Aliases & Classifications for Lentigines

MalaCards integrated aliases for Lentigines:

Name: Lentigines 56 54
Lentigo 71

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
lentigines:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 56 150900
MedGen 41 C0023321
UMLS 71 C0023321

Summaries for Lentigines

MalaCards based summary : Lentigines, also known as lentigo, is related to leopard syndrome and melanocytic nevus syndrome, congenital. An important gene associated with Lentigines is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Aldosterone synthesis and secretion. The drugs Aminolevulinic acid and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lymph node, and related phenotypes are nystagmus and abnormality of the skin

Wikipedia : 74 A lentigo (/l?n'ta?go?/) (plural lentigines, /l?n't?d??ni?z/) is a small pigmented spot on the skin with... more...

More information from OMIM: 150900

Related Diseases for Lentigines

Diseases related to Lentigines via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 leopard syndrome 33.1 RAF1 PTPN11 BRAF
2 melanocytic nevus syndrome, congenital 32.4 PRKAR1A MC1R
3 noonan syndrome 1 31.6 RAF1 PTPN11 BRAF
4 nodular malignant melanoma 30.0 MC1R BRAF
5 hypertelorism 29.8 RAF1 PTPN11 BRAF
6 skin melanoma 29.7 MC1R BRAF
7 hypertrophic cardiomyopathy 29.7 RAF1 PTPN11 BRAF
8 pulmonic stenosis 29.1 RAF1 PTPN11 BRAF
9 rasopathy 29.1 RAF1 PTPN11 BRAF
10 melanoma, cutaneous malignant 1 29.0 RAF1 MC1R BRAF
11 acral lentiginous melanoma 12.8
12 leopard syndrome 1 12.1
13 gastrocutaneous syndrome 12.1
14 carney complex variant 12.0
15 lentiginosis, inherited patterned 11.6
16 phacomatosis pigmentokeratotica 11.5
17 phakomatosis pigmentokeratotica 11.5
18 dyschromatosis universalis hereditaria 1 11.5
19 leopard syndrome 2 11.5
20 leopard syndrome 3 11.5
21 uv-sensitive syndrome 11.3
22 nevoid hypermelanosis, linear and whorled 11.2
23 spastic paraplegia 23, autosomal recessive 11.1
24 legius syndrome 11.1
25 melanoma 10.9
26 dowling-degos disease 1 10.6
27 pseudo-turner syndrome 10.5
28 alstrom syndrome 10.4
29 keratosis 10.4
30 skin carcinoma 10.4
31 pustulosis of palm and sole 10.4
32 psoriasis 10.4
33 peutz-jeghers syndrome 10.3
34 neurofibromatosis, type iv, of riccardi 10.3
35 branchiootic syndrome 1 10.3
36 superficial spreading melanoma 10.3
37 spitz nevus 10.3
38 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
39 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
40 lentigo maligna melanoma 10.2
41 phacomatosis pigmentovascularis 10.2
42 keratosis, seborrheic 10.1
43 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1
44 basal cell carcinoma 10.1
45 dermatitis 10.1
46 pulmonary valve stenosis 10.1
47 inverted follicular keratosis 10.1
48 actinic keratosis 10.1
49 atrial standstill 1 10.1
50 mycosis fungoides 10.1

Graphical network of the top 20 diseases related to Lentigines:



Diseases related to Lentigines

Symptoms & Phenotypes for Lentigines

Human phenotypes related to Lentigines:

31
# Description HPO Frequency HPO Source Accession
1 nystagmus 31 HP:0000639
2 abnormality of the skin 31 HP:0000951

Symptoms via clinical synopsis from OMIM:

56
Eyes:
nystagmus

Skin:
lentigines

Clinical features from OMIM:

150900

GenomeRNAi Phenotypes related to Lentigines according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.68 BRAF
2 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.68 PTPN11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.68 PTPN11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.68 PTPN11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.68 BRAF PTPN11 RAF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.68 RAF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.68 RAF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.68 BRAF
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 BRAF
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.68 PTPN11
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.68 PTPN11
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.68 BRAF
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.68 BRAF
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.68 BRAF
15 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 BRAF
16 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.68 PTPN11
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.68 BRAF PTPN11
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.68 RAF1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 PTPN11
20 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.68 PTPN11

