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MCID: LGM010
MIFTS: 29

Legume Allergy

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Legume Allergy

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MalaCards integrated aliases for Legume Allergy:

Name: Legume Allergy 12 15
Fabaceae Allergy 12

Classifications:

MalaCards categories:
Anatomical: Immune diseases
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External Ids:

Disease Ontology 12 DOID:0060904
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Summaries for Legume Allergy

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Disease Ontology : 12 A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product.

MalaCards based summary : Legume Allergy, also known as fabaceae allergy, is related to peanut allergy and exercise-induced anaphylaxis. An important gene associated with Legume Allergy is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Legume Allergy

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Diseases related to Legume Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 peanut allergy 31.3 PEDS1 LCOR IL5 IL4 IL13 IL10
2 exercise-induced anaphylaxis 30.5 FLG ENPP3
3 food allergy 29.2 SCP2 IL5 IL4 IL13 IL10 FOXP3
4 rhinitis 29.0 TSLP IL5 IL4 IL33 IL13 IL10
5 cytokine deficiency 10.4 IL5 IL13
6 aztreonam allergy 10.4 IL5 IL13
7 cefuroxime allergy 10.4 IL5 IL13
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL13
9 respiratory syncytial virus infectious disease 10.4 IL5 IL13
10 acute asthma 10.4 IL5 IL4
11 rocuronium allergy 10.3 PEDS1 CD63
12 carbapenem allergy 10.3 IL13 ENPP3
13 atopic keratoconjunctivitis 10.3 IL5 IL4
14 aneruptive fever 10.3 IL13 FOXP3
15 tropical endomyocardial fibrosis 10.3 IL4 IL10
16 scleritis 10.3 IL5 IL4 CCR6
17 pemphigoid 10.3 IL5 IL4 IL13
18 kimura disease 10.3 IL5 IL4 IL13
19 vernal keratoconjunctivitis 10.3 IL5 IL4 IL13
20 angiostrongyliasis 10.3 IL5 IL4 IL13
21 amoxicillin allergy 10.3 ENPP3 CD63
22 onchocerciasis 10.3 IL5 IL4 IL13
23 pulmonary eosinophilia 10.3 IL5 IL4 IL13
24 irritant dermatitis 10.3 TSLP IL4 FLG
25 chlorhexidine allergy 10.3 ENPP3 CD63
26 cefaclor allergy 10.3 IL5 IL13 CD63
27 acute gonococcal cervicitis 10.3 IL4 IL10
28 psoriasis 15 10.3 TSLP IL4 IL13
29 chronic inducible urticaria 10.2 TSLP IL5 ENPP3
30 ceftriaxone allergy 10.2 IL5 IL13 IL10
31 oxirane allergy 10.2 ENPP3 CD63
32 eosinophilic gastritis 10.2 IL5 IL13
33 toxic oil syndrome 10.2 IL5 IL4
34 diclofenac allergy 10.2 ENPP3 CD63
35 orofacial granulomatosis 10.2 IL4 IL10 FLG
36 dermatographia 10.2 ENPP3 CD63 CCR6
37 inflammatory bowel disease 18 10.2 IL4 IL10 CCR6
38 cardiomyopathy, familial hypertrophic, 20 10.2 IL5 IL13 IL10
39 cow milk allergy 10.2 IL5 IL4 IL10
40 crab allergy 10.2 IL5 ENPP3 CD63
41 endomyocardial fibrosis 10.2 IL5 IL4 IL10
42 norwegian scabies 10.2 IL5 CD4
43 chlamydia 10.2 IL5 IL4 IL10
44 autoimmune gastritis 10.2 IL4 IL10 CCR6
45 latex allergy 10.2 IL5 IL4 IL13 FLG
46 suppurative lymphadenitis 10.2 CD4 CCR6
47 immunodeficiency 35 10.2 IL10 ICOSLG CCR6
48 severe combined immunodeficiency, x-linked 10.2 TSLP IL4 IL13
49 transient arthritis 10.2 FLG CD4
50 seborrheic dermatitis 10.2 FLG CD4 CCR6

Graphical network of the top 20 diseases related to Legume Allergy:



Diseases related to Legume Allergy
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Symptoms & Phenotypes for Legume Allergy

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MGI Mouse Phenotypes related to Legume Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCR6 CD4 COPS7A ENPP3 FOXP3 IL10
2 homeostasis/metabolism MP:0005376 10.03 CCR6 CD4 CD63 COPS7A FOXP3 IL10
3 digestive/alimentary MP:0005381 10.02 CD4 CD63 ENPP3 FOXP3 IL10 IL13
4 immune system MP:0005387 9.73 CCR6 CD4 COPS7A ENPP3 FOXP3 IL10
5 respiratory system MP:0005388 9.23 ENPP3 FOXP3 IL10 IL13 IL33 IL4
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Drugs & Therapeutics for Legume Allergy

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Search Clinical Trials , NIH Clinical Center for Legume Allergy

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Genetic Tests for Legume Allergy

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Anatomical Context for Legume Allergy

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MalaCards organs/tissues related to Legume Allergy:

40
Kidney
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Publications for Legume Allergy

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Articles related to Legume Allergy:

(show all 18)
# Title Authors PMID Year
1
Adult and Pediatric Food Allergy to Chickpea, Pea, Lentil, and Lupine: A Scoping Review. 61
33166732 2021
2
Occupational airborne contact urticaria, anaphylaxis and asthma in farmers and agronomists due to Bruchus pisorum. 61
32592184 2020
3
Is it necessary to avoid all legumes in legume allergy? 61
32408382 2020
4
Propofol use in children with allergies to egg, peanut, soybean or other legumes. 61
31077340 2019
5
Cross-reactivity of a new food ingredient, dun pea, with legumes, and risk of anaphylaxis in legume allergic children. 61
26159477 2015
6
Grain and legume allergy. 61
26022874 2015
7
Variably severe systemic allergic reactions after consuming foods with unlabelled lupin flour: a case series. 61
24529316 2014
8
A comprehensive review of legume allergy. 61
22555630 2013
9
Anaphylactic reactions in mice with Fenugreek allergy. 61
21645030 2011
10
Molecular diagnosis of peanut and legume allergy. 61
21464707 2011
11
Kidney bean: a major sensitizer among legumes in asthma and rhinitis patients from India. 61
22096535 2011
12
Lupine, a source of new as well as hidden food allergens. 61
20013885 2010
13
Clinical features of legume allergy in children from a Mediterranean area. 61
18727474 2008
14
Soy allergy in perspective. 61
18560305 2008
15
Prevalence of legume sensitization in patients with naso-bronchial allergy. 61
18618316 2008
16
In vitro and in vivo cross-reactivity studies of legume allergy in a Mediterranean population. 61
18594152 2008
17
[Legume cross-reactivity]. 61
12783766 2003
18
Cross-allergenicity in the legume botanical family in children with food hypersensitivity. 61
2918186 1989
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Variations for Legume Allergy

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Expression for Legume Allergy

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Search GEO for disease gene expression data for Legume Allergy.
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Pathways for Legume Allergy

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Pathways related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Allograft rejection 36 1
Show member pathways
 12.69 IL5 IL4 IL13 IL10 ICOSLG FOXP3
2
Th17 cell differentiation 36
Show member pathways
 12.47 IL5 IL4 IL13 IL10 FOXP3 CD4
3
NF-kappaB Signaling 4
12.42 IL4 IL10 FOXP3 ENPP3 CD63
4
JAK-STAT signaling pathway 36
Show member pathways
 12.27 TSLP IL5 IL4 IL13 IL10
5
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.86 IL5 IL4 IL10 CD4
6
Hematopoietic cell lineage 36
11.75 IL5 IL4 CD4
7
Glucocorticoid receptor regulatory network 1
11.66 IL5 IL4 IL13
8
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.61 IL5 IL4 FOXP3
9
Lung fibrosis 1
11.52 IL5 IL4 IL13
10
IL4-mediated signaling events 1
11.51 IL5 IL4 IL10
11
IgA-Producing B Cells in the Intestine 64
11.45 IL5 IL4 IL10 ICOSLG FOXP3 CCR6
12
Interleukin-10 signaling 65
11.39 IL4 IL13 IL10
13
Development and heterogeneity of the ILC family 1
11.22 TSLP IL5 IL4 IL33 IL13
14
Th2 Differentiation Pathway 64
11.16 IL5 IL4 IL33 IL13 IL10 FOXP3
15
Innate Lymphoid Cell Differentiation Pathways 64
11.13 TSLP IL5 IL4 IL33 IL13 IL10
16
Cytokines and Inflammatory Response 1
11.12 IL5 IL4 IL13 IL10 CD4
17
OX40 Pathway 63
11.08 IL5 IL4 IL13 IL10
18
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.69 IL5 IL4 IL13
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GO Terms for Legume Allergy

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Cellular components related to Legume Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 IL13 ICOSLG ENPP3 CD4 CCR6

Biological processes related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.89 IL5 IL4 IL13 IL10 CD4
2 immune response GO:0006955 9.88 IL5 IL4 IL13 IL10 CD4 CCR6
3 negative regulation of tumor necrosis factor production GO:0032720 9.77 IL4 IL10 FOXP3
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 TSLP IL4 IL13
5 negative regulation of interferon-gamma production GO:0032689 9.72 IL33 IL10 FOXP3
6 positive regulation of B cell proliferation GO:0030890 9.71 IL5 IL4 IL13
7 positive regulation of interleukin-10 production GO:0032733 9.7 TSLP IL4 IL13
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 IL4 IL13 IL10
9 macrophage activation GO:0042116 9.61 IL4 IL13
10 positive regulation of interleukin-5 production GO:0032754 9.6 TSLP IL33
11 negative regulation of T-helper 17 cell differentiation GO:2000320 9.58 IL4 FOXP3
12 positive regulation of mast cell degranulation GO:0043306 9.57 IL4 IL13
13 type 2 immune response GO:0042092 9.56 IL4 IL10
14 negative regulation of inflammatory response GO:0050728 9.55 IL4 IL13 IL10 FOXP3 ENPP3
15 positive regulation of macrophage activation GO:0043032 9.54 IL33 IL13 IL10
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.5 IL4 IL33 IL10
17 negative regulation of complement-dependent cytotoxicity GO:1903660 9.48 IL4 IL13
18 regulation of isotype switching GO:0045191 9.46 IL4 IL10
19 negative regulation of chronic inflammatory response GO:0002677 9.43 IL4 FOXP3
20 positive regulation of interleukin-13 production GO:0032736 9.43 TSLP IL4 IL33
21 T cell activation GO:0042110 9.26 IL4 ICOSLG FOXP3 CD4
22 positive regulation of immunoglobulin production GO:0002639 8.92 IL5 IL33 IL13 IL10

Molecular functions related to Legume Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TSLP IL5 IL4 IL33 IL13 IL10
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Sources for Legume Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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