MCID: LNS003
MIFTS: 34

Lens Disease

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Lens Disease

Summaries for Lens Disease

Disease Ontology : 12 An eye disease that affects the lens of the eye, which is the transparent disc that focuses light to the photosensors in the back of the eye.

MalaCards based summary : Lens Disease, also known as lens diseases, is related to cataract and rare lens disease, and has symptoms including eye manifestations An important gene associated with Lens Disease is CRYAA (Crystallin Alpha A). Affiliated tissues include eye, retina and bone, and related phenotype is vision/eye.

Wikipedia : 74 The lens is a transparent, biconvex structure in the eye that, along with the cornea, helps to refract... more...

Related Diseases for Lens Disease

Diseases in the Lens Disease family:

Rare Lens Disease

Diseases related to Lens Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 cataract 32.2 WRN VEGFA TRNT1 PAX6 OCRL MIR204
2 rare lens disease 12.2
3 isolated ectopia lentis 10.9
4 retinal perforation 10.8 VEGFA CRYGS CRYAA
5 eye accommodation disease 10.8 LAMA3 CRYGS CRYAA
6 blood group, globoside system 10.8 VEGFA LAMA3 CRYAA
7 retinal microaneurysm 10.8 VEGFA INS AKR1B1
8 intravascular papillary endothelial hyperplasia 10.8 VEGFA SERPINA3
9 severe nonproliferative diabetic retinopathy 10.8 VEGFA INS AKR1B1
10 endophthalmitis 10.7 VEGFA LAMA3 CRYAA
11 vitreous disease 10.7 VEGFA PAX6 CRYAA
12 xeroderma pigmentosum, complementation group d 10.7 H2AC18 ERCC6 CRYAA
13 background diabetic retinopathy 10.7 VEGFA INS AKR1B1
14 galactokinase deficiency 10.7 CRYGS CRYAA AKR1B1
15 axenfeld-rieger syndrome, type 1 10.7 PAX6 FOXE3 CRYAA
16 sclerocornea 10.7 PAX6 FOXE3 CRYAA
17 juvenile glaucoma 10.7 PAX6 FOXE3 CRYAA
18 early-onset nuclear cataract 10.7 GJA3 CRYBB2 CRYAA
19 spinal and bulbar muscular atrophy, x-linked 1 10.7 ERCC6 DMPK CRYAA
20 nuclear senile cataract 10.7 LAMA3 CRYGS
21 cataract 4, multiple types 10.7 TRNT1 SERPINA3 CCT3
22 macular retinal edema 10.7 VEGFA INS AKR1B1
23 myotonic disease 10.7 ERCC6 DMPK CCT3
24 early-onset sutural cataract 10.7 CRYGS CRYBB2
25 telangiectasis 10.7 VEGFA H2AC18 ERCC6
26 congenital nervous system abnormality 10.7 PAX6 H2AC18 ERCC6 CRYAA
27 retinal vascular occlusion 10.7 VEGFA CRYAA CFHR2
28 fanconi anemia, complementation group j 10.7 WRN H2AC18 ERCC6
29 myotonic dystrophy 1 10.7 ERCC6 DMPK CCT3
30 retinal artery occlusion 10.7 VEGFA CRYAA CFHR2
31 ocular motility disease 10.7 SERPINA3 PAX6 CRYAA
32 cerebral degeneration 10.7 SERPINA3 H2AC18 ERCC6 CRYAA
33 diabetic polyneuropathy 10.7 VEGFA INS AKR1B1
34 physical disorder 10.7 PAX6 H2AC18 ERCC6 CRYAA
35 hair disease 10.7 VEGFA INS H2AC18 ERCC6
36 carbohydrate metabolic disorder 10.7 INS H2AC18 CRYAA
37 intestinal benign neoplasm 10.7 VEGFA SERPINA3 H2AC18 ERCC6
38 oropharynx cancer 10.7 VEGFA SERPINA3 H2AC18
39 keratitis, hereditary 10.7 VEGFA PAX6 CRYAA
40 presbyopia 10.7 LAMA3 FOXE3 CRYGS CRYAA
41 senile cataract 10.7 WRN LAMA3 CRYGS CRYAA
42 chromosomal disease 10.7 SERPINA3 H2AC18 ERCC6 CRYAA
43 cardiovascular organ benign neoplasm 10.7 VEGFA SERPINA3 H2AC18
44 malignant ovarian surface epithelial-stromal neoplasm 10.7 VEGFA SERPINA3 H2AC18 ERCC6
45 optic nerve disease 10.7 VEGFA SERPINA3 ERCC6 CRYAA
46 ovary epithelial cancer 10.7 VEGFA SERPINA3 H2AC18 ERCC6
47 cell type benign neoplasm 10.7 VEGFA SERPINA3 H2AC18 ERCC6
48 peripheral vascular disease 10.7 VEGFA INS H2AC18 ERCC6
49 retroperitoneal hemangiopericytoma 10.7 VEGFA INS
50 iris disease 10.7 SERPINA3 PAX6 FOXE3 CRYAA

Graphical network of the top 20 diseases related to Lens Disease:



Diseases related to Lens Disease

Symptoms & Phenotypes for Lens Disease

UMLS symptoms related to Lens Disease:


eye manifestations

MGI Mouse Phenotypes related to Lens Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.32 AKR1B1 CRYBB2 CRYGS ERCC6 GJA3 INS

Drugs & Therapeutics for Lens Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Spherical Aberration and Contrast Sensitivity in Eyes Implanted With Aspheric and Spherical Intraocular Lenses: Clinical Comparative Study Completed NCT00576485 Phase 4
2 Visual Performance of Pseudophakic Patient With Different Intraocular Lenses Unknown status NCT01763411
3 Study of the Incidence of Retinal Detachment After Lens Surgery in the Nearsighted Completed NCT04072939
4 Refinement of the Magnetic Resonance Imaging Technique for the Study of the Normal Eye, Particularly the Lens and Cataract Completed NCT00005911
5 The Possible Association Between Pseudoexfoliation Syndrome and Diabetes Mellitus in an Egyptian Population Not yet recruiting NCT03741153
6 Development of a New Patient Reported Outcome (PRO) Measure for Refractive Surgery Patients as Part of the National Dataset in Refractive Surgery Not yet recruiting NCT03655743

Search NIH Clinical Center for Lens Disease

Cochrane evidence based reviews: lens diseases

Genetic Tests for Lens Disease

Anatomical Context for Lens Disease

MalaCards organs/tissues related to Lens Disease:

40
Eye, Retina, Bone, Ovary, Pancreas, Placenta, Cervix

Publications for Lens Disease

Articles related to Lens Disease:

(show all 36)
# Title Authors PMID Year
1
Modeling ocular lens disease in Xenopus. 61
31872467 2019
2
Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats. 61
31747961 2019
3
Quantitative assessment of early Type 2 diabetic cataracts using T1,T2-mapping techniques. 61
31398062 2019
4
The effects of c-Src kinase on EMT signaling pathway in human lens epithelial cells associated with lens diseases. 61
31703690 2019
5
Endogenous bioelectric currents promote differentiation of the mammalian lens. 61
28661005 2018
6
Whole exome sequencing: Uncovering causal genetic variants for ocular diseases. 61
28844620 2017
7
The Role of DNA Methylation in Lens Development and Cataract Formation. 61
27858287 2017
8
Prevalence of Laboratory Critical Results in Eye Patients from an Eye Hospital in Southern China. 61
28573144 2017
9
Targeted Genes Sequencing Identified a Novel 15 bp Deletion on GJA8 in a Chinese Family with Autosomal Dominant Congenital Cataracts. 61
26996484 2016
10
Ocular neuropathic pain. 61
25943558 2016
11
[Ophthalmic pathology in tubalars of the Altai Republic]. 61
25098120 2014
12
Identification of a novel GJA8 (Cx50) point mutation causes human dominant congenital cataracts. 61
24535056 2014
13
[Epidemiological study of the metabolic diseases with homocystinuria in Spain]. 61
22047794 2012
14
iSyTE: integrated Systems Tool for Eye gene discovery. 61
22323457 2012
15
Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells. 61
22403680 2012
16
Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A. 61
22550388 2012
17
The lens: a classical model of embryonic induction providing new insights into cell determination in early development. 61
21402580 2011
18
[Clinical study of the auxiliary management with iris retractor for subluxated lens combined with cataract]. 61
21418927 2011
19
Analysis of protein-protein interactions and proteomic profiles of normal human lenses. 61
20597647 2010
20
The lens capsule. 61
18773892 2009
21
A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family. 61
18407550 2008
22
[Coverslip assisted primary tissue culture for human lens epithelial cells in vitro]. 61
18709952 2008
23
[Rare complication in microspherophakia surgery: early capsular contraction]. 61
18268433 2007
24
Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q. 61
14512969 2003
25
[The application of digital photography with retroillumination for lens in cataract study]. 61
12892603 2003
26
Knowledge about glaucoma in the unselected population: a German survey. 61
12362089 2002
27
Cataracts in New World camelids (llamas, alpacas, vicuñas, and guanacos). 61
12170638 2002
28
The role of HBV-infection in development of cataracts in children and adults. 61
9361491 1997
29
A locus for autosomal dominant posterior polar cataract on chromosome 1p. 61
9002669 1997
30
Diagnosis and treatment of lens diseases. 61
1458330 1992
31
A guinea-pig hereditary cataract contains a splice-site deletion in a crystallin gene. 61
1390943 1992
32
Documentation of lens diseases. 61
511290 1979
33
[Keratoplasty and combined lens extraction in thirty two non traumatic cases (author's transl)]. 61
152775 1978
34
Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrysotherapy. 61
737001 1978
35
[Disability and rehabilitation in lens diseases]. 61
138113 1976
36
Concomitant progressive deafness, chronic nephritis, and ocular lens disease. 61
13950238 1963

Variations for Lens Disease

Expression for Lens Disease

Search GEO for disease gene expression data for Lens Disease.

Pathways for Lens Disease

GO Terms for Lens Disease

Biological processes related to Lens Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.35 PAX6 GJA3 CRYGS CRYBB2 CRYAA
2 camera-type eye development GO:0043010 9.33 PAX6 FOXE3 CRYBB2
3 cornea development in camera-type eye GO:0061303 9.32 PAX6 FOXE3
4 iris morphogenesis GO:0061072 9.26 PAX6 FOXE3
5 lens development in camera-type eye GO:0002088 8.92 PAX6 FOXE3 CRYGS CRYBB2

Molecular functions related to Lens Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.8 CRYGS CRYBB2 CRYAA

Sources for Lens Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....