MCID: LPR001
MIFTS: 52

Lepromatous Leprosy

Categories: Infectious diseases

Aliases & Classifications for Lepromatous Leprosy

MalaCards integrated aliases for Lepromatous Leprosy:

Name: Lepromatous Leprosy 12 15
Leprosy, Lepromatous 44 73
Leprosy Lepromatous 55
Type L Leprosy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10887
ICD10 33 A30.5
ICD9CM 35 030.0
MeSH 44 D015440
SNOMED-CT 68 21560005
UMLS 73 C0023348

Summaries for Lepromatous Leprosy

Disease Ontology : 12 A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

MalaCards based summary : Lepromatous Leprosy, also known as leprosy, lepromatous, is related to tuberculoid leprosy and sporotrichosis. An important gene associated with Lepromatous Leprosy is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clofazimine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 Lepromatous leprosy is a form of leprosy characterized by pale macules in the... more...

Related Diseases for Lepromatous Leprosy

Diseases related to Lepromatous Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 tuberculoid leprosy 31.0 IFNG IL10
2 sporotrichosis 31.0 IFNG IL10
3 oral tuberculosis 30.9 IL2 TNF
4 mucocutaneous leishmaniasis 30.7 IL10 TNF
5 tetanus 30.6 IFNG IL10 IL2
6 aspergillosis 30.4 IFNG IL10 TLR2
7 hemophagocytic lymphohistiocytosis 30.3 IFNG IL10 TNF
8 herpes zoster 30.2 IFNG IL10 IL2
9 cutaneous leishmaniasis 29.9 IFNG IL10 TLR2 TNF
10 myasthenia gravis 29.7 IFNG IL10 IL2 TNF
11 arthritis 29.4 IFNG IL10 MIF TNF
12 leprosy 3 29.4 IFNG IL10 IL12RB2 IL2 TLR2 TNF
13 leishmaniasis 29.4 IFNG IFNGR1 IL10 TLR2 TNF
14 systemic lupus erythematosus 29.1 ICAM1 IFNG IL10 IL2 TNF
15 pulmonary tuberculosis 27.4 IFNG IFNGR1 IL10 IL2 TLR2 TNF
16 rheumatoid arthritis 27.2 ICAM1 IFNG IL10 IL2 MIF TLR2
17 leprosy 1 11.5
18 punctate inner choroidopathy 10.8 IL10 TNF
19 trench fever 10.8 TLR2 TNF
20 staphylococcal toxic shock syndrome 10.8 IFNG TNF
21 tropical endomyocardial fibrosis 10.8 IL10 TNF
22 microscopic polyangiitis 10.7 IL10 TNF
23 multifocal choroiditis 10.7 IL10 TNF
24 tungiasis 10.7 IL10 TNF
25 endomyocardial fibrosis 10.7 IL10 TNF
26 trichosporonosis 10.7 IFNG TNF
27 hyperlucent lung 10.7 IFNG IL10
28 chronic beryllium disease 10.7 IFNG TNF
29 transient hypogammaglobulinemia 10.7 IL10 TNF
30 haemophilus influenzae 10.7 TLR2 TNF
31 neurosyphilis 10.7 IL10 TLR2
32 variola major 10.7 IFNG IL2
33 penicilliosis 10.7 TLR2 TNF
34 streptococcal toxic-shock syndrome 10.7 IL2 TNF
35 choroiditis 10.7 IL10 TNF
36 fixed drug eruption 10.7 IFNG IL2
37 idiopathic achalasia 10.7 IL10 TNF
38 nontuberculous mycobacterial lung disease 10.7 TLR2 TNF
39 berylliosis 10.7 IFNG IL2
40 trichuriasis 10.7 IL10 TNF
41 baylisascariasis 10.7 IFNG IL10
42 farmer's lung 10.6 IL2 TNF
43 myositis fibrosa 10.6 IFNG TLR2
44 mycobacterium abscessus 10.6 TLR2 TNF
45 chronic graft versus host disease 10.6 IFNG IL10
46 meconium aspiration syndrome 10.6 IFNG TNF
47 pericardial tuberculosis 10.6 IFNG IL10
48 atopic keratoconjunctivitis 10.6 IFNG IL2
49 soft tissue sarcoma 10.6 IFNG TNF
50 cytomegalovirus retinitis 10.5 IFNG TNF

