Aliases & Classifications for Leiomyoma

MalaCards integrated aliases for Leiomyoma:

Name: Leiomyoma 12 77 56 45 15
Leiomyomatous Neoplasm 12
Leiomyomatous Tumor 12
Uterine Fibroids 74
Fibroid Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:127
MeSH 45 D007889
NCIt 51 C3157
ICD10 34 D25.9

Summaries for Leiomyoma

Disease Ontology : 12 A cell type benign neoplasm that is a benign tumor of smooth muscle cells.

MalaCards based summary : Leiomyoma, also known as leiomyomatous neoplasm, is related to leiomyoma, uterine and bizarre leiomyoma, and has symptoms including pelvic pain An important gene associated with Leiomyoma is FH (Fumarate Hydratase), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Goserelin and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include uterus, breast and smooth muscle, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and cellular

Wikipedia : 77 A leiomyoma, also known as fibroids, is a benign smooth muscle tumor that very rarely becomes cancer... more...

Related Diseases for Leiomyoma

Diseases related to Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 473)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 34.4 ESR1 FH HMGA2 PGR RAD51B
2 bizarre leiomyoma 34.3 ACTC1 MED12 PGR
3 lung leiomyoma 34.0 ESR1 PGR
4 vulvar leiomyoma 34.0 ESR1 PGR
5 orbital leiomyoma 33.7 GNRH1 S100A1
6 benign metastasizing leiomyoma 33.7 ACTC1 CYP19A1 DES PGR
7 leiomyosarcoma 32.4 ACTC1 DES FH IGF2 MED12 PGR
8 gastrointestinal stromal tumor 32.0 ACTC1 CD34 DES IGF2 S100A1
9 leiomyomatosis 32.0 COL4A5 COL4A6 ESR1 FH GNRH1 MED12
10 intravenous leiomyomatosis 30.9 DES ESR1 MME
11 endometriosis 30.7 CYP19A1 ESR1 ESR2 GNRH1 PGR
12 lymphangioleiomyomatosis 30.7 DES ESR1 PGR
13 pleomorphic lipoma 30.7 HMGA2 PGR
14 mesenchymoma 30.6 DES HMGA2
15 adenomyosis 30.6 CYP19A1 ESR1 GNRH1 MME PGR
16 uterine sarcoma 30.4 CYP19A1 DES ESR1 MME
17 myoma 30.4 CYP19A1 ESR1 GNRH1 HMGA2 MED12 PGR
18 gynecomastia 30.4 CYP19A1 ESR1 PGR
19 liposarcoma 30.4 CD34 DES HMGA2
20 hemangiopericytoma, malignant 30.1 ACTC1 DES IGF2
21 cutaneous leiomyosarcoma 30.1 ACTC1 DES FH
22 endometriosis of ovary 30.1 CYP19A1 ESR1 ESR2 PGR
23 prostatic hypertrophy 30.1 CYP19A1 ESR1 PGR
24 diffuse peritoneal leiomyomatosis 30.0 CD34 ESR1 MED12 PGR
25 myxoid leiomyosarcoma 29.9 ACTC1 MME PGR
26 glomangiomyoma 29.9 ACTC1 CD34 ESR1
27 smooth muscle tumor 29.9 ACTC1 DES ESR1 HMGA2 MME PGR
28 small intestinal sarcoma 29.9 CD34 IGF2
29 dermatofibrosarcoma protuberans 29.8 ACTC1 CD34 DES
30 endometrial stromal sarcoma 29.8 ACTC1 CYP19A1 DES ESR1 MME PGR
31 endometrial cancer 29.8 CYP19A1 ESR1 ESR2 GNRH1 MME PGR
32 carcinosarcoma 29.8 ACTC1 DES MME PGR
33 breast disease 29.6 CYP19A1 ESR1 ESR2 IGF2 PGR
34 perivascular epithelioid cell tumor 29.6 ACTC1 DES MME PGR
35 cellular leiomyoma 12.4
36 deep leiomyoma 12.4
37 uterine corpus bizarre leiomyoma 12.3
38 leiomyoma cutis 12.2
39 hereditary leiomyomatosis and renal cell cancer 12.2
40 uterine corpus apoplectic leiomyoma 12.2
41 gastric leiomyoma 12.2
42 bladder leiomyoma 12.2
43 liver leiomyoma 12.2
44 prostate leiomyoma 12.2
45 gallbladder leiomyoma 12.2
46 ureter leiomyoma 12.2
47 urethra leiomyoma 12.1
48 colon leiomyoma 12.1
49 small intestine leiomyoma 12.1
50 appendix leiomyoma 12.1

