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MCID: LGN002
MIFTS: 67

Legionellosis

Categories: Infectious diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Legionellosis

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MalaCards integrated aliases for Legionellosis:

Name: Legionellosis 12 76 59 29 6 3 44 15 40 73
Legionnaires Disease 59 55
Legionaire Disease, Susceptibility to 13
Legionnaires' Disease 73
Legionella Infection 12
Pontiac Fever 73

Characteristics:

Orphanet epidemiological data:

59
legionellosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (France); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 34 33
Orphanet: 59  
Rare infectious diseases


Sources

Summaries for Legionellosis

About this section
CDC : 3 Legionnaires’ (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. Legionella can also cause a milder illness called Pontiac fever. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella. Most people exposed to Legionella do not get sick. However, people 50 years or older, current or former smokers, and people with a weakened immune system or chronic disease are at increased risk.

MalaCards based summary : Legionellosis, also known as legionnaires disease, is related to legionnaires' disease and pneumonia, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionellosis is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Innate Immune System and IL-2 Pathway. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone, and related phenotypes are ataxia and muscle weakness

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in respiratory tract, has material basis in Legionella pneumophila, which is transmitted by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

Wikipedia : 76 Legionnaires'' disease is a form of atypical pneumonia caused by any type of Legionella bacteria. Signs... more...

Sources

Related Diseases for Legionellosis

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Diseases related to Legionellosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 legionnaires' disease 32.2 NLRC4 PIK3C2A TLR4 TLR5
2 pneumonia 30.2 IL1B PIK3C2A TLR2 TLR4 TLR5 TNF
3 aspergillosis 30.1 TLR2 TLR4 TNF
4 pertussis 30.1 IL1B TLR4 TNF
5 q fever 30.0 IL1B TLR2 TLR4 TNF
6 burns 30.0 IL1B TNF
7 colitis 29.9 IL1B TLR4 TNF
8 psoriatic arthritis 29.7 IL1B NFKBIA TNF
9 typhoid fever 29.6 CASP1 IL1B TLR4 TLR5 TNF
10 chlamydia 29.5 CASP1 IL1B TLR2 TLR4 TNF
11 myocardial infarction 29.3 CASP1 IL1B PIK3C2A TLR4 TNF
12 systemic lupus erythematosus 29.2 CR1 IL1B TLR2 TLR4 TLR5 TNF
13 pontiac fever 11.5
14 legionnaire disease 10.3
15 alcoholic gastritis 10.2 CASP1 IL1B
16 exudative glomerulonephritis 10.2 IL1B TNF
17 familial cold autoinflammatory syndrome 1 10.2 CASP1 IL1B
18 staphylococcal toxic shock syndrome 10.2 IL1B TNF
19 kashin-beck disease 10.2 IL1B TNF
20 periodontitis, chronic 10.2 IL1B TLR2
21 rheumatoid lung disease 10.2 IL1B TNF
22 macrophage activation syndrome 10.2 NLRC4 TNF
23 vulvar vestibulitis syndrome 10.2 IL1B TNF
24 glossitis 10.2 IL1B TNF
25 laryngitis 10.1 IL1B TNF
26 cinca syndrome 10.1 CASP1 IL1B NLRC4
27 familial cold autoinflammatory syndrome 10.1 CASP1 IL1B NLRC4
28 fungal keratitis 10.1 TLR2 TLR4
29 chronic recurrent multifocal osteomyelitis 10.1 CASP1 IL1B
30 cardiogenic shock 10.1 PIK3C2A TNF
31 retinitis pigmentosa 49 10.1 EEF1A2 HBS1L
32 opisthorchiasis 10.1 IL1B TNF
33 acute cervicitis 10.1 TLR2 TLR4
34 ornithosis 10.1
35 myocarditis 10.1
36 familial mediterranean fever 10.1 CASP1 IL1B TNF
37 meningitis 10.1 IL1B TLR2 TNF
38 haemophilus influenzae 10.1 IL1B TLR2 TNF
39 congenital cytomegalovirus 10.1 IL1B TLR2 TNF
40 periapical periodontitis 10.1 IL1B TLR2 TNF
41 primary systemic mycosis 10.1 IL1B TLR2 TNF
42 retinitis pigmentosa 60 10.1 IL1B TNF
43 trench fever 10.1 TLR2 TLR4 TNF
44 aphthous stomatitis 10.1 IL1B TLR2 TNF
45 anterior uveitis 10.1 TLR2 TLR4 TNF
46 parasitic protozoa infectious disease 10.1 IL1B TLR2 TNF
47 campylobacteriosis 10.1 IL1B TLR4
48 penicilliosis 10.1 TLR2 TLR4 TNF
49 lyme disease 10.1 IL1B TLR2 TNF
50 spondylarthropathy 10.1 TLR2 TLR4 TNF

Graphical network of the top 20 diseases related to Legionellosis:



Diseases related to Legionellosis
Sources

Symptoms & Phenotypes for Legionellosis

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Human phenotypes related to Legionellosis:

59 32 (show all 42)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001251
2 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
3 nausea and vomiting 59 32 occasional (7.5%) Occasional (29-5%) HP:0002017
4 respiratory insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002093
5 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
6 hypotension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002615
7 hallucinations 59 32 occasional (7.5%) Occasional (29-5%) HP:0000738
8 splenomegaly 59 32 occasional (7.5%) Occasional (29-5%) HP:0001744
9 reduced consciousness/confusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0004372
10 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
11 proteinuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000093
12 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
13 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
14 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
15 arrhythmia 59 32 frequent (33%) Frequent (79-30%) HP:0011675
16 hepatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012115
17 bone marrow hypocellularity 59 32 occasional (7.5%) Occasional (29-5%) HP:0005528
18 abdominal pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0002027
19 peripheral neuropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0009830
20 abnormality of the pleura 59 32 occasional (7.5%) Occasional (29-5%) HP:0002103
21 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
22 pancreatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001733
23 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
24 migraine 59 32 occasional (7.5%) Occasional (29-5%) HP:0002076
25 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
26 hematuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000790
27 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
28 lymphopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001888
29 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
30 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
31 diarrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002014
32 pericarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001701
33 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
34 endocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100584
35 recurrent pharyngitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100776
36 cellulitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100658
37 sepsis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100806
38 cough 59 32 hallmark (90%) Very frequent (99-80%) HP:0012735
39 lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002716
40 pulmonary infiltrates 59 32 hallmark (90%) Very frequent (99-80%) HP:0002113
41 restrictive ventilatory defect 59 32 occasional (7.5%) Occasional (29-5%) HP:0002091
42 abnormality of lung morphology 59 Very frequent (99-80%)

UMLS symptoms related to Legionellosis:


fever, pruritus, snoring, coughing

GenomeRNAi Phenotypes related to Legionellosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.4 CASP1 IL1B MYD88 NFKBIA TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.4 CASP1 IL1B MYD88 NAIP NFKBIA NLRC4

MGI Mouse Phenotypes related to Legionellosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CASP1 EEF1A2 MYD88 NFKBIA NLRC4 PIK3C2A
2 hematopoietic system MP:0005397 10.1 CASP1 EEF1A2 HBS1L IL1B MYD88 NFKBIA
3 growth/size/body region MP:0005378 10.07 EEF1A2 HBS1L IL1B MYD88 NFKBIA PIK3C2A
4 cardiovascular system MP:0005385 10.03 CASP1 IL1B MYD88 PIK3C2A TLR2 TLR4
5 adipose tissue MP:0005375 10 HBS1L MYD88 PIK3C2A TLR2 TLR4 TLR5
6 homeostasis/metabolism MP:0005376 9.96 CASP1 HBS1L IL1B MYD88 NFKBIA PIK3C2A
7 immune system MP:0005387 9.93 CASP1 EEF1A2 HBS1L IL1B MYD88 NFKBIA
8 mortality/aging MP:0010768 9.7 ARF1 CASP1 EEF1A2 IL1B MYD88 NFKBIA
9 neoplasm MP:0002006 9.1 CASP1 IL1B MYD88 TLR2 TLR4 TNF
Sources

Drugs & Therapeutics for Legionellosis

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Drugs for Legionellosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4
Moxifloxacin Approved, Investigational Phase 4,Phase 1 354812-41-2, 151096-09-2 152946
5
Polyestradiol phosphate Approved Phase 4,Phase 1 28014-46-2
6
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
7
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1 50-28-2 5757
8
Norgestimate Approved, Investigational Phase 4,Phase 1 35189-28-7 6540478
9 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 1 979-32-8
10
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
11
Tazobactam Approved Phase 4 89786-04-9 123630
12
Piperacillin Approved Phase 4 66258-76-2 43672
13
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
15
Ofloxacin Approved Phase 4 82419-36-1 4583
16
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
17
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
18 Anti-Bacterial Agents Phase 4,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 1
20 Anti-Infective Agents Phase 4,Phase 1
21 Antitubercular Agents Phase 4,Phase 1
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 Erythromycin stearate Phase 4
24 Cytochrome P-450 CYP3A Inhibitors Phase 4
25 Erythromycin Estolate Phase 4
26 Erythromycin Ethylsuccinate Phase 4
27 Estradiol 3-benzoate Phase 4,Phase 1
28 Contraceptives, Oral Phase 4,Phase 1
29 Topoisomerase Inhibitors Phase 4,Phase 1
30 Estradiol 17 beta-cypionate Phase 4,Phase 1
31 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1
32 Contraceptives, Oral, Combined Phase 4,Phase 1
33 Fluoroquinolones Phase 4,Phase 1
34 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 1
35 Contraceptive Agents Phase 4,Phase 1
36 Penicillanic Acid Phase 4
37 Hydrocortisone-17-butyrate Phase 4
38 Renal Agents Phase 4
39 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
40 Anti-Inflammatory Agents Phase 4
41 Cephalosporins Phase 4
42 Hydrocortisone 17-butyrate 21-propionate Phase 4
43 Clavulanic Acids Phase 4
44 Anti-Infective Agents, Urinary Phase 4
45 Piperacillin, tazobactam drug combination Phase 4
46 Amoxicillin-Potassium Clavulanate Combination Phase 4
47 Cortisol succinate Phase 4
48 beta-Lactamase Inhibitors Phase 4
49
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
50
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Recruiting NCT02735707 Phase 4 Hydrocortisone;Ceftriaxone;Moxifloxacin or Levofloxacin;Piperacillin tazobactam;Ceftaroline;Amoxicillin Clavulanate;Macrolide administered for 3 days;Macrolide administered for up to 14 days
3 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
4 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
5 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
6 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
7 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Recruiting NCT03064737 Not Applicable
8 Legionnaires' Effect on Smell Recruiting NCT03321786
9 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
10 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153 Not Applicable

Search NIH Clinical Center for Legionellosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: legionellosis

Sources

Genetic Tests for Legionellosis

About this section

Genetic tests related to Legionellosis:

# Genetic test Affiliating Genes
1 Legionellosis 29 TLR5
Sources

Anatomical Context for Legionellosis

About this section

MalaCards organs/tissues related to Legionellosis:

41
Lung, Testes, Bone, Bone Marrow, Monocytes, Colon, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Legionellosis:

19
Respiratory Tract
Sources

Publications for Legionellosis

About this section

Articles related to Legionellosis:

(show top 50) (show all 1447)
# Title Authors Year
1
Environmental sources of community-acquired legionnaires' disease: A review. ( 29729999 )
2018
2
Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017. ( 29744757 )
2018
3
Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211. ( 29247056 )
2018
4
Complete Genome Sequence of<i>Legionella sainthelensi</i>Isolated from a Patient with Legionnaires' Disease. ( 29437115 )
2018
5
Fever of unknown origin due to Legionnaires' disease: A diagnostic challenge. ( 29412169 )
2018
6
Legionnaires' Disease and Use of Water Dispensers With an Ultraviolet Sterilizer. ( 29493477 )
2018
7
Characterization of <i>Legionella pneumophila</i> and <i>Legionella</i> species from legionellosis patients in Japan between 2008 and 2016. ( 29980559 )
2018
8
Combining Environmental Investigation and a Dual-Analytical Strategy to Isolate the Legionella longbeachae Strain Linked to Two Occupational Cases of Legionellosis. ( 29304227 )
2018
9
The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms. ( 29572569 )
2018
10
Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29432149 )
2018
11
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. ( 29298342 )
2018
12
A Case Note on Legionnaires' Disease Caused by Serogroup 1, Sequence Type ST496 in Singapore. ( 29911737 )
2018
13
Association Between Sporadic Legionellosis and River Systems in Connecticut. ( 29211873 )
2018
14
Legionnaires' Disease Outbreak on a Merchant Vessel, Indian Ocean, Australia, 2015. ( 29912714 )
2018
15
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
16
Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015. ( 29386076 )
2018
17
Control and prevention measures for legionellosis in hospitals: A cross-sectional survey in Italy. ( 29864633 )
2018
18
Lessons Learnt From Exercise Celestial Navigation: The Application of a Geographic Information System to Inform Legionnaires' Disease Control Activity. ( 29716666 )
2018
19
Of Time and the River: How Our Understanding of Legionellosis Has Changed Since 1976. ( 29211906 )
2018
20
Correction for Zahran et al., Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29891661 )
2018
21
Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas. ( 29559643 )
2018
22
Notes from the Field: Legionellosis Outbreak Associated with a Hotel Aquatics Facility - Tennessee, 2017. ( 29346335 )
2018
23
Legionnaires' disease at a medical center in southern Taiwan. ( 28094205 )
2018
24
Rapid Identification of a Cooling Tower-Associated Legionnaires' Disease Outbreak Supported by Polymerase Chain Reaction Testing of Environmental Samples, New York City, 2014-2015. ( 29780175 )
2018
25
Sensitivity and Positive Predictive Value of Death Certificate Data Among Deaths Caused by Legionnaires' Disease in New York City, 2008-2013. ( 30005174 )
2018
26
Preventing Healthcare-Associated Legionellosis: Results after 3 Years of Continuous Disinfection of Hot Water with Monochloramine and an Effective Water Safety Plan. ( 30060459 )
2018
27
Legionellosis Associated with Recreational Waters: A Systematic Review of Cases and Outbreaks in Swimming Pools, Spa Pools, and Similar Environments. ( 30061526 )
2018
28
The shift in seasonality of legionellosis in the USA. ( 30099976 )
2018
29
Timeliness of travel-associated Legionnaires' disease surveillance. ( 30102506 )
2018
30
Legionellosis in Poland in 2016 ( 30111084 )
2018
31
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: A case report. ( 30122733 )
2018
32
Environmental surveillance of Legionella pneumophila in distal water supplies of a hospital for early identification & prevention of hospital-acquired legionellosis. ( 30168494 )
2018
33
Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181540 )
2018
34
Author Response to Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181566 )
2018
35
Clusters of Healthcare-Associated Legionnaires' Disease in Two Hospitals of Central Greece. ( 30186646 )
2018
36
Two Community Clusters of Legionnaires' Disease Directly Linked to a Biologic Wastewater Treatment Plant, the Netherlands. ( 30226165 )
2018
37
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: a case report. ( 30259881 )
2018
38
Preventing hospital-acquired Legionnaires' disease: A snapshot of clinical practices and water management approaches in US acute-care hospitals. ( 30293535 )
2018
39
Simulation of Legionnaires' disease prospective spatiotemporal cluster detection, Allegheny County, Pennsylvania, USA. ( 30334502 )
2018
40
Legionella and Legionnaires' disease: Time to explore in India. ( 30429383 )
2018
41
Travel-associated Legionnaires' disease: would changing cluster definition lead to the prevention of a larger number of cases? ( 30501676 )
2018
42
A community outbreak of Legionnaires' disease in Geneva, Switzerland, June to September 2017. ( 30552854 )
2018
43
Why Are Legionnaires Disease Diagnoses Becoming More Common in the United States? ( 29641815 )
2018
44
Community-acquired Legionnaires' disease at a medical center in northern Taiwan. ( 28964650 )
2017
45
Legionnaires' disease in transplant recipients: A 15-year retrospective study in a tertiary referral center. ( 28696077 )
2017
46
Legionnaires' Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases. ( 28615983 )
2017
47
Distribution System Operational Deficiencies Coincide with Reported Legionnaires' Disease Clusters in Flint, Michigan. ( 28849909 )
2017
48
Increase in Legionnaires' disease cases associated with travel to Dubai among travellers from the United Kingdom, Sweden and the Netherlands, October 2016 to end August 2017. ( 28935023 )
2017
49
Legionellosis in the occupational setting. ( 27717486 )
2017
50
Legionnaires' Disease (Legionella Infection) ( 28613558 )
2017
Sources

Variations for Legionellosis

About this section

ClinVar genetic disease variations for Legionellosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh38 Chromosome 1, 223111257: 223111257
2 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh37 Chromosome 1, 223284599: 223284599
3 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh38 Chromosome 1, 223111858: 223111858
4 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh37 Chromosome 1, 223285200: 223285200
Sources

Expression for Legionellosis

About this section
Search GEO for disease gene expression data for Legionellosis.
Sources

Pathways for Legionellosis

About this section

Pathways related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14 ARF1 CASP1 CR1 IL1B MYD88 NFKBIA
2
IL-2 Pathway 64
Show member pathways
 13.2 IL1B MYD88 NFKBIA PIK3C2A TLR2 TLR4
3
Human cytomegalovirus infection 37
Show member pathways
 13.05 IL1B MYD88 NFKBIA TLR2 TLR4 TNF
4
Apoptosis Modulation and Signaling 1
Show member pathways
 12.79 CASP1 MYD88 NAIP NFKBIA TNF
5
Influenza A 37
Show member pathways
 12.79 CASP1 IL1B MYD88 NFKBIA TLR2 TLR4
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.77 CASP1 IL1B MYD88 NFKBIA TLR4 TNF
7
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.71 CASP1 IL1B MYD88 NAIP NFKBIA NLRC4
8
NF-KappaB Family Pathway 64
Show member pathways
 12.7 IL1B MYD88 NFKBIA TLR2 TLR4 TLR5
9
Th17 cell differentiation 37
Show member pathways
 12.6 IL1B NFKBIA TLR2 TLR4 TLR5 TNF
10
NF-kappaB Signaling 4
12.58 IL1B MYD88 NFKBIA TLR2 TNF
11
TRAF Pathway 64
Show member pathways
 12.57 CASP1 IL1B MYD88 NFKBIA TLR2 TLR4
12
VEGF Pathway (Qiagen) 22
Show member pathways
 12.43 MYD88 NFKBIA TLR2 TLR4 TLR5
13
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 IL1B NFKBIA TLR2 TLR5 TNF
14
Toll Comparative Pathway 64
Show member pathways
 12.33 IL1B MYD88 NFKBIA TLR4 TNF
15
IL-1 signaling pathway 1
Show member pathways
 12.3 CASP1 IL1B MYD88 NFKBIA
16
Epstein-Barr virus infection 37
12.29 MYD88 NFKBIA TLR2 TNF
17
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.28 MYD88 NFKBIA TLR2 TLR4 TLR5 TNF
18
C-type lectin receptor signaling pathway 37
Show member pathways
 12.23 CASP1 IL1B MYD88 NFKBIA TNF
19
Necroptosis 37
Show member pathways
 12.22 CASP1 IL1B TLR4 TNF
20
Tuberculosis 37
12.22 CR1 IL1B MYD88 TLR2 TLR4 TNF
21
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.2 IL1B MYD88 TLR2 TLR4 TLR5
22
Colorectal Cancer Metastasis 64
12.2 TLR2 TLR4 TLR5 TNF
23
IL-1 Family Signaling Pathways 65
Show member pathways
 12.2 IL1B MYD88 NFKBIA TLR2 TLR5 TNF
24
Toxoplasmosis 37
Show member pathways
 12.14 CR1 IL1B MYD88 NFKBIA TLR2 TLR4
25
Th1 Differentiation Pathway 65
Show member pathways
 12.08 IL1B TLR2 TLR4 TLR5 TNF
26
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.06 IL1B TLR2 TLR4 TNF
27
MAPK Pathway 72
Show member pathways
 12.03 IL1B NFKBIA PIK3C2A TLR2 TLR4 TLR5
28
Bacterial infections in CF airways 22
Show member pathways
 12.02 IL1B MYD88 NFKBIA TLR2 TLR4 TLR5
29
Osteoclast differentiation 37
12 IL1B NFKBIA TNF
30
Spinal Cord Injury 1
11.97 IL1B TLR4 TNF
31
Amoebiasis 37
11.93 IL1B TLR2 TLR4 TNF
32
TNF signaling pathway 37
11.92 IL1B NFKBIA TNF
33
NF-kappa B signaling pathway 37
11.92 IL1B MYD88 NFKBIA TLR4 TNF
34
Rheumatoid arthritis 37
11.89 IL1B TLR2 TLR4 TNF
35
Hematopoietic cell lineage 37
11.87 CR1 IL1B TNF
36
Phagocytosis of Microbes 64
11.86 CR1 TLR2 TLR4 TLR5
37
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.85 MYD88 NFKBIA TLR4
38
Pertussis 37
11.79 CASP1 IL1B MYD88 TLR4 TNF
39
Salmonella infection (KEGG) 37
11.78 CASP1 IL1B MYD88 NLRC4 TLR4 TLR5
40
NF-kB (NFkB) Pathway 67
11.77 MYD88 NFKBIA TLR4 TNF
41
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.67 IL1B NFKBIA TNF
42
Transcription_NF-kB signaling pathway 22
11.62 MYD88 NFKBIA TLR4 TNF
43
MSP-RON Signaling 64
11.56 IL1B TLR2 TLR4 TNF
44
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
11.41 CASP1 IL1B NAIP NFKBIA NLRC4
45
African trypanosomiasis 37
11.4 IL1B MYD88 TNF
46
IL-10 Pathway 64
11.39 IL1B TLR4 TNF
47
IL1 and megakaryocytes in obesity 1
11.23 IL1B MYD88 TLR2
48
Legionellosis 37
11.21 ARF1 CASP1 CR1 EEF1A2 HBS1L IL1B
49
Cellular roles of Anthrax toxin 1
11.17 CASP1 IL1B TNF
50
NTHi-Induced Signaling 64
11.14 MYD88 NFKBIA TLR2
Sources

GO Terms for Legionellosis

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Cellular components related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IPAF inflammasome complex GO:0072557 8.62 CASP1 NLRC4

Biological processes related to Legionellosis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.98 CR1 MYD88 NAIP NLRC4 TLR2 TLR4
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 CASP1 IL1B MYD88 TLR4 TNF
3 response to lipopolysaccharide GO:0032496 9.93 IL1B MYD88 NFKBIA TLR2 TLR4
4 cellular response to lipopolysaccharide GO:0071222 9.92 CASP1 IL1B TLR4 TLR5 TNF
5 activation of MAPK activity GO:0000187 9.89 IL1B TLR4 TNF
6 cellular response to interferon-gamma GO:0071346 9.88 CASP1 TLR2 TLR4
7 defense response to Gram-positive bacterium GO:0050830 9.88 MYD88 TLR2 TNF
8 positive regulation of JNK cascade GO:0046330 9.88 IL1B MYD88 TLR4 TNF
9 positive regulation of inflammatory response GO:0050729 9.88 NFKBIA TLR2 TLR4 TNF
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.87 CASP1 NLRC4 TNF
11 regulation of inflammatory response GO:0050727 9.85 MYD88 TLR4 TNF
12 apoptotic signaling pathway GO:0097190 9.84 CASP1 TLR4 TNF
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.84 NFKBIA TLR4 TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.83 MYD88 TLR2 TLR4
15 interleukin-1-mediated signaling pathway GO:0070498 9.82 IL1B MYD88 NFKBIA
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 IL1B TLR2 TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B TLR4 TNF
18 toll-like receptor signaling pathway GO:0002224 9.79 MYD88 TLR2 TLR4
19 positive regulation of chemokine production GO:0032722 9.77 TLR2 TLR4 TNF
20 cellular response to mechanical stimulus GO:0071260 9.77 CASP1 IL1B MYD88 TLR4 TLR5
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL1B TLR4 TLR5 TNF
22 inflammatory response GO:0006954 9.76 IL1B MYD88 NAIP NLRC4 TLR2 TLR4
23 regulation of cytokine secretion GO:0050707 9.74 TLR2 TLR4 TLR5
24 activation of innate immune response GO:0002218 9.73 NLRC4 TLR4
25 protein import into nucleus, translocation GO:0000060 9.73 NFKBIA TNF
26 microglial cell activation GO:0001774 9.73 TLR2 TNF
27 negative regulation of lipid catabolic process GO:0050995 9.73 IL1B TNF
28 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 IL1B MYD88 NLRC4 TLR2 TLR4 TNF
29 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.72 MYD88 TLR4
30 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B TNF
31 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
32 toll-like receptor 4 signaling pathway GO:0034142 9.72 NFKBIA TLR4
33 positive regulation of interleukin-6 production GO:0032755 9.72 IL1B MYD88 TLR2 TLR4 TNF
34 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
35 negative regulation of growth of symbiont in host GO:0044130 9.71 MYD88 TNF
36 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
37 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR4
38 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.71 MYD88 TLR2 TLR4 TLR5
39 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
40 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 TLR4
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
42 negative regulation of lipid storage GO:0010888 9.68 NFKBIA TNF
43 positive regulation of lymphocyte proliferation GO:0050671 9.68 MYD88 TLR4
44 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.68 MYD88 TLR4
45 interleukin-1 beta secretion GO:0050702 9.68 NLRC4 TLR4
46 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
47 positive regulation of neuroinflammatory response GO:0150078 9.66 IL1B TNF
48 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
49 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B MYD88 TNF
50 chronic inflammatory response to antigenic stimulus GO:0002439 9.64 IL1B TNF

Molecular functions related to Legionellosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 CASP1 MYD88 NFKBIA NLRC4 TLR2 TLR4
2 translation elongation factor activity GO:0003746 9.32 EEF1A2 HBS1L
3 Toll-like receptor binding GO:0035325 9.26 MYD88 TLR2
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
5 interleukin-1 receptor binding GO:0005149 8.8 IL1B MYD88 TLR5
Sources

Sources for Legionellosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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