MCID: LMY001
MIFTS: 30

Leiomyoma Cutis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Leiomyoma Cutis

MalaCards integrated aliases for Leiomyoma Cutis:

Name: Leiomyoma Cutis 12 15
Cutaneous Leiomyoma 12 29 6 73
Leiomyoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5132
NCIt 50 C4482
UMLS 73 C0346064

Summaries for Leiomyoma Cutis

MalaCards based summary : Leiomyoma Cutis, also known as cutaneous leiomyoma, is related to angiomyoma and hereditary leiomyomatosis and renal cell cancer. An important gene associated with Leiomyoma Cutis is FH (Fumarate Hydratase). The drugs Acetylcholine and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include skin and kidney.

Related Diseases for Leiomyoma Cutis

Diseases related to Leiomyoma Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 angiomyoma 29.7 CALD1 CLEC2A
2 hereditary leiomyomatosis and renal cell cancer 12.2
3 leiomyoma 10.6
4 leiomyomatosis 10.1
5 trigeminal nerve disease 10.1 TAC1 TRPV1
6 burning mouth syndrome 10.1 TAC1 TRPV1
7 mononeuropathy 10.1 TAC1 TRPV1
8 gastric leiomyoma 10.1 CALD1 FH
9 dental pulp disease 10.1 TAC1 TRPV1
10 aspiration pneumonia 10.1 TAC1 TRPV1
11 paine syndrome 10.1 TAC1 TRPV1
12 pain agnosia 10.1 TAC1 TRPV1
13 agnosia 10.1 TAC1 TRPV1
14 somatoform disorder 10.1 TAC1 TRPV1
15 interstitial cystitis 10.1 TAC1 TRPV1
16 cystitis 10.1 TAC1 TRPV1
17 irritable bowel syndrome 10.1 TAC1 TRPV1
18 bronchial disease 10.0 TAC1 TRPV1
19 autoimmune disease of central nervous system 10.0 ICAM1 TRPV1
20 specific developmental disorder 10.0 TAC1 TRPV1
21 renal cell carcinoma, nonpapillary 10.0
22 arteries, anomalies of 10.0 ICAM1 TRPV1
23 immune system disease 10.0 ICAM1 TRPV1
24 respiratory system disease 10.0 ICAM1 TRPV1
25 peripheral nervous system disease 10.0 TAC1 TRPV1
26 cardiovascular organ benign neoplasm 9.9 CALD1 TAC1 TRPV1
27 benign perivascular tumor 9.9 CALD1 TAC1 TRPV1
28 nasal cavity disease 9.9 ICAM1 TAC1 TRPV1
29 nose disease 9.9 ICAM1 TAC1 TRPV1
30 upper respiratory tract disease 9.9 ICAM1 TAC1 TRPV1
31 rhinitis 9.9 ICAM1 TRPV1
32 leiomyosarcoma 9.9
33 skin sarcoma 9.9 CALD1 CLEC2A FH
34 kidney cancer 9.8
35 intravenous leiomyomatosis 9.8
36 spitz nevus 9.8
37 inflammatory bowel disease 9.7 ICAM1 TAC1 TRPV1

Graphical network of the top 20 diseases related to Leiomyoma Cutis:



Diseases related to Leiomyoma Cutis

Symptoms & Phenotypes for Leiomyoma Cutis

Drugs & Therapeutics for Leiomyoma Cutis

Drugs for Leiomyoma Cutis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2 51-84-3 187
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 Botulinum Toxins, Type A Phase 2
4 Neurotransmitter Agents Phase 2
5 Cholinergic Agents Phase 2
6 abobotulinumtoxinA Phase 2
7 Neuromuscular Agents Phase 2
8 Peripheral Nervous System Agents Phase 2
9 Acetylcholine Release Inhibitors Phase 2
10 onabotulinumtoxinA Phase 2
11 Botulinum Toxins Phase 2
12 Protein Kinase Inhibitors Phase 2
13
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
14 Angiogenesis Modulating Agents Phase 2
15 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
2 A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer Recruiting NCT01130519 Phase 2 Bevacizumab;Erlotinib
3 Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer Recruiting NCT00050752

Search NIH Clinical Center for Leiomyoma Cutis

Genetic Tests for Leiomyoma Cutis

Genetic tests related to Leiomyoma Cutis:

# Genetic test Affiliating Genes
1 Cutaneous Leiomyoma 29

Anatomical Context for Leiomyoma Cutis

MalaCards organs/tissues related to Leiomyoma Cutis:

41
Skin, Kidney

Publications for Leiomyoma Cutis

Articles related to Leiomyoma Cutis:

(show all 43)
# Title Authors Year
1
Bilateral Multisegmental Zosteriform Leiomyoma Cutis: A Rare Entity. ( 26120160 )
2015
2
Leiomyoma cutis: a focused review on presentation, management, and association with malignancy. ( 25605645 )
2015
3
Desmoplastic Spitz Nevus Combined With Cutaneous Leiomyoma: A Rare Collision Tumor. ( 25171428 )
2014
4
Unusual presentation of cutaneous leiomyoma. ( 25484434 )
2014
5
Zosteriform cutaneous leiomyoma: a rare cutaneous neoplasm. ( 23930878 )
2013
6
Cutaneous leiomyoma in a child: A case report. ( 23599756 )
2013
7
Cutaneous leiomyoma: novel histologic findings for classification and diagnosis. ( 23456580 )
2013
8
Possible use of p53 in symplastic cutaneous leiomyoma. ( 21518385 )
2011
9
Leiomyoma cutis: a clinicopathological series of 37 cases. ( 21430885 )
2010
10
Solitary cutaneous leiomyoma in an infant. ( 19840329 )
2009
11
Hereditary multiple cutaneous leiomyoma resulting from novel mutations in the fumarate hydratase gene. ( 18514489 )
2008
12
Cutaneous leiomyoma with cytologic atypia, akin to uterine symplastic leiomyoma. ( 15355371 )
2004
13
Association of multiple familial cutaneous leiomyoma with a uterine symplastic leiomyoma. ( 10671972 )
2000
14
Zosteriform and disseminated lesions in cutaneous leiomyoma. ( 11243642 )
2000
15
Verocay body-prominent cutaneous leiomyoma. ( 10027539 )
1999
16
Multiple leiomyoma cutis associated with Becker's nevus. ( 8973041 )
1996
17
Cutaneous leiomyoma of the male nipple. ( 3979636 )
1985
18
Pathology quiz case 1: cutaneous leiomyoma (familial). ( 6508334 )
1984
19
Leiomyoma cutis. ( 6678281 )
1983
20
Leiomyoma cutis and leiomyosarcoma: a 10-year study and a short review. ( 6833615 )
1983
21
Muscle relaxing agent in cutaneous leiomyoma. ( 6873419 )
1983
22
Tumor conference #40: leiomyoma cutis of the cheek. ( 7061755 )
1982
23
Leiomyoma Cutis (A clinico-pathological review with a case report). ( 29139414 )
1973
24
Familial cutaneous leiomyoma. ( 4791221 )
1973
25
Segmentary and disseminated lesions in multiple hereditary cutaneous leiomyoma. ( 5115893 )
1971
26
Leiomyoma cutis: an electron microscope study. ( 5431552 )
1970
27
MULTIPLE CUTANEOUS LEIOMYOMA IN IDENTICAL TWINS. ( 14149729 )
1964
28
Leiomyoma cutis and its surgical treatment. ( 13974004 )
1962
29
Leiomyoma cutis. ( 13607906 )
1958
30
Cutaneous leiomyoma; classification and report of solitary angioleiomyoma. ( 13361514 )
1956
31
Leiomyoma cutis. ( 14789226 )
1951
32
Leiomyoma cutis. ( 15419829 )
1950
33
Leiomyoma cutis (zosteriform). ( 18135865 )
1949
34
Cutaneous leiomyoma of goldfish; morphology and growth in tissue culture. ( 18113084 )
1949
35
Leiomyoma Cutis. ( 19993516 )
1947
36
Leiomyoma cutis. ( 20251574 )
1947
37
Leiomyoma cutis. ( 20342296 )
1947
38
A case of leiomyoma cutis. ( 20287036 )
1946
39
Leiomyoma cutis. ( 20277331 )
1946
40
Leiomyoma Cutis. ( 19990680 )
1936
41
Leiomyoma Cutis. ( 19988170 )
1931
42
Leiomyoma Cutis Multiplex. ( 19987146 )
1929
43
Leiomyoma Cutis. ( 19985653 )
1927

Variations for Leiomyoma Cutis

ClinVar genetic disease variations for Leiomyoma Cutis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FH NM_000143.3(FH): c.322C> T (p.Gln108Ter) single nucleotide variant Pathogenic/Likely pathogenic rs1060499630 GRCh37 Chromosome 1, 241676959: 241676959
2 FH NM_000143.3(FH): c.322C> T (p.Gln108Ter) single nucleotide variant Pathogenic/Likely pathogenic rs1060499630 GRCh38 Chromosome 1, 241513659: 241513659

Expression for Leiomyoma Cutis

Search GEO for disease gene expression data for Leiomyoma Cutis.

Pathways for Leiomyoma Cutis

GO Terms for Leiomyoma Cutis

Cellular components related to Leiomyoma Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.1 CALD1 CLEC2A FXYD1 ICAM1 TAC1 TRPV1

Biological processes related to Leiomyoma Cutis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.4 ICAM1 TRPV1
2 muscle contraction GO:0006936 9.37 CALD1 FXYD1
3 sensory perception of pain GO:0019233 9.32 TAC1 TRPV1
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.26 ICAM1 TRPV1
5 cellular response to nerve growth factor stimulus GO:1990090 9.16 TAC1 TRPV1
6 response to pain GO:0048265 8.96 TAC1 TRPV1
7 cellular response to alkaloid GO:0071312 8.62 ICAM1 TRPV1

Sources for Leiomyoma Cutis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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