MCID: LMY001
MIFTS: 21

Leiomyoma Cutis

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Leiomyoma Cutis

MalaCards integrated aliases for Leiomyoma Cutis:

Name: Leiomyoma Cutis 12 15
Cutaneous Leiomyoma 12 29 6 73
Leiomyoma of the Skin 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5132
NCIt 50 C4482
SNOMED-CT 68 254767008
UMLS 73 C0346064

Summaries for Leiomyoma Cutis

MalaCards based summary : Leiomyoma Cutis, also known as cutaneous leiomyoma, is related to hereditary leiomyomatosis and renal cell cancer and leiomyoma. An important gene associated with Leiomyoma Cutis is FH (Fumarate Hydratase). The drugs Acetylcholine and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include skin.

Related Diseases for Leiomyoma Cutis

Diseases related to Leiomyoma Cutis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hereditary leiomyomatosis and renal cell cancer 12.1
2 leiomyoma 10.4
3 leiomyosarcoma 9.8
4 skin sarcoma 9.0 CLEC2A FH

Symptoms & Phenotypes for Leiomyoma Cutis

Drugs & Therapeutics for Leiomyoma Cutis

Drugs for Leiomyoma Cutis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 2 51-84-3 187
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 abobotulinumtoxinA Phase 2
4 Cholinergic Agents Phase 2
5 Neuromuscular Agents Phase 2
6 Neurotransmitter Agents Phase 2
7 onabotulinumtoxinA Phase 2
8 Peripheral Nervous System Agents Phase 2
9 Botulinum Toxins, Type A Phase 2
10 Botulinum Toxins Phase 2
11
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
12 Angiogenesis Inhibitors Phase 2
13 Angiogenesis Modulating Agents Phase 2
14 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Pilot Study for the Treatment of Cutaneous Leiomyomas With Botulinum Toxin Completed NCT00971620 Phase 2
2 A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer Recruiting NCT01130519 Phase 2 Bevacizumab;Erlotinib
3 Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer Recruiting NCT00050752

Search NIH Clinical Center for Leiomyoma Cutis

Genetic Tests for Leiomyoma Cutis

Genetic tests related to Leiomyoma Cutis:

# Genetic test Affiliating Genes
1 Cutaneous Leiomyoma 29

Anatomical Context for Leiomyoma Cutis

MalaCards organs/tissues related to Leiomyoma Cutis:

41
Skin

Publications for Leiomyoma Cutis

Articles related to Leiomyoma Cutis:

(show all 39)
# Title Authors Year
1
Immunohistochemical Characterization of Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) in Cutaneous Leiomyomas for Detection of Familial Cancer Syndromes. ( 28288038 )
2017
2
Treatment of cutaneous leiomyomas with 5% lidocaine patches in a patient with hereditary leiomyomatosis and renal cell cancer (Reed syndrome). ( 28884140 )
2017
3
Is Immunohistochemical Screening of Cutaneous Leiomyomas for the Early Detection of Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome Justified? ( 29053494 )
2017
4
Immunohistochemistry for 2-Succinocysteine (2SC) and Fumarate Hydratase (FH) in Cutaneous Leiomyomas May Aid in Identification of Patients With HLRCC (Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome). ( 26945337 )
2016
5
Bilateral Multisegmental Zosteriform Leiomyoma Cutis: A Rare Entity. ( 26120160 )
2015
6
Leiomyoma cutis: a focused review on presentation, management, and association with malignancy. ( 25605645 )
2015
7
Novel missense mutation in the FH gene in familial renal cell cancer patients lacking cutaneous leiomyomas. ( 24684806 )
2014
8
Desmoplastic Spitz Nevus Combined With Cutaneous Leiomyoma: A Rare Collision Tumor. ( 25171428 )
2014
9
Zosteriform cutaneous leiomyoma: a rare cutaneous neoplasm. ( 23930878 )
2013
10
Atypical pilar leiomyomatosis: an unusual presentation of multiple atypical cutaneous leiomyomas. ( 23550704 )
2013
11
Cutaneous leiomyoma in a child: A case report. ( 23599756 )
2013
12
Cutaneous leiomyoma: novel histologic findings for classification and diagnosis. ( 23456580 )
2013
13
Possible use of p53 in symplastic cutaneous leiomyoma. ( 21518385 )
2011
14
Leiomyoma cutis: a clinicopathological series of 37 cases. ( 21430885 )
2010
15
Hereditary multiple cutaneous leiomyoma resulting from novel mutations in the fumarate hydratase gene. ( 18514489 )
2008
16
Cutaneous leiomyomas: a clinical marker of risk for hereditary leiomyomatosis and renal cell cancer. ( 16948378 )
2006
17
Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer. ( 16029320 )
2005
18
Cutaneous leiomyomas lack estrogen and progesterone receptor immunoreactivity. ( 9138116 )
1997
19
Multiple leiomyoma cutis associated with Becker's nevus. ( 8973041 )
1996
20
Multiple cutaneous leiomyomas. Report of a case. ( 8284075 )
1993
21
Leiomyoma cutis. ( 6678281 )
1983
22
Leiomyoma cutis and leiomyosarcoma: a 10-year study and a short review. ( 6833615 )
1983
23
Tumor conference #40: leiomyoma cutis of the cheek. ( 7061755 )
1982
24
Leiomyoma Cutis (A clinico-pathological review with a case report). ( 29139414 )
1973
25
Leiomyoma cutis: an electron microscope study. ( 5431552 )
1970
26
Leiomyoma cutis and its surgical treatment. ( 13974004 )
1962
27
Leiomyoma cutis. ( 13607906 )
1958
28
Leiomyoma cutis. ( 14789226 )
1951
29
Leiomyoma cutis. ( 15419829 )
1950
30
Leiomyoma cutis (zosteriform). ( 18135865 )
1949
31
Leiomyoma Cutis. ( 19993516 )
1947
32
Leiomyoma cutis. ( 20251574 )
1947
33
Leiomyoma cutis. ( 20342296 )
1947
34
A case of leiomyoma cutis. ( 20287036 )
1946
35
Leiomyoma cutis. ( 20277331 )
1946
36
Leiomyoma Cutis. ( 19990680 )
1936
37
Leiomyoma Cutis. ( 19988170 )
1931
38
Leiomyoma Cutis Multiplex. ( 19987146 )
1929
39
Leiomyoma Cutis. ( 19985653 )
1927

Variations for Leiomyoma Cutis

ClinVar genetic disease variations for Leiomyoma Cutis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 FH NM_000143.3(FH): c.322C> T (p.Gln108Ter) single nucleotide variant Pathogenic/Likely pathogenic rs1060499630 GRCh37 Chromosome 1, 241676959: 241676959
2 FH NM_000143.3(FH): c.322C> T (p.Gln108Ter) single nucleotide variant Pathogenic/Likely pathogenic rs1060499630 GRCh38 Chromosome 1, 241513659: 241513659

Expression for Leiomyoma Cutis

Search GEO for disease gene expression data for Leiomyoma Cutis.

Pathways for Leiomyoma Cutis

GO Terms for Leiomyoma Cutis

Sources for Leiomyoma Cutis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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