Legume Allergy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Legume Allergy

MalaCards integrated aliases for Legume Allergy:

Name: Legume Allergy ¹² ¹⁵

Fabaceae Allergy ¹²

Classifications:

MalaCards categories:
Anatomical: Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060904

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Summaries for Legume Allergy

Disease Ontology : ¹² A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product.

MalaCards based summary : Legume Allergy, also known as fabaceae allergy, is related to peanut allergy and exercise-induced anaphylaxis. An important gene associated with Legume Allergy is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Legume Allergy

Diseases related to Legume Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)

#	Related Disease	Score	Top Affiliating Genes
1	peanut allergy	31.5	PEDS1 PDCL LCOR IL5 IL4 IL13
2	exercise-induced anaphylaxis	30.7	FLG ENPP3
3	food allergy	29.0	SCP2 IL5 IL4 IL13 IL10 FOXP3
4	rhinitis	28.8	TSLP IL5 IL4 IL33 IL13 IL10
5	allergic hypersensitivity disease	28.2	TSLP PEDS1 IL5 IL4 IL33 IL13
6	cytokine deficiency	10.6	IL5 IL13
7	rocuronium allergy	10.5	PEDS1 CD63
8	timothy grass allergy	10.5	PEDS1 PDCL
9	aztreonam allergy	10.5	IL5 IL13
10	angioimmunoblastic lymphadenopathy with dysproteinemia	10.5	IL5 IL13
11	respiratory syncytial virus infectious disease	10.5	IL5 IL13
12	cefuroxime allergy	10.5	IL5 IL13
13	dermatitis, atopic, 3	10.5	TSLP FLG
14	ceftriaxone allergy	10.5	PEDS1 IL5 IL13
15	aneruptive fever	10.5	IL13 FOXP3
16	scleritis	10.4	IL5 IL4 CCR6
17	atopic keratoconjunctivitis	10.4	IL5 IL4
18	cough variant asthma	10.4	IL5 IL4 IL13
19	tropical endomyocardial fibrosis	10.4	IL4 IL10
20	vernal keratoconjunctivitis	10.4	IL5 IL4 IL13
21	angiostrongyliasis	10.4	IL5 IL4 IL13
22	fish allergy	10.4	PEDS1 PDCL
23	cefaclor allergy	10.4	IL5 IL13 CD63
24	apricot allergy	10.4	PEDS1 ENPP3
25	irritant dermatitis	10.4	TSLP IL4 FLG
26	peach allergy	10.4	SCP2 PEDS1 PDCL
27	erythema multiforme	10.4	IL5 IL4 IL13
28	onchocerciasis	10.4	IL5 IL4 IL13
29	chlorhexidine allergy	10.4	PEDS1 ENPP3
30	seborrheic dermatitis	10.4	FLG CD4 CCR6
31	orange allergy	10.3	SCP2 PDCL IL5
32	transient arthritis	10.3	FLG CD4
33	caplan's syndrome	10.3	FOXP3 CD4
34	acute proliferative glomerulonephritis	10.3	ICOSLG CD4 CCR6
35	autoimmune glomerulonephritis	10.3	ICOSLG CD4 CCR6
36	autoimmune disease of urogenital tract	10.3	ICOSLG CD4 CCR6
37	norwegian scabies	10.3	IL5 CD4
38	childhood type dermatomyositis	10.3	ICOSLG CD4 CCR6
39	chronic meningitis	10.3	IL5 IL13 CD4
40	sialadenitis	10.3	ICOSLG CD4 CCR6
41	autoimmune vasculitis	10.3	IL4 CD4 CCR6
42	strongyloidiasis	10.3	IL5 IL13 CD4
43	immunoglobulin alpha deficiency	10.3	ICOSLG CD4 CCR6
44	t cell deficiency	10.3	ICOSLG CD4 CCR6
45	carbapenem allergy	10.3	IL13 ENPP3
46	autoimmune disease of cardiovascular system	10.3	ICOSLG CD4 CCR6
47	keratoconjunctivitis sicca	10.3	IL4 CD4 CCR6
48	blepharitis	10.3	IL4 CD4 CCR6
49	neurodermatitis	10.3	IL4 FLG
50	severe combined immunodeficiency, x-linked	10.3	TSLP IL4 IL13

Graphical network of the top 20 diseases related to Legume Allergy:

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Symptoms & Phenotypes for Legume Allergy

MGI Mouse Phenotypes related to Legume Allergy:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.07	CCR6 CD4 COPS7A ENPP3 FOXP3 IL10
2	homeostasis/metabolism	MP:0005376	10.03	CCR6 CD4 CD63 COPS7A FOXP3 IL10
3	digestive/alimentary	MP:0005381	10.02	CD4 CD63 ENPP3 FOXP3 IL10 IL13
4	immune system	MP:0005387	9.8	CCR6 CD4 COPS7A ENPP3 FOXP3 IL10
5	respiratory system	MP:0005388	9.23	ENPP3 FOXP3 IL10 IL13 IL33 IL4

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Drugs & Therapeutics for Legume Allergy

Search Clinical Trials , NIH Clinical Center for Legume Allergy

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Genetic Tests for Legume Allergy

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Anatomical Context for Legume Allergy

MalaCards organs/tissues related to Legume Allergy:

⁴⁰

Kidney

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Publications for Legume Allergy

Articles related to Legume Allergy:

(show all 16)

#	Title	Authors	PMID	Year
1	Is it necessary to avoid all legumes in legume allergy? ⁶¹	Kakleas K...Noimark L	32408382	2020
2	Propofol use in children with allergies to egg, peanut, soybean or other legumes. ⁶¹	Sommerfield DL...von Ungern-Sternberg BS	31077340	2019
3	Cross-reactivity of a new food ingredient, dun pea, with legumes, and risk of anaphylaxis in legume allergic children. ⁶¹	Richard C...Moneret-Vautrin DA	26159477	2015
4	Grain and legume allergy. ⁶¹	Ito K	26022874	2015
5	Variably severe systemic allergic reactions after consuming foods with unlabelled lupin flour: a case series. ⁶¹	Bansal AS...Hayman GR	24529316	2014
6	A comprehensive review of legume allergy. ⁶¹	Verma AK...Dwivedi PD	22555630	2013
7	Anaphylactic reactions in mice with Fenugreek allergy. ⁶¹	Vinje NE...Lovik M	21645030	2011
8	Molecular diagnosis of peanut and legume allergy. ⁶¹	Nicolaou N...Custovic A	21464707	2011
9	Kidney bean: a major sensitizer among legumes in asthma and rhinitis patients from India. ⁶¹	Kasera R...Singh AB	22096535	2011
10	Lupine, a source of new as well as hidden food allergens. ⁶¹	Jappe U...Vieths S	20013885	2010
11	Clinical features of legume allergy in children from a Mediterranean area. ⁶¹	Martinez San Ireneo M...Fernandez-Caldas E	18727474	2008
12	Soy allergy in perspective. ⁶¹	Ballmer-Weber BK...Vieths S	18560305	2008
13	Prevalence of legume sensitization in patients with naso-bronchial allergy. ⁶¹	Misra A...Dwivedi PD	18618316	2008
14	In vitro and in vivo cross-reactivity studies of legume allergy in a Mediterranean population. ⁶¹	Martinez San Ireneo M...Carnes J	18594152	2008
15	[Legume cross-reactivity]. ⁶¹	Ibanez MD...Fernandez-Caldas E	12783766	2003
16	Cross-allergenicity in the legume botanical family in children with food hypersensitivity. ⁶¹	Bernhisel-Broadbent J...Sampson HA	2918186	1989

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Genes for Legume Allergy

Genes related to Legume Allergy (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.54	DISEASES inferred ¹⁵ ¹⁵
2	PEDS1	Plasmanylethanolamine Desaturase 1	Protein Coding	8.81	DISEASES inferred ¹⁵
3	FLG	Filaggrin	Protein Coding	7.94	DISEASES inferred ¹⁵
4	LCOR	Ligand Dependent Nuclear Receptor Corepressor	Protein Coding	7.77	DISEASES inferred ¹⁵ ¹⁵
5	IL5	Interleukin 5	Protein Coding	7.31	DISEASES inferred ¹⁵
6	IL13	Interleukin 13	Protein Coding	7.3	DISEASES inferred ¹⁵
7	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.2	DISEASES inferred ¹⁵ ¹⁵
8	PDCL	Phosducin Like	Protein Coding	7.13	DISEASES inferred ¹⁵
9	IL4	Interleukin 4	Protein Coding	7.13	DISEASES inferred ¹⁵
10	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	6.99	DISEASES inferred ¹⁵
11	FOXP3	Forkhead Box P3	Protein Coding	6.94	DISEASES inferred ¹⁵
12	CD63	CD63 Molecule	Protein Coding	6.81	DISEASES inferred ¹⁵
13	SCP2	Sterol Carrier Protein 2	Protein Coding	6.8	DISEASES inferred ¹⁵
14	TNXB	Tenascin XB	Protein Coding	6.73	DISEASES inferred ¹⁵
15	CD4	CD4 Molecule	Protein Coding	6.7	DISEASES inferred ¹⁵
16	IL10	Interleukin 10	Protein Coding	6.62	DISEASES inferred ¹⁵
17	ENPP3	Ectonucleotide Pyrophosphatase/Phosphodiesterase 3	Protein Coding	6.59	DISEASES inferred ¹⁵
18	IL33	Interleukin 33	Protein Coding	6.54	DISEASES inferred ¹⁵
19	GHITM	Growth Hormone Inducible Transmembrane Protein	Protein Coding	6.54	DISEASES inferred ¹⁵
20	COPS7A	COP9 Signalosome Subunit 7A	Protein Coding	6.4	DISEASES inferred ¹⁵
21	RARA	Retinoic Acid Receptor Alpha	Protein Coding	6.33	DISEASES inferred ¹⁵
22	PDC	Phosducin	Protein Coding	6.22	DISEASES inferred ¹⁵

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Variations for Legume Allergy

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Expression for Legume Allergy

Search GEO for disease gene expression data for Legume Allergy.

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Pathways for Legume Allergy

Pathways related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.65	IL5 IL4 IL13 IL10 ICOSLG FOXP3
2	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.45	IL5 IL4 IL13 IL10 FOXP3 CD4
3	NF-kappaB Signaling ⁴	12.39	IL4 IL10 FOXP3 ENPP3 CD63
4	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.29	TSLP IL5 IL4 IL13 IL10
5	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.82	IL5 IL4 IL10 CD4
6	Hematopoietic cell lineage ³⁶	11.74	IL5 IL4 CD4
7	Glucocorticoid receptor regulatory network ¹	11.65	IL5 IL4 IL13
8	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.6	IL5 IL4 FOXP3
9	Lung fibrosis ¹	11.51	IL5 IL4 IL13
10	IL4-mediated signaling events ¹	11.5	IL5 IL4 IL10
11	Interleukin-10 signaling ⁶⁵	11.38	IL4 IL13 IL10
12	Development and heterogeneity of the ILC family ¹	11.16	TSLP IL5 IL4 IL33 IL13
13	Th2 Differentiation ⁶⁴	11.16	IL5 IL4 IL33 IL13 IL10 FOXP3
14	Innate Lymphoid Cells Differentiation ⁶⁴	11.13	TSLP IL5 IL4 IL33 IL13 IL10
15	OX40 Pathway ⁶³	11.04	IL5 IL4 IL13 IL10
16	Cytokines and Inflammatory Response ¹	11.02	IL5 IL4 IL13 IL10 CD4
17	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	10.66	IL5 IL4 IL13

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GO Terms for Legume Allergy

Cellular components related to Legume Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.76	TSLP TNXB IL5 IL4 IL33 IL13
2	extracellular region	GO:0005576	9.61	TSLP TNXB IL5 IL4 IL33 IL13
3	external side of plasma membrane	GO:0009897	9.02	IL13 ICOSLG ENPP3 CD4 CCR6

Biological processes related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.8	IL5 IL4 IL13 IL10 CD4
2	immune response	GO:0006955	9.8	IL5 IL4 IL13 IL10 CD4 CCR6
3	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.73	TSLP IL4 IL13
4	positive regulation of B cell proliferation	GO:0030890	9.65	IL5 IL4 IL13
5	negative regulation of endothelial cell apoptotic process	GO:2000352	9.63	IL4 IL13 IL10
6	macrophage activation	GO:0042116	9.61	IL4 IL13
7	positive regulation of immunoglobulin secretion	GO:0051024	9.6	IL5 IL33
8	positive regulation of interleukin-10 secretion	GO:2001181	9.59	IL4 IL13
9	positive regulation of mast cell degranulation	GO:0043306	9.58	IL4 IL13
10	negative regulation of tumor necrosis factor biosynthetic process	GO:0042536	9.58	IL4 IL10
11	positive regulation of MHC class II biosynthetic process	GO:0045348	9.57	IL4 IL10
12	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.55	IL4 FOXP3
13	negative regulation of inflammatory response	GO:0050728	9.55	IL4 IL13 IL10 FOXP3 ENPP3
14	positive regulation of interleukin-5 production	GO:0032754	9.54	TSLP IL33
15	negative regulation of interferon-gamma production	GO:0032689	9.54	IL33 IL10 FOXP3
16	type 2 immune response	GO:0042092	9.52	IL4 IL10
17	regulation of isotype switching	GO:0045191	9.51	IL4 IL10
18	negative regulation of chronic inflammatory response	GO:0002677	9.49	IL4 FOXP3
19	negative regulation of complement-dependent cytotoxicity	GO:1903660	9.43	IL4 IL13
20	positive regulation of macrophage activation	GO:0043032	9.43	IL33 IL13 IL10
21	T cell activation	GO:0042110	9.26	IL4 ICOSLG FOXP3 CD4
22	positive regulation of interleukin-13 production	GO:0032736	8.8	TSLP IL4 IL33

Molecular functions related to Legume Allergy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.1	TSLP IL5 IL4 IL33 IL13 IL10

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Sources for Legume Allergy

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⁷⁴ Wikipedia