MCID: LGN006
MIFTS: 52

Legionnaire Disease

Categories: Genetic diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Legionnaire Disease

MalaCards integrated aliases for Legionnaire Disease:

Name: Legionnaire Disease 57
Legionnaires' Disease 12 74 20 42 3 44 15 17 71
Legionnaires Disease 20 54 32
Legionnaire Disease, Susceptibility to 57 6
Legionella 12 15
Legionaire Disease, Susceptibility to 13
Infection by Legionella Pneumophilia 12
Legionnaire's Disease 12
Legionella Pneumonia 12
Legionellosis 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10457
OMIM® 57 608556
ICD9CM 34 482.84
MeSH 44 D007877
NCIt 50 C128339
SNOMED-CT 67 195889001
ICD10 32 A48.1
UMLS 71 C0023241

Summaries for Legionnaire Disease

GARD : 20 Legionnaires' disease is a severe type of pneumonia caused by the bacteria Legionella. The species Legionella pneumophila causes most cases, but other species of Legionella can also cause the disease. It is named Legionnaires' disease because it was first discovered after a pneumonia outbreak among people who attended an American Legion Convention in Philadelphia, Pennsylvania in 1976. Most people exposed to Legionella do not become sick with Legionnaires' disease. People who do become sick usually develop symptoms within 2 to 10 days after exposure, but it may take longer. The first symptoms may include headache, chills, muscle pains, and a fever that can be 104?F (40?C) or higher. Additional symptoms usually develop 1 to 2 days after the first symptoms and may include coughing, shortness of breath, chest pain, diarrhea, nausea and vomiting, and confusion. While Legionnaires' disease mainly affects the lungs, it sometimes causes infections in other parts of the body, such as the heart or within body wounds. A person can become infected from Legionella when they inhale mist or water droplets that contain the bacteria. Sources of exposure may include showers, faucets, whirlpools, grocery store misters, and water droplets passing through ventilation systems in large buildings (such as hotels, office buildings, and hospitals). People who are more susceptible to developing Legionnaires' disease after an exposure include adults over age 50, current or former smokers, and people who have a weakened immune system or a chronic disease. Generally, neither the bacteria nor Legionnaires' disease is spread directly from person to person. While large exposures can result in outbreaks, the disease usually occurs in single, isolated cases. Legionnaires' disease may be suspected by symptoms. Pneumonia can be confirmed by a chest X-ray. Legionnaires' disease is diagnosed when one of the species of Legionella is found to be the cause of the pneumonia by testing a urine sample (urine culture) or a sample of saliva and mucus that is coughed up (sputum culture). Without treatment, the disease can be fatal. People with the disease who are otherwise healthy usually recover with antibiotics, although they may need to be cared for in a hospital. About 1 in 10 people with Legionnaires' disease will not survive due to complications such as respiratory failure, kidney failure, or septic shock. Of note, Legionella can also cause a milder illness called Pontiac fever, which causes flu-like symptoms, but does not cause pneumonia. Pontiac fever typically goes away without specific treatment.

MalaCards based summary : Legionnaire Disease, also known as legionnaires' disease, is related to legionellosis and ornithosis, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionnaire Disease is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Metabolism of proteins and Vesicle-mediated transport. The drugs Azithromycin and Erythromycin have been mentioned in the context of this disorder. Affiliated tissues include monocytes, bone marrow and heart, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

OMIM® : 57 Legionnaire disease (LD) is a type of pneumonia caused by Legionella pneumophila, a flagellated gram-negative bacterium found primarily in warm water environments. The disease and the bacterium were discovered following an outbreak traced to a 1976 American Legion convention in Philadelphia. A number of risk factors for acquiring LD have been identified, including age, smoking, chronic lung disease, cancer, and immunosuppression (summary by Hawn et al., 2003). (608556) (Updated 05-Mar-2021)

MedlinePlus : 42 Legionnaires' disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from water that contains the bacteria. The mist may come from hot tubs, showers, or air-conditioning units for large buildings. The bacteria don't spread from person to person. Symptoms of Legionnaires' disease include high fever, chills, a cough, and sometimes muscle aches and headaches. Other types of pneumonia have similar symptoms. You will probably need a chest x-ray to diagnose the pneumonia. Lab tests can detect the specific bacteria that cause Legionnaires' disease. Most people exposed to the bacteria do not become sick. You are more likely to get sick if you Are older than 50 Smoke Have a chronic lung disease Have a weak immune system Legionnaires' disease is serious and can be life-threatening. However, most people recover with antibiotic treatment. Centers for Disease Control and Prevention

CDC : 3 Legionnaires' (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella.

Wikipedia : 74 Legionnaires' disease is a form of atypical pneumonia caused by any species of Legionella bacteria,... more...

Related Diseases for Legionnaire Disease

Diseases related to Legionnaire Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 453)
# Related Disease Score Top Affiliating Genes
1 legionellosis 32.4 TLR5 SEC22B RAB1B NLRC4 CASP1 ARF1
2 ornithosis 30.9 PIK3C2A CRP
3 gas gangrene 30.2 SERPINA3 PIK3C2A CRP
4 typhoid fever 30.2 TLR5 CRP CASP1
5 aspiration pneumonia 30.2 SERPINA3 PIK3C2A CRP
6 acute pancreatitis 30.1 SERPINA3 CRP CASP1
7 bacterial infectious disease 30.1 TLR5 SERPINA3 CRP CASP1
8 granulomatous disease, chronic, autosomal recessive, 5 10.9
9 acute kidney failure 10.6
10 pontiac fever 10.6
11 kidney disease 10.5
12 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.5
13 disease by infectious agent 10.5
14 respiratory failure 10.5
15 bronchopneumonia 10.4
16 orbital plasma cell granuloma 10.4 PIK3C2A CRP
17 chronic orbital inflammation 10.4 PIK3C2A CRP
18 diarrhea 10.4
19 pyomyositis 10.4 PIK3C2A CRP
20 bacterial pneumonia 10.4
21 xanthogranulomatous pyelonephritis 10.4 SERPINA3 CRP
22 basidiobolomycosis 10.3 PIK3C2A CRP
23 aspiration pneumonitis 10.3 SERPINA3 CRP
24 marginal corneal ulcer 10.3 CRP CASP1
25 adult respiratory distress syndrome 10.3
26 lymphopenia 10.3
27 enterocolitis 10.3 NLRC4 CRP
28 chlamydia pneumonia 10.3
29 endocarditis 10.3
30 renal infectious disease 10.3 NLRC4 CRP CASP1
31 physical urticaria 10.3 SERPINA3 CRP
32 glossopharyngeal nerve disease 10.3 CRP CANX
33 pyelitis 10.3 TLR5 SERPINA3 CRP
34 salmonellosis 10.3 TLR5 NLRC4 CASP1
35 macrophage activation syndrome 10.3 NLRC4 CRP
36 muckle-wells syndrome 10.3 NLRC4 CRP CASP1
37 atypical depressive disorder 10.3 SERPINA3 CRP
38 extrinsic cardiomyopathy 10.3 SERPINA3 PIK3C2A CRP
39 splenic infarction 10.3 SERPINA3 CRP
40 chlamydia 10.3
41 glomerulonephritis 10.3
42 bronchitis 10.3
43 hypotrichosis 3 10.2 RAB35 RAB1B
44 pertussis 10.2
45 cytokine deficiency 10.2
46 pallister-hall-like syndrome 10.2
47 hypophosphatemia 10.2
48 acute kidney tubular necrosis 10.2
49 cataract 8, multiple types 10.2 RAB7A RAB5A ARF1
50 heart conduction disease 10.2 SERPINA3 PIK3C2A CRP ANK2

Graphical network of the top 20 diseases related to Legionnaire Disease:



Diseases related to Legionnaire Disease

Symptoms & Phenotypes for Legionnaire Disease

Clinical features from OMIM®:

608556 (Updated 05-Mar-2021)

UMLS symptoms related to Legionnaire Disease:


fever, pruritus, snoring, coughing

GenomeRNAi Phenotypes related to Legionnaire Disease according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.6 PIK3C2A
2 Decreased viability GR00055-A-2 9.6 PIK3C2A
3 Decreased viability GR00055-A-3 9.6 PIK3C2A
4 Decreased viability GR00221-A-1 9.6 PIK3C2A
5 Decreased viability GR00221-A-2 9.6 PIK3C2A
6 Decreased viability GR00221-A-4 9.6 PIK3C2A
7 Decreased viability GR00240-S-1 9.6 PIK3C2A
8 Decreased viability GR00249-S 9.6 ANKLE1 CASP1 PIK3C2A SERPINA3
9 Decreased viability GR00342-S-1 9.6 PIK3C2A
10 Decreased viability GR00342-S-2 9.6 PIK3C2A
11 Decreased viability GR00342-S-3 9.6 PIK3C2A
12 Decreased viability GR00381-A-1 9.6 RAB1B
13 Decreased viability GR00386-A-1 9.6 ARF1 CANX CASP1
14 Decreased viability GR00402-S-2 9.6 TBC1D5

Drugs & Therapeutics for Legionnaire Disease

Drugs for Legionnaire Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
3
Clarithromycin Approved Phase 4 81103-11-9 84029
4 Erythromycin Estolate Phase 4
5 Erythromycin stearate Phase 4
6 Erythromycin Ethylsuccinate Phase 4
7
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
8
Moxifloxacin Approved, Investigational Phase 1 151096-09-2, 354812-41-2 152946
9
Pyrazinamide Approved, Investigational Phase 1 98-96-4 1046
10
Kanamycin Approved, Investigational, Vet_approved Phase 1 59-01-8, 8063-07-8 6032
11
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
12
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
13
Rifampicin Approved Phase 1 13292-46-1 5458213 5381226
14
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
15 Antitubercular Agents Phase 1
16 Vitamin B3 Phase 1
17 Catalase Phase 1
18 Antimetabolites Phase 1
19 Lipid Regulating Agents Phase 1
20 Hypolipidemic Agents Phase 1
21 Nicotinic Acids Phase 1
22 Fluoroquinolones Phase 1
23 Norgestimate, ethinyl estradiol drug combination Phase 1
24 Anti-Infective Agents
25 Anti-Bacterial Agents
26 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Comparison of Azithromycin or Clarithromycin in 3drugs Protocol of H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Pharmacokinetics of Standard First and Second Line Anti-TB Drugs in the Lung and Lesions of Subjects Elected for Resection Surgery Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
3 Zithromac Iv Special Investigation For Legionella Infection. Completed NCT01784770 Azithromycin IV
4 Molecular Epidemiology of Legionellosis in Grenoble Region Completed NCT02884700
5 The Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia - A Hospital Based Study in Malaysia Completed NCT03200275
6 Procalcitonin Antibiotic Consensus Trial (ProACT) Completed NCT02130986
7 Prevalence of Legionella Infections, Bacterial Etiology in Pneumonia Among Patients Admitted to Hospital,- and Risk Factors/Characteristics for These Patients.(Translated From Norwegian) Completed NCT00467701
8 Legionella Pneumonia's Effect on Olfactory Function Recruiting NCT03321786
9 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Recruiting NCT03064737
10 Nosocomial and Community Acquired Legionella Pneumophila Pneumonia, a Retrospective Case Series Recruiting NCT04106037
11 Impact of a Strategy Combining the Rapid Polymerase Chain Reaction Platform FilmArray® and the Intervention of an Antimicrobial Stewardship Team in Hospital-acquired Pneumonia in Non-mechanically Ventilated Patients: a Randomized Controlled Trial. Recruiting NCT04153682
12 Impact of Comprehensive Molecular Tests on Antimicrobial Stewardship in Community-acquired Pneumonia: an Open, Controlled and Randomized Clinical Trial Recruiting NCT04158492
13 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153

Search NIH Clinical Center for Legionnaire Disease

Inferred drug relations via UMLS 71 / NDF-RT 51 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: legionnaires' disease

Genetic Tests for Legionnaire Disease

Anatomical Context for Legionnaire Disease

MalaCards organs/tissues related to Legionnaire Disease:

40
Monocytes, Bone Marrow, Heart, Brain, Neutrophil, Kidney, Liver

Publications for Legionnaire Disease

Articles related to Legionnaire Disease:

(show top 50) (show all 2977)
# Title Authors PMID Year
1
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. 6 61 54 57
14623910 2003
2
Source attribution of community-acquired cases of Legionnaires' disease-results from the German LeTriWa study; Berlin, 2016-2019. 42 61
33237924 2020
3
Impaired TLR5 functionality is associated with survival in melioidosis. 6
23447684 2013
4
A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. 6
16027372 2005
5
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1. 42
33469029 2021
6
How Molecular Typing Can Support Legionella Environmental Surveillance in Hot Water Distribution Systems: A Hospital Experience. 42
33233464 2020
7
Legionella community-acquired pneumonia (CAP) presenting with spontaneous bilateral pneumothoraces. 61 54
18482636 2008
8
Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. 54 61
15747241 2005
9
An outbreak investigation of Legionella non-pneumophila Legionnaires' disease in Sweden, April to August 2018: Gardening and use of commercial bagged soil associated with infections. 61
33602385 2021
10
Outbreak of Legionnaires' Disease in the Northern Portuguese Coast During the COVID-19 Pandemic. 61
33600747 2021
11
The Tail-specific protease is important for Legionella pneumophila to survive thermal stress in water and inside amoeba. 61
33608288 2021
12
The Role of Lipids in Legionella-Host Interaction. 61
33540788 2021
13
Legionnaires' disease in the time of COVID-19. 61
33407911 2021
14
A Methodology for Classifying Root Causes of Outbreaks of Legionnaires' Disease: Deficiencies in Environmental Control and Water Management. 61
33401429 2021
15
Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation. 61
33491325 2021
16
A Bioinformatic Pipeline for Improved Genome Analysis and Clustering of Isolates during Outbreaks of Legionnaires' Disease. 61
33239371 2021
17
Health after Legionnaires' disease: A description of hospitalizations up to 5 years after Legionella pneumonia. 61
33428684 2021
18
Economic Burden of Legionnaires' Disease, United States, 2014. 61
33350911 2021
19
Legionellosis in Japan: A Self-inflicted Wound? 61
32727982 2021
20
Confirming the Presence of Legionella pneumophila in Your Water System: A Review of Current Legionella Testing Methods. 61
33484265 2021
21
Quorum sensing controls persistence, resuscitation, and virulence of Legionella subpopulations in biofilms. 61
32951019 2021
22
The impact of pipeline changes and temperature increase in a hospital historically colonised with Legionella. 61
33479467 2021
23
Evidence for multiple cases of recurrent Legionella infection: a Danish national surveillance study. 61
33504567 2021
24
Healthcare-Associated Legionella Disease: A Multi-Year Assessment of Exposure Settings in a National Healthcare System in the United States. 61
33525457 2021
25
The mysterious illness that drove them to their knees - Ah, that Legionnaires' disease - A historical reflection of the work in Legionnaires' disease in New Zealand (1978 to mid-1990s) and the 'One Health' paradigm. 61
33117867 2020
26
European Surveillance of Legionnaires' Disease. 61
33284133 2020
27
Travel-associated cases of Legionnaires' disease in the United States, 2015-2016. 61
33279632 2020
28
Legionella pneumophila in Patients with Pneumonia at a Referral Hospital, New Delhi, India, 2015-2020. 61
33319733 2020
29
Legionnaires' Disease in Pediatric Patients, Control Measures and 5-Year Follow-up. 61
32472821 2020
30
Excess Pneumonia Mortality During a 2014-2015 Legionnaires' Disease Outbreak in Genesee County, Michigan. 61
33003151 2020
31
Selection and Characterization of an RNA-Cleaving DNAzyme Activated by Legionella pneumophila. 61
33188548 2020
32
The small regulatory RNA Lpr10 regulates the expression of RpoS in Legionella pneumophila. 61
33191583 2020
33
Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection. 61
33185526 2020
34
Unravelling the importance of the eukaryotic and bacterial communities and their relationship with Legionella spp. ecology in cooling towers: a complex network. 61
33183356 2020
35
Decoding Cell-Cell Communications in Alveolar during Infection: Metabolic Control. 61
33181075 2020
36
Legionnaires' Disease on the Rise in Switzerland: A Denominator-Based Analysis of National Diagnostic Data, 2007-2016. 61
33050023 2020
37
Healthcare-Associated Legionnaires' Disease, Europe, 2008-2017. 61
32946366 2020
38
Enhancement of Culture of Legionella longbeachae from Respiratory Samples by Use of Immunomagnetic Separation and Antimicrobial Decontamination. 61
32817229 2020
39
Characterization of Legionella pneumophila Populations by Multilocus Variable Number of Tandem Repeats (MLVA) Genotyping from Drinking Water and Biofilm in Hospitals from Different Regions of the West Bank. 61
33105606 2020
40
Case report: fatal pneumonia caused by new sequence type Legionella pneumophilia serogroup 1. 61
33120803 2020
41
Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection. 61
33075184 2020
42
Evolution and function of bacterial RCC1 repeat effectors. 61
32720355 2020
43
Comparison of Legionella K-set® and BinaxNOW® Legionella for diagnosing Legionnaires' disease on concentrated urine samples. 61
32303927 2020
44
Invasive pulmonary aspergillosis in an ICU patient with Legionnaires' disease: A diagnostic challenge. 61
32418638 2020
45
Legionnaires Disease Presenting as Diarrhea: A Case Report. 61
33110729 2020
46
Structural analysis of the Legionella pneumophila Dot/Icm type IV secretion system core complex. 61
32876045 2020
47
Chlorine Disinfection of Legionella spp., L. pneumophila, and Acanthamoeba under Warm Water Premise Plumbing Conditions. 61
32971988 2020
48
Interactive Effects of Copper Pipe, Stagnation, Corrosion Control, and Disinfectant Residual Influenced Reduction of Legionella pneumophila during Simulations of the Flint Water Crisis. 61
32899686 2020
49
Evaluation of Legionella spp. Colonization in Residential Buildings Having Solar Thermal System for Hot Water Production. 61
32993154 2020
50
Green waste compost as potential reservoirs of Legionella in the Netherlands. 61
32470567 2020

Variations for Legionnaire Disease

ClinVar genetic disease variations for Legionnaire Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TLR5 NM_003268.6(TLR5):c.1174C>T (p.Arg392Ter) SNV risk factor 6658 rs5744168 1:223285200-223285200 1:223111858-223111858
2 TLR5 NM_003268.6(TLR5):c.1775A>G (p.Asn592Ser) SNV risk factor 6659 rs2072493 1:223284599-223284599 1:223111257-223111257

Expression for Legionnaire Disease

Search GEO for disease gene expression data for Legionnaire Disease.

Pathways for Legionnaire Disease

Pathways related to Legionnaire Disease according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 SEC22B RAB8A RAB7A RAB5A RAB35 RAB1B
2
Show member pathways
13.06 SEC22B RAB8A RAB7A RAB5A RAB35 RAB1B
3
Show member pathways
12.75 SEC22B RAB8A RAB7A RAB5A RAB1B
4
Show member pathways
12.51 TLR5 RAB7A RAB5A PIK3C2A NLRC4 CASP1
5 12.34 RAB8A RAB7A RAB5A RAB35
6
Show member pathways
12.25 RAB8A RAB7A RAB5A ARF1
7 12.24 VPS29 RAB8A RAB7A RAB5A RAB35 ARF1
8 12.2 TLR5 NLRC4 CASP1 ARF1
9 12.12 RAB8A RAB7A RAB5A RAB35 RAB1B
10
Show member pathways
12.06 RAB5A PIK3C2A OCRL ARF1
11 11.94 SEC22B RAB7A RAB5A CANX
12 11.73 RAB7A CANX ARF1
13 11.51 RAB8A RAB7A RAB5A RAB35 RAB1B
14 11.38 RAB8A RAB7A RAB5A RAB35
15 11.17 RAB8A RAB7A RAB5A RAB35 RAB1B
16 10.86 TLR5 SEC22B RAB1B NLRC4 CASP1 ARF1

GO Terms for Legionnaire Disease

Cellular components related to Legionnaire Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.36 VPS29 TLR5 TBC1D5 SEC22B RAB8A RAB7A
2 cytosol GO:0005829 10.25 VPS29 TBC1D5 RAB8A RAB7A RAB5A RAB35
3 extracellular exosome GO:0070062 10.13 SERPINA3 RAB8A RAB7A RAB5A RAB35 RAB1B
4 Golgi apparatus GO:0005794 10.07 TBC1D5 SEC22B RAB8A RAB1B PIK3C2A OCRL
5 cytoplasmic vesicle GO:0031410 9.91 TBC1D5 RAB8A RAB7A RAB5A RAB35 PIK3C2A
6 early endosome GO:0005769 9.86 VPS29 RAB5A OCRL ANK2
7 phagocytic vesicle GO:0045335 9.69 RAB8A RAB7A RAB5A
8 clathrin-coated vesicle GO:0030136 9.67 RAB35 PIK3C2A OCRL
9 endosome membrane GO:0010008 9.63 VPS29 TBC1D5 RAB7A RAB5A RAB35 OCRL
10 melanosome GO:0042470 9.62 SEC22B RAB5A RAB35 CANX
11 endosome GO:0005768 9.56 VPS29 TBC1D5 RAB8A RAB7A RAB5A RAB35
12 COPI-coated vesicle GO:0030137 9.55 SEC22B ARF1
13 anchored component of synaptic vesicle membrane GO:0098993 9.54 RAB5A RAB35
14 IPAF inflammasome complex GO:0072557 9.46 NLRC4 CASP1
15 retromer complex GO:0030904 9.43 VPS29 TBC1D5 RAB7A
16 phagocytic vesicle membrane GO:0030670 9.02 SEC22B RAB8A RAB7A RAB5A OCRL

Biological processes related to Legionnaire Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 endocytosis GO:0006897 9.67 RAB7A RAB5A PIK3C2A ANK2
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.63 RAB7A CANX ARF1
3 retrograde transport, endosome to Golgi GO:0042147 9.58 VPS29 TBC1D5 RAB7A
4 autophagy GO:0006914 9.56 TBC1D5 RAB8A RAB7A RAB1B
5 intracellular protein transport GO:0006886 9.55 VPS29 TBC1D5 RAB5A RAB1B ARF1
6 regulation of autophagy GO:0010506 9.5 VPS29 RAB8A CASP1
7 pyroptosis GO:0070269 9.49 NLRC4 CASP1
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.48 RAB8A RAB5A
9 regulation of autophagosome assembly GO:2000785 9.43 RAB5A RAB1B
10 protein transport GO:0015031 9.32 VPS29 TBC1D5 SEC22B RAB8A RAB7A RAB5A
11 phosphatidylinositol biosynthetic process GO:0006661 9.26 RAB5A PIK3C2A OCRL ARF1

Molecular functions related to Legionnaire Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.92 RAB8A RAB7A RAB5A RAB35 RAB1B PIK3C2A
2 GTP binding GO:0005525 9.63 RAB8A RAB7A RAB5A RAB35 RAB1B ARF1
3 GTPase activity GO:0003924 9.43 RAB8A RAB7A RAB5A RAB35 RAB1B ARF1
4 retromer complex binding GO:1905394 9.26 TBC1D5 RAB7A
5 GDP binding GO:0019003 9.02 RAB8A RAB7A RAB5A RAB35 ARF1

Sources for Legionnaire Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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