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MCID: LGN002
MIFTS: 65

Legionellosis

Categories: Rare diseases, Infectious diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Legionellosis

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MalaCards integrated aliases for Legionellosis:

Name: Legionellosis 12 76 53 59 29 6 3 44 15 40 73
Legionella Infection 12 53
Legionnaires Disease 59 55
Pontiac Fever 53 73
Legionaire Disease, Susceptibility to 13
Legionnaires' Disease 73
Legionnaire's Disease 53

Characteristics:

Orphanet epidemiological data:

59
legionellosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (France); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 34 33
Orphanet: 59  
Rare infectious diseases


Sources

Summaries for Legionellosis

About this section
CDC : 3 Legionnaires’ (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. Legionella can also cause a milder illness called Pontiac fever. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella. Most people exposed to Legionella do not get sick. However, people 50 years or older, current or former smokers, and people with a weakened immune system or chronic disease are at increased risk.

MalaCards based summary : Legionellosis, also known as legionella infection, is related to legionnaires' disease and brucellosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Legionellosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and testes, and related phenotypes are renal insufficiency and proteinuria

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

Wikipedia : 76 Legionnaires\' disease is a form of atypical pneumonia caused by any type of Legionella bacteria. Signs... more...

Sources

Related Diseases for Legionellosis

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Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 legionnaires' disease 30.2 CD40LG NLRC4 PIK3C2A TLR4 TLR5
2 brucellosis 28.5 CD40LG TLR4 TNF
3 pneumonia 27.3 CD40LG PIK3C2A TLR2 TLR4 TLR5 TNF
4 pontiac fever 11.3
5 prosthetic joint infection 10.5 TLR2 TLR4
6 retinitis pigmentosa 49 10.5 EEF1A2 HBS1L
7 tularemia 10.5 CASP1 TLR2
8 enterocolitis 10.5 NLRC4 TLR4
9 acute cervicitis 10.5 TLR2 TLR4
10 salmonellosis 10.4 CASP1 NLRC4 TLR4
11 granulomatous myositis 10.3 NAIP PIK3C2A
12 mesenteric lymphadenitis 10.3 MYD88 TLR2
13 macrophage activation syndrome 10.3 NLRC4 TNF
14 septic arthritis 10.3 TLR2 TLR4 TLR5
15 spondylarthropathy 10.2 TLR4 TNF
16 haemophilus influenzae 10.2 TLR2 TNF
17 nontuberculous mycobacterial lung disease 10.1 TLR2 TNF
18 ocular toxoplasmosis 10.1 CD40LG TLR5
19 legionnaire disease 10.1
20 mycobacterium abscessus 10.1 TLR2 TNF
21 heavy chain disease 10.1 CD40LG MYD88
22 monoclonal paraproteinemia 10.0 CD40LG MYD88
23 erysipelas 10.0 PIK3C2A TNF
24 lymphoplasmacytic lymphoma 9.9 CD40LG MYD88
25 coccidioidomycosis 9.9 CD40LG TLR4
26 irak4 deficiency 9.9 MYD88 TLR2 TLR4 TLR5
27 myd88 deficiency 9.9 MYD88 TLR2 TLR4 TLR5
28 plasma protein metabolism disease 9.9 CD40LG MYD88
29 gamma heavy chain disease 9.9 CD40LG MYD88
30 trichostrongyloidiasis 9.9 CD40LG PIK3C2A
31 penicilliosis 9.8 TLR2 TLR4 TNF
32 aspergillosis 9.8
33 invasive aspergillosis 9.8
34 lung abscess 9.8
35 pertussis 9.8
36 alveolar echinococcosis 9.8 TLR2 TLR4 TNF
37 paracoccidioidomycosis 9.8 TLR2 TLR4 TNF
38 bacterial vaginosis 9.8 TLR2 TLR4 TNF
39 ornithosis 9.8 CD40LG PIK3C2A
40 filariasis 9.8 TLR2 TLR4 TNF
41 toxic shock syndrome 9.8 TLR2 TLR4 TNF
42 chagas disease 9.8 TLR2 TLR4 TNF
43 periodontitis 9.8 TLR2 TLR4 TNF
44 visceral leishmaniasis 9.8 TLR2 TLR4 TNF
45 leishmaniasis 9.8 TLR2 TLR4 TNF
46 trichinosis 9.8 CD40LG PIK3C2A
47 periodontal disease 9.8 TLR2 TLR4 TNF
48 pyelitis 9.7 CD40LG TLR4
49 crimean-congo hemorrhagic fever 9.7 PIK3C2A TNF
50 encephalitozoonosis 9.7 CD40LG TNF

