MCID: LMR001
MIFTS: 40

Lemierre's Syndrome

Categories: Blood diseases, Cardiovascular diseases, Infectious diseases, Oral diseases, Rare diseases

Aliases & Classifications for Lemierre's Syndrome

MalaCards integrated aliases for Lemierre's Syndrome:

Name: Lemierre's Syndrome 12 74 52 15
Lemierre Syndrome 12 52 58 71
Postanginal Sepsis Secondary to Orophyngeal Infection 52 58
Septic Phlebitis of the Internal Jugular Vein 52 58
Lemierre Postanginal Sepsis 52 58
Fusobacterium Infections 43 71
Necrobacillosis 52 71
Oropharyngeal Infection Leading to Secondary Septic Thrombophlebitis of the Internal Jugular Vein 52
Human Necrobacillosis 12
Postanginal Sepsis 12
Acute Sore Throat 12

Characteristics:

Orphanet epidemiological data:

58
lemierre syndrome
Age of onset: Adolescent; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11337
ICD9CM 34 040.3
MeSH 43 D005674
SNOMED-CT 67 52542005
MESH via Orphanet 44 D057831
ICD10 via Orphanet 33 I80.8
UMLS via Orphanet 72 C0343525
Orphanet 58 ORPHA137839
UMLS 71 C0016879 C0027537 C0343525

Summaries for Lemierre's Syndrome

NIH Rare Diseases : 52 Lemierre syndrome is a rare and potentially life-threatening complication of bacterial infections that usually affects previously-healthy adolescents and young adults. It most commonly develops in association with a bacterial throat infection, but it may develop in association with an infection involving the ears, salivary glands (parotitis), sinuses, or teeth; or in association with an Epstein-Barr infection . The bacteria typically responsible for infection in Lemierre syndrome is Fusobacterium necrophorum , although a variety of bacteria can be responsible. In people with Lemierre syndrome, the initial infection spreads into tissues and deep spaces within the neck, leading to the formation of an infected blot clot (septic thrombophlebitis), sometimes made up of pus, in the internal jugular vein (the blood vessel that carries blood away from the brain, face, and neck). In addition to worsening symptoms of the initial infection, symptoms at this stage of the disease typically include persistent fever and chills (rigors), as well as pain, tenderness and swelling of the throat and neck. The infected clot then circulates in the blood (septicemia), resulting in the infection also spreading to the lungs (most commonly), skeletal system, and/or other parts of the body such as the spleen, liver, kidney, heart, or brain. This can lead to life-threatening complications such as respiratory distress syndrome due to pulmonary emboli (blood clots in the lung), damage to other affected organs , and/or septic shock (in about 7% of cases). Lemierre syndrome may be diagnosed based on signs and symptoms, various blood tests, and imaging studies. Because most throat infections in young, healthy people do not cause severe health problems, diagnosis and treatment may be delayed. The main treatment involves intravenous antibiotic therapy over several weeks, but surgery may be necessary when there is abscess formation , respiratory distress, or severe clotting in the chest or brain. The long-term outlook and chance of survival in people with Lemierre syndrome varies depending on how much the syndrome progresses, but even with appropriate treatment, it is fatal in some cases.

MalaCards based summary : Lemierre's Syndrome, also known as lemierre syndrome, is related to pharyngitis and cavernous sinus thrombosis. An important gene associated with Lemierre's Syndrome is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways is Folate Metabolism. The drugs Benzydamine and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include tonsil, liver and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

Wikipedia : 74 Lemierre's syndrome refers to infectious thrombophlebitis of the internal jugular vein. It most often... more...

Related Diseases for Lemierre's Syndrome

Diseases related to Lemierre's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 329)
# Related Disease Score Top Affiliating Genes
1 pharyngitis 31.2 SUCLG2 CRP
2 cavernous sinus thrombosis 30.8 F2 CRP
3 thrombophlebitis 30.7 MTHFR F3 F2 CRP
4 mediastinitis 30.6 F2 CRP
5 mastoiditis 30.5 MTHFR F2 CRP
6 thrombosis 30.5 MTHFR F3 F2
7 thrombophilia due to thrombin defect 30.3 MTHFR F3 F2
8 necrotizing fasciitis 30.2 F3 CRP
9 epidural abscess 30.2 F3 CRP
10 lateral sinus thrombosis 30.2 MTHFR F2
11 portal vein thrombosis 30.0 MTHFR F2 CRP
12 pulmonary embolism 30.0 MTHFR F3 F2 CRP
13 pneumonia 30.0 F3 F2 CRP
14 epiglottitis 30.0 SUCLG2 CRP APELA
15 thrombophilia 29.9 MTHFR F3 F2
16 disseminated intravascular coagulation 29.9 F3 F2 CRP
17 fournier gangrene 29.9 F3 F2
18 leptospirosis 29.8 F2 CRP
19 hemopericardium 29.8 F3 F2
20 hemarthrosis 29.8 F3 F2
21 intracranial thrombosis 29.8 MTHFR F3 F2
22 mycoplasma pneumoniae pneumonia 29.7 F3 CRP
23 cardiac tamponade 29.7 F3 F2 CRP
24 purpura fulminans 29.7 F3 F2
25 bilirubin metabolic disorder 29.7 F3 F2 CRP
26 thrombophilia due to activated protein c resistance 29.5 MTHFR F3 F2
27 budd-chiari syndrome 29.5 MTHFR F3 F2
28 tricuspid valve insufficiency 29.5 F3 F2 CRP
29 pericardial effusion 29.5 F3 F2 CRP
30 exanthem 29.5 F3 F2 CRP
31 purpura 29.4 F3 F2 CRP
32 heart valve disease 29.4 F3 F2 CRP
33 respiratory failure 29.3 NDUFA5 F3 F2 CRP
34 antiphospholipid syndrome 29.1 MTHFR F3 F2 CRP
35 patent foramen ovale 29.1 MTHFR F3 F2 CRP
36 tonsillitis 10.6
37 toxic shock syndrome 10.5
38 septic arthritis 10.4
39 osteomyelitis 10.4
40 pregnancy loss, recurrent 1 10.4 MTHFR HOTAIR
41 otitis media 10.3
42 acute kidney failure 10.3
43 pleural empyema 10.3
44 cerebral atherosclerosis 10.3 MTHFR CRP
45 riboflavin deficiency 10.3 MTHFR CRP
46 dysphagia 10.3
47 vitamin metabolic disorder 10.3 MTHFR CRP
48 retinal artery occlusion 10.3 MTHFR F2
49 arteritic anterior ischemic optic neuropathy 10.3 MTHFR F2
50 prothrombin-related thrombophilia 10.3 MTHFR F2

Graphical network of the top 20 diseases related to Lemierre's Syndrome:



Diseases related to Lemierre's Syndrome

Symptoms & Phenotypes for Lemierre's Syndrome

GenomeRNAi Phenotypes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

26 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.89 ACR
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.89 MTHFR
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.89 ACR
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.89 CRP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.89 MTHFR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-155 9.89 ACR
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.89 ACR
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.89 ACR
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.89 MTHFR
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.89 ACR CRP MTHFR
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.89 ACR
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.89 MTHFR
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.89 CRP
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.89 MTHFR
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.89 MTHFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 SUCLG2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.64 F2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.64 F2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.64 SUCLG2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.64 F2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.64 F2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.64 SUCLG2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.64 F2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.64 MTHFR
25 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.64 F2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.64 MTHFR
27 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.64 MTHFR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.64 F2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.64 MTHFR
30 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.64 SUCLG2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.64 MTHFR
32 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 MTHFR
33 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.64 MTHFR
34 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.64 F2 MTHFR SUCLG2

Drugs & Therapeutics for Lemierre's Syndrome

Drugs for Lemierre's Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzydamine Approved Phase 3 100-46-9, 642-72-8 7504
2
Ibuprofen Approved Phase 3 15687-27-1 3672
3
Sage Approved Phase 3
4
Echinacea Approved, Experimental Phase 3
5
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
6 Muramidase Phase 3
7 Pharmaceutical Solutions Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Analgesics Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Antirheumatic Agents Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Anti-Arrhythmia Agents Phase 3
15 Anesthetics, Local Phase 3
16 Chlorhexidine gluconate Phase 3
17 Sodium Channel Blockers Phase 3
18 Anesthetics Phase 3
19 Dermatologic Agents Phase 3
20 Diuretics, Potassium Sparing Phase 3
21 Disinfectants Phase 3
22 Central Nervous System Depressants Phase 3
23 Anti-Infective Agents Phase 3
24 Anti-Infective Agents, Local Phase 3
25
Flurbiprofen Approved, Investigational Phase 2 5104-49-4 3394
26
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
27 Retinol palmitate Phase 2
28 retinol Phase 2
29
Thyme Approved
30 Propolis
31 Bee Products

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter, Single-blind, Randomized, Placebo-controlled Comparative Study on Efficacy and Safety of the Lysobact Complete Spray®, Tantum Verde® Spray and Pharyngal® Oromucosal Spray in the Treatment of Acute Sore Throat in Common Cold Unknown status NCT03282045 Phase 3 Lysobact Complete Sprey;Tantum Verde® Spray;Pharyngal® Oromucosal Spray;Placebo
2 Study of Efficacy and Safety of V0498 Versus Placebo in Acute Sore Throat Pain. Completed NCT01785862 Phase 3 Ibuprofen 25 mg;Placebo
3 Multicentric Randomized Double Blind Double Dummy Placebo Controlled Clinical Trial for Assessment of Safety and Efficacy of a Echinacea/Sage Spray in Comparison to a Chlorhexidine/Lidocaine Spray in the Treatment of Acute Sore Throats Completed NCT00707902 Phase 3 chlorhexidine/lidocaine;echinacea/sage
4 Analgesic Profile of 3 New Ibuprofen Lozenges (V0498TA01A 15 mg, 25 mg, 35 mg) After Single Administration in Acute Sore Throat Pain Completed NCT01535079 Phase 2 Placebo;Ibuprofen 35 mg;Ibuprofen 25 mg;Ibuprofen 15 mg;Strefen
5 Efficacy of Natural Seawater Based Throat Spray in Acute Sore Throat Relief: a Prospective, Randomized, Double-blind, Placebo-controlled, Multicentre Clinical Study Unknown status NCT03369132
6 Ear Acupuncture for Acute Sore Throat. A Randomized Controlled Trial. Completed NCT01302769
7 Ear Acupuncture for Acute Sore Throat in Patients Unable to Take Non-steroidal Anti-inflammatory Agents (NSAIDs) Completed NCT01301482

Search NIH Clinical Center for Lemierre's Syndrome

Cochrane evidence based reviews: fusobacterium infections

Genetic Tests for Lemierre's Syndrome

Anatomical Context for Lemierre's Syndrome

MalaCards organs/tissues related to Lemierre's Syndrome:

40
Tonsil, Liver, Lung, Brain, Spleen, Heart, Kidney

Publications for Lemierre's Syndrome

Articles related to Lemierre's Syndrome:

(show top 50) (show all 724)
# Title Authors PMID Year
1
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. 61 52
30071559 2019
2
[Lemierre's syndrome: Diagnosis, exploration, treatment]. 52 61
29269194 2018
3
The long shadow of lemierre's syndrome. 52 61
28646962 2017
4
Fusobacterial head and neck infections in children. 52 61
25980688 2015
5
Lemierre syndrome associated with 12th cranial nerve palsy--a case report and review. 61 52
23845534 2013
6
Infections of the Neck. 52
30454783 2019
7
Lemierre's syndrome: A re-emerging infection. 61
31768313 2020
8
Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome - An eight-year Swedish nationwide retrospective study. 61
31843654 2019
9
Lemierre syndrome leading to ankylosis of the temporomandibular joint. 61
31708222 2019
10
A Case of Lemierre Syndrome Complicated with Empyema. 61
31327844 2019
11
Bilateral abducens nerve palsy due to septic thrombophlebitis. 61
31737802 2019
12
Lemierre's syndrome: a possible cause of neck pain. 61
31535288 2019
13
[A sepsis that you don't expect… Lemierre's syndrome. Description of a clinical case.] 61
31808441 2019
14
A Lemierre-like syndrome caused by Staphylococcus aureus: an emerging disease. 61
31749395 2019
15
Lemierre's syndrome in an acute myocardial infarction patient. 61
31706822 2019
16
Lemierre's Syndrome: An Atypical Presentation. 61
31201970 2019
17
Atypical presentation of Lemierre's syndrome: case report and literature review. 61
31638919 2019
18
[Lemierre syndrome - a frequently overlooked infectious disease]. 61
31594022 2019
19
Lemierre syndrome due to Klebsiella pneumoniae. 61
31625315 2019
20
[Lemierre syndrome as a result of a sinusitis sphenoidalis]. 61
31323690 2019
21
Lemierre syndrome complicating deep neck infection and descending necrotizing mediastinits caused by odontogenic infections. 61
31708482 2019
22
An unusual cause of Lemierre Syndrome. 61
30772450 2019
23
A prostatic Lemierre syndrome. 61
31075506 2019
24
Thoracic pain associated with an odontogenic infection: An unusual Lemierre's syndrome. 61
31192470 2019
25
A case of Lemierre-like Syndrome: internal jugular vein thrombosis secondary to Staphylococcus aureus sternoclavicular joint septic arthritis. 61
31293789 2019
26
Methicillin-Resistant Staphylococcus aureus Septic Internal Jugular Thrombophlebitis: Updates in the Etiology and Treatment of Lemierre's Syndrome. 61
31229258 2019
27
Mastoiditis with concomitant Lemierre's syndrome. 61
30786966 2019
28
Lemierre's syndrome: a case study with a short review of literature. 61
29783881 2019
29
Lemierre's syndrome: A forgotten complication of acute pharyngitis. 61
30291034 2019
30
Fusobacterium necrophorum septic pelvic thrombophlebitis after intrauterine device insertion. 61
30648745 2019
31
Lemierre's syndrome: a disguised threat. 61
31015242 2019
32
Lemierre's Syndrome. 61
30893539 2019
33
Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study. 61
30900550 2019
34
An Unusual Presentation of Nasopharyngeal Carcinoma as Lemierre Syndrome. 61
30814483 2019
35
Antibiotic and Anticoagulation Therapy in Lemierre's Syndrome: Case Report and Review. 61
30773133 2019
36
Lemierre's syndrome: One rare disease-Two case studies. 61
30484880 2019
37
Rare and life-threatening complication after an attempted lower third molar extraction: Lemierre syndrome. 61
30372118 2019
38
Fatal Fusobacterium necrophorum infection with gynecological Lemierre's syndrome. 61
30309662 2019
39
Lemierre's Syndrome Due to Methicillin-Resistant Staphylococcus aureus. 61
31795752 2019
40
A Case of Fusobacterium necrophorum without Lemierre's Syndrome Mimicking Acute Leptospirosis. 61
31662923 2019
41
Lemierre's Syndrome Caused by Streptococcus anginosus Presenting as Postseptal Cellulitis in a Pediatric Patient. 61
31315119 2019
42
Surgical Management of Descending Necrotizing Mediastinitis Complicated by Purulent Pericarditis and Lemierre's Syndrome. 61
30760372 2019
43
Complete Genome Sequences of Two Isolates of Fusobacterium necrophorum subsp. funduliforme, Obtained from Blood from Patients with Lemierre's Syndrome. 61
30701252 2019
44
Severe case of pneumonia with pleural effusion in an immunocompromised woman due to Fusobacterium necrophorum. 61
30709834 2019
45
Septic emboli of the lung due to Fusobacterium necrophorum, a case of Lemierre's syndrome. 61
31211045 2019
46
Fusobacterium necrophorum sepsis after tonsillitis/pharyngitis. 61
30700448 2019
47
Use of Direct Hemoperfusion with Polymyxin B-Immobilized Fiber for the Treatment of Septic Shock Complicated with Lemierre Syndrome Caused by Fusobacterium necrophorum. 61
31467732 2019
48
A case of Lemierre syndrome combined with a suspected systemic lupus erythematosus flare. 61
31489196 2019
49
Lemierre Syndrome. A Forgotten Disease. Case Report and Review of Literature. 61
31819670 2019
50
Improved Detection of Culprit Pathogens by Bacterial DNA Sequencing Affects Antibiotic Management Decisions in Severe Pneumonia. 61
30473582 2018

Variations for Lemierre's Syndrome

Expression for Lemierre's Syndrome

Search GEO for disease gene expression data for Lemierre's Syndrome.

Pathways for Lemierre's Syndrome

Pathways related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 MTHFR F2 CRP

GO Terms for Lemierre's Syndrome

Biological processes related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 F2 CRP

Molecular functions related to Lemierre's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 F3 F2 ACR

Sources for Lemierre's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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