LPRS5
MCID: LPR017
MIFTS: 18

Leprosy 5 (LPRS5)

Categories: Endocrine diseases, Eye diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Reproductive diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Leprosy 5

MalaCards integrated aliases for Leprosy 5:

Name: Leprosy 5 57 29 6
Leprosy, Protection Against 57 13 6
Leprosy, Susceptibility to, 5 57
Leprosy, Type 5 39
Lprs5 57

Classifications:



External Ids:

OMIM® 57 613223

Summaries for Leprosy 5

MalaCards based summary : Leprosy 5, also known as leprosy, protection against, is related to leprosy 3 and hansen's disease. An important gene associated with Leprosy 5 is TLR1 (Toll Like Receptor 1). Affiliated tissues include neutrophil.

More information from OMIM: 613223

Related Diseases for Leprosy 5

Diseases in the Leprosy 3 family:

Leprosy 2 Leprosy 1
Leprosy 4 Leprosy 5
Leprosy 6

Diseases related to Leprosy 5 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leprosy 3 10.1
2 hansen's disease 10.1
3 lepromatous leprosy 9.8

Symptoms & Phenotypes for Leprosy 5

Clinical features from OMIM®:

613223 (Updated 05-Apr-2021)

Drugs & Therapeutics for Leprosy 5

Search Clinical Trials , NIH Clinical Center for Leprosy 5

Genetic Tests for Leprosy 5

Genetic tests related to Leprosy 5:

# Genetic test Affiliating Genes
1 Leprosy 5 29 TLR1

Anatomical Context for Leprosy 5

MalaCards organs/tissues related to Leprosy 5:

40
Neutrophil

Publications for Leprosy 5

Articles related to Leprosy 5:

(show all 24)
# Title Authors PMID Year
1
Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. 6 57
19456232 2009
2
Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. 57 6
18461142 2008
3
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. 6 57
17548585 2007
4
The polymorphism P315L of human toll-like receptor 1 impairs innate immune sensing of microbial cell wall components. 6 57
17475868 2007
5
A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis. 6
26729809 2016
6
Differential trafficking of TLR1 I602S underlies host protection against pathogenic mycobacteria. 6
23105135 2012
7
Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14. 57
8838819 1996
8
Role of s-100 immunostaining in demonstration of nerve changes and quantification of dendritic cells in leprosy. 61
24783075 2014
9
Evaluation of qPCR-based assays for leprosy diagnosis directly in clinical specimens. 61
22022631 2011
10
Leprosy in the Department of Dermatology, Chang Gung Memorial Hospital at Kaohsiung from 1988 to 2004: a clinical and histopathologic study of 13 cases. 61
16382756 2005
11
Renal lesions in leprosy: a retrospective study of 199 autopsies. 61
11431177 2001
12
Effect of HIV infection on the clinical spectrum of leprosy in Maiduguri. 61
11487905 2001
13
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. 61
10677479 2000
14
CT findings in involvement of the paranasal sinuses by lepromatous leprosy. 61
10396217 1999
15
Relapse in a borderline-tuberculoid case of leprosy 5 years after the release from rifampicin monotherapy. 61
9217356 1997
16
Nucleotide sequence analysis and seroreactivities of the 65K heat shock protein from Mycobacterium paratuberculosis. 61
8574825 1995
17
Relapse with multibacillary leprosy caused by rifampicin sensitive organisms following paucibacillary multidrug therapy. 61
7500815 1995
18
Tuberculosis in leprosy patients detected between 1902 and 1991 in French Polynesia. 61
8371028 1993
19
Renal transplantation in leprosy patients. 61
8326170 1993
20
Serum beta-glucuronidase in subtypes of leprosy. 61
2345017 1990
21
Leprosy, liver and jaundice. 61
3116106 1987
22
Phagocytosis in leprosy. 5. The effect of the infection with Mycobacterium lepraemurium on the level of diverse hydrolytic lysosomal enzymes of murine peritoneal macrophages. 61
6890533 1982
23
Chemotherapeutic trials in leprosy. 5. A study of methods used in clinical trials in lepromatous leprosy. 61
4917107 1967
24
[Relation between host resistance and disease type in murine leprosy. 5. Influence of vaccination with killed bacilli on the development of subcutaneous leproma]. 61
14454543 1961

Variations for Leprosy 5

ClinVar genetic disease variations for Leprosy 5:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TLR1 NM_003263.4(TLR1):c.1805G>T (p.Ser602Ile) SNV protective 8360 rs5743618 GRCh37: 4:38798648-38798648
GRCh38: 4:38797027-38797027
2 TLR1 NM_003263.4(TLR1):c.743A>G (p.Asn248Ser) SNV risk factor 8361 rs4833095 GRCh37: 4:38799710-38799710
GRCh38: 4:38798089-38798089

Expression for Leprosy 5

Search GEO for disease gene expression data for Leprosy 5.

Pathways for Leprosy 5

GO Terms for Leprosy 5

Sources for Leprosy 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....