Graphical network of the top 20 diseases related to Legionellosis:



Diseases related to Legionellosis
Sources

Symptoms & Phenotypes for Legionellosis

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Human phenotypes related to Legionellosis:

59 32 (show all 42)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
2 proteinuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000093
3 hallucinations 59 32 occasional (7.5%) Occasional (29-5%) HP:0000738
4 hematuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000790
5 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
6 ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001251
7 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
8 pericarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001701
9 pancreatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001733
10 splenomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0001744
11 lymphopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001888
12 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
13 diarrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002014
14 nausea and vomiting 59 32 occasional (7.5%) Occasional (29-5%) HP:0002017
15 abdominal pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002027
16 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
17 migraine 59 32 occasional (7.5%) Occasional (29-5%) HP:0002076
18 restrictive ventilatory defect 59 32 occasional (7.5%) Occasional (29-5%) HP:0002091
19 respiratory insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002093
20 abnormality of the pleura 59 32 occasional (7.5%) Occasional (29-5%) HP:0002103
21 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
22 pulmonary infiltrates 59 32 hallmark (90%) Very frequent (99-80%) HP:0002113
23 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
24 hypotension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002615
25 lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002716
26 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
27 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
28 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
29 reduced consciousness/confusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0004372
30 bone marrow hypocellularity 59 32 occasional (7.5%) Occasional (29-5%) HP:0005528
31 peripheral neuropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0009830
32 arrhythmia 59 32 frequent (33%) Frequent (79-30%) HP:0011675
33 hepatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012115
34 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
35 cough 59 32 hallmark (90%) Very frequent (99-80%) HP:0012735
36 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
37 endocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100584
38 cellulitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100658
39 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
40 recurrent pharyngitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100776
41 sepsis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100806
42 abnormality of lung morphology 59 Very frequent (99-80%)

UMLS symptoms related to Legionellosis:


coughing, fever, pruritus, snoring

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CASP1 CD40LG MYD88 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CASP1 CD40LG MYD88 NAIP NLRC4 TNF

MGI Mouse Phenotypes related to Legionellosis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.18 TLR4 TLR5 TLR2 TNF CD40LG NLRC4
2 hematopoietic system MP:0005397 10.14 TLR4 TLR5 TNF NLRC4 PIK3C2A EEF1A2
3 cardiovascular system MP:0005385 10.1 TLR4 TLR5 TLR2 TNF CD40LG PIK3C2A
4 immune system MP:0005387 10.06 TLR4 TLR5 TLR2 TNF CD40LG NLRC4
5 adipose tissue MP:0005375 10.05 TLR4 TLR5 TLR2 TNF PIK3C2A HBS1L
6 homeostasis/metabolism MP:0005376 10.02 TNF TLR4 TLR5 TLR2 CD40LG PIK3C2A
7 endocrine/exocrine gland MP:0005379 9.98 TLR5 TLR2 TNF CD40LG EEF1A2 CASP1
8 mortality/aging MP:0010768 9.96 TLR4 TLR5 TLR2 TNF CD40LG PIK3C2A
9 digestive/alimentary MP:0005381 9.93 TLR4 TLR5 TLR2 TNF CASP1 MYD88
10 nervous system MP:0003631 9.56 TNF TLR4 TLR2 CD40LG PIK3C2A EEF1A2
11 neoplasm MP:0002006 9.55 TLR2 TNF TLR4 MYD88 CASP1
12 renal/urinary system MP:0005367 9.1 TLR4 TLR2 CD40LG PIK3C2A CASP1 MYD88
Sources

