Lens Subluxation disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNS001 MIFTS: 38	Lens Subluxation Categories: Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Lens Subluxation

MalaCards integrated aliases for Lens Subluxation:

Name: Lens Subluxation ¹² ²⁹ ⁵⁴ ⁶ ¹⁵ ⁷¹

Subluxation of Lens ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11364

ICD9CM ³⁴ 379.32

MeSH ⁴³ D007906 {http

NCIt ⁴⁹ C34772

SNOMED-CT ⁶⁷ 65814009

ICD10 ³² H27.11

UMLS ⁷¹ C0023316

Sources

Summaries for Lens Subluxation

MalaCards based summary : Lens Subluxation, also known as subluxation of lens, is related to isolated ectopia lentis and homocystinuria. An important gene associated with Lens Subluxation is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Degradation of the extracellular matrix and O-glycosylation of TSR domain-containing proteins. The drugs Fentanyl and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and testes, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : ⁷⁴ Ectopia lentis is a displacement or malposition of the eye's crystalline lens from its normal location.... more...

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Related Diseases for Lens Subluxation

Diseases related to Lens Subluxation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)

#	Related Disease	Score	Top Affiliating Genes
1	isolated ectopia lentis	32.8	LTBP2 FBN1 CBS ADAMTSL4 ADAMTS17 ADAMTS10
2	homocystinuria	30.7	MTHFR FBN1 CRYAA CBS
3	homocysteinemia	30.6	MTHFR FBN1 CBS
4	marfan syndrome	30.5	MTHFR LTBP2 LOXL1 FBN1 CBS
5	acute closed-angle glaucoma	30.4	PEX19 LAMA3
6	phimosis	30.3	PEX19 CRYAA
7	coloboma of macula	30.3	VSX2 TFAP2A PAX6 CRYAA
8	retinal detachment	30.1	PAX6 P3H2 ADAMTSL4
9	megalocornea	30.1	LTBP2 FBN1 ADAMTS17 ADAMTS10
10	intraocular pressure quantitative trait locus	30.0	PEX19 PAX6 LTBP2 LOXL1 FBN1 CRYAA
11	amblyopia	29.9	TFAP2A PAX6 CRYAA BFSP1
12	corneal edema	29.9	MPDU1 LTBP2 LAMA3
13	open-angle glaucoma	29.8	MTHFR LTBP2 LOXL1 CRYAA
14	aniridia 1	29.8	VSX2 PAX6 LTBP2 CRYAA
15	myopia	29.6	PAX6 P3H2 LTBP2 FBN1 CRYAA ADAMTS17
16	primary congenital glaucoma	29.3	PAX6 LTBP2 LOXL1 FBN1 CRYAA ADAMTS10
17	cataract	28.5	VSX2 PAX6 P3H2 MTHFR LOXL1 GALT
18	myopia, high, with cataract and vitreoretinal degeneration	11.6
19	late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome	11.3
20	coloboma of iris	10.4	TFAP2A PAX6
21	fryns microphthalmia syndrome	10.4	VSX2 PAX6
22	branch retinal artery occlusion	10.4	MTHFR CRYAA
23	congenital aphakia	10.4	VSX2 PAX6
24	leukocoria	10.4	VSX2 CRYAA
25	cutis laxa, autosomal recessive, type ia	10.4	LOXL1 FBN1
26	enophthalmos	10.4	TFAP2A FBN1 CRYAA
27	orbital disease	10.4	TFAP2A FBN1 CRYAA
28	microphthalmia, isolated 3	10.4	VSX2 PAX6
29	glaucoma-related pigment dispersion syndrome	10.3	PEX19 LOXL1
30	joint laxity, short stature, and myopia	10.3
31	central retinal artery occlusion	10.3	MTHFR CRYAA
32	immature cataract	10.3	MPDU1 CRYAA
33	exfoliation syndrome	10.3	MTHFR LOXL1 FBN1
34	colobomatous microphthalmia	10.3	VSX2 TFAP2A PAX6
35	retinal vascular occlusion	10.3	MTHFR LOXL1 CRYAA
36	geleophysic dysplasia 1	10.3	LTBP2 FBN1
37	tracheal disease	10.3	FBN1 ADAMTS17 ADAMTS10
38	isolated microspherophakia	10.3	LTBP2 ADAMTS10
39	exotropia	10.3	PAX6 FBN1 CRYAA
40	geleophysic dysplasia 2	10.3	LTBP2 FBN1
41	axenfeld-rieger syndrome, type 3	10.2	VSX2 PAX6 CRYAA
42	esotropia	10.2	TFAP2A PAX6 CRYAA
43	syndromic microphthalmia	10.2	VSX2 PAX6 CRYAA
44	coloboma, ocular, autosomal dominant	10.2	TFAP2A PAX6
45	ectopia lentis 1, isolated, autosomal dominant	10.2	FBN1 ADAMTSL4 ADAMTS10
46	ectopia lentis 2, isolated, autosomal recessive	10.2	FBN1 ADAMTSL4 ADAMTS10
47	steroid-induced glaucoma	10.2	PEX19 CRYAA
48	weill-marchesani syndrome 1	10.2	LTBP2 ADAMTS10
49	axenfeld-rieger syndrome, type 1	10.2	PAX6 CRYAA
50	nanophthalmos	10.2	VSX2 PAX6 LOXL1

