Aliases & Classifications for Legionnaires' Disease

MalaCards integrated aliases for Legionnaires' Disease:

Name: Legionnaires' Disease 12 76 43 3 44 15 73
Infection by Legionella Pneumophilia 12
Legionnaire's Disease 12
Legionella Pneumonia 12
Legionella 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10457
ICD10 33 A48.1
ICD9CM 35 482.84
MeSH 44 D007877
UMLS 73 C0023241

Summaries for Legionnaires' Disease

MedlinePlus : 43 Legionnaires' disease is a type of pneumonia caused by bacteria. You usually get it by breathing in mist from water that contains the bacteria. The mist may come from hot tubs, showers, or air-conditioning units for large buildings. The bacteria don't spread from person to person. Symptoms of Legionnaires' disease include high fever, chills, a cough, and sometimes muscle aches and headaches. Other types of pneumonia have similar symptoms. You will probably need a chest x-ray to diagnose the pneumonia. Lab tests can detect the specific bacteria that cause Legionnaires' disease. Most people exposed to the bacteria do not become sick. You are more likely to get sick if you Are older than 50 Smoke Have a chronic lung disease Have a weak immune system Legionnaires' disease is serious and can be life-threatening. However, most people recover with antibiotic treatment. Centers for Disease Control and Prevention

MalaCards based summary : Legionnaires' Disease, also known as infection by legionella pneumophilia, is related to legionellosis and glomerulonephritis, and has symptoms including coughing, fever and pruritus. An important gene associated with Legionnaires' Disease is TLR5 (Toll Like Receptor 5), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and IL-2 Pathway. The drugs Azithromycin and Clarithromycin have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and colon, and related phenotypes are cellular and immune system

CDC : 3 Legionnaires’ (LEE-juh-nares) disease is a serious type of pneumonia (lung infection) caused by Legionella (LEE-juh-nell-a) bacteria. Legionella can also cause a milder illness called Pontiac fever. People can get sick when they breathe in mist or accidently swallow water into the lungs containing Legionella. Most people exposed to Legionella do not get sick. However, people 50 years or older, current or former smokers, and people with a weakened immune system or chronic disease are at increased risk.

Disease Ontology : 12 A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

Wikipedia : 76 Legionnaires\' disease is a form of atypical pneumonia caused by any type of Legionella bacteria. Signs... more...

Related Diseases for Legionnaires' Disease

Diseases related to Legionnaires' Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 legionellosis 32.2 CD40LG NLRC4 PIK3C2A TLR4 TLR5
2 glomerulonephritis 29.6 ALB CD40LG TLR9
3 pneumonia 29.5 CD40LG PIK3C2A TLR4 TLR5 TLR9
4 typhoid fever 29.5 ALB OMP TLR4 TLR5
5 legionnaire disease 12.5
6 pontiac fever 10.7
7 penicilliosis 10.7 TLR4 TLR6
8 anteroseptal myocardial infarction 10.6 ALB PIK3C2A
9 kwashiorkor 10.5 ALB SLC17A5
10 trichostrongyloidiasis 10.5 CD40LG PIK3C2A
11 anuria 10.5 ALB PIK3C2A
12 irak4 deficiency 10.5 TLR4 TLR5 TLR6
13 myd88 deficiency 10.5 TLR4 TLR5 TLR6
14 ornithosis 10.5 CD40LG PIK3C2A
15 trench fever 10.5 CD40LG TLR4
16 coccidioidomycosis 10.5 CD40LG TLR4
17 trichinosis 10.5 CD40LG PIK3C2A
18 enterocolitis 10.4 NLRC4 TLR4
19 urethritis 10.4 CD40LG TLR6
20 rocky mountain spotted fever 10.4 CD40LG SLC17A5
21 neisseria meningitidis infection 10.4 OMP TLR4
22 fascioliasis 10.4 ALB SLC17A5
23 colorado tick fever 10.4 ALB CD40LG
24 cork-handlers' disease 10.4 ALB CD40LG
25 plasmodium malariae malaria 10.3 ALB CD40LG
26 fournier gangrene 10.3 ALB CD40LG
27 ariboflavinosis 10.3 ALB TLR4 TLR6
28 yellow nail syndrome 10.3 ALB CD40LG
29 compartment syndrome 10.3 ALB PIK3C2A SLC17A5
30 background diabetic retinopathy 10.3 ALB TLR9
31 pyelitis 10.3 CD40LG TLR4
32 diffuse glomerulonephritis 10.3 ALB CD40LG
33 cystic echinococcosis 10.3 CD40LG TLR4
34 splenic disease 10.3 ALB CD40LG
35 aleutian mink disease 10.3 ALB CD40LG
36 suppurative otitis media 10.3 CD40LG TLR4 TLR5
37 periodontosis 10.2 CD40LG TLR4
38 myositis fibrosa 10.2 PIK3C2A TLR4 TLR9
39 non-secretory myeloma 10.2 ALB CD40LG
40 transient arthritis 10.2 ALB CD40LG
41 bacteriuria 10.2 CD40LG TLR4
42 septic arthritis 10.2 TLR4 TLR5
43 pelvic inflammatory disease 10.2 CD40LG TLR4 TLR6
44 hypersensitivity reaction type iii disease 10.2 ALB CD40LG
45 invasive aspergillosis 10.2 TLR4 TLR6 TLR9
46 vasomotor rhinitis 10.2 CD40LG TLR9
47 scrub typhus 10.1 CD40LG SLC17A5 TLR4
48 salmonellosis 10.1 ALB NLRC4 TLR4
49 central nervous system vasculitis 10.1 CD40LG TLR9
50 bacterial meningitis 10.1 ALB PIK3C2A TLR9