Graphical network of the top 20 diseases related to Leiomyoma:



Diseases related to Leiomyoma

Symptoms & Phenotypes for Leiomyoma

UMLS symptoms related to Leiomyoma:


pelvic pain

GenomeRNAi Phenotypes related to Leiomyoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.02 ESR1 ESR2 FH IGF2 RAD51B

MGI Mouse Phenotypes related to Leiomyoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.23 ACTC1 CD34 CYP19A1 DES ESR1 ESR2
2 cardiovascular system MP:0005385 10.22 ACTC1 COL4A5 CYP19A1 DES ESR1 ESR2
3 homeostasis/metabolism MP:0005376 10.21 ACTC1 CD34 COL4A5 CYP19A1 DES ESR1
4 hematopoietic system MP:0005397 10.1 CD34 COL4A5 CYP19A1 ESR1 ESR2 GNRH1
5 immune system MP:0005387 10.06 CD34 COL4A5 CYP19A1 ESR1 ESR2 GNRH1
6 digestive/alimentary MP:0005381 9.98 CYP19A1 ESR1 ESR2 GNRH1 IGF2 IL17B
7 integument MP:0010771 9.91 CD34 CYP19A1 DPT ESR1 ESR2 GNRH1
8 muscle MP:0005369 9.76 ACTC1 CYP19A1 DES ESR1 ESR2 IGF2
9 normal MP:0002873 9.65 ACTC1 COL4A6 CYP19A1 ESR1 ESR2 GNRH1
10 renal/urinary system MP:0005367 9.17 COL4A5 CYP19A1 ESR1 ESR2 FH GNRH1

Drugs & Therapeutics for Leiomyoma

Drugs for Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 283)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 5311128 47725
2
Dienogest Approved Phase 4 65928-58-7
3
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
4
Desogestrel Approved Phase 4 54024-22-5 40973
5
Nandrolone phenpropionate Approved, Illicit, Investigational Phase 4 62-90-8 229455
6
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 53714-56-0 657181 3911
7
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
8
Dimenhydrinate Approved Phase 4 523-87-5 441281
9
Misoprostol Approved Phase 4,Phase 3,Phase 2 59122-46-2 5282381
10
Calcium Carbonate Approved, Investigational Phase 4,Phase 3 471-34-1
11
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1197-18-8 5526
12
Anastrozole Approved, Investigational Phase 4,Phase 3 120511-73-1 2187
13
Zinc Approved, Investigational Phase 4 7440-66-6 32051
14
leucovorin Approved Phase 4 58-05-9 143 6006
15
Ferrous fumarate Approved Phase 4 141-01-5
16
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
17
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
18
Methylcobalamin Approved, Experimental, Investigational Phase 4 13422-55-4
19
Zinc oxide Approved Phase 4 1314-13-2
20
Tocopherol Approved, Investigational Phase 4 1406-66-2 14986
21
Letrozole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 112809-51-5 3902
22
Cetrorelix Approved, Investigational Phase 4 120287-85-6 25074887 16129715
23
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
24
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 137-58-6 3676
25
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
26
Acetaminophen Approved Phase 4 103-90-2 1983
27
Ibuprofen Approved Phase 4,Not Applicable 15687-27-1 3672
28
Morphine Approved, Investigational Phase 4 57-27-2 5288826
29
Prilocaine Approved Phase 4 721-50-6 4906
30
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
31
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
32
Dinoprostone Approved Phase 4,Not Applicable 363-24-6 5280360
33
Mifepristone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 84371-65-3 55245
34
Levonorgestrel Approved, Investigational Phase 4,Phase 2,Not Applicable 797-63-7, 17489-40-6 13109
35
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 57-83-0 5994
36
Oxytocin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-56-6 53477758 439302
37
tannic acid Approved Phase 4,Not Applicable 1401-55-4
38
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
39
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Not Applicable 1177-87-3
40
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
41
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 5284616 6436030
42
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
43
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
44
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
45
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
46
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
47
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
48
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 56-40-6 750
49
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6, 59-43-8 1130
50
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054

Interventional clinical trials:

(show top 50) (show all 382)
# Name Status NCT ID Phase Drugs
1 Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
2 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Unknown status NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate
3 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Unknown status NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
4 High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids Unknown status NCT01239641 Phase 4
5 Ulipristal Acetate Versus GnRH Analogue and Myometrial Preservation Unknown status NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
6 IVF Outcome Following Treatment With Ulipristal Acetate for Myomatous Uterus After at Least One IVF Failure Unknown status NCT02601196 Phase 4 Ulipristal acetate
7 Ulipristal vs. GnRHa Prior to Laparoscopic Myomectomy Unknown status NCT02288130 Phase 4 GnRHa;Ulipristal
8 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Unknown status NCT02440750 Phase 4 Dienogest;Ulipristal acetate
9 The Effect of Ulipristal Acetate (UPA) on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate
10 Seprafilm Slurry in the Prevention of Uterine Scarring in Patients Undergoing Hysteroscopic Myomectomy Unknown status NCT01632202 Phase 4
11 Vaginal Misoprostol Versus Bilateral Uterine Artery Ligation in Decreasing Blood Loss in Trans-abdominal Myomectomy Unknown status NCT02643186 Phase 4 preoperative vaginal misoprostol
12 Fibroids in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4 Dydrogesterone M ( case 1 );Dydrogesterone M ( case 2 )
13 Pilot of Letrozole for Uterine Myomas Completed NCT02470741 Phase 4 Letrozole
14 Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids Completed NCT00746031 Phase 4 GnRH analogue (Zoladex);GnRH antagonist-Cetrorelix
15 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
16 The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. Completed NCT00995878 Phase 4
17 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization Completed NCT02293447 Phase 4 Lidocaine per-embolization;Lidocaine post-embolization
18 Efficacy Study of Magnetic Resonance (MR) Guided Focused Ultrasound in the Treatment of Large Fibroids Completed NCT00159328 Phase 4
19 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;Intravenous placebo/Intravenous placebo
20 Randomized Controlled Trial (RCT)Comparing GYNAECARE MORCELLEX Versus ROTOCUT GI Tissue Morcellators Completed NCT00743080 Phase 4
21 Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery Completed NCT01388907 Phase 4
22 Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial Completed NCT01393704 Phase 4 Vasopressin
23 Ambulatory Oxygen in Fibrotic Lung Disease (FLD) (AmbOx) Completed NCT02286063 Phase 4 Ambulatory Oxygen
24 Intravenous or Intra-abdominal Local Anesthetics for Postoperative Pain Management. Completed NCT01492179 Phase 4 Normal saline;Intravenous Lidocaine;Intra-abdominal Lidocaine
25 Comparing Two Types of Sedation to Gynaecological Patients Completed NCT01412632 Phase 4 Remifentanil, propofol and citanest
26 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy Completed NCT02154932 Phase 4 2 doses 400 microgram misoprostol;single dose misoprostol
27 Understanding Experimentally Induced Hot Flushes Completed NCT00455689 Phase 4 Leuprolide acetate
28 Impact of Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
29 A Study on the Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy Recruiting NCT03210324 Phase 4 Mifepristone tablets
30 Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis Recruiting NCT03500367 Phase 4 rapamycin
31 Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Recruiting NCT03317795 Phase 4 Levonorgestrel IUS;Tranexamic Acid
32 Misoprostol for Reduction of Blood Loss During Fibroid Surgery Recruiting NCT02209545 Phase 4 Misoprostol;Placebo
33 Aromatase Plus GnRH Analogue Versus Ulippristal Acetate in Uterine Fibroids Recruiting NCT03421639 Phase 4 Ulipristal acetate;Aromatase inhibitor plus GnRH analog
34 Combined Vaginal Misoprostol and Perivascular Vasopressin Recruiting NCT03815344 Phase 4 Standard;Standard-vaginal misoprostol
35 Ulipristal Use in Chinese Population Active, not recruiting NCT02825719 Phase 4 Ulipristal acetate;Ferrous sulphate;Tranexamic Acid
36 Oxytocin in MRI-HIFU Enrolling by invitation NCT03937401 Phase 4 Oxytocin
37 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
38 Intravenous Oxytocin Versus Tranexamic Acid in Reducing Blood Loss During Abdominal Myomectomy. Not yet recruiting NCT03892668 Phase 4 Tranexamic Acid;oxytocin;placebo
39 Safety Trial of Magnetic Resonance (MR) Guided Focused Ultrasound Surgery (FUS) in Women With Uterine Fibroids Wishing to Pursue Pregnancy in the Future Terminated NCT00180739 Phase 4
40 Preemptive Analgesia Following Uterine Artery Embolization Terminated NCT01555073 Phase 4 pregabalin/celecoxib;pregabalin/placebo;celecoxib/placebo;Placebo group
41 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
42 Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis Withdrawn NCT03325868 Phase 4 Ulipristal Acetate
43 Study of Tumor-shrinking Decoction (TSD) to Treat Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3 TSD
44 Influence of Aromatase Inhibitors and GnRH Analogs to Treat Uterine Leiomyoma by Vaginal Hysterectomy Unknown status NCT01280045 Phase 3
45 Clinical Trial of Uterine Artery Embolization for Uterine Leiomyoma Unknown status NCT00821275 Phase 2, Phase 3
46 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
47 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
48 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
49 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3 Ramosetron
50 Hemostatic Effect of Intrauterine Instillation Of Tranexamic Acid In Hysteroscopic Myomectomy Unknown status NCT03122782 Phase 3 Topical application Tranexamic acid;Placebo (Normal saline)

