Lens Subluxation disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNS001 MIFTS: 40	Lens Subluxation Categories: Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Lens Subluxation

MalaCards integrated aliases for Lens Subluxation:

Name: Lens Subluxation ¹² ²⁹ ⁵⁴ ⁶ ⁴⁴ ¹⁵ ⁷⁰

Subluxation of Lens ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11364

ICD9CM ³⁴ 379.32

MeSH ⁴⁴ D007906

NCIt ⁵⁰ C34772

SNOMED-CT ⁶⁷ 155203002

ICD10 ³² H27.11

UMLS ⁷⁰ C0023316

Sources

Summaries for Lens Subluxation

MalaCards based summary : Lens Subluxation, also known as subluxation of lens, is related to isolated ectopia lentis and marfan syndrome. An important gene associated with Lens Subluxation is FBN1 (Fibrillin 1), and among its related pathways/superpathways are O-linked glycosylation and Diseases of glycosylation. The drugs Fentanyl and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are integument and pigmentation

Wikipedia : ⁷³ Ectopia lentis is a displacement or malposition of the eye's crystalline lens from its normal location.... more...

Sources

Related Diseases for Lens Subluxation

Diseases related to Lens Subluxation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)

#	Related Disease	Score	Top Affiliating Genes
1	isolated ectopia lentis	31.3	LTBP2 FBN1 CBS ADAMTSL4 ADAMTSL2 ADAMTS17
2	marfan syndrome	30.6	MTHFR LTBP2 LOXL1 FBN1 CBS
3	intraocular pressure quantitative trait locus	30.5	PAX6 LTBP2 LOXL1 FBN1 CRYAA
4	retinal detachment	30.3	PAX6 P3H2 ADAMTSL4
5	homocysteinemia	30.2	MTHFR FBN1 CBS
6	homocystinuria	30.2	MTHFR FBN1 CBSL CBS
7	megalocornea	30.1	LTBP2 FBN1 ADAMTS17 ADAMTS10
8	amblyopia	29.9	TFAP2A PAX6 CRYAA BFSP1
9	coloboma of macula	29.8	VSX2 TFAP2A PAX6 CRYBA4 CRYAA
10	open-angle glaucoma	29.7	MTHFR LTBP2 LOXL1 FBN1 CRYAA
11	microphthalmia	29.6	VSX2 TFAP2A PAX6 CRYBA4 CRYAA
12	myopia	29.5	PAX6 P3H2 LTBP2 FBN1 CRYBA4 CRYAA
13	primary congenital glaucoma	29.5	PAX6 LTBP2 LOXL1 FBN1 CRYAA ADAMTS10
14	aniridia 1	29.2	VSX2 PAX6 LTBP2 CRYBA4 CRYAA BFSP1
15	cataract	28.9	VSX2 PAX6 P3H2 MTHFR LOXL1 GALT
16	myopia, high, with cataract and vitreoretinal degeneration	11.1
17	late-onset localized junctional epidermolysis bullosa-intellectual disability syndrome	11.1
18	exencephaly	10.3	TFAP2A MTHFR
19	coloboma of iris	10.3	TFAP2A PAX6
20	lens position anomaly	10.3	FBN1 ADAMTSL4
21	microphthalmia, syndromic 8	10.3	VSX2 PAX6
22	fryns microphthalmia syndrome	10.3	VSX2 PAX6
23	morgagni cataract	10.3	LOXL1 CRYAA
24	leukocoria	10.3	VSX2 CRYAA
25	branch retinal artery occlusion	10.3	MTHFR CRYAA
26	microphthalmia, isolated 3	10.3	VSX2 PAX6
27	central retinal artery occlusion	10.3	MTHFR CRYAA
28	microphthalmia, isolated 2	10.2	VSX2 PAX6
29	isolated microspherophakia	10.2	LTBP2 ADAMTS10
30	traumatic glaucoma	10.2	LTBP2 LOXL1
31	retinal vascular occlusion	10.2	MTHFR LOXL1 CRYAA
32	congenital aphakia	10.2	VSX2 PAX6 CRYAA
33	exotropia	10.2	PAX6 FBN1 CRYAA
34	anisometropia	10.2	PAX6 CRYAA
35	esotropia	10.2	TFAP2A PAX6 CRYAA
36	cataract 24	10.2	CRYBA2 CRYAA
37	microphthalmia, isolated 1	10.2	VSX2 CRYBA4
38	cutis laxa, autosomal recessive, type ia	10.2	LOXL1 FBN1
39	stickler syndrome	10.2	LOXL1 FBN1 CRYAA
40	orbital disease	10.2	FBN1 CRYAA
41	galactosemia ii	10.2	GALT CRYAA BFSP1
42	nanophthalmos	10.2	VSX2 PAX6 LOXL1
43	cataract 48	10.2	CRYBA2 CRYAA
44	early-onset lamellar cataract	10.2	CRYBA4 CRYAA
45	keratitis, hereditary	10.2	VSX2 PAX6 CRYAA
46	presbyopia	10.2	CRYAA BFSP1
47	uveal disease	10.2	PAX6 LOXL1 CRYAA
48	corneal edema	10.1
49	primary angle-closure glaucoma	10.1
50	dermatitis	10.1

Graphical network of the top 20 diseases related to Lens Subluxation:

Sources

Symptoms & Phenotypes for Lens Subluxation

MGI Mouse Phenotypes related to Lens Subluxation:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.91	ADAMTS10 ADAMTS17 ADAMTSL4 CBSL FBN1 LOXL1
2	pigmentation	MP:0001186	9.55	ADAMTSL4 FBN1 PAX6 TFAP2A VSX2
3	respiratory system	MP:0005388	9.5	ADAMTSL2 CBSL FBN1 LOXL1 LTBP2 PAX6
4	vision/eye	MP:0005391	9.4	ADAMTS10 ADAMTSL4 BFSP1 CBSL CRYBA2 LOXL1

Sources

Drugs & Therapeutics for Lens Subluxation

Drugs for Lens Subluxation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Synonyms:

1-Phenethyl-4-(N-phenylpropionamido)piperidine

1-phenethyl-4-N-propionylanilinopiperidine

1-Phenethyl-4-N-propionylanilinopiperidine

437-38-7

5-22-08-00049 (Beilstein Handbook Reference)

80832-90-2

990-73-8 (citrate)

AC1L1FQ2

Actiq

BIDD:GT0555

BRN 0494484

Cephalon brand OF fentanyl buccal oravescent

CHEBI:119915

CHEMBL596

CID3345

D00320

DB00813

Duragesic

Duragesic (TN)

Duragesic-100

Duragesic-12

Duragesic-25

Duragesic-50

Duragesic-75

Durogesic

EINECS 207-113-6

Fentanest

Fentanil

Fentanil [DCIT]

Fentanila

Fentanila [INN-Spanish]

Fentanilo

fentanyl

Fentanyl

Fentanyl (JAN/USAN/INN)

Fentanyl [INN:BAN]

Fentanyl CII

Fentanyl citrate

Fentanyl-100

Fentanyl-12

Fentanyl-25

Fentanyl-50

Fentanyl-75

Fentanylum

Fentanylum [INN-Latin]

Fentora

HSDB 3329

IONSYS

Janssen pharmaceutica brand OF fentanyl

JNS020QD

L001275

LS-124439

Matrifen

MolPort-003-847-369

N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide

N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide

N-(1-phenethyl-4-piperidyl)propionanilide

N-(1-Phenethyl-4-piperidyl)propionanilide

N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide

N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide

N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide

N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide

Nasalfent

NCGC00168252-01

N-phenethyl-4-(N-propionylanilino)piperidine

N-Phenethyl-4-(N-propionylanilino)piperidine

N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide

N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide

N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

Oprea1_152073

Oprea1_207148

PDSP1_000860

PDSP2_000846

Pentanyl

Phentanyl

Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)

R 4263

Rapinyl

Sentonil

Sublimase

Sublimaze

Subsys

Transmucosal oral fentanyl citrate

UNII-UF599785JZ

Midazolam

Approved, Illicit

Phase 4

59467-70-8

4192

Synonyms:

4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate

59467-70-8

8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine

8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride

8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine

8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine

AC-18749

AC1L1HMA

BIDD:GT0647

BRN 0625572

Buccolam

C07524

C18H13ClFN3

CHEMBL655

CID4192

D00550

Dazolam

DB00683

Dea no. 2884

Dea No. 2884

DEA No. 2884

Dormicum

Dormicum (TN)

EINECS 261-774-5

Hydrochloride, midazolam

LS-77780

Maleate, midazolam

Mezolam

Midanium

midazolam

Midazolam

Midazolam (JAN/INN)

Midazolam [INN:BAN:JAN]

Midazolam base

Midazolam Base

Midazolam Hcl

Midazolam hydrochloride

Midazolam maleate

Midazolamum

Midazolamum [INN-Latin]

Midosed

MolPort-003-849-219

NCGC00168254-01

nchembio747-comp32

Ro 21-3981

TL8003787

UC429_SIGMA

UNII-R60L0SM5BC

Versed

ZINC00001732

Triazolam

Approved, Investigational

Phase 4

28911-01-5

5556

Synonyms:

28911-01-5

8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine

8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine

8-Chloro-6-(o-chlorophenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

8-Chloro-6-[2-chlorophenyl]-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

AC1L1KLZ

Alti-Triazolam

Apo triazo

Apo Triazo

Apotex brand OF triazolam

Apotex Brand of Triazolam

Apo-triazo

Apo-Triazo

BRN 1226643

C17H12Cl2N4

CCRIS 1932

CHEBI:9674

CHEMBL646

CID5556

Clorazolam

D00387

D014229

DB00897

DEA no. 2887

DEA No. 2887

EINECS 249-307-3

Gen triazolam

Gen Triazolam

Genpharm brand OF triazolam

Genpharm Brand of Triazolam

Gen-triazolam

Gen-Triazolam

Gerard brand OF triazolam

Gerard Brand of Triazolam

Halcion

Halcion (TN)

Halcion (triazolam)

