MCID: LMR001
MIFTS: 39

Lemierre's Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Lemierre's Syndrome

MalaCards integrated aliases for Lemierre's Syndrome:

Name: Lemierre's Syndrome 12 73 20 15
Lemierre Syndrome 12 20 58 70
Postanginal Sepsis Secondary to Orophyngeal Infection 20 58
Septic Phlebitis of the Internal Jugular Vein 20 58
Lemierre Postanginal Sepsis 20 58
Fusobacterium Infections 44 70
Necrobacillosis 20 70
Oropharyngeal Infection Leading to Secondary Septic Thrombophlebitis of the Internal Jugular Vein 20
Human Necrobacillosis 12
Postanginal Sepsis 12
Acute Sore Throat 12

Characteristics:

Orphanet epidemiological data:

58
lemierre syndrome
Age of onset: Adolescent; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11337
ICD9CM 34 040.3
MeSH 44 D005674
SNOMED-CT 67 52542005
MESH via Orphanet 45 D057831
ICD10 via Orphanet 33 I80.8
UMLS via Orphanet 71 C0343525
Orphanet 58 ORPHA137839
UMLS 70 C0016879 C0027537 C0343525

Summaries for Lemierre's Syndrome

GARD : 20 Lemierre syndrome is a rare and potentially life-threatening complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection. The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum, although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to life-threatening complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs, and/or septic shock (in about 7% of cases). Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies. Because most throat infections in young, healthy people do not cause severe health problems, diagnosis and treatment may be delayed. The main treatment involves intravenous antibiotic therapy over several weeks, but surgery may be necessary when there is abscess formation, respiratory distress, or severe clotting in the chest or brain. The long-term outlook and chance of survival in people with Lemierre syndrome varies depending on how much the syndrome progresses, but even with appropriate treatment, it is fatal in some cases.

MalaCards based summary : Lemierre's Syndrome, also known as lemierre syndrome, is related to thrombophlebitis and thrombosis. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways is Selenium Micronutrient Network. The drugs Menthol and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, spleen and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia : 73 Lemierre's syndrome refers to infectious thrombophlebitis of the internal jugular vein. It most often... more...

Related Diseases for Lemierre's Syndrome

Diseases related to Lemierre's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 359)
# Related Disease Score Top Affiliating Genes
1 thrombophlebitis 31.0 MTHFR F3 F2 CRP
2 thrombosis 30.7 MTHFR F3 F2
3 pleural empyema 30.7 F2 CRP
4 mastoiditis 30.5 MTHFR F2 CRP
5 cavernous sinus thrombosis 30.4 F3 F2 CRP
6 respiratory failure 30.3 F3 F2 CRP
7 pulmonary embolism 30.3 MTHFR F3 F2 CRP
8 cellulitis 30.2 F3 F2 CRP
9 disseminated intravascular coagulation 30.2 F3 F2 CRP
10 mediastinitis 30.2 F3 F2 CRP
11 thrombophilia 30.1 MTHFR F3 F2
12 leptospirosis 30.1 F2 CRP
13 lateral sinus thrombosis 30.1 MTHFR F2
14 epiglottitis 30.0 SUCLG2 CRP
15 epidural abscess 30.0 F3 F2 CRP
16 bilirubin metabolic disorder 30.0 F3 F2 CRP
17 intracranial thrombosis 29.9 MTHFR F3 F2
18 mycoplasma pneumoniae pneumonia 29.9 F3 CRP
19 hemarthrosis 29.9 F3 F2
20 subdural empyema 29.9 F2 CRP ACR
21 purpura fulminans 29.9 F3 F2
22 cardiac tamponade 29.9 F3 F2 CRP
23 purpura 29.9 F3 F2 CRP
24 carotid stenosis 29.8 MTHFR CRP
25 bronchopneumonia 29.8 F3 CRP ACR
26 portal vein thrombosis 29.7 MTHFR F2 CRP
27 thrombophilia due to activated protein c resistance 29.7 MTHFR F3 F2
28 budd-chiari syndrome 29.7 MTHFR F3 F2
29 thrombophilia due to thrombin defect 29.7 MTHFR F3 F2
30 hemopericardium 29.7 F3 F2 CRP
31 tricuspid valve insufficiency 29.7 F3 F2 CRP
32 pericardial effusion 29.6 F3 F2 CRP
33 exanthem 29.6 F3 F2 CRP
34 thrombocytopenia 29.6 MTHFR F3 F2 CRP
35 antiphospholipid syndrome 29.4 MTHFR F3 F2 CRP
36 patent foramen ovale 29.4 MTHFR F3 F2 CRP
37 stroke, ischemic 29.4 MTHFR F3 F2 CRP
38 myocardial infarction 29.4 MTHFR F3 F2 CRP
39 inflammatory bowel disease 29.1 MTHFR F3 F2 CRP
40 pharyngitis 10.7
41 tonsillitis 10.6
42 toxic shock syndrome 10.5
43 septic arthritis 10.4
44 osteomyelitis 10.3
45 adult respiratory distress syndrome 10.3
46 otitis media 10.3
47 acute kidney failure 10.3
48 dysphagia 10.3
49 fasciitis 10.2
50 catastrophic antiphospholipid syndrome 10.2 MTHFR F3

Graphical network of the top 20 diseases related to Lemierre's Syndrome:



Diseases related to Lemierre's Syndrome

Symptoms & Phenotypes for Lemierre's Syndrome

GenomeRNAi Phenotypes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.81 SUCLG2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.81 ACR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.81 MTHFR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.81 ACR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.81 MTHFR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.81 F2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.81 MTHFR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.81 F2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.81 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.81 ACR
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.81 MTHFR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.81 CRP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.81 MTHFR
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.81 MTHFR CRP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.81 MTHFR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.81 ACR
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.81 MTHFR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.81 CRP
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.81 MTHFR
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.81 MTHFR

Drugs & Therapeutics for Lemierre's Syndrome

Drugs for Lemierre's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2 Dermatologic Agents Phase 4
3
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 9552079 2713
4
Benzydamine Approved Phase 3 642-72-8, 100-46-9 7504
5
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
6
Ibuprofen Approved Phase 3 15687-27-1 3672
7
Sage Approved Phase 3
8
Echinacea Approved, Experimental Phase 3
9 Chlorhexidine gluconate Phase 3
10 Pharmaceutical Solutions Phase 3
11 Muramidase Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 3
14 Antirheumatic Agents Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Analgesics Phase 3
17 Analgesics, Non-Narcotic Phase 3
18 Sodium Channel Blockers Phase 3
19 Anti-Arrhythmia Agents Phase 3
20 Anti-Infective Agents, Local Phase 3
21 Diuretics, Potassium Sparing Phase 3
22 Anesthetics Phase 3
23 Anesthetics, Local Phase 3
24 Disinfectants Phase 3
25 Anti-Infective Agents Phase 3
26
Flurbiprofen Approved, Investigational Phase 2 5104-49-4 3394
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 68-26-8, 11103-57-4 445354
28 Retinol palmitate Phase 2
29 retinol Phase 2
30
Thyme Approved
31 Propolis
32 Bee Products

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Clinical Trial to Assess Safety and Efficacy of the Sore Throat Lozenges in Patients With Acute Sore Throats Active, not recruiting NCT04139681 Phase 4 A. Vogels Sore Throat lozenges
2 A Multicenter, Single-blind, Randomized, Placebo-controlled Comparative Study on Efficacy and Safety of the Lysobact Complete Spray®, Tantum Verde® Spray and Pharyngal® Oromucosal Spray in the Treatment of Acute Sore Throat in Common Cold Completed NCT03282045 Phase 3 Lysobact Complete Sprey;Tantum Verde® Spray;Pharyngal® Oromucosal Spray;Placebo
3 Study of Efficacy and Safety of V0498 Versus Placebo in Acute Sore Throat Pain. Completed NCT01785862 Phase 3 Ibuprofen 25 mg;Placebo
4 Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats Completed NCT00707902 Phase 3 chlorhexidine/lidocaine;echinacea/sage
5 Analgesic Profile of 3 New Ibuprofen Lozenges (V0498TA01A 15 mg, 25 mg, 35 mg) After Single Administration in Acute Sore Throat Pain Completed NCT01535079 Phase 2 Placebo;Ibuprofen 35 mg;Ibuprofen 25 mg;Ibuprofen 15 mg;Strefen
6 Efficacy of Natural Seawater Based Throat Spray in Acute Sore Throat Relief: a Prospective, Randomized, Double-blind, Placebo-controlled, Multicentre Clinical Study Unknown status NCT03369132
7 Ear Acupuncture for Acute Sore Throat. A Randomized Controlled Trial. Completed NCT01302769
8 Ear Acupuncture for Acute Sore Throat in Patients Unable to Take Non-steroidal Anti-inflammatory Agents (NSAIDs) Terminated NCT01301482

Search NIH Clinical Center for Lemierre's Syndrome

Cochrane evidence based reviews: fusobacterium infections

Genetic Tests for Lemierre's Syndrome

Anatomical Context for Lemierre's Syndrome

MalaCards organs/tissues related to Lemierre's Syndrome:

40
Brain, Spleen, Heart, Lung, Kidney, Uterus, Tongue

Publications for Lemierre's Syndrome

Articles related to Lemierre's Syndrome:

(show top 50) (show all 795)
# Title Authors PMID Year
1
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. 20 61
30071559 2019
2
[Lemierre's syndrome: Diagnosis, exploration, treatment]. 61 20
29269194 2018
3
The long shadow of lemierre's syndrome. 20 61
28646962 2017
4
Fusobacterial head and neck infections in children. 20 61
25980688 2015
5
Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review. 20 61
23845534 2013
6
Infections of the Neck. 20
30454783 2019
7
Anticoagulation Strategies in the Management of Lemierre Syndrome: A Systematic Review of the Literature. 61
32909436 2021
8
Sex differences in Lemierre syndrome: Individual patient-level analysis. 61
33713865 2021
9
Lemierre syndrome - treat with antibiotics, anticoagulants or both? 61
32419246 2021
10
Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases. 61
32445216 2021
11
IJV thrombophlebitis: be wary of the occult. 61
33731404 2021
12
Lemierre's syndrome with cavernous sinus thrombosis caused by dental infection. 61
33727287 2021
13
Forget-me-not: Lemierre's syndrome, a case report. 61
33760711 2021
14
Fusobacterium necrophorum-induced orbital cellulitis with intracranial involvement: a case report and review of the literature. 61
33682595 2021
15
Atypical Lemierre's syndrome complicated by transcalvarial brain herniation. 61
33599998 2021
16
A 16-year-old with Lemierre's syndrome and multiple septic pulmonary emboli. 61
33270999 2021
17
Internal Jugular Vein and Cerebral Venous Sinus Infective Thrombophlebitis Detected With 99mTc-HMPAO White Blood Cell Scintigraphy. 61
33156045 2021
18
Internal Jugular Vein Thrombosis: Etiology, Symptomatology, Diagnosis and Current Treatment. 61
33672254 2021
19
Jugular Vein Thrombosis and Anticoagulation Therapy in Lemierre's Syndrome-A Post Hoc Observational and Population-Based Study of 82 Patients. 61
33447643 2021
20
Lemierre Syndrome: Unusual Presentation With Superior Ophthalmic Vein Thrombosis. 61
33405462 2021
21
A rare, but life-threatening sore throat: A case of Lemierre's syndrome. 61
33749697 2021
22
Is the term "anti-anaerobic" still relevant? 61
33127500 2021
23
Lemierre's Syndrome with Severe Thrombocytopenia without Disseminated Intravascular Coagulation: A Case Report and Literature Review. 61
33681457 2021
24
An Atypical Presentation of Lemierre's Syndrome: Complicated by Thrombotic Thrombocytopenic Purpura. 61
33614331 2021
25
Reader comments: Chest surgery in Lemierre syndrome. 61
33678984 2021
26
Septic Pulmonary Embolism Secondary to Lemierre Syndrome. 61
33454173 2021
27
Lemierre's syndrome or re-emerging disease: Case report and literature review. 61
33352443 2021
28
Infectious Brachial Plexopathy and Septic Arthritis of the Shoulder due to Lemierre's Syndrome: A Case Report and Literature Review. 61
33439602 2020
29
A Case of Lemierre Syndrome in the Era of COVID-19: All That Glitters Is Not Gold. 61
33003102 2020
30
Lemierre syndrome: Current evidence and rationale of the Bacteria-Associated Thrombosis, Thrombophlebitis and LEmierre syndrome (BATTLE) registry. 61
33091703 2020
31
Management of pediatric head and neck infections in the emergency department. 61
33105074 2020
32
Lemierre's syndrome involving milleri group streptococci: further insight into age and aetiology. 61
33229487 2020
33
A case of septic arthritis of the temporomandibular joint with necrotic peri-articular infection and Lemierre's syndrome: an unusual presentation. 61
33151408 2020
34
Lemierre's Syndrome Following Extraction of Wisdom Teeth. 61
33224657 2020
35
Late presentation of 'Lemierre's syndrome': how a delay in seeking healthcare and reduced access to routine services resulted in widely disseminated Fusobacterium necrophorum infection during the global COVID-19 pandemic. 61
33040042 2020
36
Bacteremia and sepsis by Arcanobacterium haemolyticum in a young immunocompetent patient. 61
32201068 2020
37
Lemierre's syndrome: a forgotten life-threatening entity. 61
33127694 2020
38
Lemierre's Syndrome: Case Report Of 'The Forgotten Disease' In Current Covid-19 Pandemic. 61
33280320 2020
39
[Cervicofacial cellulitis complicated by internal jugular vein thrombosis]. 61
32505376 2020
40
Corrigendum to "Lemierre's syndrome in an acute myocardial infarction patient" [J Microbiol Immunol Infect 53 (1) (2020 Feb) 186-187]. 61
32839119 2020
41
Lemierre's syndrome in the pediatric population: Trends in disease presentation and management in literature. 61
32797805 2020
42
A teenager with fever, chest pain, and respiratory distress during the coronavirus disease 2019 pandemic: a lesson on anchoring bias. 61
33043318 2020
43
Unilateral proptosis in Lemierre's syndrome variant. 61
32546572 2020
44
A 4-year-old boy with Lemierre's syndrome caused by methicillin-sensitive Staphylococcus aureus. 61
32507402 2020
45
A Challenging Case of Lemierre's Syndrome With Central Nervous System Involvement and a Comprehensive Review. 61
32879837 2020
46
A Rare Case Report of Lemierre Syndrome from the Anterior Jugular Vein. 61
32926711 2020
47
Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment. 61
32726825 2020
48
Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome: an 8-year Swedish nationwide retrospective study. 61
31843654 2020
49
A unique case of Lemierre's syndrome status post blunt cervical trauma. 61
32228176 2020
50
Lemierre's syndrome: A forgotten and re-emerging infection. 61
32303484 2020

Variations for Lemierre's Syndrome

Expression for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.

Pathways for Lemierre's Syndrome

Pathways related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 MTHFR F2 CRP

GO Terms for Lemierre's Syndrome

Biological processes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemostasis GO:0007599 8.96 F3 F2
2 acute-phase response GO:0006953 8.62 F2 CRP

Molecular functions related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F3 F2 ACR

Sources for Lemierre's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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