Legionellosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LGN002 MIFTS: 68	Legionellosis Categories: Infectious diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Legionellosis

MalaCards integrated aliases for Legionellosis:

Name: Legionellosis ¹² ⁷⁷ ⁶⁰ ³⁰ ⁶ ⁴⁵ ¹⁵ ⁴¹ ¹⁷ ⁷⁴ ³

Legionnaires Disease ⁶⁰ ⁵⁶

Legionaire Disease, Susceptibility to ¹³

Legionnaires' Disease ⁷⁴

Legionella Infection ¹²

Pontiac Fever ⁷⁴

Characteristics:

Orphanet epidemiological data:

⁶⁰

legionellosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (France); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴ ³⁵

Certain infectious and parasitic diseases

Other bacterial diseases

Other bacterial diseases, not elsewhere classified

Legionnaires disease

Orphanet: ⁶⁰

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:10458

MeSH ⁴⁵ D007876

NCIt ⁵¹ C128334

SNOMED-CT ⁶⁹ 26726000

ICD10 ³⁴ A48.1

MESH via Orphanet ⁴⁶ D007876 D007877

ICD10 via Orphanet ³⁵ A48.1

UMLS via Orphanet ⁷⁵ C0023240 C0023241

Orphanet ⁶⁰ ORPHA549

SNOMED-CT via HPO ⁷⁰ 102594003 103370009 119248009 more

EFO ¹⁷ EFO_0007342

UMLS ⁷⁴ C0023240 C0023241 C0343528

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Summaries for Legionellosis

CDC : ³ Legionnaires’ (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. Legionella can also cause a milder illness called Pontiac fever. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella. Most people exposed to Legionella do not get sick. However, people 50 years or older, current or former smokers, and people with a weakened immune system or chronic disease are at increased risk.

MalaCards based summary : Legionellosis, also known as legionnaires disease, is related to legionnaires' disease and aspergillosis, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionellosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Erythromycin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and bone, and related phenotypes are fever and fatigue

Disease Ontology : ¹² A primary bacterial infectious disease that results in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

Wikipedia : ⁷⁷ Legionnaires'' disease, also known as legionellosis, is a form of atypical pneumonia caused by any type... more...

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Related Diseases for Legionellosis

Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)

#	Related Disease	Score	Top Affiliating Genes
1	legionnaires' disease	32.4	NLRC4 PIK3C2A TLR4 TLR5
2	aspergillosis	30.2	TLR2 TLR4 TNF
3	pertussis	30.1	IL1B TLR4 TNF
4	burns	30.0	IL1B TNF
5	q fever	30.0	IL1B TLR2 TLR4 TNF
6	pneumonia	29.9	IL1B PIK3C2A TLR2 TLR4 TLR5 TNF
7	colitis	29.9	IL1B TLR4 TNF
8	typhoid fever	29.4	CASP1 IL1B TLR4 TLR5 TNF
9	chlamydia	29.4	CASP1 IL1B TLR2 TLR4 TNF
10	psoriatic arthritis	29.4	IL1B NFKBIA TNF
11	myocardial infarction	29.1	CASP1 IL1B PIK3C2A TLR4 TNF
12	systemic lupus erythematosus	29.0	CR1 IL1B TLR2 TLR4 TLR5 TNF
13	pontiac fever	11.5
14	legionnaire disease	10.3
15	alcoholic gastritis	10.3	CASP1 IL1B
16	fungal keratitis	10.3	TLR2 TLR4
17	acute cervicitis	10.2	TLR2 TLR4
18	periodontitis, chronic	10.2	IL1B TLR2
19	familial cold autoinflammatory syndrome 1	10.2	CASP1 IL1B
20	septic arthritis	10.2	TLR2 TLR4 TLR5
21	macrophage activation syndrome	10.2	NLRC4 TNF
22	exudative glomerulonephritis	10.2	IL1B TNF
23	staphylococcal toxic shock syndrome	10.2	IL1B TNF
24	kashin-beck disease	10.2	IL1B TNF
25	vulvar vestibulitis syndrome	10.2	IL1B TNF
26	cinca syndrome	10.2	CASP1 IL1B NLRC4
27	familial cold autoinflammatory syndrome	10.2	CASP1 IL1B NLRC4
28	trench fever	10.2	TLR2 TLR4 TNF
29	penicilliosis	10.2	TLR2 TLR4 TNF
30	spondylarthropathy	10.2	TLR2 TLR4 TNF
31	glossitis	10.2	IL1B TNF
32	alveolar echinococcosis	10.2	TLR2 TLR4 TNF
33	echinococcosis	10.2	TLR2 TLR4 TNF
34	immune system disease	10.1	ARF1 TLR5 TNF
35	laryngitis	10.1	IL1B TNF
36	cardiogenic shock	10.1	PIK3C2A TNF
37	filariasis	10.1	TLR2 TLR4 TNF
38	chronic recurrent multifocal osteomyelitis	10.1	CASP1 IL1B
39	ornithosis	10.1
40	myocarditis	10.1
41	campylobacteriosis	10.1	IL1B TLR4
42	cutaneous leishmaniasis	10.1	TLR2 TLR4 TNF
43	retinitis pigmentosa 49	10.1	EEF1A2 HBS1L
44	visceral leishmaniasis	10.1	TLR2 TLR4 TNF
45	prosthetic joint infection	10.1	IL1B TLR2 TLR4
46	meningitis	10.1	IL1B TLR2 TNF
47	haemophilus influenzae	10.1	IL1B TLR2 TNF
48	cerebral artery occlusion	10.1	IL1B TNF
49	irak4 deficiency	10.1	MYD88 TLR2 TLR4 TLR5
50	congenital cytomegalovirus	10.1	IL1B TLR2 TNF

