LPRS3
MCID: LPR021
MIFTS: 70

Leprosy 3 (LPRS3)

Categories: Endocrine diseases, Eye diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Leprosy 3

MalaCards integrated aliases for Leprosy 3:

Name: Leprosy 3 57 29 6
Leprosy 57 12 76 25 59 3 44 15 73
Leprosy, Susceptibility to 57 13
Infection Due to Mycobacterium Leprae 25
Leprosy, Susceptibility to, 3 57
Hansen's Disease 25
Leprosy, Type 3 40
Hansen Disease 25
Lprs3 57

Characteristics:

Orphanet epidemiological data:

59
leprosy
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000 (Worldwide); Age of onset: All ages; Age of death: any age;

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
see for a discussion on leprosy susceptibility



Classifications:



External Ids:

OMIM 57 246300
Disease Ontology 12 DOID:1024
ICD10 33 A30 A30.9
ICD9CM 35 030 030.9
MeSH 44 D007918
NCIt 50 C84824
SNOMED-CT 68 81004002
Orphanet 59 ORPHA548
UMLS via Orphanet 74 C0023343
MESH via Orphanet 45 D007918
MedGen 42 C1968668
SNOMED-CT via HPO 69 263681008 258211005
UMLS 73 C0023343

Summaries for Leprosy 3

Genetics Home Reference : 25 Leprosy, also called Hansen disease, is a disorder known since ancient times. It is caused by bacteria called Mycobacterium leprae and is contagious, which means that it can be passed from person to person. It is usually contracted by breathing airborne droplets from affected individuals' coughs and sneezes, or by coming into contact with their nasal fluids. However, it is not highly transmissible, and approximately 95 percent of individuals who are exposed to Mycobacterium leprae never develop leprosy. The infection can be contracted at any age, and signs and symptoms can take anywhere from several months to 20 years to appear.

MalaCards based summary : Leprosy 3, also known as leprosy, is related to borderline leprosy and tuberculoid leprosy, and has symptoms including sensory loss, skin lesions and motor loss. An important gene associated with Leprosy 3 is TLR2 (Toll Like Receptor 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. Affiliated tissues include skin, eye and testes, and related phenotypes are abnormality of the immune system and cellular

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in superficial peripheral nerves, located in skin, located in mucous membranes of the upper respiratory tract, located in anterior chamber of the eyes, or located in testes, has material basis in Mycobacterium leprae, which is transmitted by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has symptom skin lesions, has symptom sensory loss, has symptom motor loss and has symptom eye damage.

Wikipedia : 76 Leprosy, also known as Hansen''s disease (HD), is a long-term infection by the bacterium Mycobacterium... more...

Description from OMIM: 246300

Related Diseases for Leprosy 3

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 493)
# Related Disease Score Top Affiliating Genes
1 borderline leprosy 34.5 MLLT1 SDHD
2 tuberculoid leprosy 34.3 IFNG IL10 MLLT1 SDHD
3 peripheral nervous system disease 32.5 MLLT1 SDHD TNF
4 buruli ulcer 32.2 IFNG IL10 IL4 SLC11A1
5 neuritis 30.6 IFNG IL4 TNF
6 leishmaniasis 30.5 IFNG IL10 IL2 IL4 SLC11A1 TLR2
7 arthritis 30.3 IFNG IL10 LACC1 NOD2 TNF
8 tetanus 30.3 IFNG IL10 IL2 IL4
9 erythema multiforme 30.2 IFNG IL2 TNF
10 cutaneous leishmaniasis 30.2 IFNG IL10 IL4 SLC11A1 TLR2 TNF
11 multidrug-resistant tuberculosis 30.1 IL10 SLC11A1 TNF
12 sporotrichosis 30.1 IFNG IL10
13 systemic lupus erythematosus 30.1 IFNG IL10 IL2 IL4 TLR2 TNF
14 filarial elephantiasis 30.1 IL10 IL4 TLR2
15 malaria 30.1 IFNG IL10 IL2 IL4 TLR2 TNF
16 filariasis 30.1 IFNG IL10 IL2 TLR2 TNF
17 psoriasis 30.1 IFNG IL10 IL2 IL4 TNF
18 pulmonary tuberculosis 30.1 IFNG IL10 IL2 IL4 SLC11A1 TLR2
19 human immunodeficiency virus infectious disease 30.0 IFNG IL10 IL2 TNF
20 rheumatic disease 30.0 IFNG IL10 TNF
21 melioidosis 29.9 IFNG IL10 TLR2 TNF
22 lymphadenitis 29.9 IFNG IL10 NOD2 SLC11A1 TNF
23 granulomatous dermatitis 29.9 NOD2 TNF
24 viral infectious disease 29.9 IFNG IL10 IL2 IL4 TNF
25 poliomyelitis 29.9 IFNG IL10 IL4 TNF
26 oral tuberculosis 29.9 IL2 TNF
27 chagas disease 29.9 IFNG IL10 IL2 TLR2 TNF
28 contact dermatitis 29.9 IFNG IL10 IL4 TNF
29 periodontal disease 29.9 HSPD1 TLR2 TNF
30 demyelinating disease 29.8 IFNG IL10 TNF
31 crohn's disease 29.8 IL10 IL12RB2 LACC1 NOD2 SLC11A1 TNF
32 sarcoidosis 1 29.8 IFNG IL2 NOD2 SLC11A1 TNF
33 aspergillosis 29.8 IFNG IL10 IL4 TLR2 TNF
34 rheumatic fever 29.8 IL10 IL2 TNF
35 visceral leishmaniasis 29.8 IFNG IL10 IL2 IL4 SLC11A1 TLR2
36 rheumatoid arthritis 29.7 IFNG IL10 IL2 IL4 LACC1 SLC11A1
37 uveitis 29.7 IFNG IL10 IL4 NOD2 TNF
38 scleritis 29.7 IFNG IL4 TNF
39 lyme disease 29.7 HSPD1 TLR2 TNF
40 herpes zoster 29.7 IFNG IL10 IL2
41 lepromatous leprosy 29.7 IFNG IL10 IL12RB2 IL2 TLR2 TNF
42 meningitis 29.7 IFNG IL10 TLR2 TNF
43 keratoconjunctivitis sicca 29.7 IL10 IL4 TNF
44 acquired immunodeficiency syndrome 29.7 IFNG IL10 IL2 TNF
45 connective tissue disease 29.7 HSPD1 IFNG IL10 TNF
46 smallpox 29.6 IFNG IL12RB2 IL2 TNF
47 osteomyelitis 29.6 IFNG IL10 TNF
48 keratoconjunctivitis 29.6 IFNG IL2 IL4 TNF
49 allergic contact dermatitis 29.6 IFNG IL10 IL4 TNF
50 schistosomiasis 29.5 IFNG IL10 IL2 IL4 TNF

Comorbidity relations with Leprosy 3 via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Leprosy 3:



Diseases related to Leprosy 3

Symptoms & Phenotypes for Leprosy 3

Symptoms via clinical synopsis from OMIM:

57
Immunology:
susceptibility to infection by mycobacterium leprae causing leprosy


Clinical features from OMIM:

246300

Symptoms:

12
  • sensory loss
  • skin lesions
  • motor loss
  • eye damage

Human phenotypes related to Leprosy 3:

32
# Description HPO Frequency HPO Source Accession
1 abnormality of the immune system 32 HP:0002715

MGI Mouse Phenotypes related to Leprosy 3:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 HSPD1 IFNG IL10 IL2 IL4 LACC1
2 hematopoietic system MP:0005397 10.25 IFNG IL10 IL12RB2 IL2 IL4 LACC1
3 homeostasis/metabolism MP:0005376 10.18 IFNG IL10 IL12RB2 IL2 IL4 LACC1
4 immune system MP:0005387 10.15 IFNG IL10 IL12RB2 IL2 IL4 LACC1
5 digestive/alimentary MP:0005381 10.13 IFNG IL10 IL12RB2 IL2 IL4 NOD2
6 endocrine/exocrine gland MP:0005379 10.11 IFNG IL10 IL12RB2 IL2 IL4 LRRK2
7 mortality/aging MP:0010768 10.07 HSPD1 IFNG IL10 IL2 IL4 LRRK2
8 liver/biliary system MP:0005370 9.92 IFNG IL10 IL12RB2 IL2 IL4 MLLT1
9 neoplasm MP:0002006 9.81 IFNG IL10 IL12RB2 IL2 MLLT1 SDHD
10 no phenotypic analysis MP:0003012 9.5 IFNG IL10 IL2 IL4 LRRK2 PRKN
11 respiratory system MP:0005388 9.23 IFNG IL10 IL2 IL4 LRRK2 PRKN

Drugs & Therapeutics for Leprosy 3

Search Clinical Trials , NIH Clinical Center for Leprosy 3

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: leprosy

Genetic Tests for Leprosy 3

Genetic tests related to Leprosy 3:

# Genetic test Affiliating Genes
1 Leprosy 3 29 TLR2

Anatomical Context for Leprosy 3

MalaCards organs/tissues related to Leprosy 3:

41
Skin, Eye, Testes, Bone, T Cells, Lung, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Leprosy 3:

19
Skin, Superficial Peripheral Nerves, Mucous Membranes Of The Upper Respiratory Tract, Anterior Chamber Of The Eyes, Testes

Publications for Leprosy 3

Articles related to Leprosy 3:

(show top 50) (show all 770)
# Title Authors Year
1
Wide Awake Tendon Transfers in Leprosy Patients in India. ( 30470333 )
2019
2
Swollen hand joints, arthralgia, photosensitivity and generalized acquired cutis laxa-like presentation of leprosy. ( 30117713 )
2018
3
Chronic, persistent angioedema and sinusitis-like presentation of multibacillary leprosy. ( 29512945 )
2018
4
Mid borderline leprosy in type Bα Blaschko linear pattern: a rare phenomenon. ( 30345504 )
2018
5
Leprosy and American cutaneous leishmaniasis coinfection. ( 29641713 )
2018
6
Widespread Dermatophytosis in a Patient Treated for Leprosy Type II Reactional State after MDT/WHO-MB Release. ( 30292246 )
2018
7
Guillain-Barre Syndrome: A Rare Presentation of Borderline Tuberculoid Leprosy with Type 1 Lepra Reaction. ( 30069105 )
2018
8
[A case series of pure neural leprosy in patients diagnosed in a specialized center for the control of Hansen's disease in Colombia]. ( 30184345 )
2018
9
Occult Hepatitis B Virus Infection in Patients with Leprosy. ( 30512182 )
2018
10
Borderline Lepromatous Leprosy: Uncommon Clinical Presentation. ( 30211733 )
2018
11
Extensive Lepromatous Lymphadenitis Preceding Lesions on the Face and Earlobes: An Unusual Presentation of Leprosy in Singapore. ( 29606944 )
2018
12
Effectiveness of the retreatment of patients with multibacillary leprosy and episodes of erythema nodosum leprosum and/or persistent neuritis: a single-center experience. ( 29723371 )
2018
13
Leprosy Neuritis. ( 29789111 )
2018
14
Borderline tuberculoid leprosy mimicking sarcoidosis: A case report. ( 30095620 )
2018
15
Second-harmonic generation imaging analysis can help distinguish sarcoidosis from tuberculoid leprosy. ( 30516038 )
2018
16
Clinical management of leprosy patients during the yellow fever outbreak in Brazil. ( 30500328 )
2018
17
Assistive technologies for improving the oral hygiene of leprosy patients residing in a former leprosy colony in Betim, Minas Gerais, Brazil. ( 30044849 )
2018
18
Characterization of New Leprosy Cases in Northeast of Iran within the Last 15 Years. ( 30046211 )
2018
19
Tuberculosis and Leprosy Coinfection: A Perspective on Diagnosis and Treatment. ( 30046638 )
2018
20
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010-2014. ( 30061618 )
2018
21
Mandating nerve biopsy: A step towards personalizing therapy in pure neuritic leprosy. ( 30070007 )
2018
22
Clinical and Histopathological Response to Multidrug Therapy in Paucibacillary Leprosy at the End of 6 Months: A Prospective Observational Study from Eastern India - a comment. ( 30078885 )
2018
23
Genetic Susceptibility to Leprosy-From Classic Immune-Related Candidate Genes to Hypothesis-Free, Whole Genome Approaches. ( 30079069 )
2018
24
New therapeutic patents used for the treatment of leprosy: a review. ( 30081970 )
