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MCID: LGN002
MIFTS: 49

Legionellosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Legionellosis

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MalaCards integrated aliases for Legionellosis:

Name: Legionellosis 11 58 75 2 43 14 38 16 71 75 33
Legionella Infection 11 58 33
Infection by Legionella Pneumophilia 33
Legionella Pneumophila Infection 33
Legionnaires' Disease 71
Pontiac Fever 71

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD11: 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 11 DOID:10458
MeSH 43 D007876
NCIt 49 C128334
SNOMED-CT 68 26726000
Orphanet 58 ORPHA600832
ICD11 33 390042715
UMLS 71 C0023240 C0023241 C0343528
Sources

Summaries for Legionellosis

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Disease Ontology: 11 A primary bacterial infectious disease that results in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

MalaCards based summary: Legionellosis, also known as legionella infection, is related to pontiac fever and pneumonia, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionellosis is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Metabolism of proteins and Innate Immune System. The drugs Azithromycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract, lung and bone marrow, and related phenotype is mortality/aging.

CDC: 2 Legionnaires' (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella.

Wikipedia: 75 Legionnaires' disease is a form of atypical pneumonia caused by any species of Legionella bacteria,... more...
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Related Diseases for Legionellosis

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Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)
# Related Disease Score Top Affiliating Genes
1 pontiac fever 32.3 SEC22B RAB1B ARSD ANK2
2 pneumonia 31.1 TNF TLR2 IL1B CRP CD40LG
3 legionnaire disease 31.1 TNF TLR5 TLR2 SEC22B RAB8A RAB5A
4 bacterial pneumonia 30.7 TNF TLR2 IL1B CRP
5 pleurisy 30.7 TNF IL1B CRP
6 listeriosis 30.6 TNF TLR2 IL1B
7 pancreatitis 30.6 TNF IL1B CRP CASP1
8 lung abscess 30.6 TNF IL1B CRP
9 invasive aspergillosis 30.6 TNF TLR2 CRP
10 acute pancreatitis 30.6 TNF IL1B CRP CASP1
11 toxic shock syndrome 30.5 TNF TLR2 IL1B CRP
12 alcoholic hepatitis 30.5 TNF TLR2 IL1B CRP
13 peritonitis 30.5 TNF TLR2 IL1B CRP
14 aspergillosis 30.4 TNF TLR5 TLR2 IL1B
15 pericarditis 30.4 TNF IL1B CRP
16 inflammatory bowel disease 1 30.4 TNF TLR2 NOD1 IL1B
17 ulcerative colitis 30.3 TNF TLR2 IL1B CRP
18 alcohol use disorder 30.3 TNF IL1B CRP
19 acute myocarditis 30.3 TNF IL1B CRP
20 bronchitis 30.3 TNF TLR2 IL1B CRP
21 pneumocystosis 30.3 TNF CRP CD40LG
22 common cold 30.3 TNF IL1B CRP CD40LG
23 purpura 30.3 TNF IL1B CRP
24 endocarditis 30.2 TNF TLR2 CRP
25 aspiration pneumonia 30.2 TNF IL1B CRP
26 haemophilus influenzae 30.2 TNF TLR2 IL1B
27 exanthem 30.2 TNF IL1B CRP
28 spondyloarthropathy 1 30.1 TNF IL1B CRP CD40LG
29 glomerulonephritis 30.1 TNF IL1B CRP CD40LG
30 q fever 30.1 TNF TLR2 IL1B
31 chlamydia 30.1 TNF TLR2 NOD1 IL1B CRP CASP1
32 pharyngitis 30.1 TNF TLR2 IL1B CRP
33 leptospirosis 30.1 TNF TLR2 IL1B CRP
34 adult-onset still's disease 30.1 TNF NLRC4 IL1B CRP CASP1
35 toxoplasmosis 30.1 TNF TLR5 IL1B CD40LG CASP1
36 acquired immunodeficiency syndrome 30.1 TNF IL1B CRP CD40LG CASP1
37 psoriatic arthritis 30.1 TNF TLR2 IL1B CRP
38 pulmonary disease, chronic obstructive 30.0 TNF TLR2 IL1B CRP
39 lyme disease 30.0 TNF TLR2 IL1B CRP CD40LG
40 plague 30.0 TNF TLR5 TLR2 IL1B CASP1
41 juvenile rheumatoid arthritis 30.0 TNF IL1B CRP
42 crohn's disease 30.0 TNF TLR2 NOD1 IL1B CRP
43 colitis 29.9 TNF TLR5 TLR2 NOD1 IL1B CRP
44 immune deficiency disease 29.7 TNF TLR2 IL1B CRP CD40LG
45 inflammatory bowel disease 29.7 TNF TLR5 TLR2 NOD1 IL1B CRP
46 house allergic alveolitis 11.0
47 enterocolitis 10.4 TNF NLRC4 CRP
48 anterior scleritis 10.4 TNF CRP
49 posterior scleritis 10.4 TNF CRP
50 rheumatoid arthritis interstitial lung disease 10.4 TNF CRP