Graphical network of the top 20 diseases related to Lens Subluxation:

Sources

Symptoms & Phenotypes for Lens Subluxation

GenomeRNAi Phenotypes related to Lens Subluxation according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00240-S-1	9.74	ADAMTS17
2	Decreased viability	GR00249-S	9.74	ADAMTS10 CRYAA GALT LTBP2 TFAP2A
3	Decreased viability	GR00381-A-1	9.74	ADAMTS10 ADAMTS17 GALT IQCK P3H2
4	Decreased viability	GR00381-A-2	9.74	ADAMTS17
5	Decreased viability	GR00381-A-3	9.74	ADAMTS17
6	Decreased viability	GR00386-A-1	9.74	GALT LOXL1 MTHFR PAX6 PEX19
7	Decreased viability	GR00402-S-2	9.74	ADAMTS17 CRYAA CRYBA2 FBN1 GALT IQCK

MGI Mouse Phenotypes related to Lens Subluxation:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.76	ADAMTS10 ADAMTSL4 FBN1 LAMA3 LOXL1 MTHFR
2	vision/eye	MP:0005391	9.36	ADAMTS10 ADAMTSL4 BFSP1 CRYBA2 LOXL1 LTBP2
3	pigmentation	MP:0001186	9.35	ADAMTSL4 FBN1 PAX6 TFAP2A VSX2

Sources

Drugs & Therapeutics for Lens Subluxation

Drugs for Lens Subluxation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Synonyms:

1-Phenethyl-4-(N-phenylpropionamido)piperidine

1-phenethyl-4-N-propionylanilinopiperidine

1-Phenethyl-4-N-propionylanilinopiperidine

437-38-7

5-22-08-00049 (Beilstein Handbook Reference)

80832-90-2

990-73-8 (citrate)

AC1L1FQ2

Actiq

BIDD:GT0555

BRN 0494484

Cephalon brand OF fentanyl buccal oravescent

CHEBI:119915

CHEMBL596

CID3345

D00320

DB00813

Duragesic

Duragesic (TN)

Duragesic-100

Duragesic-12

Duragesic-25

Duragesic-50

Duragesic-75

Durogesic

EINECS 207-113-6

Fentanest

Fentanil

Fentanil [DCIT]

Fentanila

Fentanila [INN-Spanish]

Fentanilo

fentanyl

Fentanyl

Fentanyl (JAN/USAN/INN)

Fentanyl [INN:BAN]

Fentanyl CII

Fentanyl citrate

Fentanyl-100

Fentanyl-12

Fentanyl-25

Fentanyl-50

Fentanyl-75

Fentanylum

Fentanylum [INN-Latin]

Fentora

HSDB 3329

IONSYS

Janssen pharmaceutica brand OF fentanyl

JNS020QD

L001275

LS-124439

Matrifen

MolPort-003-847-369

N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide

N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide

N-(1-phenethyl-4-piperidyl)propionanilide

N-(1-Phenethyl-4-piperidyl)propionanilide

N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide

N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide

N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide

N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide

Nasalfent

NCGC00168252-01

N-phenethyl-4-(N-propionylanilino)piperidine

N-Phenethyl-4-(N-propionylanilino)piperidine

N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide

N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide

N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

Oprea1_152073

Oprea1_207148

PDSP1_000860

PDSP2_000846

Pentanyl

Phentanyl

Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)

R 4263

Rapinyl

Sentonil

Sublimase

Sublimaze

Transmucosal oral fentanyl citrate

UNII-UF599785JZ

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Synonyms:

4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate

59467-70-8

8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride

8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine

8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine

AC-18749

AC1L1HMA

BIDD:GT0647

BRN 0625572

Buccolam

C07524

C18H13ClFN3

CHEMBL655

CID4192

D00550

Dazolam

DB00683

Dea no. 2884

Dea No. 2884

DEA No. 2884

Dormicum

Dormicum (TN)

EINECS 261-774-5

Hydrochloride, midazolam

LS-77780

Maleate, midazolam

Midanium

midazolam

Midazolam

Midazolam (JAN/INN)

Midazolam [INN:BAN:JAN]

Midazolam base

Midazolam Base

Midazolam Hcl

Midazolam hydrochloride

Midazolam maleate

Midazolamum

Midazolamum [INN-Latin]

Midosed

MolPort-003-849-219

NCGC00168254-01

nchembio747-comp32

Ro 21-3981

TL8003787

UC429_SIGMA

UNII-R60L0SM5BC

Versed

ZINC00001732

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Synonyms:

2, 6-Diisopropylphenol

2,6 Diisopropylphenol

2,6-bis(1-methylethyl)phenol

2,6-bis(1-methylethyl)-phenol

2,6-Bis(1-methylethyl)phenol

2,6-Bis(Isopropyl)-phenol

2,6-di(propan-2-yl)phenol

2,6-Diisopropyl phenol

2,6-Diisopropylphenol

2,6-DIISOPROPYLPHENOL

2078-54-8

28449-97-0

4-06-00-03435 (Beilstein Handbook Reference)

50356-15-5

AB00513968

Abbott brand OF propofol

Abbott Brand of Propofol

AC1L1J9Y

AC1Q1OUI

AC-2038

AI3-26295

Alpha Brand of Propofol

Alpha Brand OF propofol

AM-149

Ampofol

Aquafol

Astra brand OF propofol

Astra Brand of Propofol

AstraZeneca brand OF propofol

AstraZeneca Brand of Propofol

BIDD:GT0436

Biomol-NT_000248

BPBio1_000950

BPBio1_000969

Braun brand OF propofol

Braun Brand of Propofol

BRD-K82255054-001-03-5

BRN 1866484

BSPBio_000862

C07523

C12H18O

CAS-2078-54-8

CCRIS 9000

CHEBI:44915

CHEMBL526

CID4943

CPD000059151

CPD-11437

Curamed brand OF propofol

Curamed Brand of Propofol

D00549

D015742

D0617

D126608

D126608_ALDRICH

DB00818

DDS-04F

Diisopropylphenol

Dipravan

Diprivan

Diprivan (TN)

Diprivan Injectable emulsion

Disoprivan

Disoprofol

EINECS 218-206-6

EU-0100437

Fresenius brand OF propofol

Fresenius Brand of Propofol

Fresenius kabi brand OF propofol

Fresenius Kabi Brand of Propofol

Fresofol

ghl.PD_Mitscher_leg0.558

HMS1570L04

HMS2089O21

HMS2094E17

HSDB 7123

ICI 35,868

ICI 35868

ICI35,868

ICI-35,868

ICI35868

ICI-35868

InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H

Ivofol

Jsp004266

Juste brand OF propofol

Juste Brand of Propofol

Lopac0_000437

Lopac-D126608

LS-996

MLS001066348

MLS001335999

MLS002454360

MolPort-001-794-517

NCGC00015389-01

NCGC00015389-02

NCGC00015389-04

NCGC00015389-09

NCGC00091538-01

NCGC00091538-02

NCGC00091538-03

NCGC00091538-04

NCGC00091538-05

NCGC00091538-06

nchembio.552-comp7

NSC 5105

NSC5105

Parnell brand OF propofol

Parnell Brand of Propofol

PFL

Pisa brand OF propofol

Pisa Brand of Propofol

Prestwick0_000931

Prestwick1_000931

Prestwick2_000931

Prestwick3_000931

propofol

Propofol

Propofol (JAN/USAN/INN)

Propofol [USAN:INN:BAN]

Propofol abbott

Propofol Abbott

Propofol fresenius

Propofol Fresenius

Propofol IDD-D

Propofol MCT

Propofol rovi

Propofol Rovi

Propofol(2,6-Diisopropylphenol)

Propofol-lipuro

Propofol-Lipuro

Propofolum

Propofolum [Latin]

Rapinovet

Recofol

Rovi brand OF propofol

Rovi Brand of Propofol

S01-0189

SAM002264610

Schering brand OF propofol

Schering Brand of Propofol

SMR000059151

SPBio_003031

SPECTRUM1505022

ST50405911

UNII-YI7VU623SF

W505102_ALDRICH

ZD-0859

Zeneca brand OF propofol

Zeneca Brand of Propofol

ZINC00968303

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Synonyms:

.alpha.-(Diethylamino)-2,6-acetoxylidide

.alpha.-Diethylamino-2,6-dimethylacetanilide

.alpha.-Diethylaminoaceto-2,6-xylidide

.omega.-Diethylamino-2,6-dimethylacetanilide

137-58-6

2-(diethylamino)-2',6'-Acetoxylidide

2-(Diethylamino)-2',6'-acetoxylidide

2-(diethylamino)-N-(2,6-Dimethylphenyl)acetamide

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

2-2ETN-2MePhAcN

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide

2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide

4-12-00-02538 (Beilstein Handbook Reference)

6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))

6108-05-0 (mono-hydrochloride, mono-hydrate)

73-78-9 (mono-hydrochloride)

AB00053581

AC-10282

AC1L1GGQ

AC1Q2Z7J

a-diethylamino-2,6-Dimethylacetanilide

After Burn Double Strength Gel

After Burn Double Strength Spray

After Burn Gel

After Burn Spray

AKOS001026768

alfa-Dietilamino-2,6-dimetilacetanilide

alfa-Dietilamino-2,6-dimetilacetanilide [Italian]

Alphacaine

alpha-diethylamino-2,6-dimethylacetanilide

alpha-diethylamino-2,6-Dimethylacetanilide

alpha-Diethylamino-2,6-dimethylacetanilide

Anestacon

Anestacon Jelly

ARONIS23855

Astrazeneca brand OF lidocaine

BIDD:GT0342

Bio-0767

Bio1_000379

Bio1_000868

Bio1_001357

Bio2_000079

Bio2_000559

BPBio1_000197

BRD-K52662033-001-02-6

BRD-K52662033-003-05-5

BRN 2215784

BSPBio_000179

BSPBio_001359

BSPBio_003004

C07073

C14H22N2O

Cappicaine

CAS-73-78-9

CDS1_000283

CHEBI:6456

CHEMBL79

CID3676

Cito optadren

CPD000058189

Cuivasil

D00358

Dalcaine

DB00281

Dentipatch

Dentipatch (TN)

DermaFlex

Diethylaminoaceto-2,6-xylidide

Dilocaine

DivK1c_000174

DivK1c_001323

Duncaine

EINECS 205-302-8

ELA-Max

EMBOLEX

Emla Cream

Esracaine

FT-0082378

Gravocain

HMS1791D21

HMS1989D21

HMS2051C21

HMS2089E15

HMS548M19

HSDB 3350

I01-2704

IDI1_000174

IDI1_033829

Isicaina

Isicaine

Jenapharm brand OF lidocanine hydrochloride

Jetocaine

KBio1_000174

KBio2_000079

KBio2_001598

KBio2_002647

KBio2_004166

KBio2_005215

KBio2_006734

KBio3_000157

KBio3_000158

KBio3_002224

KBioGR_000079

KBioGR_000599

KBioSS_000079

KBioSS_001598

L0156

L1026_SIGMA

L7757_SIGMA

Lanabiotic

L-Caine

Leostesin

Lida-Mantle

Lidocaina

Lidocaína

Lidocaina [INN-Spanish]

lidocaine

Lidocaine

LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)

Lidocaine (JP15/USP/INN)

Lidocaine (VAN)

Lidocaine [USAN:INN:JAN]

Lidocaine carbonate

Lidocaine Carbonate

Lidocaine carbonate (2:1)

Lidocaine hydrocarbonate

Lidocaine Hydrocarbonate

Lidocaine hydrochloride

Lidocaine monoacetate

Lidocaine monohydrochloride

Lidocaine Monohydrochloride

Lidocaine monohydrochloride, monohydrate

Lidocaine sulfate (1:1)

Lidocainum

Lidocainum [INN-Latin]

Lidocaton

Lidoderm

Lidoject-1

Lidoject-2

LIDOPEN

Lignocaine

Lignocainum

Lingocaine

Lopac0_000669

Lopac-L-5647

LQZ

LS-805

Maricaine

Maybridge1_002571

MLS000069724

MLS000758263

MLS001074177

MolPort-001-783-478

N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide

N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide

NCGC00015611-01

NCGC00015611-02

NCGC00015611-03

NCGC00015611-04

NCGC00015611-14

NCGC00022176-05

NCGC00022176-06

NCGC00022176-07

NCGC00022176-08

NCGC00022176-09

nchembio.65-comp16

NINDS_000174

Norwood Sunburn Spray

Novocol brand OF lidocaine hydrochloride

NSC 40030

NSC40030

Octocaine

Octocaine-100

Octocaine-50

Prestwick0_000050

Prestwick1_000050

Prestwick2_000050

Prestwick3_000050

Remicaine

Rocephin Kit

Rucaina

S1357_Selleck

SAM001247018

SMR000058189

Solarcaine aloe extra burn relief cream

Solcain

SPBio_001525

SPBio_002100

Spectrum_001118

Spectrum2_001343

Spectrum3_001392

Spectrum4_000070

Spectrum5_001549

STK552033

Strathmann brand OF lidocaine hydrochloride

UNII-98PI200987

WLN: 2N2 & 1VMR B1 F1

Xilina

Xilocaina

Xilocaina [Italian]

Xllina

Xycaine

Xylestesin

Xylesthesin

Xylocain

Xylocaine

Xylocaine (TN)

Xylocaine 5% Spinal

Xylocaine CO2

Xylocaine Dental Ointment

Xylocaine Endotracheal

Xylocaine Test Dose

Xylocaine Viscous

Xylocaine-Mpf

Xylocaine-Mpf with Glucose

Xylocard

Xylocitin

Xyloneural

Xyloneural (free base)

Xylotox

Zilactin-L

Zingo

α-diethylamino-2,6-dimethylacetanilide

Triazolam

Approved, Investigational

Phase 4

28911-01-5

5556

Synonyms:

28911-01-5

8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine

8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine

8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

AC1L1KLZ

Alti-Triazolam

apo Triazo

Apo Triazo

Apotex brand OF triazolam

Apotex Brand of Triazolam

apo-Triazo

Apo-Triazo

BRN 1226643

C17H12Cl2N4

CCRIS 1932

CHEBI:9674

CHEMBL646

CID5556

Clorazolam

D00387

D014229

DB00897

DEA no. 2887

DEA No. 2887

EINECS 249-307-3

Gen triazolam

Gen Triazolam

Genpharm brand OF triazolam

Genpharm Brand of Triazolam

Gen-triazolam

Gen-Triazolam

Gerard brand OF triazolam

Gerard Brand of Triazolam

Halcion

Halcion (TN)

Halcion (triazolam)

HSDB 6759

Hypnostat

L000796

LS-156323

MolPort-003-959-834

NCGC00168258-01

nchembio747-comp15

Novidorm

Novodorm

Novo-Triolam

Pfizer brand OF triazolam

Pfizer Brand of Triazolam

Songar

T9772_SIGMA

TGAR01H

triazolam

Triazolam

Triazolam (JAN/USP/INN)

Triazolam [USAN:BAN:INN:JAN]

Triazolam pfizer brand

Triazolam Pfizer Brand

Triazolamum

Triazolamum [INN-Latin]

Trilam

U 33,030

U 33030

U33,030

U-33,030

U-33030

UNII-1HM943223R

ZINC00002212

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Synonyms:

( inverted exclamation markA)-bupivacaine

(+-)-Bupivacaine

(±)-bupivacaine

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(RS)-bupivacaine

15233-43-9

1-Butyl-2',6'-pipecoloxylidide

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

2180-92-9

38396-39-3

AB00053674

Abbott brand OF bupivacaine hydrochloride

AC1L1DRE

AC1Q5LX4

AC-2096

AH 250

AKOS001637202

Anekain

Anhydrous, bupivacaine

AR-1A0242

Astra brand OF bupivacaine hydrochloride

AstraZeneca brand OF bupivacaine hydrochloride

Aventis brand OF bupivacaine hydrochloride

Bio-0886

Bloqueina

BPBio1_000298

Braun brand OF bupivacaine hydrochloride

Braun, bupivacaina

BRD-A01636364-003-05-2

BSPBio_000270

BSPBio_002607

Bucaine

Bucaine (TN)

Bupivacain janapharm

Bupivacain RPR

Bupivacaina

Bupivacaina [INN-Spanish]

Bupivacaina braun

bupivacaine

Bupivacaine

Bupivacaine (INN)

Bupivacaine [INN:BAN]

Bupivacaine anhydrous

Bupivacaine carbonate

Bupivacaine Carbonate

Bupivacaine HCL

Bupivacaine HCL kit

Bupivacaine HCL KIT

Bupivacaine hydrochloride

Bupivacaine monohydrochloride, monohydrate

Bupivacaine Monohydrochloride, Monohydrate

Bupivacain-RPR

Bupivacainum

Bupivacainum [INN-Latin]

Bupivan

Buvacaina

C07529

C18H28N2O

Carbonate, bupivacaine

Carbostesin

cBupivacaine

CBupivacaine

CHEBI:3215

CHEMBL1098

CID2474

D07552

DB00297

DepoBupivacaine

DivK1c_000758

dl-1-Butyl-2',6'-pipecoloxylidide

DL-Bupivacaine

Dolanaest

DUR-843

EINECS 218-553-3

EINECS 253-911-2

HMS2090F12

Hydrochloride, bupivacaine

IDI1_000758

Inibsa brand OF bupivacaine hydrochloride

Janapharm, bupivacain

Jenapharm brand OF bupivacaine hydrochloride

KBio1_000758

KBio2_002004

KBio2_004572

KBio2_007140

KBio3_001827

KBioGR_001516

KBioSS_002004

KST-1A4609

L000695

LAC-43

LS-109841

LS-2222

Marcain

Marcaina

Marcaine

Marcaine HCL

Marcaine Spinal

MLS001361336

MolPort-004-955-820

NCGC00178579-01

NCGC00178579-02

NINDS_000758

NSC119660

Pisa brand OF bupivacaine hydrochloride

Prestwick0_000305

Prestwick1_000305

Prestwick2_000305

Prestwick3_000305

Racemic bupivacaine

Sensorcaine

Sensorcaine-MPF

Sensorcaine-MPF Spinal

SMR000058218

SPBio_001558

SPBio_002489

Spectrum_001524

Spectrum2_001589

Spectrum3_000974

Spectrum4_001098

Spectrum5_001483

Strathmann brand OF bupivacaine hydrochloride

Svedocain sin vasoconstr

Transdur-Bupivacaine

UNII-Y8335394RO

Win 11318

Win 11318 HCl

Proxymetacaine

Phase 4

Anesthetics

Phase 4

Hypnotics and Sedatives

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block	Not yet recruiting	NCT04346095	Phase 4	Oral Sedatives with or Without Analgesia;Intravenous Sedatives with or Without Analgesia
2	Cionni Ring and In-the-bag IOL Implantation for Subluxated Lenses: A Prospective Case Series	Completed	NCT01346566	Phase 3
3	Biometric Indicators of Eyes With Occult Lens Subluxation	Completed	NCT03752710
4	Ultrasound Biomicroscopic Analysis of Cionni Ring and In-the-bag IOL Implantation for Subluxated Lenses	Completed	NCT02790268
5	Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery	Recruiting	NCT04120389
6	Late In-the-bag intraOcular Lens dislocatioN Surgery: A Randomized Clinical Trial (LION Trial)	Recruiting	NCT03276104
7	Anterior Segment Changes Before and After Uneventful Combined Phaco-Trabeculectomy by Using Optical Coherence Tomography (OCT)	Recruiting	NCT03626675
8	Study of Multifunctional Cataract-assisted Retractor in Complicated Cataract Surgery	Active, not recruiting	NCT04062084
9	Late Dislocation of Intraocular Lens (IOL) Following Cataract Surgery: an Evaluation of Two Different Surgical Methods	Active, not recruiting	NCT01784926

Search NIH Clinical Center for Lens Subluxation

Sources

Genetic Tests for Lens Subluxation

Genetic tests related to Lens Subluxation:

#	Genetic test	Affiliating Genes
1	Lens Subluxation ²⁹

Sources

Anatomical Context for Lens Subluxation

MalaCards organs/tissues related to Lens Subluxation:

⁴⁰

Eye, Bone, Testes, Endothelial

Sources

Publications for Lens Subluxation

Articles related to Lens Subluxation:

(show top 50) (show all 329)

#	Title	Authors	PMID	Year
1	Asymmetric pigmentary glaucoma in a patient with Marfan's syndrome. ⁵⁴ ⁶¹	Doyle A...Lachkar Y	15834601	2005
2	Determination of the molecular basis of Marfan syndrome: a growth industry. ⁵⁴ ⁶¹	Byers PH	15254580	2004
3	Pharmacologic pupillary constriction after dilated fundus examination for ectopia lentis to prevent further subluxation. ⁶¹	Plum W...Woreta FA	32300672	2020
4	Cataract extraction in patients with primary congenital glaucoma. ⁶¹	Morales-Fernandez L...Garcia-Feijoo J	30957520	2020
5	Trans-scleral plugs fixated IOL: a new paradigm for sutureless scleral fixation. ⁶¹	Barca F...Rizzo S	32358266	2020
6	Evaluation of vitreous degeneration as a potential risk factor for retinal detachment after phacoemulsification in dogs. ⁶¹	West MC...Rose MD	32472635	2020
7	New surgical approach for sutureless scleral fixation. ⁶¹	Veronese C...Ciardella AP	32000520	2020
8	The prevalence of uveitis in a population of donkeys in the UK. ⁶¹	Bradley C...Sansom PG	32145036	2020
9	[Scleral-fixated intraocular lenses with Z‑suture technique for lens subluxation associated with spherophakia]. ⁶¹	Bocque C...Januschowski K	31222453	2020
10	Biometric indicators of eyes with occult lens subluxation inducing secondary acute angle closure. ⁶¹	Xing X...Liu A	32138781	2020
11	Retinal break associated with traumatic lens dislocation or subluxation requiring vitrectomy. ⁶¹	Ke G...Gu Y	31781882	2020
12	Epidemiology of Eye Injuries Resulting in Hospitalization, a Referral Hospital-Based Study. ⁶¹	Choovuthayakorn J...Tananuvat N	32021063	2020
13	"Sutureless scleral fixation using Carlevale lens: surgical and refractive outcomes". ⁶¹	Barca F...Rizzo S	32347697	2020
14	Doubles trouble-85 cases of ocular trauma in badminton: clinical features and prevention. ⁶¹	Yu J...Liu Y	30988018	2020
15	Evaluation of functional outcome and stability of sutureless scleral tunnel fixated IOLs in children with ectopia lentis. ⁶¹	Rastogi A...Bhardwaj A	31956572	2020
16	Double-Flanged polypropylene Suture for Scleral Fixation of Cionni Capsule Tension Ring. ⁶¹	Samir A...Lotfy A	32368003	2020
17	Femtosecond laser-assisted cataract surgery in a spherophakic lens: An unusual case report. ⁶¹	Cao D...Wang L	31689746	2019
18	Eye injury and demographic parameters associated with poor visual outcome. ⁶¹	Jovanovic N...Musa S	31122763	2019
19	Intraoperative and postoperative complications of cataract surgery in eyes with pseudoexfoliation - An 8-year analysis. ⁶¹	Thevi T...Abas AL	31902990	2019
20	[Bilateral posterior lens subluxation in the context of physical abuse: Case report]. ⁶¹	Fossum P...Deltour JB	31130383	2019
21	Irreversible Ocular Lesions in a Dog With Angiostrongylus Vasorum Infection. ⁶¹	Ciuca L...Lamagna B	31472726	2019
22	Is specialized ophthalmologic evaluation necessary after orbital fractures? A prospective 64-case study. ⁶¹	Marano R...Oliveira L	31104221	2019
23	Neglected Congenital Glaucoma With Lens Coloboma. ⁶¹	Dhingra D...Kaushik S	31135584	2019
24	[Application of femtosecond laser technology in the management of subluxated lens]. ⁶¹	Ju R...Wu Z	31340919	2019
25	Self-induced lens subluxation with avulsion of ciliary processes in Tourette Syndrome. ⁶¹	Francisconi CLM...Kertes PJ	31008412	2019
26	Bilateral lens subluxation in Marfan syndrome. ⁶¹	Gupta G...Jinagal J	30517757	2019
27	Cataract surgery outcomes in eyes with chorioretinal coloboma. ⁶¹	Sahay P...Titiyal JS	31030778	2019
28	WAGRO syndrome: a rare genetic condition associated with aniridia and additional ophthalmologic abnormalities. ⁶¹	Ferreira MAT...Zen PRG	31116317	2019
29	Tadeusz Krwawicz, MD: The inventor of cryosurgery in ophthalmology. ⁶¹	Grzybowski A...Kanclerz P	30638059	2019
30	Clinical Features and Efficacy of Lens Surgery in Patients with Lens Subluxation Misdiagnosed as Primary Angle-Closure Glaucoma. ⁶¹	Zhang Y...Zhu X	30426797	2019
31	Epidemiology and clinical presentation of feline cataracts in france: A retrospective study of 268 cases. ⁶¹	Guyonnet A...Chahory S	29508528	2019
32	Bilateral Phacoemulsification in an African Elephant (Loxodonta africana). ⁶¹	Cerreta AJ...Minter LJ	31380140	2019
33	Characteristic Manifestations regarding Ultrasound Biomicroscopy Morphological Data in the Diagnosis of Acute Angle Closure Secondary to Lens Subluxation. ⁶¹	Wang F...Wang L	31341905	2019
34	Two Paired Box 6 mutations identified in Chinese patients with classic congenital aniridia and cataract. ⁶¹	Lin Y...Lu L	30221735	2018
35	Zika and the Eye: Pieces of a Puzzle. ⁶¹	de Oliveira Dias JR...Zika Virus Study Group	29698814	2018
36	BLINDNESS RELATED TO PRESUMED RETINAL TOXICITY AFTER USING PERFLUOROCARBON LIQUID DURING VITREORETINAL SURGERY. ⁶¹	Mendez-Martinez S...Pablo L	28723847	2018
37	Statin use and vitreoretinal surgery: Findings from a Finnish population-based cohort study. ⁶¹	Loukovaara S...Haukka J	29338115	2018
38	Rabbits with naturally occurring cataracts referred for phacoemulsification and intraocular lens implantation: a preliminary study of 12 cases. ⁶¹	Sanchez RF...Seymour C	29205744	2018
39	A Case of a Ruptured Eyeball Caused by High-Pressure Water Jets. ⁶¹	Oosuka S...Ikeda T	29927474	2018
40	Bilateral Crystalline Lens Subluxation in a Child With Marfan Syndrome. ⁶¹	Weng CY...Al-Mohtaseb Z	29902318	2018
41	Outcomes of lensectomy and risk factors for failure in spherophakic eyes with secondary glaucoma. ⁶¹	Rao DP...Senthil S	28928265	2018
42	[A preliminary observation of implanting a double-eyelet capsular tension ring in eyes with serious lens subluxation]. ⁶¹	Zhang B...Zheng DY	29747365	2018
43	Advanced Midzonal Iris Pigment Epithelial Cyst Managed by Aspiration Deflation. ⁶¹	Shields JA...Shields CL	29765951	2018
44	Corneal Curvature, Astigmatism, and Aberrations in Marfan Syndrome with Lens Subluxation: Evaluation by Pentacam HR System. ⁶¹	Chen J...Jiang Y	29511238	2018
45	A survey of ocular ultrasound abnormalities in horse: 145 cases. ⁶¹	Gialletti R...Laus F	29492841	2018
46	Comparative evaluation of rotational stability and visual outcome of toric intraocular lenses with and without a capsular tension ring. ⁶¹	Rastogi A...Kumar P	29480253	2018
47	Rhegmatogenous retinal detachment in paediatric patients after pars plana vitrectomy and sutured scleral-fixated intraocular lenses. ⁶¹	Sen P...Sreelakshmi K	28862256	2018
48	Surgical outcomes and complications of sutured scleral fixated intraocular lenses in pediatric eyes. ⁶¹	Sen P...Gopal L	29426441	2018
49	[Surgical technique of retropupillary iris-claw fixated IOL reimplantation]. ⁶¹	Yusef YN...Alkhumidi K	29953088	2018
50	Role of 25 MHz Ultrasound Biomicroscopy in the Detection of Subluxated Lenses. ⁶¹	Shi M...Yan Q	30416825	2018

Sources

Genes for Lens Subluxation

Genes related to Lens Subluxation (2 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	FBN1	Fibrillin 1	Protein Coding	429.12	Pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	15834601 15254580
2	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	407.3	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
3	P3H2	Prolyl 3-Hydroxylase 2	Protein Coding	20.6	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
4	VSX2	Visual System Homeobox 2	Protein Coding	12.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	11.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	PEX19	Peroxisomal Biogenesis Factor 19	Protein Coding	6.83	DISEASES inferred ¹⁵
7	CRYAA	Crystallin Alpha A	Protein Coding	6.81	DISEASES inferred ¹⁵ ¹⁵
8	CBS	Cystathionine Beta-Synthase	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
9	GALT	Galactose-1-Phosphate Uridylyltransferase	Protein Coding	6.7	GeneCards inferred via : Publications (show sections)
10	LOXL1	Lysyl Oxidase Like 1	Protein Coding	6.66	DISEASES inferred ¹⁵
11	ADAMTS10	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10	Protein Coding	6.59	DISEASES inferred ¹⁵
12	ADAMTS17	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17	Protein Coding	6.41	DISEASES inferred ¹⁵
13	PAX6	Paired Box 6	Protein Coding	6.23	DISEASES inferred ¹⁵
14	MPDU1	Mannose-P-Dolichol Utilization Defect 1	Protein Coding	6.04	DISEASES inferred ¹⁵
15	ADAMTSL4	ADAMTS Like 4	Protein Coding	6.01	DISEASES inferred ¹⁵
16	IQCK	IQ Motif Containing K	Protein Coding	5.94	DISEASES inferred ¹⁵
17	BFSP1	Beaded Filament Structural Protein 1	Protein Coding	5.9	DISEASES inferred ¹⁵
18	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	5.77	DISEASES inferred ¹⁵
19	LAMA3	Laminin Subunit Alpha 3	Protein Coding	5.7	DISEASES inferred ¹⁵
20	CRYBA2	Crystallin Beta A2	Protein Coding	5.64	DISEASES inferred ¹⁵
21	CRYBA4	Crystallin Beta A4	Protein Coding	5.64	DISEASES inferred ¹⁵
22	SUOX	Sulfite Oxidase	Protein Coding	5.61	DISEASES inferred ¹⁵

Sources

Variations for Lens Subluxation

ClinVar genetic disease variations for Lens Subluxation:

⁶ ‎‎ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	TFAP2A	NM_001032280.3(TFAP2A):c.1019_1020del (p.Lys340fs)	deletion	Pathogenic	523459	rs1554110735	6:10398926-10398927	6:10398693-10398694
2	FBN1	NM_000138.4(FBN1):c.364C>T (p.Arg122Cys)	SNV	Pathogenic	16440	rs137854467	15:48892414-48892414	15:48600217-48600217
3	FBN1	NM_000138.4(FBN1):c.1481G>T (p.Cys494Phe)	SNV	Likely pathogenic	374079	rs1057518881	15:48805853-48805853	15:48513656-48513656

Sources

Expression for Lens Subluxation

Search GEO for disease gene expression data for Lens Subluxation.

Sources

Pathways for Lens Subluxation

Pathways related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.01	P3H2 LTBP2 LOXL1 LAMA3 FBN1
2	O-glycosylation of TSR domain-containing proteins ⁶⁵ Show member pathways Defective B3GALTL causes Peters-plus syndrome (PpS) ⁶⁵	11.31	ADAMTSL4 ADAMTS17 ADAMTS10
3	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	11.2	LTBP2 LOXL1 FBN1
4	Folate-Alcohol and Cancer Pathway ¹	9.53	MTHFR CBS

Sources

GO Terms for Lens Subluxation

Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	basement membrane	GO:0005604	9.46	P3H2 LOXL1 LAMA3 FBN1
2	collagen-containing extracellular matrix	GO:0062023	9.43	LTBP2 LOXL1 LAMA3 FBN1 ADAMTSL4 ADAMTS10
3	microfibril	GO:0001527	9.26	FBN1 ADAMTS10
4	extracellular matrix	GO:0031012	9.1	LTBP2 LOXL1 FBN1 ADAMTSL4 ADAMTS17 ADAMTS10

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:0007601	9.46	VSX2 PAX6 CRYBA2 CRYAA
2	extracellular matrix organization	GO:0030198	9.1	LOXL1 LAMA3 FBN1 ADAMTSL4 ADAMTS17 ADAMTS10
3	homocysteine metabolic process	GO:0050667	8.96	MTHFR CBS

Molecular functions related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	9.43	LTBP2 LAMA3 FBN1
2	metalloendopeptidase activity	GO:0004222	9.33	ADAMTSL4 ADAMTS17 ADAMTS10
3	modified amino acid binding	GO:0072341	8.96	MTHFR CBS
4	structural constituent of eye lens	GO:0005212	8.8	CRYBA2 CRYAA BFSP1

Sources

Sources for Lens Subluxation

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia