MCID: LPR001
MIFTS: 54

Lepromatous Leprosy

Categories: Endocrine diseases, Eye diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Lepromatous Leprosy

MalaCards integrated aliases for Lepromatous Leprosy:

Name: Lepromatous Leprosy 12 15 17
Leprosy, Lepromatous 45 74
Leprosy Lepromatous 56
Type L Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10887
ICD9CM 36 030.0
MeSH 45 D015440
SNOMED-CT 69 21560005
ICD10 34 A30.5
UMLS 74 C0023348

Summaries for Lepromatous Leprosy

Disease Ontology : 12 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary : Lepromatous Leprosy, also known as leprosy, lepromatous, is related to leprosy 3 and tuberculoid leprosy. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clofazimine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 77 Lepromatous leprosy is a form of leprosy characterized by pale macules in the... more...

Related Diseases for Lepromatous Leprosy

Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 31.2 IFNG IL10 IL12RB2 IL2 TLR2 TNF
2 tuberculoid leprosy 30.9 IFNG IL10
3 tetanus 30.7 IFNG IL10 IL2
4 scleritis 30.6 IFNG TNF
5 mucocutaneous leishmaniasis 30.6 IL10 TNF
6 sporotrichosis 30.5 IFNG IL10
7 oral tuberculosis 30.5 IL2 TNF
8 herpes zoster 30.2 IFNG IL10 IL2
9 coccidioidomycosis 30.1 IFNGR1 IL10
10 hemophagocytic lymphohistiocytosis 30.1 IFNG IL10 TNF
11 melioidosis 30.1 IFNG IL10 TLR2 TNF
12 cutaneous leishmaniasis 30.1 IFNG IL10 TLR2 TNF
13 aspergillosis 30.1 IFNG IL10 TLR2 TNF
14 human immunodeficiency virus infectious disease 30.0 IFNG IL10 IL2 TNF
15 arthritis 30.0 IFNG IL10 MIF TNF
16 myasthenia gravis 30.0 IFNG IL10 IL2 TNF
17 contact dermatitis 29.9 ICAM1 IFNG IL10 TNF
18 leishmaniasis 29.9 IFNG IFNGR1 IL10 TLR2 TNF
19 systemic lupus erythematosus 29.7 ICAM1 IFNG IL10 IL2 TLR2 TNF
20 rheumatoid arthritis 28.8 ICAM1 IFNG IL10 IL2 MIF TLR2
21 pulmonary tuberculosis 28.6 IFNG IFNGR1 IL10 IL12RB1 IL2 TLR2
22 leprosy 1 11.7
23 hansen's disease 10.5
24 penicilliosis 10.5 TLR2 TNF
25 periapical periodontitis 10.5 TLR2 TNF
26 congenital cytomegalovirus 10.5 TLR2 TNF
27 haemophilus influenzae 10.5 TLR2 TNF
28 mycobacterium abscessus 10.5 TLR2 TNF
29 nontuberculous mycobacterial lung disease 10.5 TLR2 TNF
30 spondylarthropathy 10.5 TLR2 TNF
31 myositis fibrosa 10.5 IFNG TLR2
32 microscopic colitis 10.5 IFNG TNF
33 meconium aspiration syndrome 10.5 IFNG TNF
34 central nervous system vasculitis 10.4 IFNG TNF
35 filarial elephantiasis 10.4 IL10 TLR2
36 tuberculous peritonitis 10.4 IFNG TNF
37 soft tissue sarcoma 10.4 IFNG TNF
38 cow milk allergy 10.4 IL10 TNF
39 trachoma 10.4 IL10 TNF
40 trichuriasis 10.4 IL10 TNF
41 idiopathic achalasia 10.4 IL10 TNF
42 baylisascariasis 10.4 IFNG IL10
43 multicentric castleman disease 10.4 IFNG IL10
44 fungal meningitis 10.4 IFNG IL10
45 pericardial tuberculosis 10.4 IFNG IL10
46 peanut allergy 10.4 IFNG IL10
47 fascioliasis 10.4 IFNG IL10
48 burning mouth syndrome 10.4 IL2 TNF
49 atopic keratoconjunctivitis 10.4 IFNG IL2
50 gaucher disease, type ii 10.4 IL10 IL2

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to Lepromatous Leprosy

Symptoms & Phenotypes for Lepromatous Leprosy

MGI Mouse Phenotypes related to Lepromatous Leprosy:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.17 ICAM1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
2 cardiovascular system MP:0005385 10.16 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
3 cellular MP:0005384 10.15 ICAM1 IFNG IFNGR1 IL10 IL2 MIF
4 homeostasis/metabolism MP:0005376 10.14 ICAM1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
5 behavior/neurological MP:0005386 10.13 IFNG IFNGR1 IL10 IL12RB1 IL2 TLR2
6 digestive/alimentary MP:0005381 10.13 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
7 endocrine/exocrine gland MP:0005379 10.11 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
8 immune system MP:0005387 10.11 ICAM1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
9 integument MP:0010771 9.87 ICAM1 IFNG IFNGR1 IL10 TLR2 TNF
10 liver/biliary system MP:0005370 9.8 IFNG IFNGR1 IL10 IL12RB2 IL2 TLR2
11 muscle MP:0005369 9.63 ICAM1 IFNG IL10 TLR2 TNF VDR
12 neoplasm MP:0002006 9.61 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
13 nervous system MP:0003631 9.23 ICAM1 IFNG IFNGR1 IL10 MIF TLR2

Drugs & Therapeutics for Lepromatous Leprosy

Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
2 Anti-Bacterial Agents Phase 4
3 Anti-Inflammatory Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Vitamins Phase 4
6
Nitroprusside Approved, Investigational Not Applicable 15078-28-1 11963622
7
Nitric Oxide Approved Not Applicable 10102-43-9 145068
8
Acetylcholine Approved, Investigational Not Applicable 51-84-3 187
9 Antihypertensive Agents Not Applicable
10 Pharmaceutical Solutions Not Applicable
11 Neurotransmitter Agents Not Applicable
12 Nitric Oxide Donors Not Applicable
13 Cholinergic Agents Not Applicable
14 Vasodilator Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo
2 Microcirculatory Impairment in Patients With Leprosy Completed NCT02085317 Not Applicable acetylcholine Iontophoresis;sodium nitroprusside Iontophoresis
3 Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy No longer available NCT00852345 clofazamine

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

Anatomical Context for Lepromatous Leprosy

MalaCards organs/tissues related to Lepromatous Leprosy:

42
Skin, T Cells, Monocytes, Testes, Liver, Bone, Eye

Publications for Lepromatous Leprosy

Articles related to Lepromatous Leprosy:

