Aliases & Classifications for Lens Disease

Summaries for Lens Disease

MalaCards based summary : Lens Disease, also known as lens diseases, is related to cataract and traumatic glaucoma, and has symptoms including eye manifestations An important gene associated with Lens Disease is CRYAA (Crystallin Alpha A). The drugs Estradiol and Estradiol valerate have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 The lens is a transparent, biconvex structure in the eye that, along with the cornea, helps to refract... more...

Related Diseases for Lens Disease

Diseases related to Lens Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 cataract 25.6 AKR1B1 CRYAA CRYAB CRYBA4 CRYBB2 CRYGA
2 traumatic glaucoma 10.9 OPTN PHEX
3 morning glory syndrome 10.9 GJA3 PAX6
4 chronic closed-angle glaucoma 10.8 OPTN PHEX
5 scleral staphyloma 10.8 OPTN PAX6
6 acute closed-angle glaucoma 10.8 OPTN PEX19
7 morgagni cataract 10.7 CRYAA PHEX
8 eye accommodation disease 10.7 CRYAA CRYGS
9 nuclear senile cataract 10.7 CRYAA CRYGS LAMA3
10 glaucoma 3, primary congenital, a 10.7 CRYGS OPTN PAX6
11 juvenile glaucoma 10.7 OPTN PAX6 PHEX
12 presbyopia 10.7 CRYAA CRYGS
13 mature cataract 10.7 CRYAA CRYBB2 CRYGS
14 isolated ectopia lentis 10.6
15 degenerative myopia 10.6 CRYAA VEGFA
16 diabetic cataract 10.6 AKR1B1 GBA3 VEGFA
17 vitreous detachment 10.5 LAMA3 VEGFA
18 cataract-glaucoma 10.5 OCRL PITX3
19 phacogenic glaucoma 10.5 CRYAA OPTN PEX19 PHEX
20 aniridia 1 10.5 FOXE3 OPTN PAX6
21 blood group, globoside system 10.4 CRYAA CRYGS OPTN VEGFA
22 sclerocornea 10.4 FOXE3 OPTN
23 anterior segment dysgenesis 2 10.4 FOXE3 PITX3
24 neovascular glaucoma 10.4 OPTN VEGFA
25 posterior polar cataract 10.3 CRYAB GJA3 PITX3
26 iris disease 10.3 CRYAA OPTN PAX6 PEX19 PHEX
27 cataract 25 10.2 CRYBB2 CRYGS GJA8
28 cataract 9, multiple types 10.2 CRYAA CRYBB2 GJA8
29 cataract 44 10.2 CRYAA CRYBB2 GJA8
30 anterior segment dysgenesis 10.2 FOXE3 PAX6 PITX3
31 cataract 30, multiple types 10.2 CRYBB2 GJA3 GJA8
32 peters-plus syndrome 10.2 FOXE3 PAX6 PITX3
33 anterior segment dysgenesis 1 10.1 CRYGS FOXE3 PAX6 PITX3
34 endophthalmitis 10.0 OPTN VEGFA
35 coloboma of macula 10.0 CRYBA4 FOXE3 OPTN PAX6
36 congenital aphakia 10.0 FOXE3 GJA8 OPTN PAX6
37 microphthalmia 9.9 CRYAA FOXE3 PAX6 PITX3
38 cataract 1, multiple types 9.9 GJA3 GJA8
39 early-onset nuclear cataract 9.7 CRYAA CRYAB CRYBB2 GJA3 GJA8
40 cataract microcornea syndrome 9.7 CRYAA CRYBA4 CRYBB2 GJA8
41 cataract 16, multiple types 9.4 CRYAA CRYAB CRYBA4 CRYGS GJA3 PITX3

Graphical network of the top 20 diseases related to Lens Disease:



Diseases related to Lens Disease

Symptoms & Phenotypes for Lens Disease

UMLS symptoms related to Lens Disease:


eye manifestations

GenomeRNAi Phenotypes related to Lens Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.98 GJA3
2 Decreased viability GR00402-S-2 9.98 LAMA3 MYH9 OCRL AKR1B1 OPTN CRYAA
3 no effect GR00402-S-1 9.62 MYH9 OCRL AKR1B1 OPTN CRYAA PAX6

MGI Mouse Phenotypes related to Lens Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.4 AKR1B1 CRYAB CRYBB2 CRYGA CRYGS GJA3

Drugs & Therapeutics for Lens Disease

Drugs for Lens Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 287)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-28-2 5757
2 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 979-32-8
3
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 35189-28-7 6540478
6
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 28014-46-2
7
Dipivefrin Approved Phase 4,Phase 3,Not Applicable 52365-63-6 3105
8
Loteprednol Approved Phase 4,Phase 3 82034-46-6, 129260-79-3 444025 9865442
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
11
Ketorolac Approved Phase 4,Phase 3,Not Applicable 74103-06-3, 66635-83-4 3826
12
Nepafenac Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 78281-72-8 151075
13
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 9004-61-9 53477741
14
Gabapentin Approved, Investigational Phase 4,Phase 1,Phase 2 60142-96-3 3446
15
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 1,Phase 2 56-12-2 119
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 50-02-2 5743
17
Ephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 299-42-3 9294
18
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 90-82-4 7028
19
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
20
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
21
Midazolam Approved, Illicit Phase 4,Phase 1 59467-70-8 4192
22
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
23
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
24
Vancomycin Approved Phase 4,Phase 3 1404-90-6 441141 14969
25
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
26
Lidocaine Approved, Vet_approved Phase 4,Phase 1,Not Applicable 137-58-6 3676
27
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
28
Dinoprostone Approved Phase 4,Not Applicable 363-24-6 5280360
29
Levofloxacin Approved, Investigational Phase 4,Phase 3,Not Applicable 100986-85-4 149096
30
Ofloxacin Approved Phase 4,Phase 3,Not Applicable 82419-36-1 4583
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3 113775-47-6 68602 5311068
32
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
33
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
34
Azithromycin Approved Phase 4 83905-01-5 55185 447043
35
Gatifloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 112811-59-3 5379
36
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Phase 2 85721-33-1 2764
37
Bimatoprost Approved, Investigational Phase 4,Phase 2 155206-00-1 5311027
38
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
39
Dalteparin Approved Phase 4 9005-49-6
40
Enoxaparin Approved Phase 4 9005-49-6 772
41
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
42
Difluprednate Approved Phase 4,Phase 3 23674-86-4 443936
43
Fluprednisolone Approved Phase 4,Phase 3 53-34-9
44
Brinzolamide Approved Phase 4 138890-62-7 68844
45
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 32986-56-4 5496 36294
46
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
47 Homatropine Approved Phase 4 87-00-3
48
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Not Applicable 1491-59-4 4636
49
Phenylephrine Approved Phase 4,Phase 3,Not Applicable 59-42-7 6041
50
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815

Interventional clinical trials:

(show top 50) (show all 772)
# Name Status NCT ID Phase Drugs
1 Clinical Investigation of the Modified Rayner Monofocal Aspheric 600C (With Axis Marks) Intraocular Lens Unknown status NCT02378636 Phase 4
2 Clinical Investigation of the Bi Flex M Multifocal IOL Unknown status NCT02338882 Phase 4
3 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
4 Evaluation of Clinical Outcomes Following Implantation of a Sub-2mm Hydrophilic MICS Intraocular Lens Unknown status NCT01615861 Phase 4
5 Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery Unknown status NCT01382641 Phase 4
6 Aqueous Absorption and Pharmacokinetics of Besivance Versus VIGAMOX in Patients Undergoing Phacoemulsification Unknown status NCT01296191 Phase 4 Moxifloxacin;besifloxacin
7 AMO's Tecnis™ Multifocal Intraocular Lenses (Tecnis MF), Alcon's ReStor Multifocal IOL Unknown status NCT01278420 Phase 4
8 Efficacy of Subtenon's Block With Olive Tipped Cannula Unknown status NCT01019018 Phase 4
9 Randomized, Masked Comparison of Bromfenac and Besifloxacin BID With Either Prednisolone BID or Loteprednol 0.5% BID for Prevention of Retinal Thickening and CME Following Phacoemulsification Unknown status NCT01193504 Phase 4 Pred Forte;Lotemax
10 Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies Unknown status NCT00865540 Phase 4 prednisolone acetate 1%;ketorolac tromethamine 0.4%;nepafenac 0.1%;methylcellulose 0.5%
11 Combined Phacotube vs Phacotrabeculectomy:A Randomized Controlled Trial Unknown status NCT00273221 Phase 4
12 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
13 Effect of Gabapentin on Pain of the Second Cataract Surgery Unknown status NCT02127853 Phase 4 gabapentin;placebo
14 Spherical Aberration and Contrast Sensitivity in IOLs Completed NCT00576485 Phase 4
15 Sedation Methods During Cataract Surgery Completed NCT03054103 Phase 4 Midazolam + Ketamine 10 MG/ML: 0.5 ML;Midazolam + Ketamine 10 MG/ML: 1 ML;Midazolam + Normal saline
16 Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia Completed NCT02771912 Phase 4 Propofol;Placebo
17 Clinical Outcomes After Bilateral Implantation of ZEISS AT LISA TRI AND TRI TORIC IOL Completed NCT02770924 Phase 4
18 Visual Acuity After the Combined Binocular Implantation of +2.0 Diopters and +3.0 Diopters Oculentis Multifocal Intraocular Lenses. Completed NCT02633228 Phase 4
19 Visual Acuity After the Combined Binocular Implantation of +2.75 Diopters and +3.25 Diopters Tecnis Multifocal Intraocular Lenses. Completed NCT02633072 Phase 4
20 Dropless vs. Standard Drops Contralateral Eye Study Completed NCT02515045 Phase 4 TriMoxiVanc;Moxifloxacin HCl 0.5%;Ilevro;Prednisolone acetate 1%
21 Visual Acuity After the Combined Binocular Implantation of +2.5 Diopters and +3.0 Diopters ReSTOR Multifocal Intraocular Lenses. Completed NCT02314572 Phase 4
22 A Comparison of One-site and Two-site Peribulbar Anaesthesia for Cataract Surgery at Kaduna, Nigeria Completed NCT02150460 Phase 4
23 Parameters of 2 Phaco Tips Designs in Torsional Phacoemulsification Completed NCT02089698 Phase 4
24 Long-term (3 Months) Safety of Femtosecond-laser Assisted Cataract Surgery Completed NCT02023437 Phase 4
25 Addressing of Efficacy and Safety of Femtosecond-laser Assisted Versus Manual Lens Fragmentation Procedure Completed NCT01971177 Phase 4
26 Pharmacokinetic Evaluation of Moxifloxacin in Vigadexa® in Aqueous Humor Samples Following Preoperative Antibiotic/Steroid Dosing in Cataract Surgery Patients Completed NCT01859702 Phase 4 Moxifloxacin 0.5%/Dexamethasone 0.1% ophthalmic solution
27 A Single Centre Study to Analyze Cataract Surgery Following Femtosecond Laser-Assisted and Manual Cataract Surgery Completed NCT01769313 Phase 4
28 Time Study for Biometry Measurements With the Lenstar and IntraOcularLens (IOL) Master 500 Completed NCT01550939 Phase 4
29 Visual Outcomes After Implantation of a New Multifocal Intraocular Lens Completed NCT01505816 Phase 4
30 2-Site Safety Study of Besivance Versus Vigamox Prophylactically in Routine Cataract Surgery Completed NCT01455233 Phase 4 besivance;vigamox
31 Laser Cataract Surgery With the Femtosecond Laser Technology Completed NCT01382823 Phase 4
32 Dispervise Ophthalmic Viscoelastic as an Agent to Ensure Watertight Wound Closure After Clear Corneal Cataract Incisions Completed NCT01298973 Phase 4 Viscoat;Saline
33 Comparison of Postoperative Visual Acuity and Spectacle Independence Between the Tecnis Multifocal Intraoculer Lens (IOL) and the Crystalens Accommodating IOL Completed NCT01275118 Phase 4
34 Evaluation of Effective Lens Position With a Uniplanar Bi-aspheric IOL Completed NCT01248572 Phase 4
35 Clinical Evaluation of the One-Piece Tecnis Multifocal Intraocular Lens (IOL) Completed NCT01210807 Phase 4
36 Efficacy Evaluation of SYSTANE® ULTRA in Patients Scheduled for Cataract Surgery Completed NCT01199510 Phase 4
37 Evaluation of 3 Intraocular Lenses Following Lens Extraction Completed NCT01122576 Phase 4
38 Evaluation Of Bilateral Tecnis Multifocal Versus ReSTOR 3D Intraocular Lenses Completed NCT01061918 Phase 4
39 Evaluation of the Tecnis™ Multifocal and Crystalens™ Accommodating Intraocular Lenses Completed NCT01061281 Phase 4
40 Spherical Aberration and Contrast Sensitivity Function in Eyes Implanted With Spherical and Aspheric Intraocular Lenses: A Clinical Trial Completed NCT01028872 Phase 4
41 A Comparison of Prostaglandin E2 (PGE2) Inhibition of Acuvail(Ketorolac 0.45%), Xibrom (Bromfenac 0.09%)and Nevanac (Nepafenac)in Patients Undergoing Phacoemulsification Completed NCT01021761 Phase 4 Ketorolac Tromethamine;Bromfenac;nepafenac
42 Outcomes of Phacoemulsification With Torsional Ultrasound Completed NCT01010490 Phase 4
43 A Comparison of Peak Aqueous Penetration of Acuvail (Ketorolac 0.45%), Xibrom (Bromfenac 0.09%), and Nevanac (Nepafenac 0.1%)in Patients Undergoing Phacoemulsification Completed NCT01001806 Phase 4 Ketorolac Tromethamine 0.45%;bromfenac 0.09%;nepafenac 0.1%
44 Selection of Aspheric Diffractive Multifocal Intraocular Lens (IOLS) Based on Corneal Wavefront Completed NCT00999492 Phase 4
45 Visual Function After Implantation of Bilateral AcrySoft ReSTOR Aspheric IOL Completed NCT00934622 Phase 4
46 Check of Optical Features and Accuracy of the Zeiss ZO Lens After Selection and Calculation With OKULIX Completed NCT00842959 Phase 4
47 Effect on Wound Healing of Vigamox Versus Cravit Completed NCT00840580 Phase 4 Moxifloxacin 0.5% ophthalmic solution (Vigamox);Levofloxacin 0.5% ophthalmic solution (Cravit)
48 Evaluation of the Safety & Effectiveness of the Bausch & Lomb AKREOS® TL Intraocular Lens Completed NCT00838045 Phase 4
49 Visual Function Evaluation of Bilateral AcrySof ReSTOR Aspheric IOL Completed NCT00818116 Phase 4
50 Clinical Evaluation of a New Aspheric Intraocular Lens. Completed NCT00786565 Phase 4

Search NIH Clinical Center for Lens Disease

Cochrane evidence based reviews: lens diseases

Genetic Tests for Lens Disease

Anatomical Context for Lens Disease

MalaCards organs/tissues related to Lens Disease:

41
Eye, Endothelial, Retina, Testes, Bone, Prostate

Publications for Lens Disease

Articles related to Lens Disease:

# Title Authors Year
1
Concomitant progressive deafness, chronic nephritis, and ocular lens disease. ( 13950238 )
1963

Variations for Lens Disease

Expression for Lens Disease

Search GEO for disease gene expression data for Lens Disease.

Pathways for Lens Disease

GO Terms for Lens Disease

Cellular components related to Lens Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 connexin complex GO:0005922 8.62 GJA3 GJA8

Biological processes related to Lens Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.83 AKR1B1 CRYAA CRYAB FOXE3 VEGFA
2 visual perception GO:0007601 9.7 CRYAA CRYBA4 CRYBB2 CRYGA GJA3 GJA8
3 protein stabilization GO:0050821 9.62 CRYAA CRYAB GBA3 PEX19
4 dopaminergic neuron differentiation GO:0071542 9.52 PITX3 VEGFA
5 positive regulation of neuroblast proliferation GO:0002052 9.51 PAX6 VEGFA
6 negative regulation of neurogenesis GO:0050768 9.49 PAX6 PITX3
7 eye photoreceptor cell development GO:0042462 9.48 PAX6 VEGFA
8 monocyte differentiation GO:0030224 9.46 MYH9 VEGFA
9 camera-type eye development GO:0043010 9.43 CRYAB CRYBA4 CRYBB2 FOXE3 GJA8 PAX6
10 iris morphogenesis GO:0061072 9.4 FOXE3 PAX6
11 cornea development in camera-type eye GO:0061303 9.37 FOXE3 PAX6
12 negative regulation of intracellular transport GO:0032387 9.26 CRYAA CRYAB
13 lens development in camera-type eye GO:0002088 9.17 CRYAB CRYGA CRYGS FOXE3 GJA8 PAX6

Molecular functions related to Lens Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 9.1 CRYAA CRYAB CRYBA4 CRYBB2 CRYGA CRYGS
2 gap junction channel activity GO:0005243 8.96 GJA3 GJA8

Sources for Lens Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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