MCID: LNT002
MIFTS: 35

Lentigo Maligna Melanoma

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lentigo Maligna Melanoma

MalaCards integrated aliases for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 53 73
Hutchison Melanotic Freckle 53
Lmm 53

Classifications:



External Ids:

UMLS 73 C2739810

Summaries for Lentigo Maligna Melanoma

NIH Rare Diseases : 53 Lentigo maligna melanoma (LMM) is a type of skin cancer that usually develops in older, fair-skinned adults.  The average age of diagnosis is 65.  LMM is thought to be caused by a history of sun exposure to the affected area.  Treatment includes surgery to remove as much of the LMM as possible.

MalaCards based summary : Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and gallbladder melanoma. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Imiquimod and interferons have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are integument and pigmentation

Related Diseases for Lentigo Maligna Melanoma

Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 melanoma 31.2 MC1R MITF MLANA
2 gallbladder melanoma 10.3 MITF MLANA
3 basal cell carcinoma 1 10.3
4 basal cell carcinoma 10.3
5 superficial spreading melanoma 10.3
6 pigmented basal cell carcinoma 10.3 MITF MLANA
7 epithelioid cell melanoma 10.3 MITF MLANA
8 breast angiosarcoma 10.3 MITF MLANA
9 actinic keratosis 10.3 MC1R MMP2
10 nodular malignant melanoma 10.2
11 melanoma, cutaneous malignant 1 10.2 MC1R MITF
12 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2 MITF MLANA
13 albinism 10.1 MC1R MITF
14 neurofibroma 10.1 MITF S100B
15 lentigines 10.1
16 keratosis, seborrheic 10.1
17 xeroderma pigmentosum, variant type 10.1
18 aging 10.1
19 gastrointestinal stromal tumor 10.1
20 burns 10.1
21 skin disease 10.1
22 dermatomyositis 10.1
23 keratosis 10.1
24 squamous cell carcinoma 10.1
25 merkel cell carcinoma 10.1
26 acral lentiginous melanoma 10.1
27 tièche-jadassohn nevus 10.1
28 clear cell sarcoma 10.1 MITF S100B
29 meningeal melanocytoma 10.1 MLANA S100B
30 fibrous histiocytoma 10.1 MITF S100B
31 extracranial arteriovenous malformation 9.9 MMP2 MMP9
32 focal myositis 9.9 MMP2 MMP9
33 spastic entropion 9.9 MMP2 MMP9
34 villous adenocarcinoma 9.9 MMP2 MMP9
35 psammomatous meningioma 9.9 MMP2 MMP9
36 acute transverse myelitis 9.9 MMP2 MMP9
37 senile ectropion 9.9 MMP2 MMP9
38 internal hemorrhoid 9.9 MMP2 MMP9
39 ischemic colitis 9.9 MMP2 MMP9
40 parotitis 9.9 MMP2 MMP9
41 light chain deposition disease 9.9 MMP2 MMP9
42 klatskin's tumor 9.9 MMP2 MMP9
43 microcystic meningioma 9.9 MMP2 MMP9
44 adenomyosis 9.9 MMP2 MMP9
45 integumentary system cancer 9.8 MC1R MITF MLANA
46 corneal ulcer 9.8 MMP2 MMP9
47 transverse myelitis 9.8 MMP2 MMP9
48 sorsby fundus dystrophy 9.8 MMP2 MMP9
49 lung giant cell carcinoma 9.8 MMP2 MMP9
50 hypertensive heart disease 9.8 MMP2 MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to Lentigo Maligna Melanoma

Symptoms & Phenotypes for Lentigo Maligna Melanoma

MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 MC1R MITF MLANA MMP9 S100B
2 pigmentation MP:0001186 8.8 MC1R MITF MLANA

Drugs & Therapeutics for Lentigo Maligna Melanoma

Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 3,Phase 2 99011-02-6 57469
2 interferons Phase 3,Phase 2
3 Adjuvants, Immunologic Phase 3,Phase 2
4 Interferon Inducers Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
2 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Active, not recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
3 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
4 French Clinical Datbase of Melanoma Patients (RIC-Mel) Recruiting NCT03315468

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

Anatomical Context for Lentigo Maligna Melanoma

MalaCards organs/tissues related to Lentigo Maligna Melanoma:

41
Skin

Publications for Lentigo Maligna Melanoma

Articles related to Lentigo Maligna Melanoma:

(show top 50) (show all 140)
# Title Authors Year
1
Impact of Dermoscopy and Reflectance Confocal Microscopy on the Histopathologic Diagnosis of Lentigo Maligna/Lentigo Maligna Melanoma. ( 29933314 )
2018
2
Staged margin-controlled excision (SMEX) for lentigo maligna melanoma in situ. ( 29936706 )
2018
3
Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma. ( 29430695 )
2018
4
Repair of a Complex Marginal Auricular Defect After Lentigo Maligna Melanoma Excision. ( 29933298 )
2018
5
Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma. ( 29049429 )
2017
6
Synchronous conjunctival melanoma and lentigo maligna melanoma. ( 28954115 )
2017
7
TIMPs expression in lentigo malignaA^lentigo maligna melanoma versus aged skin - a review of the literature and personal experience. ( 29250646 )
2017
8
Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery. ( 28296789 )
2017
9
Lentigo maligna melanoma with a history of cosmetic treatment: Prevalence, surgical outcomes and considerations. ( 28555933 )
2017
10
Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion. ( 28785332 )
2017
11
Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour. ( 28685596 )
2017
12
Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma. ( 26771682 )
2016
13
A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures. ( 27987308 )
2016
14
Extrafacial lentigo maligna melanoma is reported often in Australia, more so at lower latitudes. ( 26820786 )
2016
15
Epidemiology of Lentigo Maligna andA Lentigo Maligna Melanoma in theA Netherlands, 1989-2013. ( 27349862 )
2016
16
Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma. ( 28012166 )
2016
17
Lifetime UV exposure and Lentigo Maligna Melanoma. ( 27925150 )
2016
18
Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice. ( 27386048 )
2016
19
Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. ( 26050216 )
2015
20
Curative Electrochemotherapy in Lentigo Maligna Melanoma. ( 26861530 )
2015
21
Lentigo Maligna Melanoma With Local and Distant Blue Nevus-like Metastases. ( 25943243 )
2015
22
Reviewing Challenges in the Diagnosis and Treatment of Lentigo Maligna and Lentigo-Maligna Melanoma. ( 27182482 )
2015
23
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. ( 24903264 )
2014
24
[Clinical utility of reflectance confocal microscopy for the non-invasive diagnosis of lentigo maligna melanoma]. ( 25112112 )
2014
25
Clinical usefulness of reflectance confocal microscopy in the management of facial lentigo maligna melanoma. ( 24657027 )
2014
26
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. ( 24934910 )
2014
27
Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre. ( 24958545 )
2014
28
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. ( 25394551 )
2014
29
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. ( 23647022 )
2013
30
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota. ( 24164856 )
2013
31
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma. ( 23623186 )
2013
32
Clinical Usefulness of Reflectance Confocal Microscopy in the Management of Facial Lentigo Maligna Melanoma. ( 23642470 )
2013
33
Grenz ray treatment of lentigo maligna and early lentigo maligna melanoma. ( 22030019 )
2012
34
Surgical and histologic pitfalls in the management of lentigo maligna melanoma. ( 22370566 )
2012
35
Risk factors for lentigo maligna melanoma compared with superficial spreading melanoma: a case-control study in Australia. ( 22004881 )
2012
36
Geometric staged excision for the treatment of lentigo maligna and lentigo maligna melanoma: a long-term experience with literature review. ( 22782151 )
2012
37
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. ( 22175303 )
2012
38
Dermoscopy of lentigo maligna melanoma: report of 125 cases. ( 22404578 )
2012
39
The perimeter technique in the surgical treatment of lentigo maligna and lentigo maligna melanoma. ( 22683018 )
2012
40
Treatment of extensive lentigo maligna melanoma of the scalp by brachytherapy moulage technique. ( 20874783 )
2011
41
Lentigo maligna: melanoma in situ on chronically sun-damaged skin. ( 21732771 )
2011
42
Underlying amelanotic lentigo maligna melanoma uncovered after a severe blistering sunburn. ( 20919599 )
2010
43
Lentigo maligna melanoma--the review. ( 21305747 )
2010
44
Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. ( 18963287 )
2009
45
Lentigo maligna melanoma with folliculotropism: dermoscopic features during rapid progression. ( 19528438 )
2009
46
Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience. ( 19952650 )
2009
47
Reflectance confocal microscopy of facial lentigo maligna and lentigo maligna melanoma: a preliminary study. ( 19566662 )
2009
48
Matrix metalloproteinases 2 and 9 in lentigo maligna melanoma. ( 19528914 )
2009
49
Identification of progenitor cancer stem cell in lentigo maligna melanoma. ( 18727808 )
2008
50
Staged excision for lentigo maligna and lentigo maligna melanoma: A retrospective analysis of 117 cases. ( 18029055 )
2008

Variations for Lentigo Maligna Melanoma

Expression for Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for Lentigo Maligna Melanoma

Pathways related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.45 MITF MMP2 MMP9
2
Show member pathways
12.38 MITF MMP2 MMP9
3
Show member pathways
11.57 MMP2 MMP9
4 11.52 MMP2 MMP9
5 11.41 MMP2 MMP9
6 11.34 MMP2 MMP9
7 11.32 MMP2 MMP9
8 11.29 MMP2 MMP9
9
Show member pathways
11.28 MMP2 MMP9
10 11.24 MMP2 MMP9
11 11.11 MMP2 MMP9
12
Show member pathways
11.06 MMP2 MMP9
13 10.98 MC1R MITF
14 10.85 MMP2 MMP9
15 10.76 MMP2 MMP9
16 10.7 MITF MMP2 MMP9
17 10.57 MMP2 MMP9
18 10.32 MMP2 MMP9

GO Terms for Lentigo Maligna Melanoma

Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.4 MMP2 MMP9
2 extracellular matrix disassembly GO:0022617 9.37 MMP2 MMP9
3 collagen catabolic process GO:0030574 9.32 MMP2 MMP9
4 embryo implantation GO:0007566 9.26 MMP2 MMP9
5 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.16 MMP2 MMP9
6 pigmentation GO:0043473 8.96 MC1R MITF
7 endodermal cell differentiation GO:0035987 8.62 MMP2 MMP9

Sources for Lentigo Maligna Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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