MCID: LGM010
MIFTS: 29

Legume Allergy

Categories: Immune diseases

Aliases & Classifications for Legume Allergy

MalaCards integrated aliases for Legume Allergy:

Name: Legume Allergy 12 15
Fabaceae Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060904

Summaries for Legume Allergy

Disease Ontology : 12 A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product.

MalaCards based summary : Legume Allergy, also known as fabaceae allergy, is related to peanut allergy and exercise-induced anaphylaxis. An important gene associated with Legume Allergy is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. Affiliated tissues include kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Legume Allergy

Diseases related to Legume Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)
# Related Disease Score Top Affiliating Genes
1 peanut allergy 31.5 PEDS1 PDCL LCOR IL5 IL4 IL13
2 exercise-induced anaphylaxis 30.7 FLG ENPP3
3 food allergy 29.0 SCP2 IL5 IL4 IL13 IL10 FOXP3
4 rhinitis 28.8 TSLP IL5 IL4 IL33 IL13 IL10
5 allergic hypersensitivity disease 28.2 TSLP PEDS1 IL5 IL4 IL33 IL13
6 cytokine deficiency 10.6 IL5 IL13
7 rocuronium allergy 10.5 PEDS1 CD63
8 timothy grass allergy 10.5 PEDS1 PDCL
9 aztreonam allergy 10.5 IL5 IL13
10 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 IL13
11 respiratory syncytial virus infectious disease 10.5 IL5 IL13
12 cefuroxime allergy 10.5 IL5 IL13
13 dermatitis, atopic, 3 10.5 TSLP FLG
14 ceftriaxone allergy 10.5 PEDS1 IL5 IL13
15 aneruptive fever 10.5 IL13 FOXP3
16 scleritis 10.4 IL5 IL4 CCR6
17 atopic keratoconjunctivitis 10.4 IL5 IL4
18 cough variant asthma 10.4 IL5 IL4 IL13
19 tropical endomyocardial fibrosis 10.4 IL4 IL10
20 vernal keratoconjunctivitis 10.4 IL5 IL4 IL13
21 angiostrongyliasis 10.4 IL5 IL4 IL13
22 fish allergy 10.4 PEDS1 PDCL
23 cefaclor allergy 10.4 IL5 IL13 CD63
24 apricot allergy 10.4 PEDS1 ENPP3
25 irritant dermatitis 10.4 TSLP IL4 FLG
26 peach allergy 10.4 SCP2 PEDS1 PDCL
27 erythema multiforme 10.4 IL5 IL4 IL13
28 onchocerciasis 10.4 IL5 IL4 IL13
29 chlorhexidine allergy 10.4 PEDS1 ENPP3
30 seborrheic dermatitis 10.4 FLG CD4 CCR6
31 orange allergy 10.3 SCP2 PDCL IL5
32 transient arthritis 10.3 FLG CD4
33 caplan's syndrome 10.3 FOXP3 CD4
34 acute proliferative glomerulonephritis 10.3 ICOSLG CD4 CCR6
35 autoimmune glomerulonephritis 10.3 ICOSLG CD4 CCR6
36 autoimmune disease of urogenital tract 10.3 ICOSLG CD4 CCR6
37 norwegian scabies 10.3 IL5 CD4
38 childhood type dermatomyositis 10.3 ICOSLG CD4 CCR6
39 chronic meningitis 10.3 IL5 IL13 CD4
40 sialadenitis 10.3 ICOSLG CD4 CCR6
41 autoimmune vasculitis 10.3 IL4 CD4 CCR6
42 strongyloidiasis 10.3 IL5 IL13 CD4
43 immunoglobulin alpha deficiency 10.3 ICOSLG CD4 CCR6
44 t cell deficiency 10.3 ICOSLG CD4 CCR6
45 carbapenem allergy 10.3 IL13 ENPP3
46 autoimmune disease of cardiovascular system 10.3 ICOSLG CD4 CCR6
47 keratoconjunctivitis sicca 10.3 IL4 CD4 CCR6
48 blepharitis 10.3 IL4 CD4 CCR6
49 neurodermatitis 10.3 IL4 FLG
50 severe combined immunodeficiency, x-linked 10.3 TSLP IL4 IL13

Graphical network of the top 20 diseases related to Legume Allergy:



Diseases related to Legume Allergy

Symptoms & Phenotypes for Legume Allergy

MGI Mouse Phenotypes related to Legume Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CCR6 CD4 COPS7A ENPP3 FOXP3 IL10
2 homeostasis/metabolism MP:0005376 10.03 CCR6 CD4 CD63 COPS7A FOXP3 IL10
3 digestive/alimentary MP:0005381 10.02 CD4 CD63 ENPP3 FOXP3 IL10 IL13
4 immune system MP:0005387 9.8 CCR6 CD4 COPS7A ENPP3 FOXP3 IL10
5 respiratory system MP:0005388 9.23 ENPP3 FOXP3 IL10 IL13 IL33 IL4

Drugs & Therapeutics for Legume Allergy

Search Clinical Trials , NIH Clinical Center for Legume Allergy

Genetic Tests for Legume Allergy

Anatomical Context for Legume Allergy

MalaCards organs/tissues related to Legume Allergy:

