MCID: LPR022
MIFTS: 25

Leprosy 2

Categories: Genetic diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Rare diseases

Aliases & Classifications for Leprosy 2

MalaCards integrated aliases for Leprosy 2:

Name: Leprosy 2 57 29
Leprosy, Susceptibility to, 2 57 73
Leprosy 57 73
Leprosy, Susceptibility to 57
Leprosy, Type 2 40
Lprs2 57

Classifications:



External Ids:

OMIM 57 607572
UMLS 73 C1843632

Summaries for Leprosy 2

MalaCards based summary : Leprosy 2, also known as leprosy, susceptibility to, 2, is related to leprosy 3 and leprosy 4. An important gene associated with Leprosy 2 is PRKN (Parkin RBR E3 Ubiquitin Protein Ligase), and among its related pathways/superpathways are Neuroscience and G alpha (s) signalling events.

Description from OMIM: 607572

Related Diseases for Leprosy 2

Graphical network of the top 20 diseases related to Leprosy 2:



Diseases related to Leprosy 2

Symptoms & Phenotypes for Leprosy 2

Clinical features from OMIM:

607572

Drugs & Therapeutics for Leprosy 2

Search Clinical Trials , NIH Clinical Center for Leprosy 2

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Leprosy 2

Genetic tests related to Leprosy 2:

# Genetic test Affiliating Genes
1 Leprosy 2 29 PRKN

Anatomical Context for Leprosy 2

Publications for Leprosy 2

Articles related to Leprosy 2:

# Title Authors Year
1
Denatured muscle grafts for nerve repair in an experimental model of nerve damage in leprosy. 2. Recovery of peripheral peptide-containing nerves assessed by quantitative immunohistochemical study. ( 7514642 )
1994

Variations for Leprosy 2

Expression for Leprosy 2

Search GEO for disease gene expression data for Leprosy 2.

Pathways for Leprosy 2

Pathways related to Leprosy 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 CALCA NPY PRKN VIP
2 11.32 CALCA VIP
3 10.49 CALCA NPY

GO Terms for Leprosy 2

Biological processes related to Leprosy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.58 CALCA NPY VIP
2 cellular protein metabolic process GO:0044267 9.43 CALCA PRKN
3 neuropeptide signaling pathway GO:0007218 9.37 CALCA NPY
4 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.32 CALCA VIP
5 positive regulation of protein catabolic process GO:0045732 9.26 PRKN VIP
6 regulation of blood pressure GO:0008217 9.16 CALCA NPY
7 regulation of signaling receptor activity GO:0010469 9.13 CALCA NPY VIP
8 feeding behavior GO:0007631 8.62 CALCA NPY

Molecular functions related to Leprosy 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor binding GO:0001664 9.16 NPY PRKN
2 neuropeptide hormone activity GO:0005184 8.96 NPY VIP
3 hormone activity GO:0005179 8.8 CALCA NPY VIP

Sources for Leprosy 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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