Leiomyoma, Uterine (UL)

Categories: Cancer diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Leiomyoma, Uterine

MalaCards integrated aliases for Leiomyoma, Uterine:

Name: Leiomyoma, Uterine 56 39
Uterine Leiomyoma 12 36 29 54 6
Uterine Fibroids 42 15 62 71
Uterine Fibroid 12 15 17
Plexiform Leiomyoma 12 71
Leiomyoma of Corpus Uteri 12
Uterus Fibroma 12
Ul 56



somatic mutation

uterine leiomyomata are found in hereditary leiomyomatosis and renal cell cancer syndrome


leiomyoma, uterine:
Inheritance autosomal dominant inheritance somatic mutation


External Ids:

Disease Ontology 12 DOID:13223
OMIM 56 150699
KEGG 36 H01640
ICD9CM 34 218
MeSH 43 D007889
NCIt 49 C3434
SNOMED-CT 67 95315005
ICD10 32 D25
MedGen 41 C0042133
UMLS 71 C0042133 C2242776

Summaries for Leiomyoma, Uterine

MedlinePlus : 42 Uterine fibroids are the most common benign tumors in women of childbearing age. Fibroids are made of muscle cells and other tissues that grow in and around the wall of the uterus, or womb. The cause of fibroids is unknown. Risk factors include being African American or being overweight. Many women with fibroids have no symptoms. If you do have symptoms, they may include Heavy or painful periods or bleeding between periods Feeling "full" in the lower abdomen Urinating often Pain during sex Lower back pain Reproductive problems, such as infertility, multiple miscarriages or early labor Your health care provider may find fibroids during a gynecological exam or by using imaging tests. Treatment includes drugs that can slow or stop their growth, or surgery. If you have no symptoms, you may not even need treatment. Many women with fibroids can get pregnant naturally. For those who cannot, infertility treatments may help. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Leiomyoma, Uterine, also known as uterine leiomyoma, is related to breast disease and body mass index quantitative trait locus 11, and has symptoms including pelvic pain An important gene associated with Leiomyoma, Uterine is FH (Fumarate Hydratase), and among its related pathways/superpathways are MicroRNAs in cancer and Alzheimers Disease. The drugs Anastrozole and Dienogest have been mentioned in the context of this disorder. Affiliated tissues include uterus, smooth muscle and breast, and related phenotype is uterine leiomyoma.

Disease Ontology : 12 An uterine benign neoplasm derived from the smooth muscle layer of the uterus.

OMIM : 56 Uterine leiomyoma (UL), commonly known as fibroids, are benign tumors of the uterine myometrium. They represent the most prevalent pelvic tumors in women and are found in more than 75% of women of reproductive age. Approximately 20 to 25% of women with UL exhibit symptoms including menorrhagia, infertility, pelvic pain, and a range of complications during pregnancy. UL are the leading cause for hysterectomy in the United States, accounting for 30% of all hysterectomies (summary by Eggert et al., 2012). (150699)

KEGG : 36 Uterine leiomyoma, also known as fibroid, is the most common benign neoplasm of the female genital tract. It is a discrete, round, firm, often multiple uterine tumor composed of smooth muscle and connective tissue. The findings derived from high-throughput sequencing combined with previous knowledge have led to an emerging molecular classification of leiomyomas, suggesting that there are several distinct pathogenic pathways involved in leiomyoma formation. The evidence points to at least 4 molecular subclasses: leiomyomas with MED12 mutation, FH inactivation, HMGA2 overexpression, and COL4A6-COL4A5 deletion. While it is thought that the initial events that trigger leiomyoma tumorigenesis involves somatic mutations, it is evident that the development and growth of leiomyoma are highly dependent on ovarian steroid hormones, in particular, progesterone.

PubMed Health : 62 About uterine fibroids: Many women have benign (non-cancerous) growths known as fibroids in or on their womb (uterus). Most fibroids are small and don't cause any problems. They are usually discovered by chance. Depending on where fibroids are located, they may cause period pain, heavy menstrual bleeding or other symptoms. There are different ways to treat fibroids. The most suitable treatment will greatly depend on a woman’s individual circumstances – such as whether she would still like to have children. Fibroids are made up of muscle cells and connective tissue. Their size, shape and location vary. Fibroids are mainly categorized based on where they are:

Wikipedia : 74 Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the... more...

