Lentigines disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: LNT004 MIFTS: 51	Lentigines Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Lentigines

MalaCards integrated aliases for Lentigines:

Name: Lentigines ⁵⁸ ⁵⁶

Lentigo ⁷⁴

Characteristics:

OMIM:

⁵⁸

Inheritance:
autosomal dominant

HPO:

³³

lentigines:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁸ 150900

MedGen ⁴³ C0023321

SNOMED-CT via HPO ⁷⁰ 199879009 263681008 563001 more

UMLS ⁷⁴ C0023321

Sources

Summaries for Lentigines

MalaCards based summary : Lentigines, also known as lentigo, is related to noonan syndrome with multiple lentigines and melanocytic nevus syndrome, congenital. An important gene associated with Lentigines is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and CCR5 Pathway in Macrophages. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Affiliated tissues include skin, pituitary and pancreas, and related phenotypes are nystagmus and abnormality of the skin

Wikipedia : ⁷⁷ A lentigo (/lɛnˈtaɪɡoʊ/) (plural lentigines, /lɛnˈtɪdʒɪniːz/) is a small pigmented spot on the skin with... more...

Description from OMIM: 150900

Sources

Related Diseases for Lentigines

Diseases related to Lentigines via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)

#	Related Disease	Score	Top Affiliating Genes
1	noonan syndrome with multiple lentigines	33.5	BRAF PTPN11 RAF1
2	melanocytic nevus syndrome, congenital	32.3	MC1R PRKAR1A
3	leopard syndrome	32.1	BRAF PTPN11 RAF1
4	noonan syndrome 1	31.6	BRAF PTPN11 RAF1
5	hypertrophic cardiomyopathy	29.5	BRAF PTPN11 RAF1
6	hypertelorism	29.2	BRAF PTPN11 RAF1
7	acral lentiginous melanoma	12.7
8	leopard syndrome 1	12.0
9	gastrocutaneous syndrome	11.8
10	lentiginosis, inherited patterned	11.5
11	carney complex variant	11.4
12	phacomatosis pigmentokeratotica	11.4
13	dyschromatosis universalis hereditaria 1	11.4
14	phakomatosis pigmentokeratotica	11.4
15	uv-sensitive syndrome	11.2
16	nevoid hypermelanosis, linear and whorled	11.1
17	spastic paraplegia 23, autosomal recessive	11.0
18	legius syndrome	11.0
19	leopard syndrome 2	11.0
20	leopard syndrome 3	11.0
21	melanoma	10.9
22	pseudo-turner syndrome	10.4
23	neutrophil migration	10.2
24	melanoma in congenital melanocytic nevus	10.2
25	peutz-jeghers syndrome	10.2
26	psoriasis	10.2
27	mycosis fungoides	10.0
28	vitiligo-associated multiple autoimmune disease susceptibility 1	10.0
29	nodular malignant melanoma	10.0
30	sarcoma	10.0
31	neuropathy	10.0
32	tièche-jadassohn nevus	10.0
33	mastocytosis, cutaneous	9.9
34	neurofibromatosis, type i	9.9
35	neurofibromatosis, type iv, of riccardi	9.9
36	becker nevus syndrome	9.9
37	gastrointestinal stromal tumor	9.9
38	muscle hypertrophy	9.9
39	mucosal melanoma	9.9
40	dyschromatosis universalis hereditaria	9.9
41	urticaria	9.9
42	dermatitis	9.9
43	lipomatosis	9.9
44	skin carcinoma	9.9
45	pituitary adenoma	9.9
46	pustulosis of palm and sole	9.9
47	adenoma	9.9
48	muscular atrophy	9.9
49	rosacea	9.9
50	dermatophytosis	9.9

Graphical network of the top 20 diseases related to Lentigines:

Sources

Symptoms & Phenotypes for Lentigines

Human phenotypes related to Lentigines:

³³

#	Description	HPO Frequency	HPO Source Accession
1	nystagmus ³³		HP:0000639
2	abnormality of the skin ³³		HP:0000951

Symptoms via clinical synopsis from OMIM:

⁵⁸

Eyes:
nystagmus

Skin:
lentigines

Clinical features from OMIM:

150900

GenomeRNAi Phenotypes related to Lentigines according to GeneCards Suite gene sharing:

²⁷ (show all 21)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-110	9.7	BRAF
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.7	RAF1
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-118	9.7	PTPN11
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.7	PTPN11
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.7	PTPN11
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-149	9.7	BRAF PTPN11 RAF1
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.7	RAF1
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.7	RAF1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-166	9.7	BRAF
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.7	BRAF
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	9.7	PTPN11
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.7	PTPN11
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-194	9.7	BRAF
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-29	9.7	BRAF
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-31	9.7	BRAF
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.7	BRAF
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-37	9.7	PTPN11
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.7	BRAF PTPN11
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.7	RAF1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	9.7	PTPN11
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-78	9.7	PTPN11

MGI Mouse Phenotypes related to Lentigines:

⁴⁷ (show all 16)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.96	BRAF MC1R PRKAR1A PTPN11 RAF1
2	cellular	MP:0005384	9.95	BRAF MC1R PRKAR1A PTPN11 RAF1
3	craniofacial	MP:0005382	9.93	BRAF MC1R PRKAR1A PTPN11 RAF1
4	growth/size/body region	MP:0005378	9.91	BRAF MC1R PRKAR1A PTPN11 RAF1
5	hematopoietic system	MP:0005397	9.88	BRAF MC1R PRKAR1A PTPN11 RAF1
6	immune system	MP:0005387	9.85	BRAF MC1R PRKAR1A PTPN11 RAF1
7	embryo	MP:0005380	9.83	BRAF PRKAR1A PTPN11 RAF1
8	integument	MP:0010771	9.83	BRAF MC1R PRKAR1A PTPN11 RAF1
9	hearing/vestibular/ear	MP:0005377	9.8	BRAF MC1R PTPN11 RAF1
10	neoplasm	MP:0002006	9.72	BRAF MC1R PRKAR1A PTPN11 RAF1
11	liver/biliary system	MP:0005370	9.71	BRAF PRKAR1A PTPN11 RAF1
12	muscle	MP:0005369	9.67	BRAF PRKAR1A PTPN11 RAF1
13	normal	MP:0002873	9.56	BRAF PRKAR1A PTPN11 RAF1
14	pigmentation	MP:0001186	9.46	BRAF MC1R PRKAR1A PTPN11
15	respiratory system	MP:0005388	9.26	BRAF PRKAR1A PTPN11 RAF1
16	vision/eye	MP:0005391	8.92	BRAF PRKAR1A PTPN11 RAF1

Sources

Drugs & Therapeutics for Lentigines

Drugs for Lentigines (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Aminolevulinic acid

Approved

Phase 4,Phase 3

106-60-5

137

Imiquimod

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

99011-02-6

57469

Everolimus

Approved

Phase 4,Phase 2

159351-69-6

70789204 6442177

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2

22916-47-8

4189

Sirolimus

Approved, Investigational

Phase 4,Phase 2

53123-88-9

46835353 5284616 6436030

Dermatologic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Photosensitizing Agents

Phase 4,Phase 3

Immunologic Factors

Phase 4,Phase 3,Phase 2,Not Applicable

interferons

Phase 4,Phase 3,Phase 2,Not Applicable

Adjuvants, Immunologic

Phase 4,Phase 3,Phase 2,Not Applicable

Interferon Inducers

Phase 4,Phase 3,Phase 2,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 2

Antibiotics, Antitubercular

Phase 4,Phase 2,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 2,Not Applicable

Antifungal Agents

Phase 4,Phase 2

Anti-Infective Agents

Phase 4,Phase 2,Phase 1

Adapalene

Approved

Phase 3

106685-40-9

60164

Tretinoin

Approved, Investigational, Nutraceutical

Phase 3,Phase 2

302-79-4

444795 5538

Keratolytic Agents

Phase 3,Phase 2,Not Applicable

Anti-Inflammatory Agents, Non-Steroidal

Phase 3

Analgesics

Phase 3

Antirheumatic Agents

Phase 3

Anti-Inflammatory Agents

Phase 3,Phase 2,Not Applicable

Emollients

Phase 3

Analgesics, Non-Narcotic

Phase 3

Peripheral Nervous System Agents

Phase 3,Not Applicable

Methyl 5-aminolevulinate

Phase 3

Glycolic acid

Approved, Investigational

Phase 2

79-14-1

757

Fluocinolone Acetonide

Approved, Investigational, Vet_approved

Phase 2

67-73-2

6215

Hydroquinone

Approved, Investigational

Phase 2

123-31-9

785

Vitamin C

Approved, Nutraceutical

Phase 2

50-81-7

54670067 5785

Cediranib

Investigational

Phase 2

288383-20-0

9933475

Maleic acid

Experimental, Investigational

Phase 2

110-17-8, 110-16-7

444972

Antioxidants

Phase 2

Vitamins

Phase 2,Not Applicable

Nutrients

Phase 2,Not Applicable

Trace Elements

Phase 2,Not Applicable

Protective Agents

Phase 2

Micronutrients

Phase 2,Not Applicable

Hormones

Phase 2,Not Applicable

Radiation-Protective Agents

Phase 2

Hormone Antagonists

Phase 2,Not Applicable

glucocorticoids

Phase 2,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 2,Not Applicable

Protein Kinase Inhibitors

Phase 2

Ganciclovir

Approved, Investigational

Phase 1

82410-32-0

3454

Antiviral Agents

Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 1

Ganciclovir triphosphate

Phase 1

Neomycin

Approved, Vet_approved

Not Applicable

1404-04-2

8378

Interventional clinical trials:

(show top 50) (show all 55)

#	Name	Status	NCT ID	Phase	Drugs
1	Photodynamic Therapy for Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion as a Light Sensitizing Cream	Completed	NCT02685592	Phase 4	5-aminolevulinic acid nanoemulsion
2	Effect of Topical Imiquimod on Lentigo Maligna	Completed	NCT01161888	Phase 4	Imiquimod
3	Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome	Recruiting	NCT03781050	Phase 4	Rapamycin
4	Radiotherapy or Imiquimod in Complex Lentigo Maligna	Recruiting	NCT02394132	Phase 3	Imiquimod
5	Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face	Recruiting	NCT01720407	Phase 3	Imiquimod cream + surgery;Placebo + surgery
6	Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna	Active, not recruiting	NCT01088737	Phase 2, Phase 3	Imiquimod
7	Effectiveness and Safety of Isobutylamido-thiazolyl-resorcinol Cream 0.2% for Melasma and Facial Hyperpigmentation	Not yet recruiting	NCT03926845	Phase 3	Isobutylamido-thiazolyl-resorcinol Cream 0.2%;Vehicle
8	Clinical Study for the Evaluation of the Depigmenting Activity of a Cosmetic Product on Spotted Hand Skin	Completed	NCT02204436	Phase 3
9	Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage	Completed	NCT00647556	Phase 3	adapalene gel, 0.3%;tretinoin 0.05% emollient cream
10	Safety and Efficacy Study for the Treatment of Non-Aggressive Basal Cell Carcinoma With Photodynamic Therapy	Active, not recruiting	NCT02144077	Phase 3	BF-200 ALA;methyl-aminolevulinate
11	Short Incubation Methylaminolevulinate Photodynamic Therapy Without Occlusion	Completed	NCT00926952	Phase 3	Methylaminolevulinate (Metvix, Metvixia)
12	The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging	Unknown status	NCT02126644	Phase 2	70% glycolic acid
13	Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face	Recruiting	NCT02723721	Phase 2	Picato gel
14	Solar Lentigines Treatment With the Triple Combination Cream	Completed	NCT00975312	Phase 2	Triple combination cream;Tretinoin 0.05%
15	Side Effects of Q-Switched Ruby Laser for the Treatment of Lentigines in Light and Dark Skin Types	Completed	NCT00386204	Phase 2
16	Dinaciclib in Treating Patients With Stage IV Melanoma	Active, not recruiting	NCT00937937	Phase 2	Dinaciclib
17	Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma	Terminated	NCT01120275	Phase 2	gamma-secretase/Notch signalling pathway inhibitor RO4929097
18	AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma	Completed	NCT00243061	Phase 2	cediranib maleate
19	Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome	Withdrawn	NCT01178151	Phase 2	Everolimus
20	Pilot Study of mTOR Inhibitor Therapy in Peutz-Jeghers Syndrome	Terminated	NCT00811590	Phase 2	Everolimus
21	Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma	Completed	NCT00005057	Phase 1	ganciclovir
22	Evaluate the Lightening Effect of the Whitening Cosmetic Product BEX-2011	Unknown status	NCT01249469	Not Applicable
23	Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion	Unknown status	NCT01136629
24	Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes	Unknown status	NCT02486731
25	A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy	Completed	NCT01778179	Not Applicable	Tri-luma
26	Comparative Study of the Therapy of Solar Lentigines With a Q-switched Rubin Laser Versus a Bleaching Cream	Completed	NCT02153697	Not Applicable	Pigmanorm Cream
27	A Single-Center 2-Arm Study for Lentigines on the Hands	Completed	NCT02763072	Not Applicable
28	Assessment of CRYOBEAUTY MAINS ET DECOLLETE Versus Liquid Nitrogen Cryotherapy, in the Treatment of Solar Lentigines	Completed	NCT03225729	Not Applicable
29	Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder	Not yet recruiting	NCT03578315	Not Applicable
30	Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy	Completed	NCT03457246	Not Applicable
31	A Prospective Multi-Center Study Using Laser for the Treatment of Melasma and Lentigines in Asian Skin	Completed	NCT02385994	Not Applicable
32	Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna	Completed	NCT00707174	Not Applicable	Imiquimod Cream;Tazarotene Cream 0.1%
33	Study for the RevLite Laser System for Facial Solar Lentigines	Completed	NCT02110108	Not Applicable
34	Laser Removal of Age (Sun) Spots on Hands	Completed	NCT01885871	Not Applicable
35	Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers.	Completed	NCT03157427	Not Applicable
36	Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation After QsNdYAG Laser	Completed	NCT02492373	Not Applicable	topical 0.05% Clobetasol propionate ointment
37	The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser	Active, not recruiting	NCT02427724	Not Applicable	lidocaine 2.5%/prilocaine 2.5% topical anesthetic;lidocaine 7%/tetracaine 7% topical anesthetic;placebo vehicle
38	Reflectance Confocal Microscopy to Diagnose MM & LM	Recruiting	NCT03508297
39	Mohs and Immunofluorescence for Malignant Melanoma In Situ	Withdrawn	NCT02306512	Not Applicable
40	Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the CARNEY Complex (CNC)	Completed	NCT00668291
41	In Vivo Confocal Microscopy for Pigmented Lesion Diagnosis	Completed	NCT00785369	Not Applicable
42	Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex	Recruiting	NCT00001452
43	Comparison of 1,550-nm Laser and Fractional Radiofrequency Microneedle for the Treatment of Acne Scars in Ethnic Skin	Not yet recruiting	NCT03380845	Not Applicable
44	Analysis of Melanocytes (Pigment Cells) in Sun-Exposed Skin	Completed	NCT00875381
45	VELOS for the Treatment of Vascular Lesions and Skin Rejuvenation	Recruiting	NCT02468453	Not Applicable
46	Study of Families With Melanoma	Recruiting	NCT00445783
47	French Clinical Datbase of Melanoma Patients (RIC-Mel)	Recruiting	NCT03315468
48	Study of Accurate Diagnosis and Treatment of Peutz-Jeghers Syndrome	Recruiting	NCT03806075	Not Applicable
49	Familial Investigations of Childhood Cancer Predisposition	Recruiting	NCT03050268
50	Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer	Recruiting	NCT03030404

Search NIH Clinical Center for Lentigines

Sources

Genetic Tests for Lentigines

Sources

Anatomical Context for Lentigines

MalaCards organs/tissues related to Lentigines:

⁴²

Skin, Pituitary, Pancreas, Heart, Bone, Colon, Breast

Sources

Publications for Lentigines

Articles related to Lentigines:

(show top 50) (show all 818)

#	Title	Authors	Year
1	Lentigines within fixed drug eruption: reply to 'Multiple lentigines arising on resolving psoriatic plaques after treatment with apremilast'. ( 30575106 )	McCarthy S...Murphy M	2019
2	Importance of cardiovascular examination in patients with multiple lentigines: two cases of LEOPARD syndrome with hypertrophic cardiomyopathy. ( 29717636 )	Jurko T...Mestanik M	2019
3	A prospective study evaluating the effectiveness of Q-switched ND-YAG laser (KTP) in the treatment of solar lentigines with a skin analysis device. ( 30884014 )	Engin B...Serdaro?lu S	2019
4	UV irradiation-induced DNA hypomethylation around WNT1 gene: implications for solar lentigines. ( 31020703 )	Yamada T...Akamatsu H	2019
5	Multiple lentigines arising on resolving psoriatic plaques after treatment with apremilast. ( 29926507 )	Vazquez B...Monteagudo C	2019
6	Generation of an induced pluripotent stem cell line (TRNDi003-A) from a Noonan syndrome with multiple lentigines (NSML) patient carrying a p.Q510P mutation in the PTPN11 gene. ( 30640061 )	Li R...Zheng W	2019
7	Innumerable lentigines in a mother and daughter. ( 30675945 )	Cardis MA...Brownell I	2019
8	Efficacy and safety of intense pulsed light with a KTP filter for the treatment of solar lentigines. ( 30681160 )	Friedmann DP...Peterson JD	2019
9	Appearance of lentigines in psoriasis patient treated with guselkumab. ( 30710906 )	Lee EB...Wu JJ	2019
10	Keratinocytic Malfunction as a Trigger for the Development of Solar Lentigines. ( 30800656 )	Barysch MJ...Dummer R	2019
11	Nine percent of biopsy proven lentigo maligna are reclassified as lentigo maligna melanoma after surgery. ( 30716164 )	Zoutendijk J...van den Bos RR	2019
12	Histologic predictors of invasion in partially biopsied lentigo maligna melanoma. ( 30879481 )	Aouidad I...Funck-Brentano E	2019
13	Estimated risk of progression of lentigo maligna to lentigo maligna melanoma. ( 31095041 )	Menzies SW...Guitera P	2019
14	The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management. ( 30302753 )	Guitera P...Cust AE	2019
15	Desmoplastic Melanoma Arising after 1,064 nm q-Switched Nd:YAG Laser of a Suspected Solar Lentigo. ( 31080677 )	Cohen L...Zaiac M	2019
16	Comparison of surgical margins for lentigo maligna versus melanoma in situ. ( 31014825 )	Kunishige JH...Zitelli JA	2019
17	Melanoma on Chronically Sun Damaged Skin: Lentigo Maligna and Desmoplastic Melanoma. ( 30930085 )	DeWane ME...Grant-Kels JM	2019
18	Treating melanoma in situ and lentigo maligna with Mohs micrographic surgery in Australia. ( 29932208 )	Foxton GC...Litterick KA	2019
19	The use of 2940-nm ER:YAG laser for the treatment of lentigo maligna. ( 30933436 )	Fikrle T...Pizinger K	2019
20	An unusual early onset of lentigo maligna in the fourth decade of life. ( 29327697 )	Platsidaki E...Agiasofitou E	2019
21	Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin. ( 30264463 )	Gambichler T...St?cker M	2019
22	Follicular involvement is frequent in lentigo maligna: Implications for treatment. ( 30266559 )	Connolly KL...Nehal K	2019
23	Imiquimod 5% cream in occlusion, for the treatment of lentigo maligna: A new scheme of short cycles and the need for clinical trials. ( 30285299 )	Astorino S...Paolino G	2019
24	Long-term outcomes of imiquimod-treated lentigo maligna. ( 30663131 )	Papanikolaou M...Lawrence CM	2019
25	Ten Years experience using the Johnson Square Procedure for Lentigo Maligna. ( 30762226 )	Smith H...Varma S	2019
26	Braf-V600e immunohistochemical analyses in a series of 15, Caucasian patients affected by lentigo maligna. ( 30797564 )	Dika E...Patrizi A	2019
27	Inadequacy of Recommended Margins in the Treatment of Lentigo Maligna. ( 30888947 )	Nanawati N...Langer PD	2019
28	Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: Evaluation of a series of 41 cases. ( 30997681 )	Gamo-Villegas R...L?pez-Estebaranz JL	2019
29	Unusual use of a common skin flap for a large cutaneous defect following Mohs surgery for lentigo maligna of the cheek: A case report. ( 31007926 )	Morand M...Nantel-Battista M	2019
30	Efficacy of D-pigment dermocosmetic lightening product for solar lentigo lesions of the hand: A randomized controlled trial. ( 31042723 )	Arginelli F...Pellacani G	2019
31	Histologic Features Associated With an Invasive Component in Lentigo Maligna Lesions. ( 31066867 )	Moreno A...Nagore E	2019
32	The integration of dermoscopy and reflectance confocal microscopy improves the diagnosis of lentigo maligna. ( 31074539 )	Cinotti E...Luc Perrot J	2019
33	A new dermoscopic algorithm for the differential diagnosis of facial lentigo maligna and pigmented actinic keratosis. ( 29620004 )	Micantonio T...Peris K	2018
34	Pigmented actinic lichen planus (PALP) mimicking lentigo maligna melanoma: Usefulness of in vivo reflectance confocal microscopy in diagnosis and follow-up. ( 29998176 )	Venturini M...Calzavara-Pinton P	2018
35	Widespread keratosis pilaris in a patient with Noonan syndrome with multiple lentigines. ( 30152106 )	Purnak S...Yal??n B	2018
36	Focal regression of a primary melanoma, fading lentigines and poliosis in metastatic melanoma treated with anti-PD-1. ( 29114959 )	Thomas S...Schaider H	2018
37	A prospective, randomized, double-blinded, split-face pilot study comparing Q-switched 1064-nm Nd:YAG versus 532-nm Nd:YAG laser for the treatment of solar lentigines. ( 29482397 )	Bohnert K...Sadick N	2018
38	Prospective study of removing solar lentigines in Asians using a novel dual-wavelength and dual-pulse width picosecond laser. ( 29608215 )	Negishi K...Matsunaga Y	2018
39	Multiple Lentigines Arising in Sites of Resolving Psoriatic Plaques after Treatment with Ustekinumab. ( 29853759 )	Kim JS...Lee JR	2018
40	Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. ( 29923175 )	Takeichi T...Akiyama M	2018
41	Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. ( 29948457 )	Vachiramon V...Triyangkulsri K	2018
42	Treatment of solar lentigines using a combination of picosecond laser and biophotonic treatment. ( 30214780 )	Scarcella G...Nielsen MCE	2018
43	Removal of forearm lentigines in dyschromatosis universalis hereditaria with a 755-nm Q-switched alexandrite laser. ( 29379862 )	Li Y...Li L	2018
44	Noonan syndrome with multiple lentigines and associated craniosynostosis. ( 29356064 )	McDonald BS...Batta K	2018
45	Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia. ( 30548854 )	Matas-Nadal C...Mart? RM	2018
46	Serial excision and Imiquimod for lentigo maligna melanoma: a proposal for a combined treatment. ( 30251811 )	Corneli P...Argenziano G	2018
47	Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream. ( 30065586 )	Kim NH...Yun SJ	2018
48	Staged margin-controlled excision (SMEX) for lentigo maligna melanoma in situ. ( 29936706 )	Beveridge J...Salopek TG	2018
49	Impact of Dermoscopy and Reflectance Confocal Microscopy on the Histopathologic Diagnosis of Lentigo Maligna/Lentigo Maligna Melanoma. ( 29933314 )	Mataca E...Cesinaro AM	2018
50	Repair of a Complex Marginal Auricular Defect After Lentigo Maligna Melanoma Excision. ( 29933298 )	Crisan D...Veit J	2018

Sources

Genes for Lentigines

Genes related to Lentigines (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	47.33	Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications Variants (show sections)	19582499 15470362 16733669 (more) 18470943 12161596
2	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	27.7	GeneCards inferred via : Disorders Variants (show sections)
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	27.6	GeneCards inferred via : Disorders Variants (show sections)
4	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	26.19	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19833579
5	MC1R	Melanocortin 1 Receptor	Protein Coding	23.21	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11487574 18079748 17371441

Sources

Variations for Lentigines

Sources

Expression for Lentigines

Search GEO for disease gene expression data for Lentigines.

Sources

Pathways for Lentigines

Pathways related to Lentigines according to GeneCards Suite gene sharing:

(show top 50) (show all 53)

#	Super pathways	Score	Top Affiliating Genes
1	Sertoli-Sertoli Cell Junction Dynamics ⁶⁵ Show member pathways Epithelial Tight Junctions ⁶⁵ Germ Cell-Sertoli Cell Junction Dynamics ⁶⁵	12.66	BRAF PRKAR1A RAF1
2	CCR5 Pathway in Macrophages ⁶⁵ Show member pathways Androgen Signaling ⁶⁵ Chemokine Signaling ⁶⁵ Chemokine signaling pathway ³⁸	12.62	BRAF PRKAR1A RAF1
3	NFAT and Cardiac Hypertrophy ⁶⁵ Show member pathways IGF1R Signaling ⁶⁵ Signaling Involved in Cardiac Hypertrophy ⁶⁵	12.6	BRAF PRKAR1A RAF1
4	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.6	BRAF PTPN11 RAF1
5	Beta-Adrenergic Signaling ⁶⁵ Show member pathways CDK5 Pathway ⁶⁵ Erythropoietin Pathway ⁶⁵ Insulin Receptor Pathway ⁶⁵	12.55	BRAF PRKAR1A RAF1
6	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁶ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁶ Development Thrombopoietin-regulated cell processes ²³ IL-15 Signaling Pathways ⁶⁶ IL-2 Signaling Pathways ⁶⁶ IL-21 Signaling Pathways ⁶⁶ IL-4 Signaling Pathways ⁶⁶ IL-7 Signaling Pathways ⁶⁶ IL-9 Pathway ⁶⁵ IL-9 Signaling Pathways ⁶⁶ Immune response IL-9 signaling pathway ²³	12.51	BRAF PTPN11 RAF1
7	Ras signaling pathway ³⁸ Show member pathways Rap1 signaling pathway ³⁸	12.46	BRAF PTPN11 RAF1
8	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁷ MET activates STAT3 ⁶⁷ Neurotrophin signaling pathway ³⁸ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.44	BRAF PTPN11 RAF1
9	G-AlphaQ Signaling ⁶⁵ Show member pathways G-AlphaI Signaling ⁶⁵ Thrombin Signaling ⁶⁵	12.39	BRAF PRKAR1A RAF1
10	Neuropathic Pain-Signaling in Dorsal Horn Neurons ⁶⁵ Show member pathways Aldosterone Signaling in Epithelial Cells ⁶⁵ Cholera Infection ⁶⁵	12.38	BRAF PRKAR1A RAF1
11	Development Dopamine D2 receptor transactivation of EGFR ²³ Show member pathways Apoptosis and survival BAD phosphorylation ²³ BAD Phosphorylation ⁶⁵ Chemotaxis CXCR4 signaling pathway ²³ Development Alpha-2 adrenergic receptor activation of ERK ²³	12.28	PRKAR1A PTPN11 RAF1
12	ErbB signaling pathway ¹ ³⁸ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶² EGFR tyrosine kinase inhibitor resistance ³⁸ Renal cell carcinoma ³⁸ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.26	BRAF PTPN11 RAF1
13	Immune response Role of DAP12 receptors in NK cells ²³ Show member pathways Immune response CD16 signaling in NK cells ²³ Natural killer cell mediated cytotoxicity ³⁸	12.21	BRAF PTPN11 RAF1
14	Regulation of lipid metabolism Insulin signaling-generic cascades ²³ Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²³ Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²³ Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²³ ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁸ IRS activation ⁶⁷ Signal attenuation ⁶⁷ Transcription Receptor-mediated HIF regulation ²³ Translation Regulation of EIF2 activity ²³ Translation Regulation of EIF4F activity ²³ Translation Insulin regulation of translation ²³	12.03	BRAF PRKAR1A PTPN11 RAF1
15	Development VEGF signaling via VEGFR2 - generic cascades ²³ Show member pathways Development VEGF signaling and activation ²³ VEGF - VEGF R2 Signaling Pathways ⁶⁶	12.02	BRAF PTPN11 RAF1
16	B cell receptor signaling pathway (KEGG) ³⁸ Show member pathways B Cell Receptor Signaling Pathway ¹ BCR signaling pathway ¹	11.98	BRAF PTPN11 RAF1
17	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²³ Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²³	11.96	BRAF PRKAR1A RAF1
18	G-protein signaling G-Protein alpha-i signaling cascades ²³ Show member pathways Development Beta-adrenergic receptors regulation of ERK ²³ G-protein signaling G-Protein alpha-s signaling cascades ²³ G-protein signaling G-Protein beta/gamma signaling cascades ²³	11.95	BRAF PRKAR1A RAF1
19	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²³ Show member pathways Activation of the AP-1 family of transcription factors ⁶⁷ Immune response Oncostatin M signaling via MAPK in human cells ²³ MAPK Cascade ¹ Oncostatin M Signaling Pathway ¹	11.8	BRAF PTPN11 RAF1
20	Proteoglycans in cancer ³⁸	11.8	BRAF PTPN11 RAF1
21	Glioblastoma Multiforme ⁶⁵	11.76	BRAF RAF1
22	Parathyroid hormone synthesis, secretion and action ³⁸	11.74	BRAF RAF1
23	Senescence and Autophagy in Cancer ¹	11.73	BRAF RAF1
24	ErbB1 downstream signaling ¹	11.72	BRAF RAF1
25	Development EPO-induced Jak-STAT pathway ²³ Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.69	PTPN11 RAF1
26	TGF-beta Signaling Pathways ⁶⁶	11.68	BRAF RAF1
27	Corticotropin-releasing hormone signaling pathway ¹	11.67	BRAF RAF1
28	EGF/EGFR Signaling Pathway ¹	11.65	BRAF PTPN11 RAF1
29	VEGF Pathway (Tocris) ⁶² Show member pathways VEGF Pathway ⁷³	11.6	BRAF RAF1
30	Bladder cancer ¹ ³⁸	11.54	BRAF RAF1
31	Development EGFR signaling via small GTPases ²³ Show member pathways Development EGFR signaling via PIP3 ²³ Development PDGF signaling via MAPK cascades ²³ PDGF Pathway ¹	11.51	PRKAR1A PTPN11 RAF1
32	Human Thyroid Stimulating Hormone (TSH) signaling pathway ¹	11.5	BRAF RAF1
33	Negative regulation of MAPK pathway ⁶⁷ Show member pathways RAF activation ⁶⁷	11.48	BRAF RAF1
34	G-protein signaling TC21 regulation pathway ²³ Show member pathways G-protein signaling M-RAS regulation pathway ²³ Negative feedback regulation of MAPK pathway ⁶⁷	11.44	BRAF RAF1
35	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.44	BRAF RAF1
36	mTOR signaling pathway (Pathway Interaction Database) ¹	11.44	BRAF RAF1
37	G-protein signaling_RhoA regulation pathway ²³	11.43	BRAF PRKAR1A RAF1
38	Long-term depression ³⁸	11.42	BRAF RAF1
39	Signaling events mediated by focal adhesion kinase ¹	11.37	BRAF RAF1
40	G-protein signaling_Rap1A regulation pathway ²³	11.33	BRAF RAF1
41	Semaphorin Signaling ⁶⁵	11.32	BRAF RAF1
42	Immune response_Role of integrins in NK cells cytotoxicity ²³	11.25	PTPN11 RAF1
43	Interleukin-11 Signaling Pathway ¹	11.25	PTPN11 RAF1
44	Vemurafenib Pathway, Pharmacodynamics ⁶²	11.23	BRAF RAF1
45	Melanocyte Development and Pigmentation ⁶⁵	11.2	MC1R PRKAR1A
46	Immune response_IL-6 signaling pathway ²³	11.09	PTPN11 RAF1
47	Trk receptor signaling mediated by the MAPK pathway ¹ Show member pathways Signalling to ERK5 ⁶⁷	11.04	BRAF RAF1
48	G-protein signaling_Cross-talk between Ras-family GTPases ²³	11.03	BRAF PRKAR1A RAF1
49	Telomere Extension by Telomerase ⁶⁵ Show member pathways XAV939 inhibits tankyrase, stabilizing AXIN ⁶⁷	11.02	PTPN11 RAF1
50	Development_Leptin signaling via JAK/STAT and MAPK cascades ²³ Show member pathways phospho-PLA2 pathway ⁶⁷	11.01	PTPN11 RAF1

Sources

GO Terms for Lentigines

Biological processes related to Lentigines according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.67	BRAF PRKAR1A RAF1
2	platelet activation	GO:0030168	9.48	PTPN11 RAF1
3	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.46	BRAF RAF1
4	somatic stem cell population maintenance	GO:0035019	9.43	BRAF RAF1
5	heart development	GO:0007507	9.43	PRKAR1A PTPN11 RAF1
6	activation of MAPKK activity	GO:0000186	9.4	BRAF RAF1
7	thymus development	GO:0048538	9.37	BRAF RAF1
8	thyroid gland development	GO:0030878	9.32	BRAF RAF1
9	neurotrophin TRK receptor signaling pathway	GO:0048011	9.16	PTPN11 RAF1
10	face development	GO:0060324	8.96	BRAF RAF1
11	intracellular signal transduction	GO:0035556	8.92	BRAF MC1R PRKAR1A RAF1

Molecular functions related to Lentigines according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.43	BRAF PRKAR1A RAF1
2	MAP kinase kinase kinase activity	GO:0004709	9.16	BRAF RAF1
3	small GTPase binding	GO:0031267	8.96	BRAF RAF1
4	mitogen-activated protein kinase kinase binding	GO:0031434	8.62	BRAF RAF1

Sources

Sources for Lentigines

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia