MCID: LPR001
MIFTS: 49

Lepromatous Leprosy

Categories: Endocrine diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Lepromatous Leprosy

MalaCards integrated aliases for Lepromatous Leprosy:

Name: Lepromatous Leprosy 12 15 17 32
Leprosy, Lepromatous 44 70
Leprosy Lepromatous 54
Type L Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10887
ICD9CM 34 030.0
MeSH 44 D015440
SNOMED-CT 67 21560005
ICD10 32 A30.5
UMLS 70 C0023348

Summaries for Lepromatous Leprosy

Disease Ontology : 12 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary : Lepromatous Leprosy, also known as leprosy, lepromatous, is related to tuberculoid leprosy and erythema nodosum. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clofazimine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and liver, and related phenotypes are hematopoietic system and cellular

Wikipedia : 73 Lepromatous leprosy is a form of leprosy characterized by pale macules in the... more...

Related Diseases for Lepromatous Leprosy

Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 605)
# Related Disease Score Top Affiliating Genes
1 tuberculoid leprosy 31.2 TNF TLR2 IL2 IL10 IFNG
2 erythema nodosum 31.0 VDR TNF MIF IL10 IFNG ICAM1
3 leprosy 3 30.8 VDR TNF TLR2 IL4 IL2 IL12RB2
4 keratitis, hereditary 30.5 TNF TLR2 MIF IL10
5 skin sarcoidosis 30.5 TNF IL2 IFNG
6 neurosyphilis 30.4 TLR2 IL10
7 histoplasmosis 30.4 TNF IL12RB1 IFNG
8 exanthem 30.3 TNF IL2 IL18 IL10 IFNG
9 oral tuberculosis 30.3 TNF IL2 IFNG
10 tertiary syphilis 30.3 TNF IL10
11 orchitis 30.2 TNF IL2 IL10
12 neuritis 30.2 TNF MIF IL4 IL10 IFNG
13 mumps 30.1 TNF IL2 IL12RB2 IL10 IFNG
14 scleritis 30.1 TNF IL4 IFNG
15 tetanus 30.1 TNF IL4 IL2 IL10 IFNG
16 actinic prurigo 30.1 TNF ICAM1 CD2
17 chronic spontaneous urticaria 30.0 TNF IL2 IL18 IFNG
18 mastitis 30.0 TLR2 IL18 ICAM1
19 chronic granulomatous disease 30.0 TNF IL18 IFNG IDO1 ICAM1
20 pemphigus 30.0 TNF IL4 IL10
21 herpes zoster 30.0 TNF TLR2 IL2 IL10 IFNG
22 mixed connective tissue disease 29.9 TNF IL10 IFNG HSPD1
23 extrapulmonary tuberculosis 29.9 VDR TLR2 IL10 IFNGR1 IFNG
24 septic arthritis 29.9 TNF TLR2 IFNG CCL18
25 melioidosis 29.9 TNF TLR2 IL18 IL10 IFNG
26 pemphigoid 29.9 TNF IL4 IFNG
27 alopecia 29.9 VDR TNF IL4 IL2 IFNG
28 hemophagocytic lymphohistiocytosis 29.9 TNF IL18 IL10 IFNGR1 IFNG
29 nocardiosis 29.8 TNF IL12RB2 IL12RB1 IFNG HSPD1
30 ige responsiveness, atopic 29.8 IL4 IL10 IFNG
31 urticaria 29.8 TNF IL4 IL18 IL10
32 periapical granuloma 29.8 TLR2 IL4 IL2
33 hypereosinophilic syndrome 29.8 IL4 IL2 IL10 IFNG
34 rhinitis 29.7 TNF IL4 IL10 IFNG ICAM1
35 cryptococcosis 29.7 TNF IL4 IL10 IFNG
36 hepatitis a 29.7 TNF IL4 IL10 IFNG
37 mucocutaneous leishmaniasis 29.7 TNF IL4 IL2 IL10 IFNG
38 primary biliary cholangitis 29.7 VDR IL12RB2 IL12RB1 HSPD1
39 basal cell carcinoma 29.7 VDR TNF IL2 IL10 ICAM1
40 cutaneous leishmaniasis 29.7 TNF TLR2 IL4 IL2 IL10 IFNG
41 allergic contact dermatitis 29.6 TNF IL4 IL10 IFNG ICAM1
42 lymphopenia 29.6 IL4 IL2 IL10 IFNG
43 allergic disease 29.6 TNF TLR2 IL4 IL2 IL18 IL12RB1
44 leishmaniasis 29.5 TNF TLR2 IL4 IL2 IL12B IL10
45 pulmonary sarcoidosis 29.5 TNF IL2 IL18 IL12RB1 IFNG ICAM1
46 human immunodeficiency virus type 1 29.5 TNF IL2 IL12B IL10 IFNG IDO1
47 stomatitis 29.5 TNF IL4 IL2 IL10 IFNG
48 chickenpox 29.4 TNF IL4 IL2 IL10 IFNG
49 myasthenia gravis 29.4 TNF IL4 IL2 IL10 IFNG
50 peripheral nervous system disease 29.4 TNF IL4 IL2 IL10 IFNG