Related Diseases for Leiomyoma, Uterine

Diseases related to Leiomyoma, Uterine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 484)
# Related Disease Score Top Affiliating Genes
1 breast disease 30.7 MIR34A MIR335 MIR30A MIR27A MIR21 MIR139
2 body mass index quantitative trait locus 11 30.5 MIR34A MIR30A MIR27A MIR23B MIR21 MIR144
3 diffuse large b-cell lymphoma 30.5 MIR21 MIR150 MIR139 MIR10A
4 kidney cancer 30.5 MIR29C MIR27A MIR21 MIR150 FH
5 cervical cancer 30.4 MIRLET7C MIR34A MIR30A MIR23B MIR21 MIR196B
6 uterine anomalies 30.4 MIR542 MIR34A MIR335 MIR30A MIR29C MIR27A
7 esophageal cancer 30.3 MIR34A MIR30A MIR27A MIR21 MIR203A MIR144
8 lymphoma, non-hodgkin, familial 30.3 MIR34A MIR30A MIR27A MIR23B MIR21 MIR144
9 bladder cancer 30.3 MIR34A MIR29C MIR23B MIR21 MIR203A MIR144
10 ovarian cancer 30.2 MIRLET7C MIR542 MIR376B MIR34A MIR335 MIR30A
11 gastric cancer 30.0 MIR34A MIR30A MIR29C MIR27A MIR21 MIR203A
12 gastrointestinal system cancer 29.9 MIR542 MIR34A MIR335 MIR30A MIR29C MIR27A
13 prostate cancer 29.8 MIRLET7C MIR34A MIR335 MIR32 MIR30A MIR27A
14 renal cell carcinoma, nonpapillary 29.7 MIR34A MIR335 MIR30A MIR29C MIR27A MIR23B
15 pancreatic cancer 29.7 MIR34A MIR32 MIR30A MIR27A MIR23B MIR212
16 colorectal cancer 29.3 MIR542 MIR34A MIR335 MIR32 MIR30A MIR29C
17 submucous uterine fibroid 12.8
18 subserous uterine fibroid 12.8
19 blood group--ul system 12.3
20 renal cell carcinoma, papillary, 1 11.7
21 uterine corpus bizarre leiomyoma 11.5
22 uterus interstitial leiomyoma 11.4
23 uterine corpus lipoleiomyoma 11.4
24 uterine corpus myxoid leiomyosarcoma 11.4
25 uterine corpus epithelioid leiomyoma 11.3
26 uterine corpus dissecting leiomyoma 11.3
27 uterine corpus myxoid leiomyoma 11.3
28 uterine corpus apoplectic leiomyoma 11.3
29 uterine corpus cellular leiomyoma 11.3
30 leiomyoma 10.8
31 amenorrhea 10.8
32 infertility 10.7
33 herpes simplex 10.6
34 endometriosis 10.6
35 endocrine organ benign neoplasm 10.5 MIR335 MIR21 MIR139 FH
36 ovarian serous carcinoma 10.5 MIR27A MIR23B MIR21
37 pleural cancer 10.5 MIR32 MIR29C MIR139
38 placenta disease 10.5
39 miyoshi muscular dystrophy 1 10.5 MIR34A MIR335 MIR30A MIR21
40 inclusion body myositis 10.5 MIR34A MIR21 MIR197
41 intestinal benign neoplasm 10.5 MIR21 MIR139 MIR10A
42 gastrointestinal system benign neoplasm 10.5 MIR30A MIR21 MIR139 MIR10A
43 polymyositis 10.5 MIR30A MIR21
44 glioma susceptibility 1 10.5 MIR34A MIR23B MIR21 MIR197
45 dermatomyositis 10.5 MIR34A MIR335 MIR30A MIR21
46 vaginal discharge 10.5
47 tongue disease 10.5 MIR30A MIR21 MIR144 MIR139
48 laryngeal disease 10.5 MIR34A MIR21 MIR139
49 constipation 10.5
50 nemaline myopathy 10.5 MIR34A MIR335 MIR30A MIR29C

Graphical network of the top 20 diseases related to Leiomyoma, Uterine:

Diseases related to Leiomyoma, Uterine

Symptoms & Phenotypes for Leiomyoma, Uterine

Human phenotypes related to Leiomyoma, Uterine:

# Description HPO Frequency HPO Source Accession
1 uterine leiomyoma 31 HP:0000131

Symptoms via clinical synopsis from OMIM:

Genitourinary Internal Genitalia Female:
uterine leiomyomas, benign

Clinical features from OMIM:


UMLS symptoms related to Leiomyoma, Uterine:

pelvic pain

Drugs & Therapeutics for Leiomyoma, Uterine

PubMed Health treatment related to Leiomyoma, Uterine: 62

Fibroids usually only need to be treated if they are causing fertility problems or could cause problems during pregnancy . The choice of treatment will mainly depend on whether a woman would still like to have children – and how she sees the advantages and disadvantages of the various treatments . The severity of the symptoms and the size and position of the fibroids may also determine which treatments are an option. There is no rush to make a treatment decision. Fibroids usually grow very slowly. So you can take your time to read up on all of the pros and cons of the different treatments . Sometimes it is also a good idea to get several opinions from different doctors. The treatment goals may include the following: Reduce menstrual bleeding Relieve pain, cramps and tension Help with difficulties emptying the bladder and digestion Preserve or improve fertility The treatment options include: Hormone therapies : The main hormone therapies are hormonal contraceptives to reduce heavy menstrual bleeding , and hormones that prevent the production of estrogens (GnRH analogues). Surgical removal of the fibroid or the entire womb . Closing off the blood vessels that supply the fibroid with blood (uterine fibroid embolization). The aim is to shrink the fibroids . Other procedures like focused ultrasound surgery (FUS) . This is a relatively new procedure, and its advantages and disadvantages have not yet been fully studied. FUS uses high-intensity ultrasound waves to heat and destroy the fibroid . Other treatments like painkillers, herbal remedies or acupuncture . NSAID (non-steroidal anti-inflammatory drug) painkillers like ibuprofen or diclofenac have been proven to relieve period pain . But there are no studies that have specifically looked into the effects of NSAIDs in women with fibroids . This is also true for acupuncture . Some herbal remedies have been studied more than others, but there's currently no evidence that they are effective in treating fibroids.

Drugs for Leiomyoma, Uterine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 198)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
Dienogest Approved Phase 4 65928-58-7
Desogestrel Approved Phase 4 54024-22-5 40973
Cetrorelix Approved, Investigational Phase 4 120287-85-6 16129715 25074887
Goserelin Approved Phase 4 65807-02-5 5311128 47725
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
Acetaminophen Approved Phase 4 103-90-2 1983
Ibuprofen Approved Phase 4 15687-27-1 3672
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Ferrous fumarate Approved Phase 4 141-01-5
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
leucovorin Approved Phase 4 58-05-9 6006 143
Zinc Approved, Investigational Phase 4 7440-66-6 32051
Nicotinamide Approved, Investigational Phase 4 98-92-0 936
Hydroxocobalamin Approved Phase 4 13422-51-0 15589840 11953898
Zinc oxide Approved Phase 4 1314-13-2
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
Calcium carbonate Approved, Investigational Phase 4 471-34-1
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
Dinoprostone Approved Phase 4 363-24-6 5280360
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
Mifepristone Approved, Investigational Phase 4 84371-65-3 55245
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
Tranexamic Acid Approved Phase 4 1197-18-8 5526
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
Niacin Approved, Investigational, Nutraceutical Phase 4 59-67-6 938
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 59-43-8, 70-16-6 1130
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
Cobalamin Experimental Phase 4 13408-78-1 6857388
Fibrinolysin Investigational Phase 4 9004-09-5
44 Contraceptive Agents, Male Phase 4
45 Calciferol Phase 4
46 Antipyretics Phase 4
47 Sodium Channel Blockers Phase 4
48 Anti-Arrhythmia Agents Phase 4
49 Diuretics, Potassium Sparing Phase 4
50 Vitamin B 6 Phase 4

Interventional clinical trials:

(show top 50) (show all 297)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of High Intensity Focused Ultrasound Ablation Compared With Myomectomy in Uterine Fibroids:A Randomized Controlled Study Unknown status NCT01239641 Phase 4
2 A Controlled Trial on Uterine Fibroids Treatment Comparing Aromatase Inhibitor Plus GnRH Analogue Versus Ulipristal Acetate Unknown status NCT03421639 Phase 4 Ulipristal acetate;Aromatase inhibitor plus GnRH analog
3 Endometrial Preparation Before Operative Hysteroscopy in Premenopausal Women Unknown status NCT02440750 Phase 4 Dienogest;Ulipristal acetate
4 Abnormal Uterine Bleeding in Women With Uterine Leiomyomas: Open Randomized Clinical Trial Of Non Inferiority Between Oral Dienogest, Oral Desogestrel and Subcutaneous Goserelin Unknown status NCT01738724 Phase 4 Dienogest;Goserelin;Desogestrel
5 Ulipristal Acetate Versus GnRH Analogue Treatment Before Hysteroscopic Resection of Uterine Leiomyoma Unknown status NCT02361879 Phase 4 ulipristal acetate;Leuprolide acetate
6 The Effect of UPA on Women Ovarian Reserve Unknown status NCT02361892 Phase 4 ulipristal acetate
7 Ulipristal Acetate Versus GnRH Analogue for Myometrial Preservation in Patients With Submucosal Uterine Leiomyoma G2 Unknown status NCT02357563 Phase 4 ulipristal acetate;Leuprolide acetate
8 Advantages of Ulipristal Acetate for the Preoperative Treatment of Hypoechoic Cellular Leiomyomas Unknown status NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate
9 A Prospective, Randomized, Single-Center Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
10 Novel Magnetic Resonance Imaging Strategies as a Non-invasive Biomarker of Vascular and Extracellular Matrix Morphology in Women With Uterine Fibroids. Completed NCT00746031 Phase 4 GnRH analogue (Zoladex);GnRH antagonist-Cetrorelix
11 A Prospective, Double Blind, Randomized, Placebo Controlled Study to Compare the Effectiveness of Intravenous Acetaminophen and Intravenous Ibuprofen in Reducing Post Procedural Pain in the Uterine Fibroid Embolization Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;Intravenous placebo/Intravenous placebo
12 Phase 4 Study of Magnetic Resonance Guided Focused Ultrasound Surgery Following Gonadotrophin Releasing Hormone Agonist Treatment for Symptomatic Uterine Fibroids Completed NCT00159328 Phase 4
13 Pilot of Letrozole for Uterine Myomas Completed NCT02470741 Phase 4 Letrozole
14 Uterine Fibroids Are a Very Common Finding in Women of Reproductive Age. Ready Safety Study Dydrogesterone + Multivitamin Nature in Women of Reproductive Age and Women Pregnancy Completed NCT02620345 Phase 4 Dydrogesterone M ( case 1 );Dydrogesterone M ( case 2 )
15 The FIRSTT Study: Comparing Focused Ultrasound and Uterine Artery Embolization for Uterine Fibroids Completed NCT00995878 Phase 4
16 Understanding Experimentally Induced Hot Flushes and Their Impact on Sleep and Mood Completed NCT00455689 Phase 4 Leuprolide acetate
17 Intra-arterial Lidocaine for Pain Control Post Uterine Fibroid Embolization : a Single-center Prospective Randomized Study Completed NCT02293447 Phase 4 Lidocaine per-embolization;Lidocaine post-embolization
18 Impact of Experimentally Induced Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
19 Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy: A Randomized Controlled Study Completed NCT02154932 Phase 4 2 doses 400 microgram misoprostol;single dose misoprostol
20 Effect of Oxytocin Infusion on Blood Loss During Abdominal Myomectomy Completed NCT03308643 Phase 4 Oxytocin
21 Efficacy and Safety of Prevadh™ in the Prevention of Adhesions in Gynaecological Surgery: a Multicenter, Randomized, French Study Completed NCT01388907 Phase 4
22 Barbed Suture vs Smooth Suture for Vaginal Cuff Closure, a Randomized Trial Completed NCT01262573 Phase 4
23 Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis Recruiting NCT03500367 Phase 4 rapamycin
24 Prospective Randomized Trial of Tranexamic Acid Versus Levonorgestrel Intrauterine System for the Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids Recruiting NCT03317795 Phase 4 Levonorgestrel IUS;Tranexamic Acid
25 A Randomized Control Trial of Combined Vaginal Misoprostol and Perivascular Vasopressin During Robotic Myomectomy Recruiting NCT03815344 Phase 4 Standard;Standard-vaginal misoprostol
26 Bioenergetic and Metabolic Consequences of the Loss of Ovarian Function in Women - 2018 Recruiting NCT04043520 Phase 4 GnRH antagonist;Estrogen Product;Placebo estradiol;Placebo GnRH antagonist
27 The Effectiveness and Safety of Ulipristal Acetate in Women With Symptomatic Uterine Fibroid Terminated NCT04132349 Phase 4 Ulipristal Acetate 5 mg
28 Mifepristone Tablets in the Treatment of Symptomatic Uterine Fibroids With Safety and Efficacy in Open, Multicenter Phase IV Clinical Studies Terminated NCT03210324 Phase 4 Mifepristone tablets
29 Magnetic Resonance Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids in Women Desiring Future Pregnancies Terminated NCT00180739 Phase 4
30 A Prospective Randomized Blinded Placebo Controlled Comparison of Multimodal Pre-emptive Analgesia on Long Term Outcome Following Uterine Artery Embolization Terminated NCT01555073 Phase 4 pregabalin/celecoxib;pregabalin/placebo;celecoxib/placebo;Placebo group
31 Pilot Study on the Pre-operative Use of Ulipristal on Fibroid in Chinese Population Terminated NCT02825719 Phase 4 Ulipristal acetate;Ferrous sulphate;Tranexamic Acid
32 Multi-Center Clinical Trial of Uterine Artery Embolization Treatment of Uterine Leiomyoma Unknown status NCT00821275 Phase 2, Phase 3
33 Influence of the Aromatase Inhibitor Anastrozole and GnRH Analog Goserelin Acetate as Preoperative Treatment of Vaginal Surgical Treatment of Uterine Leiomyoma: Analysis of Intra and Immediate/Late Postoperative Patterns Unknown status NCT01280045 Phase 3
34 Efficacy and Safety of Pre-operative Vaginal Misoprostol in Reduction of Intraoperative Blood Loss During Myomectomy. Amulticentre Single Blind Randomized Trial. Unknown status NCT03509168 Phase 2, Phase 3 Misoprostol Pfizer Brand
35 Evaluation the Effect of Simvastatin on Uterine Leiomyoma Development and Growth in Infertile Patients Unknown status NCT03134157 Phase 3 oral drug and vaginal placebo;oral drug and oral placebo;Vaginal placebo+ oral placebo
36 A Double-blind, Randomized, Two-dose Trial of Tumor-shrinking Decoction (TSD), a Chinese Medicine Preparation in Patients With Symptomatic Uterine Fibroids Unknown status NCT02189083 Phase 3 TSD
37 MR Guided Focused Ultrasound Surgery in the Treatment of Uterine Fibroids: Clinical Study to Validate the Changes to ExAblate 2000 Device Completed NCT00295217 Phase 3
38 A Clinical Study To Evaluate the Safety and Efficacy of MR Guided Focused Ultrasound Treatment of Uterine Fibroids With Enhanced Sonication Techniques Completed NCT00365989 Phase 3
39 Therapeutic MRI Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids Completed NCT01141062 Phase 3
40 Clinical Trial Protocol for Therapeutic MRI-guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids in a 3T MRI Scanner Completed NCT01064960 Phase 3
41 Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Completed NCT02925494 Phase 3 Estradiol/Norethindrone Acetate;Elagolix
42 Mifepristone 5 mg Versus 10 mg for the Treatment of Uterine Leiomyomata. A Randomized, Double Blinded Clinical Trial. Completed NCT00712595 Phase 2, Phase 3 Mifepristone;Mifepristone
43 A Phase 3 Study to Evaluate the Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Completed NCT02654054 Phase 3 Elagolix;Placebo for Estradiol/Norethindrone Acetate;Estradiol/Norethindrone Acetate;Placebo for Elagolix
44 A Phase 3 Study to Evaluate the Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Completed NCT02691494 Phase 3 Elagolix;Placebo for Estradiol/Norethindrone Acetate;Estradiol/Norethindrone Acetate;Placebo for Elagolix
45 Placebo-controlled,Doubled,Randomized Trial Evaluating the Effect of Intravenous Ascorbic Acid on Intraoperative Blood Loss in Women Undergoing Laparoscopic Myomectomy Completed NCT01715597 Phase 3 ascorbic acid;Normal saline
46 Uterine Fibroids: Impact of Ulipristal Acetate 10 mg on ART Results Completed NCT02425878 Phase 3 Ulipristal Acetate;Placebo
47 A Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Oral TAK-385 40 mg in the Treatment of Pain Symptoms Associated With Uterine Fibroids Completed NCT02655224 Phase 3 Relugolix;Relugolix placebo
48 A Phase III, 12-Month, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Two Doses of J867 Versus Placebo in Subjects With Uterine Leiomyomata. Completed NCT00160381 Phase 3 Asoprisnil;Asoprisnil;Placebo
49 A Phase 3, 12-Month, Extension Study to Evaluate the Safety of Asoprisnil in Subjects With Uterine Leiomyomata Completed NCT00156195 Phase 3 Asoprisnil;Asoprisnil
50 A Phase III, 12-Month, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety (Including Bone Density Assessment) of Two Doses of J867 Versus Placebo in Subjects With Uterine Leiomyomata Completed NCT00152269 Phase 3 Asoprisnil;Asoprisnil;Placebo

Search NIH Clinical Center for Leiomyoma, Uterine

Genetic Tests for Leiomyoma, Uterine

Genetic tests related to Leiomyoma, Uterine:

# Genetic test Affiliating Genes
1 Uterine Leiomyoma 29

Anatomical Context for Leiomyoma, Uterine

MalaCards organs/tissues related to Leiomyoma, Uterine:

Uterus, Smooth Muscle, Breast, Testes, Lung, Prostate, Bone

Publications for Leiomyoma, Uterine

Articles related to Leiomyoma, Uterine:

(show top 50) (show all 2232)
# Title Authors PMID Year
Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studies. 56 54
15334541 2004
Allelotype of uterine leiomyomas. 61 56
10549262 1999
Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. 56 54
9892177 1999
Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium. 54 56
9253340 1997
Involvement of the long arm of chromosome 12 in chromosome rearrangements of uterine leiomyoma. 61 56
3355999 1988
Genome-wide linkage and association analyses implicate FASN in predisposition to Uterine Leiomyomata. 56
23040493 2012
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. 56
21868628 2011
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids. 56
21460842 2011
Uterine leiomyomata and decreased height: a common HMGA2 predisposition allele. 56
19132395 2009
Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium. 61 46
17765232 2008
Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma. 61 46
18403645 2008
A specific translocation, t(12;14)(q14-15;q23-24), characterizes a subgroup of uterine leiomyomas. 56
3355995 1988
Efficacy assessment of acupuncture in improving symptoms of uterine fibroids: A randomized controlled trial. 42
32358379 2020
Radial neuropathy caused by intraneural leiomyoma: A case report. 42
32481384 2020
Identification of gastrointestinal stromal tumors from leiomyomas in the esophagogastric junction: A single-center review of 136 cases. 42
32332661 2020
Cell-type specific actions of progesterone receptor modulators in the regulation of uterine leiomyoma growth. 54 61
20414849 2010
The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells. 61 54
20056218 2010
Dietary glycemic index and load in relation to risk of uterine leiomyomata in the Black Women's Health Study. 61 54
20200259 2010
Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells. 61 54
20124487 2010
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. 61 54
19135657 2010
No association between estrogen receptor beta polymorphisms and uterine leiomyoma. 61 54
19715484 2009
A panel of antibodies to determine site of origin and malignancy in smooth muscle tumors. 54 61
19734847 2009
Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas. 54 61
19700613 2009
Ascites in puerperium: a rare case of atypical pseudo-Meigs' syndrome complicating the puerperium. 54 61
19322576 2009
Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells. 54 61
19808856 2009
Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells. 61 54
19809499 2009
Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A:B. 61 54
19499404 2009
Uterine leiomyomata in relation to insulin-like growth factor-I, insulin, and diabetes. 54 61
19305350 2009
Pulmonary benign metastasizing leiomyoma in a postmenopausal woman. 61 54
19506459 2009
High aromatase expression in uterine leiomyoma tissues of African-American women. 54 61
19240151 2009
Sex hormone binding globulin and aging. 54 61
18956301 2009
Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas. 61 54
19151755 2009
Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients. 61 54
18249392 2009
Sex steroidal modulation of collagen metabolism in uterine leiomyomas. 61 54
19400409 2009
Development of an early biomarker for the ovarian liability of selective estrogen receptor modulators in rats. 61 54
18824103 2008
The expression of estrogen receptor isoforms alpha, beta and insulin-like growth factor-I in uterine leiomyoma. 61 54
19012097 2008
Combined differential gene expression profile and pathway enrichment analyses to elucidate the molecular mechanisms of uterine leiomyoma after gonadotropin-releasing hormone treatment. 61 54
18258233 2008
Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation. 54 61
18701604 2008
Labial aggressive angiomyxoma associated with endometrial hyperplasia and uterine leiomyoma: a case report and review of the literature. 54 61
18839858 2008
Association of the CYP17 gene polymorphism with risk for uterine leiomyoma in Brazilian women. 54 61
18645709 2008
Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas. 61 54
18231572 2008
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer. 61 54
18281245 2008
Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells. 54 61
18216291 2008
CCAAT/enhancer binding protein beta regulates aromatase expression via multiple and novel cis-regulatory sequences in uterine leiomyoma. 61 54
18182446 2008
Inhibition of proliferation and transforming growth factor beta3 protein expression by peroxisome proliferators-activated receptor gamma ligands in human uterine leiomyoma cells. 61 54
18272045 2008
Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population. 61 54
18390078 2008
Action of progesterone receptor modulators on uterine leiomyomas. 61 54
18754282 2008
Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas. 54 61
18601603 2008
Early growth response gene-1 plays a pivotal role in down-regulation of a cohort of genes in uterine leiomyoma. 54 61
17975260 2007
Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. 54 61
17785366 2007

Variations for Leiomyoma, Uterine

ClinVar genetic disease variations for Leiomyoma, Uterine:

6 (show all 31) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MED12 NM_005120.3(MED12):c.131G>A (p.Gly44Asp)SNV other 92220 rs199469672 X:70339254-70339254 X:71119404-71119404
2 MED12 NM_005120.3(MED12):c.130G>A (p.Gly44Ser)SNV other 92217 rs199469669 X:70339253-70339253 X:71119403-71119403
3 FH NM_000143.3(FH):c.322C>T (p.Gln108Ter)SNV Pathogenic/Likely pathogenic 393560 rs1060499630 1:241676959-241676959 1:241513659-241513659
4 PTCH1 NM_001083602.2(PTCH1):c.-241deldeletion Uncertain significance 523402 rs1554710890 9:98278994-98278994 9:95516712-95516712
5 HMGA2 NM_003483.4(HMGA2):c.283-2A>GSNV Uncertain significance 800987 12:66357023-66357023 12:65963243-65963243
6 MED12 NM_005120.3(MED12):c.100-1_139deldeletion not provided 92197 rs199469676 X:70339221-70339261 X:71119371-71119411
7 MED12 NM_005120.3(MED12):c.100_141del (p.Asp34_Asn47del)deletion not provided 92198 rs199469677 X:70339223-70339264 X:71119373-71119414
8 MED12 NM_005120.3(MED12):c.100-8T>ASNV not provided 92199 rs199469675 X:70339215-70339215 X:71119365-71119365
9 MED12 NM_005120.3(MED12):c.103_138del (p.Glu35_Asn46del)deletion not provided 92200 rs199469678 X:70339224-70339259 X:71119374-71119409
10 MED12 NM_005120.3(MED12):c.107T>G (p.Leu36Arg)SNV not provided 92201 rs199469667 X:70339230-70339230 X:71119380-71119380
11 MED12 NM_005120.3(MED12):c.107_111delinsGC (p.Leu36_Thr37delinsArg)indel not provided 92202 rs199469679 X:70339230-70339234 X:71119380-71119384
12 MED12 NM_005120.3(MED12):c.111_155del (p.Ala38_Ser52del)deletion not provided 92203 rs199469681 X:70339233-70339277 X:71119383-71119427
13 MED12 NM_005120.3(MED12):c.113_121del (p.Ala38_Asn40del)deletion not provided 92204 rs199469682 X:70339235-70339243 X:71119385-71119393
14 MED12 NM_005120.3(MED12):c.117_122del (p.Asn40_Val41del)deletion not provided 92205 rs199469683 X:70339239-70339244 X:71119389-71119394
15 MED12 NM_005120.3(MED12):c.118_132del (p.Asn40_Gly44del)deletion not provided 92206 rs199469684 X:70339241-70339255 X:71119391-71119405
16 MED12 NM_005120.3(MED12):c.118_134delinsTA (p.Asn40_Phe45delinsTyr)indel not provided 92207 rs199469680 X:70339241-70339257 X:71119391-71119407
17 MED12 NM_005120.3(MED12):c.118_146delinsTT (p.Asn40_Pro49delinsPhe)indel not provided 92208 rs199469685 X:70339241-70339269 X:71119391-71119419
18 MED12 NM_005120.3(MED12):c.122_148del (p.Val41_Pro49del)deletion not provided 92209 rs199469686 X:70339243-70339269 X:71119393-71119419
19 MED12 NM_005120.3(MED12):c.122_163del (p.Val41_Asp54del)deletion not provided 92210 rs199469687 X:70339242-70339283 X:71119392-71119433
20 MED12 NM_005120.3(MED12):c.123_152del (p.Lys42_Val51del)deletion not provided 92211 rs199469688 X:70339243-70339272 X:71119393-71119422
21 MED12 NM_005120.3(MED12):c.126_131del (p.Lys42_Gly44delinsAsn)deletion not provided 92212 rs199469689 X:70339249-70339254 X:71119399-71119404
22 MED12 NM_005120.3(MED12):c.126_140del (p.Lys42_Asn46del)deletion not provided 92213 rs199469690 X:70339247-70339261 X:71119397-71119411
23 MED12 NM_005120.3(MED12):c.128A>C (p.Gln43Pro)SNV not provided 92214 rs199469668 X:70339251-70339251 X:71119401-71119401
24 MED12 NM_005120.3(MED12):c.129_137del (p.Gln43_Asn46delinsHis)deletion not provided 92215 rs199469691 X:70339251-70339259 X:71119401-71119409
25 MED12 NM_005120.3(MED12):c.129_143del (p.Gly44_Gln48del)deletion not provided 92216 rs199469692 X:70339250-70339264 X:71119400-71119414
26 MED12 NM_005120.3(MED12):c.130G>C (p.Gly44Arg)SNV not provided 92218 rs199469669 X:70339253-70339253 X:71119403-71119403
27 MED12 NM_005120.3(MED12):c.130G>T (p.Gly44Cys)SNV not provided 92219 rs199469669 X:70339253-70339253 X:71119403-71119403
28 MED12 NM_005120.3(MED12):c.131G>C (p.Gly44Ala)SNV not provided 92221 rs199469672 X:70339254-70339254 X:71119404-71119404
29 MED12 NM_005120.3(MED12):c.131G>T (p.Gly44Val)SNV not provided 92222 rs199469672 X:70339254-70339254 X:71119404-71119404
30 MED12 NM_005120.3(MED12):c.133_144del (p.Phe45_Gln48del)deletion not provided 92223 rs199469693 X:70339256-70339267 X:71119406-71119417
31 MED12 NM_005120.3(MED12):c.149_163del (p.Ala50_Asp54del)deletion not provided 92224 rs199469694 X:70339270-70339284 X:71119420-71119434

Copy number variations for Leiomyoma, Uterine from CNVD:

# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 70739 12 64503703 64646338 Duplication HMGA2 Uterine leiomyoma
2 230938 8 100959547 100975071 Translate COX6C Uterine leiomyoma

Expression for Leiomyoma, Uterine

Search GEO for disease gene expression data for Leiomyoma, Uterine.

Pathways for Leiomyoma, Uterine

Pathways related to Leiomyoma, Uterine according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 MIRLET7C MIR34A MIR335 MIR32 MIR30A MIR29C
2 11.61 MIR21 MIR139 MIR10A
3 11.26 MIR30A MIR212 MIR10A
4 10.96 MIR542 MIR27A MIR23B MIR203A
5 10.77 MIRLET7C MIR29C

GO Terms for Leiomyoma, Uterine

Cellular components related to Leiomyoma, Uterine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 MIRLET7C MIR335 MIR30A MIR29C MIR27A MIR23B
2 extracellular vesicle GO:1903561 9.17 MIRLET7C MIR34A MIR30A MIR29C MIR27A MIR23B

Biological processes related to Leiomyoma, Uterine according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 MIR34A MIR30A MIR23B MIR212 MIR21 MIR144
2 negative regulation of gene expression GO:0010629 9.8 MIR29C MIR27A MIR23B MIR212 MIR21 MIR144
3 negative regulation of cell migration GO:0030336 9.75 MIR34A MIR29C MIR21
4 transforming growth factor beta receptor signaling pathway GO:0007179 9.67 MIR30A MIR212 MIR21
5 miRNA mediated inhibition of translation GO:0035278 9.67 MIR30A MIR27A MIR212 MIR21
6 negative regulation of angiogenesis GO:0016525 9.65 MIR34A MIR29C MIR212 MIR21 MIR10A
7 gene silencing by miRNA GO:0035195 9.6 MIRLET7C MIR542 MIR376B MIR34A MIR335 MIR32
8 negative regulation of vascular endothelial cell proliferation GO:1905563 9.58 MIR34A MIR29C
9 positive regulation of vascular endothelial cell proliferation GO:1905564 9.57 MIR27A MIR21
10 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.56 MIR34A MIR21
11 negative regulation of cholesterol efflux GO:0090370 9.55 MIR27A MIR144
12 positive regulation of cellular senescence GO:2000774 9.54 MIR34A MIR10A
13 negative regulation of interleukin-8 secretion GO:2000483 9.52 MIRLET7C MIR203A
14 positive regulation of endothelial cell differentiation GO:0045603 9.51 MIR21 MIR150
15 negative regulation of interleukin-8 biosynthetic process GO:0045415 9.48 MIRLET7C MIR203A
16 negative regulation of cell cycle G1/S phase transition GO:1902807 9.46 MIR29C MIR10A
17 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.46 MIR27A MIR23B MIR150 MIR10A
18 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.43 MIR27A MIR21
19 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.26 MIR27A MIR23B MIR21 MIR10A

Molecular functions related to Leiomyoma, Uterine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.44 MIRLET7C MIR34A MIR32 MIR30A MIR29C MIR27A

Sources for Leiomyoma, Uterine

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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