MCID: LGN002
MIFTS: 67

Legionellosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Legionellosis

MalaCards integrated aliases for Legionellosis:

Name: Legionellosis 12 77 60 30 6 3 45 15 41 17 74
Legionnaires Disease 60 56
Legionaire Disease, Susceptibility to 13
Legionnaires' Disease 74
Legionella Infection 12
Pontiac Fever 74

Characteristics:

Orphanet epidemiological data:

60
legionellosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (France); Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Legionellosis

CDC : 3 Legionnaires’ (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. Legionella can also cause a milder illness called Pontiac fever. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella. Most people exposed to Legionella do not get sick. However, people 50 years or older, current or former smokers, and people with a weakened immune system or chronic disease are at increased risk.

MalaCards based summary : Legionellosis, also known as legionnaires disease, is related to legionnaires' disease and aspergillosis, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionellosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Clarithromycin and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone, and related phenotypes are fever and fatigue

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

Wikipedia : 77 Legionnaires'' disease, also known as legionellosis, is a form of atypical pneumonia caused by any type... more...

Related Diseases for Legionellosis

Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 legionnaires' disease 32.5 NLRC4 PIK3C2A TLR4 TLR5
2 aspergillosis 30.3 TLR2 TLR4 TNF
3 pertussis 30.1 IL1B TLR4 TNF
4 burns 30.0 IL1B TNF
5 q fever 30.0 IL1B TLR2 TLR4 TNF
6 lyme disease 30.0 IL1B TLR2 TNF
7 pneumonia 29.9 IL1B PIK3C2A TLR2 TLR4 TLR5 TNF
8 colitis 29.9 IL1B TLR4 TNF
9 typhoid fever 29.4 CASP1 IL1B TLR4 TLR5 TNF
10 chlamydia 29.4 CASP1 IL1B TLR2 TLR4 TNF
11 psoriatic arthritis 29.4 IL1B NFKBIA TNF
12 myocardial infarction 29.1 CASP1 IL1B PIK3C2A TLR4 TNF
13 systemic lupus erythematosus 29.0 CR1 IL1B TLR2 TLR4 TLR5 TNF
14 pontiac fever 11.5
15 legionnaire disease 10.3
16 alcoholic gastritis 10.3 CASP1 IL1B
17 fungal keratitis 10.3 TLR2 TLR4
18 acute cervicitis 10.3 TLR2 TLR4
19 periodontitis, chronic 10.3 IL1B TLR2
20 familial cold autoinflammatory syndrome 1 10.2 CASP1 IL1B
21 septic arthritis 10.2 TLR2 TLR4 TLR5
22 macrophage activation syndrome 10.2 NLRC4 TNF
23 exudative glomerulonephritis 10.2 IL1B TNF
24 staphylococcal toxic shock syndrome 10.2 IL1B TNF
25 kashin-beck disease 10.2 IL1B TNF
26 vulvar vestibulitis syndrome 10.2 IL1B TNF
27 cinca syndrome 10.2 CASP1 IL1B NLRC4
28 familial cold autoinflammatory syndrome 10.2 CASP1 IL1B NLRC4
29 trench fever 10.2 TLR2 TLR4 TNF
30 penicilliosis 10.2 TLR2 TLR4 TNF
31 spondylarthropathy 10.2 TLR2 TLR4 TNF
32 glossitis 10.2 IL1B TNF
33 alveolar echinococcosis 10.2 TLR2 TLR4 TNF
34 echinococcosis 10.2 TLR2 TLR4 TNF
35 immune system disease 10.1 ARF1 TLR5 TNF
36 laryngitis 10.1 IL1B TNF
37 cardiogenic shock 10.1 PIK3C2A TNF
38 filariasis 10.1 TLR2 TLR4 TNF
39 chronic recurrent multifocal osteomyelitis 10.1 CASP1 IL1B
40 ornithosis 10.1
41 myocarditis 10.1
42 campylobacteriosis 10.1 IL1B TLR4
43 cutaneous leishmaniasis 10.1 TLR2 TLR4 TNF
44 retinitis pigmentosa 49 10.1 EEF1A2 HBS1L
45 visceral leishmaniasis 10.1 TLR2 TLR4 TNF
46 prosthetic joint infection 10.1 IL1B TLR2 TLR4
47 meningitis 10.1 IL1B TLR2 TNF
48 haemophilus influenzae 10.1 IL1B TLR2 TNF
49 cerebral artery occlusion 10.1 IL1B TNF
50 irak4 deficiency 10.1 MYD88 TLR2 TLR4 TLR5