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to Lepromatous Leprosy

Symptoms & Phenotypes for Lepromatous Leprosy

MGI Mouse Phenotypes related to Lepromatous Leprosy:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 HSPD1 ICAM1 IDO1 IFNG IFNGR1 IL10
2 cellular MP:0005384 10.32 HSPD1 ICAM1 IDO1 IFNG IFNGR1 IL10
3 homeostasis/metabolism MP:0005376 10.31 ICAM1 IDO1 IFNG IFNGR1 IL10 IL12B
4 cardiovascular system MP:0005385 10.3 HSPD1 ICAM1 IDO1 IFNG IFNGR1 IL10
5 immune system MP:0005387 10.28 ICAM1 IDO1 IFNG IFNGR1 IL10 IL12B
6 digestive/alimentary MP:0005381 10.27 ICAM1 IFNG IFNGR1 IL10 IL12B IL12RB2
7 endocrine/exocrine gland MP:0005379 10.18 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
8 integument MP:0010771 10.11 HSPD1 ICAM1 IFNG IFNGR1 IL10 IL12RB1
9 liver/biliary system MP:0005370 9.92 IFNG IFNGR1 IL10 IL12RB2 IL2 IL4
10 muscle MP:0005369 9.91 HSPD1 ICAM1 IDO1 IFNG IL10 IL18
11 neoplasm MP:0002006 9.85 ICAM1 IFNG IFNGR1 IL10 IL12B IL12RB2
12 nervous system MP:0003631 9.7 HSPD1 ICAM1 IFNG IFNGR1 IL10 IL18
13 respiratory system MP:0005388 9.23 HSPD1 IFNG IL10 IL12B IL2 IL4

Drugs & Therapeutics for Lepromatous Leprosy

Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
2 Anti-Bacterial Agents Phase 4
3 Anti-Inflammatory Agents Phase 4
4 Vitamins Phase 4
5 Anti-Infective Agents Phase 4
6
Acetylcholine Approved, Investigational 51-84-3 187
7
Nitroprusside Approved, Investigational 15078-28-1 11963622
8
Nitric Oxide Approved 10102-43-9 145068
9 Neurotransmitter Agents
10 Pharmaceutical Solutions
11 Vasodilator Agents
12 Cholinergic Agents
13 Antihypertensive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on ENL Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo
2 Observation of Microcirculation Impairment in Patients With Lepromatous Leprosy Using Orthogonal Polarization Spectral (OPS) Imaging and Laser Doppler Iontophoresis Completed NCT02085317 acetylcholine Iontophoresis;sodium nitroprusside Iontophoresis

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Clofazimine
Dapsone

Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

Anatomical Context for Lepromatous Leprosy

MalaCards organs/tissues related to Lepromatous Leprosy:

40
Skin, Bone, Liver, T Cells, Heart, Eye, Lung

Publications for Lepromatous Leprosy

Articles related to Lepromatous Leprosy:

(show top 50) (show all 2591)
# Title Authors PMID Year
1
Abnormalities in intracellular processing and expression of interferon-gamma receptor in adherent cells from lepromatous leprosy patients. 54 61
20039824 2010
2
Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil. 61 54
19058987 2009
3
Tryptophan aspartate-containing coat protein (CORO1A) suppresses Toll-like receptor signalling in Mycobacterium leprae infection. 54 61
19438603 2009
4
Recovery of IFN-gamma levels in PBMCs from lepromatous leprosy patients through the synergistic actions of the cytokines IL-12 and IL-18. 54 61
18708162 2008
5
Inhibition of apoptosis, activation of NKT cell and upregulation of CD40 and CD40L mediated by M. leprae antigen(s) combined with Murabutide and Trat peptide in leprosy patients. 54 61
18008143 2008
6
TLR2 Arg677Trp polymorphism in leprosy: revisited. 54 61
15726416 2005
7
Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation. 61 54
15270740 2004
8
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. 61 54
12743710 2003
9
Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling. 54 61
12646604 2003
10
A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. 61 54
12445799 2002
11
Signaling lymphocytic activation molecule expression and regulation in human intracellular infection correlate with Th1 cytokine patterns. 54 61
11698444 2001
12
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. 61 54
11476982 2001
13
The effect of antigen presenting cells on the cytokine profiles of stable and reactional lepromatous leprosy patients. 61 54
11163869 2000
14
Dysregulation of IL-4 expression in lepromatous leprosy patients with and without erythema nodosum leprosum. 54 61
11201870 2000
15
Co-stimulatory signals increase the reactivity of gammadelta T cells towards mycobacterial antigens. 54 61
10844525 2000
16
Immunological cytokine correlates of protective immunity and pathogenesis in leprosy. 54 61
10736116 2000
17
Cytokine mRNA expression in leprosy: a possible role for interferon-gamma and interleukin-12 in reactions (RR and ENL). 54 61
10564558 1999
18
Addiction of anti-CD28 antibodies restores PBMC proliferation and IFN-gamma production in lepromatous leprosy patients. 61 54
10574615 1999
19
Serum IL-1ra is elevated in lepromatous leprosy patients. 54 61
10575408 1999
20
Immunochemotherapy with interferon-gamma and multidrug therapy for multibacillary leprosy. 54 61
10206118 1999
21
Lepromatous leprosy patients show T helper 1-like cytokine profile with differential expression of interleukin-10 during type 1 and 2 reactions. 61 54
9893041 1998
22
Cytokines in leprosy, I. Serum cytokine profile in leprosy. 54 61
9802682 1998
23
Rare transcripts of interferon-gamma detected in lepromatous leprosy cases. 54 61
9614846 1998
24
Production of host-protective (IFN-gamma), host-impairing (IL-10, IL-13) and inflammatory (TNF-alpha) cytokines by PBMC from leprosy patients stimulated with mycobacterial antigens. 61 54
9649657 1998
25
Recombinant interleukin-2 in lepromatous leprosy lesions: immunological and microbiological consequences. 54 61
9425693 1997
26
Effect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy. 61 54
9207756 1997
27
Ability of lymphokine-activated killer cells to lyse mycobacteria-infected cells. 54 61
9447253 1997
28
Restoration of proliferative response to M. leprae antigens in lepromatous T cells against candidate antileprosy vaccines. 61 54
8862259 1996
29
Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy. 61 54
8719110 1995
30
Does thalidomide affect IL-2 response and production? 61 54
7635184 1995
31
IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4+ T cells through an effect on antigen-presenting cells. 61 54
7876534 1995
32
Interferon-gamma and host antimicrobial defense: current and future clinical applications. 54 61
7977435 1994
33
Definition of a human suppressor T-cell epitope. 61 54
7524076 1994
34
Th1-Th2 paradigm: insights from leprosy. 54 61
8006444 1994
35
Clinical applications of cytokines. 61 54
7971820 1994
36
Effect of recombinant interferon gamma administration on lesional monocytes/macrophages in lepromatous leprosy patients. 54 61
8396615 1993
37
Development of giant reaction in response to PPD skin test in lepromatous leprosy patients. 61 54
8371029 1993
38
Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. 54 61
8482851 1993
39
Lepromatous leprosy treated with recombinant interferon gamma: cutaneous histologic changes. 54 61
1428437 1992
40
Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES. 54 61
1354834 1992
41
Prolonged treatment with recombinant interferon gamma induces erythema nodosum leprosum in lepromatous leprosy patients. 61 54
1588290 1992
42
Long-term follow up of lepromatous leprosy patients receiving intralesional recombinant gamma-interferon. 61 54
1602206 1992
43
Rational immunotherapy with interleukin 2. 61 54
1368227 1992
44
Leprosy. 54 61
1730174 1992
45
Stigma variations: observations on suppressor T cells and leprosy. 61 54
1534241 1992
46
Delipidified cell components of Mycobacterium leprae and its applications. 54 61
1804891 1991
47
The systemic influence of recombinant interleukin 2 on the manifestations of lepromatous leprosy. 54 61
2007862 1991
48
In vivo administration of low-dose human interleukin-2 induces lymphokine-activated killer cells for enhanced cytolysis in vitro. 61 54
1988157 1991
49
Widespread intradermal accumulation of mononuclear leukocytes in lepromatous leprosy patients treated systemically with recombinant interferon gamma. 61 54
2121891 1990
50
Immunohistologic assessment of cytokine production of infiltrating cells in various forms of leprosy. 61 54
2121040 1990

Variations for Lepromatous Leprosy

Expression for Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for Lepromatous Leprosy

Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 TNF TLR2 MIF IL4 IL2 IL18
2
Show member pathways
13.89 TNF IL4 IL2 IL18 IL12RB2 IL12RB1
3
Show member pathways
13.71 TNF MIF IL4 IL2 IL18 IL12RB2
4
Show member pathways
13.56 TNF IL4 IL2 IL18 IL12RB2 IL12RB1
5
Show member pathways
13.5 TNF TLR2 IL4 IL2 IL18 IL12RB2
6
Show member pathways
13.44 TNF IL4 IL2 IL18 IL12RB2 IL12RB1
7
Show member pathways
13.41 TNF IL4 IL2 IL18 IL12RB2 IL12RB1
8
Show member pathways
13.3 TNF TLR2 IL2 IL18 IL12B IL10
9
Show member pathways
12.98 TNF IL4 IL2 IL12B IL10 IFNG
10 12.96 IL4 IL2 IL12RB2 IL12RB1 IL12B IFNGR1
11
Show member pathways
12.95 TNF TLR2 IL2 IL18 IL12B IFNGR1
12
Show member pathways
12.87 TNF TLR2 IL4 IL2 IFNGR1 IFNG
13 12.83 TNF TLR2 IL12B IFNGR1 IFNG
14
Show member pathways
12.75 TNF TLR2 IL4 IL2 IL10 IFNGR1
15
Show member pathways
12.73 TNF IL2 IL18 IL12RB1 IL12B IL10
16
Show member pathways
12.71 TNF IL10 IFNGR1 IFNG ICAM1
17
Show member pathways
12.66 TNF IL4 IL2 IL18 IL12RB2 IL12RB1
18
Show member pathways
12.65 TNF IL4 IL2 IFNGR1 IFNG ICAM1
19 12.65 TNF TLR2 IL4 IL2 IL10 IFNG
20
Show member pathways
12.49 IL4 IL2 IL12RB2 IL12RB1 IL12B IL10
21
Show member pathways
12.44 TNF IL4 IL2 IFNG ICAM1
22
Show member pathways
12.44 TNF IL2 IL18 IL10 CCL18
23
Show member pathways
12.41 TNF IL4 IL2 IL18 IL12B IL10
24
Show member pathways
12.37 TNF TLR2 IL4 IFNG
25
Show member pathways
12.37 TNF TLR2 IL4 IL12B IL10 IFNGR1
26
Show member pathways
12.34 TNF MIF IFNGR1 IFNG
27
Show member pathways
12.31 TNF TLR2 IL4 IFNGR1 IFNG
28
Show member pathways
12.27 TNF IL2 IL12B IL10
29 12.24 TNF TLR2 IFNGR1 IFNG
30 12.23 VDR TNF TLR2 IL18 IL12B IL10
31
Show member pathways
12.23 TNF TLR2 IL4 IL2 IL18 IL12RB2
32 12.16 TNF IL2 IL18 IL10
33 12.16 TNF MIF IL4 IL2 IFNG ICAM1
34 12.13 TNF IL4 IL2 IL10 IFNG CD2
35 12.1 TNF IL4 IL18 IL12B IL10 ICAM1
36 12.09 TNF TLR2 IL12B IL10 IFNG
37
Show member pathways
12.07 IL4 IL2 IL18 IL12RB2 IL12RB1 IL12B
38 12.05 TNF TLR2 IL18 IFNG ICAM1
39
Show member pathways
12.03 TLR2 IL4 IL12RB1 IL12B IFNG
40 11.92 IL4 IL2 IFNG ICAM1
41 11.9 IL10 ICAM1 DEFB1
42
Show member pathways
11.89 IL12RB1 IL12B ICAM1
43
Show member pathways
11.88 TNF IL4 IL2 IFNG
44 11.87 TNF IL2 IL10 IFNG
45 11.85 TNF TLR2 IL4 IL10 ICAM1
46
Show member pathways
11.83 TNF MIF IL2 IFNG ICAM1
47 11.8 TNF IL12B IL10
48 11.78 TNF TLR2 IL18 IL12B HSPD1
49 11.71 TNF IL4 IL12B
50
Show member pathways
11.7 TNF IL2 IFNG

GO Terms for Lepromatous Leprosy

Cellular components related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 TNF MIF IL4 IL2 IL18 IL12B
2 external side of plasma membrane GO:0009897 9.73 TNF IL12RB2 IL12RB1 IL12B ICAM1 CD2
3 membrane raft GO:0045121 9.72 TNF TLR2 ICAM1 HSPD1 CD2
4 receptor complex GO:0043235 9.67 VDR IL12RB2 IL12RB1 IL12B
5 cell surface GO:0009986 9.5 TNF TLR2 MIF IL12B ICAM1 HSPD1
6 extracellular space GO:0005615 9.4 TNF MIF IL4 IL2 IL18 IL12B

Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 VDR TNF TLR2 IL4 IL2 IL18
2 negative regulation of apoptotic process GO:0043066 10.14 MIF IL4 IL2 IL10 HSPD1
3 positive regulation of gene expression GO:0010628 10.11 VDR TNF TLR2 IL4 IL18 IFNGR1
4 inflammatory response GO:0006954 10.09 TNF TLR2 MIF IL18 IDO1 CCL18
5 cell surface receptor signaling pathway GO:0007166 10.07 MIF IL12RB2 IL12B IFNG CD2
6 immune response GO:0006955 10.06 TNF TLR2 IL4 IL2 IL18 IL10
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.03 TNF MIF ICAM1 CCL18
8 leukocyte migration GO:0050900 10.01 TNF MIF ICAM1 CD2
9 cellular response to lipopolysaccharide GO:0071222 10 TNF IL12B IL10 ICAM1
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR2 IL18 ICAM1
11 response to lipopolysaccharide GO:0032496 9.97 TLR2 IL12RB2 IL10 IDO1 ICAM1 HSPD1
12 positive regulation of interleukin-6 production GO:0032755 9.93 TNF TLR2 IFNG HSPD1
13 response to organic substance GO:0010033 9.93 TNF IL12B IL10 HSPD1
14 cellular response to interferon-gamma GO:0071346 9.93 TLR2 IL12RB1 IL12B ICAM1 CCL18
15 response to insulin GO:0032868 9.92 TLR2 IL10 ICAM1
16 positive regulation of tumor necrosis factor production GO:0032760 9.91 TLR2 MIF IL12B IFNGR1 IFNG CD2
17 interferon-gamma-mediated signaling pathway GO:0060333 9.9 IFNGR1 IFNG ICAM1
18 response to glucocorticoid GO:0051384 9.9 TNF IL10 HSPD1
19 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.9 TNF TLR2 IL18 IL12B
20 positive regulation of T cell proliferation GO:0042102 9.89 IL4 IL2 IL12B
21 positive regulation of interleukin-8 production GO:0032757 9.89 TNF TLR2 CD2
22 positive regulation of cytokine production GO:0001819 9.89 TNF MIF IL10 IFNG
23 T cell activation GO:0042110 9.87 IL4 HSPD1 CD2
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TNF IFNG ICAM1
25 positive regulation of interleukin-10 production GO:0032733 9.86 TLR2 IL4 IL12B HSPD1
26 positive regulation of B cell proliferation GO:0030890 9.85 MIF IL4 IL2
27 positive regulation of chemokine production GO:0032722 9.85 TNF TLR2 IFNG
28 negative regulation of endothelial cell apoptotic process GO:2000352 9.85 IL4 IL10 ICAM1
29 positive regulation of interleukin-12 production GO:0032735 9.85 TLR2 IL12B IFNG IDO1 HSPD1
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR2 IL18
31 positive regulation of defense response to virus by host GO:0002230 9.83 IL4 IL12RB1 IL12B
32 positive regulation of osteoclast differentiation GO:0045672 9.81 TNF IL12B IFNG
33 positive regulation of activated T cell proliferation GO:0042104 9.81 IL2 IL18 IL12RB1 IL12B
34 positive regulation of amyloid-beta formation GO:1902004 9.8 TNF IFNGR1 IFNG
35 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.8 TNF IL4 IL2 IL18 IL12B IFNG
36 positive regulation of interleukin-17 production GO:0032740 9.79 IL2 IL18 IL12B
37 astrocyte activation GO:0048143 9.78 TNF IFNGR1 IFNG
38 natural killer cell activation GO:0030101 9.78 IL2 IL18 IL12B CD2
39 microglial cell activation GO:0001774 9.77 TNF TLR2 IL4 IFNGR1 IFNG
40 negative regulation of amyloid-beta clearance GO:1900222 9.76 TNF IFNGR1 IFNG
41 positive regulation of signaling receptor activity GO:2000273 9.75 IL10 IFNG
42 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.75 IFNGR1 IFNG
43 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.75 IL18 IL12B
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.75 IL4 IL10 IFNG
45 positive regulation of neuroinflammatory response GO:0150078 9.74 TNF IL18
46 positive regulation of T-helper 1 type immune response GO:0002827 9.74 IL12RB1 IL12B
47 response to molecule of bacterial origin GO:0002237 9.74 TLR2 IL10
48 T-helper 1 type immune response GO:0042088 9.74 IL18 IL12B
49 negative regulation of T-helper 17 cell differentiation GO:2000320 9.74 IL4 IL2
50 positive regulation of isotype switching to IgG isotypes GO:0048304 9.74 IL4 IL2

Molecular functions related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 IL4 IL2 IL12B IL10
2 cytokine receptor activity GO:0004896 9.46 IL12RB2 IL12RB1 IL12B IFNGR1
3 cytokine receptor binding GO:0005126 9.43 MIF IL4 IL12B
4 interleukin-12 receptor binding GO:0005143 9.37 IL12RB1 IL12B
5 cytokine activity GO:0005125 9.28 TNF MIF IL4 IL2 IL18 IL12B
6 cytokine binding GO:0019955 9.26 IL12RB2 IL12RB1 IL12B IFNGR1

Sources for Lepromatous Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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