LPRS1
MCID: LPR023
MIFTS: 24

Leprosy 1 (LPRS1)

Categories: Eye diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Leprosy 1

MalaCards integrated aliases for Leprosy 1:

Name: Leprosy 1 57
Leprosy, Paucibacillary Type, Susceptibility to 57 12
Leprosy, Susceptibility to, 1 57 5
Leprosy, Paucibacillary Type, Susceptibility to, 1 57
Leprosy, Paucibacillary Type 1 57
Hansen Disease, Paucibacillary 33
Leprosy, Paucibacillary Type 57
Leprosy, Paucibacillary 16
Lprs1 57

Classifications:



External Ids:

OMIM® 57 609888
ICD11 33 1800264981

Summaries for Leprosy 1

OMIM®: 57 Leprosy is a disease of peripheral sensory nerves that results from infection with Mycobacterium leprae, which was first detected in Bergen, Norway, in 1873 by Dr. Armauer Hansen. It can be effectively treated with long-term multidrug therapy. In 2006, more than 250,000 new cases of leprosy were reported to the World Health Organization. Many infected individuals have self-healing indeterminate lesions. Others with initially indeterminate lesions proceed to develop leprosy that can be classified along a clinical and immunologic spectrum from paucibacillary or tuberculoid leprosy to multibacillary or lepromatous leprosy. Most patients fall somewhere between these 2 polar forms of the disease and are classified, using pathology-based criteria developed by Ridley and Jopling (1966), as borderline tuberculoid, midborderline, and borderline lepromatous. The paucibacillary form is associated with strong M. leprae-specific cell-mediated immunity (CMI), whereas the multibacillary form is notable for the lack of antigen-specific CMI. The prevalence of paucibacillary versus multibacillary leprosy varies in different populations. M. leprae cannot be cultured in vitro and grows slowly in the footpads of mice, the liver and spleen of armadillos, and in some nonhuman primates. A genetic component to leprosy susceptibility has long been suspected. While contact with a multibacillary patient increases the relative risk of acquiring disease, most new patients have no known contact with other patients. For further information, see reviews by Fitness et al. (2002), Mira (2006), Moraes et al. (2006), Scollard et al. (2006), and Alter et al. (2008). (609888) (Updated 08-Dec-2022)

MalaCards based summary: Leprosy 1, also known as leprosy, paucibacillary type, susceptibility to, is related to leprosy 3 and lepromatous leprosy. An important gene associated with Leprosy 1 is LPRS (Leprosy, Susceptibility To 1). Affiliated tissues include spleen, liver and skin.

Related Diseases for Leprosy 1

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leprosy 3 29.7 TLR6 LPRS
2 lepromatous leprosy 9.8
3 indeterminate leprosy 9.8

Symptoms & Phenotypes for Leprosy 1

Clinical features from OMIM®:

609888 (Updated 08-Dec-2022)

Drugs & Therapeutics for Leprosy 1

Search Clinical Trials, NIH Clinical Center for Leprosy 1

Genetic Tests for Leprosy 1

Anatomical Context for Leprosy 1

Organs/tissues related to Leprosy 1:

MalaCards : Spleen, Liver, Skin

Publications for Leprosy 1

Articles related to Leprosy 1:

(show top 50) (show all 71)
# Title Authors PMID Year
1
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. 57
23449998 2013
2
Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases. 57
23103228 2012
3
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. 57
22019778 2011
4
Genomewide association study of leprosy. 57
20397291 2010
5
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. 57
19952355 2010
6
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. 57
20211140 2010
7
TB: screening for responses to a vile visitor. 57
20211131 2010
8
A common genetic fingerprint in leprosy and Crohn's disease? 57
20018963 2009
9
Genomewide association study of leprosy. 57
20018961 2009
10
Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy. 57
19430824 2009
11
Tryptophan aspartate-containing coat protein (CORO1A) suppresses Toll-like receptor signalling in Mycobacterium leprae infection. 57
19438603 2009
12
Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae. 57
19054096 2008
13
Leprosy as a genetic model for susceptibility to common infectious diseases. 57
18247059 2008
14
Genetics of host response in leprosy. 57
17171999 2006
15
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli. 57
16892039 2006
16
Genetic host resistance and susceptibility to leprosy. 57
16513393 2006
17
The continuing challenges of leprosy. 57
16614253 2006
18
On the origin of leprosy. 57
15894530 2005
19
Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians. 57
14735149 2004
20
Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. 57
14735151 2004
21
Use of genetic profiling in leprosy to discriminate clinical forms of the disease. 57
12970564 2003
22
Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. 57
12577057 2003
23
Genetics of susceptibility to leprosy. 57
12486602 2002
24
A major susceptibility locus for leprosy in India maps to chromosome 10p13. 57
11279529 2001
25
Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae. 57
11081637 2000
26
Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships. 57
10608779 2000
27
CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. 57
9973451 1999
28
Leprosy. 57
10030346 1999
29
Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. 57
9851927 1998
30
Susceptibility to leprosy is linked to the human NRAMP1 gene. 57
9419180 1998
31
Association of polymorphism at COL3A and CTLA4 loci on chromosome 2q31-33 with the clinical phenotype and in-vitro CMI status in healthy and leprosy subjects: a preliminary study. 57
9225967 1997
32
Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha2 chain. 57
9118224 1997
33
The genetic epidemiology of leprosy in a Brazilian population. 57
7726175 1995
34
Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island. 57
3341381 1988
35
Genetic epidemiology of the susceptibility to leprosy. 57
3549780 1987
36
HLA-linked genetic control of host response to Mycobacterium leprae. 57
63804 1976
37
Some remarks on the genetics of leprosy resistance. 57
5732545 1968
38
Classification of leprosy according to immunity. A five-group system. 57
5950347 1966
39
Nature and familial character of the lepromin reactions. 57
5863200 1965
40
Human macrophage polarization in the response to Mycobacterium leprae genomic DNA. 62
34841308 2021
41
Minimally invasive sampling to identify leprosy patients with a high bacterial burden in the Union of the Comoros. 62
34758041 2021
42
High-resolution ultrasound in the assessment of peripheral nerves in leprosy: A comparative cross-sectional study. 62
33769731 2021
43
Standardization of SYBR Green-Based Real-Time PCR Through the Evaluation of Different Thresholds for Different Skin Layers: An Accuracy Study and Track of the Transmission Potential of Multibacillary and Paucibacillary Leprosy Patients. 62
35035383 2021
44
Mobile Health Strategies to Tackle Skin Neglected Tropical Diseases With Recommendations From Innovative Experiences: Systematic Review. 62
33382382 2020
45
[The use of synthetic glycoconjugates as components of the immunochromatographic test for rapid serological diagnosis of leprosy.] 62
32298544 2020
46
Leprosy New Case Detection Trends and the Future Effect of Preventive Interventions in Pará State, Brazil: A Modelling Study. 62
26938738 2016
47
Role of s-100 immunostaining in demonstration of nerve changes and quantification of dendritic cells in leprosy. 62
24783075 2014
48
Factors associated with migration in individuals affected by leprosy, maranhão, Brazil: an exploratory cross-sectional study. 62
24194769 2013
49
Burden of leprosy in Malawi: community camp-based cross-sectional study. 62
22867526 2012
50
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. 62
22392826 2012

Variations for Leprosy 1

ClinVar genetic disease variations for Leprosy 1:

5 (show all 20)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TLR1 NM_003263.4(TLR1):c.1805G>T (p.Ser602Ile) SNV Uncertain Risk Allele
8360 rs5743618 GRCh37: 4:38798648-38798648
GRCh38: 4:38797027-38797027
2 MRC1 NM_002438.4(MRC1):c.1186G>A (p.Gly396Ser) SNV Uncertain Risk Allele
64687 rs606231248 GRCh37: 10:18138630-18138630
GRCh38: 10:17849701-17849701
3 LRRK2 NM_198578.4(LRRK2):c.7190T>C (p.Met2397Thr) SNV Confers Sensitivity
308647 rs3761863 GRCh37: 12:40758652-40758652
GRCh38: 12:40364850-40364850
4 IL10, IL19 NM_153758.5(IL19):c.-149+2211A>G SNV Uncertain Risk Allele
1166836 GRCh37: 1:206946634-206946634
GRCh38: 1:206773289-206773289
5 CCDC122, LACC1 NM_153218.4(LACC1):c.760A>G (p.Ile254Val) SNV Uncertain Risk Allele
1300105 GRCh37: 13:44457925-44457925
GRCh38: 13:43883789-43883789
6 TNFSF15 NM_005118.4(TNFSF15):c.211-2855G>C SNV Confers Sensitivity
1710525 GRCh37: 9:117558703-117558703
GRCh38: 9:114796423-114796423
7 TNFSF15 NM_005118.4(TNFSF15):c.*4960A>G SNV Uncertain Risk Allele
1710526 GRCh37: 9:117547772-117547772
GRCh38: 9:114785492-114785492
8 LRRK2 NM_198578.4(LRRK2):c.4739-122T>A SNV Uncertain Risk Allele
1710527 GRCh37: 12:40708892-40708892
GRCh38: 12:40315090-40315090
9 CCDC122 NM_144974.5(CCDC122):c.555+178G>T SNV Uncertain Risk Allele
1710528 GRCh37: 13:44433630-44433630
GRCh38: 13:43859494-43859494
10 LACC1 NC_000013.11:g.43904864A>G SNV Uncertain Risk Allele
1710529 GRCh37: 13:44479000-44479000
GRCh38: 13:43904864-43904864
11 NOD2 NM_001370466.1(NOD2):c.459+168G>A SNV Uncertain Risk Allele
1710530 GRCh37: 16:50734033-50734033
GRCh38: 16:50700122-50700122
12 IL10, IL19 NM_153758.5(IL19):c.-149+2474T>C SNV Uncertain Risk Allele
1710531 GRCh37: 1:206946897-206946897
GRCh38: 1:206773552-206773552
13 NOD2 NM_001370466.1(NOD2):c.460-3786A>G SNV Confers Sensitivity
1710532 GRCh37: 16:50737980-50737980
GRCh38: 16:50704069-50704069
14 PINK1, PINK1-AS NR_046507.1(PINK1-AS):n.629C>T SNV Uncertain Risk Allele
1710533 GRCh37: 1:20978058-20978058
GRCh38: 1:20651565-20651565
15 PARL NM_018622.7(PARL):c.511+4771C>T SNV Uncertain Risk Allele
1710534 GRCh37: 3:183575770-183575770
GRCh38: 3:183857982-183857982
16 TLR6 NM_006068.5(TLR6):c.745T>G (p.Ser249Ala) SNV Protective
1710535 GRCh37: 4:38830350-38830350
GRCh38: 4:38828729-38828729
17 RIPK2 NC_000008.11:g.89811459A>G SNV Uncertain Risk Allele
1710536 GRCh37: 8:90823687-90823687
GRCh38: 8:89811459-89811459
18 RIPK2 NM_003821.6(RIPK2):c.483+789G>A SNV Uncertain Risk Allele
1710537 GRCh37: 8:90778513-90778513
GRCh38: 8:89766285-89766285
19 TNFSF15 NC_000009.12:g.114776054C>T SNV Uncertain Risk Allele
1710538 GRCh37: 9:117538334-117538334
GRCh38: 9:114776054-114776054
20 NOD2 NM_001370466.1(NOD2):c.*397A>C SNV Uncertain Risk Allele
319482 rs3135499 GRCh37: 16:50766127-50766127
GRCh38: 16:50732216-50732216

Expression for Leprosy 1

Search GEO for disease gene expression data for Leprosy 1.

Pathways for Leprosy 1

GO Terms for Leprosy 1

Sources for Leprosy 1

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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