LPRS2
MCID: LPR022
MIFTS: 34

Leprosy 2 (LPRS2)

Categories: Endocrine diseases, Eye diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Leprosy 2

MalaCards integrated aliases for Leprosy 2:

Name: Leprosy 2 57 29
Leprosy, Susceptibility to, 2 57 73
Leprosy 57 73
Leprosy, Susceptibility to 57
Leprosy, Type 2 40
Lprs2 57

Classifications:



External Ids:

OMIM 57 607572

Summaries for Leprosy 2

MalaCards based summary : Leprosy 2, also known as leprosy, susceptibility to, 2, is related to rhinitis and complex regional pain syndrome. An important gene associated with Leprosy 2 is PRKN (Parkin RBR E3 Ubiquitin Protein Ligase), and among its related pathways/superpathways are Neuroscience and G alpha (s) signalling events. Affiliated tissues include skin, eye and kidney.

Description from OMIM: 607572

Related Diseases for Leprosy 2

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
# Related Disease Score Top Affiliating Genes
1 rhinitis 29.4 NPY VIP
2 complex regional pain syndrome 29.4 CALCA NPY
3 tuberculoid leprosy 12.6
4 borderline leprosy 12.6
5 indeterminate leprosy 12.5
6 hansen's disease 12.1
7 leprosy 3 11.5
8 leprosy 4 11.3
9 peripheral nervous system disease 11.3
10 sensory peripheral neuropathy 11.3
11 mononeuritis multiplex 11.3
12 buruli ulcer 11.3
13 mononeuropathy 11.3
14 chronic rhinitis 11.3
15 fetal thalidomide syndrome 11.3
16 trigeminal trophic syndrome 11.3
17 leprosy 1 11.2
18 leprosy 5 11.2
19 leprosy 6 11.2
20 macs syndrome 11.0
21 autoimmune peripheral neuropathy 11.0
22 mycobacterium kansasii 11.0
23 neuropathy 10.4
24 leishmaniasis 10.3
25 lagophthalmos 10.3
26 foot drop 10.2
27 neuritis 10.2
28 australia antigen 10.2
29 hepatitis 10.1
30 amyloidosis 10.1
31 arthritis 10.1
32 cutaneous leishmaniasis 10.1
33 syphilis 10.1
34 malaria 10.0
35 glomerulonephritis 10.0
36 myiasis 10.0
37 tetanus 10.0
38 pulmonary tuberculosis 10.0
39 lupus erythematosus 10.0
40 molluscum contagiosum 10.0
41 systemic lupus erythematosus 10.0
42 lymphoma 10.0
43 psoriasis 10.0
44 wdha syndrome 10.0 CALCA VIP
45 vasomotor rhinitis 10.0 CALCA VIP
46 cluster headache 10.0 CALCA VIP
47 thrombosis 10.0
48 elephantiasis 10.0
49 dysautonomia 10.0
50 pancreatic cholera 10.0 CALCA VIP

Graphical network of the top 20 diseases related to Leprosy 2:



Diseases related to Leprosy 2

Symptoms & Phenotypes for Leprosy 2

Clinical features from OMIM:

607572

Drugs & Therapeutics for Leprosy 2

Search Clinical Trials , NIH Clinical Center for Leprosy 2

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Leprosy 2

Genetic tests related to Leprosy 2:

# Genetic test Affiliating Genes
1 Leprosy 2 29 PRKN

Anatomical Context for Leprosy 2

MalaCards organs/tissues related to Leprosy 2:

41
Skin, Eye, Kidney, Liver, Heart, T Cells, Cortex

Publications for Leprosy 2

Articles related to Leprosy 2:

# Title Authors Year
1
Denatured muscle grafts for nerve repair in an experimental model of nerve damage in leprosy. 2. Recovery of peripheral peptide-containing nerves assessed by quantitative immunohistochemical study. ( 7514642 )
1994
2
Chemotherapeutic trials in leprosy. 2. Comparative trial of dapsone plus ditophal (Etisul) and dapsone alone in the treatment of lepromatous leprosy. ( 5322767 )
1965

Variations for Leprosy 2

Expression for Leprosy 2

Search GEO for disease gene expression data for Leprosy 2.

Pathways for Leprosy 2

Pathways related to Leprosy 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 CALCA NPY PRKN VIP
2 11.32 CALCA VIP
3 10.49 CALCA NPY

GO Terms for Leprosy 2

Cellular components related to Leprosy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 8.8 CALCA PRKN VIP

Biological processes related to Leprosy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.61 CALCA NPY VIP
2 cellular protein metabolic process GO:0044267 9.46 CALCA PRKN
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.4 CALCA VIP
4 neuropeptide signaling pathway GO:0007218 9.37 CALCA NPY
5 regulation of signaling receptor activity GO:0010469 9.33 CALCA NPY VIP
6 positive regulation of protein catabolic process GO:0045732 9.32 PRKN VIP
7 regulation of blood pressure GO:0008217 9.26 CALCA NPY
8 feeding behavior GO:0007631 8.96 CALCA NPY
9 positive regulation of blood vessel diameter GO:0097755 8.62 CALCA VIP

Molecular functions related to Leprosy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.16 NPY PRKN
2 neuropeptide hormone activity GO:0005184 8.96 NPY VIP
3 hormone activity GO:0005179 8.8 CALCA NPY VIP

Sources for Leprosy 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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