MGI Mouse Phenotypes related to Lentigines:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 BRAF MC1R PRKAR1A PTPN11 RAF1
2 cardiovascular system MP:0005385 9.91 BRAF MC1R PRKAR1A PTPN11 RAF1
3 cellular MP:0005384 9.89 BRAF MC1R PRKAR1A PTPN11 RAF1
4 craniofacial MP:0005382 9.88 BRAF MC1R PRKAR1A PTPN11 RAF1
5 hematopoietic system MP:0005397 9.83 BRAF MC1R PRKAR1A PTPN11 RAF1
6 immune system MP:0005387 9.8 BRAF MC1R PRKAR1A PTPN11 RAF1
7 integument MP:0010771 9.77 BRAF MC1R PRKAR1A PTPN11 RAF1
8 hearing/vestibular/ear MP:0005377 9.76 BRAF MC1R PTPN11 RAF1
9 liver/biliary system MP:0005370 9.62 BRAF PRKAR1A PTPN11 RAF1
10 muscle MP:0005369 9.56 BRAF PRKAR1A PTPN11 RAF1
11 neoplasm MP:0002006 9.55 BRAF MC1R PRKAR1A PTPN11 RAF1
12 pigmentation MP:0001186 9.26 BRAF MC1R PRKAR1A PTPN11
13 respiratory system MP:0005388 8.92 BRAF PRKAR1A PTPN11 RAF1

Drugs & Therapeutics for Lentigines

Drugs for Lentigines (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 4 106-60-5 137
2
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
3 Photosensitizing Agents Phase 4
4 retinol Phase 4
5 Retinol palmitate Phase 4
6 Arnica Phase 4
7 Methyl 5-aminolevulinate Phase 4
8
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
9 Adjuvants, Immunologic Phase 2, Phase 3
10 Immunologic Factors Phase 3
11 Interferon Inducers Phase 2, Phase 3
12 interferons Phase 2, Phase 3
13
Hydroquinone Approved, Investigational Phase 2 123-31-9 785
14
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 2 67-73-2 6215
15
Vitamin C Approved, Nutraceutical Phase 2 50-81-7 5785 54670067
16
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
17
Cediranib Investigational Phase 2 288383-20-0 9933475
18
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
19 Trace Elements Phase 2
20 Vitamins Phase 2
21 Micronutrients Phase 2
22 Nutrients Phase 2
23 Antioxidants Phase 2
24 Hormone Antagonists Phase 2
25 Protective Agents Phase 2
26 Anti-Inflammatory Agents Phase 2
27 glucocorticoids Phase 2
28 Radiation-Protective Agents Phase 2
29 Hormones Phase 2
30 Protein Kinase Inhibitors Phase 2
31
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
32 Anti-Infective Agents Phase 1
33 Antiviral Agents Phase 1
34 Ganciclovir triphosphate Phase 1
35
Neomycin Approved, Vet_approved 1404-04-2 8378
36
Clobetasol Approved, Experimental, Investigational 25122-46-7, 25122-41-2 32798 5311051
37
Tazarotene Approved, Investigational 118292-40-3 5381
38
Nicotinamide Approved, Investigational 98-92-0 936
39
Ethanol Approved 64-17-5 702
40
Desonide Approved, Investigational 638-94-8 5311066
41
Glycolic acid Approved, Investigational 79-14-1 757
42
Lidocaine Approved, Vet_approved 137-58-6 3676
43
Prilocaine Approved 721-50-6 4906
44
Tetracaine Approved, Vet_approved 94-24-6 5411
45
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
46
Niacin Approved, Investigational, Nutraceutical 59-67-6 938
47 Antibiotics, Antitubercular
48 Anti-Bacterial Agents
49 Vitamin B3
50 Vitamin B Complex

