallmark (90%) Very frequent (99-80%) HP:0002750
3 abnormality of the dentition 58 31 hallmark (90%) Very frequent (99-80%) HP:0000164
4 short stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0004322
5 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
6 skeletal muscle atrophy 58 31 hallmark (90%) Very frequent (99-80%) HP:0003202
7 cartilage destruction 58 31 hallmark (90%) Very frequent (99-80%) HP:0100773
8 avascular necrosis 31 hallmark (90%) HP:0010885
9 aseptic necrosis 58 Very frequent (99-80%)
10 avascular necrosis of the capital femoral epiphysis 31 HP:0005743

Symptoms via clinical synopsis from OMIM:

56
Growth:
short stature

Limbs:
painful limp

Misc:
onset 6-9 years
more severe in females

Radiology:
delayed bone age
necrosis of capital femoral epiphysis

Skel:
legg-calve-perthes disease

Clinical features from OMIM:

150600

MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 APOH CD40LG COL2A1 F5 GALNS IGFBP3
2 growth/size/body region MP:0005378 10.14 COL2A1 F5 IGFBP3 MTHFR PEPD SELE
3 cardiovascular system MP:0005385 10.09 CD40LG COL2A1 F5 PEPD SELE SELP
4 integument MP:0010771 10.02 CD40LG F5 IGFBP3 MTHFR PEPD SELE
5 mortality/aging MP:0010768 10 APOH CD40LG COL2A1 F5 MTHFR PEPD
6 liver/biliary system MP:0005370 9.91 COL2A1 F5 IGFBP3 MTHFR SELE SELP
7 renal/urinary system MP:0005367 9.61 CD40LG COL2A1 GALNS PEPD SELP SERPINC1
8 skeleton MP:0005390 9.28 CD40LG COL2A1 GALNS IGFBP3 MTHFR PEPD

Drugs & Therapeutics for Legg-Calve-Perthes Disease

Drugs for Legg-Calve-Perthes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational 1406-66-2, 54-28-4 14986
2
Triamcinolone Approved, Vet_approved 124-94-7 31307
3
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
4 Tocotrienol Investigational 6829-55-6
5 Vitamins
6 Tocopherols
7 Tocotrienols
8 Anti-Inflammatory Agents
9 Triamcinolone diacetate
10 Triamcinolone hexacetonide
11 triamcinolone acetonide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-centre, Randomised, Parallel Group, Controlled Study to Compare the Performance of the Future Hip Against Three Currently Used Implants in Total Hip Replacement Terminated NCT00208468 Phase 3
2 The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' Disease Completed NCT02676271
3 The Effect of Perthes' Disease on Hip Cartilage Completed NCT00958464
4 Lateral Shelf Acetabuloplasty for Treatment of Older Children With Perthes Disease Recruiting NCT03321422
5 Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease Recruiting NCT02040714
6 Validation and Reliability Testing of the Western Ontario and McMaster Osteoarthritis Scale (WOMAC) Hip Score in Children and Adolescents With Perthes Disease Recruiting NCT02795494
7 A Prospective Multi-center Study on E1 Acetabular Liner in THA Active, not recruiting NCT02087449
8 Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral Density Active, not recruiting NCT02087436
9 A Prospective Nationwide Study of Perthes` Disease in Norway: Functional and Radiographic Outcomes at a Mean Follow-up of Twenty Years Enrolling by invitation NCT03885960
10 Intraarticular Corticosteroid Therapy in Legg-Calve Perthes Disease: a Randomized Controlled Clinical Trial. Terminated NCT01026909 Aristospan 20mg

Search NIH Clinical Center for Legg-Calve-Perthes Disease

Cochrane evidence based reviews: legg-calve-perthes disease

Genetic Tests for Legg-Calve-Perthes Disease

Genetic tests related to Legg-Calve-Perthes Disease:

# Genetic test Affiliating Genes
1 Coxa Plana 29 COL2A1

Anatomical Context for Legg-Calve-Perthes Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Legg-Calve-Perthes Disease:

19
Hip Joint

MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

40
Bone, Testes, Heart, Skeletal Muscle, Thyroid, Endothelial, Bone Marrow

Publications for Legg-Calve-Perthes Disease

Articles related to Legg-Calve-Perthes Disease:

(show top 50) (show all 2077)
# Title Authors PMID Year
1
A recurrent mutation in type II collagen gene causes Legg-Calvé-Perthes disease in a Japanese family. 61 56 6
17394019 2007
2
Protein C and S deficiency, thrombophilia, and hypofibrinolysis: pathophysiologic causes of Legg-Perthes disease. 61 56
8047373 1994
3
The role of venous hypertension in the pathogenesis of Legg-Perthes disease. A clinical and experimental study. 61 56
1993714 1991
4
Genetic risks in Perthes' disease. 61 56
963906 1976
5
Incidence and genetics of Legg-Perthes disease (osteochondritis deformans) in British Columbia: evidence of polygenic determination. 61 56
5046630 1972
6
Hereditary Legg-Calve-Perthes disease. 61 56
13998760 1963
7
Hereditary Legg-Calve-Perthes' disease. 61 56
20988421 1946
8
Legg-Calve-Perthes disease in two generations of male family members: a case report. 61 52
24014797 2013
9
Type II collagen gene variants and inherited osteonecrosis of the femoral head. 6
15930420 2005
10
Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13. 56
15179599 2004
11
Non-traumatic avascular necrosis of the femoral head. 56
7890797 1995
12
The early roentgenographic changes in essential coxa plana: their significance in pathogenesis. 56
5659978 1968
13
Legg-Calve-Perthes syndrome (LCPS). An up-to-date critical review. 56
13899540 1962
14
Perthes' disease and the search for genetic associations: collagen mutations, Gaucher's disease and thrombophilia. 54 61
18978274 2008
15
Legg-Calve-Perthes disease, venous and arterial thrombi, and the factor V Leiden mutation in a four-generation kindred. 54 61
17878795 2007
16
Legg-perthes disease and heritable thrombophilia. 54 61
15958894 2005
17
Legg-Calve-Perthes disease and thrombophilia. 54 61
15590848 2004
18
The most severe forms of Perthes' disease associated with the homozygous Factor V Leiden mutation. 54 61
15125132 2004
19
[Congenital disorders of hemostasis in children with Perthes disease]. 54 61
15587376 2004
20
Thrombotic and fibrinolytic alterations in the aseptic necrosis of femoral head. 54 61
12695746 2003
21
Prospective reevaluation of the association between thrombotic diathesis and legg-perthes disease. 54 61
12208918 2002
22
The role of protein C, protein S, and resistance to activated protein C in Legg-Perthes disease. 54 61
11389252 2001
23
[Incidence of thrombophilic factor V Leiden and prothrombin G20210A mutation in Perthes disease--a pilot study]. 54 61
11386104 2001
24
Incidence of thrombophilia in patients with Gaucher disease. 54 61
11146461 2000
25
The role of coagulation abnormalities in the development of Perthes' disease. 54 61
10963178 2000
26
Absence of congenital prethrombotic disorders in children with Legg-Perthes disease. 54 61
10647105 2000
27
Factor V Leiden and other hypercoagulable state mutations are not associated with osteonecrosis during or after treatment for pediatric malignancy. 54 61
10064667 1999
28
The role of inherited thrombotic disorders in the etiology of Legg-Calvé-Perthes disease. 54 61
9890293 1999
29
Legg-Perthes disease in three siblings, two heterozygous and one homozygous for the factor V Leiden mutation. 54 61
9602208 1998
30
Decreased levels of IGF binding protein-3 in serum from children with Perthes' disease. 54 61
9602767 1998
31
Resistance to activated protein C and Legg-Perthes disease. 54 61
9170375 1997
32
Skeletal immaturity, IGF-I and IGFBP-3 serum concentrations in Legg-Calvé-Perthes disease (skeletal immaturity, IGF-I and IGFBP-3 in LCPD). 54 61
8962421 1996
33
Normal plasma levels of IGF binding protein in Perthes' disease. Follow-up of previous report. 54 61
7694440 1993
34
Open Reduction and Internal Fixation for the Treatment of Symptomatic Osteochondritis Dissecans of the Femoral Head in Patients With Sequelae of Legg-Calvé-Perthes Disease. 61
32028473 2020
35
Pediatric Hip and Pelvis. 61
31779829 2020
36
Isolated Trochanteric Descent and Greater Trochanteric Apophyseodesis Are Not Effective in the Treatment of Post-Perthes Deformity. 61
31725028 2020
37
Direct Lateral Approach for Triple Pelvic Osteotomy. 61
31157758 2020
38
Legg-Calve-Perthes Disease: Correlation between Computed Radiography and Magnetic Resonance Imaging. 61
31915336 2020
39
Comparison of surgical and nonsurgical containment methods for patients with Legg-Calvé-Perthes disease of the onset ages between 6.0 and 8.0 years: Salter osteotomy versus a non-weight-bearing hip flexion-abduction brace. 61
31856043 2019
40
Outcome after osteochondroplasty and relative neck lengthening for patients with healed Legg-Calvé-Perthes disease: a retrospective cohort study of patients with hip-deformities treated with osteochondroplasty and relative neck lengthening. 61
31875728 2019
41
Research priorities in children requiring elective surgery for conditions affecting the lower limbs: a James Lind Alliance Priority Setting Partnership. 61
31892663 2019
42
Total Hip Arthroplasty for Secondary Causes of Arthritis An Increase in Time and Money. 61
31785135 2019
43
Arthrodiastasis in the management of Perthes disease: a systematic review. 61
31856037 2019
44
Developmental Dysplasia of the Hip with Concurrent Legg-Calvé-Perthes Disease in the Contralateral Hip. 61
32025416 2019
45
[Corrigendum] The role and underlying mechanisms of microRNA‑214 in Legg‑Calvé‑Perthes disease. 61
31485629 2019
46
Secondary hip dysplasia increases risk for early coxarthritis after Legg-Calve-Perthes disease. A study of 255 hips. 61
31429314 2019
47
Association of IL-6 -174G > C and -572G > C Polymorphisms with Risk of Legg-Calve-Perthes Disease in Iranian Children. 61
31757175 2019
48
Compensatory sagittal plane ankle gait mechanics: Are they present in patients with a weak or stiff hip? 61
31590046 2019
49
[The limping child: a red flag for every physician]. 61
31682088 2019
50
Anterolateral Approach in the Treatment of Femoroacetabular Impingement of the Hip. 61
31475056 2019

Variations for Legg-Calve-Perthes Disease

ClinVar genetic disease variations for Legg-Calve-Perthes Disease:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL2A1 NM_001844.5(COL2A1):c.258C>A (p.Cys86Ter)SNV Pathogenic 195148 rs794727261 12:48393736-48393736 12:47999953-47999953
2 COL2A1 NM_001844.5(COL2A1):c.2965C>T (p.Arg989Cys)SNV Pathogenic 17366 rs121912874 12:48372112-48372112 12:47978329-47978329
3 COL2A1 NM_001844.5(COL2A1):c.3508G>A (p.Gly1170Ser)SNV Pathogenic 17393 rs121912891 12:48369835-48369835 12:47976052-47976052
4 COL2A1 NM_001844.5(COL2A1):c.1957C>T (p.Arg653Ter)SNV Pathogenic 17395 rs121912893 12:48377504-48377504 12:47983721-47983721
5 46;XY;t(8;9)(q13;p22)dnTranslocation Pathogenic 267809
6 GNPTAB NM_024312.5(GNPTAB):c.1514G>A (p.Cys505Tyr)SNV Likely pathogenic 39035 rs281864980 12:102159967-102159967 12:101766189-101766189
7 COL2A1 NM_001844.5(COL2A1):c.803C>T (p.Pro268Leu)SNV Conflicting interpretations of pathogenicity 308931 rs142770543 12:48388220-48388220 12:47994437-47994437
8 COL2A1 NM_001844.5(COL2A1):c.2618G>T (p.Gly873Val)SNV Uncertain significance 547841 rs886042009 12:48374344-48374344 12:47980561-47980561

UniProtKB/Swiss-Prot genetic disease variations for Legg-Calve-Perthes Disease:

73
# Symbol AA change Variation ID SNP ID
1 COL2A1 p.Gly1170Ser VAR_023933 rs121912891

Expression for Legg-Calve-Perthes Disease

Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for Legg-Calve-Perthes Disease

Pathways related to Legg-Calve-Perthes Disease according to KEGG:

36
# Name Kegg Source Accession
1 Focal adhesion hsa04510
2 ECM-receptor interaction hsa04512

GO Terms for Legg-Calve-Perthes Disease

Cellular components related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 SERPINE1 SERPINC1 IGFBP3 GALNS F5 COL2A1
2 collagen-containing extracellular matrix GO:0062023 9.56 SERPINE1 SERPINC1 COL2A1 APOH
3 extracellular space GO:0005615 9.32 THBD SERPINE1 SERPINC1 SELP SELE IGFBP3
4 endoplasmic reticulum lumen GO:0005788 9.26 SERPINC1 IGFBP3 F5 COL2A1

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.56 SERPINE1 SELP F5 APOH
2 hemostasis GO:0007599 9.5 THBD SERPINC1 F5
3 leukocyte tethering or rolling GO:0050901 9.46 SELP SELE
4 positive regulation of blood coagulation GO:0030194 9.43 SERPINE1 APOH
5 negative regulation of smooth muscle cell migration GO:0014912 9.4 SERPINE1 IGFBP3
6 regulation of blood coagulation GO:0030193 9.37 SERPINC1 APOH
7 leukocyte cell-cell adhesion GO:0007159 9.33 SELP SELE CD40LG
8 negative regulation of blood coagulation GO:0030195 9.13 THBD SERPINE1 APOH
9 negative regulation of fibrinolysis GO:0051918 8.8 THBD SERPINE1 APOH

Molecular functions related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sialic acid binding GO:0033691 8.96 SELP SELE
2 oligosaccharide binding GO:0070492 8.62 SELP SELE

Sources for Legg-Calve-Perthes Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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