Graphical network of the top 20 diseases related to Legionellosis:



Diseases related to Legionellosis

Symptoms & Phenotypes for Legionellosis

Human phenotypes related to Legionellosis:

60 33 (show all 42)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
3 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
4 cough 60 33 hallmark (90%) Very frequent (99-80%) HP:0012735
5 pulmonary infiltrates 60 33 hallmark (90%) Very frequent (99-80%) HP:0002113
6 respiratory insufficiency 60 33 frequent (33%) Frequent (79-30%) HP:0002093
7 arrhythmia 60 33 frequent (33%) Frequent (79-30%) HP:0011675
8 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
9 ataxia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001251
10 muscle weakness 60 33 occasional (7.5%) Occasional (29-5%) HP:0001324
11 nausea and vomiting 60 33 occasional (7.5%) Occasional (29-5%) HP:0002017
12 encephalitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002383
13 hypotension 60 33 occasional (7.5%) Occasional (29-5%) HP:0002615
14 hallucinations 60 33 occasional (7.5%) Occasional (29-5%) HP:0000738
15 splenomegaly 60 33 occasional (7.5%) Occasional (29-5%) HP:0001744
16 reduced consciousness/confusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0004372
17 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
18 proteinuria 60 33 occasional (7.5%) Occasional (29-5%) HP:0000093
19 arthralgia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002829
20 hepatitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012115
21 bone marrow hypocellularity 60 33 occasional (7.5%) Occasional (29-5%) HP:0005528
22 abdominal pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0002027
23 peripheral neuropathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0009830
24 abnormality of the pleura 60 33 occasional (7.5%) Occasional (29-5%) HP:0002103
25 jaundice 60 33 occasional (7.5%) Occasional (29-5%) HP:0000952
26 pancreatitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001733
27 anorexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002039
28 migraine 60 33 occasional (7.5%) Occasional (29-5%) HP:0002076
29 hematuria 60 33 occasional (7.5%) Occasional (29-5%) HP:0000790
30 hemoptysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002105
31 lymphopenia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001888
32 hyponatremia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002902
33 diarrhea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002014
34 pericarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001701
35 myocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012819
36 endocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100584
37 recurrent pharyngitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100776
38 cellulitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100658
39 sepsis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100806
40 lymphadenopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0002716
41 restrictive ventilatory defect 60 33 occasional (7.5%) Occasional (29-5%) HP:0002091
42 abnormality of lung morphology 60 Very frequent (99-80%)

UMLS symptoms related to Legionellosis:


fever, pruritus, snoring, coughing

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CASP1 IL1B MYD88 NFKBIA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 IL1B MYD88 NAIP NFKBIA NLRC4

MGI Mouse Phenotypes related to Legionellosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CASP1 EEF1A2 MYD88 NFKBIA NLRC4 PIK3C2A
2 hematopoietic system MP:0005397 10.1 CASP1 EEF1A2 HBS1L IL1B MYD88 NFKBIA
3 growth/size/body region MP:0005378 10.07 EEF1A2 HBS1L IL1B MYD88 NFKBIA PIK3C2A
4 cardiovascular system MP:0005385 10.03 CASP1 IL1B MYD88 PIK3C2A TLR2 TLR4
5 adipose tissue MP:0005375 10 HBS1L MYD88 PIK3C2A TLR2 TLR4 TLR5
6 homeostasis/metabolism MP:0005376 9.96 CASP1 HBS1L IL1B MYD88 NFKBIA PIK3C2A
7 immune system MP:0005387 9.93 CASP1 EEF1A2 HBS1L IL1B MYD88 NFKBIA
8 mortality/aging MP:0010768 9.7 ARF1 CASP1 EEF1A2 IL1B MYD88 NFKBIA
9 neoplasm MP:0002006 9.1 CASP1 IL1B MYD88 TLR2 TLR4 TNF