(show top 50) (show all 1008)
# Title Authors Year
1
Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas. ( 30666944 )
2019
2
Does histoid leprosy represent a locally hyperimmune variant of lepromatous leprosy? ( 30778548 )
2019
3
Lepromatous leprosy masquerading as anetoderma in a boy. ( 30829294 )
2019
4
Borderline lepromatous leprosy masking as tinea versicolor. ( 30891732 )
2019
5
Increased CD5+ B-cells are associated with autoimmune phenomena in lepromatous leprosy patients. ( 30904499 )
2019
6
Visibly enlarged peripheral nerves in lepromatous leprosy. ( 30910939 )
2019
7
Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas. ( 29664381 )
2018
8
Erythema nodosum leprosum presenting as sweet's syndrome-like reaction in a borderline lepromatous leprosy patient. ( 29900900 )
2018
9
Serum Levels of Migration Inhibitory Factor (MIF) and <i>In Situ</i> Expression of MIF and Its Receptor CD74 in Lepromatous Leprosy Patients: A Preliminary Report. ( 29487601 )
2018
10
Systemic nocardiosis in a lepromatous leprosy patient with type 2 reaction. ( 29520868 )
2018
11
Borderline Lepromatous Leprosy: Uncommon Clinical Presentation. ( 30211733 )
2018
12
Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas. ( 29048278 )
2017
13
Lepromatous leprosy-negative images giving the diagnostic clue. ( 29323094 )
2017
14
Lepromatous leprosy with Lucio's phenomenon. ( 28660648 )
2017
15
Th17 Response of Borderline-Lepromatous Leprosy Inhibits Rash Manifestation of Dapsone Hypersensitivity Syndrome: Case Report. ( 28937434 )
2017
16
The Armadillo Factor: Lepromatous Leprosy. ( 28623172 )
2017
17
Infiltration in a child's face due to borderline lepromatous leprosy. ( 29160527 )
2017
18
Cytological Diagnosis of Primary Cutaneous Aspergillosis Masquerading as Lipoma in a Known Case of Lepromatous Leprosy. ( 28658789 )
2017
19
Primary Cutaneous Histoplasmosis Masquerading as Lepromatous Leprosy. ( 28273974 )
2017
20
Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis. ( 28419120 )
2017
21
Lepromatous leprosy in a renal transplant recipient. ( 28449328 )
2017
22
Two Cases of Lepromatous Leprosy from Exposure to Armadillos in Florida. ( 29139372 )
2017
23
Lepromatous leprosy simulating rheumatoid arthritis - Report of a neglected disease. ( 29186255 )
2017
24
Borderline lepromatous leprosy, Erythema Nodosum Leprosum and a generalized varicella zoster virus infection: a deadly combination. ( 28319279 )
2017
25
Leg ulcer in lepromatous leprosy - Case report. ( 27828650 )
2016
26
A Rare Case of Coexistence of Borderline Lepromatous Leprosy with Tuberculosis Verrucosa Cutis. ( 28003920 )
2016
27
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. ( 27891733 )
2016
28
Primary oral tuberculosis in a patient with lepromatous leprosy: Diagnostic dilemma. ( 26927999 )
2016
29
Association between STR -794 CATT5-8 and SNP -173 G/C polymorphisms in the MIF gene and Lepromatous Leprosy in Mestizo patients of western Mexico. ( 27426952 )
2016
30
Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients. ( 27764137 )
2016
31
Borderline Lepromatous Leprosy: A Case to Remember. ( 26888945 )
2016
32
Mycobacterium leprae-Infected Macrophages Preferentially Primed Regulatory T Cell Responses and Was Associated with Lepromatous Leprosy. ( 26751388 )
2016
33
Hertoghe sign: a hallmark of lepromatous leprosy. ( 27026695 )
2016
34
Crusted scabies in a patient with lepromatous leprosy. ( 27183357 )
2016
35
Autochthonous lepromatous leprosy in a Spanish woman with burns on both feet and skin lesions. ( 30226357 )
2016
36
Activation and cytokine profile of monocyte derived dendritic cells in leprosy: in vitro stimulation by sonicated Mycobacterium leprae induces decreased level of IL-12p70 in lepromatous leprosy. ( 26222022 )
2015
37
A case of lepromatous leprosy with co-existing tuberculosis verrucosa cutis (TVC). ( 26502689 )
2015
38
A Lepromatous Leprosy Patient with Permanent Disability. ( 26537774 )
2015
39
Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy. ( 25970602 )
2015
40
Dapsone hypersensitivity syndrome in a lepromatous leprosy patient--A Case Report. ( 26502691 )
2015
41
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man. ( 26251526 )
2015
42
A case of secondary syphilis with HIV, resembling borderline lepromatous leprosy. ( 26692613 )
2015
43
Disseminated cutaneous BCG infection following BCG immunotherapy in patients with lepromatous leprosy. ( 26502690 )
2015
44
Lymph node abscess and cardiac involvement in a patient with nodular lepromatous leprosy (LL) with erythema nodosum leprosum (ENL): a rare occurrence. ( 26065155 )
2015
45
Pulmonary Tuberculosis and Lepromatous Leprosy Coinfection. ( 26504603 )
2015
46
Diffuse Lepromatous Leprosy Due to Mycobacterium lepromatosis in Quintana Roo, Mexico. ( 26311856 )
2015
47
What is your diagnosis? lepromatous leprosy. ( 25671446 )
2015
48
Lepromatous leprosy: An Unusual Presentation. ( 26591848 )
2015
49
Persistent serpentine supravenous hyperpigmented eruption in lepromatous leprosy after minocycline. ( 26502692 )
2015
50
Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy. ( 26327983 )
2015

Variations for Lepromatous Leprosy

Expression for Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for Lepromatous Leprosy

Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 ICAM1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
2
Show member pathways
13.61 CD2 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
3
Show member pathways
13.46 CD2 ICAM1 IFNG IFNGR1 IL10 IL12RB1
4
Show member pathways
13.37 CD2 IL10 IL12RB1 IL12RB2 IL2 TLR2
5
Show member pathways
13.3 ICAM1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
6
Show member pathways
13.25 CD2 IL10 IL12RB1 IL12RB2 IL2 TNF
7
Show member pathways
13.17 IFNG IFNGR1 IL10 IL2 TLR2 TNF
8 12.82 IFNG IFNGR1 IL12RB1 IL12RB2 IL2
9
Show member pathways
12.71 ICAM1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2
10
Show member pathways
12.58 IFNG IL10 IL12RB1 IL2 TNF
11
Show member pathways
12.57 ICAM1 IFNG IFNGR1 IL2 TLR2 TNF
12
Show member pathways
12.56 IFNG IFNGR1 IL10 IL12RB1 IL12RB2 IL2
13 12.54 CD2 IFNG IL10 IL2 TLR2 TNF
14
Show member pathways
12.51 ICAM1 IFNG IFNGR1 IL2 TNF
15
Show member pathways
12.42 IFNG IL10 IL2 TNF
16
Show member pathways
12.38 IFNG IFNGR1 IL10 IL12RB1 IL12RB2 IL2
17
Show member pathways
12.33 ICAM1 IFNG IL2 TNF
18
Show member pathways
12.3 IFNG IFNGR1 MIF TNF
19
Show member pathways
12.25 IFNG IFNGR1 IL10 TLR2 TNF
20
Show member pathways
12.23 IFNG IL10 IL2 TNF
21
Show member pathways
12.19 IFNG IFNGR1 TLR2 TNF
22 12.19 IFNG IFNGR1 TLR2 TNF
23 12.16 IFNG IFNGR1 IL10 TLR2 TNF VDR
24
Show member pathways
12.14 IL10 IL2 TNF
25
Show member pathways
12.14 IFNG IFNGR1 TNF
26
Show member pathways
12.1 IFNG IFNGR1 IL10 IL12RB1 IL12RB2 IL2
27
Show member pathways
12.07 CD2 ICAM1 IFNG IFNGR1 IL10 IL2
28 12.05 ICAM1 IFNG TNF
29 12.01 IFNG IFNGR1 TNF
30
Show member pathways
12 IFNG TLR2 TNF
31 12 ICAM1 IFNG IL2 MIF TNF
32
Show member pathways
11.99 IFNG IL12RB1 IL12RB2 IL2
33 11.96 CD2 IFNG IL10 IL2 TNF
34 11.95 ICAM1 IL10 TNF
35 11.91 IFNG IL10 TLR2 TNF
36 11.88 ICAM1 IFNG TLR2 TNF
37 11.8 ICAM1 IFNG IL2
38 11.78 IFNG IL10 IL2 TNF
39
Show member pathways
11.77 IFNG IL2 TNF
40 11.75 IFNG IL10 IL2 TNF
41 11.68 IFNG IFNGR1 IL10 IL12RB1 IL12RB2 IL2
42
Show member pathways
11.66 IFNG IL2 TNF
43
Show member pathways
11.6 ICAM1 IFNG IL2 MIF TNF
44 11.58 IFNG IL2 TNF
45
Show member pathways
11.57 IFNG IFNGR1 TNF
46 11.56 ICAM1 IL10 TNF
47 11.54 IFNG IL2 TNF
48 11.54 IFNG TLR2 TNF
49 11.54 IFNG IL10 IL12RB1 IL12RB2 IL2 TNF
50 11.52 IFNG IL10 IL12RB2 IL2

GO Terms for Lepromatous Leprosy

Cellular components related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 CD2 ICAM1 IFNGR1 IL12RB2 TLR2 TNF
2 cell surface GO:0009986 9.35 CD2 ICAM1 MIF TLR2 TNF
3 external side of plasma membrane GO:0009897 9.02 CD2 ICAM1 IL12RB1 IL12RB2 TNF

Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 IFNG TLR2 TNF VDR
2 inflammatory response GO:0006954 9.93 IL10 MIF TLR2 TNF
3 immune response GO:0006955 9.93 IFNG IL10 IL2 TLR2 TNF
4 cell surface receptor signaling pathway GO:0007166 9.89 CD2 IFNG IL12RB2 MIF
5 regulation of signaling receptor activity GO:0010469 9.89 IFNG IL10 IL2 MIF TNF
6 cellular response to lipopolysaccharide GO:0071222 9.85 ICAM1 IL10 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 ICAM1 TLR2 TNF
8 leukocyte migration GO:0050900 9.81 CD2 ICAM1 MIF TNF
9 response to virus GO:0009615 9.8 IFNG IFNGR1 TNF
10 cellular response to interferon-gamma GO:0071346 9.79 ICAM1 IL12RB1 TLR2
11 positive regulation of inflammatory response GO:0050729 9.78 IL2 TLR2 TNF
12 positive regulation of protein phosphorylation GO:0001934 9.78 IFNG IL2 MIF TNF
13 response to insulin GO:0032868 9.76 ICAM1 IL10 TLR2
14 interferon-gamma-mediated signaling pathway GO:0060333 9.75 ICAM1 IFNG IFNGR1
15 positive regulation of tumor necrosis factor production GO:0032760 9.7 CD2 MIF TLR2
16 natural killer cell activation GO:0030101 9.69 CD2 IL2
17 positive regulation of interleukin-8 production GO:0032757 9.69 TLR2 TNF
18 regulation of synapse organization GO:0050807 9.69 IL10 TNF
19 positive regulation of activated T cell proliferation GO:0042104 9.68 IL12RB1 IL2
20 positive regulation of interleukin-12 production GO:0032735 9.68 IFNG TLR2
21 positive regulation of protein complex assembly GO:0031334 9.68 IFNG TNF
22 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
23 positive regulation of chemokine production GO:0032722 9.67 TLR2 TNF
24 response to lipopolysaccharide GO:0032496 9.67 ICAM1 IL10 IL12RB2 TLR2
25 microglial cell activation GO:0001774 9.66 TLR2 TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG TNF
27 regulation of regulatory T cell differentiation GO:0045589 9.65 IFNG IL2
28 negative regulation of growth of symbiont in host GO:0044130 9.65 IL10 TNF
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL10 TNF
30 positive regulation of interleukin-8 secretion GO:2000484 9.64 CD2 TLR2
31 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 ICAM1 IFNG TNF
32 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.62 IFNG IFNGR1
33 response to molecule of bacterial origin GO:0002237 9.62 IL10 TLR2
34 endothelial cell apoptotic process GO:0072577 9.6 IL10 TNF
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.57 IL10 TNF
36 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.56 ICAM1 TNF
37 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.55 MIF TNF
38 cytokine-mediated signaling pathway GO:0019221 9.5 ICAM1 IFNGR1 IL10 IL12RB1 IL12RB2 IL2
39 positive regulation of interferon-gamma production GO:0032729 9.46 IL12RB1 IL12RB2 IL2 TNF
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
41 positive regulation of cytokine secretion GO:0050715 9.43 IL10 MIF TNF
42 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
44 interleukin-12-mediated signaling pathway GO:0035722 9.02 IFNG IL10 IL12RB1 IL12RB2 MIF

Molecular functions related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.46 CD2 ICAM1 TLR2 VDR
2 cytokine binding GO:0019955 9.13 IFNGR1 IL12RB1 IL12RB2
3 cytokine activity GO:0005125 9.02 IFNG IL10 IL2 MIF TNF

Sources for Lepromatous Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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