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 The Comparison of Picosecond 532 and 1,064 Nanometers Laser and Q-switched Nd:YAG 532 and 1,064 Nanometers Laser in the Treatment of Benign Pigmented Lesions: A Randomized Controlled Trial Unknown status NCT02800525 Phase 4
2 Effect of Topical Imiquimod on Lentigo Maligna Completed NCT01161888 Phase 4 Imiquimod
3 Photodynamic Therapy for Melanoma Precursor Lesion Lentigo Maligna Using 5-aminolevulinic Acid Nanoemulsion (BF-200 ALA) as a Light Sensitizing Cream Completed NCT02685592 Phase 4 5-aminolevulinic acid nanoemulsion
4 Randomized, Double-Blind, Contralateral, Controlled Study to Assess the Efficacy of DerMend Moisturizing Bruise Formula in Improving the Appearance of Chronically Aged Mature Skin of the Forearms and Hands Completed NCT01910831 Phase 4 DerMend Moisturizing Bruise Formula;Non-active placebo control
5 Treatment of Photodamaged Skin of the décolleté With Fractional Laser, Radio-frequency Microneedling, and Photodynamic Therapy Recruiting NCT03573076 Phase 4
6 A Randomized, Double-Blind, Placebo-Controlled Trial of Methyl Aminolevulinate + Aktilite in Patients With Facial Photodamage Completed NCT00629317 Phase 3 Methyl Aminolevulinate
7 Clinical Study for the Evaluation of the Depigmenting Activity of a Cosmetic Product on Spotted Hand Skin Completed NCT02204436 Phase 3
8 A Randomised Controlled Multicentre Trial of Imiquimod Versus Radiotherapy for Lentigo Maligna (LM) When Staged Surgical Excision With 5mm Margins is Not Possible, is Refused, or Fails Recruiting NCT02394132 Phase 3 Imiquimod
9 An Open Monocentric Pilot Study to Investigate the Potential of Imiquimod 5% Cream to Detect Residual and to Prevent Recurrence of Lentigo Maligna After Surgical Excision Active, not recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
10 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Active, not recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
11 Phase 2 Study of the Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging Unknown status NCT02126644 Phase 2 70% glycolic acid
12 Solar Lentigines Treatment With the Triple Combination Cream (Hydroquinone 4%, Tretinoin 0.05%, and Fluocinolone Acetonide 0.01%). Randomized, Double Blind, Controlled Trial. Completed NCT00975312 Phase 2 Triple combination cream;Tretinoin 0.05%
13 Efficacy and Side Effects of Q-Switched Ruby Laser Treatment of Solar Lentigines in Two Different Fitzpatrick Skin Types II and IV Completed NCT00386204 Phase 2
14 A Phase II Study of AZD2171 in Previously Untreated Patients With Metastatic or Recurrent Malignant Melanoma Completed NCT00243061 Phase 2 cediranib maleate
15 Prospective Study of Ingenol Mebutate for Non-invasive Lentigo Melanoma of the Face - Study PICAMEL Recruiting NCT02723721 Phase 2 Picato gel
16 A Phase II Trial of SCH 727965 (NSC 747135) in Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
17 Phase II Study of RO4929097 (NSC-749225) in Advanced Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
18 A Phase I Study of Intralesional Administration of an Adenovirus Vector Expressing the HSV-1 Thymidine Kinase Gene (AdV.RSV-TK) in Combination With Escalating Doses of Ganciclovir in Patients With Cutaneous Metastatic Malignant Melanoma Completed NCT00005057 Phase 1 ganciclovir
19 Clinical, Histological and Biochemical Characterization of Hyperpigmented Lesion. Unknown status NCT01136629
20 Evaluate the Lightening Effect of the Whitening Cosmetic Product BEX-2011 on Solar Lentigines by Harmonic Generation Microscopy Unknown status NCT01249469
21 Open-label, Prospective, Multicenter Study to Evaluate the Cutera Excel V™ Laser and a Micro-Lens Array Attachment Unknown status NCT03424148
22 Study for the RevLite Laser System for Facial Solar Lentigines Completed NCT02110108
23 A Single-Center 2-Arm Study of the Enlighten and Excel V Laser for Lentigines on the Hands Completed NCT02763072
24 Clinical Evaluation of the Performance of a Difluoroethane-based Cyto-selective Cryotherapy to Treat Dark Spots on the Hand in 30 Volunteers. Completed NCT03157427
25 Comparative Study Investigating the Therapy of of Solar Lentigines With the Q-switched SINON Rubin 694nm Laser Versus Pigmanorm® Cream Completed NCT02153697 Pigmanorm Cream
26 A Prospective Multi-Center Study of a Novel Dual-Wavelength, Dual-Pulse Duration Laser for the Treatment of Melasma and Lentigines in Asian Skin Completed NCT02385994
27 Safety and Efficacy of a Triple Combination Cream as Adjuvant Treatment of Solar Lentigines With Cryotherapy. Completed NCT01778179 Tri-luma
28 Safety and Efficacy of Cutera Picosecond Q-Switched Nd:YAG Laser in the Treatment of Solar Lentigines Completed NCT01885871
29 Prospective Clinical Trial to Assess the Performance of a Cyto-selective Cryotherapye "CRYOBEAUTY MAINS ET DECOLLETE" Compared With Liquid Nitrogen Cryotherapy in the Treatment of Solar Lentigines in 30 Patients Completed NCT03225729
30 Effect of Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation Following Q-switched Nd:YAG 532 nm Laser for Treatment of Facial Lentigines - A Pilot Study Completed NCT02492373 topical 0.05% Clobetasol propionate ointment
31 Efficacy and Tolerance of D-pigment Versus Moisturizer in Hands' Lentigo Lesions With or Without Laser Therapy Completed NCT03457246
32 Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna Completed NCT00707174 Imiquimod Cream;Tazarotene Cream 0.1%
33 In Vivo Reflectance Confocal Microscopy for Pigmented Lesion Diagnosis: A Multi-center Study Completed NCT00785369
34 Nanocytology Evaluation of Epidermal Cells to Assess Risk of Squamous Cell Carcinoma and Field Cancerization in High Risk Patients Completed NCT01905891
35 Clinical and Histological Analysis of Photoaging Treatment With Imiquimod Cream 5% Completed NCT01935310 Imiquimod
36 A Single-Center Open-Label Study of 1064 nm Nd:YAG for Nonablative Skin Rejuvenation Recruiting NCT03421691
37 Reflectance Confocal Microscopy to Diagnose Malignant Melanoma and Lentigo Maligna Recruiting NCT03508297
38 Melanoma Family Case-Control Study Protocol Recruiting NCT00445783
39 Effectiveness, Safety, and Cost Efficacy of Water (H2O) as a Substitute for Sodium Bicarbonate (NaHCO3) Plus Solution in Neutralization of Chemical Peeling Using 35% Glycolic Acid Solution Recruiting NCT04154436
40 Definition of the Genotype and Clinical Phenotype of Primary Pigmented Nodular Adrenocortical Disease (PPNAD), Carney Complex, Peutz-Jeghers Syndrome and Related Conditions Recruiting NCT00001452
41 Studies of Familial Melanoma Recruiting NCT00450593
42 The Effect of Topical Anesthetic Using Lidocaine 2.5%/Prilocaine 2.5% Versus Lidocaine 7%/Tetracaine 7% Cream on Patients' Pain and Operative Experience During Treatment With QSwitched 532nm Laser Active, not recruiting NCT02427724 lidocaine 2.5%/prilocaine 2.5% topical anesthetic;lidocaine 7%/tetracaine 7% topical anesthetic;placebo vehicle
43 Advanced Harmonic Generation Microscopy for Treatment Assessment of Cutaneous Pigmentary Disorder Not yet recruiting NCT03578315
44 A Safety and Effectiveness Study of Intratumoral Diffusing Alpha Radiation Emitters for the Treatment of Malignant Cutaneous Tumors Not yet recruiting NCT04068155
45 The Role of Dermoscopy in Diagnosis of Pigmentary Skin Lesions Not yet recruiting NCT03542539
46 Open Label, Prospective, Single-Center Pilot Study to Evaluate the Effect of Multiple Passes on Port Wine Stain Treatments With the Cutera Excel V™ Laser. Suspended NCT04103164
47 Mohs Micrographic Surgery for Primary Cutaneous Malignant Melanoma In Situ Using Immunofluorescence Withdrawn NCT02306512

Search NIH Clinical Center for Lentigines

Genetic Tests for Lentigines

Anatomical Context for Lentigines

MalaCards organs/tissues related to Lentigines:

40
Skin, Heart, Lymph Node, Thyroid, Breast, Pituitary, Bone

Publications for Lentigines

Articles related to Lentigines:

(show top 50) (show all 2344)
# Title Authors PMID Year
1
A pedigree of generalized lentigo. 61 56
15422118 1950
2
A novel PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease and the Carney complex. 54 61
19833579 2010
3
PTPN11 gene mutation and severe neonatal hypertrophic cardiomyopathy: what is the link? 54 61
19582499 2009
4
Heterogeneity of skin manifestations in patients with Carney complex. 54 61
18804312 2008
5
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders. 54 61
18470943 2008
6
Polymorphism patterns in the promoter region of the MC1R gene are associated with development of freckles and solar lentigines. 54 61
18079748 2008
7
Effect of Val92Met and Arg163Gln variants of the MC1R gene on freckles and solar lentigines in Japanese. 54 61
17371441 2007
8
PTPN11 gene mutations: linking the Gln510Glu mutation to the "LEOPARD syndrome phenotype". 54 61
16733669 2006
9
Association between endothelin receptor B nonsynonymous variants and melanoma risk. 54 61
16145050 2005
10
A novel PTPN11 gene mutation bridges Noonan syndrome, multiple lentigines/LEOPARD syndrome and Noonan-like/multiple giant cell lesion syndrome. 54 61
15470362 2004
11
Clinical and molecular genetics of primary pigmented nodular adrenocortical disease. 54 61
15761532 2004
12
c-kit Mutation in generalized lentigines associated with gastrointestinal stromal tumor. 54 61
15118370 2004
13
Clinical and molecular genetics of Carney complex. 54 61
12666684 2003
14
PTPN11 mutations in LEOPARD syndrome. 54 61
12161596 2002
15
The melanocortin-1-receptor gene is the major freckle gene. 54 61
11487574 2001
16
Genetics of Peutz-Jeghers syndrome, Carney complex and other familial lentiginoses. 54 61
11595829 2000
17
Cardiac manifestations and gene mutations of patients with RASopathies in Taiwan. 61
31837205 2020
18
Efficacy of Imiquimod 3.75% cream for the treatment of solar lentigo. 61
32031733 2020
19
Incompletely excised lentigo maligna melanoma is associated with unpredictable residual disease: clinical features and the emerging role of reflectance confocal microscopy. 61
32030827 2020
20
Progressive Disease in Sentinel-negative Melanoma Patients: Biological Differences and Importance of Sentinel Lymph Node Biopsy. 61
32014933 2020
21
Poor agreement between the automated risk assessment of a smartphone application for skin cancer detection and the rating by dermatologists. 61
31423673 2020
22
Factors associated with sentinel lymph node status and prognostic role of completion lymph node dissection for thick melanoma. 61
31594672 2020
23
Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma. 61
31972665 2020
24
Melanoma recognition by a deep learning convolutional neural network-Performance in different melanoma subtypes and localisations. 61
31972395 2020
25
Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines. 61
31892612 2020
26
Increased melanocytic nevi and lentigines in two patients with harlequin ichthyosis. 61
31765010 2020
27
[Facial skin cancers: Comparison of opinions in French multidisciplinary team meetings]. 61
32005508 2020
28
Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. 61
31325402 2020
29
Commentary on: Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. 61
31930647 2020
30
Upstaging of melanoma in situ and lentigo maligna treated with Mohs micrographic surgery rarely results in additional surgical management. 61
32002653 2020
31
Chemical peeling for acne and melasma: current status and innovations. 61
31804050 2019
32
A Prospective Randomized Controlled Study of Oral Tranexamic Acid for the Prevention of Postinflammatory Hyperpigmentation After Q-Switched 532-nm Nd:YAG Laser for Solar Lentigines. 61
31302943 2019
33
The Role of Stem Cell Factor in Hyperpigmented Skin Lesions. 61
31870114 2019
34
Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions. 61
31562133 2019
35
Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study. 61
31812621 2019
36
A meta-analysis comparing confocal microscopy and dermoscopy in diagnostic accuracy of lentigo maligna. 61
31811677 2019
37
Repigmentation of gray hairs with lentigo maligna and response to topical imiquimod. 61
31763424 2019
38
The dermoscopic features of facial aging among Egyptians: A comparative study between males and females. 61
30884122 2019
39
The anatomic distribution of cutaneous melanoma: A detailed study of 5141 lesions. 61
31880825 2019
40
Anti-melanogenic activity of salacinol by inhibition of tyrosinase oligosaccharide processing. 61
31883005 2019
41
Mohs surgery for the treatment of lentigo maligna and lentigo maligna melanoma - a systematic review. 61
31696746 2019
42
Novel KIT mutation presenting as marked lentiginosis. 61
31497890 2019
43
A cross-sectional analysis of skin cancer risk in patients receiving narrow-band ultraviolet B phototherapy: an evaluation of 100 patients. 61
31729594 2019
44
A Prospective Study in the Treatment of Lentigines in Asian Skin Using 532 nm Picosecond Nd:YAG Laser. 61
31115070 2019
45
The Itch that… freckles? Development of lentigines in areas of resolved chronic atopic dermatitis. 61
31497891 2019
46
Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century. 61
31006857 2019
47
Epidermal keratin 5 expression and distribution is under dermal influence. 61
31692218 2019
48
Neck Melanoma: Clinical, Dermoscopic and Confocal Features. 61
31707398 2019
49
Key dermoscopic signs in the diagnosis and progression of extrafacial lentigo maligna: Evaluation of a series of 41 cases. 61
30997681 2019
50
Gamma Knife Radiosurgery and Immunotherapy as Primary Treatment for a Malignant Tumor of the Cranial Base Beginning as Lentigo Maligna: A Case Report. 61
31129314 2019

Variations for Lentigines

Expression for Lentigines

Search GEO for disease gene expression data for Lentigines.

Pathways for Lentigines

Pathways related to Lentigines according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 RAF1 PRKAR1A BRAF
2
Show member pathways
12.64 RAF1 MC1R BRAF
3
Show member pathways
12.62 RAF1 PRKAR1A BRAF
4
Show member pathways
12.61 RAF1 PRKAR1A BRAF
5
Show member pathways
12.61 RAF1 PTPN11 BRAF
6
Show member pathways
12.55 RAF1 PRKAR1A BRAF
7
Show member pathways
12.52 RAF1 PTPN11 BRAF
8
Show member pathways
12.47 RAF1 PTPN11 BRAF
9
Show member pathways
12.45 RAF1 PTPN11 BRAF
10
Show member pathways
12.4 RAF1 PRKAR1A BRAF
11
Show member pathways
12.4 RAF1 PRKAR1A BRAF
12
Show member pathways
12.34 RAF1 PTPN11 BRAF
13
Show member pathways
12.27 RAF1 PTPN11 PRKAR1A
14
Show member pathways
12.2 RAF1 PTPN11 BRAF
15
Show member pathways
12.03 RAF1 PTPN11 BRAF
16
Show member pathways
12.03 RAF1 PTPN11 PRKAR1A BRAF
17
Show member pathways
12 RAF1 PTPN11 BRAF
18
Show member pathways
11.95 RAF1 PRKAR1A BRAF
19 11.85 RAF1 PTPN11 BRAF
20 11.74 RAF1 BRAF
21 11.74 RAF1 BRAF
22 11.72 RAF1 BRAF
23 11.71 RAF1 PTPN11 BRAF
24
Show member pathways
11.69 RAF1 PTPN11
25 11.69 RAF1 BRAF
26 11.67 RAF1 BRAF
27
Show member pathways
11.62 RAF1 PTPN11
28
Show member pathways
11.61 RAF1 BRAF
29
Show member pathways
11.61 RAF1 PTPN11 PRKAR1A
30
Show member pathways
11.59 RAF1 PTPN11 BRAF
31 11.55 RAF1 BRAF
32 11.51 RAF1 BRAF
33
Show member pathways
11.48 RAF1 BRAF
34
Show member pathways
11.45 RAF1 BRAF
35 11.44 RAF1 BRAF
36 11.43 RAF1 BRAF
37 11.43 RAF1 PRKAR1A BRAF
38 11.37 RAF1 BRAF
39 11.34 RAF1 BRAF
40 11.33 RAF1 BRAF
41 11.27 RAF1 PTPN11
42 11.26 RAF1 PTPN11
43
Show member pathways
11.26 RAF1 BRAF
44 11.24 RAF1 BRAF
45 11.21 PRKAR1A MC1R
46 11.16 RAF1 BRAF
47 11.08 RAF1 PTPN11
48
Show member pathways
11.03 RAF1 BRAF
49
Show member pathways
11.02 RAF1 PTPN11
50
Show member pathways
10.99 RAF1 PTPN11

GO Terms for Lentigines

Biological processes related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.46 RAF1 BRAF
2 somatic stem cell population maintenance GO:0035019 9.43 RAF1 BRAF
3 heart development GO:0007507 9.43 RAF1 PTPN11 PRKAR1A
4 thymus development GO:0048538 9.4 RAF1 BRAF
5 activation of MAPKK activity GO:0000186 9.37 RAF1 BRAF
6 thyroid gland development GO:0030878 9.32 RAF1 BRAF
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 RAF1 PTPN11
8 face development GO:0060324 8.96 RAF1 BRAF
9 intracellular signal transduction GO:0035556 8.92 RAF1 PRKAR1A MC1R BRAF

Molecular functions related to Lentigines according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 small GTPase binding GO:0031267 9.26 RAF1 BRAF
2 MAP kinase kinase kinase activity GO:0004709 9.16 RAF1 BRAF
3 Ras GTPase binding GO:0017016 8.96 RAF1 BRAF
4 mitogen-activated protein kinase kinase binding GO:0031434 8.62 RAF1 BRAF

Sources for Lentigines

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....