40
Kidney

Publications for Legume Allergy

Articles related to Legume Allergy:

(show all 16)
# Title Authors PMID Year
1
Is it necessary to avoid all legumes in legume allergy? 61
32408382 2020
2
Propofol use in children with allergies to egg, peanut, soybean or other legumes. 61
31077340 2019
3
Cross-reactivity of a new food ingredient, dun pea, with legumes, and risk of anaphylaxis in legume allergic children. 61
26159477 2015
4
Grain and legume allergy. 61
26022874 2015
5
Variably severe systemic allergic reactions after consuming foods with unlabelled lupin flour: a case series. 61
24529316 2014
6
A comprehensive review of legume allergy. 61
22555630 2013
7
Anaphylactic reactions in mice with Fenugreek allergy. 61
21645030 2011
8
Molecular diagnosis of peanut and legume allergy. 61
21464707 2011
9
Kidney bean: a major sensitizer among legumes in asthma and rhinitis patients from India. 61
22096535 2011
10
Lupine, a source of new as well as hidden food allergens. 61
20013885 2010
11
Clinical features of legume allergy in children from a Mediterranean area. 61
18727474 2008
12
Soy allergy in perspective. 61
18560305 2008
13
Prevalence of legume sensitization in patients with naso-bronchial allergy. 61
18618316 2008
14
In vitro and in vivo cross-reactivity studies of legume allergy in a Mediterranean population. 61
18594152 2008
15
[Legume cross-reactivity]. 61
12783766 2003
16
Cross-allergenicity in the legume botanical family in children with food hypersensitivity. 61
2918186 1989

Variations for Legume Allergy

Expression for Legume Allergy

Search GEO for disease gene expression data for Legume Allergy.

Pathways for Legume Allergy

Pathways related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 IL5 IL4 IL13 IL10 ICOSLG FOXP3
2
Show member pathways
12.45 IL5 IL4 IL13 IL10 FOXP3 CD4
3 12.39 IL4 IL10 FOXP3 ENPP3 CD63
4
Show member pathways
12.29 TSLP IL5 IL4 IL13 IL10
5 11.82 IL5 IL4 IL10 CD4
6 11.74 IL5 IL4 CD4
7 11.65 IL5 IL4 IL13
8
Show member pathways
11.6 IL5 IL4 FOXP3
9 11.51 IL5 IL4 IL13
10 11.5 IL5 IL4 IL10
11 11.38 IL4 IL13 IL10
12 11.16 TSLP IL5 IL4 IL33 IL13
13 11.16 IL5 IL4 IL33 IL13 IL10 FOXP3
14 11.13 TSLP IL5 IL4 IL33 IL13 IL10
15 11.04 IL5 IL4 IL13 IL10
16 11.02 IL5 IL4 IL13 IL10 CD4
17 10.66 IL5 IL4 IL13

GO Terms for Legume Allergy

Cellular components related to Legume Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 TSLP TNXB IL5 IL4 IL33 IL13
2 extracellular region GO:0005576 9.61 TSLP TNXB IL5 IL4 IL33 IL13
3 external side of plasma membrane GO:0009897 9.02 IL13 ICOSLG ENPP3 CD4 CCR6

Biological processes related to Legume Allergy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 IL5 IL4 IL13 IL10 CD4
2 immune response GO:0006955 9.8 IL5 IL4 IL13 IL10 CD4 CCR6
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TSLP IL4 IL13
4 positive regulation of B cell proliferation GO:0030890 9.65 IL5 IL4 IL13
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 IL4 IL13 IL10
6 macrophage activation GO:0042116 9.61 IL4 IL13
7 positive regulation of immunoglobulin secretion GO:0051024 9.6 IL5 IL33
8 positive regulation of interleukin-10 secretion GO:2001181 9.59 IL4 IL13
9 positive regulation of mast cell degranulation GO:0043306 9.58 IL4 IL13
10 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.58 IL4 IL10
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL4 IL10
12 negative regulation of T-helper 17 cell differentiation GO:2000320 9.55 IL4 FOXP3
13 negative regulation of inflammatory response GO:0050728 9.55 IL4 IL13 IL10 FOXP3 ENPP3
14 positive regulation of interleukin-5 production GO:0032754 9.54 TSLP IL33
15 negative regulation of interferon-gamma production GO:0032689 9.54 IL33 IL10 FOXP3
16 type 2 immune response GO:0042092 9.52 IL4 IL10
17 regulation of isotype switching GO:0045191 9.51 IL4 IL10
18 negative regulation of chronic inflammatory response GO:0002677 9.49 IL4 FOXP3
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
20 positive regulation of macrophage activation GO:0043032 9.43 IL33 IL13 IL10
21 T cell activation GO:0042110 9.26 IL4 ICOSLG FOXP3 CD4
22 positive regulation of interleukin-13 production GO:0032736 8.8 TSLP IL4 IL33

Molecular functions related to Legume Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TSLP IL5 IL4 IL33 IL13 IL10

Sources for Legume Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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