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MCID: LNT004
MIFTS: 49

Lentigines

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lentigines

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MalaCards integrated aliases for Lentigines:

Name: Lentigines 57 55
Lentigo 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
lentigines:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 57 150900
MedGen 42 C0023321
UMLS 73 C0023321
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Summaries for Lentigines

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MalaCards based summary : Lentigines, also known as lentigo, is related to noonan syndrome with multiple lentigines and melanocytic nevus syndrome, congenital. An important gene associated with Lentigines is PTPN11 (Protein Tyrosine Phosphatase, Non-Receptor Type 11), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and lymph node, and related phenotypes are nystagmus and abnormality of the skin

Wikipedia : 76 A lentigo (/lɛnˈtaɪɡoʊ/) (plural lentigines, /lɛnˈtɪdʒɪniːz/) is a small pigmented spot on the skin with... more...

Description from OMIM: 150900
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Related Diseases for Lentigines

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Diseases related to Lentigines via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 noonan syndrome with multiple lentigines 32.7 BRAF PTPN11 RAF1
2 melanocytic nevus syndrome, congenital 31.6 MC1R PRKAR1A
3 leopard syndrome 31.3 BRAF PTPN11 RAF1
4 noonan syndrome 1 30.8 BRAF PTPN11 RAF1
5 acral lentiginous melanoma 12.5
6 leopard syndrome 1 11.9
7 gastrocutaneous syndrome 11.5
8 carney complex variant 11.2
9 phacomatosis pigmentokeratotica 11.2
10 phakomatosis pigmentokeratotica 11.2
11 lentiginosis, inherited patterned 11.0
12 uv-sensitive syndrome 11.0
13 nevoid hypermelanosis, linear and whorled 10.9
14 spastic paraplegia 23 10.8
15 legius syndrome 10.8
16 leopard syndrome 2 10.8
17 leopard syndrome 3 10.8
18 melanoma 10.7
19 pseudo-turner syndrome 10.2
20 peutz-jeghers syndrome 10.1
21 dengue disease 9.9 PTPN11 RAF1
22 gastrointestinal stromal tumor 9.9
23 mucositis 9.9
24 sarcoma 9.9
25 hypertrophic cardiomyopathy 9.9
26 neurofibromatosis, type i 9.8
27 neurofibromatosis, type iv, of riccardi 9.8
28 mycosis fungoides 9.8
29 dyschromatosis universalis hereditaria 9.8
30 urticaria pigmentosa 9.8
31 urticaria 9.8
32 lipomatosis 9.8
33 pituitary adenoma 9.8
34 adenoma 9.8
35 neuropathy 9.8
36 psoriasis 9.8
37 maculopapular cutaneous mastocytosis 9.8
38 spitz nevus 9.8
39 superficial spreading melanoma 9.8
40 cardiofaciocutaneous syndrome 1 9.7 BRAF PTPN11
41 nevus, epidermal 9.6
42 renal hypodysplasia/aplasia 1 9.6
43 myeloma, multiple 9.6
44 netherton syndrome 9.6
45 basal cell carcinoma 1 9.6
46 psoriatic arthritis 9.6
47 testicular microlithiasis 9.6
48 renal hypodysplasia/aplasia 3 9.6
49 arthritis 9.6
50 craniosynostosis 9.6

Graphical network of the top 20 diseases related to Lentigines:



Diseases related to Lentigines
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Symptoms & Phenotypes for Lentigines

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Symptoms via clinical synopsis from OMIM:

57
Skin:
lentigines

Eyes:
nystagmus


Clinical features from OMIM:

150900

Human phenotypes related to Lentigines:

32
# Description HPO Frequency HPO Source Accession
1 nystagmus 32 HP:0000639
2 abnormality of the skin 32 HP:0000951

GenomeRNAi Phenotypes related to Lentigines according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 BRAF
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.7 RAF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.7 PTPN11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.7 PTPN11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.7 PTPN11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.7 RAF1 BRAF PTPN11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.7 RAF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.7 RAF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.7 BRAF
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.7 BRAF
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.7 PTPN11
12 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.7 PTPN11
13 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.7 BRAF
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.7 BRAF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.7 BRAF
16 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.7 BRAF
17 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.7 PTPN11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.7 PTPN11 BRAF
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.7 RAF1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.7 PTPN11
21 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.7 PTPN11

MGI Mouse Phenotypes related to Lentigines:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 BRAF MC1R PRKAR1A PTPN11 RAF1
2 cellular MP:0005384 9.95 BRAF MC1R PRKAR1A PTPN11 RAF1
3 craniofacial MP:0005382 9.93 BRAF MC1R PRKAR1A PTPN11 RAF1
4 growth/size/body region MP:0005378 9.91 BRAF MC1R PRKAR1A PTPN11 RAF1
5 hematopoietic system MP:0005397 9.88 BRAF MC1R PRKAR1A PTPN11 RAF1
6 immune system MP:0005387 9.85 PRKAR1A PTPN11 RAF1 BRAF MC1R
7 embryo MP:0005380 9.83 BRAF PRKAR1A PTPN11 RAF1
8 integument MP:0010771 9.83 MC1R PRKAR1A PTPN11 RAF1 BRAF
9 hearing/vestibular/ear MP:0005377 9.8 BRAF MC1R PTPN11 RAF1
10 neoplasm MP:0002006 9.72 BRAF MC1R PRKAR1A PTPN11 RAF1
11 liver/biliary system MP:0005370 9.71 BRAF PRKAR1A PTPN11 RAF1
12 muscle MP:0005369 9.67 BRAF PRKAR1A PTPN11 RAF1
13 normal MP:0002873 9.56 RAF1 BRAF PRKAR1A PTPN11
14 pigmentation MP:0001186 9.46 BRAF MC1R PRKAR1A PTPN11
15 respiratory system MP:0005388 9.26 BRAF PRKAR1A PTPN11 RAF1
16 vision/eye MP:0005391 8.92 BRAF PRKAR1A PTPN11 RAF1
Sources

Drugs & Therapeutics for Lentigines

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Drugs for Lentigines (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 3 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 99011-02-6 57469
3 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Photosensitizing Agents Phase 4,Phase 3
5 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Not Applicable
6 Interferon Inducers Phase 4,Phase 3,Phase 2,Not Applicable
7 interferons Phase 4,Phase 3,Phase 2,Not Applicable
8
Adapalene Approved Phase 3 106685-40-9 60164
9
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 5538 444795
10 Keratolytic Agents Phase 3,Phase 2,Not Applicable
11 Analgesics Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Antirheumatic Agents Phase 3
16 Emollients Phase 3
17 Peripheral Nervous System Agents Phase 3,Not Applicable
18 Methyl 5-aminolevulinate Phase 3
19
Glycolic acid Approved, Investigational Phase 2 79-14-1 757
20
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 2 67-73-2 6215
21
Hydroquinone Approved, Investigational Phase 2 123-31-9 785
22
Everolimus Approved Phase 2 159351-69-6 6442177
23
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
24
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
25
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
26
Cediranib Investigational Phase 2 288383-20-0 9933475
27
Maleic acid Experimental Phase 2 110-16-7 444266
28 Antioxidants Phase 2
29 Micronutrients Phase 2,Not Applicable
30 Protective Agents Phase 2
31 Trace Elements Phase 2,Not Applicable
32 Vitamins Phase 2,Not Applicable
33 glucocorticoids Phase 2,Not Applicable
34 Hormone Antagonists Phase 2,Not Applicable
35 Hormones Phase 2,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
37 Radiation-Protective Agents Phase 2
38 Protein Kinase Inhibitors Phase 2
39 Anti-Bacterial Agents Phase 2,Not Applicable
40 Antibiotics, Antitubercular Phase 2,Not Applicable
41 Anti-Infective Agents Phase 2,Phase 1
42 Antifungal Agents Phase 2
43 Immunosuppressive Agents Phase 2
44
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
45 Antiviral Agents Phase 1
46 Ganciclovir triphosphate Phase 1
47 Nucleic Acid Synthesis Inhibitors Phase 1
48
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
49
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
50
Tazarotene Approved, Investigational Not Applicable 118292-40-3 5381

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Completed NCT02685592 Phase 4 5-aminolevulinic acid nanoemulsion
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Clinical Study for the Evaluation of the Depigmenting Activity of a Cosmetic Product on Spotted Hand Skin Completed NCT02204436 Phase 3
4 Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage Completed NCT00647556 Phase 3 adapalene gel, 0.3%;tretinoin 0.05% emollient cream
5 Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusion Completed NCT00926952 Phase 3 Methylaminolevulinate (Metvix, Metvixia)
6 Radiotherapy or Imiquimod in Complex Lentigo Maligna Recruiting NCT02394132 Phase 3 Imiquimod
7 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
8 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Active, not recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
9 The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging Unknown status NCT02126644 Phase 2 70% glycolic acid
10 Solar Lentigines Treatment With the Triple Combination Cream Completed NCT00975312 Phase 2 Triple combination cream;Tretinoin 0.05%
11 Side Effects of Q-Switched Ruby Laser for the Treatment of Lentigines in Light and Dark Skin Types Completed NCT00386204 Phase 2
12 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2 cediranib maleate
13 Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face Recruiting NCT02723721 Phase 2 Picato gel
14 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
15 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
16 Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome Terminated NCT00811590 Phase 2 Everolimus
17 Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome Withdrawn NCT01178151 Phase 2 Everolimus
18 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
19 Evaluate the Lightening Effect of the Whitening Cosmetic Product BEX-2011 Unknown status NCT01249469 Not Applicable
20 Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion Unknown status NCT01136629
21 Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes Unknown status NCT02486731
22 A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy Completed NCT01778179 Not Applicable Tri-luma
23 Comparative Study of the Therapy of Solar Lentigines With a Q-switched Rubin Laser Versus a Bleaching Cream Completed NCT02153697 Not Applicable Pigmanorm Cream
24 A Single-Center 2-Arm Study for Lentigines on the Hands Completed NCT02763072 Not Applicable
25 Assessment of CRYOBEAUTY MAINS ET DECOLLETE Versus Liquid Nitrogen Cryotherapy, in the Treatment of Solar Lentigines Completed NCT03225729 Not Applicable
26 Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy Completed NCT03457246 Not Applicable
27 A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin Completed NCT02385994 Not Applicable
28 Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna Completed NCT00707174 Not Applicable Imiquimod Cream;Tazarotene Cream 0.1%
29 Study for the RevLite Laser System for Facial Solar Lentigines Completed NCT02110108 Not Applicable
30 Laser Removal of Age (Sun) Spots on Hands Completed NCT01885871 Not Applicable
31 Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers. Completed NCT03157427 Not Applicable
32 Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser Completed NCT02492373 Not Applicable topical 0.05% Clobetasol propionate ointment
33 Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC) Completed NCT00668291
34 In Vivo Confocal Microscopy for Pigmented Lesion Diagnosis Completed NCT00785369 Not Applicable
35 Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin Completed NCT00875381
36 Hereditary Colorectal and Associated Tumor Registry Study Completed NCT00633607
37 Cancer of the Pancreas Screening Study (CAPS 3) Completed NCT00438906 Secretin (human synthetic) - ChiRhoClin
38 Reflectance Confocal Microscopy to Diagnose MM & LM Recruiting NCT03508297
39 Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex Recruiting NCT00001452
40 VELOS for the Treatment of Vascular Lesions and Skin Rejuvenation Recruiting NCT02468453 Not Applicable
41 Study of Families With Melanoma Recruiting NCT00445783
42 French Clinical Datbase of Melanoma Patients (RIC-Mel) Recruiting NCT03315468
43 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
44 Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer Recruiting NCT03030404
45 Pancreatic Cancer Early Detection Program Recruiting NCT02206360
46 The Cancer of the Pancreas Screening-5 CAPS5)Study Recruiting NCT02000089 Human synthetic secretin
47 The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser Active, not recruiting NCT02427724 Not Applicable lidocaine 2.5%/prilocaine 2.5% topical anesthetic;lidocaine 7%/tetracaine 7% topical anesthetic;placebo vehicle
48 Pancreatic Cancer Screening of High-Risk Individuals in Arkansas Active, not recruiting NCT02309632 Not Applicable
49 Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder Not yet recruiting NCT03578315 Not Applicable
50 Comparison of 1,550-nm Laser and Fractional Radiofrequency Microneedle for the Treatment of Acne Scars in Ethnic Skin Not yet recruiting NCT03380845 Not Applicable

Search NIH Clinical Center for Lentigines

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Genetic Tests for Lentigines

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Anatomical Context for Lentigines

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MalaCards organs/tissues related to Lentigines:

41
Skin, Pancreas, Lymph Node, Pituitary, Colon, Brain
Sources

Publications for Lentigines

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Articles related to Lentigines:

(show top 50) (show all 242)
# Title Authors Year
1
Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. ( 29948457 )
2018
2
High density of M2-macrophages in acral lentiginous melanoma compared to superficial spreading melanoma. ( 29415335 )
2018
3
Acral lentiginous melanoma. ( 29900875 )
2018
4
Multiple Lentigines Arising in Sites of Resolving Psoriatic Plaques after Treatment with Ustekinumab. ( 29853759 )
2018
5
Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival. ( 29860247 )
2018
6
Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis. ( 29847461 )
2018
7
A prospective, randomized, double-blinded, split-face pilot study comparing Q-switched 1064-nm Nd:YAG versus 532-nm Nd:YAG laser for the treatment of solar lentigines. ( 29482397 )
2018
8
Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. ( 29923175 )
2018
9
Multiple lentigines arising on resolving psoriatic plaques after treatment with apremilast. ( 29926507 )
2018
10
Noonan syndrome with multiple lentigines and associated craniosynostosis. ( 29356064 )
2018
11
Prognostic features for acral lentiginous melanoma. ( 29441559 )
2018
12
Removal of forearm lentigines in dyschromatosis universalis hereditaria with a 755-nm Q-switched alexandrite laser. ( 29379862 )
2018
13
Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen. ( 29673774 )
2018
14
Prospective study of removing solar lentigines in Asians using a novel dual-wavelength and dual-pulse width picosecond laser. ( 29608215 )
2018
15
Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis. ( 29785333 )
2018
16
Importance of cardiovascular examination in patients with multiple lentigines: two cases of LEOPARD syndrome with hypertrophic cardiomyopathy. ( 29717636 )
2018
17
Diagnosis and Management of Acral Lentiginous Melanoma. ( 29951919 )
2018
18
Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma. ( 28224164 )
2017
19
A Novel De novo Mutation of the SASH1 Gene in a Chinese Family with Multiple Lentigines. ( 27840890 )
2017
20
Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey. ( 27786580 )
2017
21
Familial gastrointestinal stromal tumors, lentigines, and cafAc-au-lait macules associated with germline c-kit mutation treated with imatinib. ( 28074523 )
2017
22
Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report. ( 28566910 )
2017
23
Acral lentiginous melanoma versus other melanoma: A single-center analysis in Japan. ( 28342269 )
2017
24
In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy. ( 28582432 )
2017
25
Tumor infiltrating lymphocytes in acral lentiginous melanoma: a study of a large cohort of cases from Latin America. ( 28577153 )
2017
26
Insulin-Like Growth Factor-II mRNA-Binding Protein 3 as a Novel Prognostic Biomarker for Acral Lentiginous Melanoma. ( 29048737 )
2017
27
Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma. ( 28567312 )
2017
28
Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines. ( 28911943 )
2017
29
Response to the commentary on 'A genome-wide association study in Caucasian women suggests the involvement of HLA gene in the severity of facial solar lentigines'. ( 27804239 )
2017
30
The role of access to care in acral lentiginous melanoma survival. ( 28833024 )
2017
31
Noonan syndrome with multiple lentigines with PTPN11 (T468M) gene mutation accompanied with solitary granular cell tumor. ( 28681392 )
2017
32
Picosecond 532 nm Neodymium-Doped Yttrium Aluminium Garnet Laser for the Treatment of Solar Lentigines in Darker Skin Types: Safety and Efficacy. ( 27662050 )
2017
33
Prognostic factors and survival in acral lentiginous melanoma. ( 28432682 )
2017
34
Acral lentiginous melanoma - a skin cancer with unfavourable prognostic features. A study of the German Central Malignant Melanoma Registry (CMMR) in 2050 patients. ( 28707317 )
2017
35
Urticaria Pigmentosa Mimicking Multiple Lentigine-like Brownish Macules in a 22-Month-Old Boy. ( 28480643 )
2017
36
Focal regression of a primary melanoma, fading lentigines and poliosis in metastatic melanoma treated with anti-PD-1. ( 29114959 )
2017
37
The association between Solar Lentigines and Type-2 Diabetes. ( 29201325 )
2017
38
Overexpression of Human Leukocyte Antigen-G and Interleukin 10 in acral lentiginous melanoma. ( 28587737 )
2017
39
Double Primary Acral Lentiginous Melanoma of both Soles. ( 28223769 )
2017
40
Unwanted lentigines after topical tacrolimus for vitiligo. ( 28762481 )
2017
41
Acral lentiginous melanoma with dematiaceous fungal elements of Chaetomium globosum: A saprophytism or coexistence of superficial phaeohyphomycosis? ( 28836689 )
2017
42
Cochlear implantation and clinical features in patients with Noonan syndrome and Noonan syndrome with multiple lentigines caused by a mutation in PTPN11. ( 28483241 )
2017
43
A Prospective Trial Comparing Q-Switched Ruby Laser and a Triple Combination Skin-Lightening Cream in the Treatment of Solar Lentigines. ( 27341683 )
2016
44
Multiple giant cell lesions in a patient with Noonan syndrome with multiple lentigines. ( 27238887 )
2016
45
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man. ( 26838298 )
2016
46
Disseminated plantar lentigines associated with Peutz-Jeghers syndrome. ( 27173455 )
2016
47
Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. ( 27518480 )
2016
48
A genome-wide association study in Caucasian women suggests the involvement of HLA genes in the severity of facial solar lentigines. ( 27327535 )
2016
49
Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines. ( 27348588 )
2016
50
Acral Lentiginous Melanoma. ( 26601870 )
2016
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Variations for Lentigines

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Expression for Lentigines

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Search GEO for disease gene expression data for Lentigines.
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Pathways for Lentigines

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Pathways related to Lentigines according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Sertoli-Sertoli Cell Junction Dynamics 64
Show member pathways
 12.65 BRAF PRKAR1A RAF1
2
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.63 BRAF PTPN11 RAF1
3
CCR5 Pathway in Macrophages 64
Show member pathways
 12.61 BRAF PRKAR1A RAF1
4
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.6 BRAF PRKAR1A RAF1
5
Endometrial cancer 37
Show member pathways
 12.59 BRAF PTPN11 RAF1
6
IL-2 Pathway 64
Show member pathways
 12.53 BRAF PRKAR1A RAF1
7
Beta-Adrenergic Signaling 64
Show member pathways
 12.53 BRAF PRKAR1A RAF1
8
Ras signaling pathway 37
Show member pathways
 12.45 BRAF PTPN11 RAF1
9
Development HGF signaling pathway 22
Show member pathways
 12.43 BRAF PTPN11 RAF1
10
G-AlphaQ Signaling 64
Show member pathways
 12.38 BRAF PRKAR1A RAF1
11
Neuropathic Pain-Signaling in Dorsal Horn Neurons 64
Show member pathways
 12.37 BRAF PRKAR1A RAF1
12
Development Dopamine D2 receptor transactivation of EGFR 22
Show member pathways
 12.26 PRKAR1A PTPN11 RAF1
13
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.2 BRAF PTPN11 RAF1
14
ErbB signaling pathway 1 37
Show member pathways
 12.13 BRAF PTPN11 RAF1
15
Regulation of lipid metabolism Insulin signaling-generic cascades 22
Show member pathways
 12.03 BRAF PRKAR1A PTPN11 RAF1
16
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.02 BRAF PTPN11 RAF1
17
B cell receptor signaling pathway (KEGG) 37
Show member pathways
 11.98 BRAF PTPN11 RAF1
18
G-protein signaling G-Protein alpha-i signaling cascades 22
Show member pathways
 11.95 BRAF PRKAR1A RAF1
19
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 11.85 BRAF RAF1
20
Proteoglycans in cancer 37
11.85 BRAF PTPN11 RAF1
21
Glioblastoma Multiforme 64
11.75 BRAF RAF1
22
Parathyroid hormone synthesis, secretion and action 37
11.73 BRAF RAF1
23
Senescence and Autophagy in Cancer 1
11.73 BRAF RAF1
24
ErbB1 downstream signaling 1
11.71 BRAF RAF1
25
EGF/EGFR Signaling Pathway 1
11.71 BRAF PTPN11 RAF1
26
Development EPO-induced Jak-STAT pathway 22
Show member pathways
 11.68 PTPN11 RAF1
27
TGF-beta Signaling Pathways 65
11.68 BRAF RAF1
28
Corticotropin-releasing hormone signaling pathway 1
11.66 BRAF RAF1
29
Development EGFR signaling via small GTPases 22
Show member pathways
 11.61 PRKAR1A PTPN11 RAF1
30
VEGF Pathway (Tocris) 72
Show member pathways
 11.59 BRAF RAF1
31
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 11.59 BRAF PTPN11 RAF1
32
Bladder cancer 37 1
11.53 BRAF RAF1
33
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.49 BRAF RAF1
34
Negative regulation of MAPK pathway 66
Show member pathways
 11.46 BRAF RAF1
35
G-protein signaling TC21 regulation pathway 22
Show member pathways
 11.43 BRAF RAF1
36
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.43 BRAF RAF1
37
mTOR signaling pathway (Pathway Interaction Database) 1
11.43 BRAF RAF1
38
Long-term depression 37
11.42 BRAF RAF1
39
Signaling events mediated by focal adhesion kinase 1
11.36 BRAF RAF1
40
G-protein signaling_Rap1A regulation pathway 22
11.32 BRAF RAF1
41
Immune response_Role of integrins in NK cells cytotoxicity 22
11.24 PTPN11 RAF1
42
Interleukin-11 Signaling Pathway 1
11.23 PTPN11 RAF1
43
Vemurafenib Pathway, Pharmacodynamics 61
11.21 BRAF RAF1
44
Melanocyte Development and Pigmentation 64
11.19 MC1R PRKAR1A
45
Immune response_IL-6 signaling pathway 22
11.08 PTPN11 RAF1
46
Trk receptor signaling mediated by the MAPK pathway 1
Show member pathways
 11.03 BRAF RAF1
47
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 11 PTPN11 RAF1
48
IGF1 pathway 1
10.94 PTPN11 RAF1
49
G-protein signaling_K-RAS regulation pathway 22
10.91 BRAF RAF1
50
MAP Kinase Signaling 4
10.85 BRAF PTPN11 RAF1
Sources

GO Terms for Lentigines

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Biological processes related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.5 PRKAR1A PTPN11 RAF1
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.48 BRAF RAF1
3 somatic stem cell population maintenance GO:0035019 9.46 BRAF RAF1
4 activation of MAPKK activity GO:0000186 9.43 BRAF RAF1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.43 BRAF PTPN11 RAF1
6 thymus development GO:0048538 9.4 BRAF RAF1
7 thyroid gland development GO:0030878 9.37 BRAF RAF1
8 face development GO:0060324 9.16 BRAF RAF1
9 neurotrophin TRK receptor signaling pathway GO:0048011 8.96 PTPN11 RAF1
10 intracellular signal transduction GO:0035556 8.92 BRAF MC1R PRKAR1A RAF1

Molecular functions related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.32 BRAF RAF1
2 mitogen-activated protein kinase kinase binding GO:0031434 9.26 BRAF RAF1
3 small GTPase binding GO:0031267 9.16 BRAF RAF1
4 obsolete signal transducer activity, downstream of receptor GO:0005057 8.96 BRAF RAF1
5 Ras GTPase binding GO:0017016 8.62 BRAF RAF1
Sources

Sources for Lentigines

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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