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MCID: LGN006
MIFTS: 34

Legionnaire Disease

Categories: Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Legionnaire Disease

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MalaCards integrated aliases for Legionnaire Disease:

Name: Legionnaire Disease 57
Legionnaire Disease, Susceptibility to 57
Legionnaires' Disease 73

Classifications:

MalaCards categories:
Global: Genetic diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 608556
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Summaries for Legionnaire Disease

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OMIM : 57 Legionnaire disease (LD) is a type of pneumonia caused by Legionella pneumophila, a flagellated gram-negative bacterium found primarily in warm water environments. The disease and the bacterium were discovered following an outbreak traced to a 1976 American Legion convention in Philadelphia. A number of risk factors for acquiring LD have been identified, including age, smoking, chronic lung disease, cancer, and immunosuppression (summary by Hawn et al., 2003). (608556)

MalaCards based summary : Legionnaire Disease, also known as legionnaire disease, susceptibility to, is related to legionnaires' disease and legionellosis, and has symptoms including coughing, fever and pruritus. An important gene associated with Legionnaire Disease is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways is Development Slit-Robo signaling. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon.

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Related Diseases for Legionnaire Disease

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Diseases related to Legionnaire Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 legionnaires' disease 12.7
2 legionellosis 12.0
3 pontiac fever 10.7
4 pneumonia 10.3
5 glomerulonephritis 10.0
6 influenza 10.0
7 rheumatoid arthritis 9.9
8 arthritis 9.9
9 swine influenza 9.9
10 q fever 9.9
11 plague 9.9
12 myocarditis 9.9
13 systemic lupus erythematosus 9.7
14 aging 9.7
15 myocardial infarction 9.7
16 acute myocardial infarction 9.7
17 alopecia 9.7
18 burns 9.7
19 leukemia 9.7
20 liver cirrhosis 9.7
21 hypophosphatemia 9.7
22 lymphoma 9.7
23 thrombosis 9.7
24 respiratory failure 9.7
25 disseminated intravascular coagulation 9.7
26 hemopericardium 9.7
27 pericardial effusion 9.7
28 neurogenic bladder 9.7
29 crescentic glomerulonephritis 9.7
30 typhoid fever 9.7
31 pericarditis 9.7
32 cholecystitis 9.7
33 tularemia 9.7
34 sick building syndrome 9.7
35 acalculous cholecystitis 9.7
36 severe acute respiratory syndrome 9.7
37 rapidly progressive glomerulonephritis 9.7
38 proliferative glomerulonephritis 9.7
39 mesangial proliferative glomerulonephritis 9.7
40 pancreatitis 9.7
41 mediastinitis 9.7
42 lupus erythematosus 9.7
43 psoriasis 9.7
44 amebiasis 9.7
45 fasciitis 9.7
46 necrotizing fasciitis 9.7
47 alopecia areata 9.7
48 cold agglutinin disease 9.7
49 ovarian lymphoma 9.0 KRT18 USH2A

Graphical network of the top 20 diseases related to Legionnaire Disease:



Diseases related to Legionnaire Disease
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Symptoms & Phenotypes for Legionnaire Disease

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Clinical features from OMIM:

608556

UMLS symptoms related to Legionnaire Disease:


coughing, fever, pruritus, snoring
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Drugs & Therapeutics for Legionnaire Disease

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Drugs for Legionnaire Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4 Anti-Bacterial Agents Phase 4,Phase 1
5 Antibiotics, Antitubercular Phase 4,Phase 1
6 Anti-Infective Agents Phase 4,Phase 1
7 Antitubercular Agents Phase 4,Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Erythromycin Estolate Phase 4
11 Erythromycin Ethylsuccinate Phase 4
12 Erythromycin stearate Phase 4
13
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
14 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
15
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
16
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
17
Kanamycin Approved, Investigational, Vet_approved Phase 1 8063-07-8, 59-01-8 6032
18
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
19
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
20
Polyestradiol phosphate Approved Phase 1 28014-46-2
21
Pyrazinamide Approved, Investigational Phase 1 98-96-4 1046
22
Rifampicin Approved Phase 1 13292-46-1 5458213 5381226
23
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
24
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
25
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
26 Antimetabolites Phase 1
27 Catalase Phase 1
28 Contraceptive Agents Phase 1
29 Contraceptives, Oral Phase 1
30 Contraceptives, Oral, Combined Phase 1
31 Cytochrome P-450 CYP3A Inducers Phase 1
32 Estradiol 17 beta-cypionate Phase 1
33 Estradiol 3-benzoate Phase 1
34 Fluoroquinolones Phase 1
35 Hypolipidemic Agents Phase 1
36 Lipid Regulating Agents Phase 1
37 Nicotinic Acids Phase 1
38 Norgestimate, ethinyl estradiol drug combination Phase 1
39 Nucleic Acid Synthesis Inhibitors Phase 1
40 Topoisomerase Inhibitors Phase 1
41 Vitamin B3 Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
3 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
4 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
5 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
6 Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed NCT01922024
7 Legionnaires' Effect on Smell Recruiting NCT03321786
8 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
9 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Not yet recruiting NCT03064737 Not Applicable
10 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153 Not Applicable

Search NIH Clinical Center for Legionnaire Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Legionnaire Disease

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Anatomical Context for Legionnaire Disease

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MalaCards organs/tissues related to Legionnaire Disease:

41
Lung, Testes, Colon, Bone Marrow, Bone, Liver, Heart
Sources

Publications for Legionnaire Disease

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Articles related to Legionnaire Disease:

(show top 50) (show all 581)
# Title Authors Year
1
Environmental sources of community-acquired legionnaires' disease: A review. ( 29729999 )
2018
2
Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017. ( 29744757 )
2018
3
Complete Genome Sequence of<i>Legionella sainthelensi</i>Isolated from a Patient with Legionnaires' Disease. ( 29437115 )
2018
4
Fever of unknown origin due to Legionnaires' disease: A diagnostic challenge. ( 29412169 )
2018
5
Legionnaires' Disease and Use of Water Dispensers With an Ultraviolet Sterilizer. ( 29493477 )
2018
6
The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms. ( 29572569 )
2018
7
Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29432149 )
2018
8
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. ( 29298342 )
2018
9
A Case Note on Legionnaires' Disease Caused by Serogroup 1, Sequence Type ST496 in Singapore. ( 29911737 )
2018
10
Legionnaires' Disease Outbreak on a Merchant Vessel, Indian Ocean, Australia, 2015. ( 29912714 )
2018
11
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
12
Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015. ( 29386076 )
2018
13
Lessons Learnt From Exercise Celestial Navigation: The Application of a Geographic Information System to Inform Legionnaires' Disease Control Activity. ( 29716666 )
2018
14
Correction for Zahran et al., Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29891661 )
2018
15
Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas. ( 29559643 )
2018
16
Rapid Identification of a Cooling Tower-Associated Legionnaires' Disease Outbreak Supported by Polymerase Chain Reaction Testing of Environmental Samples, New York City, 2014-2015. ( 29780175 )
2018
17
Community-acquired Legionnaires' disease at a medical center in northern Taiwan. ( 28964650 )
2017
18
Legionnaires' disease in transplant recipients: A 15-year retrospective study in a tertiary referral center. ( 28696077 )
2017
19
Legionnaires' Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases. ( 28615983 )
2017
20
Distribution System Operational Deficiencies Coincide with Reported Legionnaires' Disease Clusters in Flint, Michigan. ( 28849909 )
2017
21
Increase in Legionnaires' disease cases associated with travel to Dubai among travellers from the United Kingdom, Sweden and the Netherlands, October 2016 to end August 2017. ( 28935023 )
2017
22
Legionnaires' Disease (Legionella Infection) ( 28613558 )
2017
23
Short-term effects of atmospheric pressure, temperature, and rainfall on notification rate of community-acquired Legionnaires' disease in four European countries - CORRIGENDUM. ( 29032771 )
2017
24
Lessons Learned From Implementing an Incident Command System During a Local Multiagency Response to a Legionnaires' Disease Cluster in Sydney, NSW. ( 28870277 )
2017
25
Healthcare-associated Legionnaires' disease: Limitations of surveillance definitions and importance of epidemiologic investigation. ( 29344101 )
2017
26
Diagnostic testing for Legionnaires' disease. ( 28851372 )
2017
27
Early Radiographic and Tomographic Manifestations of Legionnaires' Disease. ( 28479105 )
2017
28
Vital Signs: Health Care-Associated Legionnaires' Disease Surveillance Data from 20 States and a Large Metropolitan Area - United States, 2015. ( 28594788 )
2017
29
Legionnaires' Disease As An Occupational Risk Related To Decontamination Work After The Fukushima Nuclear Disaster: A Case Report. ( 29311436 )
2017
30
Accuracy of diagnostic tests for Legionnaires' disease: a systematic review. ( 28463665 )
2017
31
Legionnaires' Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015. ( 29047425 )
2017
32
Vital Signs: Health Care-Associated Legionnaires' Disease Surveillance Data From 20 States and a Large Metropolitan Area-United States, 2015. ( 28724206 )
2017
33
Complete Genome Sequence of a Legionella longbeachae Serogroup 1 Strain Isolated from a Patient with Legionnaires' Disease. ( 28619815 )
2017
34
Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease. ( 28622979 )
2017
35
Weather-Dependent Risk for Legionnaires' Disease, United States. ( 29048279 )
2017
36
Legionnaires' disease from a dental unit. Chicken-and-egg or a different source entirely? ( 28412175 )
2017
37
Community-acquired Legionnaires' Disease in a Newly Constructed Apartment Building. ( 28768406 )
2017
38
Authors' response: Legionnaires' disease following the Christchurch earthquakes. ( 28934775 )
2017
39
Risk Factors for Legionella longbeachae Legionnaires' Disease, New Zealand. ( 28628460 )
2017
40
Legionnaires' Disease Outbreaks and Cooling Towers, New York City, New York, USA. ( 29049017 )
2017
41
Legionnaires' Disease Complicated with Rhabdomyolysis and Acute Kidney Injury in an AIDS Patient. ( 29109879 )
2017
42
Legionnaires' disease in Europe, 2011 to 2015. ( 28703097 )
2017
43
Notes from the Field: Two Cases of Legionnaires' Disease in Newborns After Water Births - Arizona, 2016. ( 28594785 )
2017
44
Tigecycline as a Second-Line Agent for Legionnaires' Disease in Severely Ill Patients. ( 29026871 )
2017
45
Vital Signs: Deficiencies in Environmental Control Identified in Outbreaks of Legionnaires' Disease-North America, 2000-2014. ( 28497871 )
2016
46
Work participation in Q-fever patients and patients with Legionnaires' disease: A 12-month cohort study. ( 25724468 )
2015
47
Comparative analysis of virulence traits between a Legionella feeleii strain implicated in Pontiac fever and a strain that caused Legionnaires' disease. ( 26386398 )
2015
48
Characterization of the extent of a large outbreak of Legionnaires' disease by serological assays. ( 25887275 )
2015
49
Imipenem therapy for Legionnaires' disease. ( 25443312 )
2015
50
The Importance of Clinical Surveillance in Detecting Legionnaires' Disease Outbreaks: A Large Outbreak in a Hospital With a Legionella Disinfection System-Pennsylvania, 2011-2012. ( 25722201 )
2015
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Variations for Legionnaire Disease

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ClinVar genetic disease variations for Legionnaire Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh37 Chromosome 1, 223285200: 223285200
2 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh38 Chromosome 1, 223111858: 223111858
3 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh37 Chromosome 1, 223284599: 223284599
4 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh38 Chromosome 1, 223111257: 223111257
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Expression for Legionnaire Disease

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Search GEO for disease gene expression data for Legionnaire Disease.
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Pathways for Legionnaire Disease

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Pathways related to Legionnaire Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development Slit-Robo signaling 22
Show member pathways
 11.11 KRT18 TLR5
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GO Terms for Legionnaire Disease

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Sources for Legionnaire Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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