MCID: LMR001
MIFTS: 42

Lemierre's Syndrome

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Oral diseases, Rare diseases

Aliases & Classifications for Lemierre's Syndrome

MalaCards integrated aliases for Lemierre's Syndrome:

Name: Lemierre's Syndrome 12 74 52 15
Lemierre Syndrome 12 52 58 71
Postanginal Sepsis Secondary to Orophyngeal Infection 52 58
Septic Phlebitis of the Internal Jugular Vein 52 58
Lemierre Postanginal Sepsis 52 58
Fusobacterium Infections 43 71
Necrobacillosis 52 71
Oropharyngeal Infection Leading to Secondary Septic Thrombophlebitis of the Internal Jugular Vein 52
Human Necrobacillosis 12
Postanginal Sepsis 12
Acute Sore Throat 12

Characteristics:

Orphanet epidemiological data:

58
lemierre syndrome
Age of onset: Adolescent; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11337
ICD9CM 34 040.3
MeSH 43 D005674
SNOMED-CT 67 52542005
MESH via Orphanet 44 D057831
ICD10 via Orphanet 33 I80.8
UMLS via Orphanet 72 C0343525
Orphanet 58 ORPHA137839
UMLS 71 C0016879 C0027537 C0343525

Summaries for Lemierre's Syndrome

NIH Rare Diseases : 52 Lemierre syndrome is a rare and potentially life-threatening complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection . The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum , although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to life-threatening complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs , and/or septic shock (in about 7% of cases). Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies. Because most throat infections in young, healthy people do not cause severe health problems, diagnosis and treatment may be delayed. The main treatment involves intravenous antibiotic therapy over several weeks, but surgery may be necessary when there is abscess formation , respiratory distress, or severe clotting in the chest or brain. The long-term outlook and chance of survival in people with Lemierre syndrome varies depending on how much the syndrome progresses, but even with appropriate treatment, it is fatal in some cases.

MalaCards based summary : Lemierre's Syndrome, also known as lemierre syndrome, is related to pharyngitis and pleural empyema. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Benzydamine and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include tonsil, liver and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia : 74 Lemierre's syndrome refers to infectious thrombophlebitis of the internal jugular vein. It most often... more...

Related Diseases for Lemierre's Syndrome

Diseases related to Lemierre's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 363)
# Related Disease Score Top Affiliating Genes
1 pharyngitis 30.9 SUCLG2 CRP
2 pleural empyema 30.8 F2 CRP
3 toxic shock syndrome 30.6 SERPINC1 F3 CRP
4 thrombophlebitis 30.5 SERPINC1 MTHFR F3 F2 CRP
5 mediastinitis 30.3 F3 F2 CRP
6 pneumonia 30.3 F3 F2 CRP
7 thrombosis 30.2 SERPINC1 MTHFR F3 F2
8 carotid artery thrombosis 30.2 SERPINC1 F3
9 epidural abscess 30.1 F3 F2 CRP
10 hemopericardium 30.1 F3 F2
11 thrombophilia due to thrombin defect 30.1 SERPINC1 MTHFR F3 F2
12 hemarthrosis 30.0 F3 F2
13 mastoiditis 30.0 SERPINC1 MTHFR F2 CRP
14 cardiac tamponade 30.0 F3 F2 CRP
15 mycoplasma pneumoniae pneumonia 30.0 F3 CRP
16 bilirubin metabolic disorder 30.0 F3 F2 CRP
17 factor xii deficiency 29.9 SERPINC1 F3
18 cavernous sinus thrombosis 29.8 SERPINC1 F3 F2 CRP
19 pulmonary embolism 29.8 SERPINC1 MTHFR F3 F2 CRP
20 tricuspid valve insufficiency 29.8 F3 F2 CRP
21 pericardial effusion 29.7 F3 F2 CRP
22 exanthem 29.7 F3 F2 CRP
23 leptospirosis 29.7 F2 CRP
24 disseminated intravascular coagulation 29.7 SERPINC1 F3 F2 CRP
25 endocarditis 29.7 SERPINC1 F2 CRP
26 thrombophilia 29.6 SERPINC1 MTHFR F3 F2
27 fournier gangrene 29.6 SERPINC1 F3 F2
28 cerebral palsy 29.6 SERPINC1 MTHFR F2
29 purpura fulminans 29.6 SERPINC1 F3 F2
30 respiratory failure 29.6 NDUFA5 F3 F2 CRP
31 acute myocardial infarction 29.5 SERPINC1 F3 CRP
32 intracranial thrombosis 29.5 SERPINC1 MTHFR F3 F2
33 portal vein thrombosis 29.3 SERPINC1 MTHFR F2 CRP
34 lateral sinus thrombosis 29.3 SERPINC1 MTHFR F3 F2
35 thrombophilia due to activated protein c resistance 29.3 SERPINC1 MTHFR F3 F2
36 budd-chiari syndrome 29.2 SERPINC1 MTHFR F3 F2
37 purpura 29.2 SERPINC1 F3 F2 CRP
38 pulmonary hypertension 29.1 SERPINC1 F3 F2 CRP
39 antiphospholipid syndrome 28.8 SERPINC1 MTHFR F3 F2 CRP
40 patent foramen ovale 28.8 SERPINC1 MTHFR F3 F2 CRP
41 thrombocytopenia 28.8 SERPINC1 MTHFR F3 F2 CRP
42 myocardial infarction 28.7 SERPINC1 MTHFR F3 F2 CRP
43 inflammatory bowel disease 28.7 SERPINC1 MTHFR F3 F2 CRP
44 tonsillitis 10.6
45 septic arthritis 10.4
46 osteomyelitis 10.4
47 pregnancy loss, recurrent 1 10.3 MTHFR HOTAIR
48 otitis media 10.3
49 acute kidney failure 10.3
50 dysphagia 10.3

Graphical network of the top 20 diseases related to Lemierre's Syndrome:



Diseases related to Lemierre's Syndrome

Symptoms & Phenotypes for Lemierre's Syndrome

GenomeRNAi Phenotypes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.81 SUCLG2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.81 ACR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.81 MTHFR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.81 ACR
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.81 MTHFR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.81 F2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.81 MTHFR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.81 F2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.81 CRP
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.81 ACR
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.81 MTHFR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.81 CRP
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.81 MTHFR
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.81 MTHFR CRP
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.81 MTHFR
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.81 ACR
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.81 MTHFR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.81 CRP
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.81 MTHFR
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.81 MTHFR

Drugs & Therapeutics for Lemierre's Syndrome

Drugs for Lemierre's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzydamine Approved Phase 3 100-46-9, 642-72-8 7504
2
Ibuprofen Approved Phase 3 15687-27-1 3672
3
Sage Approved Phase 3
4
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
5
Echinacea Approved, Experimental Phase 3
6
Chlorhexidine Approved, Vet_approved Phase 3 55-56-1 9552079 2713
7 Pharmaceutical Solutions Phase 3
8 Muramidase Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Analgesics Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Antirheumatic Agents Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Sodium Channel Blockers Phase 3
16 Anti-Infective Agents Phase 3
17 Anesthetics Phase 3
18 Chlorhexidine gluconate Phase 3
19 Anti-Arrhythmia Agents Phase 3
20 Anti-Infective Agents, Local Phase 3
21 Diuretics, Potassium Sparing Phase 3
22 Anesthetics, Local Phase 3
23 Disinfectants Phase 3
24
Flurbiprofen Approved, Investigational Phase 2 5104-49-4 3394
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
26 retinol Phase 2
27 Retinol palmitate Phase 2
28
Thyme Approved
29 Propolis
30 Bee Products

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Single-blind, Randomized, Placebo-controlled Comparative Study on Efficacy and Safety of the Lysobact Complete Spray®, Tantum Verde® Spray and Pharyngal® Oromucosal Spray in the Treatment of Acute Sore Throat in Common Cold Unknown status NCT03282045 Phase 3 Lysobact Complete Sprey;Tantum Verde® Spray;Pharyngal® Oromucosal Spray;Placebo
2 Study of Efficacy and Safety of V0498 Versus Placebo in Acute Sore Throat Pain. Completed NCT01785862 Phase 3 Ibuprofen 25 mg;Placebo
3 Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats Completed NCT00707902 Phase 3 chlorhexidine/lidocaine;echinacea/sage
4 Analgesic Profile of 3 New Ibuprofen Lozenges (V0498TA01A 15 mg, 25 mg, 35 mg) After Single Administration in Acute Sore Throat Pain Completed NCT01535079 Phase 2 Placebo;Ibuprofen 35 mg;Ibuprofen 25 mg;Ibuprofen 15 mg;Strefen
5 Efficacy of Natural Seawater Based Throat Spray in Acute Sore Throat Relief: a Prospective, Randomized, Double-blind, Placebo-controlled, Multicentre Clinical Study Unknown status NCT03369132
6 Ear Acupuncture for Acute Sore Throat. A Randomized Controlled Trial. Completed NCT01302769
7 Ear Acupuncture for Acute Sore Throat in Patients Unable to Take Non-steroidal Anti-inflammatory Agents (NSAIDs) Completed NCT01301482

Search NIH Clinical Center for Lemierre's Syndrome

Cochrane evidence based reviews: fusobacterium infections

Genetic Tests for Lemierre's Syndrome

Anatomical Context for Lemierre's Syndrome

MalaCards organs/tissues related to Lemierre's Syndrome:

40
Tonsil, Liver, Lung, Brain, Spleen, Heart, Kidney

Publications for Lemierre's Syndrome

Articles related to Lemierre's Syndrome:

(show top 50) (show all 752)
# Title Authors PMID Year
1
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. 52 61
30071559 2019
2
[Lemierre's syndrome: Diagnosis, exploration, treatment]. 52 61
29269194 2018
3
The long shadow of lemierre's syndrome. 52 61
28646962 2017
4
Fusobacterial head and neck infections in children. 61 52
25980688 2015
5
Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review. 61 52
23845534 2013
6
Infections of the Neck. 52
30454783 2019
7
Lemierre's syndrome: A rare cause of septic emboli in a young adult. 61
32382372 2020
8
A 4-year-old boy with Lemierre's syndrome caused by methicillin-sensitive Staphylococcus aureus. 61
32507402 2020
9
Unilateral proptosis in Lemierre's syndrome variant. 61
32546572 2020
10
[Cervicofacial cellulitis complicated by internal jugular vein thrombosis]. 61
32505376 2020
11
Cavernous sinus thrombosis caused by Streptococcus constellatus-associated Lemierre syndrome presenting as an isolated abducens nerve palsy. 61
32123771 2020
12
Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases. 61
32445216 2020
13
Lemierre Syndrome: An emerging not forgotten disease. 61
32439302 2020
14
Lemierre syndrome - treat with antibiotics, anticoagulants or both? 61
32419246 2020
15
[Gynecological Lemierre's syndrome: A case report and literature review]. 61
32371121 2020
16
Lemierre syndrome, a rare complication of otitis media. 61
32402432 2020
17
Lemierre's syndrome: A forgotten and re-emerging infection. 61
32303484 2020
18
A Rare Case of Lemierre's Syndrome Caused by Streptococcus Intermedius, Presenting as an Epidural Abscess. 61
32455086 2020
19
Lemierre syndrome complicating deep neck infection and descending necrotizing mediastinits caused by odontogenic infections. 61
31708482 2020
20
Fusobacterium bloodstream infections: A literature review and hospital-based case series. 61
32004686 2020
21
Anaerobic Necrotizing Pneumonia: Another Potential Life-threatening Complication of Vaping? 61
32132153 2020
22
Lemierre's syndrome complicating influenza A virus infection. 61
32161697 2020
23
Lemierre's syndrome caused by Streptococcus pyogenes in an elderly woman. 61
32055760 2020
24
Fusobacterium necrophorum Septicemia Leading to Lemierre's Syndrome in an Immunocompetent Individual: A Case Report. 61
32257727 2020
25
Bacteremia and sepsis by Arcanobacterium haemolyticum in a young immunocompetent patient. 61
32201068 2020
26
A unique case of Lemierre's syndrome status post blunt cervical trauma. 61
32228176 2020
27
A Lemierre-like syndrome caused by Staphylococcus aureus: an emerging disease. 61
31749395 2020
28
Lemierre's syndrome in an acute myocardial infarction patient. 61
31706822 2020
29
Lemierre's syndrome in adulthood, a case report and systematic review. 61
32116143 2020
30
An Unusual Case of Modified Lemierre's Syndrome Caused by Staphylococcus aureus Cellulitis. 61
32008035 2020
31
Lemierre's syndrome with stroke and stenosis of the internal carotid artery suggesting focal vasculitis. 61
31869591 2020
32
The Forgotten Disease: A Case of Lemierre's Syndrome with Distal Extremity Involvement. 61
32257468 2020
33
Fusobacterium necrophorum subsp. necrophorum Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre's Syndrome. 61
31993242 2020
34
Lemierre's syndrome: A re-emerging infection. 61
31768313 2020
35
Case of internal jugular vein thrombosis and fever: Lemierre's syndrome or Trousseau's syndrome? 61
32110528 2020
36
Deep neck space infection and Lemierre's syndrome caused by Streptococcus anginosus: A case report. 61
32226760 2020
37
Diagnosis and Management of Lemierre's Syndrome Presented with Multifocal Pneumonia and Cerebral Venous Sinus Thrombosis. 61
32231820 2020
38
Lemierre syndrome caused by Klebsiella pneumoniae complicated by epidural abscess - Case report. 61
32226757 2020
39
A Case of Lemierre Syndrome Complicated with Empyema. 61
31327844 2019
40
Lemierre syndrome leading to ankylosis of the temporomandibular joint. 61
31708222 2019
41
Bilateral abducens nerve palsy due to septic thrombophlebitis. 61
31737802 2019
42
Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome: an 8-year Swedish nationwide retrospective study. 61
31843654 2019
43
Lemierre's syndrome: a possible cause of neck pain. 61
31535288 2019
44
[A sepsis that you don't expect… Lemierre's syndrome. Description of a clinical case.] 61
31808441 2019
45
Lemierre's Syndrome: An Atypical Presentation. 61
31201970 2019
46
Atypical presentation of Lemierre's syndrome: case report and literature review. 61
31638919 2019
47
[Lemierre syndrome - a frequently overlooked infectious disease]. 61
31594022 2019
48
[Lemierre syndrome as a result of a sinusitis sphenoidalis]. 61
31323690 2019
49
Lemierre syndrome due to Klebsiella pneumoniae. 61
31625315 2019
50
An unusual cause of Lemierre Syndrome. 61
30772450 2019

Variations for Lemierre's Syndrome

Expression for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.

Pathways for Lemierre's Syndrome

Pathways related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.66 MTHFR F2 CRP
2
Show member pathways
11.33 SERPINC1 F3 F2
3 10.96 SERPINC1 F3 F2

GO Terms for Lemierre's Syndrome

Biological processes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 SERPINC1 F3 F2
2 acute-phase response GO:0006953 9.26 F2 CRP
3 regulation of blood coagulation GO:0030193 8.96 SERPINC1 F2
4 hemostasis GO:0007599 8.8 SERPINC1 F3 F2

Molecular functions related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F3 F2 ACR
2 protease binding GO:0002020 8.8 SERPINC1 F3 ACR

Sources for Lemierre's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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