Drugs & Therapeutics for Legionellosis

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Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4 Anti-Bacterial Agents Phase 4,Phase 1
5 Antibiotics, Antitubercular Phase 4,Phase 1
6 Anti-Infective Agents Phase 4,Phase 1
7 Antitubercular Agents Phase 4,Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Erythromycin Estolate Phase 4
11 Erythromycin Ethylsuccinate Phase 4
12 Erythromycin stearate Phase 4
13
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
14 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
15
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
16
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
17
Kanamycin Approved, Investigational, Vet_approved Phase 1 8063-07-8, 59-01-8 6032
18
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
19
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
20
Polyestradiol phosphate Approved Phase 1 28014-46-2
21
Pyrazinamide Approved, Investigational Phase 1 98-96-4 1046
22
Rifampicin Approved Phase 1 13292-46-1 5458213 5381226
23
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
24
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
25
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
26 Antimetabolites Phase 1
27 Catalase Phase 1
28 Contraceptive Agents Phase 1
29 Contraceptives, Oral Phase 1
30 Contraceptives, Oral, Combined Phase 1
31 Cytochrome P-450 CYP3A Inducers Phase 1
32 Estradiol 17 beta-cypionate Phase 1
33 Estradiol 3-benzoate Phase 1
34 Fluoroquinolones Phase 1
35 Hypolipidemic Agents Phase 1
36 Lipid Regulating Agents Phase 1
37 Nicotinic Acids Phase 1
38 Norgestimate, ethinyl estradiol drug combination Phase 1
39 Nucleic Acid Synthesis Inhibitors Phase 1
40 Topoisomerase Inhibitors Phase 1
41 Vitamin B3 Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
3 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
4 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
5 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
6 Legionnaires' Effect on Smell Recruiting NCT03321786
7 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Not yet recruiting NCT03064737 Not Applicable
8 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
9 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153 Not Applicable

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: legionellosis

Sources

Genetic Tests for Legionellosis

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Genetic tests related to Legionellosis:

# Genetic test Affiliating Genes
1 Legionellosis 29 TLR5
Sources

Anatomical Context for Legionellosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

19
Respiratory Tract

MalaCards organs/tissues related to Legionellosis:

41
Lung, Testes, Bone Marrow, Bone, Colon, Heart, T Cells
Sources

Publications for Legionellosis

About this section

Articles related to Legionellosis:

(show top 50) (show all 328)
# Title Authors Year
1
Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211. ( 29247056 )
2018
2
Characterization of <i>Legionella pneumophila</i> and <i>Legionella</i> species from legionellosis patients in Japan between 2008 and 2016. ( 29980559 )
2018
3
Combining Environmental Investigation and a Dual-Analytical Strategy to Isolate the Legionella longbeachae Strain Linked to Two Occupational Cases of Legionellosis. ( 29304227 )
2018
4
Association Between Sporadic Legionellosis and River Systems in Connecticut. ( 29211873 )
2018
5
Control and prevention measures for legionellosis in hospitals: A cross-sectional survey in Italy. ( 29864633 )
2018
6
Of Time and the River: How Our Understanding of Legionellosis Has Changed Since 1976. ( 29211906 )
2018
7
Notes from the Field: Legionellosis Outbreak Associated with a Hotel Aquatics Facility - Tennessee, 2017. ( 29346335 )
2018
8
Legionellosis in the occupational setting. ( 27717486 )
2017
9
Legionnaires' Disease (Legionella Infection) ( 28613558 )
2017
10
Is Legionellosis Present and Important in Colombia? An Analyses of Cases from 2009 to 2013. ( 28465870 )
2017
11
Legionella longbeachae detected in an industrial cooling tower linked to a legionellosis outbreak, New Zealand, 2015; possible waterborne transmission? ( 28625225 )
2017
12
From 'Legionellosis acquired through a dental unit' to 'Was Legionellosis acquired through a dental unit?' ( 28457583 )
2017
13
Risk assessment of legionellosis in cardiology units. ( 28900358 )
2017
14
Male Neonate with Legionellosis. ( 29194478 )
2017
15
Legionellosis: a Walk-through to Identification of the Source of Infection. ( 29022684 )
2017
16
Legionellosis following water birth in a hot tub in a Canadian neonate. ( 29061856 )
2017
17
Analysis of population-level determinants of legionellosis: spatial and geovisual methods for enhancing classification of high-risk areas. ( 29197383 )
2017
18
Diagnosis of Extrapulmonary Legionellosis in Allogeneic Hematopoietic Cell Transplant Recipients by Direct 16S Ribosomal Ribonucleic Acid Sequencing and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. ( 28852679 )
2017
19
Legionella prevalence and risk of legionellosis in Japanese households. ( 28166862 )
2017
20
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
2017
21
Comparison of sputum microbiome of legionellosis-associated patients and other pneumonia patients: indications for polybacterial infections. ( 28059171 )
2017
22
Legionellosis in Poland in 2015 ( 29181967 )
2017
23
Legionellosis acquired through a dental unit: a case study. ( 28228245 )
2017
24
Under the Weather: Legionellosis and Meteorological Factors. ( 26993637 )
2016
25
Microbiological diagnosis and molecular typing of Legionella strains during an outbreak of legionellosis in Southern Germany. ( 26868659 )
2016
26
A single Legionella pneumophila genotype in the freshwater system in a ship experiencing three separate outbreaks of legionellosis in 6 years. ( 27515183 )
2016
27
Legionellosis in Poland in 2014 ( 27779835 )
2016
28
Legionellosis in Transplantation. ( 26857395 )
2016
29
Case of Legionella pneumophila pneumonia (legionellosis) developed in a psoriatic arthritis patient receiving adalimumab. ( 27651216 )
2016
30
Legionellosis protection requirements. How to comply with ASHRAE's standard for building water systems. ( 27323504 )
2016
31
Pulmonary Legionellosis in Oncologic Patients: Findings on Chest CT. ( 27454787 )
2016
32
Legionellosis in Poland in 2013. ( 26233078 )
2015
33
Active Bacterial Core Surveillance for Legionellosis - United States, 2011-2013. ( 26513329 )
2015
34
Utility of PCR, Culture, and Antigen Detection Methods for Diagnosis of Legionellosis. ( 26292304 )
2015
35
A Review of Guidelines for the Primary Prevention of Legionellosis inA Long-Term Care Facilities. ( 26155722 )
2015
36
Legionellosis Outbreak Associated With a Hotel Fountain. ( 26716104 )
2015
37
Post-Legionellosis Proliferative Glomerulonephritis. ( 26648502 )
2015
38
Legionella prevalence and risk of legionellosis in Hungarian hospitals. ( 26689882 )
2015
39
Problem of immunoglobulin M co-detection in serological response to bacterial and viral respiratory pathogens among children suspected of legionellosis. ( 26557031 )
2015
40
Genomic Investigation of a Legionellosis Outbreak in a Persistently Colonized Hotel. ( 26834713 )
2015
41
Legionellosis and psoriasis in biologic era. ( 25686289 )
2015
42
Reducing the risk for waterborne nosocomial neonatal legionellosis. ( 25988326 )
2015
43
Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer. ( 25926494 )
2015
44
Fatal legionellosis after water birth, Texas, USA, 2014. ( 25531804 )
2015
45
Reducing the risk of legionellosis in stem cell transplant recipients. ( 25581611 )
2015
46
Cross-reactions in IgM ELISA tests to Legionella pneumophila sg1 and Bordetella pertussis among children suspected of legionellosis; potential impact of vaccination against pertussis? ( 26557032 )
2015
47
Draft Genome Sequence of a Legionella pneumophila Serogroup 4 Strain Causing Legionellosis. ( 24948769 )
2014
48
Legionellosis in Poland in 2012. ( 25135503 )
2014
49
Community outbreak of legionellosis and an environmental investigation into a community water system. ( 25083716 )
2014
50
Molecular Characterization of Legionellosis Drug Target Candidate Enzyme Phosphoglucosamine Mutase from Legionella pneumophila (strain Paris): An In Silico Approach. ( 25705169 )
2014
Sources

Variations for Legionellosis

About this section

ClinVar genetic disease variations for Legionellosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh37 Chromosome 1, 223285200: 223285200
2 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh38 Chromosome 1, 223111858: 223111858
3 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh37 Chromosome 1, 223284599: 223284599
4 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh38 Chromosome 1, 223111257: 223111257
Sources

Expression for Legionellosis

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Search GEO for disease gene expression data for Legionellosis.
Sources

Pathways for Legionellosis

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Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.89 ARF1 CASP1 CD40LG MYD88 NLRC4 TLR2
2
Akt Signaling 64
Show member pathways
 13.27 CD40LG MYD88 TLR2 TLR4 TLR5 TNF
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.71 CASP1 MYD88 NAIP NLRC4 TLR2 TLR4
4
Apoptosis Modulation and Signaling 1
Show member pathways
 12.68 CASP1 MYD88 NAIP TNF
5
Influenza A 37
Show member pathways
 12.68 CASP1 MYD88 TLR2 TLR4 TNF
6
IL-2 Pathway 64
Show member pathways
 12.67 MYD88 PIK3C2A TLR2 TLR4 TLR5 TNF
7
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.63 CASP1 MYD88 TLR4 TNF
8
NF-KappaB Family Pathway 64
Show member pathways
 12.55 CD40LG MYD88 TLR2 TLR4 TLR5 TNF
9
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.46 MYD88 TLR2 TLR4 TNF
10
NF-kappaB Signaling 4
12.45 CD40LG MYD88 TLR2 TNF
11
Th17 cell differentiation 37
Show member pathways
 12.33 TLR2 TLR4 TLR5 TNF
12
VEGF Pathway (Qiagen) 64
Show member pathways
 12.3 MYD88 TLR2 TLR4 TLR5
13
Th1 Differentiation Pathway 65
Show member pathways
 12.16 TLR2 TLR4 TLR5 TNF
14
Toll Comparative Pathway 64
Show member pathways
 12.14 MYD88 TLR4 TNF
15
Tuberculosis 37
12.12 MYD88 TLR2 TLR4 TNF
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.11 MYD88 TLR2 TLR4 TLR5 TNF
17
IL-1 Family Signaling Pathways 65
Show member pathways
 12.1 MYD88 TLR2 TLR5 TNF
18
C-type lectin receptor signaling pathway 37
Show member pathways
 12.09 CASP1 MYD88 TNF
19
Necroptosis 37
Show member pathways
 12.09 CASP1 TLR4 TNF
20
Colorectal Cancer Metastasis 64
12.07 TLR2 TLR4 TLR5 TNF
21
Toxoplasmosis 37
Show member pathways
 12.07 CD40LG MYD88 TLR2 TLR4 TNF
22
TRAF Pathway 64
Show member pathways
 12.03 CASP1 CD40LG MYD88 TLR2 TLR4 TLR5
23
Bacterial infections in CF airways 22
Show member pathways
 11.98 MYD88 TLR2 TLR4 TLR5 TNF
24
MAPK Pathway 72
Show member pathways
 11.92 PIK3C2A TLR2 TLR4 TLR5
25
Amoebiasis 37
11.79 TLR2 TLR4 TNF
26
NF-kappa B signaling pathway 37
11.77 CD40LG MYD88 TLR4 TNF
27
Rheumatoid arthritis 37
11.75 TLR2 TLR4 TNF
28
Phagocytosis of Microbes 64
11.72 TLR2 TLR4 TLR5
29
Pertussis 37
11.66 CASP1 MYD88 TLR4 TNF
30
Salmonella infection (KEGG) 37
11.65 CASP1 MYD88 NLRC4 TLR4 TLR5
31
NF-kB (NFkB) Pathway 67
11.64 MYD88 TLR4 TNF
32
Transcription_NF-kB signaling pathway 22
11.5 MYD88 TLR4 TNF
33
MSP-RON Signaling 64
11.43 TLR2 TLR4 TNF
34
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
11.33 CASP1 NAIP NLRC4
35
Malaria 37
11.24 CD40LG MYD88 TLR2 TLR4 TNF
36
Legionellosis 37
11.1 ARF1 CASP1 EEF1A2 HBS1L MYD88 NAIP
37
IL1 and megakaryocytes in obesity 1
11.06 MYD88 TLR2
38
Cellular roles of Anthrax toxin 1
11 CASP1 TNF
39
NTHi-Induced Signaling 64
10.98 MYD88 TLR2
Sources

GO Terms for Legionellosis

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Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.5 ARF1 CD40LG HBS1L NLRC4 PIK3C2A TLR4
2 IPAF inflammasome complex GO:0072557 8.62 CASP1 NLRC4

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 MYD88 TLR2 TLR4 TNF
2 immune system process GO:0002376 9.99 MYD88 NAIP NLRC4 TLR2 TLR4 TLR5
3 innate immune response GO:0045087 9.97 MYD88 NAIP NLRC4 TLR2 TLR4 TLR5
4 defense response to bacterium GO:0042742 9.92 NLRC4 TLR4 TLR5 TNF
5 response to lipopolysaccharide GO:0032496 9.91 CASP1 MYD88 TLR2 TLR4
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.87 CASP1 MYD88 TLR4 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.85 MYD88 TLR2 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.85 CASP1 TLR4 TLR5 TNF
9 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.83 CASP1 NLRC4 TNF
10 positive regulation of JNK cascade GO:0046330 9.8 MYD88 TLR4 TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 TLR2 TLR4 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.76 MYD88 TLR2 TLR4
13 regulation of inflammatory response GO:0050727 9.76 CASP1 MYD88 TLR4 TNF
14 toll-like receptor signaling pathway GO:0002224 9.75 MYD88 TLR2 TLR4
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 TLR4 TLR5 TNF
16 cellular response to mechanical stimulus GO:0071260 9.73 CASP1 MYD88 TLR4 TLR5
17 positive regulation of interleukin-12 production GO:0032735 9.71 CD40LG TLR2 TLR4
18 positive regulation of cytokine secretion GO:0050715 9.7 CASP1 TNF
19 negative regulation of interleukin-6 production GO:0032715 9.7 TLR4 TNF
20 positive regulation of interleukin-10 production GO:0032733 9.7 CD40LG TLR2 TLR4
21 positive regulation of interleukin-1 beta secretion GO:0050718 9.69 CASP1 TLR4
22 positive regulation of interferon-beta production GO:0032728 9.69 TLR2 TLR4
23 activation of innate immune response GO:0002218 9.69 NLRC4 TLR4
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.68 MYD88 TLR4
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR4
26 negative regulation of growth of symbiont in host GO:0044130 9.68 MYD88 TNF
27 pyroptosis GO:0070269 9.67 CASP1 NLRC4
28 I-kappaB phosphorylation GO:0007252 9.67 TLR2 TLR4
29 positive regulation of interleukin-6 production GO:0032755 9.67 MYD88 TLR2 TLR4 TNF
30 inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:1990001 9.66 NAIP NLRC4
31 cellular response to lipoteichoic acid GO:0071223 9.65 TLR2 TLR4
32 positive regulation of lymphocyte proliferation GO:0050671 9.65 MYD88 TLR4
33 positive regulation of chemokine production GO:0032722 9.65 TLR2 TLR4 TNF
34 positive regulation of chemokine biosynthetic process GO:0045080 9.64 MYD88 TNF
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.64 TLR4 TNF
36 interleukin-1 beta secretion GO:0050702 9.63 NLRC4 TLR4
37 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.62 MYD88 TLR4
38 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 MYD88 TLR2 TLR4 TLR5
39 regulation of immunoglobulin secretion GO:0051023 9.61 CD40LG TNF
40 positive regulation of toll-like receptor signaling pathway GO:0034123 9.59 TLR2 TLR5
41 regulation of cytokine secretion GO:0050707 9.58 TLR2 TLR4 TLR5
42 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 MYD88 TLR2 TLR4 TNF
43 positive regulation of interleukin-8 production GO:0032757 9.46 TLR2 TLR4 TLR5 TNF
44 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CD40LG MYD88 NLRC4 TLR2 TLR4 TNF
45 inflammatory response GO:0006954 9.23 CD40LG MYD88 NAIP NLRC4 TLR2 TLR4
46 apoptotic process GO:0006915 10.06 CASP1 MYD88 NAIP NLRC4 TLR2
47 immune response GO:0006955 10 CD40LG TLR2 TLR4 TNF

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 9.32 NAIP NLRC4
2 translation elongation factor activity GO:0003746 9.26 EEF1A2 HBS1L
3 interleukin-1 receptor binding GO:0005149 9.16 MYD88 TLR5
4 Toll-like receptor binding GO:0035325 8.96 MYD88 TLR2
5 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4
Sources

Sources for Legionellosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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