MCID: LGN006
MIFTS: 59

Legionnaire Disease

Categories: Genetic diseases, Immune diseases, Infectious diseases, Muscle diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Legionnaire Disease

MalaCards integrated aliases for Legionnaire Disease:

Name: Legionnaire Disease 57
Legionnaires' Disease 11 19 75 41 2 43 14 16 71
Legionnaires Disease 19 58 53 31 33
Legionnaire Disease, Susceptibility to 57 28 5
Legionella Pneumonia 11 33
Legionella 11 14
Legionaire Disease, Susceptibility to 12
Infection by Legionella Pneumophilia 11
Legionnaires Pneumonia 33
Legionnaire's Disease 11
Legionellosis 19

Characteristics:


Prevelance:

Legionnaires Disease: 1-9/100000 (Europe, France, Austria, Belgium, Czech Republic, Denmark, Germany, Italy, Latvia, Luxembourg, Malta, Netherlands, Portugal, Slovenia, Spain, Sweden, New Zealand) 1-9/1000000 (Croatia, Cyprus, Estonia, Finland, Greece, Hungary, Iceland, Ireland, Lithuania, Norway, Slovakia, United Kingdom) <1/1000000 (Poland, Romania) 58

Age Of Onset:

Legionnaires Disease: All ages 58

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Legionnaire Disease

GARD: 19 Legionnaires' disease is a severe type of pneumonia caused by the bacteria Legionella. The species Legionella pneumophila causes most cases, but other species of Legionella can also cause the disease. It is named Legionnaires' disease because it was first discovered after a pneumonia outbreak among people who attended an American Legion Convention in Philadelphia, Pennsylvania in 1976. Most people exposed to Legionella do not become sick with Legionnaires' disease. People who do become sick usually develop symptoms within 2 to 10 days after exposure, but it may take longer. The first symptoms may include headache, chills, muscle pains, and a fever that can be 104°F (40°C) or higher. Additional symptoms usually develop 1 to 2 days after the first symptoms and may include coughing, shortness of breath, chest pain, diarrhea, nausea and vomiting, and confusion. While Legionnaires' disease mainly affects the lungs, it sometimes causes infections in other parts of the body, such as the heart or within body wounds. A person can become infected from Legionella when they inhale mist or water droplets that contain the bacteria. Sources of exposure may include showers, faucets, whirlpools, grocery store misters, and water droplets passing through ventilation systems in large buildings (such as hotels, office buildings, and hospitals). People who are more susceptible to developing Legionnaires' disease after an exposure include adults over age 50, current or former smokers, and people who have a weakened immune system or a chronic disease. Generally, neither the bacteria nor Legionnaires' disease is spread directly from person to person. While large exposures can result in outbreaks, the disease usually occurs in single, isolated cases. Legionnaires' disease may be suspected by symptoms. Pneumonia can be confirmed by a chest X-ray. Legionnaires' disease is diagnosed when one of the species of Legionella is found to be the cause of the pneumonia by testing a urine sample (urine culture) or a sample of saliva and mucus that is coughed up (sputum culture).

MalaCards based summary: Legionnaire Disease, also known as legionnaires' disease, is related to pontiac fever and ornithosis, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionnaire Disease is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Metabolism of proteins and Vesicle-mediated transport. The drugs Azithromycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and heart, and related phenotypes are fatigue and fever

MedlinePlus: 41 Legionnaires' disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from water that contains the bacteria. The mist may come from hot tubs, showers, or air-conditioning units for large buildings. The bacteria don't spread from person to person. Symptoms of Legionnaires' disease include high fever, chills, a cough, and sometimes muscle aches and headaches. Other types of pneumonia have similar symptoms. You will probably need a chest x-ray to diagnose the pneumonia. Lab tests can detect the specific bacteria that cause Legionnaires' disease. Most people exposed to the bacteria do not become sick. You are more likely to get sick if you: Are older than 50 Smoke Have a chronic lung disease Have a weak immune system Legionnaires' disease is serious and can be life-threatening. However, most people recover with antibiotic treatment. Centers for Disease Control and Prevention

OMIM®: 57 Legionnaire disease (LD) is a type of pneumonia caused by Legionella pneumophila, a flagellated gram-negative bacterium found primarily in warm water environments. The disease and the bacterium were discovered following an outbreak traced to a 1976 American Legion convention in Philadelphia. A number of risk factors for acquiring LD have been identified, including age, smoking, chronic lung disease, cancer, and immunosuppression (summary by Hawn et al., 2003). (608556) (Updated 08-Dec-2022)

CDC: 2 Legionnaires' (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella.

Disease Ontology: 11 A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

Orphanet: 58 Legionellosis or Legionnaires' disease (LD) is a bacterial lung infection characterized by a potentially fatal pneumonia.

Wikipedia: 75 Legionnaires' disease is a form of atypical pneumonia caused by any species of Legionella bacteria,... more...

Related Diseases for Legionnaire Disease

Diseases related to Legionnaire Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 600)
# Related Disease Score Top Affiliating Genes
1 pontiac fever 31.2 SEC22B RAB1B ARSD ANK2
2 ornithosis 31.1 PIK3C2A CRP
3 critical illness polyneuropathy 30.4 PIK3C2A CRP
4 toxoplasmosis 30.4 TLR5 PIK3C2A CASP1
5 legionellosis 30.3 TLR5 TBC1D5 SEC22B RAB8A RAB7B RAB7A
6 acute interstitial pneumonia 30.3 NLRC4 CRP
7 adult-onset still's disease 30.2 NLRC4 CRP CASP1
8 cryptogenic organizing pneumonia 30.2 NLRC4 CRP
9 typhoid fever 30.2 TLR5 CRP CASP1
10 lowe oculocerebrorenal syndrome 30.2 RAB8A RAB5A RAB35 OCRL
11 parkinson disease, late-onset 29.6 TBC1D5 RAB8A RAB7B RAB7A RAB5A RAB35
12 house allergic alveolitis 11.0
13 granulomatous disease, chronic, autosomal recessive, 5 10.9
14 acute kidney failure 10.6
15 respiratory failure 10.6
16 kidney disease 10.5
17 adult respiratory distress syndrome 10.4
18 bronchopneumonia 10.4
19 bacterial pneumonia 10.4
20 pyomyositis 10.4 PIK3C2A CRP
21 iron metabolism disease 10.4
22 hemopneumothorax 10.4 PIK3C2A CRP
23 diarrhea 10.4
24 pleural lipoma 10.4 PIK3C2A CRP
25 ankylosing spondylitis 1 10.4 TLR5 CRP
26 inflammatory and toxic neuropathy 10.3 PIK3C2A CRP
27 lymphopenia 10.3
28 acute anterolateral myocardial infarction 10.3 PIK3C2A CRP
29 endocarditis 10.3
30 gastric dilatation 10.3 CRP ARSD
31 enterocolitis 10.3 NLRC4 CRP
32 macrophage activation syndrome 10.3 NLRC4 CRP
33 periodic fever, familial, autosomal dominant 10.3 NLRC4 CRP CASP1
34 salmonellosis 10.3 TLR5 NLRC4 CASP1
35 compartment syndrome 10.3 PIK3C2A CRP
36 bronchitis 10.3
37 cytokine deficiency 10.3
38 klebsiella infection 10.3
39 pallister-hall-like syndrome 10.3
40 chlamydia 10.3
41 glomerulonephritis 10.3
42 neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux 10.3 RAB7B RAB7A
43 pertussis 10.2
44 primary bacterial infectious disease 10.2 TLR5 NLRC4 CRP CASP1
45 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.2
46 bacteremia 2 10.2
47 hypophosphatemia 10.2
48 acute kidney tubular necrosis 10.2
49 hairy cell leukemia 10.2
50 spinocerebellar ataxia, autosomal recessive 15 10.2 RAB7B RAB7A

Graphical network of the top 20 diseases related to Legionnaire Disease:



Diseases related to Legionnaire Disease

Symptoms & Phenotypes for Legionnaire Disease

Human phenotypes related to Legionnaire Disease:

58 30 (show all 44)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0012378
2 fever 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001945
3 myalgia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0003326
4 cough 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0012735
5 pulmonary infiltrates 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002113
6 respiratory insufficiency 58 30 Frequent (33%) Frequent (79-30%)
HP:0002093
7 arrhythmia 58 30 Frequent (33%) Frequent (79-30%)
HP:0011675
8 chest pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0100749
9 nausea and vomiting 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002017
10 ataxia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001251
11 hypotension 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002615
12 muscle weakness 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001324
13 splenomegaly 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001744
14 hallucinations 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000738
15 reduced consciousness/confusion 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0004372
16 proteinuria 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000093
17 renal insufficiency 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000083
18 hepatitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012115
19 hemoptysis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002105
20 jaundice 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000952
21 hematuria 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000790
22 abdominal pain 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002027
23 anorexia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002039
24 arthralgia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002829
25 lymphopenia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001888
26 hyponatremia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002902
27 cellulitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100658
28 peripheral neuropathy 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0009830
29 pericarditis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001701
30 migraine 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002076
31 myocarditis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012819
32 endocarditis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100584
33 recurrent pharyngitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100776
34 sepsis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100806
35 bone marrow hypocellularity 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005528
36 diarrhea 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002014
37 lymphadenopathy 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002716
38 pancreatitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001733
39 restrictive ventilatory defect 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002091
40 infectious encephalitis 30 Occasional (7.5%) HP:0002383
41 abnormal pleura morphology 30 Occasional (7.5%) HP:0002103
42 encephalitis 58 Occasional (29-5%)
43 abnormality of the pleura 58 Occasional (29-5%)
44 abnormal lung morphology 58 Very frequent (99-80%)

Clinical features from OMIM®:

608556 (Updated 08-Dec-2022)

UMLS symptoms related to Legionnaire Disease:


fever; pruritus; snoring; coughing

GenomeRNAi Phenotypes related to Legionnaire Disease according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 ANK2 ANKLE1 ARF1 ARSD CASP1 CRP
2 no effect GR00402-S-2 10.2 ANK2 ANKLE1 ARF1 ARSD CASP1 CRP

MGI Mouse Phenotypes related to Legionnaire Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.44 ANK2 ANKLE1 ARF1 CASP1 NLRC4 OCRL

Drugs & Therapeutics for Legionnaire Disease

Drugs for Legionnaire Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved 83905-01-5 447043
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nosocomial and Community Acquired Legionella Pneumophila Pneumonia, a Retrospective Case Series Completed NCT04106037
2 Zithromac Iv Special Investigation For Legionella Infection. Completed NCT01784770 Azithromycin IV
3 Molecular Epidemiology of Legionellosis in Grenoble Region Completed NCT02884700
4 The Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia - A Hospital Based Study in Malaysia Completed NCT03200275
5 Prevalence of Legionella Infections, Bacterial Etiology in Pneumonia Among Patients Admitted to Hospital,- and Risk Factors/Characteristics for These Patients.(Translated From Norwegian) Completed NCT00467701
6 Legionella Pneumonia's Effect on Olfactory Function Recruiting NCT03321786
7 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Recruiting NCT03064737
8 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153

Search NIH Clinical Center for Legionnaire Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


ERYTHROMYCIN PWDR

Cochrane evidence based reviews: legionnaires' disease

Genetic Tests for Legionnaire Disease

Genetic tests related to Legionnaire Disease:

# Genetic test Affiliating Genes
1 Legionnaire Disease, Susceptibility to 28 TLR5

Anatomical Context for Legionnaire Disease

Organs/tissues related to Legionnaire Disease:

MalaCards : Lung, Bone Marrow, Heart, Bone, Monocytes, Neutrophil, Myeloid

Publications for Legionnaire Disease

Articles related to Legionnaire Disease:

(show top 50) (show all 11003)
# Title Authors PMID Year
1
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. 53 62 57 5
14623910 2003
2
A tail-specific protease is required for Legionella pneumophila intracellular multiplication. 62 41
36194898 2022
3
Epidemiological analysis of Legionnaires' disease in Scotland: a genomic study. 62 41
36240833 2022
4
Environmental Investigation during Legionellosis Outbreak, Montérégie, Quebec, Canada, 2021. 62 41
36286248 2022
5
Impaired TLR5 functionality is associated with survival in melioidosis. 5
23447684 2013
6
A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. 5
16027372 2005
7
Legionella community-acquired pneumonia (CAP) presenting with spontaneous bilateral pneumothoraces. 53 62
18482636 2008
8
Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. 53 62
15747241 2005
9
Microbiological quality of roof tank water in an urban village in southeastern China. 62
36375901 2023
10
Systematic active environmental surveillance successfully identified and controlled the Legionella contamination in the hospital. 62
36162645 2023
11
Temporal trends in legionellosis national notification data and the effect of COVID-19, Switzerland, 2000-2020. 62
35508422 2023
12
Effect of the COVID-19 pandemic and state of emergency declarations on the relative incidence of legionellosis and invasive pneumococcal disease in Japan. 62
36116719 2023
13
Analysis and interpretation of hot springs water, biofilms, and sediment bacterial community profiling and their metabolic potential in the area of Taiwan geothermal ecosystem. 62
36181827 2023
14
The impact of deleting the mitfa gene in zebrafish on the intestinal microbiota community. 62
36075325 2022
15
An algorithm for PCT-guided antimicrobial therapy: a consensus statement by Japanese experts. 62
36453810 2022
16
Microbiological findings and prescribing trends in SARS- CoV-2 positive patients in two United Kingdom Hospitals. 62
36091659 2022
17
Ubiquitin and Legionella: From bench to bedside. 62
35177348 2022
18
TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes. 62
35030980 2022
19
Legionella pneumonia in Argentina: A disease cluster to worry about. 62
36420519 2022
20
Antimicrobial effects of automobile screen washes against Legionella pneumophila. 62
36000381 2022
21
SARS-CoV-2 and Legionella pneumophila coinfection. 62
36464477 2022
22
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones. 62
36411449 2022
23
SARS-CoV-2 and Legionella pneumophila coinfection. 62
34580551 2022
24
Can legionellosis be considered an occupational risk in the healthcare sector? A systematic review and meta-analysis. 62
36463752 2022
25
Aetiology of severe community acquired pneumonia in adults identified by combined detection methods: a multi-centre prospective study in China. 62
35081880 2022
26
Arginine ADP-Ribosylation: Chemical Synthesis of Post-Translationally Modified Ubiquitin Proteins. 62
36318515 2022
27
VpdC is a ubiquitin-activated phospholipase effector that regulates Legionella vacuole expansion during infection. 62
36413498 2022
28
Effects of temperature and light exposure on the decay characteristics of fecal indicators, norovirus, and Legionella in mesocosms simulating subarctic river water. 62
36423850 2022
29
Molecular screening and characterization of Legionella pneumophila associated free-living amoebae in domestic and hospital water systems. 62
36270142 2022
30
Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection. 62
36427489 2022
31
[Influencing factors of Legionella reproduction in secondary water supply operation and management]. 62
36372752 2022
32
Legionellosis risk-an overview of Legionella spp. habitats in Europe. 62
36161570 2022
33
5' Untranslated mRNA Regions Allow Bypass of Host Cell Translation Inhibition by Legionella pneumophila. 62
36321832 2022
34
Legionnaires' Disease Causing Severe Rhabdomyolysis and Acute Renal Failure: A Case Report. 62
36427031 2022
35
Meteorological conditions and Legionnaires' disease sporadic cases-a systematic review. 62
35964674 2022
36
Validation of MICA Legionella for Enumeration of Legionella pneumophila in sanitary waters and cooling tower waters: AOAC Performance Tested MethodSM #032201. 62
36413047 2022
37
Legionella pneumophila PPIase Mip Interacts with the Bacterial Proteins SspB, Lpc2061, and FlaA and Promotes Flagellation. 62
36314784 2022
38
Legionella pneumonia as a rising public health threat in Argentina: Is it the time to worry? 62
36345419 2022
39
The Effect Citrox BCL on Legionella pneumophila Mechanisms of Biofilm Formation, Oxidative Stress and Virulence. 62
36358558 2022
40
Efficacy of empiric macrolides versus fluoroquinolones in community-acquired pneumonia associated with atypical bacteria: A meta-analysis. 62
35905552 2022
41
Triclosan Promotes Conjugative Transfer of Antibiotic Resistance Genes to Opportunistic Pathogens in Environmental Microbiome. 62
36251935 2022
42
Prepandemic viral community-acquired pneumonia: Diagnostic sensitivity and specificity of nasopharyngeal swabs and performance of clinical severity scores. 62
36396153 2022
43
Comparison of the disinfection efficacy between ferrate(VI) and chlorine in secondary effluent. 62
35908691 2022
44
Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones. 62
36400772 2022
45
Serostatus and Epidemiological Characteristics for Atypical Pneumonia Causative Bacteria among Healthy Individuals in Medina, Saudi Arabia, a Retrospective Study. 62
36421640 2022
46
Metagenomics reveals the response of antibiotic resistance genes to elevated temperature in the Yellow River. 62
36410491 2022
47
Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA. 62
36364779 2022
48
Using CFD simulations to investigate the shear stress in hydrodynamic cavitation reactors coupled with experimental validation using colony count measurements. 62
36302786 2022
49
Structure of V-ATPase from citrus fruit. 62
36041457 2022
50
Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA. 62
36007613 2022

Variations for Legionnaire Disease

ClinVar genetic disease variations for Legionnaire Disease:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TLR5 NM_003268.6(TLR5):c.1174C>T (p.Arg392Ter) SNV Risk Factor
6658 rs5744168 GRCh37: 1:223285200-223285200
GRCh38: 1:223111858-223111858
2 TLR5 NM_003268.6(TLR5):c.1775A>G (p.Asn592Ser) SNV Risk Factor
6659 rs2072493 GRCh37: 1:223284599-223284599
GRCh38: 1:223111257-223111257

Expression for Legionnaire Disease

Search GEO for disease gene expression data for Legionnaire Disease.

Pathways for Legionnaire Disease

Pathways related to Legionnaire Disease according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 SEC22B RAB8A RAB7B RAB7A RAB5A RAB35
2
Show member pathways
12.88 SEC22B RAB8A RAB7B RAB7A RAB5A RAB35
3
Show member pathways
12.84 SEC22B RAB7A RAB5A RAB33B RAB1B RAB1A
4
Show member pathways
12.8 SEC22B RAB1B RAB1A ARF1 ANK2
5
Show member pathways
12.65 RAB1A RAB1B RAB33B RAB5A RAB7A RAB8A
6 12.32 RAB1A RAB35 RAB5A RAB7A RAB8A
7
Show member pathways
12.22 RAB8A RAB7A RAB5A ARF1
8
Show member pathways
12.21 RAB8A RAB7A RAB5A RAB35 RAB1B RAB1A
9
Show member pathways
12.17 RAB8A RAB7B RAB7A RAB5A RAB35 RAB33B
10
Show member pathways
12.15 RAB5A PIK3C2A OCRL ARF1
11
Show member pathways
11.69 SEC22B RAB1B RAB1A
12 11.04 RAB8A RAB7B RAB7A RAB5A RAB35 RAB33B
13 10.52 RAB35 OCRL

GO Terms for Legionnaire Disease

Cellular components related to Legionnaire Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016021 10.51 TLR5 SEC22B ARSD ANKLE1
2 membrane GO:0016020 10.51 TLR5 TBC1D5 SEC22B RAB8A RAB7B RAB7A
3 lysosome GO:0005764 10.24 RAB7B RAB7A OCRL ARSD ANK2
4 Golgi apparatus GO:0005794 10.19 ARF1 OCRL PIK3C2A RAB1A RAB1B RAB33B
5 endosome membrane GO:0010008 10.15 TBC1D5 RAB7A RAB5A RAB35 OCRL
6 melanosome GO:0042470 10.06 RAB1A RAB35 RAB5A SEC22B
7 phagocytic vesicle GO:0045335 9.97 RAB8A RAB7B RAB7A RAB5A
8 cytoplasmic vesicle GO:0031410 9.92 TBC1D5 RAB8A RAB7B RAB7A RAB5A RAB35
9 clathrin-coated vesicle GO:0030136 9.91 RAB35 PIK3C2A OCRL
10 inflammasome complex GO:0061702 9.83 NLRC4 CASP1
11 endomembrane system GO:0012505 9.8 ARF1 RAB1A RAB1B RAB5A SEC22B
12 IPAF inflammasome complex GO:0072557 9.78 NLRC4 CASP1
13 phagocytic vesicle membrane GO:0030670 9.73 SEC22B RAB8A RAB7B RAB7A RAB5A OCRL
14 endosome GO:0005768 9.44 TBC1D5 RAB8A RAB7B RAB7A RAB5A RAB35
15 obsolete anchored component of synaptic vesicle membrane GO:0098993 9.33 RAB7A RAB5A RAB35

Biological processes related to Legionnaire Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytosis GO:0006897 10.02 RAB7A RAB5A RAB1A PIK3C2A ANK2
2 autophagosome assembly GO:0000045 9.76 RAB1A RAB1B RAB33B RAB7A
3 regulation of autophagosome assembly GO:2000785 9.73 RAB5A RAB1B
4 icosanoid biosynthetic process GO:0046456 9.71 NLRC4 CASP1
5 virion assembly GO:0019068 9.67 RAB1B RAB1A
6 autophagy GO:0006914 9.61 TBC1D5 RAB8A RAB7A RAB33B RAB1B RAB1A
7 protein transport GO:0015031 9.6 TBC1D5 SEC22B RAB8A RAB7B RAB7A RAB5A
8 positive regulation of glycoprotein metabolic process GO:1903020 9.56 RAB1B RAB1A

Molecular functions related to Legionnaire Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GDP binding GO:0019003 9.97 RAB8A RAB7A RAB5A RAB35
2 hydrolase activity GO:0016787 9.97 RAB8A RAB7A RAB5A RAB1B RAB1A OCRL
3 GTP binding GO:0005525 9.91 ARF1 RAB1A RAB1B RAB33B RAB35 RAB5A
4 nucleotide binding GO:0000166 9.9 ARF1 NLRC4 PIK3C2A RAB1A RAB1B RAB33B
5 G protein activity GO:0003925 9.86 RAB7A RAB5A RAB1B RAB1A
6 retromer complex binding GO:1905394 9.71 TBC1D5 RAB7A
7 GTPase activity GO:0003924 9.58 RAB8A RAB7B RAB7A RAB5A RAB35 RAB33B

Sources for Legionnaire Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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