Graphical network of the top 20 diseases related to Legionellosis:

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Symptoms & Phenotypes for Legionellosis

Human phenotypes related to Legionellosis:

⁶⁰ ³³ (show all 42)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁶⁰ ³³	hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	fatigue ⁶⁰ ³³	hallmark (90%)	Very frequent (99-80%)	HP:0012378
3	myalgia ⁶⁰ ³³	hallmark (90%)	Very frequent (99-80%)	HP:0003326
4	cough ⁶⁰ ³³	hallmark (90%)	Very frequent (99-80%)	HP:0012735
5	pulmonary infiltrates ⁶⁰ ³³	hallmark (90%)	Very frequent (99-80%)	HP:0002113
6	respiratory insufficiency ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0002093
7	arrhythmia ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0011675
8	chest pain ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0100749
9	ataxia ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001251
10	muscle weakness ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001324
11	nausea and vomiting ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002017
12	encephalitis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002383
13	hypotension ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002615
14	hallucinations ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0000738
15	splenomegaly ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001744
16	reduced consciousness/confusion ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0004372
17	renal insufficiency ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0000083
18	proteinuria ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0000093
19	arthralgia ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002829
20	hepatitis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0012115
21	bone marrow hypocellularity ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0005528
22	abdominal pain ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002027
23	peripheral neuropathy ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0009830
24	abnormality of the pleura ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002103
25	jaundice ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0000952
26	pancreatitis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001733
27	anorexia ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002039
28	migraine ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002076
29	hematuria ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0000790
30	hemoptysis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002105
31	lymphopenia ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001888
32	hyponatremia ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002902
33	diarrhea ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002014
34	pericarditis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001701
35	myocarditis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0012819
36	endocarditis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0100584
37	recurrent pharyngitis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0100776
38	cellulitis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0100658
39	sepsis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0100806
40	lymphadenopathy ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002716
41	restrictive ventilatory defect ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002091
42	abnormality of lung morphology ⁶⁰		Very frequent (99-80%)

UMLS symptoms related to Legionellosis:

fever, pruritus, snoring, coughing

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.4	CASP1 IL1B MYD88 NFKBIA TNF
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.4	CASP1 IL1B MYD88 NAIP NFKBIA NLRC4

MGI Mouse Phenotypes related to Legionellosis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.1	CASP1 EEF1A2 MYD88 NFKBIA NLRC4 PIK3C2A
2	hematopoietic system	MP:0005397	10.1	CASP1 EEF1A2 HBS1L IL1B MYD88 NFKBIA
3	growth/size/body region	MP:0005378	10.07	EEF1A2 HBS1L IL1B MYD88 NFKBIA PIK3C2A
4	cardiovascular system	MP:0005385	10.03	CASP1 IL1B MYD88 PIK3C2A TLR2 TLR4
5	adipose tissue	MP:0005375	10	HBS1L MYD88 PIK3C2A TLR2 TLR4 TLR5
6	homeostasis/metabolism	MP:0005376	9.96	CASP1 HBS1L IL1B MYD88 NFKBIA PIK3C2A
7	immune system	MP:0005387	9.93	CASP1 EEF1A2 HBS1L IL1B MYD88 NFKBIA
8	mortality/aging	MP:0010768	9.7	ARF1 CASP1 EEF1A2 IL1B MYD88 NFKBIA
9	neoplasm	MP:0002006	9.1	CASP1 IL1B MYD88 TLR2 TLR4 TNF