Search NIH Clinical Center for Leiomyoma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: leiomyoma

Genetic Tests for Leiomyoma

Anatomical Context for Leiomyoma

MalaCards organs/tissues related to Leiomyoma:

42
Uterus, Breast, Smooth Muscle, Prostate, Lung, Kidney, Ovary

Publications for Leiomyoma

Articles related to Leiomyoma:

(show top 50) (show all 3485)
# Title Authors Year
1
Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature. ( 30989050 )
2019
2
Benign Metastasizing Leiomyoma to the Lung and Spine: A Case Report and Literature Review. ( 31011319 )
2019
3
Multisystemic Benign Metastasizing Leiomyoma: An Unusual Condition with an Atypical Clinical Presentation. ( 31093407 )
2019
4
Transurethral Enucleation of Bladder Leiomyoma: A Series of Six Cases and Review of the Literature. ( 30227443 )
2019
5
Partial cystectomy in young male for a urachal tumor masquerading a bladder leiomyoma. ( 30932431 )
2019
6
Primary non-gestational uterine choriocarcinoma mimicking leiomyoma. ( 30775828 )
2019
7
Coexistence of a Tubal Ectopic Pregnancy and Tubal Leiomyoma. ( 29704678 )
2019
8
Benign metastasising leiomyoma with lymph node metastases in a patient with endometrial cancer after caesarean section. ( 30257590 )
2019
9
Hypoxia Induces Hypoxia-Inducible Factor 1α and Potential HIF-Responsive Gene Expression in Uterine Leiomyoma. ( 29779471 )
2019
10
Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma. ( 30538295 )
2019
11
Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways. ( 30615907 )
2019
12
Hydropic leiomyoma presenting as a rare condition of pseudo-Meigs syndrome: literature review and a case of a pseudo-Meigs syndrome mimicking ovarian carcinoma with elevated CA125. ( 30635302 )
2019
13
Caudocranial Scanning to Evaluate Bilateral Ovarian Arteries Supplying a Uterine Leiomyoma. ( 30635460 )
2019
14
Skull base angiomatous leiomyoma: a case report and review of literature. ( 30636462 )
2019
15
Suspected Hypercalcemia of Benignancy Associated with Canine Vaginal Leiomyoma. ( 30653358 )
2019
16
Susceptibility weighted MRI after uterine artery embolization for leiomyoma. ( 30654161 )
2019
17
Two cases of acute urinary retention caused by large cervical leiomyoma with review of literature. ( 30658025 )
2019
18
Nipple leiomyoma: A rare neoplasm with a broad spectrum of histologic appearances. ( 30663114 )
2019
19
Successful en bloc endoscopic full-thickness resection of a giant cervical esophageal leiomyoma originating from muscularis propria. ( 30665433 )
2019
20
Sudden rupture with internal bleeding and shock following torsion and necrosis of a large uterine leiomyoma. ( 30712455 )
2019
21
Interactome Analysis Of The Differentially Expressed Proteins In Uterine Leiomyoma. ( 30727917 )
2019
22
A Case of Hemoperitoneum Due to Spontaneous Bleeding from a Uterine Leiomyoma. ( 30733430 )
2019
23
Laparoscopic management of a large urethral leiomyoma. ( 30756139 )
2019
24
Torsion of a uterine leiomyoma - a rare cause of hemoperitoneum; a case report and review of the literature. ( 30779835 )
2019
25
A Benign Uterine Leiomyoma with Disturbing Appearance. ( 30783590 )
2019
26
A rare anal mass: anal leiomyoma presented as perianal fistula. ( 30792839 )
2019
27
Leiomyoma of the Foot: A Case Report and Literature Review. ( 30803909 )
2019
28
Cystic lung lesions mimicking hydatidosis: hamartoma or benign metastazing leiomyoma? ( 30825451 )
2019
29
Magnetic Resonance and Intraoperative Imaging of a Periurethral Leiomyoma. ( 30826450 )
2019
30
The Autonomic Innervation and Uterine Telocyte Interplay in Leiomyoma Formation. ( 30841718 )
2019
31
New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System. ( 30842391 )
2019
32
Preoperative Differentiation of Uterine Sarcoma from Leiomyoma: Comparison of Three Models Based on Different Segmentation Volumes Using Radiomics. ( 30850967 )
2019
33
Intravascular (post-hysterectomy) leiomyoma (IVL) as late tumor thrombus within the inferior vena cava (IVC)-A rare case primarily imposing as IVC thrombus originating from left renal vein after former left nephrectomy status. ( 30853174 )
2019
34
Unique case of 'trigger wrist' secondary to deep tissue leiomyoma in a healthy 6-year-old. ( 30861629 )
2019
35
Ulipristal acetate decreases active TGF-β3 and its canonical signaling in uterine leiomyoma via two novel mechanisms. ( 30871768 )
2019
36
Nasopharyngeal Leiomyoma. ( 30885006 )
2019
37
MR imaging of paratesticular bilateral leiomyoma: A case report. ( 30891109 )
2019
38
Ectopic leiomyoma as a late complication of laparoscopic hysterectomy with power morcellation: a case report and review of the literature. ( 30892129 )
2019
39
Leiomyoma of the External Auditory Canal. ( 30924774 )
2019
40
Racial Disparities in Response to a US Food and Drug Administration Safety Communication Regarding the Use of Power Morcellation for the Treatment of Uterine Leiomyoma. ( 30936031 )
2019
41
Clinical Outcomes of Minimally Invasive Enucleation of Leiomyoma of the Esophagus and Esophagogastric Junction. ( 30941689 )
2019
42
Insufficient Leiomyoma Infarction in Uterine Artery Embolization: Relationship with Tumor Location. ( 30952521 )
2019
43
Transcriptome Analysis of mRNA in Uterine Leiomyoma Using Next-Generation RNA Sequencing. ( 30963983 )
2019
44
Aberrant Hypermetabolism of Benign Uterine Leiomyoma on 18F-FDG PET/CT. ( 30985441 )
2019
45
Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma. ( 30989560 )
2019
46
Primary intracranial leiomyoma - A case report and literature review. ( 31000945 )
2019
47
Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) Hull Extract and Active Compounds Inhibit Proliferation of Primary Human Leiomyoma Cells and Protect against Sexual Hormone-Induced Mice Smooth Muscle Hyperproliferation. ( 31010220 )
2019
48
Bisphenol A promotes the proliferation of leiomyoma cells by GPR30-EGFR signaling pathway. ( 31016847 )
2019
49
Leiomyoma with KAT6B-KANSL1 fusion: case report of a rapidly enlarging uterine mass in a postmenopausal woman. ( 31027501 )
2019
50
Pleomorphic Undifferentiated Uterine Sarcoma in a Young Patient Presenting With Elevated Beta-hCG and Rare Variants of Benign Leiomyoma: A Case Report and Review of the Literature. ( 31033798 )
2019

Variations for Leiomyoma

Expression for Leiomyoma

Search GEO for disease gene expression data for Leiomyoma.

Pathways for Leiomyoma

GO Terms for Leiomyoma

Cellular components related to Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 ACTC1 COL4A5 COL4A6 DPT GNRH1 IGF2
2 collagen-containing extracellular matrix GO:0062023 9.56 COL4A5 COL4A6 DPT TGFB3
3 extracellular region GO:0005576 9.28 CD34 COL4A5 COL4A6 DPT GNRH1 IGF2
4 collagen type IV trimer GO:0005587 8.96 COL4A5 COL4A6

Biological processes related to Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 ESR1 ESR2 HMGA2 MED12 TGFB3
2 cell-cell signaling GO:0007267 9.62 ESR2 GNRH1 IL17B PGR
3 uterus development GO:0060065 9.46 CYP19A1 ESR1
4 androgen metabolic process GO:0008209 9.43 CYP19A1 ESR1
5 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.37 COL4A5 COL4A6
6 embryonic neurocranium morphogenesis GO:0048702 9.26 MED12 TGFB3
7 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 ESR1 ESR2 MED12 PGR
8 paracrine signaling GO:0038001 9.16 CD34 PGR
9 intracellular steroid hormone receptor signaling pathway GO:0030518 9.1 ESR1
10 mammary gland development GO:0030879 8.8 CYP19A1 PGR TGFB3

Molecular functions related to Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.54 ESR1 PGR S100A1
2 steroid hormone receptor activity GO:0003707 9.5 ESR1 ESR2 PGR
3 nuclear receptor activity GO:0004879 9.33 ESR1 ESR2 PGR
4 estrogen receptor activity GO:0030284 9.26 ESR1 ESR2
5 estrogen response element binding GO:0034056 8.96 ESR1 ESR2
6 steroid binding GO:0005496 8.8 ESR1 ESR2 PGR

Sources for Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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