Graphical network of the top 20 diseases related to Legionnaires' Disease:



Diseases related to Legionnaires' Disease

Symptoms & Phenotypes for Legionnaires' Disease

UMLS symptoms related to Legionnaires' Disease:


coughing, fever, pruritus, snoring

MGI Mouse Phenotypes related to Legionnaires' Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.81 SLC17A5 TLR4 TLR5 TLR9 ALB CD40LG
2 immune system MP:0005387 9.56 PIK3C2A TLR4 TLR5 TLR6 TLR9 CANX
3 mortality/aging MP:0010768 9.32 PIK3C2A SLC17A5 TLR4 TLR5 TLR9 ALB

Drugs & Therapeutics for Legionnaires' Disease

Drugs for Legionnaires' Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Clarithromycin Approved Phase 4 81103-11-9 84029
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
4 Anti-Bacterial Agents Phase 4,Phase 1
5 Antibiotics, Antitubercular Phase 4,Phase 1
6 Anti-Infective Agents Phase 4,Phase 1
7 Antitubercular Agents Phase 4,Phase 1
8 Cytochrome P-450 CYP3A Inhibitors Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Erythromycin Estolate Phase 4
11 Erythromycin Ethylsuccinate Phase 4
12 Erythromycin stearate Phase 4
13
Estradiol Approved, Investigational, Vet_approved Phase 1 50-28-2 5757
14 Estradiol valerate Approved, Investigational, Vet_approved Phase 1 979-32-8
15
Ethinyl Estradiol Approved Phase 1 57-63-6 5991
16
Isoniazid Approved, Investigational Phase 1 54-85-3 3767
17
Kanamycin Approved, Investigational, Vet_approved Phase 1 8063-07-8, 59-01-8 6032
18
Moxifloxacin Approved, Investigational Phase 1 354812-41-2, 151096-09-2 152946
19
Norgestimate Approved, Investigational Phase 1 35189-28-7 6540478
20
Polyestradiol phosphate Approved Phase 1 28014-46-2
21
Pyrazinamide Approved, Investigational Phase 1 98-96-4 1046
22
Rifampicin Approved Phase 1 13292-46-1 5458213 5381226
23
Streptomycin Approved, Vet_approved Phase 1 57-92-1 19649
24
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
25
Nicotinamide Approved, Investigational, Nutraceutical Phase 1 98-92-0 936
26 Antimetabolites Phase 1
27 Catalase Phase 1
28 Contraceptive Agents Phase 1
29 Contraceptives, Oral Phase 1
30 Contraceptives, Oral, Combined Phase 1
31 Cytochrome P-450 CYP3A Inducers Phase 1
32 Estradiol 17 beta-cypionate Phase 1
33 Estradiol 3-benzoate Phase 1
34 Fluoroquinolones Phase 1
35 Hypolipidemic Agents Phase 1
36 Lipid Regulating Agents Phase 1
37 Nicotinic Acids Phase 1
38 Norgestimate, ethinyl estradiol drug combination Phase 1
39 Nucleic Acid Synthesis Inhibitors Phase 1
40 Topoisomerase Inhibitors Phase 1
41 Vitamin B3 Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
2 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
3 Severe Legionellosis Cases Admitted to Grenoble University Hospital, 2006-2011. Completed NCT02884700
4 Special Investigation Of Azithromycin IV For Legionnaires' Disease (Regulatory Post Marketing Commitment Plan) Completed NCT01784770 Azithromycin IV
5 Community Acquired Pneumonia in Telemark and Ostfold Completed NCT00467701
6 Detection of Microorganisms and Antibiotic Resistance Genes Using the Curetis Unyvero LRT55 Application Completed NCT01922024
7 Legionnaires' Effect on Smell Recruiting NCT03321786
8 Impact of Legionella Urine Antigen Testing (LUAT) on the Local Epidemiology and Diagnosis of Legionella Pneumonia Not yet recruiting NCT03200275
9 Bacterial and Human Biomarkers of Prognostic Value for Severe Legionnaire's Disease Not yet recruiting NCT03064737 Not Applicable
10 Evaluation of Legionella PCR Techniques for the Routine Diagnosis of Legionellosis Terminated NCT00452153 Not Applicable

