MCID: LMR001
MIFTS: 49

Lemierre's Syndrome

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Oral diseases, Rare diseases

Aliases & Classifications for Lemierre's Syndrome

MalaCards integrated aliases for Lemierre's Syndrome:

Name: Lemierre's Syndrome 12 77 15
Lemierre Syndrome 12 54 60 74
Postanginal Sepsis Secondary to Orophyngeal Infection 54 60
Septic Phlebitis of the Internal Jugular Vein 54 60
Lemierre Postanginal Sepsis 54 60
Fusobacterium Infections 45 74
Necrobacillosis 54 74
Oropharyngeal Infection Leading to Secondary Septic Thrombophlebitis of the Internal Jugular Vein 54
Human Necrobacillosis 12
Postanginal Sepsis 12
Acute Sore Throat 12

Characteristics:

Orphanet epidemiological data:

60
lemierre syndrome
Age of onset: Adolescent; Age of death: any age;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11337
ICD9CM 36 040.3
MeSH 45 D005674
SNOMED-CT 69 52542005
MESH via Orphanet 46 D057831
ICD10 via Orphanet 35 I80.8
UMLS via Orphanet 75 C0343525
Orphanet 60 ORPHA137839

Summaries for Lemierre's Syndrome

NIH Rare Diseases : 54 Lemierre syndrome is a rare and potentially life-threatening complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection. The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum, although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to life-threatening complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs, and/or septic shock (in about 7% of cases). Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies. Because most throat infections in young, healthy people do not cause severe health problems, diagnosis and treatment may be delayed. The main treatment involves intravenous antibiotic therapy over several weeks, but surgery may be necessary when there is abscess formation, respiratory distress, or severe clotting in the chest or brain. The long-term outlook and chance of survival in people with Lemierre syndrome varies depending on how much the syndrome progresses, but even with appropriate treatment, it is fatal in some cases.

MalaCards based summary : Lemierre's Syndrome, also known as lemierre syndrome, is related to thrombosis and thrombophlebitis. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia : 77 Lemierre''s syndrome refers to infectious thrombophlebitis of the internal jugular vein. It most often... more...

Related Diseases for Lemierre's Syndrome

Diseases related to Lemierre's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 thrombosis 31.1 F3 MTHFR SERPINE1
2 thrombophlebitis 30.8 MTHFR SERPINE1
3 mastoiditis 30.8 CRP MTHFR
4 thrombophilia due to thrombin defect 30.5 F3 MTHFR SERPINE1
5 mediastinitis 30.5 CRP DNM1
6 respiratory failure 30.3 ALB CRP F3
7 sphenoid sinusitis 30.3 CRP SLC25A16
8 fournier gangrene 30.1 ALB F3
9 thrombophilia 30.1 F11 F3 MTHFR SERPINE1
10 pulmonary embolism 29.8 ALB CRP F3 MTHFR SERPINE1
11 stroke, ischemic 29.5 CRP F3 MTHFR PLG SERPINE1
12 septic arthritis 29.5 CRP TLR5
13 systemic lupus erythematosus 29.4 ALB C3 CRP F3 TLR5
14 inferior vena cava interruption 10.4 MTHFR SERPINE1
15 neonatal stroke 10.4 MTHFR SERPINE1
16 amaurosis fugax 10.4 MTHFR SERPINE1
17 cryptogenic cirrhosis 10.4 MTHFR SERPINE1
18 acquired hemophilia 10.4 F11 F3
19 acquired hemophilia a 10.4 F11 F3
20 ischemic neuropathy 10.4 CRP MTHFR
21 testicular infarct 10.4 CRP MTHFR
22 marantic endocarditis 10.4 F3 MTHFR
23 alcohol-related birth defect 10.3 F11 F3
24 hepatic infarction 10.3 F3 MTHFR
25 conjugate gaze palsy 10.3 F3 PLG
26 cerebral falx meningioma 10.3 F3 PLG
27 carotid artery thrombosis 10.3 F3 SERPINE1
28 tuberculous empyema 10.3 PLG SERPINE1
29 leech infestation 10.3 F3 PLG
30 intestinal impaction 10.3 F3 PLG
31 giant hemangioma 10.3 F3 PLG
32 basilar artery occlusion 10.3 PLG SLC25A16
33 femoral neuropathy 10.3 F3 PLG
34 retinal vascular occlusion 10.3 MTHFR PLG
35 hemometra 10.3 F3 SLC25A16
36 ischemic heart disease 10.3 CRP MTHFR
37 factor xiii deficiency 10.3 F3 SERPINE1
38 acquired angioedema 10.3 C3 CRP
39 acute maxillary sinusitis 10.3 C3 CRP
40 pharyngitis 10.3
41 anterior cranial fossa meningioma 10.3 F3 PLG
42 korean hemorrhagic fever 10.3 F3 PLG
43 adult respiratory distress syndrome 10.3
44 acute cor pulmonale 10.3 PLG SERPINE1
45 buerger disease 10.3 MTHFR SERPINE1
46 catastrophic antiphospholipid syndrome 10.3 F3 MTHFR SERPINE1
47 acute pulmonary heart disease 10.3 PLG SERPINE1
48 intracranial hypertension 10.2 F3 MTHFR SERPINE1
49 carotid artery dissection 10.2 HOTAIR MTHFR PLG
50 blood protein disease 10.2 F3 MTHFR

Graphical network of the top 20 diseases related to Lemierre's Syndrome:



Diseases related to Lemierre's Syndrome

Symptoms & Phenotypes for Lemierre's Syndrome

MGI Mouse Phenotypes related to Lemierre's Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ALB ALK C3 CRP DNM1 F11
2 growth/size/body region MP:0005378 10.02 ALK C3 F11 F3 KNG1 MTHFR
3 cardiovascular system MP:0005385 10.01 C3 CRP DNM1 F11 F3 PLG
4 mortality/aging MP:0010768 9.85 ALB ALK C3 DNM1 F11 F3
5 liver/biliary system MP:0005370 9.8 ALB C3 F11 MTHFR PLG SERPINE1
6 neoplasm MP:0002006 9.35 ALB ALK F3 PLG SERPINE1
7 respiratory system MP:0005388 9.1 ALK F11 F3 PLG SERPINE1 TLR5

Drugs & Therapeutics for Lemierre's Syndrome

Drugs for Lemierre's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Microbiology of Para- og Retropharyngeal Abscess Recruiting NCT02640456

Search NIH Clinical Center for Lemierre's Syndrome

Cochrane evidence based reviews: fusobacterium infections

Genetic Tests for Lemierre's Syndrome

Anatomical Context for Lemierre's Syndrome

MalaCards organs/tissues related to Lemierre's Syndrome:

42
Heart, Lung, Kidney, Tonsil, Liver, Brain, Spleen

Publications for Lemierre's Syndrome

Articles related to Lemierre's Syndrome:

(show top 50) (show all 478)
# Title Authors Year
1
Lemierre's syndrome: a case study with a short review of literature. ( 29783881 )
2019
2
Lemierre's syndrome: A forgotten complication of acute pharyngitis. ( 30291034 )
2019
3
Fatal Fusobacterium necrophorum infection with gynecological Lemierre's syndrome. ( 30309662 )
2019
4
Lemierre's syndrome: One rare disease-Two case studies. ( 30484880 )
2019
5
Complete Genome Sequences of Two Isolates of Fusobacterium necrophorum subsp. funduliforme, Obtained from Blood from Patients with Lemierre's Syndrome. ( 30701252 )
2019
6
Surgical Management of Descending Necrotizing Mediastinitis Complicated by Purulent Pericarditis and Lemierre's Syndrome. ( 30760372 )
2019
7
Antibiotic and Anticoagulation Therapy in Lemierre's Syndrome: Case Report and Review. ( 30773133 )
2019
8
Mastoiditis with concomitant Lemierre's syndrome: A case report. ( 30786966 )
2019
9
Lemierre's Syndrome. ( 30893539 )
2019
10
Lemierre's syndrome: a disguised threat. ( 31015242 )
2019
11
"A prostatic Lemierre syndrome". ( 31075506 )
2019
12
AN UNUSUAL CAUSE OF LEMIERRE SYNDROME. ( 30772450 )
2019
13
Rare and life-threatening complication after an attempted lower third molar extraction: Lemierre syndrome. ( 30372118 )
2019
14
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. ( 30071559 )
2019
15
An Unusual Presentation of Nasopharyngeal Carcinoma as Lemierre Syndrome. ( 30814483 )
2019
16
Lemierre's syndrome presented with acute pancreatitis. ( 29657730 )
2018
17
Sore Throat, Fever, Septic Emboli, and Acute Respiratory Distress Syndrome: A Case of Lemierre Syndrome. ( 30631607 )
2018
18
Atypical Presentation of Lemierre's Syndrome Causing Septic Shock and Acute Respiratory Distress Syndrome. ( 30057835 )
2018
19
Brugada syndrome in a 4-year-old child with Lemierre syndrome-A case report. ( 29910587 )
2018
20
Lemierre Syndrome in Adolescent with Active Ulcerative Colitis. ( 29992123 )
2018
21
Utility of PET scan in diagnosis and monitoring descending necrotizing mediastinitis complicating Lemierre's syndrome. ( 28776174 )
2018
22
Bacterial Arthritis of the Hip Due to Lemierre Syndrome: A Case Report. ( 30431478 )
2018
23
Lemierre's Syndrome Presenting as Multifocal Pyomyositis in a Young Child. ( 28877155 )
2018
24
Lemierre's syndrome: a pain in the neck with far-reaching consequences. ( 29298792 )
2018
25
Lesson of the month 1: Lemierre's syndrome: a reminder of the 'forgotten disease'. ( 29436449 )
2018
26
A Case of Lemierre's Syndrome in Intensive Care Unit. ( 29531456 )
2018
27
Lemierre's syndrome following perianal abscess: A case report. ( 29573596 )
2018
28
Lemierre's syndrome: cavitary lung disease caused by uncommon bacteria. ( 29669776 )
2018
29
Lemierre's syndrome: a rare cause of sepsis presenting with an absence of throat symptoms. ( 29705735 )
2018
30
Lemierre's syndrome: A persistent unusual neck pain and swelling. ( 29796209 )
2018
31
Lemierre's syndrome leading to cerebral venous thrombosis. ( 29898085 )
2018
32
Acute parotitis due to MRSA causing Lemierre's syndrome. ( 29942528 )
2018
33
The co-existence of Lemierre's syndrome and Bezold's abscesses due to Streptococcus constellatus: A case report. ( 29952983 )
2018
34
Lemierre's syndrome and 2016 American College of Physician guidelines for pharyngitis: no to empiric coverage for bacterial pharyngitis. While no role for routine Fusobacterium PCR, keep suspicion for this pathogen. ( 30030249 )
2018
35
Cone beam computed tomography-guided transpterygoidal aspiration of a carotid space abscess in Lemierre's syndrome. ( 30042808 )
2018
36
Lemierre's Syndrome in an Aseptic Patient with Systemic Lupus Erythematosus. ( 30109797 )
2018
37
Purpura fulminans with Lemierre's syndrome caused by Gemella bergeri and Eikenella corrodens: a case report. ( 30340466 )
2018
38
Lemierre's syndrome: a life-threatening sore throat. ( 30368479 )
2018
39
Lemierre's Syndrome. ( 30410696 )
2018
40
A case of Lemierre's syndrome with disturbed venous flow confirmed by conventional angiography. ( 30504581 )
2018
41
Intravascular abscess in Lemierre's syndrome due to meticillin-sensitive Staphylococcus aureus. ( 30507410 )
2018
42
Porphyromonas asaccharolytica as a Rare Causative Agent for Lemierre's Syndrome. ( 30533234 )
2018
43
Unusual case of Lemierre's syndrome. ( 30567118 )
2018
44
Senile Lemierre syndrome complicated with descending necrotizing mediastinitis: A case report. ( 30170383 )
2018
45
Fissuration of vertebral artery mycotic aneurysm due to Lemierre syndrome. ( 28652095 )
2018
46
Neonatal Lemierre Syndrome: Youngest Reported Case and Literature Review. ( 28719983 )
2018
47
Lemierre syndrome: case report. ( 30787954 )
2018
48
INTRAOCULAR JARISCH-HERXHEIMER REACTION IN LEMIERRE SYNDROME. ( 30074939 )
2018
49
Lemierre Syndrome as a Complication of Laryngeal Carcinoma. ( 29849275 )
2018
50
Septic thrombosis of cavernous sinus extended to the ipsilateral internal jugular vein and transversal sinus with favorable outcome: Clinical and radiological features of a Lemierre syndrome. ( 29040036 )
2018

Variations for Lemierre's Syndrome

Expression for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.

Pathways for Lemierre's Syndrome

GO Terms for Lemierre's Syndrome

Cellular components related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 ALB C3 CRP F11 F3 KNG1
2 extracellular exosome GO:0070062 9.86 ALB ALK C3 DNM1 F11 KNG1
3 extracellular space GO:0005615 9.76 ALB C3 CRP F11 F3 KNG1
4 collagen-containing extracellular matrix GO:0062023 9.67 F3 KNG1 PLG SERPINE1
5 blood microparticle GO:0072562 9.26 ALB C3 KNG1 PLG
6 platelet alpha granule lumen GO:0031093 8.92 ALB KNG1 PLG SERPINE1

Biological processes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.76 C3 CRP KNG1 TLR5
2 positive regulation of angiogenesis GO:0045766 9.69 C3 F3 SERPINE1
3 negative regulation of endopeptidase activity GO:0010951 9.65 C3 KNG1 SERPINE1
4 cellular protein metabolic process GO:0044267 9.62 ALB C3 KNG1 PLG
5 blood coagulation GO:0007596 9.56 F11 F3 KNG1 PLG
6 positive regulation of interleukin-8 production GO:0032757 9.52 SERPINE1 TLR5
7 fibrinolysis GO:0042730 9.49 PLG SERPINE1
8 blood coagulation, intrinsic pathway GO:0007597 9.43 F11 KNG1
9 negative regulation of blood coagulation GO:0030195 9.4 KNG1 SERPINE1
10 negative regulation of fibrinolysis GO:0051918 9.37 PLG SERPINE1
11 platelet degranulation GO:0002576 9.26 ALB KNG1 PLG SERPINE1
12 positive regulation of fibrinolysis GO:0051919 9.16 F11 PLG
13 hemostasis GO:0007599 8.92 F11 F3 KNG1 PLG

Molecular functions related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.26 C3 KNG1 PLG SERPINE1
2 serine-type endopeptidase activity GO:0004252 8.8 F11 F3 PLG

Sources for Lemierre's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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