Drugs & Therapeutics for Legionellosis

Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clarithromycin Approved Phase 4 81103-11-9 84029
2
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 441411 12560
3
Azithromycin Approved Phase 4 83905-01-5 447043 55185
4
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
5
Polyestradiol phosphate Approved Phase 4,Phase 1 28014-46-2
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1 50-28-2 5757
7
Norgestimate Approved, Investigational Phase 4,Phase 1 35189-28-7 6540478
8
Moxifloxacin Approved, Investigational Phase 4,Phase 1 354812-41-2, 151096-09-2 152946
9
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
10
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
11
Piperacillin Approved Phase 4 66258-76-2 43672
12
Ofloxacin Approved Phase 4 82419-36-1 4583
13
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
15
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
16
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
17
Tazobactam Approved Phase 4 89786-04-9 123630
18 Anti-Bacterial Agents Phase 4,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 1
20 Erythromycin Ethylsuccinate Phase 4
21 Cytochrome P-450 Enzyme Inhibitors Phase 4
22 Erythromycin Estolate Phase 4
23 Antitubercular Agents Phase 4,Phase 1
24 Cytochrome P-450 CYP3A Inhibitors Phase 4
25 Erythromycin stearate Phase 4
26 Anti-Infective Agents Phase 4,Phase 1
27 Estradiol 3-benzoate Phase 4,Phase 1
28 Contraceptives, Oral Phase 4,Phase 1
29 Estradiol 17 beta-cypionate Phase 4,Phase 1
30 Contraceptives, Oral, Combined Phase 4,Phase 1
31 Contraceptive Agents Phase 4,Phase 1
32 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 1
33 Topoisomerase Inhibitors Phase 4,Phase 1
34 beta-Lactamase Inhibitors Phase 4
35 Hydrocortisone-17-butyrate Phase 4
36 Hydrocortisone 17-butyrate 21-propionate Phase 4
37 Anti-Infective Agents, Urinary Phase 4
38 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
39 Hydrocortisone hemisuccinate Phase 4
40 Anti-Inflammatory Agents Phase 4
41 Piperacillin, Tazobactam Drug Combination Phase 4
42 Renal Agents Phase 4
43 Clavulanic Acids Phase 4
44 Amoxicillin-Potassium Clavulanate Combination Phase 4
45 Cephalosporins Phase 4
46
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
47
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
48
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
49
Rifampicin Approved Phase 1 13292-46-1 5381226 5458213
50
Kanamycin Approved, Investigational, Vet_approved Phase 1 59-01-8, 8063-07-8 6032

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Recruiting NCT02735707 Phase 4 Hydrocortisone;Ceftriaxone;Moxifloxacin or Levofloxacin;Piperacillin tazobactam;Ceftaroline;Amoxicillin Clavulanate;Macrolide administered for 3 days;Macrolide administered for up to 14 days
3 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
4 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
5 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
6 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
7 Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed NCT01922024
8 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Recruiting NCT03064737 Not Applicable
9 Legionnaires' Effect on Smell Recruiting NCT03321786
10 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
11 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153 Not Applicable

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: legionellosis

Genetic Tests for Legionellosis

Genetic tests related to Legionellosis:

# Genetic test Affiliating Genes
1 Legionellosis 30 TLR5

Anatomical Context for Legionellosis

MalaCards organs/tissues related to Legionellosis:

42
Lung, Testes, Bone, Bone Marrow, Monocytes, Colon, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

20
Respiratory Tract

Publications for Legionellosis

Articles related to Legionellosis:

(show top 50) (show all 1700)
# Title Authors Year
1
DNA-based bioassay of legionella pneumonia pathogen using gold nanostructure: A new platform for diagnosis of legionellosis. ( 30685302 )
2019
2
Preventing legionellosis outbreaks by a quick detection of airborne Legionella pneumophila. ( 30763875 )
2019
3
A Proactive Environmental Approach for Preventing Legionellosis in Infants: Water Sampling and Antibiotic Resistance Monitoring, a 3-Years Survey Program. ( 30857147 )
2019
4
Environmental Surveillance of Legionellosis within an Italian University Hospital-Results of 15 Years of Analysis. ( 30925660 )
2019
5
Lessons Learnt From Exercise Celestial Navigation: The Application of a Geographic Information System to Inform Legionnaires' Disease Control Activity. ( 29716666 )
2019
6
National Surveillance of Legionnaires' Disease, China, 2014-2016. ( 31107214 )
2019
7
Cardiovascular events and de novo AF following Legionnaires disease. ( 30686660 )
2019
8
Association Between Sporadic Legionellosis and River Systems in Connecticut. ( 29211873 )
2018
9
Of Time and the River: How Our Understanding of Legionellosis Has Changed Since 1976. ( 29211906 )
2018
10
Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211. ( 29247056 )
2018
11
Combining Environmental Investigation and a Dual-Analytical Strategy to Isolate the Legionella longbeachae Strain Linked to Two Occupational Cases of Legionellosis. ( 29304227 )
2018
12
Notes from the Field: Legionellosis Outbreak Associated with a Hotel Aquatics Facility - Tennessee, 2017. ( 29346335 )
2018
13
Control and prevention measures for legionellosis in hospitals: A cross-sectional survey in Italy. ( 29864633 )
2018
14
Legionella pneumophila and Other Legionella Species Isolated from Legionellosis Patients in Japan between 2008 and 2016. ( 29980559 )
2018
15
Preventing Healthcare-Associated Legionellosis: Results after 3 Years of Continuous Disinfection of Hot Water with Monochloramine and an Effective Water Safety Plan. ( 30060459 )
2018
16
Legionellosis Associated with Recreational Waters: A Systematic Review of Cases and Outbreaks in Swimming Pools, Spa Pools, and Similar Environments. ( 30061526 )
2018
17
The shift in seasonality of legionellosis in the USA. ( 30099976 )
2018
18
Legionellosis in Poland in 2016 ( 30111084 )
2018
19
Environmental surveillance of Legionella pneumophila in distal water supplies of a hospital for early identification & prevention of hospital-acquired legionellosis. ( 30168494 )
2018
20
Legionnaires' disease at a medical center in southern Taiwan. ( 28094205 )
2018
21
Lessons Learned From Implementing an Incident Command System During a Local Multiagency Response to a Legionnaires' Disease Cluster in Sydney, NSW. ( 28870277 )
2018
22
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. ( 29298342 )
2018
23
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: A case report. ( 29311436 )
2018
24
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
25
Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015. ( 29386076 )
2018
26
Fever of unknown origin due to Legionnaires' disease: A diagnostic challenge. ( 29412169 )
2018
27
Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29432149 )
2018
28
Complete Genome Sequence of Legionella sainthelensi Isolated from a Patient with Legionnaires' Disease. ( 29437115 )
2018
29
Legionnaires' Disease and Use of Water Dispensers With an Ultraviolet Sterilizer. ( 29493477 )
2018
30
Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas. ( 29559643 )
2018
31
The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms. ( 29572569 )
2018
32
Environmental sources of community-acquired legionnaires' disease: A review. ( 29729999 )
2018
33
Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017. ( 29744757 )
2018
34
Rapid Identification of a Cooling Tower-Associated Legionnaires' Disease Outbreak Supported by Polymerase Chain Reaction Testing of Environmental Samples, New York City, 2014-2015. ( 29780175 )
2018
35
Correction for Zahran et al., Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29891661 )
2018
36
A Case Note on Legionnaires' Disease Caused by Serogroup 1, Sequence Type ST496 in Singapore. ( 29911737 )
2018
37
Legionnaires' Disease Outbreak on a Merchant Vessel, Indian Ocean, Australia, 2015. ( 29912714 )
2018
38
Sensitivity and Positive Predictive Value of Death Certificate Data Among Deaths Caused by Legionnaires' Disease in New York City, 2008-2013. ( 30005174 )
2018
39
Timeliness of travel-associated Legionnaires' disease surveillance. ( 30102506 )
2018
40
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: A case report. ( 30122733 )
2018
41
Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181540 )
2018
42
Author Response to Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181566 )
2018
43
Clusters of Healthcare-Associated Legionnaires' Disease in Two Hospitals of Central Greece. ( 30186646 )
2018
44
Two Community Clusters of Legionnaires' Disease Directly Linked to a Biologic Wastewater Treatment Plant, the Netherlands. ( 30226165 )
2018
45
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: a case report. ( 30259881 )
2018
46
Preventing hospital-acquired Legionnaires' disease: A snapshot of clinical practices and water management approaches in US acute-care hospitals. ( 30293535 )
2018
47
Simulation of Legionnaires' disease prospective spatiotemporal cluster detection, Allegheny County, Pennsylvania, USA. ( 30334502 )
2018
48
Legionella and Legionnaires' disease: Time to explore in India. ( 30429383 )
2018
49
Travel-associated Legionnaires' disease: would changing cluster definition lead to the prevention of a larger number of cases? ( 30501676 )
2018
50
A community outbreak of Legionnaires' disease in Geneva, Switzerland, June to September 2017. ( 30552854 )
2018

Variations for Legionellosis

ClinVar genetic disease variations for Legionellosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh38 Chromosome 1, 223111257: 223111257
2 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh37 Chromosome 1, 223284599: 223284599
3 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh38 Chromosome 1, 223111858: 223111858
4 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh37 Chromosome 1, 223285200: 223285200

Expression for Legionellosis

Search GEO for disease gene expression data for Legionellosis.

Pathways for Legionellosis

Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 ARF1 CASP1 CR1 IL1B MYD88 NFKBIA
2
Show member pathways
13.34 IL1B MYD88 TLR2 TLR4 TLR5 TNF
3
Show member pathways
13.19 IL1B MYD88 NFKBIA PIK3C2A TLR2 TLR4
4
Show member pathways
12.95 IL1B MYD88 NFKBIA TLR2 TLR4 TNF
5
Show member pathways
12.79 CASP1 MYD88 NAIP NFKBIA TNF
6
Show member pathways
12.79 CASP1 IL1B MYD88 NAIP NFKBIA NLRC4
7
Show member pathways
12.76 CASP1 IL1B MYD88 NFKBIA TLR4 TNF
8
Show member pathways
12.7 IL1B MYD88 NFKBIA TLR2 TLR4 TLR5
9
Show member pathways
12.59 IL1B NFKBIA TLR2 TLR4 TLR5 TNF
10 12.58 IL1B MYD88 NFKBIA TLR2 TNF
11
Show member pathways
12.57 CASP1 IL1B MYD88 NFKBIA TLR2 TLR4
12
Show member pathways
12.43 MYD88 NFKBIA TLR2 TLR4 TLR5
13
Show member pathways
12.34 IL1B NFKBIA TLR2 TLR5 TNF
14
Show member pathways
12.33 IL1B MYD88 NFKBIA TLR4 TNF
15
Show member pathways
12.3 CASP1 IL1B MYD88 NFKBIA
16
Show member pathways
12.28 MYD88 NFKBIA TLR2 TLR4 TLR5 TNF
17
Show member pathways
12.23 CASP1 IL1B MYD88 NFKBIA TNF
18
Show member pathways
12.22 CASP1 IL1B TLR4 TNF
19 12.22 CR1 IL1B MYD88 TLR2 TLR4 TNF
20
Show member pathways
12.2 IL1B MYD88 TLR2 TLR4 TLR5
21
Show member pathways
12.2 IL1B MYD88 NFKBIA TLR2 TLR5 TNF
22 12.19 TLR2 TLR4 TLR5 TNF
23
Show member pathways
12.14 CR1 IL1B MYD88 NFKBIA TLR2 TLR4
24
Show member pathways
12.07 IL1B TLR2 TLR4 TLR5 TNF
25
Show member pathways
12.06 IL1B TLR2 TLR4 TNF
26
Show member pathways
12.03 IL1B NFKBIA PIK3C2A TLR2 TLR4 TLR5
27
Show member pathways
12.02 IL1B MYD88 NFKBIA TLR2 TLR4 TLR5
28 11.99 IL1B NFKBIA TNF
29 11.96 IL1B TLR4 TNF
30 11.95 IL1B MYD88 NFKBIA TLR4 TNF
31 11.93 IL1B TLR2 TLR4 TNF
32 11.92 IL1B NFKBIA TNF
33 11.89 IL1B TLR2 TLR4 TNF
34 11.86 CR1 IL1B TNF
35 11.85 CR1 TLR2 TLR4 TLR5
36
Show member pathways
11.84 MYD88 NFKBIA TLR4
37 11.79 CASP1 IL1B MYD88 TLR4 TNF
38 11.78 CASP1 IL1B MYD88 NLRC4 TLR4 TLR5
39 11.76 MYD88 NFKBIA TLR4 TNF
40
Show member pathways
11.66 IL1B NFKBIA TNF
41 11.62 MYD88 NFKBIA TLR4 TNF
42 11.55 IL1B TLR2 TLR4 TNF
43 11.42 IL1B MYD88 TNF
44 11.41 CASP1 IL1B NAIP NFKBIA NLRC4
45 11.39 IL1B TLR4 TNF
46 11.22 IL1B MYD88 TLR2
47 11.21 ARF1 CASP1 CR1 EEF1A2 HBS1L IL1B
48 11.17 CASP1 IL1B TNF
49 11.13 MYD88 NFKBIA TLR2
50 11.12 CR1 IL1B MYD88 TLR2 TLR4 TNF

GO Terms for Legionellosis

Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IPAF inflammasome complex GO:0072557 8.62 CASP1 NLRC4

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.98 CR1 MYD88 NAIP NLRC4 TLR2 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 CASP1 IL1B MYD88 TLR4 TNF
3 response to lipopolysaccharide GO:0032496 9.93 IL1B MYD88 NFKBIA TLR2 TLR4
4 cellular response to lipopolysaccharide GO:0071222 9.92 CASP1 IL1B TLR4 TLR5 TNF
5 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
6 cellular response to interferon-gamma GO:0071346 9.88 CASP1 TLR2 TLR4
7 defense response to Gram-positive bacterium GO:0050830 9.88 MYD88 TLR2 TNF
8 positive regulation of JNK cascade GO:0046330 9.88 IL1B MYD88 TLR4 TNF
9 positive regulation of inflammatory response GO:0050729 9.88 NFKBIA TLR2 TLR4 TNF
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.87 CASP1 NLRC4 TNF
11 regulation of inflammatory response GO:0050727 9.85 MYD88 TLR4 TNF
12 apoptotic signaling pathway GO:0097190 9.84 CASP1 TLR4 TNF
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.84 NFKBIA TLR4 TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.83 MYD88 TLR2 TLR4
15 interleukin-1-mediated signaling pathway GO:0070498 9.82 IL1B MYD88 NFKBIA
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL1B TLR2 TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B TLR4 TNF
18 toll-like receptor signaling pathway GO:0002224 9.79 MYD88 TLR2 TLR4
19 positive regulation of chemokine production GO:0032722 9.77 TLR2 TLR4 TNF
20 cellular response to mechanical stimulus GO:0071260 9.77 CASP1 IL1B MYD88 TLR4 TLR5
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL1B TLR4 TLR5 TNF
22 inflammatory response GO:0006954 9.76 IL1B MYD88 NAIP NLRC4 TLR2 TLR4
23 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4 TLR5
24 activation of innate immune response GO:0002218 9.73 NLRC4 TLR4
25 microglial cell activation GO:0001774 9.73 TLR2 TNF
26 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
27 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 IL1B MYD88 NLRC4 TLR2 TLR4 TNF
28 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 MYD88 TLR4
29 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B TNF
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
31 toll-like receptor 4 signaling pathway GO:0034142 9.72 NFKBIA TLR4
32 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B MYD88 TLR2 TLR4 TNF
33 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
34 negative regulation of growth of symbiont in host GO:0044130 9.71 MYD88 TNF
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
36 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR4
37 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.71 MYD88 TLR2 TLR4 TLR5
38 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
39 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 TLR4
40 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
41 negative regulation of lipid storage GO:0010888 9.68 NFKBIA TNF
42 positive regulation of lymphocyte proliferation GO:0050671 9.68 MYD88 TLR4
43 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.68 MYD88 TLR4
44 interleukin-1 beta secretion GO:0050702 9.68 NLRC4 TLR4
45 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
46 positive regulation of neuroinflammatory response GO:0150078 9.66 IL1B TNF
47 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
48 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B MYD88 TNF
49 positive regulation of toll-like receptor signaling pathway GO:0034123 9.63 TLR2 TLR5
50 sequestering of triglyceride GO:0030730 9.63 IL1B TNF

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 CASP1 MYD88 NFKBIA NLRC4 TLR2 TLR4
2 translation elongation factor activity GO:0003746 9.32 EEF1A2 HBS1L
3 Toll-like receptor binding GO:0035325 9.26 MYD88 TLR2
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
5 interleukin-1 receptor binding GO:0005149 8.8 IL1B MYD88 TLR5

Sources for Legionellosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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