2018
25
Interleukin-10 Producing Regulatory B Cells Transformed CD4+CD25- Into Tregs and Enhanced Regulatory T Cells Function in Human Leprosy. ( 30083152 )
2018
26
Mikomeseng: Leprosy, Legitimacy and Francoist Repression in Spanish Guinea. ( 30089939 )
2018
27
Complement receptor 1 (CR1, CD35) association with susceptibility to leprosy. ( 30092084 )
2018
28
Langerin (CD207)-positive cells in leprosy: Possible implications for pathogenesis of the disease with special emphasis on dermal immunoreactivity. ( 30118799 )
2018
29
Epidemiological and geographical characterization of leprosy in a Brazilian hyperendemic municipality. ( 30133668 )
2018
30
Anti-leprosy drug Clofazimine binds to human Raf1 kinase inhibitory protein and enhances ERK phosphorylation. ( 30137201 )
2018
31
Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes. ( 30143000 )
2018
32
Experts fear a resurgence of leprosy in India. ( 30152333 )
2018
33
Leprosy in individuals under the age of fifteen in priority cities, Mato Grosso, Brazil. ( 30156663 )
2018
34
IgM Anti PGL-1 Antibody Level in Patients with Leprosy: A Comparative Study between Ear Lobes Capillary and Median Cubital Vein Blood Samples. ( 30159054 )
2018
35
Lessons From Leprosy: Peripheral Neuropathies and Deformities in Chronic Demyelinating Diseases. ( 30177357 )
2018
36
Evaluation of Auramine O staining and conventional PCR for leprosy diagnosis: A comparative cross-sectional study from Ethiopia. ( 30180155 )
2018
37
A 13-Year-Old with Coexistence of Gastric Volvulus and Leprosy: A Case Report of Two Rare Entities. ( 30186647 )
2018
38
Worsening of the disability grade during leprosy treatment: prevalence and its determinants in Southern Nigeria. ( 30189090 )
2018
39
Phenotypic and functional features of innate and adaptive immunity as putative biomarkers for clinical status and leprosy reactions. ( 30195647 )
2018
40
Perception toward the disease of the people affected by leprosy. ( 30198504 )
2018
41
Prevention of Strongyloides stercoralis hyperinfection in leprosy patients on long-term steroid therapy. ( 30207326 )
2018
42
Leprosy Diagnosed Via Teledermatology in a U. S. Urban Academic Health Center Highlights Potential Benefits and a Pitfall of Existing Telemedicine Services. ( 30207893 )
2018
43
Prediction of leprosy in the Chinese population based on a weighted genetic risk score. ( 30231057 )
2018
44
Evaluation of antigen-specific immune responses for leprosy diagnosis in a hyperendemic area in China. ( 30248098 )
2018
45
Development and validation of a scale to assess attitudes of health care providers towards persons affected by leprosy in southern India. ( 30252851 )
2018
46
Impact of community-based adherence support on treatment outcomes for tuberculosis, leprosy and HIV/AIDS-infected individuals in post-Ebola Liberia. ( 30270812 )
2018
47
Epidemiology and Spatiotemporal Patterns of Leprosy Detection in the State of Bahia, Brazilian Northeast Region, 2001⁻2014. ( 30274475 )
2018
48
Polymerase Chain Reaction (PCR) as a Potential Point of Care Laboratory Test for Leprosy Diagnosis-A Systematic Review. ( 30275432 )
2018
49
Leprosy in children under 15 years of age in Brazil: A systematic review of the literature. ( 30278054 )
2018
50
Highly Reduced Genome of the New Species Mycobacterium uberis, the Causative Agent of Nodular Thelitis and Tuberculoid Scrotitis in Livestock and a Close Relative of the Leprosy Bacilli. ( 30282756 )
2018

