Lemierre's Syndrome

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Disease Ontology 12 DOID:11337 ICD9CM 36 040.3 MeSH 45 D005674 SNOMED-CT 69 52542005 MESH via Orphanet 46 D057831

ICD10 via Orphanet 35 I80.8 UMLS via Orphanet 75 C0343525 Orphanet 60 ORPHA137839 UMLS 74 C0016879 C0027537 C0343525

NIH Rare Diseases : ⁵⁴ Lemierre syndrome is a rare and potentially life-threatening complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection. The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum, although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to life-threatening complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs, and/or septic shock (in about 7% of cases). Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies. Because most throat infections in young, healthy people do not cause severe health problems, diagnosis and treatment may be delayed. The main treatment involves intravenous antibiotic therapy over several weeks, but surgery may be necessary when there is abscess formation, respiratory distress, or severe clotting in the chest or brain. The long-term outlook and chance of survival in people with Lemierre syndrome varies depending on how much the syndrome progresses, but even with appropriate treatment, it is fatal in some cases.

MalaCards based summary : Lemierre's Syndrome, also known as lemierre syndrome, is related to thrombosis and thrombophlebitis. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and Selenium Micronutrient Network. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lung and brain, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : ¹² A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia : ⁷⁷ Lemierre''s syndrome refers to infectious thrombophlebitis of the internal jugular vein. It most often... more...

Search NIH Clinical Center for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.