MCID: LMR001
MIFTS: 50

Lemierre's Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lemierre's Syndrome

MalaCards integrated aliases for Lemierre's Syndrome:

Name: Lemierre's Syndrome 12 76 15
Lemierre Syndrome 12 53 59 73
Fusobacterium Infections 44 73
Necrobacillosis 53 73
Oropharyngeal Infection Leading to Secondary Septic Thrombophlebitis of the Internal Jugular Vein 53
Postanginal Sepsis Secondary to Orophyngeal Infection 59
Septic Phlebitis of the Internal Jugular Vein 59
Lemierre Postanginal Sepsis 59
Human Necrobacillosis 12
Postanginal Sepsis 12
Acute Sore Throat 12

Characteristics:

Orphanet epidemiological data:

59
lemierre syndrome
Age of onset: Adolescent; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11337
ICD9CM 35 040.3
MeSH 44 D005674
SNOMED-CT 68 52542005
Orphanet 59 ORPHA137839
UMLS via Orphanet 74 C0343525
ICD10 via Orphanet 34 I80.8
MESH via Orphanet 45 D057831

Summaries for Lemierre's Syndrome

NIH Rare Diseases : 53 Lemierre syndrome is a rare and potentially life-threatening infection. The bacteria typically responsible is Fusobacterium necrophorum, although a variety of bacteria types may cause the condition. The bacterial infection begins in the throat and spreads through the lymphatic vessels. Symptoms include sore throat and fever, followed by swelling of the internal jugular vein (IJV). Subsequently, pus-containing tissue moves from the original location to various organs, most commonly the lungs. Other affected sites may include the joints, muscles, skin and soft tissue, liver, and/or spleen. Treatment involves the use of intravenous antibiotics.

MalaCards based summary : Lemierre's Syndrome, also known as lemierre syndrome, is related to thrombosis and thrombophlebitis. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Selenium Micronutrient Network and Adhesion. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lung and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia : 76 Lemierre''s syndrome refers to infectious thrombophlebitis of the internal jugular vein. It most often... more...

Related Diseases for Lemierre's Syndrome

Diseases related to Lemierre's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 thrombosis 30.6 F3 MTHFR SERPINE1
2 thrombophlebitis 30.5 MTHFR SERPINE1
3 mastoiditis 30.4 CRP MTHFR
4 mediastinitis 30.2 CRP DNM1
5 sphenoid sinusitis 30.0 CRP SLC25A16
6 thrombophilia due to thrombin defect 29.7 F3 MTHFR SERPINE1
7 thrombophilia 29.6 F11 F3 MTHFR SERPINE1
8 stroke, ischemic 29.4 CRP F3 MTHFR PLG SERPINE1
9 pharyngitis 11.9
10 pfeiffer syndrome 10.3
11 adult respiratory distress syndrome 10.3
12 acquired hemophilia 10.2 F11 F3
13 acquired hemophilia a 10.2 F11 F3
14 bone epithelioid hemangioma 10.2 F3 SMUG1
15 partial motor epilepsy 10.2 F3 SMUG1
16 ischemic neuropathy 10.2 CRP MTHFR
17 gastrointestinal tuberculosis 10.2 CRP SMUG1
18 aortitis 10.2 CRP SMUG1
19 pulmonary artery leiomyosarcoma 10.2 PLG SMUG1
20 testicular infarct 10.2 CRP MTHFR
21 alcohol-related birth defect 10.2 F11 F3
22 conjugate gaze palsy 10.2 F3 PLG
23 cerebral falx meningioma 10.2 F3 PLG
24 marantic endocarditis 10.2 F3 MTHFR
25 leech infestation 10.2 F3 PLG
26 acquired angioedema 10.2 C3 CRP
27 intestinal impaction 10.2 F3 PLG
28 acute maxillary sinusitis 10.2 C3 CRP
29 cartilage disease 10.2 CRP SMUG1
30 giant hemangioma 10.2 F3 PLG
31 suppurative otitis media 10.2 CRP TLR5
32 femoral neuropathy 10.2 F3 PLG
33 hepatic infarction 10.2 F3 MTHFR
34 central nervous system vasculitis 10.2 CRP SMUG1
35 carotid artery dissection 10.2 HOTAIR MTHFR PLG
36 multicentric castleman disease 10.2 CRP F3
37 basilar artery occlusion 10.2 PLG SLC25A16
38 von willebrand disease, type 3 10.2 F11 F3 TLR5
39 pulmonary aspergilloma 10.2 CRP SMUG1
40 anterior cranial fossa meningioma 10.2 F3 PLG
41 inferior vena cava interruption 10.1 MTHFR SERPINE1
42 korean hemorrhagic fever 10.1 F3 PLG
43 neonatal stroke 10.1 MTHFR SERPINE1
44 amaurosis fugax 10.1 MTHFR SERPINE1
45 intracranial thrombosis 10.1 F3 MTHFR PLG
46 phototoxic dermatitis 10.1 C3 KNG1
47 pulmonary artery disease 10.1 F3 MTHFR PLG
48 blood coagulation disease 10.1 F3 MTHFR PLG
49 vertebral artery occlusion 10.1 F3 PLG SLC25A16
50 afibrinogenemia 10.1 C3 F11 F3

Graphical network of the top 20 diseases related to Lemierre's Syndrome:



Diseases related to Lemierre's Syndrome

Symptoms & Phenotypes for Lemierre's Syndrome

MGI Mouse Phenotypes related to Lemierre's Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.93 ALK C3 CRP DNM1 F11 F3
2 cardiovascular system MP:0005385 9.91 C3 CRP DNM1 F11 F3 KDM4A
3 liver/biliary system MP:0005370 9.43 C3 F11 MTHFR PLG SERPINE1 TLR5
4 respiratory system MP:0005388 9.1 ALK F11 F3 PLG SERPINE1 TLR5

Drugs & Therapeutics for Lemierre's Syndrome

Drugs for Lemierre's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Microbiology of Para- og Retropharyngeal Abscess Recruiting NCT02640456

Search NIH Clinical Center for Lemierre's Syndrome

Cochrane evidence based reviews: fusobacterium infections

Genetic Tests for Lemierre's Syndrome

Anatomical Context for Lemierre's Syndrome

MalaCards organs/tissues related to Lemierre's Syndrome:

41
Tonsil, Lung, Liver, Skin, Spleen, Bone, Heart

Publications for Lemierre's Syndrome

Articles related to Lemierre's Syndrome:

(show top 50) (show all 463)
# Title Authors Year
1
A Case of Lemierre's Syndrome in Intensive Care Unit. ( 29531456 )
2018
2
Lemierre's syndrome: A persistent unusual neck pain and swelling. ( 29796209 )
2018
3
Lemierre's syndrome: a rare cause of sepsis presenting with an absence of throat symptoms. ( 29705735 )
2018
4
Lemierre's syndrome: cavitary lung disease caused by uncommon bacteria. ( 29669776 )
2018
5
Lemierre's syndrome: a pain in the neck with far-reaching consequences. ( 29298792 )
2018
6
Lesson of the month 1: Lemierre's syndrome: a reminder of the 'forgotten disease'. ( 29436449 )
2018
7
Lemierre's syndrome presented with acute pancreatitis. ( 29657730 )
2018
8
Lemierre's syndrome following perianal abscess: A case report. ( 29573596 )
2018
9
The co-existence of Lemierre's syndrome and Bezold's abscesses due to Streptococcus constellatus: A case report. ( 29952983 )
2018
10
Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )
2018
11
Lemierre's syndrome leading to cerebral venous thrombosis. ( 29898085 )
2018
12
Lemierre's syndrome: a case study with a short review of literature. ( 29783881 )
2018
13
Brugada syndrome in a 4-year-old child with Lemierre syndrome-A case report. ( 29910587 )
2018
14
Atypical Presentation of Lemierre's Syndrome Causing Septic Shock and Acute Respiratory Distress Syndrome. ( 30057835 )
2018
15
Bacterial Arthritis of the Hip Due to Lemierre Syndrome: A Case Report. ( 30431478 )
2018
16
Lemierre Syndrome in Adolescent with Active Ulcerative Colitis. ( 29992123 )
2018
17
Lemierre's syndrome and 2016 American College of Physician guidelines for pharyngitis: no to empiric coverage for bacterial pharyngitis. While no role for routine Fusobacterium PCR, keep suspicion for this pathogen. ( 30030249 )
2018
18
Cone beam computed tomography-guided transpterygoidal aspiration of a carotid space abscess in Lemierre's syndrome. ( 30042808 )
2018
19
Lemierre's Syndrome in an Aseptic Patient with Systemic Lupus Erythematosus. ( 30109797 )
2018
20
Lemierre's syndrome: A forgotten complication of acute pharyngitis. ( 30291034 )
2018
21
Fatal Fusobacterium necrophorum infection with gynecological Lemierre's syndrome. ( 30309662 )
2018
22
Purpura fulminans with Lemierre's syndrome caused by Gemella bergeri and Eikenella corrodens: a case report. ( 30340466 )
2018
23
Lemierre's syndrome: a life-threatening sore throat. ( 30368479 )
2018
24
Lemierre's Syndrome. ( 30410696 )
2018
25
Lemierre's syndrome: One rare disease-Two case studies. ( 30484880 )
2018
26
A case of Lemierre's syndrome with disturbed venous flow confirmed by conventional angiography. ( 30504581 )
2018
27
Intravascular abscess in Lemierre's syndrome due to meticillin-sensitive Staphylococcus aureus. ( 30507410 )
2018
28
Porphyromonas asaccharolytica as a Rare Causative Agent for Lemierre's Syndrome. ( 30533234 )
2018
29
Senile Lemierre syndrome complicated with descending necrotizing mediastinitis: A case report. ( 30170383 )
2018
30
Fissuration of vertebral artery mycotic aneurysm due to Lemierre syndrome. ( 28652095 )
2018
31
Neonatal Lemierre Syndrome: Youngest Reported Case and Literature Review. ( 28719983 )
2018
32
Septic thrombosis of cavernous sinus extended to the ipsilateral internal jugular vein and transversal sinus with favorable outcome: Clinical and radiological features of a Lemierre syndrome. ( 29040036 )
2018
33
Lemierre Syndrome as a Complication of Laryngeal Carcinoma. ( 29849275 )
2018
34
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. ( 30071559 )
2018
35
INTRAOCULAR JARISCH-HERXHEIMER REACTION IN LEMIERRE SYNDROME. ( 30074939 )
2018
36
Rare and life-threatening complication after an attempted lower third molar extraction: Lemierre syndrome. ( 30372118 )
2018
37
Pathological fracture of the femoral neck following septic coxitis and chronic osteomyelitis: a potential complication of Lemierre's syndrome. ( 28536211 )
2017
38
Lemierre's syndrome, necrotizing pneumonia and staphylococcal septic shock treated with extracorporeal life support. ( 28835825 )
2017
39
Bilateral Cavernous Sinus Thrombosis in Lemierre's Syndrome. ( 28148337 )
2017
40
Necrotizing Lip Infection Causing Septic Thrombophlebitis of the Neck: AA Rare Variant of Lemierre Syndrome. ( 28651067 )
2017
41
Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. ( 28877155 )
2017
42
Lemierre's syndrome; a rare cause of septic arthritis. ( 28500126 )
2017
43
Lemierre's syndrome: Case report and brief literature review. ( 28808620 )
2017
44
Lemierre's Syndrome with Cavernous Sinus Thrombosis. ( 28381765 )
2017
45
Mycotic Pseudoaneurysm of Internal Carotid Artery Secondary to Lemierre's Syndrome, How to Do It. ( 28549960 )
2017
46
Lemierre's Syndrome: More Than Just a Sore Throat. ( 28822361 )
2017
47
Utility of PET scan in diagnosis and monitoring descending necrotizing mediastinitis complicating Lemierre's syndrome. ( 28776174 )
2017
48
Lemierre's syndrome variant of the gut. ( 29054895 )
2017
49
Variant of Lemierre's syndrome with internal jugular vein aneurysm. ( 29275396 )
2017
50
Pulmonary embolism and internal jugular vein thrombosis as evocative clues of Lemierre's syndrome: A case report and review of the literature. ( 28352635 )
2017

Variations for Lemierre's Syndrome

Expression for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.

Pathways for Lemierre's Syndrome

GO Terms for Lemierre's Syndrome

Cellular components related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 C3 CRP F11 F3 KNG1 PLG
2 blood microparticle GO:0072562 9.43 C3 KNG1 PLG
3 collagen-containing extracellular matrix GO:0062023 9.26 F3 KNG1 PLG SERPINE1
4 platelet alpha granule lumen GO:0031093 8.8 KNG1 PLG SERPINE1

Biological processes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 C3 CRP KNG1 TLR5
2 positive regulation of angiogenesis GO:0045766 9.67 C3 F3 SERPINE1
3 negative regulation of endopeptidase activity GO:0010951 9.65 C3 KNG1 SERPINE1
4 platelet degranulation GO:0002576 9.58 KNG1 PLG SERPINE1
5 positive regulation of interleukin-8 production GO:0032757 9.51 SERPINE1 TLR5
6 fibrinolysis GO:0042730 9.46 PLG SERPINE1
7 blood coagulation GO:0007596 9.46 F11 F3 KNG1 PLG
8 blood coagulation, intrinsic pathway GO:0007597 9.37 F11 KNG1
9 negative regulation of blood coagulation GO:0030195 9.32 KNG1 SERPINE1
10 negative regulation of fibrinolysis GO:0051918 9.26 PLG SERPINE1
11 positive regulation of fibrinolysis GO:0051919 8.96 F11 PLG
12 hemostasis GO:0007599 8.92 F11 F3 KNG1 PLG

Molecular functions related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.26 C3 KNG1 PLG SERPINE1
2 serine-type endopeptidase activity GO:0004252 8.92 C3 F11 F3 PLG

Sources for Lemierre's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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