MCID: LNT004
MIFTS: 48

Lentigines

Categories: Skin diseases
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Aliases & Classifications for Lentigines

MalaCards integrated aliases for Lentigines:

Name: Lentigines 57 53 75
Lentigo 71 75

Characteristics:


Inheritance:

Autosomal dominant 57

Classifications:



External Ids:

OMIM® 57 150900
MedGen 40 C0023321
SNOMED-CT via HPO 69 199879009 563001 95320005
UMLS 71 C0023321

Summaries for Lentigines

MalaCards based summary: Lentigines, also known as lentigo, is related to noonan syndrome with multiple lentigines and hyperpigmentation with or without hypopigmentation, familial progressive. An important gene associated with Lentigines is PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha), and among its related pathways/superpathways are Disease and Signal Transduction. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and heart, and related phenotypes are nystagmus and abnormality of the skin

Wikipedia: 75 A lentigo (/lɛnˈtaɪɡoʊ/) (plural lentigines, /lɛnˈtɪdʒɪniːz/) is a small pigmented spot on the skin with... more...

More information from OMIM: 150900

Related Diseases for Lentigines

Diseases related to Lentigines via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 noonan syndrome with multiple lentigines 33.1 RAF1 PTPN11 BRAF
2 hyperpigmentation with or without hypopigmentation, familial progressive 31.4 KITLG KIT
3 peutz-jeghers syndrome 30.5 STK11 PRKAR1A CNC2
4 pseudo-turner syndrome 30.4 RAF1 PTPN11 BRAF
5 rasopathy 30.3 RAF1 PTPN11 KIT BRAF
6 nodular malignant melanoma 30.3 TYR MC1R KIT BRAF
7 malignant spindle cell melanoma 30.3 TYR KIT
8 amelanotic melanoma 30.2 TYR MC1R KIT
9 vitiligo-associated multiple autoimmune disease susceptibility 1 30.0 TYR MC1R KITLG
10 melanoma in congenital melanocytic nevus 29.9 TYR RAF1 MC1R KIT BRAF
11 mucosal melanoma 29.9 TYR KIT BRAF
12 pulmonic stenosis 29.9 RAF1 PTPN11 BRAF
13 skin melanoma 29.9 TYR RAF1 MC1R KIT BRAF
14 cardiofaciocutaneous syndrome 1 29.9 RAF1 PTPN11 BRAF
15 gastrointestinal stromal tumor 29.9 RAF1 KITLG KIT BRAF
16 acral lentiginous melanoma 29.9 TYR MC1R KIT BRAF
17 neurilemmoma 29.8 TYR PRKAR1A KIT CNC2
18 skin carcinoma 29.7 TYR MSH2 MC1R KIT
19 ocular melanoma 29.7 TYR MC1R KIT
20 conn's syndrome 29.6 PRKAR1A EDN1 CNC2 BRAF
21 neurofibroma 29.5 TYR KITLG KIT
22 testicular germ cell tumor 29.5 STK11 KITLG KIT
23 adenoma 29.4 PRKAR1A MSH2 MLH1 BRAF
24 merkel cell carcinoma 29.4 RAF1 KITLG KIT BRAF
25 microphthalmia 29.3 TYR MC1R KIT BRAF
26 lynch syndrome 29.2 STK11 MSH2 MLH1 BRAF
27 testicular cancer 29.2 TYR STK11 KITLG KIT
28 dysplastic nevus syndrome 29.2 STK11 MSH2 MLH1 MC1R
29 leukemia, chronic myeloid 29.2 RAF1 PTPN11 KITLG KIT BRAF
30 cowden syndrome 1 29.1 STK11 PRKAR1A MSH2 MLH1
31 cowden syndrome 29.1 STK11 PRKAR1A MSH2 MLH1 CNC2
32 basal cell carcinoma 29.1 TYR MSH2 MLH1 MC1R
33 neurofibromatosis 29.0 PTPN11 MSH2 MLH1 KITLG KIT BRAF
34 neurofibromatosis, type i 29.0 RAF1 PTPN11 MSH2 MLH1 KITLG KIT
35 waardenburg's syndrome 29.0 TYR MC1R KITLG KIT EDNRB
36 melanoma 28.7 TYR STK11 RAF1 MLH1 MC1R KITLG
37 dowling-degos disease 1 28.6 TYR STK11 KITLG KIT EDN1
38 melanoma, cutaneous malignant 1 27.7 TYR STK11 RAF1 MSH2 MLH1 MC1R
39 lentigo maligna melanoma 11.7
40 leopard syndrome 1 11.5
41 gastrocutaneous syndrome 11.4
42 leopard syndrome 2 11.4
43 lentiginosis, inherited patterned 11.3
44 leopard syndrome 3 11.3
45 carney complex variant 11.3
46 noonan syndrome 1 11.2
47 melanocytic nevus syndrome, congenital 11.1
48 spastic paraplegia 23, autosomal recessive 11.0
49 uv-sensitive syndrome 11.0
50 dyschromatosis universalis hereditaria 1 10.9

Graphical network of the top 20 diseases related to Lentigines:



Diseases related to Lentigines

Symptoms & Phenotypes for Lentigines

Human phenotypes related to Lentigines:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nystagmus 30 HP:0000639
2 abnormality of the skin 30 HP:0000951

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Eyes:
nystagmus

Skin:
lentigines

Clinical features from OMIM®:

150900 (Updated 08-Dec-2022)

GenomeRNAi Phenotypes related to Lentigines according to GeneCards Suite gene sharing:

25 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.77 BRAF
2 Decreased viability GR00055-A-2 9.77 BRAF
3 Decreased viability GR00221-A-1 9.77 KIT RAF1
4 Decreased viability GR00221-A-2 9.77 RAF1
5 Decreased viability GR00221-A-4 9.77 BRAF
6 Decreased viability GR00249-S 9.77 BRAF
7 Decreased viability GR00301-A 9.77 BRAF KIT MSH2 RAF1
8 Decreased viability GR00381-A-1 9.77 BRAF
9 Decreased viability GR00402-S-2 9.77 RAF1
10 Decreased substrate adherent cell growth GR00193-A-1 9.17 KIT RAF1 STK11
11 Decreased substrate adherent cell growth GR00193-A-2 9.17 KIT RAF1
12 Decreased substrate adherent cell growth GR00193-A-3 9.17 STK11
13 Decreased substrate adherent cell growth GR00193-A-4 9.17 KIT

MGI Mouse Phenotypes related to Lentigines:

45 (show all 25)
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 10.4 BRAF EDNRB KIT KITLG MC1R MLH1
2 homeostasis/metabolism MP:0005376 10.34 BRAF EDN1 EDNRB KIT KITLG MLH1
3 growth/size/body region MP:0005378 10.31 BRAF EDN1 EDNRB KIT KITLG MC1R
4 nervous system MP:0003631 10.3 BRAF EDN1 EDNRB KIT KITLG MSH2
5 endocrine/exocrine gland MP:0005379 10.26 BRAF EDN1 EDNRB KIT KITLG MLH1
6 cellular MP:0005384 10.23 BRAF EDNRB KIT KITLG MC1R MLH1
7 pigmentation MP:0001186 10.22 BRAF EDNRB KIT KITLG MC1R PRKAR1A
8 craniofacial MP:0005382 10.22 BRAF EDN1 EDNRB KIT KITLG MC1R
9 normal MP:0002873 10.21 BRAF EDN1 KIT PRKAR1A PTPN11 RAF1
10 embryo MP:0005380 10.21 BRAF EDN1 EDNRB KIT KITLG PRKAR1A
11 hearing/vestibular/ear MP:0005377 10.2 BRAF EDN1 EDNRB KIT KITLG MC1R
12 muscle MP:0005369 10.19 BRAF EDN1 EDNRB KIT PRKAR1A PTPN11
13 digestive/alimentary MP:0005381 10.19 BRAF EDN1 EDNRB KIT KITLG MLH1
14 limbs/digits/tail MP:0005371 10.17 BRAF EDNRB KIT KITLG MC1R PRKAR1A
15 renal/urinary system MP:0005367 10.14 BRAF EDN1 EDNRB KIT PRKAR1A STK11
16 immune system MP:0005387 10.14 BRAF EDNRB KIT KITLG MLH1 MSH2
17 cardiovascular system MP:0005385 10.13 BRAF EDN1 EDNRB KIT KITLG PRKAR1A
18 liver/biliary system MP:0005370 10.12 BRAF KIT KITLG PRKAR1A PTPN11 RAF1
19 no phenotypic analysis MP:0003012 10.08 KIT MC1R PTPN11 RAF1 STK11 TYR
20 skeleton MP:0005390 10.02 BRAF EDN1 EDNRB KIT KITLG PRKAR1A
21 respiratory system MP:0005388 9.97 BRAF EDNRB KIT MLH1 PRKAR1A PTPN11
22 vision/eye MP:0005391 9.91 BRAF EDNRB KIT KITLG PRKAR1A PTPN11
23 hematopoietic system MP:0005397 9.85 BRAF EDNRB KIT KITLG MLH1 MSH2
24 mortality/aging MP:0010768 9.73 BRAF EDN1 EDNRB KIT KITLG MLH1
25 integument MP:0010771 9.4 BRAF EDNRB KIT KITLG MC1R MLH1

Drugs & Therapeutics for Lentigines

Drugs for Lentigines (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4 106-60-5 137
2
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
3
Glycolic acid Approved, Investigational Phase 4 79-14-1 757
4 Photosensitizing Agents Phase 4
5 Adjuvants, Immunologic Phase 4
6 interferons Phase 4
7 Immunologic Factors Phase 4
8 Keratolytic Agents Phase 4
9
Fluocinolone acetonide Approved, Investigational, Vet_approved Phase 2 67-73-2 6215
10
Hydroquinone Approved, Investigational Phase 2 123-31-9 785
11
Isotretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4, 4759-48-2 5538 444795 5282379
12
Cediranib Investigational Phase 2 288383-20-0 9933475
13
Maleic acid Experimental, Investigational Phase 2 110-16-7, 110-17-8 444266 444972
14 Protein Kinase Inhibitors Phase 2
15 R04929097 Phase 2
16
Clobetasol Approved, Experimental, Investigational 25122-46-7, 25122-41-2 2791 5311051 32798
17
Framycetin Approved, Experimental, Vet_approved 1404-04-2, 119-04-0, 3947-65-7 413349 8378
18
Petrolatum Approved, Investigational 8009-03-8
19
Tazarotene Approved, Investigational 118292-40-3 5381
20
Lidocaine Approved, Vet_approved 137-58-6 3676
21
Prilocaine Approved 721-50-6 4906
22
Tetracaine Approved, Vet_approved 94-24-6 5411
23
Chlorhexidine Approved, Vet_approved, Withdrawn 55-56-1 2713 9552079
24 Hormones
25 Hormone Antagonists
26 glucocorticoids
27 Anti-Inflammatory Agents
28 Anti-Bacterial Agents
29 Antibiotics, Antitubercular
30 Sunscreening Agents
31 Emollients
32 Mitogens
33 Anti-Arrhythmia Agents
34 Sodium Channel Blockers
35 Anesthetics, Local
36 Anesthetics
37 Diuretics, Potassium Sparing
38 Chlorhexidine gluconate
39 Dermatologic Agents

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Photodynamic Therapy for Melanoma Precursor Lesion Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion (BF-200 ALA) as a Light Sensitizing Cream Completed NCT02685592 Phase 4 5-aminolevulinic acid nanoemulsion
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Use of TCA 15% + 3% Glycolic Acid Chemical Peel for Improvement in Hand Lentigines Not yet recruiting NCT05471947 Phase 4 15% Trichloroacetic acid + 3% glycolic acid
4 An Open Monocentric Pilot Study to Investigate the Potential of Imiquimod 5% Cream to Detect Residual and to Prevent Recurrence of Lentigo Maligna After Surgical Excision Unknown status NCT01088737 Phase 2, Phase 3 Imiquimod
5 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Completed NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
6 A Randomised Controlled Multicentre Trial of Imiquimod Versus Radiotherapy for Lentigo Maligna (LM) When Staged Surgical Excision With 5mm Margins is Not Possible, is Refused, or Fails Active, not recruiting NCT02394132 Phase 3 Imiquimod
7 Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face - Study PICAMEL Unknown status NCT02723721 Phase 2 Picato gel
8 Efficacy and Side Effects of Q-Switched Ruby Laser Treatment of Solar Lentigines in Two Different Fitzpatrick Skin Types II and IV Completed NCT00386204 Phase 2
9 Solar Lentigines Treatment With the Triple Combination Cream (Hydroquinone 4%, Tretinoin 0.05%, and Fluocinolone Acetonide 0.01%). Randomized, Double Blind, Controlled Trial. Completed NCT00975312 Phase 2 Triple combination cream;Tretinoin 0.05%
10 A Phase II Study of AZD2171 in Previously Untreated Patients With Metastatic or Recurrent Malignant Melanoma Completed NCT00243061 Phase 2 cediranib maleate
11 A Phase II Trial of SCH 727965 (NSC 747135) in Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
12 Phase II Study of RO4929097 (NSC-749225) in Advanced Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
13 Evaluate the Lightening Effect of the Whitening Cosmetic Product BEX-2011 on Solar Lentigines by Harmonic Generation Microscopy Unknown status NCT01249469
14 Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder Unknown status NCT03578315
15 Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion. Unknown status NCT01136629
16 Safety and Efficacy of Cutera Picosecond Q-Switched Nd:YAG Laser in the Treatment of Solar Lentigines Completed NCT01885871
17 A Single Center, Randomized, Double-blind and Placebo Controlled Clinical Study to Evaluate the Efficacy and Safety of Brightening Micro-needle Patch on Facial Solar Lentigines Completed NCT04583852
18 A Single-Center 2-Arm Study of the Enlighten and Excel V Laser for Lentigines on the Hands Completed NCT02763072
19 Study for the RevLite Laser System for Facial Solar Lentigines Completed NCT02110108
20 Effect of Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation Following Q-switched Nd:YAG 532 nm Laser for Treatment of Facial Lentigines - A Pilot Study Completed NCT02492373 topical 0.05% Clobetasol propionate ointment
21 A Prospective Multi-Center Study of a Novel Dual-Wavelength, Dual-Pulse Duration Laser for the Treatment of Melasma and Lentigines in Asian Skin Completed NCT02385994
22 Safety and Efficacy of a Triple Combination Cream as Adjuvant Treatment of Solar Lentigines With Cryotherapy. Completed NCT01778179 Tri-luma
23 Comparative Study Investigating the Therapy of of Solar Lentigines With the Q-switched SINON Rubin 694nm Laser Versus Pigmanorm® Cream Completed NCT02153697 Pigmanorm Cream
24 A Randomized Controlled Trial on the Effectiveness of Epidermal Growth Factor-containing Ointment on the Treatment of Solar Lentigines as Adjuvant Therapy Completed NCT04704245 epidermal growth factor (EGF)-containing ointment;Vehicle ointment
25 Prospective Clinical Trial to Assess the Performance of a Cyto-selective Cryotherapye "CRYOBEAUTY MAINS ET DECOLLETE" Compared With Liquid Nitrogen Cryotherapy in the Treatment of Solar Lentigines in 30 Patients Completed NCT03225729
26 Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna Completed NCT00707174 Imiquimod Cream;Tazarotene Cream 0.1%
27 Reflectance Confocal Microscopy to Diagnose Malignant Melanoma and Lentigo Maligna Completed NCT03508297
28 Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy Completed NCT03457246
29 In Vivo Reflectance Confocal Microscopy for Pigmented Lesion Diagnosis: A Multi-center Study Completed NCT00785369
30 Evaluation of the Tolerance of Cyto-selective Difluoroethane-based Cryotherapy Completed NCT05322668
31 Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers. Completed NCT03157427
32 Evaluation of the Tolerance and the Mode of Administration of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots Completed NCT05203263
33 Evaluation of the Tolerance and the Mode of Administration of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots Completed NCT05014321
34 Investigation Into the Natural History and Metabolic and Molecular Basis of RASopathies. Recruiting NCT04395495
35 The Effect of Topical Anesthetic Using Lidocaine 2.5%/Prilocaine 2.5% Versus Lidocaine 7%/Tetracaine 7% Cream on Patients' Pain and Operative Experience During Treatment With QSwitched 532nm Laser Active, not recruiting NCT02427724 lidocaine 2.5%/prilocaine 2.5% topical anesthetic;lidocaine 7%/tetracaine 7% topical anesthetic;placebo vehicle
36 Evaluation of the Tolerance and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) Not yet recruiting NCT05625815
37 MRB 0.3% Serum Effectiveness on 2 Early Clinical Markers of Photoinduced Cutaneous Aging: Actinic Lentigo and Actinic Keratosis A Single-center Clinical Study in Two Phases: First Phase: Randomized Double-blind Clinical Interventional Study Versus Placebo in Split Face or Split Skull Second Phase: Open-label Observational Clinical Study on the Entire Face or Skull Not yet recruiting NCT05152407
38 Evaluation of the Tolerance and Performance (Mode of Administration) of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots Not yet recruiting NCT05600049
39 Comparative Study of Electrical Impedance Spectroscopy (EIS) Models Against Verified Dermatological Diagnostic Data Suspended NCT04688749
40 Mohs Micrographic Surgery for Primary Cutaneous Malignant Melanoma In Situ Using Immunofluorescence Withdrawn NCT02306512

