MCID: LGM010
MIFTS: 29

Legume Allergy

Categories: Immune diseases
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Aliases & Classifications for Legume Allergy

MalaCards integrated aliases for Legume Allergy:

Name: Legume Allergy 11 14
Fabaceae Allergy 11

Classifications:



External Ids:

Disease Ontology 11 DOID:0060904

Summaries for Legume Allergy

Disease Ontology: 11 A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product.

MalaCards based summary: Legume Allergy, also known as fabaceae allergy, is related to chronic rhinitis and allergic rhinitis. An important gene associated with Legume Allergy is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. Affiliated tissues include kidney, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Legume Allergy

Diseases related to Legume Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 443)
# Related Disease Score Top Affiliating Genes
1 chronic rhinitis 29.8 PEDS1 PDCL IL5 IL4 IL33 IL13
2 allergic rhinitis 29.8 IL9 IL5 IL4 IL13 IL10
3 rhinitis 29.1 TSLP IL9 IL5 IL4 IL33 IL13
4 peanut allergy 28.7 TSLP SCP2 PEDS1 PDCL IL9 IL5
5 food allergy 28.0 TSLP SCP2 PEDS1 PDCL IL9 IL5
6 dermatitis, atopic 27.5 TSLP SPINK5 PEDS1 IL9 IL5 IL4
7 aztreonam allergy 10.4 IL5 IL13
8 photoallergic dermatitis 10.4 FLG CCR6
9 nickel allergic contact dermatitis 10.4 IL5 IL13
10 timothy grass allergy 10.4 PEDS1 PDCL
11 respiratory syncytial virus infectious disease 10.4 IL5 IL13
12 crab allergy 10.3 PEDS1 ENPP3
13 apricot allergy 10.3 PEDS1 ENPP3
14 chicken egg allergy 10.3 SCP2 FLG
15 enterobiasis 10.3 IL5 IL4
16 fish allergy 10.3 PEDS1 PDCL
17 nasopharyngitis 10.3 IL5 IL13 CCR6
18 vernal keratoconjunctivitis 10.3 IL4 IL13
19 keratoconjunctivitis 10.3 IL5 IL4 IL13
20 papillary conjunctivitis 10.3 IL5 IL4 IL13
21 cough variant asthma 10.3 IL5 IL4 IL13
22 tomato allergy 10.3 SCP2 PDCL
23 eosinophilic meningitis 10.3 IL5 IL4 IL13
24 aspirin-induced respiratory disease 10.3 IL5 IL13
25 vasomotor rhinitis 10.3 IL5 IL4 IL13
26 giant papillary conjunctivitis 10.3 IL5 IL4 IL13
27 scleritis 10.3 IL5 IL4 CCR6
28 angiostrongyliasis 10.3 IL5 IL13
29 eosinophilic gastritis 10.3 TSLP IL5 IL13
30 eosinophilic pneumonia 10.3 IL5 IL4 IL13
31 ceftriaxone allergy 10.3 PEDS1 IL10
32 cercarial dermatitis 10.3 IL5 IL4
33 eosinophilic gastroenteritis 10.3 IL5 IL4 IL13
34 rocuronium allergy 10.3 PEDS1 CD63
35 vernal conjunctivitis 10.3 PDCL IL4
36 kimura disease 10.3 IL5 IL4
37 erythema multiforme 10.3 IL5 IL4 IL13
38 onchocerciasis 10.3 IL5 IL4 IL13
39 pulmonary eosinophilia 10.3 IL5 IL4 IL13
40 orange allergy 10.3 SCP2 PDCL IL5
41 loeffler syndrome 10.3 IL5 IL33 IL13
42 goat milk allergy 10.3 TSLP IL33
43 gastroduodenitis 10.3 CD4 CCR6
44 candidiasis 10.3 IL5 IL4 IL10
45 adult-onset severe asthma 10.3 TSLP CCR6
46 inflammatory bowel disease 18 10.2 IL4 IL10 CCR6
47 chronic ethmoiditis 10.2 TSLP IL33
48 amoxicillin allergy 10.2 ENPP3 CD63
49 thymic dysplasia 10.2 ICOSLG CD4
50 progressive relapsing multiple sclerosis 10.2 ICOSLG CD4 CCR6

Graphical network of the top 20 diseases related to Legume Allergy:



Diseases related to Legume Allergy

Symptoms & Phenotypes for Legume Allergy

MGI Mouse Phenotypes related to Legume Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 CCR6 CD4 CD63 FOXP3 ICOSLG IL10
2 digestive/alimentary MP:0005381 10 CD4 CD63 ENPP3 FOXP3 IL10 IL13
3 immune system MP:0005387 10 CCR6 CD4 ENPP3 FOXP3 ICOSLG IL10
4 respiratory system MP:0005388 9.56 ENPP3 FOXP3 IL10 IL13 IL33 IL4
5 hematopoietic system MP:0005397 9.47 CCR6 CD4 ENPP3 FOXP3 ICOSLG IL10

Drugs & Therapeutics for Legume Allergy

Search Clinical Trials, NIH Clinical Center for Legume Allergy

Genetic Tests for Legume Allergy

Anatomical Context for Legume Allergy

Organs/tissues related to Legume Allergy:

MalaCards : Kidney

Publications for Legume Allergy

Articles related to Legume Allergy:

(show all 19)
# Title Authors PMID Year
1
IgE mediated legume allergy in east Mediterranean children: A reflection of multiple food allergies. 62
35470935 2022
2
Adult and Pediatric Food Allergy to Chickpea, Pea, Lentil, and Lupine: A Scoping Review. 62
33166732 2021
3
Occupational airborne contact urticaria, anaphylaxis and asthma in farmers and agronomists due to Bruchus pisorum. 62
32592184 2020
4
Is it necessary to avoid all legumes in legume allergy? 62
32408382 2020
5
Propofol use in children with allergies to egg, peanut, soybean or other legumes. 62
31077340 2019
6
Cross-reactivity of a new food ingredient, dun pea, with legumes, and risk of anaphylaxis in legume allergic children. 62
26159477 2015
7
Grain and legume allergy. 62
26022874 2015
8
Variably severe systemic allergic reactions after consuming foods with unlabelled lupin flour: a case series. 62
24529316 2014
9
A comprehensive review of legume allergy. 62
22555630 2013
10
Anaphylactic reactions in mice with Fenugreek allergy. 62
21645030 2011
11
Molecular diagnosis of peanut and legume allergy. 62
21464707 2011
12
Kidney bean: a major sensitizer among legumes in asthma and rhinitis patients from India. 62
22096535 2011
13
Lupine, a source of new as well as hidden food allergens. 62
20013885 2010
14
Clinical features of legume allergy in children from a Mediterranean area. 62
18727474 2008
15
Soy allergy in perspective. 62
18560305 2008
16
Prevalence of legume sensitization in patients with naso-bronchial allergy. 62
18618316 2008
17
In vitro and in vivo cross-reactivity studies of legume allergy in a Mediterranean population. 62
18594152 2008
18
[Legume cross-reactivity]. 62
12783766 2003
19
Cross-allergenicity in the legume botanical family in children with food hypersensitivity. 62
2918186 1989

Variations for Legume Allergy

Expression for Legume Allergy

Search GEO for disease gene expression data for Legume Allergy.

Pathways for Legume Allergy

Pathways related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 TSLP IL9 IL5 IL4 IL33 IL13
2
Show member pathways
13.48 CCR6 CD4 IL10 IL13 IL33 IL4
3
Show member pathways
13.31 IL9 IL5 IL4 IL13 IL10 CD4
4
Show member pathways
13.17 IL9 IL5 IL4 IL13 IL10 CD4
5
Show member pathways
13.16 TSLP IL9 IL5 IL4 IL33 IL13
6
Show member pathways
12.53 IL9 IL5 IL4 IL13 IL10
7 12.42 IL4 IL10 FOXP3 ENPP3 CD63
8
Show member pathways
12.02 IL5 IL4 IL10 CD4
9 11.86 IL5 IL4 IL10 CD4
10 11.82 IL5 IL4 IL13 IL10 FOXP3
11 11.67 IL5 IL4 IL13
12 11.63 IL4 IL10 ICOSLG
13 11.61 IL4 FOXP3 CD4
14 11.61 IL5 IL4 IL10
15
Show member pathways
11.59 FOXP3 IL4 IL5
16
Show member pathways
11.57 IL5 IL4 IL13 IL10 FOXP3
17 11.55 IL5 IL4 IL13
18 11.52 IL5 IL4 IL10
19 11.22 IL9 IL5 IL4 IL33 IL13 IL10
20 11.18 IL5 IL4 IL13 IL10 CD4
21 11.18 TSLP IL9 IL5 IL4 IL33 IL13
22 11.17 IL5 IL4 IL13 IL10
23 11.14 TSLP IL9 IL5 IL4 IL33 IL13
24 11.07 IL9 IL5 IL4 IL13 IL10
25 10.92 IL9 IL5 IL4 IL13 IL10
26 10.81 IL4 CD4
27 10.75 IL13 IL4 IL5 IL9

GO Terms for Legume Allergy

Biological processes related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.49 CCR6 CD4 ICOSLG IL10 IL13 IL4
2 immune response GO:0006955 10.21 CCR6 CD4 IL10 IL13 IL4 IL5
3 positive regulation of B cell proliferation GO:0030890 10.04 IL5 IL4 IL13
4 negative regulation of type II interferon production GO:0032689 10.03 IL33 IL10 FOXP3
5 positive regulation of interleukin-10 production GO:0032733 10.02 TSLP IL4 IL13
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.97 IL4 IL13 IL10
7 positive regulation of macrophage activation GO:0043032 9.93 IL33 IL13 IL10
8 T cell activation GO:0042110 9.92 IL4 ICOSLG FOXP3 CD4
9 positive regulation of interleukin-13 production GO:0032736 9.88 TSLP IL4 IL33
10 positive regulation of MHC class II biosynthetic process GO:0045348 9.85 IL4 IL33 IL10
11 regulation of isotype switching GO:0045191 9.83 IL4 IL10
12 negative regulation of chronic inflammatory response GO:0002677 9.81 IL4 FOXP3
13 negative regulation of inflammatory response GO:0050728 9.81 IL4 IL13 IL10 FOXP3 ENPP3
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.78 IL4 IL13
15 positive regulation of interleukin-5 production GO:0032754 9.73 IL33 IL9 TSLP
16 type 2 immune response GO:0042092 9.43 IL4 IL33 IL10
17 positive regulation of immunoglobulin production GO:0002639 9.23 IL5 IL33 IL13 IL10

Molecular functions related to Legume Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.47 TSLP IL9 IL5 IL4 IL33 IL13
2 cytokine receptor binding GO:0005126 9.13 IL9 IL4 IL13

Sources for Legume Allergy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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