MCID: LMR001
MIFTS: 42

Lemierre's Syndrome

Categories: Infectious diseases, Rare diseases
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Aliases & Classifications for Lemierre's Syndrome

MalaCards integrated aliases for Lemierre's Syndrome:

Name: Lemierre's Syndrome 11 19 75 14
Lemierre Syndrome 11 19 58 71
Postanginal Sepsis Secondary to Orophyngeal Infection 19 58
Septic Phlebitis of the Internal Jugular Vein 19 58
Lemierre Postanginal Sepsis 19 58
Fusobacterium Infections 43 71
Necrobacillosis 19 71
Oropharyngeal Infection Leading to Secondary Septic Thrombophlebitis of the Internal Jugular Vein 19
Human Necrobacillosis 11
Postanginal Sepsis 11
Acute Sore Throat 11

Characteristics:


Prevelance:

Lemierre Syndrome: 1-5/10000 (Denmark) 58

Age Of Onset:

Lemierre Syndrome: Adolescent 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 11 DOID:11337
ICD9CM 34 040.3
MeSH 43 D005674
SNOMED-CT 68 52542005
MESH via Orphanet 44 D057831
ICD10 via Orphanet 32 J03.8
UMLS via Orphanet 72 C0343525
Orphanet 58 ORPHA137839
UMLS 71 C0016879 C0027537 C0343525

Summaries for Lemierre's Syndrome

GARD: 19 Lemierre syndrome is a rare and potentially severe complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection. The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum, although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to severe complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs, and/or septic shock (in about 7% of cases). Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies.

MalaCards based summary: Lemierre's Syndrome, also known as lemierre syndrome, is related to toxic shock syndrome and thrombophlebitis. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Defects of contact activation system (CAS) and kallikrein/kinin system (KKS). The drugs Benzydamine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spleen, lung and brain.

Orphanet: 58 Lemierre syndrome is a rare, potentially lethal, oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to Fusobacterium necrophorum and that is characterized by septic thrombophlebitis of the internal jugular vein that leads to septic, usually pulmonary, embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain, and tonsillopharyngitis.

Disease Ontology: 11 A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia: 75 Lemierre's syndrome is infectious thrombophlebitis of the internal jugular vein. It most often develops... more...

Related Diseases for Lemierre's Syndrome

Diseases related to Lemierre's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 442)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 30.7 SERPINC1 F3 CRP
2 thrombophlebitis 30.7 SERPINC1 PLG F3 F2 CRP
3 thrombophilia due to thrombin defect 30.6 SERPINC1 F3 F2
4 pleural empyema 30.4 PLG F2 CRP
5 subdural empyema 30.4 F2 CRP
6 horner's syndrome 30.4 F3 CRP
7 pulmonary embolism 30.4 SERPINC1 F3 F2 CRP
8 cellulitis 30.3 F3 F2 CRP
9 mediastinitis 30.3 F3 F2 CRP
10 epiglottitis 30.3 SUCLG2 SIGLEC5 CRP
11 epidural abscess 30.2 F3 F2 CRP
12 mastoiditis 30.2 SERPINC1 F3 F2 CRP
13 thrombosis 30.2 SERPINC1 PLG F3 F2
14 cavernous sinus thrombosis 30.2 SERPINC1 F3 F2 CRP
15 angina pectoris 30.1 F3 CRP
16 intracranial abscess 30.1 MORN2 CRP
17 pericoronitis 30.1 F3 CRP
18 salpingitis 30.1 SIGLEC5 CRP
19 cranial nerve palsy 30.0 SERPINC1 F2 CRP
20 thrombophilia 30.0 SERPINC1 F3 F2
21 endophthalmitis 30.0 PLG CRP
22 polycythemia 30.0 F3 F2 CRP
23 lateral sinus thrombosis 29.9 SERPINC1 F2
24 abducens palsy 29.9 SERPINC1 F2 CRP
25 vitamin k deficiency bleeding 29.9 SERPINC1 F3 F2
26 necrotizing fasciitis 29.9 PLG F3 F2 CRP
27 thrombocytopenia 29.8 SERPINC1 F3 F2 CRP
28 respiratory failure 29.8 SERPINC1 PLG F3 F2 CRP
29 bilirubin metabolic disorder 29.8 SERPINC1 F3 F2 CRP
30 tricuspid valve insufficiency 29.8 F3 F2 CRP
31 anuria 29.8 F3 F2 CRP
32 pericardial effusion 29.8 F3 F2 CRP
33 exanthem 29.8 F3 F2 CRP
34 urinary tract infection 29.8 F3 F2 CRP
35 heart valve disease 29.7 F3 F2 CRP
36 endocarditis 29.7 SERPINC1 F2 CRP
37 bacterial sepsis 29.7 SERPINC1 F3 CRP
38 disseminated intravascular coagulation 29.7 SERPINC1 PLG F3 F2 CRP
39 hemarthrosis 29.6 SERPINC1 F3 F2
40 factor xii deficiency 29.6 SERPINC1 F3 F2
41 vascular disease 29.6 SERPINC1 F3 F2 CRP
42 cardiac tamponade 29.6 PLG F3 F2 CRP
43 purpura 29.6 SERPINC1 F3 F2 CRP
44 carotid artery thrombosis 29.6 SERPINC1 PLG F3
45 polycythemia vera 29.6 SERPINC1 F3 F2 CRP
46 acute myocardial infarction 29.6 SERPINC1 F3 F2 CRP
47 antiphospholipid syndrome 29.4 SERPINC1 F3 F2 CRP
48 portal vein thrombosis 29.4 SERPINC1 PLG F3 F2 CRP
49 behcet syndrome 29.4 SERPINC1 F3 F2 CRP
50 thrombophilia due to activated protein c resistance 29.3 SERPINC1 PLG F3 F2

Graphical network of the top 20 diseases related to Lemierre's Syndrome:



Diseases related to Lemierre's Syndrome

Symptoms & Phenotypes for Lemierre's Syndrome

Drugs & Therapeutics for Lemierre's Syndrome

Drugs for Lemierre's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzydamine Approved Phase 4 642-72-8 12555
2 Pharmaceutical Solutions Phase 4
3
Ibuprofen Approved Phase 3 15687-27-1 3672
4
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 3 55-56-1 2713 9552079
5
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
6 Analgesics Phase 3
7 Antirheumatic Agents Phase 3
8 Cyclooxygenase Inhibitors Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Muramidase Phase 3
11 Chlorhexidine gluconate Phase 3
12
Flurbiprofen Approved, Investigational Phase 2 5104-49-4 3394
13
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 68-26-8 5280382 445354
14 Retinol palmitate Phase 2
15
Thyme Approved
16 Bee Products
17 Propolis
18 Anti-Inflammatory Agents
19 Anti-Inflammatory Agents, Non-Steroidal

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase IV Study Comparing the Efficacy and Safety of Benzydamine Hydrochloride 0,3% Oromucosal Spray and Benzydamine Hydrochloride 3 mg Lozenges in Patients With Acute Sore Throat Completed NCT04941976 Phase 4 0.3% benzydamine hydrochloride spray oromucosal solution;Single 3 mg lozenge of benzydamine hydrochloride (mint flavour)
2 Study of Efficacy and Safety of V0498 Versus Placebo in Acute Sore Throat Pain. Completed NCT01785862 Phase 3 Ibuprofen 25 mg;Placebo
3 A Multicenter, Single-blind, Randomized, Placebo-controlled Comparative Study on Efficacy and Safety of the Lysobact Complete Spray®, Tantum Verde® Spray and Pharyngal® Oromucosal Spray in the Treatment of Acute Sore Throat in Common Cold Completed NCT03282045 Phase 3 Lysobact Complete Sprey;Tantum Verde® Spray;Pharyngal® Oromucosal Spray;Placebo
4 Analgesic Profile of 3 New Ibuprofen Lozenges (V0498TA01A 15 mg, 25 mg, 35 mg) After Single Administration in Acute Sore Throat Pain Completed NCT01535079 Phase 2 Placebo;Ibuprofen 35 mg;Ibuprofen 25 mg;Ibuprofen 15 mg;Strefen
5 Efficacy of Natural Seawater Based Throat Spray in Acute Sore Throat Relief: a Prospective, Randomized, Double-blind, Placebo-controlled, Multicentre Clinical Study Unknown status NCT03369132
6 Ear Acupuncture for Acute Sore Throat. A Randomized Controlled Trial. Completed NCT01302769
7 Ear Acupuncture for Acute Sore Throat in Patients Unable to Take Non-steroidal Anti-inflammatory Agents (NSAIDs) Terminated NCT01301482

Search NIH Clinical Center for Lemierre's Syndrome

Cochrane evidence based reviews: fusobacterium infections

Genetic Tests for Lemierre's Syndrome

Anatomical Context for Lemierre's Syndrome

Organs/tissues related to Lemierre's Syndrome:

MalaCards : Spleen, Lung, Brain, Liver, Kidney, Heart, Tonsil

Publications for Lemierre's Syndrome

Articles related to Lemierre's Syndrome:

(show top 50) (show all 1199)
# Title Authors PMID Year
1
Lemierre's syndrome: should neck imaging be performed in all young patients with cavitating pneumonia? 62
36468618 2022
2
High risk and low prevalence diseases: Lemierre's syndrome. 62
36058204 2022
3
Atypical involvement of the thyro-linguo-facial vein in Lemierre syndrome. 62
36379635 2022
4
Septic Pulmonary Embolism. A Contemporary Profile. 62
36417928 2022
5
International Delphi-based consensus on the appropriate use and effect of Benzydamine hydrochloride in the treatment of sore throat. 62
36419002 2022
6
[Acute sore throat, not always innocent]. 62
36300468 2022
7
Lemierre's Syndrome: A Lethal Complication of Acute Tonsillitis. 62
36381870 2022
8
Lemierre's syndrome with cranial epidural abscess complication: A case report. 62
36147177 2022
9
Lemierre syndrome associated mycotic cavernous sinus thrombosis and carotid aneurysm after COVID-19. 62
35782172 2022
10
Lemierre's Syndrome as a Sexually Transmitted Disease Due to Porphyromonas asaccharolytica Suspected to Be Caused by Pharyngitis Due to Mycoplasma pneumoniae and Epstein-Barr Virus. 62
36158393 2022
11
Portal Vein Thrombosis Associated With Fusobacterium nucleatum Bacteremia: A Rare Abdominal Variant of Lemierre's Syndrome. 62
36120206 2022
12
Fusobacterium necrophorum-induced orbital cellulitis with intracranial involvement: a case report and review of the literature. 62
33682595 2022
13
Cardiac and Cerebral Arterial Complications of Lemierre Syndrome: Results from a Systematic Review and Individual Patient Data Meta-analysis. 62
35255510 2022
14
Atypical presentation of Lemierre syndrome in a young healthy man with acute jaundice. 62
36129352 2022
15
Lemierre's syndrome: case report of "the forgotten disease" in current COVID-19 pandemic. 62
35780408 2022
16
Lemierre's Syndrome: A Comeback Story. 62
35832767 2022
17
Fusobacterium Necrophorum Septicemia Secondary to an Ovarian Abscess: A Case Report. 62
35859958 2022
18
Fusobacterium necrophorum oral infections - A need for guidance. 62
35122953 2022
19
Septic Thrombophlebitis of the Internal Jugular Vein in an Immunocompromised Patient with Lemierre Syndrome: A Case Report. 62
35688768 2022
20
[Lemierre's syndrome: a rare disease, but not forgotten]. 62
35736354 2022
21
An Unusual Etiology of Lemierre-Like Syndrome: Preseptal Cellulitis due to Methicillin-Resistant Staphylococcus aureus. 62
35531375 2022
22
Lemierre Syndrome Complicating Deep Neck Infection and Descending Mediastinitis Secondary to Methicillin resistant Staphylococcus aureus (MRSA) Infection. 62
35799738 2022
23
Expression of Concern: Lemierre's Syndrome: A Case of Life-Threatening Infection From Family Medicine Practice. 62
35463596 2022
24
Erratum to: EP.FRI.147 Abdominal Variant Lemierre's Syndrome: A Case Study and literature review. 62
34935875 2022
25
What is the optimal strategy for managing primary care patients with an uncomplicated acute sore throat? Comparing the consequences of nine different strategies using a compilation of previous studies. 62
35487741 2022
26
Factors Affecting Patients with Concurrent Deep Neck Infection and Lemierre's Syndrome. 62
35453976 2022
27
Lemierre syndrome with brain abscesses located in watershed regions. Clinical report. 62
34973901 2022
28
[Odontogenic cervical-facial cellulitis: report of 87 cases]. 62
35258867 2022
29
A Complex Case of Lemierre's Syndrome With Facial Vein Involvement. 62
35475072 2022
30
Use of antibiotics for acute sore throat and tonsillitis in primary care. 62
35210250 2022
31
Lemierre's syndrome masking metastatic lung adenocarcinoma. 62
34996853 2022
32
Use of intravascular hypo- and hyper-attenuation on non-contrast-enhanced computed tomography in diagnosing acute septic thrombophlebitis. 62
35529424 2022
33
Retinal, Optic Nerve, and Cerebral Infarction in Odontogenic Lemierre Syndrome. 62
34334758 2022
34
A case of Lemierre's syndrome with double vision as the first symptom. 62
34598877 2022
35
Lemierre's syndrome complicated by cerebral venous sinus thrombosis: A life threatening and rare disease successfully treated with empiric antimicrobial therapy and conservative approach. 62
35261851 2022
36
Short blood culture time-to-positivity in Fusobacterium necrophorum bacteremia is associated with Lemierre's syndrome. 62
34758377 2022
37
Ophthalmic complications of Lemierre syndrome. 62
33829646 2022
38
Lemierre Syndrome. 62
35600760 2022
39
Self-sampling to identify pathogens and inflammatory markers in patients with acute sore throat: Feasibility study. 62
36275691 2022
40
Case report of atypical Lemierre's Syndrome associated with Fusobacterium nucleatum infection without internal or external jugular venous thrombophlebitis. 62
35516791 2022
41
Cervicofacial Cellulitis due to Staphylococcus aureus with Jugular Vein Thrombosis and Multiple Septic Pulmonary Embolism: A Lemierre-Like Syndrome. 62
36062238 2022
42
Lemierre Syndrome Due to Dialister pneumosintes: A Case Report. 62
35668853 2022
43
The Role of Extracorporeal Blood Purification in the Treatment of a Patient with Lemierre's Syndrome. 62
35669315 2022
44
Lemierre's syndrome with isolated external jugular vein thrombosis caused by Streptococcus intermedius. 62
35402160 2022
45
Lemierre syndrome complicating otitis media caused by Streptococcus pneumoniae. 62
35070714 2022
46
Lemierre's syndrome in a child. 62
35310801 2022
47
A Brief Shared Decision-Making Intervention for Acute Respiratory Infections on Antibiotic Dispensing Rates in Primary Care: A Cluster Randomized Trial. 62
35074766 2022
48
Atypical Lemierre's Syndrome. A Case Report and Review of Literature. 62
35711878 2022
49
Abdominal variant Lemierre's syndrome. 62
35129386 2022
50
Severe thrombocytopenia and jaundice associated with Lemierre's syndrome: A case report. 62
35003423 2022

Variations for Lemierre's Syndrome

Expression for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.

Pathways for Lemierre's Syndrome

GO Terms for Lemierre's Syndrome

Cellular components related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.43 SERPINC1 PLG F2
2 collagen-containing extracellular matrix GO:0062023 9.23 SERPINC1 PLG F3 F2

Biological processes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 9.62 PLG F2
2 negative regulation of fibrinolysis GO:0051918 9.56 PLG F2
3 blood coagulation GO:0007596 9.56 SERPINC1 PLG F3 F2
4 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2
5 hemostasis GO:0007599 8.92 SERPINC1 PLG F3 F2

Molecular functions related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.63 SERPINC1 F3 ACR
2 serine-type peptidase activity GO:0008236 9.35 PLG F2 ACR
3 serine-type endopeptidase activity GO:0004252 9.23 PLG F3 F2 ACR

Sources for Lemierre's Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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