Search NIH Clinical Center for Lentigines

Genetic Tests for Lentigines

Anatomical Context for Lentigines

Organs/tissues related to Lentigines:

MalaCards : Skin, Pituitary, Heart, Cervix, Bone Marrow, Bone, Breast

Publications for Lentigines

Articles related to Lentigines:

(show top 50) (show all 1077)
# Title Authors PMID Year
1
A pedigree of generalized lentigo. 57
15422118 1950
2
A novel PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease and the Carney complex. 53 62
19833579 2010
3
PTPN11 gene mutation and severe neonatal hypertrophic cardiomyopathy: what is the link? 53 62
19582499 2009
4
Heterogeneity of skin manifestations in patients with Carney complex. 53 62
18804312 2008
5
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders. 53 62
18470943 2008
6
Polymorphism patterns in the promoter region of the MC1R gene are associated with development of freckles and solar lentigines. 53 62
18079748 2008
7
Effect of Val92Met and Arg163Gln variants of the MC1R gene on freckles and solar lentigines in Japanese. 53 62
17371441 2007
8
PTPN11 gene mutations: linking the Gln510Glu mutation to the "LEOPARD syndrome phenotype". 53 62
16733669 2006
9
Association between endothelin receptor B nonsynonymous variants and melanoma risk. 53 62
16145050 2005
10
A novel PTPN11 gene mutation bridges Noonan syndrome, multiple lentigines/LEOPARD syndrome and Noonan-like/multiple giant cell lesion syndrome. 53 62
15470362 2004
11
Clinical and molecular genetics of primary pigmented nodular adrenocortical disease. 53 62
15761532 2004
12
c-kit Mutation in generalized lentigines associated with gastrointestinal stromal tumor. 53 62
15118370 2004
13
Clinical and molecular genetics of Carney complex. 53 62
12666684 2003
14
PTPN11 mutations in LEOPARD syndrome. 53 62
12161596 2002
15
The melanocortin-1-receptor gene is the major freckle gene. 53 62
11487574 2001
16
Genetics of Peutz-Jeghers syndrome, Carney complex and other familial lentiginoses. 53 62
11595829 2000
17
Laser treatment of benign melanocytic lesion: a review. 62
36097230 2022
18
Risk assessment of occupational skin cancer among outdoor workers in southern Spain: local pilot study. 62
36424170 2022
19
Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome. 62
35568059 2022
20
Clinical overview on RASopathies. 62
36428239 2022
21
Prediction and association analyses of skin phenotypes in Japanese females using genetic, environmental, and physical features. 62
36437544 2022
22
Intense Pulsed Light on skin rejuvenation: a systematic review. 62
34609598 2022
23
Noonan Syndrome With Multiple Lentigines. 62
36273552 2022
24
Randomized, evaluator-blinded comparative study of a potassium titanyl phosphate (KTP) 532-nm picosecond laser and an alexandrite 755-nm picosecond laser for the treatment of solar lentigines in Asians. 62
35129875 2022
25
Eruptive lentigines confined to psoriatic plaques following biologic therapy. 62
35816253 2022
26
Treatment of facial pigmented disorders with a 785-nm picosecond Ti:sapphire laser in Asians: A report of three cases. 62
36214374 2022
27
Effects of Noonan Syndrome-Germline Mutations on Mitochondria and Energy Metabolism. 62
36231062 2022
28
Evaluation and characterization of facial skin aging using optical coherence tomography. 62
36208115 2022
29
Trigeminal Nerve Melanotic Schwannoma in Carney Complex. 62
36177281 2022
30
Facial skin characteristics and concerns in Indonesia: A cross-sectional observational study. 62
35785442 2022
31
S2k guideline: Laser therapy of the skin. 62
36098675 2022
32
HPV-29-associated multiple hyperpigmented plaques mimicking solar lentigines on the lower legs. 62
35429010 2022
33
Multimodality Imaging of LEOPARD Syndrome: Myocardial Hypertrophy With Diffuse Coronary Artery Dilation. 62
36062059 2022
34
Epilepsy in a cohort of children with Noonan syndrome and related disorders. 62
35575813 2022
35
A comprehensive study to explore tyrosinase inhibitory medicinal plants and respective phytochemicals for hyperpigmentation; molecular approach and future perspectives. 62
36017830 2022
36
Cognitive Phenotype and Psychopathology in Noonan Syndrome Spectrum Disorders through Various Ras/MAPK Pathway Associated Gene Variants. 62
36012976 2022
37
Frontal Fibrosing Alopecia and Sunscreen Use: A Cross-sectional Study of Actinic Damage. 62
35604235 2022
38
Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines. 62
33689087 2022
39
Actinic lentigines from Japanese and European volunteers share similar impaired biological functions. 62
35817661 2022
40
Laser therapy and light sources for labial lentigines in patients with Peutz-Jeghers syndrome. 62
35426222 2022
41
Impacts of skin disorders associated with facial discoloration on quality of life: Novel insights explaining discordance between life quality scores and willingness to pay. 62
34706154 2022
42
Neurological features of Noonan syndrome and related RASopathies: Pain and nerve enlargement characterized by nerve ultrasound. 62
35258168 2022
43
Risk of Skin Cancer with Phototherapy in Moderate-to-Severe Psoriasis: An Updated Systematic Review. 62
35783563 2022
44
Efficacy and safety of topical hydrogen peroxide 35% solution versus cryotherapy in the treatment of senile lentigo. 62
35723940 2022
45
Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression. 62
34532875 2022
46
RASopathies: Dermatologists' viewpoints. 62
35138057 2022
47
The Role of Er-yag Glass Laser in Skin Resurfacing. 62
34996116 2022
48
Targeting SHP2 phosphatase in hematological malignancies. 62
35503226 2022
49
Natural history of left ventricular hypertrophy in infants of diabetic mothers. 62
34968628 2022
50
[The clinical phenotype and gene analysis of syndromic deafness with PTPN11 gene mutation]. 62
35325944 2022

Variations for Lentigines

Expression for Lentigines

Search GEO for disease gene expression data for Lentigines.

Pathways for Lentigines

Pathways related to Lentigines according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.58 RAF1 PTPN11 PRKAR1A MSH2 MLH1 KITLG
2 13.37 STK11 RAF1 PTPN11 PRKAR1A MC1R KITLG
3
Show member pathways
13.18 RAF1 PTPN11 PRKAR1A KITLG KIT BRAF
4
Show member pathways
12.88 KIT KITLG PRKAR1A RAF1 STK11
5
Show member pathways
12.51 RAF1 MSH2 MLH1 KIT BRAF
6
Show member pathways
12.39 RAF1 KITLG KIT EDNRB EDN1 BRAF
7
Show member pathways
12.26 RAF1 PTPN11 KIT BRAF
8
Show member pathways
12.23 RAF1 KITLG KIT BRAF
9
Show member pathways
12.01 RAF1 PTPN11 PRKAR1A
10 12 PRKAR1A MSH2 MLH1 BRAF
11 11.98 STK11 MSH2 BRAF
12 11.94 STK11 RAF1 BRAF
13 11.91 RAF1 PTPN11 BRAF
14 11.83 RAF1 PTPN11 BRAF
15 11.82 KIT PTPN11 RAF1
16
Show member pathways
11.77 BRAF PRKAR1A PTPN11 RAF1
17
Show member pathways
11.75 PTPN11 KITLG KIT
18
Show member pathways
11.69 RAF1 PTPN11 KITLG KIT
19
Show member pathways
11.61 BRAF KIT RAF1
20 11.55 RAF1 PRKAR1A KITLG BRAF
21 11.49 RAF1 PTPN11 BRAF
22 11.14 RAF1 EDNRB EDN1
23 11.1 RAF1 EDNRB EDN1
24
Show member pathways
11.06 RAF1 PTPN11 EDN1
25
Show member pathways
11.02 RAF1 BRAF
26 10.97 RAF1 BRAF
27 10.61 RAF1 BRAF
28 10.54 PRKAR1A MC1R KITLG KIT
29 10.03 RAF1 KIT BRAF

GO Terms for Lentigines

Cellular components related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mismatch repair complex GO:0032300 8.8 MSH2 MLH1

Biological processes related to Lentigines according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 BRAF EDNRB KIT KITLG MC1R PTPN11
2 intracellular signal transduction GO:0035556 10.15 EDN1 EDNRB KIT MC1R PRKAR1A
3 positive regulation of MAP kinase activity GO:0043406 10.1 KITLG KIT EDN1
4 somatic stem cell population maintenance GO:0035019 9.99 RAF1 KIT BRAF
5 sensory perception of pain GO:0019233 9.97 EDN1 EDNRB MC1R
6 phosphorylation GO:0016310 9.96 STK11 RAF1 PRKAR1A KIT BRAF
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.95 RAF1 PTPN11
8 thymus development GO:0048538 9.95 TYR RAF1 BRAF
9 melanin biosynthetic process GO:0042438 9.94 TYR MC1R
10 positive regulation of renal sodium excretion GO:0035815 9.94 EDNRB EDN1
11 positive regulation of urine volume GO:0035810 9.93 EDNRB EDN1
12 renal sodium ion absorption GO:0070294 9.91 EDNRB EDN1
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.9 MSH2 MLH1
14 endothelin receptor signaling pathway GO:0086100 9.89 EDNRB EDN1
15 negative regulation of protein metabolic process GO:0051248 9.88 EDNRB EDN1
16 positive regulation of hormone secretion GO:0046887 9.87 PTPN11 EDN1
17 epithelial fluid transport GO:0042045 9.84 EDNRB EDN1
18 myeloid progenitor cell differentiation GO:0002318 9.83 KIT BRAF
19 developmental pigmentation GO:0048066 9.8 KIT EDNRB
20 positive regulation of isotype switching to IgA isotypes GO:0048298 9.76 MSH2 MLH1
21 negative regulation of hormone secretion GO:0046888 9.75 PTPN11 EDN1
22 vein smooth muscle contraction GO:0014826 9.73 EDN1 EDNRB
23 mast cell proliferation GO:0070662 9.67 KIT KITLG
24 thyroid gland development GO:0030878 9.63 RAF1 EDN1 BRAF
25 positive regulation of mast cell proliferation GO:0070668 9.62 KIT KITLG
26 regulation of biological quality GO:0065008 9.61 EDNRB EDN1
27 somatic recombination of immunoglobulin gene segments GO:0016447 9.58 MLH1 MSH2
28 melanocyte migration GO:0097324 9.56 KITLG KIT
29 pigmentation GO:0043473 9.17 TYR MC1R KIT EDNRB
30 somatic recombination of immunoglobulin genes involved in immune response GO:0002204 9.13 MSH2 MLH1

Molecular functions related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.55 STK11 RAF1 PRKAR1A KIT BRAF
2 nucleotide binding GO:0000166 9.5 STK11 RAF1 PRKAR1A MSH2 MLH1 KIT
3 mismatched DNA binding GO:0030983 9.43 MSH2 MLH1
4 guanine/thymine mispair binding GO:0032137 8.92 MSH2 MLH1

Sources for Lentigines

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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