LPRS1
MCID: LPR023
MIFTS: 19

Leprosy 1 (LPRS1)

Categories: Endocrine diseases, Eye diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Leprosy 1

MalaCards integrated aliases for Leprosy 1:

Name: Leprosy 1 57
Leprosy, Paucibacillary Type, Susceptibility to 57 13
Leprosy, Paucibacillary Type, Susceptibility to, 1 57
Leprosy, Paucibacillary Type 1 57
Leprosy, Susceptibility to, 1 57
Leprosy, Paucibacillary Type 57
Leprosy, Paucibacillary 17
Lprs1 57

Classifications:



External Ids:

OMIM® 57 609888

Summaries for Leprosy 1

OMIM® : 57 Leprosy is a disease of peripheral sensory nerves that results from infection with Mycobacterium leprae, which was first detected in Bergen, Norway, in 1873 by Dr. Armauer Hansen. It can be effectively treated with long-term multidrug therapy. In 2006, more than 250,000 new cases of leprosy were reported to the World Health Organization. Many infected individuals have self-healing indeterminate lesions. Others with initially indeterminate lesions proceed to develop leprosy that can be classified along a clinical and immunologic spectrum from paucibacillary or tuberculoid leprosy to multibacillary or lepromatous leprosy. Most patients fall somewhere between these 2 polar forms of the disease and are classified, using pathology-based criteria developed by Ridley and Jopling (1966), as borderline tuberculoid, midborderline, and borderline lepromatous. The paucibacillary form is associated with strong M. leprae-specific cell-mediated immunity (CMI), whereas the multibacillary form is notable for the lack of antigen-specific CMI. The prevalence of paucibacillary versus multibacillary leprosy varies in different populations. M. leprae cannot be cultured in vitro and grows slowly in the footpads of mice, the liver and spleen of armadillos, and in some nonhuman primates. A genetic component to leprosy susceptibility has long been suspected. While contact with a multibacillary patient increases the relative risk of acquiring disease, most new patients have no known contact with other patients. For further information, see reviews by Fitness et al. (2002), Mira (2006), Moraes et al. (2006), Scollard et al. (2006), and Alter et al. (2008). (609888) (Updated 05-Apr-2021)

MalaCards based summary : Leprosy 1, also known as leprosy, paucibacillary type, susceptibility to, is related to leprosy 3 and hansen's disease. An important gene associated with Leprosy 1 is LPRS (Leprosy, Susceptibility To 1). Affiliated tissues include spleen and skin.

Related Diseases for Leprosy 1

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leprosy 3 10.3
2 hansen's disease 10.3
3 lepromatous leprosy 9.8
4 indeterminate leprosy 9.8

Symptoms & Phenotypes for Leprosy 1

Clinical features from OMIM®:

609888 (Updated 05-Apr-2021)

Drugs & Therapeutics for Leprosy 1

Search Clinical Trials , NIH Clinical Center for Leprosy 1

Genetic Tests for Leprosy 1

Anatomical Context for Leprosy 1

MalaCards organs/tissues related to Leprosy 1:

40
Spleen, Skin

Publications for Leprosy 1

Articles related to Leprosy 1:

(show top 50) (show all 64)
# Title Authors PMID Year
1
Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. 57
23449998 2013
2
Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases. 57
23103228 2012
3
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. 57
22019778 2011
4
Genomewide association study of leprosy. 57
20397291 2010
5
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. 57
19952355 2010
6
The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. 57
20211140 2010
7
TB: screening for responses to a vile visitor. 57
20211131 2010
8
Genomewide association study of leprosy. 57
20018961 2009
9
A common genetic fingerprint in leprosy and Crohn's disease? 57
20018963 2009
10
Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy. 57
19430824 2009
11
Tryptophan aspartate-containing coat protein (CORO1A) suppresses Toll-like receptor signalling in Mycobacterium leprae infection. 57
19438603 2009
12
Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae. 57
19054096 2008
13
Leprosy as a genetic model for susceptibility to common infectious diseases. 57
18247059 2008
14
Genetics of host response in leprosy. 57
17171999 2006
15
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli. 57
16892039 2006
16
The continuing challenges of leprosy. 57
16614253 2006
17
Genetic host resistance and susceptibility to leprosy. 57
16513393 2006
18
On the origin of leprosy. 57
15894530 2005
19
Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. 57
14735151 2004
20
Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians. 57
14735149 2004
21
Use of genetic profiling in leprosy to discriminate clinical forms of the disease. 57
12970564 2003
22
Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. 57
12577057 2003
23
Genetics of susceptibility to leprosy. 57
12486602 2002
24
A major susceptibility locus for leprosy in India maps to chromosome 10p13. 57
11279529 2001
25
Role of the cell wall phenolic glycolipid-1 in the peripheral nerve predilection of Mycobacterium leprae. 57
11081637 2000
26
Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships. 57
10608779 2000
27
Leprosy. 57
10030346 1999
28
CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity. 57
9973451 1999
29
Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. 57
9851927 1998
30
Susceptibility to leprosy is linked to the human NRAMP1 gene. 57
9419180 1998
31
Association of polymorphism at COL3A and CTLA4 loci on chromosome 2q31-33 with the clinical phenotype and in-vitro CMI status in healthy and leprosy subjects: a preliminary study. 57
9225967 1997
32
Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha2 chain. 57
9118224 1997
33
The genetic epidemiology of leprosy in a Brazilian population. 57
7726175 1995
34
Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island. 57
3341381 1988
35
Genetic epidemiology of the susceptibility to leprosy. 57
3549780 1987
36
HLA-linked genetic control of host response to Mycobacterium leprae. 57
63804 1976
37
Some remarks on the genetics of leprosy resistance. 57
5732545 1968
38
Classification of leprosy according to immunity. A five-group system. 57
5950347 1966
39
Nature and familial character of the lepromin reactions. 57
5863200 1965
40
High-resolution ultrasound in the assessment of peripheral nerves in leprosy: A comparative cross-sectional study. 61
33769731 2021
41
Mobile Health Strategies to Tackle Skin Neglected Tropical Diseases With Recommendations From Innovative Experiences: Systematic Review. 61
33382382 2020
42
Leprosy New Case Detection Trends and the Future Effect of Preventive Interventions in Pará State, Brazil: A Modelling Study. 61
26938738 2016
43
Role of s-100 immunostaining in demonstration of nerve changes and quantification of dendritic cells in leprosy. 61
24783075 2014
44
Factors associated with migration in individuals affected by leprosy, maranhão, Brazil: an exploratory cross-sectional study. 61
24194769 2013
45
Burden of leprosy in Malawi: community camp-based cross-sectional study. 61
22867526 2012
46
Leprosy. 61
21418690 2010
47
Leprosy. 61
19454067 2007
48
Ulnar nerve abscess and relapse in a patient with indeterminate leprosy 1 year after completion of multidrug therapy. 61
15995337 2005
49
Skin and treponemal diseases among Asian domestic house-helpers in northern Saudi Arabia. 61
9352403 1997
50
[Continent urinary diversion in neurogenic bladders]. 61
8767811 1996

Variations for Leprosy 1

Expression for Leprosy 1

Search GEO for disease gene expression data for Leprosy 1.

Pathways for Leprosy 1

GO Terms for Leprosy 1

Sources for Leprosy 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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