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MCID: LGN006
MIFTS: 34

Legionnaire Disease

Categories: Genetic diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Legionnaire Disease

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MalaCards integrated aliases for Legionnaire Disease:

Name: Legionnaire Disease 57
Legionnaire Disease, Susceptibility to 57
Legionnaires' Disease 73

Classifications:

MalaCards categories:
Global: Genetic diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 608556
UMLS 73 C0023241
Sources

Summaries for Legionnaire Disease

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OMIM : 57 Legionnaire disease (LD) is a type of pneumonia caused by Legionella pneumophila, a flagellated gram-negative bacterium found primarily in warm water environments. The disease and the bacterium were discovered following an outbreak traced to a 1976 American Legion convention in Philadelphia. A number of risk factors for acquiring LD have been identified, including age, smoking, chronic lung disease, cancer, and immunosuppression (summary by Hawn et al., 2003). (608556)

MalaCards based summary : Legionnaire Disease, also known as legionnaire disease, susceptibility to, is related to legionnaires' disease and legionellosis, and has symptoms including fever, pruritus and snoring. An important gene associated with Legionnaire Disease is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways is Development Slit-Robo signaling. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone.

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Related Diseases for Legionnaire Disease

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Diseases related to Legionnaire Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 legionnaires' disease 12.8
2 legionellosis 12.4
3 pontiac fever 10.8
4 pneumonia 10.6
5 arthritis 10.2
6 influenza 10.2
7 glomerulonephritis 10.1
8 ornithosis 10.1
9 myocarditis 10.1
10 rheumatoid arthritis 10.0
11 leukemia 10.0
12 swine influenza 10.0
13 q fever 10.0
14 pancreatitis 10.0
15 neuropathy 10.0
16 systemic lupus erythematosus 10.0
17 thrombosis 10.0
18 myoglobinuria 10.0
19 interstitial nephritis 10.0
20 hemopericardium 10.0
21 pericardial effusion 10.0
22 neurogenic bladder 10.0
23 mycoplasma pneumoniae pneumonia 10.0
24 pneumothorax 10.0
25 pericarditis 10.0
26 hairy cell leukemia 10.0
27 acute pancreatitis 10.0
28 purpura 10.0
29 plague 10.0
30 lupus erythematosus 10.0
31 pneumothorax, primary spontaneous 9.8
32 thrombophilia due to thrombin defect 9.8
33 sickle cell anemia 9.8
34 myocardial infarction 9.8
35 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.8
36 acute myocardial infarction 9.8
37 adult respiratory distress syndrome 9.8
38 alopecia 9.8
39 burns 9.8
40 liver cirrhosis 9.8
41 pulmonary fibrosis 9.8
42 erythema multiforme 9.8
43 hypophosphatemia 9.8
44 lymphoma 9.8
45 lung abscess 9.8
46 thrombotic thrombocytopenic purpura 9.8
47 respiratory failure 9.8
48 disseminated intravascular coagulation 9.8
49 chlamydia 9.8
50 crescentic glomerulonephritis 9.8

Graphical network of the top 20 diseases related to Legionnaire Disease:



Diseases related to Legionnaire Disease
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Symptoms & Phenotypes for Legionnaire Disease

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Clinical features from OMIM:

608556

UMLS symptoms related to Legionnaire Disease:


fever, pruritus, snoring, coughing
Sources

Drugs & Therapeutics for Legionnaire Disease

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Drugs for Legionnaire Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
5
Tazobactam Approved Phase 4 89786-04-9 123630
6
Moxifloxacin Approved, Investigational Phase 4,Phase 1 354812-41-2, 151096-09-2 152946
7
Polyestradiol phosphate Approved Phase 4,Phase 1 28014-46-2
8
Piperacillin Approved Phase 4 66258-76-2 43672
9
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
10
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
11
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
12
Ofloxacin Approved Phase 4 82419-36-1 4583
13
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
14
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 1 50-28-2 5757
15
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
16
Norgestimate Approved, Investigational Phase 4,Phase 1 35189-28-7 6540478
17 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 1 979-32-8
18 Anti-Bacterial Agents Phase 4,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 1
20 Anti-Infective Agents Phase 4,Phase 1
21 Antitubercular Agents Phase 4,Phase 1
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 Erythromycin stearate Phase 4
24 Cytochrome P-450 CYP3A Inhibitors Phase 4
25 Erythromycin Estolate Phase 4
26 Erythromycin Ethylsuccinate Phase 4
27 Estradiol 3-benzoate Phase 4,Phase 1
28 Penicillanic Acid Phase 4
29 Contraceptives, Oral Phase 4,Phase 1
30 Hydrocortisone-17-butyrate Phase 4
31 Renal Agents Phase 4
32 Topoisomerase Inhibitors Phase 4,Phase 1
33 Estradiol 17 beta-cypionate Phase 4,Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 1
35 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
36 Anti-Inflammatory Agents Phase 4
37 Cephalosporins Phase 4
38 Contraceptives, Oral, Combined Phase 4,Phase 1
39 Hydrocortisone 17-butyrate 21-propionate Phase 4
40 Clavulanic Acids Phase 4
41 Anti-Infective Agents, Urinary Phase 4
42 Piperacillin, tazobactam drug combination Phase 4
43 Fluoroquinolones Phase 4,Phase 1
44 Amoxicillin-Potassium Clavulanate Combination Phase 4
45 Cortisol succinate Phase 4
46 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 1
47 beta-Lactamase Inhibitors Phase 4
48 Contraceptive Agents Phase 4,Phase 1
49
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
50
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia Recruiting NCT02735707 Phase 4 Hydrocortisone;Ceftriaxone;Moxifloxacin or Levofloxacin;Piperacillin tazobactam;Ceftaroline;Amoxicillin Clavulanate;Macrolide administered for 3 days;Macrolide administered for up to 14 days
3 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
4 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
5 Legionnaires' Effect on Smell Recruiting NCT03321786
6 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153 Not Applicable
7 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
8 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Recruiting NCT03064737 Not Applicable
9 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
10 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
11 Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed NCT01922024

Search NIH Clinical Center for Legionnaire Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Legionnaire Disease

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Anatomical Context for Legionnaire Disease

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MalaCards organs/tissues related to Legionnaire Disease:

41
Lung, Testes, Bone, Monocytes, Bone Marrow, Colon, Liver
Sources

Publications for Legionnaire Disease

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Articles related to Legionnaire Disease:

(show top 50) (show all 1129)
# Title Authors Year
1
Environmental sources of community-acquired legionnaires' disease: A review. ( 29729999 )
2018
2
Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017. ( 29744757 )
2018
3
Complete Genome Sequence of<i>Legionella sainthelensi</i>Isolated from a Patient with Legionnaires' Disease. ( 29437115 )
2018
4
Fever of unknown origin due to Legionnaires' disease: A diagnostic challenge. ( 29412169 )
2018
5
Legionnaires' Disease and Use of Water Dispensers With an Ultraviolet Sterilizer. ( 29493477 )
2018
6
The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms. ( 29572569 )
2018
7
Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29432149 )
2018
8
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. ( 29298342 )
2018
9
A Case Note on Legionnaires' Disease Caused by Serogroup 1, Sequence Type ST496 in Singapore. ( 29911737 )
2018
10
Legionnaires' Disease Outbreak on a Merchant Vessel, Indian Ocean, Australia, 2015. ( 29912714 )
2018
11
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
12
Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015. ( 29386076 )
2018
13
Lessons Learnt From Exercise Celestial Navigation: The Application of a Geographic Information System to Inform Legionnaires' Disease Control Activity. ( 29716666 )
2018
14
Correction for Zahran et al., Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29891661 )
2018
15
Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas. ( 29559643 )
2018
16
Legionnaires' disease at a medical center in southern Taiwan. ( 28094205 )
2018
17
Rapid Identification of a Cooling Tower-Associated Legionnaires' Disease Outbreak Supported by Polymerase Chain Reaction Testing of Environmental Samples, New York City, 2014-2015. ( 29780175 )
2018
18
Sensitivity and Positive Predictive Value of Death Certificate Data Among Deaths Caused by Legionnaires' Disease in New York City, 2008-2013. ( 30005174 )
2018
19
Timeliness of travel-associated Legionnaires' disease surveillance. ( 30102506 )
2018
20
Searching for Pediatric Legionnaire Disease in a Population With High Adult Incidence. ( 30102670 )
2018
21
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: A case report. ( 30122733 )
2018
22
Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181540 )
2018
23
Author Response to Comments on "Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas". ( 30181566 )
2018
24
Clusters of Healthcare-Associated Legionnaires' Disease in Two Hospitals of Central Greece. ( 30186646 )
2018
25
Two Community Clusters of Legionnaires' Disease Directly Linked to a Biologic Wastewater Treatment Plant, the Netherlands. ( 30226165 )
2018
26
Legionnaires' disease as an occupational risk related to decontamination work after the Fukushima nuclear disaster: a case report. ( 30259881 )
2018
27
Preventing hospital-acquired Legionnaires' disease: A snapshot of clinical practices and water management approaches in US acute-care hospitals. ( 30293535 )
2018
28
Simulation of Legionnaires' disease prospective spatiotemporal cluster detection, Allegheny County, Pennsylvania, USA. ( 30334502 )
2018
29
Legionella and Legionnaires' disease: Time to explore in India. ( 30429383 )
2018
30
Travel-associated Legionnaires' disease: would changing cluster definition lead to the prevention of a larger number of cases? ( 30501676 )
2018
31
A community outbreak of Legionnaires' disease in Geneva, Switzerland, June to September 2017. ( 30552854 )
2018
32
Why Are Legionnaires Disease Diagnoses Becoming More Common in the United States? ( 29641815 )
2018
33
Community-acquired Legionnaires' disease at a medical center in northern Taiwan. ( 28964650 )
2017
34
Legionnaires' disease in transplant recipients: A 15-year retrospective study in a tertiary referral center. ( 28696077 )
2017
35
Legionnaires' Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases. ( 28615983 )
2017
36
Distribution System Operational Deficiencies Coincide with Reported Legionnaires' Disease Clusters in Flint, Michigan. ( 28849909 )
2017
37
Increase in Legionnaires' disease cases associated with travel to Dubai among travellers from the United Kingdom, Sweden and the Netherlands, October 2016 to end August 2017. ( 28935023 )
2017
38
Legionnaires' Disease (Legionella Infection) ( 28613558 )
2017
39
Short-term effects of atmospheric pressure, temperature, and rainfall on notification rate of community-acquired Legionnaires' disease in four European countries - CORRIGENDUM. ( 29032771 )
2017
40
Lessons Learned From Implementing an Incident Command System During a Local Multiagency Response to a Legionnaires' Disease Cluster in Sydney, NSW. ( 28870277 )
2017
41
Healthcare-associated Legionnaires' disease: Limitations of surveillance definitions and importance of epidemiologic investigation. ( 29344101 )
2017
42
Diagnostic testing for Legionnaires' disease. ( 28851372 )
2017
43
Early Radiographic and Tomographic Manifestations of Legionnaires' Disease. ( 28479105 )
2017
44
Vital Signs: Health Care-Associated Legionnaires' Disease Surveillance Data from 20 States and a Large Metropolitan Area - United States, 2015. ( 28594788 )
2017
45
Legionnaires' Disease As An Occupational Risk Related To Decontamination Work After The Fukushima Nuclear Disaster: A Case Report. ( 29311436 )
2017
46
Accuracy of diagnostic tests for Legionnaires' disease: a systematic review. ( 28463665 )
2017
47
Legionnaires' Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015. ( 29047425 )
2017
48
Vital Signs: Health Care-Associated Legionnaires' Disease Surveillance Data From 20 States and a Large Metropolitan Area-United States, 2015. ( 28724206 )
2017
49
Complete Genome Sequence of a Legionella longbeachae Serogroup 1 Strain Isolated from a Patient with Legionnaires' Disease. ( 28619815 )
2017
50
Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease. ( 28622979 )
2017
Sources

Variations for Legionnaire Disease

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ClinVar genetic disease variations for Legionnaire Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh37 Chromosome 1, 223285200: 223285200
2 TLR5 NM_003268.5(TLR5): c.1174C> T (p.Arg392Ter) single nucleotide variant protective,risk factor rs5744168 GRCh38 Chromosome 1, 223111858: 223111858
3 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh37 Chromosome 1, 223284599: 223284599
4 TLR5 NM_003268.5(TLR5): c.1775A> G (p.Asn592Ser) single nucleotide variant risk factor rs2072493 GRCh38 Chromosome 1, 223111257: 223111257
Sources

Expression for Legionnaire Disease

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Search GEO for disease gene expression data for Legionnaire Disease.
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Pathways for Legionnaire Disease

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Pathways related to Legionnaire Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development Slit-Robo signaling 22
Show member pathways
 11.11 KRT18 TLR5
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GO Terms for Legionnaire Disease

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Sources for Legionnaire Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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