Variations for Leprosy 3

ClinVar genetic disease variations for Leprosy 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TLR2 NM_003264.4(TLR2): c.2029C> T (p.Arg677Trp) single nucleotide variant risk factor rs121917864 GRCh37 Chromosome 4, 154626088: 154626088
2 TLR2 NM_003264.4(TLR2): c.2029C> T (p.Arg677Trp) single nucleotide variant risk factor rs121917864 GRCh38 Chromosome 4, 153704936: 153704936

Copy number variations for Leprosy 3 from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 255081 9 72339785 73251640 Duplication TRPM3 Leprosy

Expression for Leprosy 3

Search GEO for disease gene expression data for Leprosy 3.

Pathways for Leprosy 3

Pathways related to Leprosy 3 according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 IFNG IL10 IL12RB2 IL2 IL4 NOD2
2
Show member pathways
13 IFNG IL10 IL2 NOD2 TLR2 TNF
3
Show member pathways
12.8 HSPD1 IFNG IL10 IL12RB2 IL2 IL4
4
Show member pathways
12.77 IFNG IL2 IL4 TLR2 TNF
5
Show member pathways
12.6 IFNG IL10 IL12RB2 IL2 IL4 TNF
6 12.52 IFNG IL10 IL2 IL4 TLR2 TNF
7
Show member pathways
12.39 IFNG IL10 IL12RB2 IL2 IL4
8
Show member pathways
12.39 IFNG IL10 IL2 IL4 TNF
9
Show member pathways
12.32 IFNG IL2 IL4 TNF
10
Show member pathways
12.31 IFNG IL4 TLR2 TNF
11
Show member pathways
12.3 IFNG IL10 IL12RB2 IL2 IL4 NOD2
12
Show member pathways
12.24 IFNG IL10 IL2 IL4 TNF
13
Show member pathways
12.21 IFNG IL10 IL4 TLR2 TNF
14
Show member pathways
12.17 IFNG IL4 TLR2 TNF
15 12.15 HSPD1 IL10 MBD1 TNF
16 12.13 HSPD1 IFNG IL10 NOD2 TLR2 TNF
17
Show member pathways
11.99 HSPD1 IFNG IL4 TLR2 TNF
18 11.98 IFNG IL2 IL4 TNF
19
Show member pathways
11.95 IFNG IL12RB2 IL2 IL4
20 11.94 IFNG IL10 IL2 IL4 TNF
21
Show member pathways
11.91 IFNG IL10 IL12RB2 IL2 TLR2 TNF
22 11.86 IFNG IL10 IL12RB2 IL2
23 11.86 IFNG IL10 TLR2 TNF
24 11.82 IFNG TLR2 TNF
25 11.78 IFNG IL2 IL4
26
Show member pathways
11.74 IFNG IL2 IL4 TNF
27 11.72 IFNG IL10 IL2 TNF
28
Show member pathways
11.65 IFNG IL2 TNF
29
Show member pathways
11.63 IFNG IL2 TNF
30 11.62 IFNG IL10 IL2 IL4 TNF
31 11.58 HSPD1 TLR2 TNF
32 11.54 IFNG IL2 TNF
33 11.52 IL10 IL4 TNF
34 11.5 IFNG IL2 TNF
35 11.5 IFNG TLR2 TNF
36 11.5 IFNG IL10 TLR2 TNF
37 11.35 IFNG IL10 TNF
38 11.34 IFNG IL10 IL12RB2 IL2 IL4 TNF
39 11.32 IFNG IL10 IL12RB2 IL2 IL4
40 11.31 IFNG IL2 IL4
41 11.29 IFNG IL4 TNF
42 11.2 IL10 IL2 IL4 TNF
43 11.15 IFNG IL10 IL2 IL4
44 10.48 IFNG IL10 IL2 IL4 TNF

GO Terms for Leprosy 3

Cellular components related to Leprosy 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.92 HSPD1 LRRK2 TLR2 TNF

Biological processes related to Leprosy 3 according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.97 IL10 NOD2 SLC11A1 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.92 IL10 IL12RB2 IL2 IL4 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.91 IFNG IL2 LRRK2 TNF
4 positive regulation of gene expression GO:0010628 9.88 IFNG IL4 PRKN SLC11A1 TLR2 TNF
5 mitochondrion organization GO:0007005 9.87 HSPD1 LRRK2 PRKN
6 response to organic substance GO:0010033 9.86 HSPD1 IL10 TNF
7 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.86 HSPD1 HSPE1 TNF
8 negative regulation of protein phosphorylation GO:0001933 9.84 IL2 LRRK2 PRKN
9 cellular response to organic cyclic compound GO:0071407 9.83 LRRK2 NOD2 TNF
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IFNG IL2 IL4
11 response to glucocorticoid GO:0051384 9.82 HSPD1 IL10 TNF
12 positive regulation of MAP kinase activity GO:0043406 9.81 LRRK2 NOD2 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 NOD2 TLR2 TNF
14 interleukin-12-mediated signaling pathway GO:0035722 9.77 IFNG IL10 IL12RB2
15 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL10 TNF
17 cellular response to dopamine GO:1903351 9.7 LRRK2 PRKN
18 positive regulation of tumor necrosis factor secretion GO:1904469 9.69 HSPD1 LRRK2
19 positive regulation of interleukin-8 production GO:0032757 9.69 NOD2 TLR2 TNF
20 positive regulation of interleukin-17 production GO:0032740 9.68 IL2 NOD2
21 positive regulation of protein import into nucleus, translocation GO:0033160 9.68 IFNG LRRK2
22 response to molecule of bacterial origin GO:0002237 9.68 IL10 TLR2
23 positive regulation of isotype switching to IgG isotypes GO:0048304 9.67 IL2 IL4
24 positive regulation of inflammatory response GO:0050729 9.67 HSPD1 IL2 TLR2 TNF
25 cellular response to manganese ion GO:0071287 9.66 LRRK2 PRKN
26 positive regulation of programmed cell death GO:0043068 9.66 LRRK2 TNF
27 response to lipopolysaccharide GO:0032496 9.65 HSPD1 IL10 IL12RB2 SLC11A1 TLR2
28 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
29 positive regulation of dendritic cell antigen processing and presentation GO:0002606 9.63 NOD2 SLC11A1
30 positive regulation of interleukin-12 production GO:0032735 9.63 HSPD1 IFNG TLR2
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL10 IL4
32 protein localization to mitochondrion GO:0070585 9.62 LRRK2 PRKN
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
34 positive regulation of interleukin-10 production GO:0032733 9.61 HSPD1 NOD2 TLR2
35 regulation of isotype switching GO:0045191 9.58 IL10 IL4
36 type 2 immune response GO:0042092 9.58 IL10 IL4
37 cytokine secretion involved in immune response GO:0002374 9.57 NOD2 TLR2
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IFNG TNF
39 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
40 regulation of synaptic vesicle transport GO:1902803 9.54 LRRK2 PRKN
41 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.5 LRRK2 NOD2 TLR2
42 immune response GO:0006955 9.5 IFNG IL10 IL2 IL4 SLC11A1 TLR2
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.49 IFNG TNF
44 positive regulation of interleukin-6 production GO:0032755 9.46 HSPD1 NOD2 TLR2 TNF
45 positive regulation of interferon-gamma production GO:0032729 9.02 HSPD1 IL12RB2 IL2 SLC11A1 TNF
46 positive regulation of transcription by RNA polymerase II GO:0045944 10.08 IL10 IL2 IL4 NOD2 PRKN SLC11A1
47 regulation of signaling receptor activity GO:0010469 10.04 IFNG IL10 IL2 IL4 TNF

Molecular functions related to Leprosy 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Hsp70 protein binding GO:0030544 9.33 NOD2 PACRG PRKN
2 chaperone binding GO:0051087 9.26 HSPD1 HSPE1 PACRG PRKN
3 cytokine activity GO:0005125 9.02 IFNG IL10 IL2 IL4 TNF

Sources for Leprosy 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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