LMM
MCID: LNT002
MIFTS: 38

Lentigo Maligna Melanoma (LMM)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Lentigo Maligna Melanoma

MalaCards integrated aliases for Lentigo Maligna Melanoma:

Name: Lentigo Maligna Melanoma 53 73
Hutchison Melanotic Freckle 53
Lmm 53

Classifications:



External Ids:

UMLS 73 C2739810

Summaries for Lentigo Maligna Melanoma

NIH Rare Diseases : 53 Lentigo maligna melanoma (LMM) is a type of skin cancer that usually develops in older, fair-skinned adults.  The average age of diagnosis is 65.  LMM is thought to be caused by a history of sun exposure to the affected area.  Treatment includes surgery to remove as much of the LMM as possible.

MalaCards based summary : Lentigo Maligna Melanoma, also known as hutchison melanotic freckle, is related to melanoma and vitiligo-associated multiple autoimmune disease susceptibility 1. An important gene associated with Lentigo Maligna Melanoma is MC1R (Melanocortin 1 Receptor), and among its related pathways/superpathways are Pathways in cancer and Glioma. The drugs Imiquimod and interferons have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and tongue, and related phenotypes are integument and pigmentation

Related Diseases for Lentigo Maligna Melanoma

Diseases related to Lentigo Maligna Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 melanoma 31.9 MC1R MITF MLANA
2 vitiligo-associated multiple autoimmune disease susceptibility 1 30.5 MC1R MITF
3 lentigines 10.8
4 basal cell carcinoma 1 10.4
5 basal cell carcinoma 10.4
6 nodular malignant melanoma 10.4
7 superficial spreading melanoma 10.4
8 keratosis, seborrheic 10.2
9 xeroderma pigmentosum, variant type 10.2
10 gastrointestinal stromal tumor 10.2
11 dermatomyositis 10.2
12 keratosis 10.2
13 squamous cell carcinoma 10.2
14 merkel cell carcinoma 10.2
15 acral lentiginous melanoma 10.2
16 lichen planus 10.2
17 actinic lichen planus 10.2
18 tièche-jadassohn nevus 10.2
19 gallbladder melanoma 10.1 MITF MLANA
20 pigmented basal cell carcinoma 10.1 MITF MLANA
21 actinic keratosis 10.1 MC1R MMP2
22 epithelioid cell melanoma 10.1 MITF MLANA
23 breast angiosarcoma 10.1 MITF MLANA
24 sarcomatoid squamous cell skin carcinoma 10.1 MITF MLANA
25 albinism 10.1 MC1R MITF
26 hypophosphatemic bone disease 10.0
27 rett syndrome 10.0
28 extracranial arteriovenous malformation 10.0 MMP2 MMP9
29 focal myositis 10.0 MMP2 MMP9
30 villous adenocarcinoma 10.0 MMP2 MMP9
31 spastic entropion 10.0 MMP2 MMP9
32 psammomatous meningioma 10.0 MMP2 MMP9
33 acute transverse myelitis 10.0 MMP2 MMP9
34 transverse myelitis 10.0 MMP2 MMP9
35 senile ectropion 10.0 MMP2 MMP9
36 internal hemorrhoid 10.0 MMP2 MMP9
37 ischemic colitis 10.0 MMP2 MMP9
38 light chain deposition disease 10.0 MMP2 MMP9
39 parotitis 10.0 MMP2 MMP9
40 klatskin's tumor 10.0 MMP2 MMP9
41 corneal ulcer 10.0 MMP2 MMP9
42 laryngeal disease 10.0 MMP2 MMP9
43 hypertensive heart disease 10.0 MMP2 MMP9
44 aortic aneurysm, familial thoracic 1 10.0 MMP2 MMP9
45 pneumothorax 10.0 MMP2 MMP9
46 adenomyosis 10.0 MMP2 MMP9
47 grade iii astrocytoma 10.0 MMP2 MMP9
48 aortic disease 10.0 MMP2 MMP9
49 varicose veins 10.0 MMP2 MMP9
50 inguinal hernia 10.0 MMP2 MMP9

Graphical network of the top 20 diseases related to Lentigo Maligna Melanoma:



Diseases related to Lentigo Maligna Melanoma

Symptoms & Phenotypes for Lentigo Maligna Melanoma

MGI Mouse Phenotypes related to Lentigo Maligna Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 MC1R MITF MLANA MMP9 S100B
2 pigmentation MP:0001186 8.8 MC1R MITF MLANA

Drugs & Therapeutics for Lentigo Maligna Melanoma

Drugs for Lentigo Maligna Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imiquimod Approved, Investigational Phase 3,Phase 2 99011-02-6 57469
2 interferons Phase 3,Phase 2
3 Immunologic Factors Phase 3,Phase 2
4 Adjuvants, Immunologic Phase 3,Phase 2
5 Interferon Inducers Phase 3,Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Relevance of Imiquimod as Neo-adjuvant Treatment to Reduce Excision Size and the Risk of Intralesional Excision in Lentigo Malignant of the Face Recruiting NCT01720407 Phase 3 Imiquimod cream + surgery;Placebo + surgery
2 Imiquimod to Detect Residual Lesions and Prevent Recurrence of Lentigo Maligna Active, not recruiting NCT01088737 Phase 2, Phase 3 Imiquimod
3 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
4 French Clinical Datbase of Melanoma Patients (RIC-Mel) Recruiting NCT03315468

Search NIH Clinical Center for Lentigo Maligna Melanoma

Genetic Tests for Lentigo Maligna Melanoma

Anatomical Context for Lentigo Maligna Melanoma

MalaCards organs/tissues related to Lentigo Maligna Melanoma:

41
Skin, Heart, Tongue

Publications for Lentigo Maligna Melanoma

Articles related to Lentigo Maligna Melanoma:

(show top 50) (show all 146)
# Title Authors Year
1
Impact of Dermoscopy and Reflectance Confocal Microscopy on the Histopathologic Diagnosis of Lentigo Maligna/Lentigo Maligna Melanoma. ( 29933314 )
2018
2
Staged margin-controlled excision (SMEX) for lentigo maligna melanoma in situ. ( 29936706 )
2018
3
Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma. ( 29430695 )
2018
4
Repair of a Complex Marginal Auricular Defect After Lentigo Maligna Melanoma Excision. ( 29933298 )
2018
5
Pigmented actinic lichen planus (PALP) mimicking lentigo maligna melanoma: Usefulness of in vivo reflectance confocal microscopy in diagnosis and follow-up. ( 29998176 )
2018
6
Amelanotic Lentigo Maligna Melanoma: Mohs Surgery as the Definitive Treatment of an Invisible Tumour. ( 28685596 )
2018
7
Development of Vitiligo-Like Depigmentation after Treatment of Lentigo Maligna Melanoma with 5% Imiquimod Cream. ( 30065586 )
2018
8
Serial excision and Imiquimod for lentigo maligna melanoma: a proposal for a combined treatment. ( 30251811 )
2018
9
The steadily growing problem of lentigo maligna and lentigo maligna melanoma in Australia: Population-based data on diagnosis and management. ( 30302753 )
2018
10
Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia. ( 30548854 )
2018
11
Correlation of Handheld Reflectance Confocal Microscopy With Radial Video Mosaicing for Margin Mapping of Lentigo Maligna and Lentigo Maligna Melanoma. ( 29049429 )
2017
12
Synchronous conjunctival melanoma and lentigo maligna melanoma. ( 28954115 )
2017
13
TIMPs expression in lentigo malignaA^lentigo maligna melanoma versus aged skin - a review of the literature and personal experience. ( 29250646 )
2017
14
Locally Recurrent Lentigo Maligna and Lentigo Maligna Melanoma: Characteristics and Time to Recurrence After Surgery. ( 28296789 )
2017
15
Lentigo maligna melanoma with a history of cosmetic treatment: Prevalence, surgical outcomes and considerations. ( 28555933 )
2017
16
Very Rare Amelanotic Lentigo Maligna Melanoma with Skull Roof Invasion. ( 28785332 )
2017
17
Comparison of MITF and Melan-A Immunohistochemistry During Mohs Surgery for Lentigo Maligna-Type Melanoma In Situ and Lentigo Maligna Melanoma. ( 26771682 )
2016
18
A systematic review on the role of imiquimod in lentigo maligna and lentigo maligna melanoma: need for standardization of treatment schedule and outcome measures. ( 27987308 )
2016
19
Extrafacial lentigo maligna melanoma is reported often in Australia, more so at lower latitudes. ( 26820786 )
2016
20
Epidemiology of Lentigo Maligna andA Lentigo Maligna Melanoma in theA Netherlands, 1989-2013. ( 27349862 )
2016
21
Hyperspectral imaging in detecting dermal invasion in lentigo maligna melanoma. ( 28012166 )
2016
22
Lifetime UV exposure and Lentigo Maligna Melanoma. ( 27925150 )
2016
23
Staged Excision for Lentigo Maligna and Lentigo Maligna Melanoma: Analysis of Surgical Margins and Long-term Recurrence in 68 Cases from a Single Practice. ( 27386048 )
2016
24
Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. ( 26050216 )
2015
25
Curative Electrochemotherapy in Lentigo Maligna Melanoma. ( 26861530 )
2015
26
Lentigo Maligna Melanoma With Local and Distant Blue Nevus-like Metastases. ( 25943243 )
2015
27
Reviewing Challenges in the Diagnosis and Treatment of Lentigo Maligna and Lentigo-Maligna Melanoma. ( 27182482 )
2015
28
Lentigo maligna and lentigo maligna melanoma: contemporary issues in diagnosis and management. ( 30190846 )
2015
29
Lentigo maligna and lentigo maligna melanoma as occupational skin diseases in a forestry worker with long-standing occupational UV-exposure. ( 24903264 )
2014
30
[Clinical utility of reflectance confocal microscopy for the non-invasive diagnosis of lentigo maligna melanoma]. ( 25112112 )
2014
31
Clinical usefulness of reflectance confocal microscopy in the management of facial lentigo maligna melanoma. ( 24657027 )
2014
32
Johnson square procedure for lentigo maligna and lentigo maligna melanoma. ( 24934910 )
2014
33
Clinicopathological characteristics of 270 patients with lentigo maligna and lentigo maligna melanoma: data from a German skin cancer centre. ( 24958545 )
2014
34
Delineating Margins of Lentigo Maligna (Melanoma) Using a Hyperspectral Imaging System. ( 25394551 )
2014
35
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population. ( 23647022 )
2013
36
Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota. ( 24164856 )
2013
37
Recurrent lentigo maligna melanoma commingling the tumour nests of a basal cell carcinoma. ( 23623186 )
2013
38
Clinical Usefulness of Reflectance Confocal Microscopy in the Management of Facial Lentigo Maligna Melanoma. ( 23642470 )
2013
39
Grenz ray treatment of lentigo maligna and early lentigo maligna melanoma. ( 22030019 )
2012
40
Surgical and histologic pitfalls in the management of lentigo maligna melanoma. ( 22370566 )
2012
41
Risk factors for lentigo maligna melanoma compared with superficial spreading melanoma: a case-control study in Australia. ( 22004881 )
2012
42
Geometric staged excision for the treatment of lentigo maligna and lentigo maligna melanoma: a long-term experience with literature review. ( 22782151 )
2012
43
KIT and BRAF mutational status in a patient with a synchronous lentigo maligna melanoma and a gastrointestinal stromal tumor. ( 22175303 )
2012
44
Dermoscopy of lentigo maligna melanoma: report of 125 cases. ( 22404578 )
2012
45
The perimeter technique in the surgical treatment of lentigo maligna and lentigo maligna melanoma. ( 22683018 )
2012
46
Treatment of extensive lentigo maligna melanoma of the scalp by brachytherapy moulage technique. ( 20874783 )
2011
47
Lentigo maligna: melanoma in situ on chronically sun-damaged skin. ( 21732771 )
2011
48
Underlying amelanotic lentigo maligna melanoma uncovered after a severe blistering sunburn. ( 20919599 )
2010
49
Lentigo maligna melanoma--the review. ( 21305747 )
2010
50
Atypical fibroxanthoma, lentigo maligna melanoma and squamous cell carcinoma arising in the site of a thermal burn treated with skin grafts. ( 18963287 )
2009

Variations for Lentigo Maligna Melanoma

Expression for Lentigo Maligna Melanoma

Search GEO for disease gene expression data for Lentigo Maligna Melanoma.

Pathways for Lentigo Maligna Melanoma

Pathways related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.45 MITF MMP2 MMP9
2
Show member pathways
12.38 MITF MMP2 MMP9
3
Show member pathways
11.57 MMP2 MMP9
4 11.52 MMP2 MMP9
5 11.41 MMP2 MMP9
6 11.34 MMP2 MMP9
7 11.32 MMP2 MMP9
8 11.29 MMP2 MMP9
9
Show member pathways
11.28 MMP2 MMP9
10 11.24 MMP2 MMP9
11 11.11 MMP2 MMP9
12
Show member pathways
11.06 MMP2 MMP9
13 10.98 MC1R MITF
14 10.85 MMP2 MMP9
15 10.76 MMP2 MMP9
16 10.7 MITF MMP2 MMP9
17 10.57 MMP2 MMP9
18 10.32 MMP2 MMP9

GO Terms for Lentigo Maligna Melanoma

Biological processes related to Lentigo Maligna Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ephrin receptor signaling pathway GO:0048013 9.4 MMP2 MMP9
2 extracellular matrix disassembly GO:0022617 9.37 MMP2 MMP9
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.32 MMP2 MMP9
4 embryo implantation GO:0007566 9.26 MMP2 MMP9
5 pigmentation GO:0043473 9.16 MC1R MITF
6 collagen catabolic process GO:0030574 8.96 MMP2 MMP9
7 endodermal cell differentiation GO:0035987 8.62 MMP2 MMP9

Sources for Lentigo Maligna Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....