Sources

Drugs & Therapeutics for Legionellosis

Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Erythromycin

Approved, Investigational, Vet_approved

Phase 4

114-07-8

12560 441411

Azithromycin

Approved

Phase 4

83905-01-5

55185 447043

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Norgestimate

Approved, Investigational

Phase 4,Phase 1

35189-28-7

6540478

Moxifloxacin

Approved, Investigational

Phase 4,Phase 1

354812-41-2, 151096-09-2

152946

Polyestradiol phosphate

Approved

Phase 4,Phase 1

28014-46-2

Estradiol

Approved, Investigational, Vet_approved

Phase 4,Phase 1

50-28-2

5757

Ethinyl Estradiol

Approved

Phase 4,Phase 1

57-63-6

5991

Ceftaroline fosamil

Approved, Investigational

Phase 4

229016-73-3

Ceftriaxone

Approved

Phase 4

73384-59-5

5479530 5361919

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Piperacillin

Approved

Phase 4

66258-76-2

43672

Levofloxacin

Approved, Investigational

Phase 4

100986-85-4

149096

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Tazobactam

Approved

Phase 4

89786-04-9

123630

Ofloxacin

Approved

Phase 4

82419-36-1

4583

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Anti-Bacterial Agents

Phase 4,Phase 1

Cytochrome P-450 CYP3A Inhibitors

Phase 4

Erythromycin stearate

Phase 4

Anti-Infective Agents

Phase 4,Phase 1

Antibiotics, Antitubercular

Phase 4,Phase 1

Antitubercular Agents

Phase 4,Phase 1

Erythromycin Estolate

Phase 4

Erythromycin Ethylsuccinate

Phase 4

Contraceptives, Oral, Combined

Phase 4,Phase 1

Estradiol 3-benzoate

Phase 4,Phase 1

Norgestimate, ethinyl estradiol drug combination

Phase 4,Phase 1

Estradiol 17 beta-cypionate

Phase 4,Phase 1

Topoisomerase Inhibitors

Phase 4,Phase 1

Contraceptives, Oral

Phase 4,Phase 1

Contraceptive Agents

Phase 4,Phase 1

Cephalosporins

Phase 4

Hydrocortisone hemisuccinate

Phase 4

Renal Agents

Phase 4

beta-Lactamase Inhibitors

Phase 4

Amoxicillin-Potassium Clavulanate Combination

Phase 4

Anti-Infective Agents, Urinary

Phase 4

Cytochrome P-450 CYP1A2 Inhibitors

Phase 4

Piperacillin, Tazobactam Drug Combination

Phase 4

Anti-Inflammatory Agents

Phase 4

Hydrocortisone-17-butyrate

Phase 4

Hydrocortisone 17-butyrate 21-propionate

Phase 4

Nicotinamide

Approved, Investigational

Phase 1

98-92-0

936

Pyrazinamide

Approved, Investigational

Phase 1

98-96-4

1046

Rifampicin

Approved

Phase 1

13292-46-1

5381226 5458213

Streptomycin

Approved, Vet_approved

Phase 1

57-92-1

19649

Isoniazid

Approved, Investigational

Phase 1

54-85-3

3767

Interventional clinical trials:

(show all 11)

#	Name	Status	NCT ID	Phase	Drugs
1	Aizthromycin or Clarithromycin in H-pylori Eradication Regimen	Completed	NCT01667692	Phase 4	azithromycin;clarithmycin
2	Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia	Recruiting	NCT02735707	Phase 4	Hydrocortisone;Ceftriaxone;Moxifloxacin or Levofloxacin;Piperacillin tazobactam;Ceftaroline;Amoxicillin Clavulanate;Macrolide administered for 3 days;Macrolide administered for up to 14 days
3	Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis	Completed	NCT00816426	Phase 1	Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
4	Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011.	Completed	NCT02884700
5	Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan)	Completed	NCT01784770		Azithromycin IV
6	Community Acquired Pneumonia in Telemark and Ostfold	Completed	NCT00467701
7	Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application	Completed	NCT01922024
8	Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease	Recruiting	NCT03064737	Not Applicable
9	Legionnaires' Effect on Smell	Recruiting	NCT03321786
10	Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia	Not yet recruiting	NCT03200275
11	Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis	Terminated	NCT00452153	Not Applicable

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

erythromycin pwdr

Cochrane evidence based reviews: legionellosis

Sources

Genetic Tests for Legionellosis

Genetic tests related to Legionellosis:

#	Genetic test	Affiliating Genes
1	Legionellosis ³⁰	TLR5

Sources

Anatomical Context for Legionellosis

MalaCards organs/tissues related to Legionellosis:

⁴²

Testes, Lung, Bone, Bone Marrow, Monocytes, Colon, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

²⁰

Respiratory Tract

Sources

Publications for Legionellosis

Articles related to Legionellosis:

(show top 50) (show all 1698)

#	Title	Authors	Year
1	DNA-based bioassay of legionella pneumonia pathogen using gold nanostructure: A new platform for diagnosis of legionellosis. ( 30685302 )	Mobed A...Rezaee MA	2019
2	Preventing legionellosis outbreaks by a quick detection of airborne Legionella pneumophila. ( 30763875 )	S?nchez-Parra B...Moreno DA	2019
3	A Proactive Environmental Approach for Preventing Legionellosis in Infants: Water Sampling and Antibiotic Resistance Monitoring, a 3-Years Survey Program. ( 30857147 )	Alexandropoulou I...Constantinidis TC	2019
4	Cardiovascular events and de novo AF following Legionnaires disease. ( 30686660 )	Ferreira-Coimbra J...Pereira JM	2019
5	Environmental sources of community-acquired legionnaires' disease: A review. ( 29729999 )	Orkis L.T....Stout J.E.	2018
6	Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017. ( 29744757 )	Hamilton K.A....Haas C.N.	2018
7	Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211. ( 29247056 )	Timms V.J....Sintchenko V.	2018
8	Complete Genome Sequence of<i>Legionella sainthelensi</i>Isolated from a Patient with Legionnaires' Disease. ( 29437115 )	Slow S....Cree S.	2018
9	Characterization of <i>Legionella pneumophila</i> and <i>Legionella</i> species from legionellosis patients in Japan between 2008 and 2016. ( 29980559 )	Amemura-Maekawa J....Ohnishi M.	2018
10	Fever of unknown origin due to Legionnaires' disease: A diagnostic challenge. ( 29412169 )	Kampitak T.	2018
11	Legionnaires' Disease and Use of Water Dispensers With an Ultraviolet Sterilizer. ( 29493477 )	Leung Y.H....Chuang S.K.	2018
12	Combining Environmental Investigation and a Dual-Analytical Strategy to Isolate the Legionella longbeachae Strain Linked to Two Occupational Cases of Legionellosis. ( 29304227 )	Marchand G....Lacombe N.	2018
13	The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms. ( 29572569 )	Russo A....Trigo R.M.	2018
14	Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29432149 )	Zahran S....Swanson M.S.	2018
15	The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. ( 29298342 )	Ruiz-Moreno J.S....Opitz B.	2018
16	A Case Note on Legionnaires' Disease Caused by Serogroup 1, Sequence Type ST496 in Singapore. ( 29911737 )	Chuang L....Yap J.H.	2018
17	Association Between Sporadic Legionellosis and River Systems in Connecticut. ( 29211873 )	Cassell K....Weinberger D.M.	2018
18	Legionnaires' Disease Outbreak on a Merchant Vessel, Indian Ocean, Australia, 2015. ( 29912714 )	Inglis T.J.J....Dowse G.K.	2018
19	Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )	Cunha B.A....Jimada I.	2018
20	Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015. ( 29386076 )	Lucas K.D....Mohle-Boetani J.C.	2018
21	Control and prevention measures for legionellosis in hospitals: A cross-sectional survey in Italy. ( 29864633 )	Montagna M.T....Pasquarella C.	2018
22	Lessons Learnt From Exercise Celestial Navigation: The Application of a Geographic Information System to Inform Legionnaires' Disease Control Activity. ( 29716666 )	Quinn E....Broome R.	2018
23	Of Time and the River: How Our Understanding of Legionellosis Has Changed Since 1976. ( 29211906 )	Fisman D.N.	2018
24	Correction for Zahran et al., Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29891661 )		2018
25	Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas. ( 29559643 )	MacIntyre C.R....Chughtai A.A.	2018
26	Notes from the Field: Legionellosis Outbreak Associated with a Hotel Aquatics Facility - Tennessee, 2017. ( 29346335 )	Yackley J.K....Dunn J.R.	2018
27	Rapid Identification of a Cooling Tower-Associated Legionnaires' Disease Outbreak Supported by Polymerase Chain Reaction Testing of Environmental Samples, New York City, 2014-2015. ( 29780175 )	Benowitz I....Balter S.	2018
28	Legionnaires' disease at a medical center in southern Taiwan. ( 28094205 )	Hung TL...Ko WC	2018
29	Sensitivity and Positive Predictive Value of Death Certificate Data Among Deaths Caused by Legionnaires' Disease in New York City, 2008-2013. ( 30005174 )	Tran OC...Vora NM	2018
30	Preventing Healthcare-Associated Legionellosis: Results after 3 Years of Continuous Disinfection of Hot Water with Monochloramine and an Effective Water Safety Plan. ( 30060459 )	Coniglio MA...Yassin MH	2018
31	Legionellosis Associated with Recreational Waters: A Systematic Review of Cases and Outbreaks in Swimming Pools, Spa Pools, and Similar Environments. ( 30061526 )	Leoni E...Dallolio L	2018
32	The shift in seasonality of legionellosis in the USA. ( 30099976 )	Alarcon Falconi TM...Naumova EN	2018
33	Timeliness of travel-associated Legionnaires' disease surveillance. ( 30102506 )	Robesyn E...de Jong B	2018
34	Legionellosis in Poland in 2016 ( 30111084 )	Stypu?kowska-Misiurewicz H...Czerwi?ski M	2018
35	Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: A case report. ( 30122733 )	Yoshida GJ	2018
36	Environmental surveillance of Legionella pneumophila in distal water supplies of a hospital for early identification & prevention of hospital-acquired legionellosis. ( 30168494 )	Jinna S...Gaikwad UN	2018
37	Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181540 )	Greene SK...Gutelius B	2018
38	Author Response to Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181566 )	MacIntyre CR...Chughtai AA	2018
39	Clusters of Healthcare-Associated Legionnaires' Disease in Two Hospitals of Central Greece. ( 30186646 )	Kyritsi MA...Hadjichristodoulou C	2018
40	Two Community Clusters of Legionnaires' Disease Directly Linked to a Biologic Wastewater Treatment Plant, the Netherlands. ( 30226165 )	Loenenbach AD...Brandsema PS	2018
41	Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: a case report. ( 30259881 )	Sawano T...Kambe T	2018
42	Preventing hospital-acquired Legionnaires' disease: A snapshot of clinical practices and water management approaches in US acute-care hospitals. ( 30293535 )	Ehret KM...Fridkin SK	2018
43	Simulation of Legionnaires' disease prospective spatiotemporal cluster detection, Allegheny County, Pennsylvania, USA. ( 30334502 )	Orkis LT...Greene SK	2018
44	Legionella and Legionnaires' disease: Time to explore in India. ( 30429383 )	Chaudhry R...Valavane A	2018
45	Travel-associated Legionnaires' disease: would changing cluster definition lead to the prevention of a larger number of cases? ( 30501676 )	Rota MC...Crespi S	2018
46	A community outbreak of Legionnaires' disease in Geneva, Switzerland, June to September 2017. ( 30552854 )	Zanella MC...Kaiser L	2018
47	Improvement of Legionnaires' disease diagnosis using real-time PCR assay: a retrospective analysis, Italy, 2010 to 2015. ( 30563592 )	Ricci ML...Scaturro M	2018
48	Why Are Legionnaires Disease Diagnoses Becoming More Common in the United States? ( 29641815 )	Rubin R	2018
49	New approach to environmental investigation of an explosive legionnaires´ disease outbreak in Spain: early identification of potential risk sources by rapid Legionella spp immunosensing technique. ( 30587144 )	Cebri?n F...Fern?ndez PJ	2018
50	Prevention of Health Care-Associated Legionnaires Disease. ( 30646069 )	Skerrett SJ	2018

Sources

Genes for Legionellosis

Genes related to Legionellosis (1 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	TLR5	Toll Like Receptor 5	Protein Coding	161.29	Genetic Tests ³⁰ Protective ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Pathways & Interactions Variants (show sections)	14623910 16027372 23447684 (more) 14623910 15747241
2	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	23.74	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
3	CASP1	Caspase 1	Protein Coding	22.89	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
4	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	22.02	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶	18482636
5	TLR2	Toll Like Receptor 2	Protein Coding	21.91	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
6	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	21.81	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
7	ARF1	ADP Ribosylation Factor 1	Protein Coding	21.69	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
8	HBS1L	HBS1 Like Translational GTPase	Protein Coding	21.64	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
9	TLR4	Toll Like Receptor 4	Protein Coding	21.62	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
10	TNF	Tumor Necrosis Factor	Protein Coding	21.41	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
11	NAIP	NLR Family Apoptosis Inhibitory Protein	Protein Coding	21.23	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
12	IL1B	Interleukin 1 Beta	Protein Coding	21.09	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
13	EEF1A2	Eukaryotic Translation Elongation Factor 1 Alpha 2	Protein Coding	20.9	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
14	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	20.61	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)
15	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	20.56	DISEASES inferred ¹⁵ GeneCards inferred via : Pathways & Interactions (show sections)

Sources

Variations for Legionellosis

ClinVar genetic disease variations for Legionellosis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	TLR5	NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser)	single nucleotide variant	risk factor	rs2072493	GRCh38	Chromosome 1, 223111257: 223111257
2	TLR5	NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser)	single nucleotide variant	risk factor	rs2072493	GRCh37	Chromosome 1, 223284599: 223284599
3	TLR5	NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter)	single nucleotide variant	protective,risk factor	rs5744168	GRCh38	Chromosome 1, 223111858: 223111858
4	TLR5	NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter)	single nucleotide variant	protective,risk factor	rs5744168	GRCh37	Chromosome 1, 223285200: 223285200

Sources

Expression for Legionellosis

Search GEO for disease gene expression data for Legionellosis.

Sources

Pathways for Legionellosis

Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	14	ARF1 CASP1 CR1 IL1B MYD88 NFKBIA
2	Akt Signaling ⁶⁵ Show member pathways p38 Signaling ⁶⁵ Tec Kinases Signaling ⁶⁵	13.34	IL1B MYD88 TLR2 TLR4 TLR5 TNF
3	IL-2 Pathway ⁶⁵ Show member pathways ErbB Family Pathway ⁶⁵ ErbB2-ErbB3 Heterodimers ⁶⁵ ErbB4 Pathway ⁶⁵ Growth Hormone Signaling ⁶⁵ HMGB1 Pathway ⁶⁵ IL-4 Pathway ⁶⁵ LPS Stimulated MAPK Signaling ⁶⁵ PACAP Signaling ⁶⁵ PI3K Signaling in B-Lymphocyte ⁶⁵ Prolactin Signaling ⁶⁵ Thrombopoietin Pathway ⁶⁵ TREM1 Pathway ⁶⁵ UVC-Induced MAPK Signaling ⁶⁵	13.2	IL1B MYD88 NFKBIA PIK3C2A TLR2 TLR4
4	Human cytomegalovirus infection ³⁸ Show member pathways Human immunodeficiency virus 1 infection ³⁸ Kaposi sarcoma-associated herpesvirus infection ³⁸	12.96	IL1B MYD88 NFKBIA TLR2 TLR4 TNF
5	Toll-like Receptor Signaling Pathway ³⁸ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁸ Epstein-Barr virus infection ³⁸ Hepatitis B ³⁸ Hepatitis C ³⁸ NOD-like Receptor Signaling Pathways ⁶⁶ Regulation of toll-like receptor signaling pathway ¹	12.88	CASP1 IL1B MYD88 NAIP NFKBIA NLRC4
6	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁸ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²³ Apoptosis Signaling Pathways ⁶⁶ Death Receptor Signaling ⁶⁸	12.79	CASP1 MYD88 NAIP NFKBIA TNF
7	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁷ Show member pathways Cytosolic DNA-sensing pathway ³⁸ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Negative regulators of RIG-I/MDA5 signaling ⁶⁷ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁷ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁸ TRAF3-dependent IRF activation pathway ⁶⁷ TRAF6 mediated IRF7 activation ⁶⁷ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁶	12.77	CASP1 IL1B MYD88 NFKBIA TLR4 TNF
8	NF-KappaB Family Pathway ⁶⁵ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁵	12.7	IL1B MYD88 NFKBIA TLR2 TLR4 TLR5
9	Th17 cell differentiation ³⁸ Show member pathways IL-22 Pathway ⁶⁵ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease (IBD) ³⁸ Th1 and Th2 cell differentiation ³⁸	12.6	IL1B NFKBIA TLR2 TLR4 TLR5 TNF
10	NF-kappaB Signaling ⁴	12.58	IL1B MYD88 NFKBIA TLR2 TNF
11	Influenza A ³⁸ Show member pathways Measles ³⁸	12.58	CASP1 IL1B MYD88 NFKBIA TLR2 TLR4
12	TRAF Pathway ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁵ TNF Superfamily Pathway ⁶⁵ Toll-Like Receptors Pathway ⁶⁵	12.57	CASP1 IL1B MYD88 NFKBIA TLR2 TLR4
13	VEGF Pathway (Qiagen) ⁶⁵ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁵ Development VEGF-family signaling ²³ Neurophilin interactions with VEGF and VEGFR ⁶⁷ VEGF Pathway ⁶⁵	12.43	MYD88 NFKBIA TLR2 TLR4 TLR5
14	IL-17 Family Signaling Pathways ⁶⁶ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁸ Interleukin-17 signaling ⁶⁷ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.35	IL1B NFKBIA TLR2 TLR5 TNF
15	Toll Comparative Pathway ⁶⁵ Show member pathways IL-1 Pathway ⁶⁵ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶⁵ TLR-TRIF Pathway ⁶⁵	12.34	IL1B MYD88 NFKBIA TLR4 TNF
16	IL-1 signaling pathway ¹ Show member pathways IL1-mediated signaling events ¹ Interleukin-1 signaling ⁶⁷ MAP3K8 (TPL2)-dependent MAPK1/3 activation ⁶⁷ Structural Pathway of Interleukin 1 (IL-1) ¹	12.3	CASP1 IL1B MYD88 NFKBIA
17	Diseases associated with the TLR signaling cascade ⁶⁷ Show member pathways Diseases of Immune System ⁶⁷ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁷ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁷ IRAK4 deficiency (TLR2/4) ⁶⁷ IRAK4 deficiency (TLR5) ⁶⁷ MyD88 deficiency (TLR2/4) ⁶⁷ MyD88 deficiency (TLR5) ⁶⁷ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.28	MYD88 NFKBIA TLR2 TLR4 TLR5 TNF
18	C-type lectin receptor signaling pathway ³⁸ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁶	12.23	CASP1 IL1B MYD88 NFKBIA TNF
19	Necroptosis ³⁸ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.22	CASP1 IL1B TLR4 TNF
20	Tuberculosis ³⁸	12.22	CR1 IL1B MYD88 TLR2 TLR4 TNF
21	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	12.2	IL1B MYD88 TLR2 TLR4 TLR5
22	Colorectal Cancer Metastasis ⁶⁵	12.2	TLR2 TLR4 TLR5 TNF
23	IL-1 Family Signaling Pathways ⁶⁶ Show member pathways Immune response IL-1 signaling pathway ²³ Mucin expression in CF via TLRs, EGFR signaling pathways ²³	12.2	IL1B MYD88 NFKBIA TLR2 TLR5 TNF
24	Toxoplasmosis ³⁸ Show member pathways Leishmaniasis ³⁸	12.14	CR1 IL1B MYD88 NFKBIA TLR2 TLR4
25	Th1 Differentiation Pathway ⁶⁶ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁶	12.08	IL1B TLR2 TLR4 TLR5 TNF
26	Microglia Activation During Neuroinflammation: Overview ⁶⁶ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁶	12.06	IL1B TLR2 TLR4 TNF
27	MAPK Pathway ⁷³ Show member pathways Toll-like Receptor Pathway ⁷³	12.03	IL1B NFKBIA PIK3C2A TLR2 TLR4 TLR5
28	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.02	IL1B MYD88 NFKBIA TLR2 TLR4 TLR5
29	Osteoclast differentiation ³⁸	11.99	IL1B NFKBIA TNF
30	Spinal Cord Injury ¹	11.96	IL1B TLR4 TNF
31	Amoebiasis ³⁸	11.93	IL1B TLR2 TLR4 TNF
32	TNF signaling pathway ³⁸	11.92	IL1B NFKBIA TNF
33	NF-kappa B signaling pathway ³⁸	11.92	IL1B MYD88 NFKBIA TLR4 TNF
34	Rheumatoid arthritis ³⁸	11.89	IL1B TLR2 TLR4 TNF
35	Hematopoietic cell lineage ³⁸	11.87	CR1 IL1B TNF
36	Phagocytosis of Microbes ⁶⁵	11.86	CR1 TLR2 TLR4 TLR5
37	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.84	MYD88 NFKBIA TLR4
38	Pertussis ³⁸	11.79	CASP1 IL1B MYD88 TLR4 TNF
39	Salmonella infection (KEGG) ³⁸	11.78	CASP1 IL1B MYD88 NLRC4 TLR4 TLR5
40	NF-kB (NFkB) Pathway ⁶⁸	11.77	MYD88 NFKBIA TLR4 TNF
41	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.67	IL1B NFKBIA TNF
42	Transcription_NF-kB signaling pathway ²³	11.62	MYD88 NFKBIA TLR4 TNF
43	MSP-RON Signaling ⁶⁵	11.56	IL1B TLR2 TLR4 TNF
44	African trypanosomiasis ³⁸	11.42	IL1B MYD88 TNF
45	Nucleotide-binding Oligomerization Domain (NOD) pathway ¹	11.41	CASP1 IL1B NAIP NFKBIA NLRC4
46	IL-10 Pathway ⁶⁵	11.39	IL1B TLR4 TNF
47	IL1 and megakaryocytes in obesity ¹	11.23	IL1B MYD88 TLR2
48	Legionellosis ³⁸	11.21	ARF1 CASP1 CR1 EEF1A2 HBS1L IL1B
49	Cellular roles of Anthrax toxin ¹	11.17	CASP1 IL1B TNF
50	NTHi-Induced Signaling ⁶⁵	11.14	MYD88 NFKBIA TLR2

Sources

GO Terms for Legionellosis

Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IPAF inflammasome complex	GO:0072557	8.62	CASP1 NLRC4

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	9.98	CR1 MYD88 NAIP NLRC4 TLR2 TLR4
2	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.95	CASP1 IL1B MYD88 TLR4 TNF
3	response to lipopolysaccharide	GO:0032496	9.93	IL1B MYD88 NFKBIA TLR2 TLR4
4	cellular response to lipopolysaccharide	GO:0071222	9.92	CASP1 IL1B TLR4 TLR5 TNF
5	activation of MAPK activity	GO:0000187	9.89	IL1B TLR4 TNF
6	cellular response to interferon-gamma	GO:0071346	9.88	CASP1 TLR2 TLR4
7	defense response to Gram-positive bacterium	GO:0050830	9.88	MYD88 TLR2 TNF
8	positive regulation of JNK cascade	GO:0046330	9.88	IL1B MYD88 TLR4 TNF
9	positive regulation of inflammatory response	GO:0050729	9.88	NFKBIA TLR2 TLR4 TNF
10	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	9.87	CASP1 NLRC4 TNF
11	regulation of inflammatory response	GO:0050727	9.85	MYD88 TLR4 TNF
12	apoptotic signaling pathway	GO:0097190	9.84	CASP1 TLR4 TNF
13	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.84	NFKBIA TLR4 TNF
14	positive regulation of tumor necrosis factor production	GO:0032760	9.83	MYD88 TLR2 TLR4
15	interleukin-1-mediated signaling pathway	GO:0070498	9.82	IL1B MYD88 NFKBIA
16	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.81	IL1B TLR2 TLR4 TNF
17	positive regulation of interferon-gamma production	GO:0032729	9.8	IL1B TLR4 TNF
18	toll-like receptor signaling pathway	GO:0002224	9.79	MYD88 TLR2 TLR4
19	positive regulation of chemokine production	GO:0032722	9.77	TLR2 TLR4 TNF
20	cellular response to mechanical stimulus	GO:0071260	9.77	CASP1 IL1B MYD88 TLR4 TLR5
21	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.76	IL1B TLR4 TLR5 TNF
22	inflammatory response	GO:0006954	9.76	IL1B MYD88 NAIP NLRC4 TLR2 TLR4
23	regulation of cytokine secretion	GO:0050707	9.74	TLR2 TLR4 TLR5
24	activation of innate immune response	GO:0002218	9.73	NLRC4 TLR4
25	microglial cell activation	GO:0001774	9.73	TLR2 TNF
26	negative regulation of lipid catabolic process	GO:0050995	9.73	IL1B TNF
27	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.73	IL1B MYD88 NLRC4 TLR2 TLR4 TNF
28	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.72	MYD88 TLR4
29	positive regulation of glial cell proliferation	GO:0060252	9.72	IL1B TNF
30	regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043122	9.72	IL1B TNF
31	toll-like receptor 4 signaling pathway	GO:0034142	9.72	NFKBIA TLR4
32	positive regulation of interleukin-6 production	GO:0032755	9.72	IL1B MYD88 TLR2 TLR4 TNF
33	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.71	IL1B TNF
34	negative regulation of growth of symbiont in host	GO:0044130	9.71	MYD88 TNF
35	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.71	IL1B TNF
36	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.71	TLR2 TLR4
37	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.71	MYD88 TLR2 TLR4 TLR5
38	I-kappaB phosphorylation	GO:0007252	9.7	TLR2 TLR4
39	cellular response to lipoteichoic acid	GO:0071223	9.69	TLR2 TLR4
40	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.69	TLR4 TNF
41	negative regulation of lipid storage	GO:0010888	9.68	NFKBIA TNF
42	positive regulation of lymphocyte proliferation	GO:0050671	9.68	MYD88 TLR4
43	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.68	MYD88 TLR4
44	interleukin-1 beta secretion	GO:0050702	9.68	NLRC4 TLR4
45	regulation of establishment of endothelial barrier	GO:1903140	9.67	IL1B TNF
46	positive regulation of neuroinflammatory response	GO:0150078	9.66	IL1B TNF
47	positive regulation of fever generation	GO:0031622	9.65	IL1B TNF
48	positive regulation of chemokine biosynthetic process	GO:0045080	9.65	IL1B MYD88 TNF
49	positive regulation of toll-like receptor signaling pathway	GO:0034123	9.63	TLR2 TLR5
50	sequestering of triglyceride	GO:0030730	9.63	IL1B TNF

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.5	CASP1 MYD88 NFKBIA NLRC4 TLR2 TLR4
2	translation elongation factor activity	GO:0003746	9.32	EEF1A2 HBS1L
3	Toll-like receptor binding	GO:0035325	9.26	MYD88 TLR2
4	lipopolysaccharide receptor activity	GO:0001875	9.16	TLR2 TLR4
5	interleukin-1 receptor binding	GO:0005149	8.8	IL1B MYD88 TLR5

Sources

Sources for Legionellosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Legionellosis

Aliases & Classifications for Legionellosis

MalaCards integrated aliases for Legionellosis:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Legionellosis

Related Diseases for Legionellosis

Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Legionellosis:

Symptoms & Phenotypes for Legionellosis

Human phenotypes related to Legionellosis:

UMLS symptoms related to Legionellosis:

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Legionellosis:

Drugs & Therapeutics for Legionellosis

Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: legionellosis

Genetic Tests for Legionellosis

Genetic tests related to Legionellosis:

Anatomical Context for Legionellosis

MalaCards organs/tissues related to Legionellosis:

The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

Publications for Legionellosis

Articles related to Legionellosis:

Genes for Legionellosis

Genes related to Legionellosis (1 elite genes):

Variations for Legionellosis

ClinVar genetic disease variations for Legionellosis:

Expression for Legionellosis

Pathways for Legionellosis

Pathways related to Legionellosis according to GeneCards Suite gene sharing:

GO Terms for Legionellosis

Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

Sources for Legionellosis

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :