Leiomyoma, Uterine (UL)

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Disease Ontology 11 DOID:13223 OMIM® 57 150699 ICD9CM 34 218 MeSH 43 D007889 NCIt 49 C3434 SNOMED-CT 68 44598004

ICD10 31 D25 MedGen 40 C0042133 SNOMED-CT via HPO 69 146801000119103 95315005 EFO 16 EFO_0000731 UMLS 71 C0042133 C2242776

MedlinePlus: ⁴¹ Uterine fibroids are the most common benign tumors in women of childbearing age. Fibroids are made of muscle cells and other tissues that grow in and around the wall of the uterus, or womb. The cause of fibroids is unknown. Risk factors include being African American or being overweight. Many women with fibroids have no symptoms. If you do have symptoms, they may include: Heavy or painful periods or bleeding between periods Feeling "full" in the lower abdomen Urinating often Pain during sex Lower back pain Reproductive problems, such as infertility, multiple miscarriages or early labor Your health care provider may find fibroids during a gynecological exam or by using imaging tests. Treatment includes drugs that can slow or stop their growth, or surgery. If you have no symptoms, you may not even need treatment. Many women with fibroids can get pregnant naturally. For those who cannot, infertility treatments may help. NIH: National Institute of Child Health and Human Development

MalaCards based summary: Leiomyoma, Uterine, also known as uterine leiomyoma, is related to kidney cancer and cystic echinococcosis, and has symptoms including pelvic pain An important gene associated with Leiomyoma, Uterine is MIRLET7C (MicroRNA Let-7c), and among its related pathways/superpathways are Interactions between immune cells and microRNAs in tumor microenvironment and miRNAs involved in DNA damage response. The drugs Progesterone and Cetrorelix have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related phenotype is uterine leiomyoma.

PubMed Health : ⁶³ Uterine fibroids: Many women have benign (non-cancerous) growths known as fibroids in or on their womb (uterus). Most fibroids are small and don't cause any problems. They are usually discovered by chance. Depending on where fibroids are located, they may cause period pain, heavy menstrual bleeding or other symptoms. There are different ways to treat fibroids. The most suitable treatment will greatly depend on a woman’s individual circumstances – such as whether she would still like to have children. Fibroids are made up of muscle cells and connective tissue. Their size, shape and location vary. Fibroids are mainly categorized based on where they are:

OMIM®: ⁵⁷ Uterine leiomyoma (UL), commonly known as fibroids, are benign tumors of the uterine myometrium. They represent the most prevalent pelvic tumors in women and are found in more than 75% of women of reproductive age. Approximately 20 to 25% of women with UL exhibit symptoms including menorrhagia, infertility, pelvic pain, and a range of complications during pregnancy. UL are the leading cause for hysterectomy in the United States, accounting for 30% of all hysterectomies (summary by Eggert et al., 2012). (150699) (Updated 08-Dec-2022)

Disease Ontology: ¹¹ An uterine benign neoplasm derived from the smooth muscle layer of the uterus.

Wikipedia: ⁷⁵ Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the... more...

Clinical features from OMIM®:

150699 (Updated 08-Dec-2022)

Fibroids usually only need to be treated if they are causing fertility problems or could cause problems during pregnancy . The choice of treatment will mainly depend on whether a woman would still like to have children – and how she sees the advantages and disadvantages of the various treatments . The severity of the symptoms and the size and position of the fibroids may also determine which treatments are an option. There is no rush to make a treatment decision. Fibroids usually grow very slowly. So you can take your time to read up on all of the pros and cons of the different treatments . Sometimes it is also a good idea to get several opinions from different doctors. The treatment goals may include the following: Reduce menstrual bleeding Relieve pain, cramps and tension Help with difficulties emptying the bladder and digestion Preserve or improve fertility The treatment options include: Hormone therapies : The main hormone therapies are hormonal contraceptives to reduce heavy menstrual bleeding , and hormones that prevent the production of estrogens (GnRH analogues). Surgical removal of the fibroid or the entire womb . Closing off the blood vessels that supply the fibroid with blood (uterine fibroid embolization). The aim is to shrink the fibroids . Other procedures like focused ultrasound surgery (FUS) . This is a relatively new procedure, and its advantages and disadvantages have not yet been fully studied. FUS uses high-intensity ultrasound waves to heat and destroy the fibroid . Other treatments like painkillers, herbal remedies or acupuncture . NSAID (non-steroidal anti-inflammatory drug) painkillers like ibuprofen or diclofenac have been proven to relieve period pain . But there are no studies that have specifically looked into the effects of NSAIDs in women with fibroids . This is also true for acupuncture . Some herbal remedies have been studied more than others, but there's currently no evidence that they are effective in treating fibroids.

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