LPRS4
MCID: LPR016
MIFTS: 15

Leprosy 4 (LPRS4)

Categories: Eye diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Leprosy 4

MalaCards integrated aliases for Leprosy 4:

Name: Leprosy 4 57
Leprosy, Susceptibility to, 4 57 28 12
Leprosy, Type 4 38
Lprs4 57

Classifications:



External Ids:

OMIM® 57 610988

Summaries for Leprosy 4

MalaCards based summary: Leprosy 4, also known as leprosy, susceptibility to, 4, is related to leprosy 3 and lepromatous leprosy. An important gene associated with Leprosy 4 is LTA (Lymphotoxin Alpha). Affiliated tissues include skin.

More information from OMIM: 610988

Related Diseases for Leprosy 4

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 4 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leprosy 3 10.1
2 lepromatous leprosy 9.9

Symptoms & Phenotypes for Leprosy 4

Clinical features from OMIM®:

610988 (Updated 08-Dec-2022)

Drugs & Therapeutics for Leprosy 4

Search Clinical Trials, NIH Clinical Center for Leprosy 4

Genetic Tests for Leprosy 4

Genetic tests related to Leprosy 4:

# Genetic test Affiliating Genes
1 Leprosy, Susceptibility to, 4 28 LTA

Anatomical Context for Leprosy 4

Organs/tissues related to Leprosy 4:

MalaCards : Skin

Publications for Leprosy 4

Articles related to Leprosy 4:

(show all 16)
# Title Authors PMID Year
1
Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy. 57
17353895 2007
2
Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. 57
15052269 2004
3
Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. 57
14735151 2004
4
Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population. 57
12577057 2003
5
Tumor necrosis factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients. 57
11261930 2001
6
Blood RNA signature RISK4LEP predicts leprosy years before clinical onset. 62
34090257 2021
7
Estimation of serum level of interleukin-17 and interleukin-4 in leprosy, towards more understanding of leprosy immunopathogenesis. 62
24177608 2013
8
Serodiagnosis of tuberculosis: specific detection of free and complex-dissociated antibodies anti-mycobacterium tuberculosis recombinant antigens. 62
18833409 2008
9
Infection and disease caused by environmental mycobacteria. 62
11981303 2002
10
Articular inflammatory manifestations in patients with different forms of leprosy. 62
9458213 1998
11
Cytomorphology of leprosy across the Ridley-Jopling spectrum. 62
8693892 1996
12
Renal abnormality in leprosy. 62
6632783 1983
13
Experimental murine leprosy. 4. The gross appearance and microscopic features of the local infiltrate after subcutaneous inoculation of C3H and C57/BL mice with mycobacterium lepraemurium. 62
1092129 1975
14
Chemotherapeutic trials in leprosy. 4. Dapsone (DDS) in low dosage in the treatment of lepromatous leprosy. A demonstration pilot study. 62
5338958 1967
15
Clinical evaluation studies in lepromatous leprosy. 4. 4, Butoxy-4'dimethylaminodiphenyl thiourea (DPT), amodiaquin, and 4-4'diaminodiphenyl sulfone (DDS) 2.5 mgm, and 4 mgm. per kg. of body weight. 62
13887566 1961
16
Chemotherapy of murine leprosy. 4. The effects of isonicotinoyl-3, 4-diethoxybenzal hydrazone on murine leprosy. 62
13669524 1959

Variations for Leprosy 4

Expression for Leprosy 4

Search GEO for disease gene expression data for Leprosy 4.

Pathways for Leprosy 4

GO Terms for Leprosy 4

Sources for Leprosy 4

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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