HSDB 6759

Hypnostat

L000796

LS-156323

MolPort-003-959-834

NCGC00168258-01

nchembio747-comp15

Novidorm

Novodorm

Novo-Triolam

Pfizer brand OF triazolam

Pfizer Brand of Triazolam

Songar

T9772_SIGMA

TGAR01H

triazolam

Triazolam

Triazolam (JAN/USP/INN)

Triazolam [USAN:BAN:INN:JAN]

Triazolam pfizer brand

Triazolam Pfizer Brand

Triazolamum

Triazolamum [INN-Latin]

Trilam

U 33,030

U 33030

U33,030

U-33,030

U-33030

UNII-1HM943223R

ZINC00002212

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Synonyms:

.alpha.-(Diethylamino)-2,6-acetoxylidide

.alpha.-Diethylamino-2,6-dimethylacetanilide

.alpha.-Diethylaminoaceto-2,6-xylidide

.omega.-Diethylamino-2,6-dimethylacetanilide

137-58-6

2-(Diethylamino)-2',6'-acetoxylidide

2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

2-2ETN-2MePhAcN

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide

2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide

4-12-00-02538 (Beilstein Handbook Reference)

6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))

6108-05-0 (mono-hydrochloride, mono-hydrate)

73-78-9 (mono-hydrochloride)

AB00053581

AC-10282

AC1L1GGQ

AC1Q2Z7J

a-Diethylamino-2,6-dimethylacetanilide

After Burn Double Strength Gel

After Burn Double Strength Spray

After Burn Gel

After Burn Spray

AKOS001026768

alfa-Dietilamino-2,6-dimetilacetanilide

alfa-Dietilamino-2,6-dimetilacetanilide [Italian]

Alphacaine

alpha-diethylamino-2,6-dimethylacetanilide

alpha-Diethylamino-2,6-dimethylacetanilide

Anestacon

Anestacon Jelly

ARONIS23855

Astrazeneca brand OF lidocaine

BIDD:GT0342

Bio-0767

Bio1_000379

Bio1_000868

Bio1_001357

Bio2_000079

Bio2_000559

BPBio1_000197

BRD-K52662033-001-02-6

BRD-K52662033-003-05-5

BRN 2215784

BSPBio_000179

BSPBio_001359

BSPBio_003004

C07073

C14H22N2O

Cappicaine

CAS-73-78-9

CDS1_000283

CHEBI:6456

CHEMBL79

CID3676

Cito optadren

CPD000058189

Cuivasil

D00358

Dalcaine

DB00281

Dentipatch

Dentipatch (TN)

DermaFlex

Diethylaminoaceto-2,6-xylidide

Dilocaine

DivK1c_000174

DivK1c_001323

Duncaine

EINECS 205-302-8

ELA-Max

EMBOLEX

Emla Cream

Esracaine

FT-0082378

Gravocain

HMS1791D21

HMS1989D21

HMS2051C21

HMS2089E15

HMS548M19

HSDB 3350

I01-2704

IDI1_000174

IDI1_033829

Isicaina

Isicaine

Jenapharm brand OF lidocanine hydrochloride

Jetocaine

KBio1_000174

KBio2_000079

KBio2_001598

KBio2_002647

KBio2_004166

KBio2_005215

KBio2_006734

KBio3_000157

KBio3_000158

KBio3_002224

KBioGR_000079

KBioGR_000599

KBioSS_000079

KBioSS_001598

L0156

L1026_SIGMA

L7757_SIGMA

Lanabiotic

L-Caine

Leostesin

Lida-Mantle

Lidocaina

Lidocaína

Lidocaina [INN-Spanish]

lidocaine

Lidocaine

LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)

Lidocaine (JP15/USP/INN)

Lidocaine (VAN)

Lidocaine [USAN:INN:JAN]

Lidocaine carbonate

Lidocaine Carbonate

Lidocaine carbonate (2:1)

Lidocaine hydrocarbonate

Lidocaine Hydrocarbonate

Lidocaine hydrochloride

Lidocaine monoacetate

Lidocaine monohydrochloride

Lidocaine Monohydrochloride

Lidocaine monohydrochloride, monohydrate

Lidocaine sulfate (1:1)

Lidocainum

Lidocainum [INN-Latin]

Lidocaton

Lidoderm

Lidoject-1

Lidoject-2

LIDOPEN

Lignocaine

Lignocainum

Lingocaine

Lopac0_000669

Lopac-L-5647

LQZ

LS-805

Maricaine

Maybridge1_002571

MLS000069724

MLS000758263

MLS001074177

MolPort-001-783-478

N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide

N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide

NCGC00015611-01

NCGC00015611-02

NCGC00015611-03

NCGC00015611-04

NCGC00015611-14

NCGC00022176-05

NCGC00022176-06

NCGC00022176-07

NCGC00022176-08

NCGC00022176-09

nchembio.65-comp16

NINDS_000174

Norwood Sunburn Spray

Novocol brand OF lidocaine hydrochloride

NSC 40030

NSC40030

Octocaine

Octocaine-100

Octocaine-50

Prestwick0_000050

Prestwick1_000050

Prestwick2_000050

Prestwick3_000050

Remicaine

Rocephin Kit

Rucaina

S1357_Selleck

SAM001247018

SMR000058189

Solarcaine aloe extra burn relief cream

Solcain

SPBio_001525

SPBio_002100

Spectrum_001118

Spectrum2_001343

Spectrum3_001392

Spectrum4_000070

Spectrum5_001549

STK552033

Strathmann brand OF lidocaine hydrochloride

UNII-98PI200987

WLN: 2N2 & 1VMR B1 F1

Xilina

Xilocaina

Xilocaina [Italian]

Xllina

Xycaine

Xylestesin

Xylesthesin

Xylocain

Xylocaine

Xylocaine (TN)

Xylocaine 5% Spinal

Xylocaine CO2

Xylocaine Dental Ointment

Xylocaine Endotracheal

Xylocaine Test Dose

Xylocaine Viscous

Xylocaine-Mpf

Xylocaine-Mpf with Glucose

Xylocard

Xylocitin

Xyloneural

Xyloneural (free base)

Xylotox

Zilactin-L

Zingo

α-diethylamino-2,6-dimethylacetanilide

Α-diethylamino-2,6-dimethylacetanilide

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Synonyms:

2, 6-Diisopropylphenol

2,6 Diisopropylphenol

2,6-bis(1-methylethyl)phenol

2,6-bis(1-methylethyl)-phenol

2,6-Bis(1-methylethyl)phenol

2,6-Bis(Isopropyl)-phenol

2,6-di(propan-2-yl)phenol

2,6-Diisopropyl phenol

2,6-Diisopropylphenol

2,6-DIISOPROPYLPHENOL

2078-54-8

28449-97-0

4-06-00-03435 (Beilstein Handbook Reference)

50356-15-5

AB00513968

Abbott brand OF propofol

Abbott Brand of Propofol

AC1L1J9Y

AC1Q1OUI

AC-2038

AI3-26295

Alpha Brand of Propofol

Alpha Brand OF propofol

AM-149

Ampofol

Aquafol

Astra brand OF propofol

Astra Brand of Propofol

AstraZeneca brand OF propofol

AstraZeneca Brand of Propofol

BIDD:GT0436

Biomol-NT_000248

BPBio1_000950

BPBio1_000969

Braun brand OF propofol

Braun Brand of Propofol

BRD-K82255054-001-03-5

BRN 1866484

BSPBio_000862

C07523

C12H18O

CAS-2078-54-8

CCRIS 9000

CHEBI:44915

CHEMBL526

CID4943

CPD000059151

CPD-11437

Curamed brand OF propofol

Curamed Brand of Propofol

D00549

D015742

D0617

D126608

D126608_ALDRICH

DB00818

DDS-04F

Diisopropylphenol

Dipravan

Diprivan

Diprivan (TN)

Diprivan Injectable emulsion

Disoprivan

Disoprofol

EINECS 218-206-6

EU-0100437

Fresenius brand OF propofol

Fresenius Brand of Propofol

Fresenius kabi brand OF propofol

Fresenius Kabi Brand of Propofol

Fresofol

ghl.PD_Mitscher_leg0.558

HMS1570L04

HMS2089O21

HMS2094E17

HSDB 7123

ICI 35,868

ICI 35868

ICI35,868

ICI-35,868

ICI35868

ICI-35868

InChI=1/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H

Ivofol

Jsp004266

Juste brand OF propofol

Juste Brand of Propofol

Lopac0_000437

Lopac-D126608

LS-996

MLS001066348

MLS001335999

MLS002454360

MolPort-001-794-517

NCGC00015389-01

NCGC00015389-02

NCGC00015389-04

NCGC00015389-09

NCGC00091538-01

NCGC00091538-02

NCGC00091538-03

NCGC00091538-04

NCGC00091538-05

NCGC00091538-06

nchembio.552-comp7

NSC 5105

NSC5105

Parnell brand OF propofol

Parnell Brand of Propofol

PFL

Pisa brand OF propofol

Pisa Brand of Propofol

Prestwick0_000931

Prestwick1_000931

Prestwick2_000931

Prestwick3_000931

propofol

Propofol

Propofol (JAN/USAN/INN)

Propofol [USAN:INN:BAN]

Propofol abbott

Propofol Abbott

Propofol fresenius

Propofol Fresenius

Propofol IDD-D

Propofol MCT

Propofol rovi

Propofol Rovi

Propofol(2,6-Diisopropylphenol)

Propofol-lipuro

Propofol-Lipuro

Propofolum

Propofolum [Latin]

Rapinovet

Recofol

Rovi brand OF propofol

Rovi Brand of Propofol

S01-0189

SAM002264610

Schering brand OF propofol

Schering Brand of Propofol

SMR000059151

SPBio_003031

SPECTRUM1505022

ST50405911

UNII-YI7VU623SF

W505102_ALDRICH

ZD-0859

Zeneca brand OF propofol

Zeneca Brand of Propofol

ZINC00968303

Bupivacaine

Approved, Investigational

Phase 4

38396-39-3, 2180-92-9

2474

Synonyms:

( inverted exclamation markA)-bupivacaine

(+-)-Bupivacaine

(±)-bupivacaine

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(RS)-bupivacaine

15233-43-9

1-Butyl-2',6'-pipecoloxylidide

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

2180-92-9

38396-39-3

AB00053674

Abbott brand OF bupivacaine hydrochloride

AC1L1DRE

AC1Q5LX4

AC-2096

AH 250

AKOS001637202

Anekain

Anhydrous, bupivacaine

AR-1A0242

Astra brand OF bupivacaine hydrochloride

AstraZeneca brand OF bupivacaine hydrochloride

Aventis brand OF bupivacaine hydrochloride

Bio-0886

Bloqueina

BPBio1_000298

Braun brand OF bupivacaine hydrochloride

Braun, bupivacaina

BRD-A01636364-003-05-2

BSPBio_000270

BSPBio_002607

Bucaine

Bucaine (TN)

Bupivacain janapharm

Bupivacain RPR

Bupivacaina

Bupivacaina [INN-Spanish]

Bupivacaina braun

bupivacaine

Bupivacaine

Bupivacaine (INN)

Bupivacaine [INN:BAN]

Bupivacaine anhydrous

Bupivacaine carbonate

Bupivacaine Carbonate

Bupivacaine HCL

Bupivacaine HCL kit

Bupivacaine HCL KIT

Bupivacaine hydrochloride

Bupivacaine monohydrochloride, monohydrate

Bupivacaine Monohydrochloride, Monohydrate

Bupivacain-RPR

Bupivacainum

Bupivacainum [INN-Latin]

Bupivan

Buvacaina

C07529

C18H28N2O

Carbonate, bupivacaine

Carbostesin

cBupivacaine

CBupivacaine

CHEBI:3215

CHEMBL1098

CID2474

D07552

DB00297

DepoBupivacaine

DivK1c_000758

dl-1-Butyl-2',6'-pipecoloxylidide

DL-Bupivacaine

Dolanaest

DUR-843

EINECS 218-553-3

EINECS 253-911-2

Exparel

HMS2090F12

Hydrochloride, bupivacaine

IDI1_000758

Inibsa brand OF bupivacaine hydrochloride

Janapharm, bupivacain

Jenapharm brand OF bupivacaine hydrochloride

KBio1_000758

KBio2_002004

KBio2_004572

KBio2_007140

KBio3_001827

KBioGR_001516

KBioSS_002004

KST-1A4609

L000695

LAC-43

LS-109841

LS-2222

Marcain

Marcaina

Marcaine

Marcaine HCL

Marcaine Spinal

MLS001361336

MolPort-004-955-820

NCGC00178579-01

NCGC00178579-02

NINDS_000758

NSC119660

Pisa brand OF bupivacaine hydrochloride

Prestwick0_000305

Prestwick1_000305

Prestwick2_000305

Prestwick3_000305

Racemic bupivacaine

Sensorcaine

Sensorcaine-MPF

Sensorcaine-MPF Spinal

SMR000058218

SPBio_001558

SPBio_002489

Spectrum_001524

Spectrum2_001589

Spectrum3_000974

Spectrum4_001098

Spectrum5_001483

Strathmann brand OF bupivacaine hydrochloride

Svedocain sin vasoconstr

Transdur-Bupivacaine

UNII-Y8335394RO

Win 11318

Win 11318 HCl

Anesthetics

Phase 4

Hypnotics and Sedatives

Phase 4

Proxymetacaine

Phase 4

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block	Not yet recruiting	NCT04346095	Phase 4	Oral Sedatives with or Without Analgesia;Intravenous Sedatives with or Without Analgesia
2	Cionni Ring and In-the-bag IOL Implantation for Subluxated Lenses: A Prospective Case Series	Completed	NCT01346566	Phase 3
3	Biometric Indicators of Eyes With Occult Lens Subluxation	Completed	NCT03752710
4	Ultrasound Biomicroscopic Analysis of Cionni Ring and In-the-bag IOL Implantation for Subluxated Lenses	Completed	NCT02790268
5	Efficacy of an Ocular Bandage Contact Lens for the Treatment of Dry Eye After Complicated and Combined Cataract Surgery	Recruiting	NCT04120389
6	Late In-the-bag intraOcular Lens dislocatioN Surgery: A Randomized Clinical Trial (LION Trial)	Recruiting	NCT03276104
7	Study of Subluxation Lens Biometrics and Postoperative Intraocular Lens Stability	Active, not recruiting	NCT04685122
8	Study of Multifunctional Cataract-assisted Retractor in Complicated Cataract Surgery	Active, not recruiting	NCT04062084
9	Late Dislocation of Intraocular Lens (IOL) Following Cataract Surgery: an Evaluation of Two Different Surgical Methods	Active, not recruiting	NCT01784926
10	CT Lucia 601 IOL Implantation in the Sulcus	Enrolling by invitation	NCT04796662

Search NIH Clinical Center for Lens Subluxation

Cochrane evidence based reviews: lens subluxation

Sources

Genetic Tests for Lens Subluxation

Genetic tests related to Lens Subluxation:

#	Genetic test	Affiliating Genes
1	Lens Subluxation ²⁹

Sources

Anatomical Context for Lens Subluxation

MalaCards organs/tissues related to Lens Subluxation:

⁴⁰

Eye, Endothelial, Retina, Skin

Sources

Publications for Lens Subluxation

Articles related to Lens Subluxation:

(show top 50) (show all 355)

#	Title	Authors	PMID	Year
1	Asymmetric pigmentary glaucoma in a patient with Marfan's syndrome. ⁵⁴ ⁶¹	Doyle A...Lachkar Y	15834601	2005
2	Determination of the molecular basis of Marfan syndrome: a growth industry. ⁵⁴ ⁶¹	Byers PH	15254580	2004
3	Visual outcomes of lens subluxation surgery with Cionni modified capsular tension rings in Marfan syndrome. ⁶¹	Chen T...Jiang Y	33542371	2021
4	Morphometric analysis of the lens in human aniridia and mouse Small eye. ⁶¹	Voskresenskaya A...Duncan MK	33248069	2021
5	The simply modified intrascleral fixation using round flange (SMURF) technique for intrascleral intraocular lens fixation. ⁶¹	Kim S...Kim JT	33594097	2021
6	Risk factors of intraocular lens dislocation following routine cataract surgery: a case-control study. ⁶¹	Fan Q...Yang J	33689608	2021
7	In-the-Bag Intraocular Lens Subluxation in a Patient with Exfoliation Glaucoma. ⁶¹	Rubin Panvini AM...Critser DB	33494866	2021
8	[Results of hybrid (femtosecond laser-assisted) phacoemulsification of hypermature cataract in patients with lens subluxation]. ⁶¹	Yusef YN...Alkhumidi K	33610148	2021
9	Scleral-Sutured Intraocular Lens Dislocations Secondary to Eyelet Fractures. ⁶¹	Watane A...Yannuzzi NA	32777376	2021
10	Pseudophakic Angle Closure Due to Vitreous Block Following Ureteroscopic Lithotripsy. ⁶¹	Petpiroon P...Supakontanasan W	33536795	2021
11	A novel approach for scleral fixation using Carlevale lens. ⁶¹	Fiore T...Cagini C	33517768	2021
12	Coexistence of bilateral macular edema and pale optic disc in the patient with Cohen syndrome. ⁶¹	Rakusiewicz K...Czeszyk A	33542958	2021
13	Cataract surgery in eyes with congenital ocular coloboma. ⁶¹	Phylactou M...Maurino V	32886164	2020
14	The prevalence of uveitis in a population of donkeys in the UK. ⁶¹	Bradley C...Sansom PG	32145036	2020
15	Crystalline Lens Subluxation Following Blunt Head Trauma. ⁶¹	Olm LK...Haygert CJ	33135625	2020
16	Iridoschisis-A Systematic Review. ⁶¹	Pieklarz B...Dmuchowska DA	33081187	2020
17	[Bilateral lens subluxation in Marfan's syndrome]. ⁶¹	Mathieu N...Bart P	32778349	2020
18	Secondary intraocular lens implantation using the flanged intrascleral fixation technique in pediatric aphakia: case series and review of literature. ⁶¹	Sternfeld A...Basti S	33045378	2020
19	Iris-Claw Lens Implantation in a Patient with Iridoschisis. ⁶¹	Pieklarz B...Mariak Z	32857754	2020
20	Outcomes of cataract surgery in pseudoexfoliation syndrome in England: 10-year retrospective cohort study. ⁶¹	Ong AY...Shalchi Z	32826704	2020
21	Evaluation of vitreous degeneration as a potential risk factor for retinal detachment after phacoemulsification in dogs. ⁶¹	West MC...Rose MD	32472635	2020
22	Incidence and management of rhegmatogenous retinal detachment after pars plana vitrectomy and sutureless scleral-fixated intraocular lens. ⁶¹	Kumar K...Ramasamy K	32587183	2020
23	Persistent Fetal Vasculature With Subluxated Lens, Posterior Segment Pathology, and Bifid Fibrous Membrane: An Atypical Presentation. ⁶¹	Khokhar S...Dhull C	32579685	2020
24	Pharmacologic pupillary constriction after dilated fundus examination for ectopia lentis to prevent further subluxation. ⁶¹	Plum W...Woreta FA	32300672	2020
25	Cataract extraction in patients with primary congenital glaucoma. ⁶¹	Morales-Fernandez L...Garcia-Feijoo J	30957520	2020
26	Trans-scleral plugs fixated IOL: a new paradigm for sutureless scleral fixation. ⁶¹	Barca F...Rizzo S	32358266	2020
27	New surgical approach for sutureless scleral fixation. ⁶¹	Veronese C...Ciardella AP	32000520	2020
28	Late spontaneous bilateral intraocular lens subluxation accompanied with intraocular pressure elevation in a patient with acromegaly. ⁶¹	Chang YH...Chen SN	32874848	2020
29	Biometric indicators of eyes with occult lens subluxation inducing secondary acute angle closure. ⁶¹	Xing X...Liu A	32138781	2020
30	[Scleral-fixated intraocular lenses with Z‑suture technique for lens subluxation associated with spherophakia]. ⁶¹	Bocque C...Januschowski K	31222453	2020
31	Retinal break associated with traumatic lens dislocation or subluxation requiring vitrectomy. ⁶¹	Ke G...Gu Y	31781882	2020
32	Visibility of the Retina Through an Air-Filled Anterior Chamber During Simultaneous Vitrectomy and Descemet's Stripping Automated Endothelial Keratoplasty. ⁶¹	Yokogawa H...Sugiyama K	32801620	2020
33	[Differentiated method of surgical prophylaxis against anterior capsular contraction syndrome during phacoemulsification]. ⁶¹	Yusef YN...Fokina ND	33063965	2020
34	Comparisons of Ocular Anatomic Differences of Lens-Subluxated Eye with or without Acute Angle Closure: A Retrospective Study. ⁶¹	Lin HL...Zhang HY	32802489	2020
35	Epidemiology of Eye Injuries Resulting in Hospitalization, a Referral Hospital-Based Study. ⁶¹	Choovuthayakorn J...Tananuvat N	32021063	2020
36	Big Bag IOL Implantation with Scleral Fixation Technique in IOL/Crystalline Lens Subluxation/Luxation Cases and High Myopia. ⁶¹	Nuzzi R...Monteu F	32943945	2020
37	[Comparative evaluation of positional stability of the «capsular bag + intraocular lens» complex in patients with lens subluxation]. ⁶¹	Yusef YN...Sharnina TV	32779463	2020
38	"Sutureless scleral fixation using Carlevale lens: surgical and refractive outcomes". ⁶¹	Barca F...Rizzo S	32347697	2020
39	Doubles trouble-85 cases of ocular trauma in badminton: clinical features and prevention. ⁶¹	Yu J...Liu Y	30988018	2020
40	Evaluation of functional outcome and stability of sutureless scleral tunnel fixated IOLs in children with ectopia lentis. ⁶¹	Rastogi A...Bhardwaj A	31956572	2020
41	Double-Flanged polypropylene Suture for Scleral Fixation of Cionni Capsule Tension Ring. ⁶¹	Samir A...Lotfy A	32368003	2020
42	Femtosecond laser-assisted cataract surgery in a spherophakic lens: An unusual case report. ⁶¹	Cao D...Wang L	31689746	2019
43	Pseudoexfoliative Proliferation and Lens Subluxation. ⁶¹	Fleischman D...Jones V	32672571	2019
44	Eye injury and demographic parameters associated with poor visual outcome. ⁶¹	Jovanovic N...Musa S	31122763	2019
45	Intraoperative and postoperative complications of cataract surgery in eyes with pseudoexfoliation - An 8-year analysis. ⁶¹	Thevi T...Abas AL	31902990	2019
46	[Bilateral posterior lens subluxation in the context of physical abuse: Case report]. ⁶¹	Fossum P...Deltour JB	31130383	2019
47	Is specialized ophthalmologic evaluation necessary after orbital fractures? A prospective 64-case study. ⁶¹	Marano R...Oliveira L	31104221	2019
48	Irreversible Ocular Lesions in a Dog With Angiostrongylus Vasorum Infection. ⁶¹	Ciuca L...Lamagna B	31472726	2019
49	Neglected Congenital Glaucoma With Lens Coloboma. ⁶¹	Dhingra D...Kaushik S	31135584	2019
50	[Application of femtosecond laser technology in the management of subluxated lens]. ⁶¹	Ju R...Wu Z	31340919	2019

Sources

Genes for Lens Subluxation

Genes related to Lens Subluxation (2 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	FBN1	Fibrillin 1	Protein Coding	454.34	Pathogenic ⁶ Likely pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Variants (show sections)	15834601 15254580
2	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	407.11	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)
3	P3H2	Prolyl 3-Hydroxylase 2	Protein Coding	21.23	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
4	VSX2	Visual System Homeobox 2	Protein Coding	12.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	11.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CBS	Cystathionine Beta-Synthase	Protein Coding	6.89	GeneCards inferred via : Publications (show sections)
7	GALT	Galactose-1-Phosphate Uridylyltransferase	Protein Coding	6.89	GeneCards inferred via : Publications (show sections)
8	CRYAA	Crystallin Alpha A	Protein Coding	6.86	DISEASES inferred ¹⁵ ¹⁵
9	LOXL1	Lysyl Oxidase Like 1	Protein Coding	6.7	DISEASES inferred ¹⁵
10	ADAMTS10	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 10	Protein Coding	6.63	DISEASES inferred ¹⁵
11	ADAMTS17	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17	Protein Coding	6.42	DISEASES inferred ¹⁵
12	PAX6	Paired Box 6	Protein Coding	6.33	DISEASES inferred ¹⁵
13	ADAMTSL4	ADAMTS Like 4	Protein Coding	6.11	DISEASES inferred ¹⁵
14	BFSP1	Beaded Filament Structural Protein 1	Protein Coding	6.08	DISEASES inferred ¹⁵
15	IQCK	IQ Motif Containing K	Protein Coding	5.95	DISEASES inferred ¹⁵
16	LTBP2	Latent Transforming Growth Factor Beta Binding Protein 2	Protein Coding	5.8	DISEASES inferred ¹⁵
17	CRYBA2	Crystallin Beta A2	Protein Coding	5.66	DISEASES inferred ¹⁵
18	CRYBA4	Crystallin Beta A4	Protein Coding	5.66	DISEASES inferred ¹⁵
19	CBSL	Cystathionine Beta-Synthase Like	Protein Coding	5.64	DISEASES inferred ¹⁵
20	ADAMTSL2	ADAMTS Like 2	Protein Coding	5.6	DISEASES inferred ¹⁵
21	SUOX	Sulfite Oxidase	Protein Coding	5.44	DISEASES inferred ¹⁵

Sources

Variations for Lens Subluxation

ClinVar genetic disease variations for Lens Subluxation:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	TFAP2A	NM_001032280.3(TFAP2A):c.1019_1020del (p.Lys340fs)	Deletion	Pathogenic	523459	rs1554110735	GRCh37: 6:10398926-10398927 GRCh38: 6:10398693-10398694
2	FBN1	NM_000138.5(FBN1):c.364C>T	SNV	Pathogenic	16440	rs137854467	GRCh37: 15:48892414-48892414 GRCh38: 15:48600217-48600217
3	FBN1	NM_000138.4(FBN1):c.1481G>T (p.Cys494Phe)	SNV	Likely pathogenic	374079	rs1057518881	GRCh37: 15:48805853-48805853 GRCh38: 15:48513656-48513656

Sources

Expression for Lens Subluxation

Search GEO for disease gene expression data for Lens Subluxation.

Sources

Pathways for Lens Subluxation

Pathways related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	O-linked glycosylation ⁶⁵ Show member pathways O-linked glycosylation of mucins ⁶⁵	11.72	ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
2	Diseases of glycosylation ⁶⁵ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁵	11.42	ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
3	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	11.36	LTBP2 LOXL1 FBN1
4	O-glycosylation of TSR domain-containing proteins ⁶⁵ Show member pathways Defective B3GALTL causes Peters-plus syndrome (PpS) ⁶⁵	10.81	ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
5	Folate-Alcohol and Cancer Pathway ¹	10.16	MTHFR CBS

Sources

GO Terms for Lens Subluxation

Cellular components related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	basement membrane	GO:0005604	9.43	P3H2 LOXL1 FBN1
2	collagen-containing extracellular matrix	GO:0062023	9.35	LTBP2 LOXL1 FBN1 ADAMTSL4 ADAMTS10
3	extracellular matrix	GO:0031012	9.17	LTBP2 LOXL1 FBN1 ADAMTSL4 ADAMTSL2 ADAMTS17
4	microfibril	GO:0001527	9.16	FBN1 ADAMTS10

Biological processes related to Lens Subluxation according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	camera-type eye development	GO:0043010	9.72	PAX6 FBN1 CRYBA4
2	lens development in camera-type eye	GO:0002088	9.65	PAX6 CRYBA4 CRYBA2
3	visual perception	GO:0007601	9.55	VSX2 PAX6 CRYBA4 CRYBA2 CRYAA
4	L-serine metabolic process	GO:0006563	9.54	CBSL CBS
5	DNA protection	GO:0042262	9.52	CBSL CBS
6	transsulfuration	GO:0019346	9.51	CBSL CBS
7	L-serine catabolic process	GO:0006565	9.49	CBSL CBS
8	hydrogen sulfide biosynthetic process	GO:0070814	9.46	CBSL CBS
9	homocysteine catabolic process	GO:0043418	9.43	CBSL CBS
10	L-cysteine catabolic process	GO:0019448	9.4	CBSL CBS
11	cysteine biosynthetic process	GO:0019344	9.37	CBSL CBS
12	cysteine biosynthetic process via cystathionine	GO:0019343	9.32	CBSL CBS
13	cysteine biosynthetic process from serine	GO:0006535	9.26	CBSL CBS
14	homocysteine metabolic process	GO:0050667	9.13	MTHFR CBSL CBS
15	extracellular matrix organization	GO:0030198	9.1	LOXL1 FBN1 ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10

Molecular functions related to Lens Subluxation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	10.06	TFAP2A FBN1 CRYBA4 CRYBA2 CRYAA CBSL
2	metalloendopeptidase activity	GO:0004222	9.62	ADAMTSL4 ADAMTSL2 ADAMTS17 ADAMTS10
3	S-adenosyl-L-methionine binding	GO:1904047	9.48	CBSL CBS
4	nitrite reductase (NO-forming) activity	GO:0050421	9.43	CBSL CBS
5	nitric oxide binding	GO:0070026	9.4	CBSL CBS
6	microfibril binding	GO:0050436	9.37	LTBP2 ADAMTSL2
7	cystathionine beta-synthase activity	GO:0004122	9.26	CBSL CBS
8	carbon monoxide binding	GO:0070025	9.16	CBS CBSL
9	modified amino acid binding	GO:0072341	9.13	MTHFR CBSL CBS
10	structural constituent of eye lens	GO:0005212	8.92	CRYBA4 CRYBA2 CRYAA BFSP1

Sources

Sources for Lens Subluxation

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia