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MCID: LGN002
MIFTS: 61

Legionellosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Legionellosis

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MalaCards integrated aliases for Legionellosis:

Name: Legionellosis 12 73 58 29 6 3 44 15 39 17 70
Legionnaires' Disease 70
Legionella Infection 12
Legionnaires Disease 58
Pontiac Fever 70

Characteristics:

Orphanet epidemiological data:

58
legionellosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (France); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare infectious diseases


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Summaries for Legionellosis

About this section
Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

MalaCards based summary : Legionellosis, also known as legionnaires' disease, is related to legionnaire disease and acute kidney tubular necrosis, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionellosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and Viral mRNA Translation. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, bone and lung, and related phenotypes are fatigue and fever

CDC : 3 Legionnaires' (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella.

Wikipedia : 73 Legionnaires' disease is a form of atypical pneumonia caused by any species of Legionella bacteria,... more...

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Related Diseases for Legionellosis

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Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 618)
# Related Disease Score Top Affiliating Genes
1 legionnaire disease 32.2 TLR5 SEC22B RAB1B RAB1A NLRC4 EEF1A1
2 acute kidney tubular necrosis 30.8 TNF IL6 IL18
3 bronchopneumonia 30.8 TNF TLR4 IL6 IL1B CXCL8
4 neutropenia 30.6 TNF IL6 IL1B CXCL8
5 mycoplasma pneumoniae pneumonia 30.5 TNF TLR2 IL6 IL18
6 gastroenteritis 30.4 TNF IL6 IL1B CXCL8
7 viral pneumonia 30.4 TNF IL6 CXCL8
8 invasive aspergillosis 30.4 TLR5 TLR4 TLR2 CXCL8
9 pneumonia 30.4 TNF TLR5 TLR4 TLR2 IL6 IL1B
10 pulmonary tuberculosis 30.3 TNF TLR2 IL6 IL18
11 mycobacterium marinum 30.3 TLR2 CXCL8
12 pulmonary disease, chronic obstructive 30.3 TNF TLR2 IL6 IL1B CXCL8
13 disease by infectious agent 30.3 TNF TLR4 TLR2 IL6 IL1B IL18
14 acute cystitis 30.3 TNF TLR4 IL6 IL1B IL18 CXCL8
15 respiratory failure 30.2 TNF TLR4 IL6 IL1B CXCL8
16 pericarditis 30.2 TNF IL6 IL1B CXCL8
17 bacterial pneumonia 30.2 TNF TLR4 TLR2 IL6 IL1B CXCL8
18 ileus 30.2 TNF IL6 IL1B
19 toxic shock syndrome 30.2 TNF TLR4 TLR2 IL6 IL1B CXCL8
20 haemophilus influenzae 30.2 TNF TLR2 CXCL8
21 myelitis 30.2 TNF IL6 CXCL8
22 covid-19 30.2 TNF TLR4 IL6 IL1B CXCL8
23 ulcerative colitis 30.2 TNF TLR4 IL6 IL1B CXCL8
24 diarrhea 30.2 TNF TLR4 IL6 IL1B CXCL8
25 amebiasis 30.2 TNF TLR2 IL1B CXCL8
26 myocarditis 30.1 TNF TLR4 IL6 IL1B IL18
27 infective endocarditis 30.1 TNF TLR2 IL6
28 necrotizing fasciitis 30.1 IL6 IL1B IL18 CXCL8
29 silicosis 30.1 TNF TLR4 IL1B IL18 CXCL8 CASP1
30 tularemia 30.1 TNF TLR4 TLR2 NLRC4 MYD88 IL1B
31 fasciitis 30.1 TNF IL6 IL18 CXCL8
32 extrinsic allergic alveolitis 30.1 IL6 IL1B IL18 CXCL8
33 pulmonary edema 30.1 TNF IL1B CXCL8
34 erythema multiforme 30.1 TNF IL6 CXCL8
35 pertussis 30.1 TNF TLR4 MYD88 IL6 IL1B CXCL8
36 encephalitis 30.1 TNF TLR2 IL6 IL1B
37 human cytomegalovirus infection 30.1 IL6 IL1B CXCL8
38 lyme disease 30.1 TNF TLR2 IL6 IL1B
39 acquired immunodeficiency syndrome 30.1 TNF IL6 IL1B CASP1
40 myositis 30.0 TNF IL6 IL1B CXCL8
41 toxic encephalopathy 30.0 TNF TLR4 IL6 IL1B
42 sickle cell anemia 30.0 TNF IL6 IL1B CXCL8
43 liver cirrhosis 30.0 TNF TLR4 TLR2 IL6 IL1B CXCL8
44 pharyngitis 30.0 TNF IL6 IL1B CXCL8
45 psoriatic arthritis 30.0 TNF TLR2 IL6 IL1B
46 gastric ulcer 30.0 TNF IL6 IL1B CXCL8
47 peripheral nervous system disease 30.0 TNF TLR4 IL6 IL1B CXCL8
48 influenza 30.0 TNF MYD88 IL6 IL1B CASP1
49 endocarditis 30.0 TNF TLR2 IL6 CXCL8
50 synovitis 30.0 TNF IL6 IL1B IL18 CXCL8

Graphical network of the top 20 diseases related to Legionellosis:



Diseases related to Legionellosis
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Symptoms & Phenotypes for Legionellosis

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Human phenotypes related to Legionellosis:

58 31 (show all 43)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
4 cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0012735
5 pulmonary infiltrates 58 31 hallmark (90%) Very frequent (99-80%) HP:0002113
6 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
7 arrhythmia 58 31 frequent (33%) Frequent (79-30%) HP:0011675
8 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
9 nausea and vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002017
10 ataxia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001251
11 hypotension 58 31 occasional (7.5%) Occasional (29-5%) HP:0002615
12 muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0001324
13 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
14 splenomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0001744
15 hallucinations 58 31 occasional (7.5%) Occasional (29-5%) HP:0000738
16 reduced consciousness/confusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0004372
17 proteinuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000093
18 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
19 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
20 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
21 hematuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000790
22 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
23 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
24 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
25 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
26 lymphopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001888
27 hyponatremia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002902
28 cellulitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100658
29 peripheral neuropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0009830
30 pericarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001701
31 migraine 58 31 occasional (7.5%) Occasional (29-5%) HP:0002076
32 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
33 endocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100584
34 recurrent pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100776
35 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
36 bone marrow hypocellularity 58 31 occasional (7.5%) Occasional (29-5%) HP:0005528
37 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
38 lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002716
39 pancreatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001733
40 restrictive ventilatory defect 58 31 occasional (7.5%) Occasional (29-5%) HP:0002091
41 abnormal pleura morphology 31 occasional (7.5%) HP:0002103
42 abnormality of the pleura 58 Occasional (29-5%)
43 abnormal lung morphology 58 Very frequent (99-80%)

UMLS symptoms related to Legionellosis:


fever; pruritus; snoring; coughing

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.61 CASP1
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.61 CASP1 CASP7 IL18 IL1B MYD88 NAIP
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CASP7 CXCL8 IL18 IL1B MYD88 TNF
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CASP1 CASP7 CXCL8 IL18 IL1B MYD88

MGI Mouse Phenotypes related to Legionellosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CASP1 CASP7 EEF1A1 IL18 IL1B IL6
2 immune system MP:0005387 10 CASP1 CASP7 EEF1A1 IL18 IL1B IL6
3 digestive/alimentary MP:0005381 9.92 CASP1 IL18 IL6 MYD88 TLR2 TLR4
4 mortality/aging MP:0010768 9.83 ARF1 CASP1 CASP7 EEF1A1 IL18 IL1B
5 neoplasm MP:0002006 9.23 CASP1 EEF1A1 IL1B IL6 MYD88 TLR2
Sources

Drugs & Therapeutics for Legionellosis

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Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Erythromycin Ethylsuccinate Phase 4
8 Erythromycin stearate Phase 4
9 Erythromycin Estolate Phase 4
10
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
11
Rifampicin Approved Phase 1 13292-46-1 5458213 5381226
12
Kanamycin Approved, Investigational, Vet_approved Phase 1 59-01-8, 8063-07-8 6032
13
Moxifloxacin Approved, Investigational Phase 1 151096-09-2, 354812-41-2 152946
14
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
15
Pyrazinamide Approved, Investigational Phase 1 98-96-4 1046
16
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
17
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
18 Antimetabolites Phase 1
19 Catalase Phase 1
20 Fluoroquinolones Phase 1
21 Vitamin B3 Phase 1
22 Antitubercular Agents Phase 1
23 Hypolipidemic Agents Phase 1
24 Nicotinic Acids Phase 1
25 Lipid Regulating Agents Phase 1
26 Norgestimate, ethinyl estradiol drug combination Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Pharmacokinetics of Standard First and Second Line Anti-TB Drugs in the Lung and Lesions of Subjects Elected for Resection Surgery Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
3 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Unknown status NCT03064737
4 Zithromac Iv Special Investigation For Legionella Infection. Completed NCT01784770 Azithromycin IV
5 The Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia - A Hospital Based Study in Malaysia Completed NCT03200275
6 Molecular Epidemiology of Legionellosis in Grenoble Region Completed NCT02884700
7 Prevalence of Legionella Infections, Bacterial Etiology in Pneumonia Among Patients Admitted to Hospital,- and Risk Factors/Characteristics for These Patients.(Translated From Norwegian) Completed NCT00467701
8 Legionella Pneumonia's Effect on Olfactory Function Recruiting NCT03321786
9 Nosocomial and Community Acquired Legionella Pneumophila Pneumonia, a Retrospective Case Series Recruiting NCT04106037
10 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: legionellosis

Sources

Genetic Tests for Legionellosis

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Genetic tests related to Legionellosis:

# Genetic test Affiliating Genes
1 Legionellosis 29 TLR5
Sources

Anatomical Context for Legionellosis

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The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

19
Respiratory Tract

MalaCards organs/tissues related to Legionellosis:

40
Bone, Lung, Kidney, Liver, Bone Marrow, Heart, Skin
Sources

Publications for Legionellosis

About this section

Articles related to Legionellosis:

(show top 50) (show all 1333)
# Title Authors PMID Year
1
Impaired TLR5 functionality is associated with survival in melioidosis. 6
23447684 2013
2
A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. 6
16027372 2005
3
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. 6
14623910 2003
4
Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis. 61
33587914 2021
5
Isolation and identification of Legionella spp. from hot spring water in Algeria by culture and molecular methods. 61
32985039 2021
6
[Legionelosis en España, 2010-2015]. 61
33761200 2021
7
Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999-2017. 61
33790327 2021
8
Quantification of Legionella pneumophila by qPCR and culture in tap water with different concentrations of residual disinfectants and heterotrophic bacteria. 61
33610980 2021
9
Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance? 61
33608737 2021
10
[Investigation of Legionella contamination in artificial water environment of public places and identification of its pathogenic types in Shanghai from 2011 to 2018]. 61
33455135 2021
11
Uncovering molecular targets for regenerative therapy in degenerative disc disease: do small leucine-rich proteoglycans hold the key? 61
32344061 2021
12
Legionellosis Caused by Non-Legionella pneumophila Species, with a Focus on Legionella longbeachae. 61
33572638 2021
13
Legionellosis in Japan: A Self-inflicted Wound? 61
32727982 2021
14
Novel Endosymbionts in Rhizarian Amoebae Imply Universal Infection of Unrelated Free-Living Amoebae by Legionellales. 61
33763389 2021
15
European Surveillance of Legionnaires' Disease. 61
33284133 2021
16
Genome-wide expression profiling of long non-coding RNAs and competing endogenous RNA networks in alopecia areata. 61
33525114 2020
17
Multivariate genome wide association and network analysis of subcortical imaging phenotypes in Alzheimer's disease. 61
33372590 2020
18
A Case of Legionellosis During the COVID-19 Pandemic. 61
33298818 2020
19
Genome-wide study of key genes and scoring system as potential noninvasive biomarkers for detection of suicide behavior in major depression disorder. 61
33103556 2020
20
Impact of lockdown on the microbiological status of the hospital water network during COVID-19 pandemic. 61
32976823 2020
21
Clinical profile and microbiological aetiology diagnosis in adult patients hospitalized with community-acquired pneumonia. 61
33358259 2020
22
Droplet digital PCR for the detection and monitoring of Legionella pneumophila. 61
33000184 2020
23
Epileptic Seizure after Use of Moxifloxacin in Man with Legionella longbeachae Pneumonia. 61
33079050 2020
24
Green waste compost as potential reservoirs of Legionella in the Netherlands. 61
32470567 2020
25
Prevention of nosocomial legionellosis by best water management: comparison of three decontamination methods. 61
32389709 2020
26
Legionellosis incidents associated with spa pools, England, 2002-2018. 61
32702558 2020
27
Insight into natural inhibitors and bridging docking to dynamic simulation against sugar Isomerase (SIS) domain protein. 61
32748070 2020
28
Size resolved characteristics of urban and suburban bacterial bioaerosols in Japan as assessed by 16S rRNA amplicon sequencing. 61
32699373 2020
29
Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia. 61
32560662 2020
30
Cutaneous Legionella infections in allogeneic hematopoietic cell transplantation recipients. 61
32815687 2020
31
Review Global seroprevalence of legionellosis - a systematic review and meta-analysis. 61
32355282 2020
32
What is the risk of missing legionellosis relying on urinary antigen testing solely? A retrospective Belgian multicenter study. 61
31838606 2020
33
Legionella pneumophila and Protozoan Hosts: Implications for the Control of Hospital and Potable Water Systems. 61
32326561 2020
34
Persistent Legionella contamination of water faucets in a tertiary hospital in Japan. 61
32147537 2020
35
Legionella Detection in Water Networks as per ISO 11731:2017: Can Different Filter Pore Sizes and Direct Placement on Culture Media Influence Laboratory Results? 61
32245064 2020
36
Legionella risk in evaporative cooling systems and underlying causes of associated breaches in health and safety compliance. 61
31978741 2020
37
Legionellosis and Recent Advances in Technologies for Legionella Control in Premise Plumbing Systems: A Review. 61
32704396 2020
38
Legionellosis Complicated by Invasive Aspergillosis in a Patient With Rheumatoid Arthritis. 61
32049898 2020
39
[Legionnaires' disease with pronounced cerebellar involvement: case report and literature review]. 61
32062882 2020
40
ECLS for Legionella: All Ages Welcome in the ELSO Registry. 61
30883403 2020
41
An optimized five-color/seven-parameter flow cytometry panel for immunophenotyping guinea pig peripheral blood lymphocytes. 61
31682796 2020
42
Whole genome sequence analysis reveals the broad distribution of the RtxA type 1 secretion system and four novel putative type 1 secretion systems throughout the Legionella genus. 61
31935215 2020
43
Distribution of Virulence Genes and Sequence-Based Types Among Legionella pneumophila Isolated From the Water Systems of a Tertiary Care Hospital in India. 61
33330340 2020
44
The Impact of Storms on Legionella pneumophila in Cooling Tower Water, Implications for Human Health. 61
33362725 2020
45
Can mandatory monitoring in rental apartments effectively prevent legionellosis? A retrospective analysis of data from Regensburg with a review of the literature. 61
32685358 2020
46
Impact of Chlorine and Chloramine on the Detection and Quantification of Legionella pneumophila and Mycobacterium Species. 61
31604766 2019
47
Solar and Climate Effects Explain the Wide Variation in Legionellosis Incidence Rates in the United States. 61
31519664 2019
48
Legionella and legionellosis in touristic-recreational facilities: Influence of climate factors and geostatistical analysis in Southern Italy (2001-2017). 61
31541805 2019
49
Isolation of Legionella pneumophila by Co-culture with Local Ameba, Canada. 61
31625866 2019
50
The clinical presentation of Legionella arthritis reveals the mode of infection and the bacterial species: case report and literature review. 61
31638905 2019
Sources

Variations for Legionellosis

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ClinVar genetic disease variations for Legionellosis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TLR5 NM_003268.6(TLR5):c.1174C>T (p.Arg392Ter) SNV risk factor 6658 rs5744168 GRCh37: 1:223285200-223285200
GRCh38: 1:223111858-223111858
2 TLR5 NM_003268.6(TLR5):c.1775A>G (p.Asn592Ser) SNV risk factor 6659 rs2072493 GRCh37: 1:223284599-223284599
GRCh38: 1:223111257-223111257
Sources

Expression for Legionellosis

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Search GEO for disease gene expression data for Legionellosis.
Sources

Pathways for Legionellosis

About this section

Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.11 TNF TLR5 TLR4 TLR2 SEC22B NLRC4
2
Viral mRNA Translation 65
Show member pathways
 13.87 TNF TLR4 TLR2 MYD88 IL6 IL1B
3
Akt Signaling 63
Show member pathways
 13.5 TNF TLR5 TLR4 TLR2 MYD88 IL6
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.39 TNF MYD88 IL6 IL1B IL18 CXCL8
5
PAK Pathway 63
Show member pathways
 13.35 TNF IL6 IL1B IL18 CXCL8 CASP7
6
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.27 TNF TLR5 TLR4 TLR2 MYD88 IL6
7
Human cytomegalovirus infection 36
Show member pathways
 13.04 TNF TLR4 TLR2 MYD88 IL6 IL1B
8
Measles 36
Show member pathways
 12.92 TNF TLR4 TLR2 MYD88 IL6 IL1B
9
Allograft rejection 36 1
Show member pathways
 12.88 TNF IL6 IL1B CXCL8 CASP7
10
IL-2 Pathway 63
Show member pathways
 12.87 TNF TLR5 TLR4 TLR2 MYD88 IL1B
11
Herpes simplex virus 1 infection 36
12.84 TNF TLR2 MYD88 IL6 IL1B
12
NF-KappaB Family Pathway 63
Show member pathways
 12.82 TNF TLR5 TLR4 TLR2 MYD88 IL6
13
MAPK signaling pathway 36 1
12.8 TNF MYD88 IL1B CASP7 CASP1
14
Apoptosis Modulation and Signaling 1
Show member pathways
 12.75 TNF NAIP MYD88 CASP7 CASP1
15
T cell receptor signaling pathway 36
Show member pathways
 12.71 TNF TLR4 TLR2 MYD88 IL6 IL1B
16
Th17 cell differentiation 36
Show member pathways
 12.71 TNF TLR5 TLR4 TLR2 IL6 IL1B
17
TRAF Pathway 63
Show member pathways
 12.71 TNF TLR5 TLR4 TLR2 MYD88 IL1B
18
Immune response IL-23 signaling pathway 23
Show member pathways
 12.65 TNF IL6 IL1B IL18 CASP7
19
Cytosolic sensors of pathogen-associated DNA 65
Show member pathways
 12.62 MYD88 IL6 IL1B IL18 CASP1
20
Salmonella infection (KEGG) 36
Show member pathways
 12.48 TNF TLR5 TLR4 TLR2 RAB1A NLRC4
21
IL-17 Family Signaling Pathways 64
Show member pathways
 12.46 TNF TLR5 TLR2 IL6 IL1B CXCL8
22
Toll Comparative Pathway 63
Show member pathways
 12.45 TNF TLR4 MYD88 IL6 IL1B CXCL8
23
Toxoplasmosis 36
Show member pathways
 12.39 TNF TLR4 TLR2 MYD88 IL1B EEF1A1
24
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.39 TNF TLR5 TLR4 TLR2 MYD88 IL6
25
Shigellosis 36
12.39 TNF TLR5 TLR4 NLRC4 NAIP MYD88
26
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.37 TNF IL6 IL18 CXCL8
27
Tuberculosis 36
12.35 TNF TLR4 TLR2 MYD88 IL6 IL1B
28
IL-1 Family Signaling Pathways 64
Show member pathways
 12.34 TNF TLR5 TLR2 MYD88 IL6 IL1B
29
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.34 TNF TLR5 TLR4 TLR2 NLRC4 NAIP
30
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.33 TNF IL6 IL1B IL18 CXCL8
31
C-type lectin receptor signaling pathway 36
Show member pathways
 12.32 TNF MYD88 IL6 IL1B CASP1
32
Bacterial infections in CF airways 23
Show member pathways
 12.3 TNF TLR5 TLR4 TLR2 MYD88 IL6
33
Colorectal Cancer Metastasis 63
12.29 TNF TLR5 TLR4 TLR2 IL6
34
NOD-like receptor signaling pathway 36
12.28 TNF TLR4 NLRC4 NAIP MYD88 IL6
35
Necroptosis 36
Show member pathways
 12.26 TNF TLR4 IL1B CASP1
36
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.23 TNF IL6 IL1B CXCL8
37
Yersinia infection 36
12.19 TNF TLR4 NLRC4 MYD88 IL6 IL1B
38
Spinal Cord Injury 1
12.15 TNF TLR4 IL6 IL1B CXCL8
39
Interleukin-4 and 13 signaling 65
12.12 TNF IL6 IL1B IL18 CXCL8
40
MAPK Pathway 69
Show member pathways
 12.11 TLR5 TLR4 TLR2 IL1B
41
Amoebiasis 36
12.08 TNF TLR4 TLR2 IL6 IL1B CXCL8
42
NF-kappa B signaling pathway 36
12.07 TNF TLR4 MYD88 IL1B CXCL8
43
TNF signaling pathway 36
12.06 TNF IL6 IL1B CASP7
44
Rheumatoid arthritis 36
12.02 TNF TLR4 TLR2 IL6 IL1B IL18
45
AGE-RAGE signaling pathway in diabetic complications 36
12 TNF IL6 IL1B CXCL8
46
Th17 Differentiation Pathway 64
Show member pathways
 11.99 TLR5 TLR4 TLR2 IL6 IL1B
47
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.97 TLR4 MYD88 IL6 CXCL8
48
Pertussis 36
11.92 TNF TLR4 MYD88 IL6 IL1B CXCL8
49
Th1 Differentiation Pathway 64
Show member pathways
 11.88 TNF TLR5 TLR4 TLR2 IL6 IL1B
50
Phagocytosis of Microbes 63
11.85 TLR5 TLR4 TLR2
Sources

GO Terms for Legionellosis

About this section

Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IPAF inflammasome complex GO:0072557 8.8 NLRC4 NAIP CASP1

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR5 TLR4 TLR2 MYD88 IL6 IL1B
2 immune system process GO:0002376 10.2 TLR5 TLR4 TLR2 NLRC4 NAIP MYD88
3 apoptotic process GO:0006915 10.19 TLR2 NLRC4 NAIP MYD88 IL1B CASP7
4 innate immune response GO:0045087 10.17 TLR5 TLR4 TLR2 NLRC4 NAIP MYD88
5 positive regulation of gene expression GO:0010628 10.14 TNF TLR4 TLR2 MYD88 IL6 IL1B
6 immune response GO:0006955 10.13 TNF TLR5 TLR4 TLR2 IL6 IL1B
7 cytokine-mediated signaling pathway GO:0019221 10.04 TNF MYD88 IL6 IL1B IL18 CXCL8
8 response to lipopolysaccharide GO:0032496 10.02 TLR4 TLR2 MYD88 IL1B CASP1
9 defense response to bacterium GO:0042742 10.02 TNF TLR5 TLR4 RAB1A NLRC4 NAIP
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10 TNF TLR4 MYD88 CASP1
11 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 MYD88 IL6
12 positive regulation of inflammatory response GO:0050729 9.97 TNF TLR4 TLR2 IL1B IL18
13 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.96 TNF NLRC4 CASP1 BCL2L13
14 regulation of inflammatory response GO:0050727 9.96 TNF TLR4 MYD88 CASP1
15 cellular response to mechanical stimulus GO:0071260 9.96 TLR5 TLR4 MYD88 IL1B CASP1
16 positive regulation of tumor necrosis factor production GO:0032760 9.95 TLR4 TLR2 MYD88 IL6
17 positive regulation of JNK cascade GO:0046330 9.95 TNF TLR4 MYD88 IL1B
18 positive regulation of interferon-gamma production GO:0032729 9.92 TNF TLR4 IL1B IL18
19 cellular response to lipopolysaccharide GO:0071222 9.92 TNF TLR5 TLR4 MYD88 IL6 IL1B
20 retrograde vesicle-mediated transport, Golgi to ER GO:0006890 9.91 SEC22B RAB1B RAB1A
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF MYD88 IL6 IL18
22 toll-like receptor signaling pathway GO:0002224 9.91 TLR5 TLR4 TLR2 MYD88
23 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR4 TLR2 IL1B IL18
24 regulation of insulin secretion GO:0050796 9.9 TNF IL6 IL1B
25 apoptotic signaling pathway GO:0097190 9.9 TNF TLR4 CASP1
26 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 TNF IL6 IL18
27 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 TNF TLR5 TLR4 IL1B
28 cellular response to organic cyclic compound GO:0071407 9.89 TNF IL1B IL18
29 COPII vesicle coating GO:0048208 9.88 SEC22B RAB1B RAB1A
30 positive regulation of cytokine production GO:0001819 9.88 TNF TLR5 CASP1
31 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.88 TLR5 TLR4 TLR2 MYD88
32 positive regulation of interleukin-10 production GO:0032733 9.86 TLR4 TLR2 IL6
33 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 TNF TLR4 TLR2 NLRC4 MYD88 IL6
34 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.85 TNF TLR4 MYD88 IL6
35 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF TLR4 NLRC4 IL6 CASP1
36 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR4 TLR2 MYD88 IL6 IL1B
37 negative regulation of neurogenesis GO:0050768 9.84 TNF IL6 IL1B
38 pyroptosis GO:0070269 9.82 NLRC4 NAIP CASP1
39 positive regulation of glial cell proliferation GO:0060252 9.81 TNF IL6 IL1B
40 positive regulation of interleukin-17 production GO:0032740 9.81 MYD88 IL6 IL18
41 establishment of endothelial intestinal barrier GO:0090557 9.8 RAB1B RAB1A MYD88
42 positive regulation of chemokine production GO:0032722 9.8 TNF TLR4 TLR2 MYD88 IL6
43 vascular endothelial growth factor production GO:0010573 9.76 TNF IL6 IL1B
44 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.74 TLR4 MYD88
45 virion assembly GO:0019068 9.74 RAB1B RAB1A
46 detection of bacterium GO:0016045 9.74 NLRC4 NAIP
47 I-kappaB phosphorylation GO:0007252 9.74 TLR4 TLR2
48 response to molecule of bacterial origin GO:0002237 9.73 TLR2 CXCL8
49 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.73 TNF TLR4
50 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TNF TLR5 TLR4 TLR2 SEC22B RAB1B
2 cytokine activity GO:0005125 9.35 TNF IL6 IL1B IL18 CXCL8
3 Toll-like receptor binding GO:0035325 9.32 TLR2 MYD88
4 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
5 interleukin-1 receptor binding GO:0005149 8.8 TLR5 MYD88 IL1B
Sources

Sources for Legionellosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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