MCID: LNS003
MIFTS: 33

Lens Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lens Disease

Summaries for Lens Disease

Disease Ontology : 12 An eye disease that affects the lens of the eye, which is the transparent disc that focuses light to the photosensors in the back of the eye.

MalaCards based summary : Lens Disease, also known as lens diseases, is related to cataract and rare lens disease, and has symptoms including eye manifestations An important gene associated with Lens Disease is CRYAA (Crystallin Alpha A). Affiliated tissues include eye and retina, and related phenotype is vision/eye.

Wikipedia : 73 The lens is a transparent biconvex structure in the eye that, along with the cornea, helps to refract... more...

Related Diseases for Lens Disease

Diseases in the Lens Disease family:

Rare Lens Disease

Diseases related to Lens Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 cataract 31.5 WRN VEGFA TRNT1 PAX6 OCRL MIR204
2 rare lens disease 11.0
3 isolated ectopia lentis 10.8
4 retinal microaneurysm 10.6 VEGFA INS AKR1B1
5 congenital aphakia 10.6 PAX6 FOXE3 CRYAA
6 severe nonproliferative diabetic retinopathy 10.6 VEGFA INS AKR1B1
7 vitreous disease 10.6 VEGFA PAX6 CRYAA
8 disuse amblyopia 10.6 FOXE3 CRYGS CRYAA
9 aniseikonia 10.6 PAX6 OCRL FOXE3
10 kuhnt-junius degeneration 10.6 VEGFA CRYAA CFHR2
11 background diabetic retinopathy 10.6 VEGFA INS AKR1B1
12 cataract 9, multiple types 10.6 GJA8 CRYBB2 CRYAA
13 eye accommodation disease 10.6 FOXE3 CRYGS CRYAA
14 axenfeld-rieger syndrome, type 1 10.6 PAX6 FOXE3 CRYAA
15 early-onset sutural cataract 10.6 GJA8 CRYGS CRYBB2
16 intravascular papillary endothelial hyperplasia 10.6 VEGFA SERPINA3
17 cataract 44 10.6 GJA8 CRYBB2 CRYAA
18 doyne honeycomb retinal dystrophy 10.6 ERCC6 CRYAA CFHR2
19 congenital nystagmus 10.5 PAX6 GJA8 CRYAA
20 multicentric castleman disease 10.5 VEGFA H2AC18 CFHR2
21 macular retinal edema 10.5 VEGFA INS CRYAA AKR1B1
22 diabetic polyneuropathy 10.5 VEGFA INS AKR1B1
23 syndromic microphthalmia 10.5 PAX6 H2AC18 CRYAA
24 drug-induced lupus erythematosus 10.5 VEGFA H2AC18 GAPDH
25 early-onset nuclear cataract 10.5 GJA8 CRYBB2 CRYAA
26 carbohydrate metabolic disorder 10.5 INS H2AC18 ERCC6 CRYAA
27 juvenile glaucoma 10.5 PAX6 FOXE3 CRYAA
28 myotonic disease 10.5 ERCC6 DMPK CNBP
29 physical disorder 10.5 PAX6 H2AC18 ERCC6 CRYAA
30 fanconi anemia, complementation group j 10.5 WRN H2AC18 ERCC6
31 telangiectasis 10.5 VEGFA H2AC18 ERCC6
32 retinal perforation 10.5 VEGFA CRYGS CRYBB2 CRYAA
33 immature cataract 10.5 GJA8 DMPK CRYAA CNBP
34 sexual disorder 10.5 VEGFA INS H2AC18
35 primary congenital glaucoma 10.5 PAX6 FOXE3 CRYAA
36 actinomycosis 10.5 INS H2AC18 GAPDH
37 sclerocornea 10.5 PAX6 GJA8 FOXE3 CRYAA
38 anterior segment dysgenesis 1 10.5 PAX6 GJA8 FOXE3
39 nance-horan syndrome 10.5 GJA8 CRYBB2 CRYAA
40 progressive relapsing multiple sclerosis 10.5 SERPINA3 H2AC18 CFHR2
41 senile cataract 10.5 WRN CRYGS CRYAA
42 lymphangioma 10.5 VEGFA SERPINA3 H2AC18 ERCC6
43 cataract microcornea syndrome 10.5 GJA8 CRYBB2 CRYAA
44 esotropia 10.5 PAX6 FOXE3 CRYAA
45 microvascular complications of diabetes 1 10.5 VEGFA INS CRYAA AKR1B1
46 intestinal benign neoplasm 10.5 VEGFA SERPINA3 H2AC18 ERCC6
47 diabetic cataract 10.5 VEGFA MIR204 CRYGS CRYAA AKR1B1
48 retroperitoneal hemangiopericytoma 10.5 VEGFA INS
49 persistent hyperplastic primary vitreous 10.5 VEGFA PAX6 FOXE3 CRYGS
50 keratitis, hereditary 10.5 VEGFA PAX6 FOXE3 CRYAA

Graphical network of the top 20 diseases related to Lens Disease:



Diseases related to Lens Disease

Symptoms & Phenotypes for Lens Disease

UMLS symptoms related to Lens Disease:


eye manifestations

MGI Mouse Phenotypes related to Lens Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.36 AKR1B1 CNBP CRYBB2 CRYGS ERCC6 GJA8

Drugs & Therapeutics for Lens Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Spherical Aberration and Contrast Sensitivity in Eyes Implanted With Aspheric and Spherical Intraocular Lenses: Clinical Comparative Study Completed NCT00576485 Phase 4
2 The Possible Association Between Pseudoexfoliation Syndrome and Diabetes Mellitus in an Egyptian Population Unknown status NCT03741153
3 Visual Performance of Pseudophakic Patient With Different Intraocular Lenses Unknown status NCT01763411
4 Development of a New Patient Reported Outcome (PRO) Measure for Refractive Surgery Patients as Part of the National Dataset in Refractive Surgery Unknown status NCT03655743
5 Refinement of the Magnetic Resonance Imaging Technique for the Study of the Normal Eye, Particularly the Lens and Cataract Completed NCT00005911
6 Study of the Incidence of Retinal Detachment After Lens Surgery in the Nearsighted Completed NCT04072939

Search NIH Clinical Center for Lens Disease

Cochrane evidence based reviews: lens diseases

Genetic Tests for Lens Disease

Anatomical Context for Lens Disease

MalaCards organs/tissues related to Lens Disease:

40
Eye, Retina

Publications for Lens Disease

Articles related to Lens Disease:

(show all 37)
# Title Authors PMID Year
1
Compliance behaviour change in contact lens wearers: a randomised controlled trial. 61
32546749 2021
2
Modeling ocular lens disease in Xenopus. 61
31872467 2020
3
The effects of c-Src kinase on EMT signaling pathway in human lens epithelial cells associated with lens diseases. 61
31703690 2019
4
Quantitative assessment of early Type 2 diabetic cataracts using T1,T2-mapping techniques. 61
31398062 2019
5
Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats. 61
31747961 2019
6
Endogenous bioelectric currents promote differentiation of the mammalian lens. 61
28661005 2018
7
Whole exome sequencing: Uncovering causal genetic variants for ocular diseases. 61
28844620 2017
8
The Role of DNA Methylation in Lens Development and Cataract Formation. 61
27858287 2017
9
Prevalence of Laboratory Critical Results in Eye Patients from an Eye Hospital in Southern China. 61
28573144 2017
10
Targeted Genes Sequencing Identified a Novel 15 bp Deletion on GJA8 in a Chinese Family with Autosomal Dominant Congenital Cataracts. 61
26996484 2016
11
Ocular neuropathic pain. 61
25943558 2016
12
[Ophthalmic pathology in tubalars of the Altai Republic]. 61
25098120 2014
13
Identification of a novel GJA8 (Cx50) point mutation causes human dominant congenital cataracts. 61
24535056 2014
14
iSyTE: integrated Systems Tool for Eye gene discovery. 61
22323457 2012
15
[Epidemiological study of the metabolic diseases with homocystinuria in Spain]. 61
22047794 2012
16
Efficient generation of lens progenitor cells from cataract patient-specific induced pluripotent stem cells. 61
22403680 2012
17
Spatial expression of aquaporin 5 in mammalian cornea and lens, and regulation of its localization by phosphokinase A. 61
22550388 2012
18
The lens: a classical model of embryonic induction providing new insights into cell determination in early development. 61
21402580 2011
19
[Clinical study of the auxiliary management with iris retractor for subluxated lens combined with cataract]. 61
21418927 2011
20
Analysis of protein-protein interactions and proteomic profiles of normal human lenses. 61
20597647 2010
21
The lens capsule. 61
18773892 2009
22
A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family. 61
18407550 2008
23
[Coverslip assisted primary tissue culture for human lens epithelial cells in vitro]. 61
18709952 2008
24
[Rare complication in microspherophakia surgery: early capsular contraction]. 61
18268433 2007
25
Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q. 61
14512969 2003
26
[The application of digital photography with retroillumination for lens in cataract study]. 61
12892603 2003
27
Knowledge about glaucoma in the unselected population: a German survey. 61
12362089 2002
28
Cataracts in New World camelids (llamas, alpacas, vicuñas, and guanacos). 61
12170638 2002
29
The role of HBV-infection in development of cataracts in children and adults. 61
9361491 1997
30
A locus for autosomal dominant posterior polar cataract on chromosome 1p. 61
9002669 1997
31
Diagnosis and treatment of lens diseases. 61
1458330 1992
32
A guinea-pig hereditary cataract contains a splice-site deletion in a crystallin gene. 61
1390943 1992
33
Documentation of lens diseases. 61
511290 1979
34
[Keratoplasty and combined lens extraction in thirty two non traumatic cases (author's transl)]. 61
152775 1978
35
Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrysotherapy. 61
737001 1978
36
[Disability and rehabilitation in lens diseases]. 61
138113 1976
37
Concomitant progressive deafness, chronic nephritis, and ocular lens disease. 61
13950238 1963

Variations for Lens Disease

Expression for Lens Disease

Search GEO for disease gene expression data for Lens Disease.

Pathways for Lens Disease

GO Terms for Lens Disease

Biological processes related to Lens Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.46 CRYAA CRYBB2 CRYGS PAX6
2 cornea development in camera-type eye GO:0061303 9.32 FOXE3 PAX6
3 iris morphogenesis GO:0061072 9.26 FOXE3 PAX6
4 camera-type eye development GO:0043010 9.26 CRYBB2 FOXE3 GJA8 PAX6
5 lens development in camera-type eye GO:0002088 9.02 CRYBB2 CRYGS FOXE3 GJA8 PAX6

Molecular functions related to Lens Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-quadruplex DNA binding GO:0051880 8.96 WRN CNBP
2 structural constituent of eye lens GO:0005212 8.8 CRYAA CRYBB2 CRYGS

Sources for Lens Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....