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MCID: LNT004
MIFTS: 51

Lentigines

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Lentigines

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MalaCards integrated aliases for Lentigines:

Name: Lentigines 57 55
Lentigo 73

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
lentigines:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM 57 150900
MedGen 42 C0023321
UMLS 73 C0023321
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Summaries for Lentigines

About this section
MalaCards based summary : Lentigines, also known as lentigo, is related to noonan syndrome with multiple lentigines and melanocytic nevus syndrome, congenital. An important gene associated with Lentigines is PTPN11 (Protein Tyrosine Phosphatase, Non-Receptor Type 11), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and CCR5 Pathway in Macrophages. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, cortex and bone, and related phenotypes are nystagmus and abnormality of the skin

Wikipedia : 76 A lentigo (/l�?n�?taɪɡo�?/) (plural lentigines, /l�?n�?tɪd�?ɪniːz/) is a small pigmented spot on the... more...

Description from OMIM: 150900
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Related Diseases for Lentigines

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Diseases related to Lentigines via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 noonan syndrome with multiple lentigines 33.6 RAF1 PTPN11 BRAF
2 melanocytic nevus syndrome, congenital 32.4 MC1R PRKAR1A
3 leopard syndrome 32.2 RAF1 PTPN11 BRAF
4 noonan syndrome 1 31.7 BRAF PTPN11 RAF1
5 hypertrophic cardiomyopathy 29.7 BRAF PTPN11 RAF1
6 hypertelorism 29.3 RAF1 PTPN11 BRAF
7 acral lentiginous melanoma 12.6
8 leopard syndrome 1 12.0
9 gastrocutaneous syndrome 11.8
10 lentiginosis, inherited patterned 11.5
11 carney complex variant 11.3
12 phacomatosis pigmentokeratotica 11.3
13 phakomatosis pigmentokeratotica 11.3
14 uv-sensitive syndrome 11.1
15 nevoid hypermelanosis, linear and whorled 11.0
16 spastic paraplegia 23 11.0
17 legius syndrome 11.0
18 leopard syndrome 2 11.0
19 leopard syndrome 3 11.0
20 melanoma 10.9
21 pseudo-turner syndrome 10.4
22 peutz-jeghers syndrome 10.2
23 psoriasis 10.1
24 mycosis fungoides 10.0
25 nodular malignant melanoma 10.0
26 sarcoma 10.0
27 neuropathy 10.0
28 tièche-jadassohn nevus 10.0
29 cardiofaciocutaneous syndrome 1 9.9 BRAF PTPN11
30 noonan syndrome 3 9.9 RAF1 PTPN11
31 mastocytosis, cutaneous 9.9
32 neurofibromatosis, type i 9.9
33 gastrointestinal stromal tumor 9.9
34 mucosal melanoma 9.9
35 dyschromatosis universalis hereditaria 9.9
36 urticaria 9.9
37 dermatitis 9.9
38 lipomatosis 9.9
39 pituitary adenoma 9.9
40 adenoma 9.9
41 rosacea 9.9
42 spitz nevus 9.9
43 superficial spreading melanoma 9.9
44 pilomyxoid astrocytoma 9.9 BRAF RAF1
45 leukemia, chronic lymphocytic 2 9.9 PTPN11 BRAF
46 pulmonic stenosis 9.8 RAF1 PTPN11 BRAF
47 juvenile myelomonocytic leukemia 9.8 RAF1 PTPN11 BRAF
48 hernia, hiatus 9.8
49 systemic lupus erythematosus 9.8
50 nevus, epidermal 9.8

Graphical network of the top 20 diseases related to Lentigines:



Diseases related to Lentigines
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Symptoms & Phenotypes for Lentigines

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Symptoms via clinical synopsis from OMIM:

57
Eyes:
nystagmus

Skin:
lentigines


Clinical features from OMIM:

150900

Human phenotypes related to Lentigines:

32
# Description HPO Frequency HPO Source Accession
1 nystagmus 32 HP:0000639
2 abnormality of the skin 32 HP:0000951

GenomeRNAi Phenotypes related to Lentigines according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.68 BRAF
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.68 PTPN11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 PTPN11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 PTPN11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 BRAF PTPN11 RAF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.68 RAF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.68 RAF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.68 BRAF
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 BRAF
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.68 PTPN11
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.68 PTPN11
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.68 BRAF
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.68 BRAF
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.68 BRAF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 BRAF
16 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.68 PTPN11
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 BRAF PTPN11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.68 RAF1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 PTPN11
20 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 PTPN11

MGI Mouse Phenotypes related to Lentigines:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 BRAF MC1R PRKAR1A PTPN11 RAF1
2 cellular MP:0005384 9.95 BRAF MC1R PRKAR1A PTPN11 RAF1
3 craniofacial MP:0005382 9.93 BRAF MC1R PRKAR1A PTPN11 RAF1
4 growth/size/body region MP:0005378 9.91 BRAF MC1R PRKAR1A PTPN11 RAF1
5 hematopoietic system MP:0005397 9.88 BRAF MC1R PRKAR1A PTPN11 RAF1
6 immune system MP:0005387 9.85 BRAF MC1R PRKAR1A PTPN11 RAF1
7 embryo MP:0005380 9.83 BRAF PRKAR1A PTPN11 RAF1
8 integument MP:0010771 9.83 BRAF MC1R PRKAR1A PTPN11 RAF1
9 hearing/vestibular/ear MP:0005377 9.8 BRAF MC1R PTPN11 RAF1
10 neoplasm MP:0002006 9.72 BRAF MC1R PRKAR1A PTPN11 RAF1
11 liver/biliary system MP:0005370 9.71 BRAF PRKAR1A PTPN11 RAF1
12 muscle MP:0005369 9.67 BRAF PRKAR1A PTPN11 RAF1
13 normal MP:0002873 9.56 BRAF PRKAR1A PTPN11 RAF1
14 pigmentation MP:0001186 9.46 BRAF MC1R PRKAR1A PTPN11
15 respiratory system MP:0005388 9.26 BRAF PRKAR1A PTPN11 RAF1
16 vision/eye MP:0005391 8.92 BRAF PRKAR1A PTPN11 RAF1
Sources

Drugs & Therapeutics for Lentigines

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Drugs for Lentigines (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4,Phase 3 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 99011-02-6 57469
3 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Photosensitizing Agents Phase 4,Phase 3
5 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable
6 Interferon Inducers Phase 4,Phase 3,Phase 2,Not Applicable
7 interferons Phase 4,Phase 3,Phase 2,Not Applicable
8 Adjuvants, Immunologic Phase 4,Phase 3,Phase 2,Not Applicable
9
Adapalene Approved Phase 3 106685-40-9 60164
10
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 5538 444795
11 Keratolytic Agents Phase 3,Phase 2,Not Applicable
12 Emollients Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Peripheral Nervous System Agents Phase 3,Not Applicable
15 Analgesics Phase 3
16 Anti-Inflammatory Agents Phase 3,Phase 2,Not Applicable
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antirheumatic Agents Phase 3
19 Methyl 5-aminolevulinate Phase 3
20
Glycolic acid Approved, Investigational Phase 2 79-14-1 757
21
Hydroquinone Approved, Investigational Phase 2 123-31-9 785
22
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 2 67-73-2 6215
23
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
24
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
25
Everolimus Approved Phase 2 159351-69-6 6442177
26
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
27
Maleic acid Experimental Phase 2 110-16-7 444266
28
Cediranib Investigational Phase 2 288383-20-0 9933475
29 Antioxidants Phase 2
30 Protective Agents Phase 2
31 Micronutrients Phase 2,Not Applicable
32 Trace Elements Phase 2,Not Applicable
33 Vitamins Phase 2,Not Applicable
34 Radiation-Protective Agents Phase 2
35 glucocorticoids Phase 2,Not Applicable
36 Hormones Phase 2,Not Applicable
37 Hormone Antagonists Phase 2,Not Applicable
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
39 Protein Kinase Inhibitors Phase 2
40 Anti-Bacterial Agents Phase 2,Not Applicable
41 Anti-Infective Agents Phase 2,Phase 1
42 Antifungal Agents Phase 2
43 Antibiotics, Antitubercular Phase 2,Not Applicable
44 Immunosuppressive Agents Phase 2
45
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
46 Antiviral Agents Phase 1
47 Nucleic Acid Synthesis Inhibitors Phase 1
48 Ganciclovir triphosphate Phase 1
49
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
50
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream Completed NCT02685592 Phase 4 5-aminolevulinic acid nanoemulsion
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome Recruiting NCT03781050 Phase 4 Rapamycin
4 Radiotherapy or Imiquimod in Complex Lentigo Maligna Recruiting NCT02394132 Phase 3 Imiquimod
5 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
6 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Active, not recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
7 Clinical Study for the Evaluation of the Depigmenting Activity of a Cosmetic Product on Spotted Hand Skin Completed NCT02204436 Phase 3
8 Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage Completed NCT00647556 Phase 3 adapalene gel, 0.3%;tretinoin 0.05% emollient cream
9 Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusion Completed NCT00926952 Phase 3 Methylaminolevulinate (Metvix, Metvixia)
10 The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging Unknown status NCT02126644 Phase 2 70% glycolic acid
11 Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face Recruiting NCT02723721 Phase 2 Picato gel
12 Solar Lentigines Treatment With the Triple Combination Cream Completed NCT00975312 Phase 2 Triple combination cream;Tretinoin 0.05%
13 Side Effects of Q-Switched Ruby Laser for the Treatment of Lentigines in Light and Dark Skin Types Completed NCT00386204 Phase 2
14 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
15 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
16 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2 cediranib maleate
17 Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome Withdrawn NCT01178151 Phase 2 Everolimus
18 Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome Terminated NCT00811590 Phase 2 Everolimus
19 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
20 Evaluate the Lightening Effect of the Whitening Cosmetic Product BEX-2011 Unknown status NCT01249469 Not Applicable
21 Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion Unknown status NCT01136629
22 Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes Unknown status NCT02486731
23 A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy Completed NCT01778179 Not Applicable Tri-luma
24 Comparative Study of the Therapy of Solar Lentigines With a Q-switched Rubin Laser Versus a Bleaching Cream Completed NCT02153697 Not Applicable Pigmanorm Cream
25 A Single-Center 2-Arm Study for Lentigines on the Hands Completed NCT02763072 Not Applicable
26 Assessment of CRYOBEAUTY MAINS ET DECOLLETE Versus Liquid Nitrogen Cryotherapy, in the Treatment of Solar Lentigines Completed NCT03225729 Not Applicable
27 Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder Not yet recruiting NCT03578315 Not Applicable
28 Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy Completed NCT03457246 Not Applicable
29 A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin Completed NCT02385994 Not Applicable
30 Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna Completed NCT00707174 Not Applicable Imiquimod Cream;Tazarotene Cream 0.1%
31 Study for the RevLite Laser System for Facial Solar Lentigines Completed NCT02110108 Not Applicable
32 Laser Removal of Age (Sun) Spots on Hands Completed NCT01885871 Not Applicable
33 Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers. Completed NCT03157427 Not Applicable
34 Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser Completed NCT02492373 Not Applicable topical 0.05% Clobetasol propionate ointment
35 The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser Active, not recruiting NCT02427724 Not Applicable lidocaine 2.5%/prilocaine 2.5% topical anesthetic;lidocaine 7%/tetracaine 7% topical anesthetic;placebo vehicle
36 Reflectance Confocal Microscopy to Diagnose MM & LM Recruiting NCT03508297
37 Mohs and Immunofluorescence for Malignant Melanoma In Situ Withdrawn NCT02306512 Not Applicable
38 Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC) Completed NCT00668291
39 In Vivo Confocal Microscopy for Pigmented Lesion Diagnosis Completed NCT00785369 Not Applicable
40 Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex Recruiting NCT00001452
41 Comparison of 1,550-nm Laser and Fractional Radiofrequency Microneedle for the Treatment of Acne Scars in Ethnic Skin Not yet recruiting NCT03380845 Not Applicable
42 Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin Completed NCT00875381
43 VELOS for the Treatment of Vascular Lesions and Skin Rejuvenation Recruiting NCT02468453 Not Applicable
44 Study of Families With Melanoma Recruiting NCT00445783
45 French Clinical Datbase of Melanoma Patients (RIC-Mel) Recruiting NCT03315468
46 Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome Recruiting NCT03806075 Not Applicable
47 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
48 Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer Recruiting NCT03030404
49 Pancreatic Cancer Screening of High-Risk Individuals in Arkansas Active, not recruiting NCT02309632 Not Applicable
50 Pancreatic Cancer Early Detection Program Recruiting NCT02206360

Search NIH Clinical Center for Lentigines

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Genetic Tests for Lentigines

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Anatomical Context for Lentigines

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MalaCards organs/tissues related to Lentigines:

41
Skin, Cortex, Bone, Pituitary, Thyroid, Adrenal Gland, Adrenal Cortex
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Publications for Lentigines

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Articles related to Lentigines:

(show top 50) (show all 618)
# Title Authors Year
1
Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. ( 29948457 )
2018
2
Multiple Lentigines Arising in Sites of Resolving Psoriatic Plaques after Treatment with Ustekinumab. ( 29853759 )
2018
3
A prospective, randomized, double-blinded, split-face pilot study comparing Q-switched 1064-nm Nd:YAG versus 532-nm Nd:YAG laser for the treatment of solar lentigines. ( 29482397 )
2018
4
Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. ( 29923175 )
2018
5
Multiple lentigines arising on resolving psoriatic plaques after treatment with apremilast. ( 29926507 )
2018
6
Noonan syndrome with multiple lentigines and associated craniosynostosis. ( 29356064 )
2018
7
Removal of forearm lentigines in dyschromatosis universalis hereditaria with a 755-nm Q-switched alexandrite laser. ( 29379862 )
2018
8
Prospective study of removing solar lentigines in Asians using a novel dual-wavelength and dual-pulse width picosecond laser. ( 29608215 )
2018
9
Pigmented actinic lichen planus (PALP) mimicking lentigo maligna melanoma: Usefulness of in vivo reflectance confocal microscopy in diagnosis and follow-up. ( 29998176 )
2018
10
Importance of cardiovascular examination in patients with multiple lentigines: two cases of LEOPARD syndrome with hypertrophic cardiomyopathy. ( 29717636 )
2018
11
Widespread keratosis pilaris in a patient with Noonan syndrome with multiple lentigines. ( 30152106 )
2018
12
Treatment of solar lentigines using a combination of picosecond laser and biophotonic treatment. ( 30214780 )
2018
13
Lentigines Formation in Caucasian Women - Interaction Between Particulate Matter and Solar Ultraviolet Radiation. ( 30404022 )
2018
14
Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour. ( 28685596 )
2018
15
Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream. ( 30065586 )
2018
16
Serial excision and Imiquimod for lentigo maligna melanoma: a proposal for a combined treatment. ( 30251811 )
2018
17
The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management. ( 30302753 )
2018
18
Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia. ( 30548854 )
2018
19
Protection against summer solar lentigo over-pigmentation with a SPF30 daily cream. ( 29446160 )
2018
20
Comparison of Melanocyte Density Counts in Topical Imiquimod-Treated Skin Surrounding Lentigo Maligna vs Control Biopsy Specimens. ( 29453870 )
2018
21
Intradermal tranexamic acid injections to prevent post-inflammatory hyperpigmentation after solar lentigo removal with a Q-switched 532-nm Nd:YAG laser. ( 29505310 )
2018
22
Treatment for Lentigo Maligna of the Head and Neck: Survey of Practices in Ontario, Canada. ( 29543619 )
2018
23
In vivo reflectance confocal microscopy combined with the 'spaghetti technique' for the identification of surgical margins of lentigo maligna: experience in 70 patients. ( 29573292 )
2018
24
Lentigo maligna: diagnosis and treatment. ( 29683288 )
2018
25
Bedside diagnosis of lentigo maligna with reflectance confocal microscopy. ( 29693252 )
2018
26
The smart approach: feasibility of lentigo maligna superficial margin assessment with hand-held reflectance confocal microscopy technology. ( 29704275 )
2018
27
Rate of Recurrence of Lentigo Maligna Treated With Off-Label Neoadjuvant Topical Imiquimod, 5%, Cream Prior to Conservatively Staged Excision. ( 29847610 )
2018
28
Lentigo Maligna-Challenges, Observations, Imiquimod, Confocal Microscopy, and Personalized Treatment. ( 29847677 )
2018
29
Lentigo Maligna - Not Always a Face and Neck Disease of the Elderly. ( 29895005 )
2018
30
Treating melanoma in situ and lentigo maligna with Mohs micrographic surgery in Australia. ( 29932208 )
2018
31
Reflectance Confocal Microscopic and En Face Histopathologic Correlation of the Dermoscopic "Circle Within a Circle" in Lentigo Maligna. ( 30046812 )
2018
32
Experience with Treating Lentigo Maligna with Definitive Radiotherapy. ( 30105052 )
2018
33
Dermatoscopy of flat pigmented facial lesions-evolution of lentigo maligna diagnostic criteria. ( 30116664 )
2018
34
3D microvascular analysis reveals irregularly branching blood vessels in the hyperpigmented skin of solar lentigo. ( 30117278 )
2018
35
Locally recurrent lentigo maligna within a skin graft: a case report. ( 30203614 )
2018
36
Dermoscopy findings of a one mm lentigo maligna. ( 30261577 )
2018
37
Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin. ( 30264463 )
2018
38
Follicular Involvement is Frequent in Lentigo Maligna: Implications for Treatment. ( 30266559 )
2018
39
Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo. ( 30279727 )
2018
40
Imiquimod 5% cream in occlusion, for the treatment of lentigo maligna: A new scheme of short cycles and the need for clinical trials. ( 30285299 )
2018
41
Gender differences, UV exposure and risk of lentigo maligna in a nationwide healthcare population cohort study. ( 30451319 )
2018
42
Confocal Microscopy and Lentigo Maligna: An in vivo Pilot Study for the Assessment of Response to Imiquimod Therapy. ( 30554198 )
2018
43
Lymphoedema in patients with lentigo maligna treated with imiquimod: a long-term adverse effect. ( 29274234 )
2018
44
An unusual early onset of lentigo maligna in the fourth decade of life. ( 29327697 )
2018
45
Dermoscopy vs. reflectance confocal microscopy for the diagnosis of lentigo maligna. ( 29341263 )
2018
46
Lentigo vaginae (vaginal melanosis). ( 29385866 )
2018
47
Variation in the diagnosis and clinical management of lentigo maligna across Europe: a survey study among European Association of Dermatologists and Venereologists members. ( 29419913 )
2018
48
A Novel De novo Mutation of the SASH1 Gene in a Chinese Family with Multiple Lentigines. ( 27840890 )
2017
49
Postinflammatory hyperpigmentation associated with treatment of solar lentigines using a Q-Switched 532-nm Nd: YAG laser: a multicenter survey. ( 27786580 )
2017
50
Familial gastrointestinal stromal tumors, lentigines, and cafAc-au-lait macules associated with germline c-kit mutation treated with imatinib. ( 28074523 )
2017
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Variations for Lentigines

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Expression for Lentigines

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Search GEO for disease gene expression data for Lentigines.
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Pathways for Lentigines

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Pathways related to Lentigines according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Sertoli-Sertoli Cell Junction Dynamics 64
Show member pathways
 12.66 BRAF PRKAR1A RAF1
2
CCR5 Pathway in Macrophages 64
Show member pathways
 12.63 BRAF PRKAR1A RAF1
3
Endometrial cancer 37
Show member pathways
 12.61 BRAF PTPN11 RAF1
4
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.6 BRAF PRKAR1A RAF1
5
Beta-Adrenergic Signaling 64
Show member pathways
 12.55 BRAF PRKAR1A RAF1
6
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.52 BRAF PTPN11 RAF1
7
Ras signaling pathway 37
Show member pathways
 12.46 BRAF PTPN11 RAF1
8
Development HGF signaling pathway 22
Show member pathways
 12.45 BRAF PTPN11 RAF1
9
G-AlphaQ Signaling 64
Show member pathways
 12.4 BRAF PRKAR1A RAF1
10
Neuropathic Pain-Signaling in Dorsal Horn Neurons 64
Show member pathways
 12.39 BRAF PRKAR1A RAF1
11
Development Dopamine D2 receptor transactivation of EGFR 22
Show member pathways
 12.29 PRKAR1A PTPN11 RAF1
12
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.22 BRAF PTPN11 RAF1
13
ErbB signaling pathway 1 37
Show member pathways
 12.16 BRAF PTPN11 RAF1
14
Cushing syndrome 37
Show member pathways
 12.06 BRAF MC1R RAF1
15
Regulation of lipid metabolism Insulin signaling-generic cascades 22
Show member pathways
 12.03 BRAF PRKAR1A PTPN11 RAF1
16
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.02 BRAF PTPN11 RAF1
17
B cell receptor signaling pathway (KEGG) 37
Show member pathways
 11.98 BRAF PTPN11 RAF1
18
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.97 BRAF PRKAR1A RAF1
19
G-protein signaling G-Protein alpha-i signaling cascades 22
Show member pathways
 11.95 BRAF PRKAR1A RAF1
20
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 11.8 BRAF PTPN11 RAF1
21
Proteoglycans in cancer 37
11.8 BRAF PTPN11 RAF1
22
Glioblastoma Multiforme 64
11.76 BRAF RAF1
23
Parathyroid hormone synthesis, secretion and action 37
11.74 BRAF RAF1
24
Senescence and Autophagy in Cancer 1
11.74 BRAF RAF1
25
ErbB1 downstream signaling 1
11.72 BRAF RAF1
26
Development EPO-induced Jak-STAT pathway 22
Show member pathways
 11.69 PTPN11 RAF1
27
TGF-beta Signaling Pathways 65
11.69 BRAF RAF1
28
Corticotropin-releasing hormone signaling pathway 1
11.67 BRAF RAF1
29
EGF/EGFR Signaling Pathway 1
11.65 BRAF PTPN11 RAF1
30
VEGF Pathway (Tocris) 61
Show member pathways
 11.6 BRAF RAF1
31
Bladder cancer 37 1
11.54 BRAF RAF1
32
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.51 BRAF RAF1
33
Development EGFR signaling via small GTPases 22
Show member pathways
 11.51 PRKAR1A PTPN11 RAF1
34
Negative regulation of MAPK pathway 66
Show member pathways
 11.48 BRAF RAF1
35
G-protein signaling TC21 regulation pathway 22
Show member pathways
 11.44 BRAF RAF1
36
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.44 BRAF RAF1
37
mTOR signaling pathway (Pathway Interaction Database) 1
11.44 BRAF RAF1
38
G-protein signaling_RhoA regulation pathway 22
11.44 BRAF PRKAR1A RAF1
39
Long-term depression 37
11.43 BRAF RAF1
40
Signaling events mediated by focal adhesion kinase 1
11.37 BRAF RAF1
41
G-protein signaling_Rap1A regulation pathway 22
11.33 BRAF RAF1
42
Semaphorin Signaling 64
11.32 BRAF RAF1
43
Immune response_Role of integrins in NK cells cytotoxicity 22
11.26 PTPN11 RAF1
44
Interleukin-11 Signaling Pathway 1
11.25 PTPN11 RAF1
45
Vemurafenib Pathway, Pharmacodynamics 61
11.23 BRAF RAF1
46
Melanocyte Development and Pigmentation 64
11.21 MC1R PRKAR1A
47
Immune response_IL-6 signaling pathway 22
11.1 PTPN11 RAF1
48
Trk receptor signaling mediated by the MAPK pathway 1
Show member pathways
 11.05 BRAF RAF1
49
G-protein signaling_Cross-talk between Ras-family GTPases 22
11.05 BRAF PRKAR1A RAF1
50
Telomere Extension by Telomerase 64
Show member pathways
 11.02 PTPN11 RAF1
Sources

GO Terms for Lentigines

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Biological processes related to Lentigines according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.67 BRAF PRKAR1A RAF1
2 platelet activation GO:0030168 9.48 PTPN11 RAF1
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.46 BRAF RAF1
4 somatic stem cell population maintenance GO:0035019 9.43 BRAF RAF1
5 heart development GO:0007507 9.43 PRKAR1A PTPN11 RAF1
6 activation of MAPKK activity GO:0000186 9.4 BRAF RAF1
7 thymus development GO:0048538 9.37 BRAF RAF1
8 thyroid gland development GO:0030878 9.32 BRAF RAF1
9 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 PTPN11 RAF1
10 face development GO:0060324 8.96 BRAF RAF1
11 intracellular signal transduction GO:0035556 8.92 BRAF MC1R PRKAR1A RAF1

Molecular functions related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.43 BRAF PRKAR1A RAF1
2 MAP kinase kinase kinase activity GO:0004709 9.16 BRAF RAF1
3 small GTPase binding GO:0031267 8.96 BRAF RAF1
4 mitogen-activated protein kinase kinase binding GO:0031434 8.62 BRAF RAF1
Sources

Sources for Lentigines

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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