Graphical network of the top 20 diseases related to Legionellosis:



Diseases related to Legionellosis
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Symptoms & Phenotypes for Legionellosis

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UMLS symptoms related to Legionellosis:


fever; pruritus; snoring; coughing

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 ANK2 ANKLE1 ARF1 ARSD CASP1 CD40LG
2 no effect GR00402-S-2 10.2 ANK2 ANKLE1 ARF1 ARSD CASP1 CD40LG

MGI Mouse Phenotypes related to Legionellosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.47 ANK2 ANKLE1 ARF1 CASP1 CD40LG IL1B
Sources

Drugs & Therapeutics for Legionellosis

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Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved 83905-01-5 447043
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Molecular Epidemiology of Legionellosis in Grenoble Region Completed NCT02884700
2 Nosocomial and Community Acquired Legionella Pneumophila Pneumonia, a Retrospective Case Series Completed NCT04106037
3 Zithromac Iv Special Investigation For Legionella Infection. Completed NCT01784770 Azithromycin IV
4 The Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia - A Hospital Based Study in Malaysia Completed NCT03200275
5 Legionella Pneumonia's Effect on Olfactory Function Recruiting NCT03321786
6 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Recruiting NCT03064737
7 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: legionellosis

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Genetic Tests for Legionellosis

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Anatomical Context for Legionellosis

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Organs/tissues related to Legionellosis:

FMA: Respiratory Tract
MalaCards : Lung, Bone Marrow, Myeloid, Monocytes, Nk Cells, T Cells, Heart
Sources

Publications for Legionellosis

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Articles related to Legionellosis:

(show top 50) (show all 1801)
# Title Authors PMID Year
1
Temporal trends in legionellosis national notification data and the effect of COVID-19, Switzerland, 2000-2020. 62
35508422 2023
2
Systematic active environmental surveillance successfully identified and controlled the Legionella contamination in the hospital. 62
36162645 2023
3
Effect of the COVID-19 pandemic and state of emergency declarations on the relative incidence of legionellosis and invasive pneumococcal disease in Japan. 62
36116719 2023
4
Can legionellosis be considered an occupational risk in the healthcare sector? A systematic review and meta-analysis. 62
36463752 2022
5
Legionellosis risk-an overview of Legionella spp. habitats in Europe. 62
36161570 2022
6
Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection. 62
36427489 2022
7
The Effect Citrox BCL on Legionella pneumophila Mechanisms of Biofilm Formation, Oxidative Stress and Virulence. 62
36358558 2022
8
Environmental Investigation during Legionellosis Outbreak, Montérégie, Quebec, Canada, 2021. 62
36286248 2022
9
Meteorological conditions and Legionnaires' disease sporadic cases-a systematic review. 62
35964674 2022
10
Chromosome-scale assemblies of Acanthamoeba castellanii genomes provide insights into Legionella pneumophila infection-related chromatin reorganization. 62
36109147 2022
11
Lung Ultrasound Monitoring of Legionella Ventilator-Associated Pneumonia in an Extremely Low-Birth-Weight Infant. 62
36140654 2022
12
Assessment of the risk of Legionella pneumophila in water distribution systems in hospitals of Tehran city. 62
36175694 2022
13
Clinical profile and microbiological aetiology diagnosis in adult patients hospitalized with community-acquired pneumonia. 62
33358259 2022
14
RNA-Seq Reveals Protective Mechanisms of Mongolian Medicine Molor-Dabos-4 on Acute Indomethacin-Induced Gastric Ulcers in Rats. 62
36292625 2022
15
Serological review of Bartonella henselae and Bartonella quintana infection among Malaysian patients with unknown causes of febrile illnesses. 62
36214431 2022
16
Notifiable Infectious Diseases Among Organ Transplant Recipients: A Data-Linked Cohort Study, 2000-2015. 62
35937651 2022
17
Epidemiology and direct health care costs of hospitalised legionellosis in New Zealand, 2000-2020. 62
36038465 2022
18
Surveillance of hospital water systems to help predict the risk of nosocomial legionellosis-Consider other factors. 62
34121646 2022
19
Use of a Novel DNA-Loaded Alginate-Calcium Carbonate Biopolymer Surrogate to Study the Engulfment of Legionella pneumophila by Acanthamoeba polyphaga in Water Systems. 62
35950853 2022
20
Factors That Affect Legionella Positivity in Healthcare Building Water Systems from a Large, National Environmental Surveillance Initiative. 62
35929739 2022
21
Tailored approach to study Legionella infection using a lattice light sheet microscope (LLSM). 62
36032581 2022
22
Hot water plumbing in residences and office buildings have distinctive risk of Legionella pneumophila contamination. 62
36058110 2022
23
Legionella pneumophila Infection of Human Macrophages Retains Golgi Structure but Reduces O-Glycans. 62
36015029 2022
24
An application for relating Legionella shower water monitoring results to estimated health outcomes. 62
35816914 2022
25
Cerebellar syndrome associated with legionellosis: A case report and literature review. 62
35643782 2022
26
Risk of Legionellosis in residential areas around farms irrigating with municipal wastewater. 62
35840056 2022
27
Epidemiological and clinical characteristics of legionellosis in Northern Australia, 2010-2021. 62
35739069 2022
28
The Triad of Legionnaires' Disease, Rhabdomyolysis, and Acute Kidney Injury: A Case Report. 62
35655418 2022
29
Legionnaires' Disease: Update on Diagnosis and Treatment. 62
35505000 2022
30
Acute fibrinous and organizing pneumonia in a patient with Sjögren's syndrome and Legionella pneumonia: a case report and literature review. 62
35610634 2022
31
Incidence and influence of hyperCKemia in Legionella infection. 62
35405618 2022
32
Four-Year Environmental Surveillance Program of Legionella spp. in One of Palermo's Largest Hospitals. 62
35456814 2022
33
Characterization of reported legionellosis outbreaks associated with buildings served by public drinking water systems: United States, 2001-2017. 62
35482386 2022
34
Potential environmental and health risk when returning to normal amidst COVID-19 vaccination. 62
35155880 2022
35
The Collateral Effect of COVID-19 on the Epidemiology of Airborne/Droplet-Transmitted Notifiable Infectious Diseases in Taiwan. 62
35453229 2022
36
Isolation and identification of Legionella spp. from non-hospital facilities: a preliminary one-year surveillance study in the urban area of Pesaro-Urbino (Central Italy). 62
35088824 2022
37
Blockade of Cycloxygenase-2 ameliorates sepsis induced immune-suppression by regulating myeloid-derived suppressor cells. 62
35008007 2022
38
Diagnostic accuracy of urinary antigen tests for legionellosis: A systematic review and meta-analysis. 62
34972680 2022
39
Learning Ability and Hippocampal Transcriptome Responses to Early and Later Life Environmental Complexities in Dual-Purpose Chicks. 62
35268235 2022
40
Development and Evaluation of Statewide Prospective Spatiotemporal Legionellosis Cluster Surveillance, New Jersey, USA. 62
35202521 2022
41
Risk Exposure to Legionella pneumophila during Showering: The Difference between a Classical and a Water Saving Shower System. 62
35328980 2022
42
Overview of the Clinical and Molecular Features of Legionella Pneumophila: Focus on Novel Surveillance and Diagnostic Strategies. 62
35326833 2022
43
Detection performance of PCR for Legionella pneumophila in environmental samples: a systematic review and meta-analysis. 62
35303873 2022
44
Global Perspective of Legionella Infection in Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies. 62
35162928 2022
45
Probabilistic Analysis of a French Legionellosis Outbreak Shows Potential Role of Wastewater Basin. 62
35208875 2022
46
National survey of physicians in Japan regarding their use of diagnostic tests for legionellosis. 62
34933785 2022
47
Identifying chemolithotrophic and pathogenic-related gene expression within suspended sediment flocs in freshwater environments: A metatranscriptomic assessment. 62
34656597 2022
48
In silico structure evaluation of BAG3 and elucidating its association with bacterial infections through protein-protein and host-pathogen interaction analysis. 62
33998043 2022
49
Incidence of common infectious diseases in Japan during the COVID-19 pandemic. 62
35020724 2022
50
Multi-Omics Reveals That the Rumen Transcriptome, Microbiome, and Its Metabolome Co-regulate Cold Season Adaptability of Tibetan Sheep. 62
35495720 2022
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Variations for Legionellosis

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Expression for Legionellosis

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Search GEO for disease gene expression data for Legionellosis.
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Pathways for Legionellosis

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Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Metabolism of proteins 66
Show member pathways
 13.85 SEC22B RAB8A RAB5A RAB33B RAB1B RAB1A
2
Innate Immune System 66
Show member pathways
 13.85 TNF TLR5 TLR2 SEC22B NOD1 NLRC4
3
Vesicle-mediated transport 66
Show member pathways
 13.03 SEC22B RAB8A RAB5A RAB33B RAB1B RAB1A
4
Golgi-to-ER retrograde transport 66
Show member pathways
 12.96 SEC22B RAB5A RAB33B RAB1B RAB1A ARF1
5
Sertoli-Sertoli Cell Junction Dynamics 64
Show member pathways
 12.65 TNF SEC22B RAB8A RAB5A RAB33B RAB1B
6
NF-KappaB Family Pathway 64
Show member pathways
 12.59 TNF TLR5 TLR2 IL1B CD40LG
7
NF-kappaB Signaling 3
12.44 TNF TLR2 NOD1 IL1B CD40LG
8
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 65
Show member pathways
 12.39 CASP1 CD40LG IL1B TLR2 TLR5 TNF
9
Autophagy pathway 67
Show member pathways
 12.32 RAB8A RAB5A RAB1B RAB1A
10
Rab regulation of trafficking 66
Show member pathways
 12.29 RAB8A RAB5A RAB33B RAB1B RAB1A
11
Apoptosis and Autophagy 3
Show member pathways
 12.26 TNF NOD1 CD40LG CASP1
12
Bacterial infections in CF airways 22
Show member pathways
 12.25 TNF TLR5 TLR2 IL1B CASP1
13
COPII-mediated vesicle transport 66
Show member pathways
 11.82 SEC22B RAB1B RAB1A
14
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 66
Show member pathways
 11.79 NOD1 NLRC4 CASP1
15
Allograft rejection 74
11.78 TNF IL1B CD40LG
16
Th17 Differentiation 65
Show member pathways
 11.76 TLR5 TLR2 IL1B
17
IL27-mediated signaling events 61
Show member pathways
 11.73 TNF TLR5 TLR2 IL1B
18
Toll-Like receptor Signaling Pathways 65
Show member pathways
 11.66 TNF TLR5 TLR2 NOD1 NLRC4 IL1B
19
Extrafollicular B cell activation by SARS-CoV-2 74
11.64 TNF CRP CD40LG
20
Photodynamic therapy-induced NF-kB survival signaling 74
Show member pathways
 11.58 TNF IL1B CD40LG
21
IL 10 signaling pathway 67
11.56 TNF IL1B CD40LG
22
Inflammatory bowel disease signaling 74
Show member pathways
 11.52 TNF TLR5 TLR2
23
MSP-RON Signaling 64
11.39 IL1B TLR2 TNF
24
Amyotrophic lateral sclerosis (ALS) 74
11.24 TNF RAB5A CASP1
25
RAB geranylgeranylation 66
11.17 RAB8A RAB5A RAB33B RAB1B RAB1A
26
Prostaglandin signaling 74
11.12 TNF IL1B CASP1
27
Nucleotide-binding oligomerization domain (NOD) pathway 74
11.07 NOD1 NLRC4 IL1B CASP1
28
Cellular roles of Anthrax toxin 61
10.86 TNF IL1B CASP1
29
Activation of NLRP3 inflammasome by SARS-CoV-2 74
10.44 CASP1 IL1B
Sources

GO Terms for Legionellosis

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Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi apparatus GO:0005794 10 TLR2 SEC22B RAB8A RAB33B RAB1B RAB1A
2 IPAF inflammasome complex GO:0072557 9.56 NLRC4 CASP1
3 endomembrane system GO:0012505 9.35 SEC22B RAB5A RAB1B RAB1A ARF1
4 phagocytic vesicle membrane GO:0030670 9.32 TLR2 SEC22B RAB8A RAB5A OCRL

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 10.19 TNF TLR5 RAB1A NOD1 NLRC4
2 positive regulation of interleukin-6 production GO:0032755 10.13 IL1B NOD1 TLR2 TNF
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 10.1 TNF NOD1 NLRC4 CASP1
4 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 10.08 TNF NOD1 CASP1
5 defense response to Gram-positive bacterium GO:0050830 10.07 CRP IL1B NOD1 TLR2 TNF
6 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.06 IL1B NOD1 TLR2 TNF
7 lipopolysaccharide-mediated signaling pathway GO:0031663 10.04 TNF TLR2 IL1B
8 positive regulation of interleukin-1 beta production GO:0032731 10.03 TNF NOD1 NLRC4 CASP1
9 positive regulation of inflammatory response GO:0050729 10.02 TNF TLR2 NLRC4 IL1B CASP1
10 protein transport GO:0015031 10 ANK2 ARF1 RAB1A RAB1B RAB33B RAB5A
11 positive regulation of chemokine production GO:0032722 9.99 TNF TLR2 IL1B
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.98 TNF TLR5 IL1B
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 TNF TLR2 NOD1 NLRC4 IL1B CD40LG
14 positive regulation of interleukin-18 production GO:0032741 9.92 TNF TLR2
15 vascular endothelial growth factor production GO:0010573 9.91 TNF IL1B
16 virion assembly GO:0019068 9.91 RAB1B RAB1A
17 positive regulation of fever generation GO:0031622 9.88 TNF IL1B
18 pattern recognition receptor signaling pathway GO:0002221 9.88 NOD1 NLRC4 CASP1
19 sequestering of triglyceride GO:0030730 9.86 IL1B TNF
20 inflammatory response GO:0006954 9.86 CD40LG CRP IL1B NLRC4 NOD1 TLR2
21 positive regulation of toll-like receptor signaling pathway GO:0034123 9.85 TLR5 TLR2
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.81 TNF IL1B
23 positive regulation of glycoprotein metabolic process GO:1903020 9.78 RAB1B RAB1A
24 positive regulation of interleukin-8 production GO:0032757 9.4 TNF TLR5 TLR2 RAB1A NOD1 IL1B

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.86 RAB8A RAB5A RAB33B RAB1B RAB1A NOD1
2 G protein activity GO:0003925 9.8 RAB5A RAB1B RAB1A
3 hydrolase activity GO:0016787 9.76 RAB8A RAB5A RAB1B RAB1A OCRL CASP1
4 GTP binding GO:0005525 9.73 ARF1 RAB1A RAB1B RAB33B RAB5A RAB8A
5 GTPase activity GO:0003924 9.4 RAB8A RAB5A RAB33B RAB1B RAB1A ARF1
Sources

Sources for Legionellosis

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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