LMM
MCID: LNT002
MIFTS: 33

Lentigo Maligna Melanoma (LMM)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lentigo Maligna Melanoma

MalaCards integrated aliases for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 20 70
Hutchison Melanotic Freckle 20
Lmm 20

Classifications:



External Ids:

UMLS 70 C2739810

Summaries for Lentigo Maligna Melanoma

GARD : 20 Lentigo maligna melanoma (LMM) is a type of skin cancer that usually develops in older, fair-skinned adults. The average age of diagnosis is 65. LMM is thought to be caused by a history of sun exposure to the affected area. Treatment includes surgery to remove as much of the LMM as possible.

MalaCards based summary : Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to nodular malignant melanoma and keratosis, seborrheic. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor), and among its related pathways/superpathways are Glioma and Interleukin-4 and 13 signaling. The drugs Imiquimod and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and testis, and related phenotypes are integument and neoplasm

Related Diseases for Lentigo Maligna Melanoma

Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 nodular malignant melanoma 30.8 MLANA MITF MC1R
2 keratosis, seborrheic 30.7 MLANA MC1R
3 basal cell carcinoma 30.5 MMP9 MMP2 MC1R
4 malignant spindle cell melanoma 30.5 MLANA MITF
5 amelanotic melanoma 30.4 S100B MLANA
6 vitiligo-associated multiple autoimmune disease susceptibility 1 30.2 MLANA MITF MC1R
7 actinic keratosis 30.1 MMP9 MMP2 MITF MC1R
8 skin carcinoma 30.0 MMP9 MMP2 MLANA MITF MC1R
9 ocular melanoma 29.9 S100B MC1R
10 melanoma 29.7 TIMP1 S100B MMP9 MMP2 MLANA MITF
11 gastrointestinal stromal tumor 29.5 S100B MMP9 MMP2
12 microphthalmia 29.5 S100B MLANA MITF MC1R
13 skin melanoma 29.0 S100B MMP9 MMP2 MLANA MITF MC1R
14 lentigines 11.3
15 superficial spreading melanoma 10.6
16 keratosis 10.5
17 dowling-degos disease 1 10.3
18 malignant conjunctival melanoma 10.3
19 dermatitis 10.3
20 inverted follicular keratosis 10.3
21 ochronosis 10.2 MITF MC1R
22 pigmented basal cell carcinoma 10.2 MLANA MITF
23 gallbladder melanoma 10.2 MLANA MITF
24 epithelioid cell melanoma 10.2 MLANA MITF
25 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
26 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
27 xeroderma pigmentosum, variant type 10.2
28 dermatomyositis 10.2
29 squamous cell carcinoma 10.2
30 neurodermatitis 10.2
31 cellulitis 10.2
32 skin disease 10.2
33 merkel cell carcinoma 10.2
34 superficial basal cell carcinoma 10.2
35 acral lentiginous melanoma 10.2
36 lichen planus 10.2
37 actinic lichen planus 10.2
38 bowen's disease 10.2
39 tièche-jadassohn nevus 10.2
40 uterus perivascular epithelioid cell tumor 10.2 MLANA MITF
41 perivascular epithelioid cell tumor 10.2 MLANA MITF
42 malignant choroid melanoma 10.2 MLANA MITF
43 perivascular tumor 10.1 MLANA MITF
44 piebald trait 10.1 MITF MC1R
45 vascular cancer 10.1 MLANA MITF
46 angiomyolipoma 10.1 MLANA MITF
47 hypertrophic scars 10.1 TIMP1 MMP2
48 hemorrhoid 10.0 MMP9 MLANA
49 extracranial arteriovenous malformation 10.0 MMP9 MMP2
50 focal myositis 10.0 MMP9 MMP2

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to Lentigo Maligna Melanoma

Symptoms & Phenotypes for Lentigo Maligna Melanoma

MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 MC1R MITF MLANA MMP9 S100B
2 neoplasm MP:0002006 8.92 MC1R MMP2 MMP9 TIMP1

Drugs & Therapeutics for Lentigo Maligna Melanoma

Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
2 Immunologic Factors Phase 3
3 Adjuvants, Immunologic Phase 3
4 interferons Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Active, not recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