Graphical network of the top 20 diseases related to Lepromatous Leprosy:



Diseases related to Lepromatous Leprosy

Symptoms & Phenotypes for Lepromatous Leprosy

GenomeRNAi Phenotypes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 CD2 ICAM1 IL10 IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 CD2 ICAM1 IL10 IL2 TNF

MGI Mouse Phenotypes related to Lepromatous Leprosy:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 IL10 IFNG IL12RB2 IFNGR1 ICAM1 VDR
2 cellular MP:0005384 10.15 IL10 IFNG IFNGR1 ICAM1 MIF VDR
3 digestive/alimentary MP:0005381 10.13 IFNG IL12RB2 IFNGR1 IL2 ICAM1 IL10
4 hematopoietic system MP:0005397 10.13 IFNG IL12RB2 IFNGR1 ICAM1 IL10 VDR
5 endocrine/exocrine gland MP:0005379 10.11 IFNG IL12RB2 IFNGR1 ICAM1 IL10 VDR
6 homeostasis/metabolism MP:0005376 10.1 IL10 IFNG IL12RB2 IFNGR1 ICAM1 MIF
7 immune system MP:0005387 10.07 IL10 IFNG IL12RB2 IFNGR1 ICAM1 VDR
8 integument MP:0010771 9.87 IL10 IFNG IFNGR1 ICAM1 VDR TLR2
9 liver/biliary system MP:0005370 9.8 IL10 IFNG IL12RB2 IFNGR1 TLR2 TNF
10 muscle MP:0005369 9.63 IL10 IFNG ICAM1 VDR TLR2 TNF
11 neoplasm MP:0002006 9.61 IFNG IL12RB2 IFNGR1 IL2 ICAM1 IL10
12 nervous system MP:0003631 9.23 ICAM1 IL10 IFNG IFNGR1 MIF VDR

Drugs & Therapeutics for Lepromatous Leprosy

Drugs for Lepromatous Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
2 Anti-Bacterial Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Vitamins Phase 4
6
Acetylcholine Approved Not Applicable 51-84-3 187
7
Nitric Oxide Approved Not Applicable 10102-43-9 145068 160954
8
Nitroprusside Approved, Investigational Not Applicable 15078-28-1 11963622
9 Antihypertensive Agents Not Applicable
10 Cholinergic Agents Not Applicable
11 Neurotransmitter Agents Not Applicable
12 Nitric Oxide Donors Not Applicable
13 Pharmaceutical Solutions Not Applicable
14 Vasodilator Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo
2 Microcirculatory Impairment in Patients With Leprosy Completed NCT02085317 Not Applicable acetylcholine Iontophoresis;sodium nitroprusside Iontophoresis
3 Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy No longer available NCT00852345 clofazamine

Search NIH Clinical Center for Lepromatous Leprosy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: leprosy, lepromatous

Genetic Tests for Lepromatous Leprosy

Anatomical Context for Lepromatous Leprosy

MalaCards organs/tissues related to Lepromatous Leprosy:

41
Skin, T Cells, Monocytes, Bone, Testes, Lymph Node, Myeloid

Publications for Lepromatous Leprosy

Articles related to Lepromatous Leprosy:

(show top 50) (show all 567)
# Title Authors Year
1
Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas. ( 29664381 )
2018
2
Erythema nodosum leprosum presenting as sweet's syndrome-like reaction in a borderline lepromatous leprosy patient. ( 29900900 )
2018
3
Serum Levels of Migration Inhibitory Factor (MIF) and <i>In Situ</i> Expression of MIF and Its Receptor CD74 in Lepromatous Leprosy Patients: A Preliminary Report. ( 29487601 )
2018
4
Systemic nocardiosis in a lepromatous leprosy patient with type 2 reaction. ( 29520868 )
2018
5
Mycobacterium lepromatosis Lepromatous Leprosy in US Citizen Who Traveled to Disease-Endemic Areas. ( 29048278 )
2017
6
Lepromatous leprosy-negative images giving the diagnostic clue. ( 29323094 )
2017
7
Lepromatous leprosy with Lucio's phenomenon. ( 28660648 )
2017
8
Th17 Response of Borderline-Lepromatous Leprosy Inhibits Rash Manifestation of Dapsone Hypersensitivity Syndrome: Case Report. ( 28937434 )
2017
9
The Armadillo Factor: Lepromatous Leprosy. ( 28623172 )
2017
10
Infiltration in a child's face due to borderline lepromatous leprosy. ( 29160527 )
2017
11
Cytological Diagnosis of Primary Cutaneous Aspergillosis Masquerading as Lipoma in a Known Case of Lepromatous Leprosy. ( 28658789 )
2017
12
Primary Cutaneous Histoplasmosis Masquerading as Lepromatous Leprosy. ( 28273974 )
2017
13
Structural and functional changes in the microcirculation of lepromatous leprosy patients - Observation using orthogonal polarization spectral imaging and laser Doppler flowmetry iontophoresis. ( 28419120 )
2017
14
Lepromatous leprosy in a renal transplant recipient. ( 28449328 )
2017
15
Two Cases of Lepromatous Leprosy from Exposure to Armadillos in Florida. ( 29139372 )
2017
16
Lepromatous leprosy simulating rheumatoid arthritis - Report of a neglected disease. ( 29186255 )
2017
17
Borderline lepromatous leprosy, Erythema Nodosum Leprosum and a generalized varicella zoster virus infection: a deadly combination. ( 28319279 )
2017
18
Leg ulcer in lepromatous leprosy - Case report. ( 27828650 )
2016
19
A Rare Case of Coexistence of Borderline Lepromatous Leprosy with Tuberculosis Verrucosa Cutis. ( 28003920 )
2016
20
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. ( 27891733 )
2016
21
Primary oral tuberculosis in a patient with lepromatous leprosy: Diagnostic dilemma. ( 26927999 )
2016
22
Association between STR -794 CATT5-8 and SNP -173 G/C polymorphisms in the MIF gene and Lepromatous Leprosy in Mestizo patients of western Mexico. ( 27426952 )
2016
23
Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients. ( 27764137 )
2016
24
Borderline Lepromatous Leprosy: A Case to Remember. ( 26888945 )
2016
25
Mycobacterium leprae-Infected Macrophages Preferentially Primed Regulatory T Cell Responses and Was Associated with Lepromatous Leprosy. ( 26751388 )
2016
26
Hertoghe sign: a hallmark of lepromatous leprosy. ( 27026695 )
2016
27
Crusted scabies in a patient with lepromatous leprosy. ( 27183357 )
2016
28
Activation and cytokine profile of monocyte derived dendritic cells in leprosy: in vitro stimulation by sonicated Mycobacterium leprae induces decreased level of IL-12p70 in lepromatous leprosy. ( 26222022 )
2015
29
A case of lepromatous leprosy with co-existing tuberculosis verrucosa cutis (TVC). ( 26502689 )
2015
30
A Lepromatous Leprosy Patient with Permanent Disability. ( 26537774 )
2015
31
Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy. ( 25970602 )
2015
32
Dapsone hypersensitivity syndrome in a lepromatous leprosy patient--A Case Report. ( 26502691 )
2015
33
Borderline Lepromatous Leprosy with Type 1 (Reversal) Reactions in a Chinese Man. ( 26251526 )
2015
34
A case of secondary syphilis with HIV, resembling borderline lepromatous leprosy. ( 26692613 )
2015
35
Disseminated cutaneous BCG infection following BCG immunotherapy in patients with lepromatous leprosy. ( 26502690 )
2015
36
Lymph node abscess and cardiac involvement in a patient with nodular lepromatous leprosy (LL) with erythema nodosum leprosum (ENL): a rare occurrence. ( 26065155 )
2015
37
Pulmonary Tuberculosis and Lepromatous Leprosy Coinfection. ( 26504603 )
2015
38
Diffuse Lepromatous Leprosy Due to Mycobacterium lepromatosis in Quintana Roo, Mexico. ( 26311856 )
2015
39
What is your diagnosis? lepromatous leprosy. ( 25671446 )
2015
40
Lepromatous leprosy: An Unusual Presentation. ( 26591848 )
2015
41
Persistent serpentine supravenous hyperpigmented eruption in lepromatous leprosy after minocycline. ( 26502692 )
2015
42
Laryngeal involvement causing dysphonia in a 29 year old nursing mother with lepromatous leprosy. ( 26327983 )
2015
43
Borderline Lepromatous Leprosy: Cutaneous Manifestation and Type 1 Reversal Reaction. ( 26439279 )
2015
44
Molluscum-like lesions in a 12-year-old boy: challenge. Lepromatous leprosy. ( 25415139 )
2014
45
Lepromatous leprosy mimicking systemic lupus erythematosus: a clinical pathology conference held by the division of rheumatology at hospital for special surgery. ( 25264448 )
2014
46
Oral manifestation of lepromatous leprosy: diagnosis and management. ( 24848267 )
2014
47
Fulminant hepatic failure in a 15 year old boy with borderline lepromatous leprosy and type 2 reaction. ( 24974443 )
2014
48
Case of lepromatous leprosy misdiagnosed as systemic sclerosis. ( 24480058 )
2014
49
Novel presentation of lepromatous leprosy in an erythema gyratum repens-like pattern. ( 24320626 )
2014
50
A case of lepromatous leprosy complicated by hemophagocytosis misdiagnosed as hemophagocytic lymphohistiocytosis. ( 24657272 )
2014

Variations for Lepromatous Leprosy

Expression for Lepromatous Leprosy

Search GEO for disease gene expression data for Lepromatous Leprosy.

Pathways for Lepromatous Leprosy

Pathways related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
2
Show member pathways
13.58 CD2 IFNG IFNGR1 IL10 IL12RB2 IL2
3
Show member pathways
13.42 CD2 IFNG IFNGR1 IL10 IL12RB2 IL2
4
Show member pathways
13.33 CD2 IL10 IL12RB2 IL2 TLR2 TNF
5
Show member pathways
13.28 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
6
Show member pathways
13.19 CD2 IL10 IL12RB2 IL2 TNF
7
Show member pathways
12.95 IFNG IFNGR1 IL10 IL2 TLR2 TNF
8
Show member pathways
12.79 ICAM1 IFNG IFNGR1 IL10 IL12RB2 IL2
9
Show member pathways
12.76 IFNG IFNGR1 IL2 TLR2 TNF
10 12.74 IFNG IFNGR1 IL12RB2 IL2
11
Show member pathways
12.74 ICAM1 IFNG IFNGR1 IL2 TLR2 TNF
12
Show member pathways
12.57 IFNG IFNGR1 IL10 IL12RB2 IL2 TNF
13
Show member pathways
12.53 IFNG IL10 IL2 TNF
14
Show member pathways
12.52 ICAM1 IFNGR1 TLR2 TNF
15 12.52 CD2 IFNG IL10 IL2 TLR2 TNF
16
Show member pathways
12.48 ICAM1 IFNG IFNGR1 IL2 TNF
17
Show member pathways
12.4 IFNG IL10 IL2 TNF
18
Show member pathways
12.31 ICAM1 IFNG IL2 TNF
19
Show member pathways
12.25 IFNG IFNGR1 MIF TNF
20
Show member pathways
12.24 IFNG IFNGR1 IL10 TLR2 TNF
21 12.21 ICAM1 IFNG IL10
22
Show member pathways
12.17 IFNG IFNGR1 TLR2 TNF
23 12.17 IFNG IFNGR1 TLR2 TNF
24
Show member pathways
12.13 IL10 IL2 TNF
25
Show member pathways
12.13 IFNG IFNGR1 TNF
26
Show member pathways
12.05 CD2 ICAM1 IFNG IFNGR1 IL10 IL2
27 12.05 IFNG IFNGR1 IL10 TLR2 TNF VDR
28 12.03 ICAM1 IFNG TNF
29 11.99 IFNG IFNGR1 TNF
30 11.94 ICAM1 IL10 TNF
31
Show member pathways
11.93 IFNG IL12RB2 IL2
32 11.93 ICAM1 IFNG IL2 MIF TNF
33
Show member pathways
11.92 IFNG IFNGR1 IL10 IL12RB2 IL2 TLR2
34 11.9 CD2 IFNG IL10 IL2 TNF
35 11.88 IFNG IL10 TLR2 TNF
36 11.88 IFNG IFNGR1 IL10 IL12RB2 IL2
37 11.85 ICAM1 IFNG TLR2 TNF
38 11.79 ICAM1 IFNG IL2
39
Show member pathways
11.75 IFNG IL2 TNF
40 11.75 IFNG IL10 IL2 TNF
41 11.67 IFNG IL10 IL12RB2 IL2 TNF
42
Show member pathways
11.65 IFNG IL2 TNF
43 11.56 IFNG IL2 TNF
44
Show member pathways
11.55 IFNG IFNGR1 TNF
45 11.54 ICAM1 IL10 TNF
46 11.52 IFNG IL2 TNF
47 11.52 IFNG TLR2 TNF
48 11.51 IFNG IL10 IL12RB2 IL2
49 11.49 IFNG TNF VDR
50
Show member pathways
11.45 ICAM1 IFNG IL2 MIF TNF

GO Terms for Lepromatous Leprosy

Cellular components related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ICAM1 IFNG IL10 IL2 MIF TNF
2 integral component of plasma membrane GO:0005887 9.63 CD2 ICAM1 IFNGR1 IL12RB2 TLR2 TNF
3 external side of plasma membrane GO:0009897 9.26 CD2 ICAM1 IL12RB2 TNF
4 cell surface GO:0009986 9.02 CD2 ICAM1 MIF TLR2 TNF

Biological processes related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 IL10 MIF TLR2 TNF
2 positive regulation of gene expression GO:0010628 9.93 IFNG TLR2 TNF VDR
3 immune response GO:0006955 9.93 IFNG IL10 IL2 TLR2 TNF
4 cell surface receptor signaling pathway GO:0007166 9.9 CD2 IFNG IL12RB2 MIF
5 regulation of signaling receptor activity GO:0010469 9.88 IFNG IL10 IL2 MIF TNF
6 leukocyte migration GO:0050900 9.85 CD2 ICAM1 MIF TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 ICAM1 TLR2 TNF
8 response to lipopolysaccharide GO:0032496 9.83 ICAM1 IL10 IL12RB2 TLR2
9 response to virus GO:0009615 9.79 IFNG IFNGR1 TNF
10 response to insulin GO:0032868 9.77 ICAM1 IL10 TLR2
11 interferon-gamma-mediated signaling pathway GO:0060333 9.76 ICAM1 IFNG IFNGR1
12 cell aging GO:0007569 9.69 ICAM1 MIF
13 protein import into nucleus, translocation GO:0000060 9.69 IFNG TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.69 CD2 MIF TLR2
15 positive regulation of interleukin-8 production GO:0032757 9.68 TLR2 TNF
16 negative regulation of interleukin-6 production GO:0032715 9.68 IL10 TNF
17 positive regulation of interleukin-12 production GO:0032735 9.68 IFNG TLR2
18 positive regulation of protein complex assembly GO:0031334 9.67 IFNG TNF
19 natural killer cell activation GO:0030101 9.67 CD2 IL2
20 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG TNF
21 positive regulation of interferon-gamma production GO:0032729 9.67 IL12RB2 IL2 TNF
22 positive regulation of protein phosphorylation GO:0001934 9.67 IFNG IL2 MIF TNF
23 positive regulation of chemokine production GO:0032722 9.66 TLR2 TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IFNG TNF
25 regulation of regulatory T cell differentiation GO:0045589 9.65 IFNG IL2
26 negative regulation of growth of symbiont in host GO:0044130 9.64 IL10 TNF
27 positive regulation of interleukin-8 secretion GO:2000484 9.64 CD2 TLR2
28 response to molecule of bacterial origin GO:0002237 9.63 IL10 TLR2
29 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.62 IFNG IFNGR1
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 TNF
31 endothelial cell apoptotic process GO:0072577 9.61 IL10 TNF
32 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
33 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 ICAM1 IFNG TNF
34 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.57 ICAM1 TNF
35 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.56 MIF TNF
36 cellular response to lipopolysaccharide GO:0071222 9.56 ICAM1 IL10 TNF VDR
37 receptor biosynthetic process GO:0032800 9.46 IL10 TNF
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG TNF
39 positive regulation of cytokine secretion GO:0050715 9.33 IL10 MIF TNF
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
41 interleukin-12-mediated signaling pathway GO:0035722 9.26 IFNG IL10 IL12RB2 MIF
42 cytokine-mediated signaling pathway GO:0019221 9.1 ICAM1 IFNGR1 IL10 IL12RB2 IL2 TNF
43 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 IL10 IL2 TLR2 TNF VDR

Molecular functions related to Lepromatous Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.9 CD2 ICAM1 IFNG IFNGR1 IL10 IL12RB2
2 signaling receptor activity GO:0038023 9.13 CD2 ICAM1 TLR2
3 cytokine activity GO:0005125 9.02 IFNG IL10 IL2 MIF TNF

Sources for Lepromatous Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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