LCPD
MCID: LGG001
MIFTS: 61

Legg-Calve-Perthes Disease (LCPD)

Categories: Blood diseases, Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Legg-Calve-Perthes Disease

MalaCards integrated aliases for Legg-Calve-Perthes Disease:

Name: Legg-Calve-Perthes Disease 57 12 53 75 37 13 44 15 40 73
Perthes Disease 57 12 53 25 59 75 55
Coxa Plana 12 53 25 29 6
Lcpd 57 53 25 75
Legg-Calvé-Perthes Disease 25 59
Legg-Perthes Disease 57 75
Avascular Necrosis of the Capital Femoral Epiphysis 73
Aseptic Necrosis of the Capital Femoral Epiphysis 59
Osteochondritis of the Capital Femoral Epiphysis 59
Osteochondrosis of the Capital Femoral Epiphysis 59
Juvenile Osteochondrosis of Hip and/or Pelvis 12
Juvenile Osteochondrosis of Hip and Pelvis 12
Osteochondrosis of Legg-Calve-Perthes 12
Juvenile Osteochond-Hip/pelvis 12
Legg-Calve-Perthes Syndrome 53
Legg-Calve-Perthes Symptom 12
Leggcalv�perthes Syndrome 76
Osteochondritis Deformans 53
Calve - Perthes' Disease 12
Calve-Perthes Disease 25
Perthe's Disease 12
Pseudocoxalgia 12
Lcp 57

Characteristics:

Orphanet epidemiological data:

59
legg-calvé-perthes disease
Inheritance: Autosomal dominant,Multigenic/multifactorial; Age of onset: Childhood; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
autosomal dominant vs. multifactorial


Classifications:



External Ids:

OMIM 57 150600
Disease Ontology 12 DOID:14415
ICD10 33 M91.2 M91.3 M91
MeSH 44 D007873
NCIt 50 C34766
SNOMED-CT 68 15739006
Orphanet 59 ORPHA2380
UMLS via Orphanet 74 C0023234
ICD10 via Orphanet 34 M91.1
MedGen 42 C0023234
KEGG 37 H01526

Summaries for Legg-Calve-Perthes Disease

NIH Rare Diseases : 53 Legg-Calve-Perthes disease (LCPD) occurs when blood supply to the ball of the thighbone in the hip (femoral head) is disrupted. Without an adequate blood supply, the bone cells die. LCPD usually occurs in children between the ages of 4 and 10. Early symptoms may include limping; pain in the hip, thigh or knee; and reduced range of hip motion. Later in the disease course, there may be leg length discrepancy (one leg longer than the other) and wasting of the muscles around the hip. The condition can last for several years before new bone formation (re-ossification) and eventual healing occurs. Some people with LCPD go on to develop degenerative arthritis in adulthood. The underlying cause of LCPD is often not known. Sometimes it results from a slipped capital femoral epiphysis, trauma, steroid use, sickle-cell crisis, toxic synovitis, or congenital hip dysplasia. It usually is not caused by genetic factors, but a few familial cases with autosomal dominant inheritance have been reported. In a small percentage of cases, mutations in the COL2A1 gene were found to be responsible. Treatment aims to keep the thigh bone inside the hip socket. Treatment options may include rest or medication for pain; physical therapy; using a brace; or surgery.

MalaCards based summary : Legg-Calve-Perthes Disease, also known as perthes disease, is related to osteonecrosis and thrombophilia. An important gene associated with Legg-Calve-Perthes Disease is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Focal adhesion and ECM-receptor interaction. The drugs Triamcinolone and Tocopherol have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skeletal muscle, and related phenotypes are joint dislocation and delayed skeletal maturation

Disease Ontology : 12 An osteochondrosis that results in death and fracture located in hip joint.

Genetics Home Reference : 25 Legg-Calvé-Perthes disease is a bone disorder that affects the hips. Usually, only one hip is involved, but in about 10 percent of cases, both hips are affected. Legg-Calvé-Perthes disease begins in childhood, typically between ages 4 and 8, and affects boys more frequently than girls.

OMIM : 57 Legg-Calve-Perthes disease is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone. The disease occurs more frequently in boys, and most patients tend to be shorter than their peers. Both familial and isolated cases of LCPD have been reported (summary by Chen et al., 2004). (150600)

UniProtKB/Swiss-Prot : 75 Legg-Calve-Perthes disease: Characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Wikipedia : 76 Legg�??Calv�?Perthes disease (LCPD, also known as Perthes disease or Legg�??Perthes disease) is a... more...

Related Diseases for Legg-Calve-Perthes Disease

Diseases related to Legg-Calve-Perthes Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 osteonecrosis 30.6 SERPINE1 SERPINC1 COL2A1
2 thrombophilia 30.1 THBD SERPINE1 SERPINC1 F5 APOH
3 protein c deficiency 30.0 THBD SERPINC1 F5
4 brittle bone disorder 29.8 PEPD COL2A1
5 purpura 29.6 THBD SERPINC1 APOH
6 thrombosis 28.8 THBD SERPINE1 SERPINC1 SELP F5 APOH
7 arthrogryposis, perthes disease, and upward gaze palsy 12.6
8 lmna-related cardiocutaneous progeria syndrome 11.4
9 garret tripp syndrome 11.1
10 endosteal hyperostosis, autosomal dominant 11.0
11 osteomesopyknosis 11.0
12 upington disease 10.7
13 osteochondritis dissecans 10.6
14 multiple epiphyseal dysplasia 10.3
15 idiopathic avascular necrosis 10.3
16 arthritis 10.3
17 osteochondrosis 10.3
18 exostosis 10.3
19 synovitis 10.3
20 hypopituitarism 10.3
21 factor v leiden thrombophilia 10.3
22 kienbock's disease 10.3
23 synovial chondromatosis 10.3
24 slipped capital femoral epiphysis 10.3
25 neuroblastoma 10.2
26 genitourinary tract anomalies 10.2
27 scheie syndrome 10.2
28 gaucher's disease 10.2
29 fibrinolytic defect 10.2 SERPINC1 SERPINE1
30 marantic endocarditis 10.2 THBD SERPINC1
31 argentine hemorrhagic fever 10.2 SERPINE1 SERPINC1
32 aspirin allergy 10.2 SERPINE1 SERPINC1
33 blue toe syndrome 10.2 SERPINE1 SERPINC1
34 subendocardial myocardial infarction 10.2 SERPINE1 SERPINC1
35 osteoarthritis 10.1
36 sagittal sinus thrombosis 10.1 SERPINC1 F5
37 platelet aggregation, spontaneous 10.1 SERPINC1 SELP
38 factor xi deficiency 10.1 THBD SERPINC1
39 coronary thrombosis 10.1 SERPINE1 SERPINC1
40 hepatic vascular disease 10.1 SERPINE1 SERPINC1
41 mitral valve stenosis 10.1 SERPINC1 SELP
42 blood protein disease 10.1 SERPINC1 F5
43 intermediate coronary syndrome 10.1 SERPINC1 SELP
44 inferior vena cava interruption 10.1 F5 SERPINE1
45 amaurosis fugax 10.1 F5 SERPINE1
46 pulmonary artery disease 10.1 SERPINC1 F5
47 epileptic encephalopathy, childhood-onset 10.1 SERPINE1 SERPINC1
48 sneddon syndrome 10.1 SERPINC1 APOH
49 cryptogenic cirrhosis 10.1 SERPINE1 F5
50 carotid artery thrombosis 10.1 SERPINE1 SELP

Graphical network of the top 20 diseases related to Legg-Calve-Perthes Disease:



Diseases related to Legg-Calve-Perthes Disease

Symptoms & Phenotypes for Legg-Calve-Perthes Disease

Symptoms via clinical synopsis from OMIM:

57
Growth:
short stature

Limbs:
painful limp

Misc:
onset 6-9 years
more severe in females

Radiology:
delayed bone age
necrosis of capital femoral epiphysis

Skel:
legg-calve-perthes disease


Clinical features from OMIM:

150600

Human phenotypes related to Legg-Calve-Perthes Disease:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint dislocation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001373
2 delayed skeletal maturation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002750
3 aseptic necrosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0010885
4 abnormality of the dentition 59 32 hallmark (90%) Very frequent (99-80%) HP:0000164
5 short stature 59 32 hallmark (90%) Very frequent (99-80%) HP:0004322
6 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
7 skeletal muscle atrophy 59 32 hallmark (90%) Very frequent (99-80%) HP:0003202
8 cartilage destruction 59 32 hallmark (90%) Very frequent (99-80%) HP:0100773
9 avascular necrosis of the capital femoral epiphysis 32 HP:0005743

GenomeRNAi Phenotypes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 SELP SERPINC1 SERPINE1 THBD

MGI Mouse Phenotypes related to Legg-Calve-Perthes Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 CD40LG COL2A1 F5 PEPD SELP SERPINC1
2 homeostasis/metabolism MP:0005376 10.06 APOH CD40LG COL2A1 F5 PEPD SELP
3 immune system MP:0005387 9.91 CD40LG COL2A1 PEPD SELP SERPINC1 SERPINE1
4 embryo MP:0005380 9.83 COL2A1 F5 PEPD SERPINC1 THBD
5 mortality/aging MP:0010768 9.81 APOH CD40LG COL2A1 F5 PEPD SELP
6 integument MP:0010771 9.8 CD40LG F5 PEPD SELP SERPINE1 THBD
7 liver/biliary system MP:0005370 9.73 COL2A1 F5 SELP SERPINC1 SERPINE1 THBD
8 nervous system MP:0003631 9.5 CD40LG COL2A1 F5 PEPD SELP SERPINC1
9 renal/urinary system MP:0005367 9.17 CD40LG COL2A1 PEPD SELP SERPINC1 SERPINE1

Drugs & Therapeutics for Legg-Calve-Perthes Disease

Drugs for Legg-Calve-Perthes Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
2
Tocopherol Approved, Investigational 1406-66-2 14986
3
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
4 Tocotrienol Investigational 6829-55-6
5 Triamcinolone diacetate Not Applicable
6 Triamcinolone hexacetonide Not Applicable
7 Anti-Inflammatory Agents Not Applicable
8 triamcinolone acetonide Not Applicable
9 Immunologic Factors Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
11 Hormone Antagonists Not Applicable
12 Hormones Not Applicable
13 glucocorticoids Not Applicable
14 Immunosuppressive Agents Not Applicable
15 Tocopherols
16 Tocotrienols
17 Vitamins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement Terminated NCT00208468 Phase 3
2 Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease Recruiting NCT02040714
3 The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' Disease Completed NCT02676271
4 Intraarticular Corticosteroid Therapy in Perthes Disease. Terminated NCT01026909 Not Applicable Aristospan 20mg
5 WOMAC Hip Score in Children and Adolescents With Perthes Disease Recruiting NCT02795494
6 The Effect of Perthes' Disease on Hip Cartilage Recruiting NCT00958464
7 Lateral Shelf Acetabuloplasty in Perthes Disease Recruiting NCT03321422
8 Diagnosis of Mucopolysaccharidosis Disorders in Patients Presenting With Bilateral Hip Disease Completed NCT01707433
9 Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient Population Active, not recruiting NCT02087449
10 Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral Density Active, not recruiting NCT02087436 Not Applicable

Search NIH Clinical Center for Legg-Calve-Perthes Disease

Cochrane evidence based reviews: legg-calve-perthes disease

Genetic Tests for Legg-Calve-Perthes Disease

Genetic tests related to Legg-Calve-Perthes Disease:

# Genetic test Affiliating Genes
1 Coxa Plana 29 COL2A1

Anatomical Context for Legg-Calve-Perthes Disease

MalaCards organs/tissues related to Legg-Calve-Perthes Disease:

41
Bone, Testes, Skeletal Muscle, Myeloid, Spinal Cord, Placenta, Endothelial

The Foundational Model of Anatomy Ontology organs/tissues related to Legg-Calve-Perthes Disease:

19
Hip Joint

Publications for Legg-Calve-Perthes Disease

Articles related to Legg-Calve-Perthes Disease:

(show top 50) (show all 604)
# Title Authors Year
1
Quantitative MRI Helps to Detect Hip Ischemia: Preclinical Model of Legg-Calvé-Perthes Disease. ( 30063188 )
2018
2
Outcomes in patients with late sequelae (healed stage) of Legg-Calvé-Perthes disease undergoing arthroscopic treatment: retrospective case series. ( 29192726 )
2018
3
Is Legg-Calvé-Perthes Disease a Local Manifestation of a Systemic Condition? ( 29481348 )
2018
4
Effectiveness of Strontium Ranelate in the Treatment of Rat Model of Legg-Calve-Perthes Disease. ( 30078896 )
2018
5
Imageless Navigation Improves Intraoperative Monitoring of Leg Length Changes during Total Hip Arthroplasty for Legg-Calve-Perthes Disease: Two Case Reports. ( 30123597 )
2018
6
Pediatric Hip Disorders: Slipped Capital Femoral Epiphysis and Legg-Calvé-Perthes Disease. ( 30171056 )
2018
7
What are the Demographics and Epidemiology of Legg-Calvé-Perthes Disease in a Large Southern California Integrated Health System? ( 30211706 )
2018
8
Association of MTHFR and TNF-α genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study. ( 30224855 )
2018
9
A Case of Animal and Domestic Abuse Initially Diagnosed as Legg-Calve-Perthes Disease. ( 30272484 )
2018
10
MRI and sonography in Legg-Calvé-Perthes disease: clinical relevance of containment and influence on treatment. ( 30294371 )
2018
11
Agreement of radiographic measurements and patient-reported outcome in 61 patients with Legg-Calvé-Perthes disease at mean follow-up of 28 years. ( 30308553 )
2018
12
CORR Insights®: What are the Demographics and Epidemiology of Legg-Calvé-Perthes Disease in a Large Southern California Integrated Health System? ( 30422968 )
2018
13
Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg-calvé-perthes disease. ( 30556613 )
2018
14
Is VEGF under-expressed in Indian children with Perthes disease? ( 28956304 )
2018
15
New insights into the biomechanics of Legg-Calvé-Perthes' disease: The Role of Epiphyseal Skeletal Immaturity in Vascular Obstruction. ( 29437587 )
2018
16
Short Term Outcome of Varus Derotation Osteotomy in Late Presenting Perthes Disease. ( 29576640 )
2018
17
Treatment outcome of dome osteotomy of the pelvis combined with trochanteric advancement for sequelae of Perthes' disease. ( 29598843 )
2018
18
A simple, precocious, and reliable way to assess future clinical outcome in children with Perthes disease and mild femoral head involvement: correlation between MRI with diffusion-weighted and dynamic gadolinium-enhanced subtraction and Catterall and Herring classifications. ( 29696413 )
2018
19
The outcomes of Perthes' disease of the hip: a study protocol for the development of a core outcome set. ( 30005667 )
2018
20
Height-Width Ratio of Proximal Femoral Epiphysis: Estimation of Lateral Pillar Involvement in Bilateral Perthes Disease. ( 30199461 )
2018
21
Outcome of Closed Wedge Varus Derotation Osteotomy with Trochanteric Apophysiodesis in Perthes Disease. ( 30532302 )
2018
22
Synovial osteochondromatosis in a 14-year-old boy with a history of Legg-Calve-Perthes disease. ( 28491198 )
2017
23
The Declining Incidence of Legg-Calve-Perthes' Disease in Northern Ireland: An Epidemiological Study. ( 27328117 )
2017
24
Monobloc implants in cementless total hip arthroplasty in patients with Legg-Calve-Perthes disease: a long-term follow-up. ( 28870190 )
2017
25
Correlation between MRI and hip arthroscopy in children with Legg-Calve-Perthes disease. ( 29027115 )
2017
26
A probable case of Legg-Calvé-Perthes disease in Warring States-era China. ( 28290307 )
2017
27
Determining Hinge Abduction in Legg-Calvé-Perthes Disease: Can We Reliably Make the Diagnosis? ( 29219855 )
2017
28
Incidence of Perthes' disease in children born between 1973 and 1993. ( 27587239 )
2017
29
Denosumab and surgery for the treatment of Perthes' disease in a 9-year-old boy: favorable course documented by comprehensive imaging- a case report. ( 28290756 )
2017
30
Total hip arthroplasty using a monobloc cementless femoral stem for patients with childhood Perthes' disease. ( 28385931 )
2017
31
Radiographic classifications in Perthes disease. ( 28613966 )
2017
32
A long-term follow-up study of the clinical and radiographic outcome of distal trochanteric transfer in Legg-Calvé-Perthes' disease following varus derotational osteotomy. ( 28663408 )
2017
33
A case control study to determine the association between Perthes' disease and the recalled use of tobacco during pregnancy, and biological markers of current tobacco smoke exposure. ( 28768789 )
2017
34
A method to investigate the biomechanical alterations in Perthes' disease by hip joint contact modeling. ( 28869431 )
2017
35
Protocol for a randomised control trial of bisphosphonate (zoledronic acid) treatment in childhood femoral head avascular necrosis due to Perthes disease. ( 29637122 )
2017
36
Treatment of Late-Onset Legg-Calve-Perthes Disease by Arthrodiastasis. ( 27904729 )
2016
37
Alumina-alumina total hip arthroplasty for the sequelae of Legg-Calve-Perthes disease: A comparative study with adult-onset osteonecrosis. ( 27522609 )
2016
38
Bilateral Legg-Calve-Perthes Disease and Kienbock's Disease in a Child With Factor V Leiden Thrombophilia: A Case Report. ( 27698645 )
2016
39
Legg-Calve-Perthes disease: A must know entity for anaesthesiologists. ( 26962263 )
2016
40
A Case of Legg-Calvé-Perthes Disease due to Transient Synovitis of the Hip. ( 27478667 )
2016
41
Skeletal immaturity, rostral sparing, and disparate hip morphologies as biomechanical causes for Legg-Calvé-Perthes' disease. ( 26780125 )
2016
42
A Twin Study of Perthes Disease. ( 26908702 )
2016
43
The outcome and prognostic factors in children with bilateral Perthes' disease: a prospective study of 40 children with follow-up over five years. ( 27037442 )
2016
44
The lognormal age of onset distribution in Perthes' disease: an analysis from a large well-defined cohort. ( 27143746 )
2016
45
Acetabular anteversion angle from early stage of Perthes disease to adolescence. ( 27621557 )
2016
46
Treatment of Arthritis Associated With Legg-Calve-Perthes Disease With Modular Total Hip Arthroplasty. ( 25979188 )
2015
47
TAPnnis triple pelvic osteotomy for Legg-Calve-Perthes disease. ( 25417791 )
2015
48
Triple osteotomy of the pelvis for Legg-Calve-Perthes disease: a mean fifteen year follow-up. ( 25645439 )
2015
49
Hypopituitarism and Legg-Calve-Perthes disease related to difficult delivery. ( 26300943 )
2015
50
Advanced Containment With Triple Innominate Osteotomy in Legg-Calve-Perthes Disease: A Viable Option Even in Severe Cases. ( 26683505 )
2015

Variations for Legg-Calve-Perthes Disease

UniProtKB/Swiss-Prot genetic disease variations for Legg-Calve-Perthes Disease:

75
# Symbol AA change Variation ID SNP ID
1 COL2A1 p.Gly1170Ser VAR_023933 rs121912891

ClinVar genetic disease variations for Legg-Calve-Perthes Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL2A1 NM_001844.4(COL2A1): c.3508G> A (p.Gly1170Ser) single nucleotide variant Pathogenic rs121912891 GRCh37 Chromosome 12, 48369835: 48369835
2 COL2A1 NM_001844.4(COL2A1): c.3508G> A (p.Gly1170Ser) single nucleotide variant Pathogenic rs121912891 GRCh38 Chromosome 12, 47976052: 47976052
3 GNPTAB NM_024312.4(GNPTAB): c.1514G> A (p.Cys505Tyr) single nucleotide variant Likely pathogenic rs281864980 GRCh37 Chromosome 12, 102159967: 102159967
4 GNPTAB NM_024312.4(GNPTAB): c.1514G> A (p.Cys505Tyr) single nucleotide variant Likely pathogenic rs281864980 GRCh38 Chromosome 12, 101766189: 101766189
5 COL2A1 NM_001844.4(COL2A1): c.2618G> T (p.Gly873Val) single nucleotide variant Uncertain significance rs886042009 GRCh37 Chromosome 12, 48374344: 48374344
6 COL2A1 NM_001844.4(COL2A1): c.2618G> T (p.Gly873Val) single nucleotide variant Uncertain significance rs886042009 GRCh38 Chromosome 12, 47980561: 47980561

Expression for Legg-Calve-Perthes Disease

Search GEO for disease gene expression data for Legg-Calve-Perthes Disease.

Pathways for Legg-Calve-Perthes Disease

Pathways related to Legg-Calve-Perthes Disease according to KEGG:

37
# Name Kegg Source Accession
1 Focal adhesion hsa04510
2 ECM-receptor interaction hsa04512

GO Terms for Legg-Calve-Perthes Disease

Cellular components related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 APOH CD40LG COL2A1 F5 SERPINC1 SERPINE1
2 endoplasmic reticulum lumen GO:0005788 9.43 COL2A1 F5 SERPINC1
3 collagen-containing extracellular matrix GO:0062023 9.26 APOH COL2A1 SERPINC1 SERPINE1
4 extracellular space GO:0005615 9.23 APOH CD40LG COL2A1 F5 SELP SERPINC1

Biological processes related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.58 F5 SERPINC1 THBD
2 platelet degranulation GO:0002576 9.46 APOH F5 SELP SERPINE1
3 leukocyte cell-cell adhesion GO:0007159 9.43 CD40LG SELP
4 hemostasis GO:0007599 9.43 F5 SERPINC1 THBD
5 positive regulation of blood coagulation GO:0030194 9.37 APOH SERPINE1
6 regulation of blood coagulation GO:0030193 9.32 APOH SERPINC1
7 negative regulation of blood coagulation GO:0030195 9.13 APOH SERPINE1 THBD
8 negative regulation of fibrinolysis GO:0051918 8.8 APOH SERPINE1 THBD

Molecular functions related to Legg-Calve-Perthes Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH SELP SERPINC1

Sources for Legg-Calve-Perthes Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....