MCID: LPR023
MIFTS: 18

Leprosy 1

Categories: Genetic diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Leprosy 1

MalaCards integrated aliases for Leprosy 1:

Name: Leprosy 1 57
Leprosy, Paucibacillary Type, Susceptibility to 57 13
Leprosy, Paucibacillary Type, Susceptibility to, 1 57
Leprosy, Paucibacillary Type 1 57
Leprosy, Susceptibility to, 1 57
Leprosy, Paucibacillary Type 57
Lprs1 57

Classifications:



External Ids:

OMIM 57 609888

Summaries for Leprosy 1

OMIM : 57 Leprosy is a disease of peripheral sensory nerves that results from infection with Mycobacterium leprae, which was first detected in Bergen, Norway, in 1873 by Dr. Armauer Hansen. It can be effectively treated with long-term multidrug therapy. In 2006, more than 250,000 new cases of leprosy were reported to the World Health Organization. Many infected individuals have self-healing indeterminate lesions. Others with initially indeterminate lesions proceed to develop leprosy that can be classified along a clinical and immunologic spectrum from paucibacillary or tuberculoid leprosy to multibacillary or lepromatous leprosy. Most patients fall somewhere between these 2 polar forms of the disease and are classified, using pathology-based criteria developed by Ridley and Jopling (1966), as borderline tuberculoid, midborderline, and borderline lepromatous. The paucibacillary form is associated with strong M. leprae-specific cell-mediated immunity (CMI), whereas the multibacillary form is notable for the lack of antigen-specific CMI. The prevalence of paucibacillary versus multibacillary leprosy varies in different populations. M. leprae cannot be cultured in vitro and grows slowly in the footpads of mice, the liver and spleen of armadillos, and in some nonhuman primates. A genetic component to leprosy susceptibility has long been suspected. While contact with a multibacillary patient increases the relative risk of acquiring disease, most new patients have no known contact with other patients. For further information, see reviews by Fitness et al. (2002), Mira (2006), Moraes et al. (2006), Scollard et al. (2006), and Alter et al. (2008). (609888)

MalaCards based summary : Leprosy 1, also known as leprosy, paucibacillary type, susceptibility to, is related to lepromatous leprosy and indeterminate leprosy. An important gene associated with Leprosy 1 is LPRS (Leprosy, Susceptibility To 1). Affiliated tissues include liver and spleen.

Related Diseases for Leprosy 1

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 lepromatous leprosy 9.6
2 indeterminate leprosy 9.6

Symptoms & Phenotypes for Leprosy 1

Clinical features from OMIM:

609888

Drugs & Therapeutics for Leprosy 1

Search Clinical Trials , NIH Clinical Center for Leprosy 1

Genetic Tests for Leprosy 1

Anatomical Context for Leprosy 1

MalaCards organs/tissues related to Leprosy 1:

41
Liver, Spleen

Publications for Leprosy 1

Articles related to Leprosy 1:

# Title Authors Year
1
Ulnar nerve abscess and relapse in a patient with indeterminate leprosy 1 year after completion of multidrug therapy. ( 15995337 )
2005
2
Denatured muscle grafts for nerve repair in an experimental model of nerve damage in leprosy. 1. A functional and morphometric study. ( 8189090 )
1994
3
A study of drug interactions in leprosy--1. Effect of simultaneous administration of prothionamide on metabolic disposition of rifampicin and dapsone. ( 3702578 )
1986
4
Immunity to leprosy. 1. The proliferative response of murine T lymphocytes to Mycobacterium leprae. ( 3900249 )
1985
5
Acid mucopolysaccharide metabolism in leprosy. 1. Storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy. ( 4142476 )
1974
6
Nerves in the arm in leprosy. 1. Clinical, electrodiagnostic and operative aspects. ( 4320831 )
1970
7
Leprosy. 1. ( 5434375 )
1970
8
CHEMOTHERAPEUTIC TRIALS IN LEPROSY. 1. COMPARATIVE TRIAL OF MACROCYCLON PLUS DAPSONE AND DAPSONE ALONE IN THE TREATMENT OF LEPROMATOUS LEPROSY. ( 14071942 )
1963
9
Serum protein patterns in leprosy. 1. Carville survey. ( 13773585 )
1960
10
Classification of leprosy. 1. Application of the Madrid classification of various forms of leprosy. ( 13720259 )
1960

Variations for Leprosy 1

Expression for Leprosy 1

Search GEO for disease gene expression data for Leprosy 1.

Pathways for Leprosy 1

GO Terms for Leprosy 1

Sources for Leprosy 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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