Anatomical Context for Lentigo Maligna Melanoma

MalaCards organs/tissues related to Lentigo Maligna Melanoma:

40
Lymph Node, Skin, Testis

Publications for Lentigo Maligna Melanoma

Articles related to Lentigo Maligna Melanoma:

(show top 50) (show all 502)
# Title Authors PMID Year
1
Handheld reflectance confocal microscopy: Personalized and accurate presurgical delineation of lentigo maligna (melanoma). 61
33231342 2021
2
Mohs surgery for the treatment of lentigo maligna and lentigo maligna melanoma - a systematic review. 61
31696746 2021
3
Folliculotropism in head and neck lentigo maligna and lentigo maligna melanoma. 61
33166059 2021
4
May melanophages hinder the subclinical spread of lentigo maligna and lentigo maligna melanoma? Results from a pilot study. 61
33462879 2021
5
Pitfalls in the diagnosis of lentigo maligna and lentigo maligna melanoma, facts and an opinion. 61
33051287 2021
6
Lentiginous melanoma (lentigo maligna and lentigo maligna melanoma) in Australia: clinicopathological characteristics, management and recurrence rates after 10-year follow-up at a tertiary centre. 61
33502077 2021
7
Association of Mohs Micrographic Surgery vs Wide Local Excision With Overall Survival Outcomes for Patients With Melanoma of the Trunk and Extremities. 61
33084853 2021
8
Immunohistochemical study of CD117 in various cutaneous melanocytic lesions. 61
33363589 2021
9
Subtyping Cutaneous Melanoma Matters. 61
33409460 2020
10
Basal cell carcinoma colonized by lentigo maligna melanoma, with perineural invasion by both neoplasms. 61
32989833 2020
11
Lentigo maligna melanoma in situ with neurotropism. 61
32557727 2020
12
Eyelid reconstruction with modified Tenzel flap after lentigo maligna melanoma resection. 61
32989892 2020
13
In vivo and ex vivo confocal microscopy for the evaluation of surgical margins of melanoma. 61
32706484 2020
14
Positive Margins in Cutaneous Melanoma of the Head and Neck: Implications for Timing of Reconstruction. 61
33138702 2020
15
Ten-year Follow-up Study of Grenz Ray Treatment for Lentigo Maligna and Early Lentigo Maligna Melanoma. 61
32926174 2020
16
Incompletely excised lentigo maligna melanoma is associated with unpredictable residual disease: clinical features and the emerging role of reflectance confocal microscopy. 61
32030827 2020
17
[Rotation advancement flap with subcutaneous pedicle in the jugal region following excision of lentigo maligna melanoma]. 61
32680709 2020
18
[Atypical presentation of lentigo maligna melanoma]. 61
33000739 2020
19
Superficial dermal melanocytosis of the elderly: An exceptional occurrence? 61
32388873 2020
20
Clinical and Demographic Profile of Cutaneous Melanoma: Pakistani Perspective. 61
33330006 2020
21
[Ancillary values of fluorescence in situ hybridization with different gene combination in diagnosis of malignant melanoma]. 61
32746551 2020
22
Long-term relative survival from melanoma in Germany 1997-2013. 61
30020195 2020
23
Differential Expression of Cancer Testis Antigens on Lentigo Maligna and Lentigo Maligna Melanoma. 61
32701706 2020
24
Utility of confocal microscopy in the management of lentigo maligna and lentigo maligna melanoma. 61
32871163 2020
25
Topical Imiquimod for Management of Recurrent Lentigo Maligna Melanoma in Situ. 61
32650849 2020
26
Dermoscopic predictors to discriminate between in situ and early invasive lentigo maligna melanoma: A retrospective observational study. 61
32199898 2020
27
Radiotherapy for lentigo maligna and lentigo maligna melanoma - a systematic review. 61
32664998 2020
28
Amelanotic melanoma in a patient with oculocutaneous albinism. 61
32621707 2020
29
Estimated risk of progression of lentigo maligna to lentigo maligna melanoma. 61
31095041 2020
30
Ablative fractional laser-assisted photodynamic therapy for lentigo maligna: a prospective pilot study. 61
31465596 2020
31
Factors associated with sentinel lymph node status and prognostic role of completion lymph node dissection for thick melanoma. 61
31594672 2020
32
Progressive Disease in Sentinel-negative Melanoma Patients: Biological Differences and Importance of Sentinel Lymph Node Biopsy. 61
32014933 2020
33
Neck Melanoma: Clinical, Dermoscopic and Confocal Features. 61
31707398 2020
34
Use of a Topical Film-Forming Medical Device Containing Repairsomes® in a Patient with Xeroderma Pigmentosum to Avoid Progression to Skin Cancerization. 61
32982361 2020
35
Mutations in the BRAF, NRAS, and C-KIT Genes of Patients Diagnosed with Melanoma in Colombia Population. 61
32775409 2020
36
Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. 61
31325402 2020
37
Evidence-Based Clinical Practice Guidelines for the Management of Patients with Lentigo Maligna. 61
31639788 2020
38
Lentigo Maligna: Clinical Presentation and Appropriate Management. 61
33223843 2020
39
Commentary on: Reflectance confocal microscopy and dermoscopy aid in evaluating repigmentation within or adjacent to lentigo maligna melanoma surgical scars. 61
31930647 2020
40
Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study. 61
31812621 2019
41
[Diagnostics and treatment of lentigo maligna melanoma in Denmark]. 61
31791471 2019
42
Clinical usefulness of dermoscopy in the management of lentigo maligna melanoma treated with topical imiquimod: A case report. 61
31365164 2019
43
Effectiveness of 5% Topical Imiquimod for Lentigo Maligna Treatment. 61
31233181 2019
44
Nine per cent of biopsy-proven lentigo maligna lesions are reclassified as lentigo maligna melanoma after surgery. 61
30716164 2019
45
Considerations for Timing of Defect Reconstruction in Cutaneous Melanoma of the Head and Neck. 61
31315133 2019
46
Histologic Features Associated With an Invasive Component in Lentigo Maligna Lesions. 61
31066867 2019
47
The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management. 61
30302753 2019
48
Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia. 61
30548854 2019
49
Reflectance confocal microscopy in the diagnosis of pigmented macules of the face: differential diagnosis and margin definition. 61
30938378 2019
50
Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. 61
30932370 2019

Variations for Lentigo Maligna Melanoma

Expression for Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for Lentigo Maligna Melanoma

Pathways related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 MMP9 MMP2 MITF
2 11.6 TIMP1 MMP9 MMP2
3
Show member pathways
11.49 TIMP1 MMP9 MMP2
4 11.4 MMP9 MMP2
5 11.38 MMP9 MMP2
6 11.38 TIMP1 MMP9 MMP2
7
Show member pathways
11.36 MMP9 MMP2
8 11.23 MMP9 MMP2 MITF
9 11.22 MMP9 MMP2
10
Show member pathways
11.18 MMP9 MMP2
11 11.12 MITF MC1R
12 11.03 MMP9 MMP2
13 10.98 MMP9 MMP2
14 10.93 TIMP1 MMP9 MMP2
15 10.87 MMP9 MMP2
16 10.83 TIMP1 MMP9
17 10.77 MMP9 MMP2
18 10.58 TIMP1 MMP9 MMP2

GO Terms for Lentigo Maligna Melanoma

Cellular components related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.8 TIMP1 MMP9 MMP2

Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.61 TIMP1 MMP9 MMP2
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.48 MMP9 MMP2
3 collagen catabolic process GO:0030574 9.46 MMP9 MMP2
4 cellular response to reactive oxygen species GO:0034614 9.4 MMP9 MMP2
5 embryo implantation GO:0007566 9.37 MMP9 MMP2
6 pigmentation GO:0043473 9.32 MITF MC1R
7 endodermal cell differentiation GO:0035987 9.26 MMP9 MMP2
8 response to amyloid-beta GO:1904645 9.16 MMP9 MMP2
9 extracellular matrix disassembly GO:0022617 9.13 TIMP1 MMP9 MMP2
10 cellular response to UV-A GO:0071492 8.8 TIMP1 MMP9 MMP2

Molecular functions related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.92 TIMP1 S100B MMP9 MMP2

Sources for Lentigo Maligna Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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