Search NIH Clinical Center for Legionnaires' Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: legionnaires' disease

Genetic Tests for Legionnaires' Disease

Anatomical Context for Legionnaires' Disease

MalaCards organs/tissues related to Legionnaires' Disease:

41
Lung, Testes, Colon, Bone Marrow, Bone, Liver, Heart

Publications for Legionnaires' Disease

Articles related to Legionnaires' Disease:

(show top 50) (show all 581)
# Title Authors Year
1
Environmental sources of community-acquired legionnaires' disease: A review. ( 29729999 )
2018
2
Outbreaks of Legionnaires' Disease and Pontiac Fever 2006-2017. ( 29744757 )
2018
3
Complete Genome Sequence of<i>Legionella sainthelensi</i>Isolated from a Patient with Legionnaires' Disease. ( 29437115 )
2018
4
Fever of unknown origin due to Legionnaires' disease: A diagnostic challenge. ( 29412169 )
2018
5
Legionnaires' Disease and Use of Water Dispensers With an Ultraviolet Sterilizer. ( 29493477 )
2018
6
The unprecedented 2014 Legionnaires' disease outbreak in Portugal: atmospheric driving mechanisms. ( 29572569 )
2018
7
Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29432149 )
2018
8
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans. ( 29298342 )
2018
9
A Case Note on Legionnaires' Disease Caused by Serogroup 1, Sequence Type ST496 in Singapore. ( 29911737 )
2018
10
Legionnaires' Disease Outbreak on a Merchant Vessel, Indian Ocean, Australia, 2015. ( 29912714 )
2018
11
Study of the radiologic features of Legionnaires' disease with mediastinal adenopathy: Legionella or lymphoma? ( 29383455 )
2018
12
Outbreak of Legionnaires' disease associated with cooling towers at a California state prison, 2015. ( 29386076 )
2018
13
Lessons Learnt From Exercise Celestial Navigation: The Application of a Geographic Information System to Inform Legionnaires' Disease Control Activity. ( 29716666 )
2018
14
Correction for Zahran et al., Assessment of the Legionnaires' disease outbreak in Flint, Michigan. ( 29891661 )
2018
15
Rolling epidemic of Legionnaires' disease outbreaks in small geographic areas. ( 29559643 )
2018
16
Rapid Identification of a Cooling Tower-Associated Legionnaires' Disease Outbreak Supported by Polymerase Chain Reaction Testing of Environmental Samples, New York City, 2014-2015. ( 29780175 )
2018
17
Community-acquired Legionnaires' disease at a medical center in northern Taiwan. ( 28964650 )
2017
18
Legionnaires' disease in transplant recipients: A 15-year retrospective study in a tertiary referral center. ( 28696077 )
2017
19
Legionnaires' Disease: Clinicoradiological Comparison of Sporadic Versus Outbreak Cases. ( 28615983 )
2017
20
Distribution System Operational Deficiencies Coincide with Reported Legionnaires' Disease Clusters in Flint, Michigan. ( 28849909 )
2017
21
Increase in Legionnaires' disease cases associated with travel to Dubai among travellers from the United Kingdom, Sweden and the Netherlands, October 2016 to end August 2017. ( 28935023 )
2017
22
Legionnaires' Disease (Legionella Infection) ( 28613558 )
2017
23
Short-term effects of atmospheric pressure, temperature, and rainfall on notification rate of community-acquired Legionnaires' disease in four European countries - CORRIGENDUM. ( 29032771 )
2017
24
Lessons Learned From Implementing an Incident Command System During a Local Multiagency Response to a Legionnaires' Disease Cluster in Sydney, NSW. ( 28870277 )
2017
25
Healthcare-associated Legionnaires' disease: Limitations of surveillance definitions and importance of epidemiologic investigation. ( 29344101 )
2017
26
Diagnostic testing for Legionnaires' disease. ( 28851372 )
2017
27
Early Radiographic and Tomographic Manifestations of Legionnaires' Disease. ( 28479105 )
2017
28
Vital Signs: Health Care-Associated Legionnaires' Disease Surveillance Data from 20 States and a Large Metropolitan Area - United States, 2015. ( 28594788 )
2017
29
Legionnaires' Disease As An Occupational Risk Related To Decontamination Work After The Fukushima Nuclear Disaster: A Case Report. ( 29311436 )
2017
30
Accuracy of diagnostic tests for Legionnaires' disease: a systematic review. ( 28463665 )
2017
31
Legionnaires' Disease Outbreak Caused by Endemic Strain of Legionella pneumophila, New York, New York, USA, 2015. ( 29047425 )
2017
32
Vital Signs: Health Care-Associated Legionnaires' Disease Surveillance Data From 20 States and a Large Metropolitan Area-United States, 2015. ( 28724206 )
2017
33
Complete Genome Sequence of a Legionella longbeachae Serogroup 1 Strain Isolated from a Patient with Legionnaires' Disease. ( 28619815 )
2017
34
Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease. ( 28622979 )
2017
35
Weather-Dependent Risk for Legionnaires' Disease, United States. ( 29048279 )
2017
36
Legionnaires' disease from a dental unit. Chicken-and-egg or a different source entirely? ( 28412175 )
2017
37
Community-acquired Legionnaires' Disease in a Newly Constructed Apartment Building. ( 28768406 )
2017
38
Authors' response: Legionnaires' disease following the Christchurch earthquakes. ( 28934775 )
2017
39
Risk Factors for Legionella longbeachae Legionnaires' Disease, New Zealand. ( 28628460 )
2017
40
Legionnaires' Disease Outbreaks and Cooling Towers, New York City, New York, USA. ( 29049017 )
2017
41
Legionnaires' Disease Complicated with Rhabdomyolysis and Acute Kidney Injury in an AIDS Patient. ( 29109879 )
2017
42
Legionnaires' disease in Europe, 2011 to 2015. ( 28703097 )
2017
43
Notes from the Field: Two Cases of Legionnaires' Disease in Newborns After Water Births - Arizona, 2016. ( 28594785 )
2017
44
Tigecycline as a Second-Line Agent for Legionnaires' Disease in Severely Ill Patients. ( 29026871 )
2017
45
Vital Signs: Deficiencies in Environmental Control Identified in Outbreaks of Legionnaires' Disease-North America, 2000-2014. ( 28497871 )
2016
46
Work participation in Q-fever patients and patients with Legionnaires' disease: A 12-month cohort study. ( 25724468 )
2015
47
Comparative analysis of virulence traits between a Legionella feeleii strain implicated in Pontiac fever and a strain that caused Legionnaires' disease. ( 26386398 )
2015
48
Characterization of the extent of a large outbreak of Legionnaires' disease by serological assays. ( 25887275 )
2015
49
Imipenem therapy for Legionnaires' disease. ( 25443312 )
2015
50
The Importance of Clinical Surveillance in Detecting Legionnaires' Disease Outbreaks: A Large Outbreak in a Hospital With a Legionella Disinfection System-Pennsylvania, 2011-2012. ( 25722201 )
2015

Variations for Legionnaires' Disease

Expression for Legionnaires' Disease

Search GEO for disease gene expression data for Legionnaires' Disease.

Pathways for Legionnaires' Disease

Pathways related to Legionnaires' Disease according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 NLRC4 TLR4 TLR5 TLR6 TLR9
2
Show member pathways
12.57 PIK3C2A TLR4 TLR5 TLR6 TLR9
3
Show member pathways
12.38 CD40LG TLR4 TLR5 TLR6 TLR9
4
Show member pathways
12.2 TLR4 TLR5 TLR6 TLR9
5
Show member pathways
12.04 TLR4 TLR5 TLR6 TLR9
6
Show member pathways
12.01 TLR4 TLR5 TLR6 TLR9
7 11.99 TLR4 TLR6 TLR9
8 11.91 CANX TLR4 TLR6
9
Show member pathways
11.89 CD40LG TLR4 TLR5 TLR6 TLR9
10
Show member pathways
11.84 TLR4 TLR5 TLR6 TLR9
11 11.78 TLR4 TLR5 TLR6 TLR9
12 11.62 NLRC4 TLR4 TLR5
13 11.39 NLRC4 TLR4 TLR5
14 11.39 TLR4 TLR5 TLR6 TLR9
15 11.27 CD40LG TLR4 TLR9
16
Show member pathways
11.11 PIK3C2A TLR4 TLR5 TLR6 TLR9
17 11.07 CD40LG TLR4

GO Terms for Legionnaires' Disease

Biological processes related to Legionnaires' Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 NLRC4 TLR4 TLR5 TLR6 TLR9
2 innate immune response GO:0045087 9.96 NLRC4 TLR4 TLR5 TLR6 TLR9
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.81 TLR4 TLR6 TLR9
4 inflammatory response GO:0006954 9.8 CD40LG NLRC4 TLR4 TLR5 TLR6 TLR9
5 defense response to bacterium GO:0042742 9.77 NLRC4 TLR4 TLR5 TLR6 TLR9
6 toll-like receptor signaling pathway GO:0002224 9.69 TLR4 TLR6 TLR9
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 TLR4 TLR5 TLR6
8 cellular response to amyloid-beta GO:1904646 9.65 TLR4 TLR6
9 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.65 TLR4 TLR6
10 negative regulation of interleukin-6 production GO:0032715 9.64 TLR4 TLR9
11 positive regulation of interferon-beta production GO:0032728 9.64 TLR4 TLR9
12 activation of innate immune response GO:0002218 9.63 NLRC4 TLR4
13 positive regulation of interleukin-8 production GO:0032757 9.63 TLR4 TLR5 TLR9
14 positive regulation of chemokine production GO:0032722 9.62 TLR4 TLR9
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.62 TLR4 TLR6
16 positive regulation of macrophage activation GO:0043032 9.61 TLR4 TLR6
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 TLR4 TLR9
18 positive regulation of interleukin-12 production GO:0032735 9.61 CD40LG TLR4 TLR9
19 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.6 TLR4 TLR6
20 I-kappaB phosphorylation GO:0007252 9.59 TLR4 TLR9
21 T-helper 1 type immune response GO:0042088 9.58 TLR4 TLR6
22 positive regulation of interleukin-10 production GO:0032733 9.58 CD40LG TLR4 TLR9
23 positive regulation of interferon-beta biosynthetic process GO:0045359 9.57 TLR4 TLR9
24 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.55 TLR4 TLR6
25 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.55 CD40LG NLRC4 TLR4 TLR6 TLR9
26 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.54 TLR4 TLR6
27 positive regulation of toll-like receptor signaling pathway GO:0034123 9.52 TLR5 TLR9
28 positive regulation of oxidative stress-induced neuron death GO:1903223 9.48 TLR4 TLR6
29 interleukin-1 beta secretion GO:0050702 9.43 NLRC4 TLR4 TLR6
30 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.26 TLR4 TLR5 TLR6 TLR9
31 regulation of cytokine secretion GO:0050707 8.92 TLR4 TLR5 TLR6 TLR9

Molecular functions related to Legionnaires' Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 TLR5 TLR9
2 transmembrane signaling receptor activity GO:0004888 8.92 TLR4 TLR5 TLR6 TLR9

Sources for Legionnaires' Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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