LEPQTL1
MCID: LPT013
MIFTS: 13

Leptin, Serum Level of, Quantitative Trait Locus 1 (LEPQTL1)

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Aliases & Classifications for Leptin, Serum Level of, Quantitative Trait Locus 1

MalaCards integrated aliases for Leptin, Serum Level of, Quantitative Trait Locus 1:

Name: Leptin, Serum Level of, Quantitative Trait Locus 1 57
Leptin Serum Levels Qtl1 57 12
Lsl 57 75
Lepqtl1 57

External Ids:

OMIM® 57 601694

Summaries for Leptin, Serum Level of, Quantitative Trait Locus 1

OMIM®: 57 Leptin (LEP; 164160) is a serum protein produced by adipocytes and is thought to play a role in the regulation of body fat. Leptin levels in humans are highly correlated with the individual's total adiposity (Maffei et al., 1995; Considine et al., 1996). (601694) (Updated 08-Dec-2022)

MalaCards based summary: Leptin, Serum Level of, Quantitative Trait Locus 1, also known as leptin serum levels qtl1, is related to type 2 diabetes mellitus and bulimia nervosa. An important gene associated with Leptin, Serum Level of, Quantitative Trait Locus 1 is LEPQTL1 (Leptin, Serum Levels Of).

Wikipedia: 75 Leptin, serum levels of, also known as LSL, is a human... more...

Related Diseases for Leptin, Serum Level of, Quantitative Trait Locus 1

Diseases related to Leptin, Serum Level of, Quantitative Trait Locus 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 type 2 diabetes mellitus 11.1
2 bulimia nervosa 11.1
3 hypothyroidism 11.1
4 hyperinsulinism 11.1
5 osteoporosis 11.0
6 prader-willi syndrome 11.0
7 type 1 diabetes mellitus 11.0
8 anorexia nervosa 11.0
9 protein-energy malnutrition 11.0
10 chronic kidney disease 11.0
11 eating disorder 11.0
12 laron syndrome 10.9
13 insulin-like growth factor i 10.9
14 body mass index quantitative trait locus 11 10.9
15 resting heart rate, variation in 10.9
16 myelodysplastic syndrome 10.9
17 congenital generalized lipodystrophy 10.9
18 marasmus 10.9
19 coccidioidomycosis 10.9
20 cerebral palsy 10.9
21 nutritional deficiency disease 10.9
22 fetal macrosomia 10.9
23 pancreatic cancer 10.5
24 pancreatic ductal adenocarcinoma 10.5
25 microphthalmia, syndromic 9 10.5
26 adenocarcinoma 10.2
27 pancreatitis, hereditary 10.0
28 pancreatic adenocarcinoma 10.0
29 pancreatitis 10.0
30 glaucoma, primary open angle 9.9
31 short stature, auditory canal atresia, mandibular hypoplasia, and skeletal abnormalities 9.9
32 creatinine clearance quantitative trait locus 9.9
33 spastic paraplegia, ataxia, and mental retardation 9.9
34 lung cancer susceptibility 3 9.9
35 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 9.9
36 leptin deficiency or dysfunction 9.9
37 b-lymphoblastic leukemia/lymphoma 9.9
38 open-angle glaucoma 9.9
39 exostosis 9.9

Graphical network of the top 20 diseases related to Leptin, Serum Level of, Quantitative Trait Locus 1:



Diseases related to Leptin, Serum Level of, Quantitative Trait Locus 1

Symptoms & Phenotypes for Leptin, Serum Level of, Quantitative Trait Locus 1

Clinical features from OMIM®:

601694 (Updated 08-Dec-2022)

Drugs & Therapeutics for Leptin, Serum Level of, Quantitative Trait Locus 1

Search Clinical Trials, NIH Clinical Center for Leptin, Serum Level of, Quantitative Trait Locus 1

Genetic Tests for Leptin, Serum Level of, Quantitative Trait Locus 1

Anatomical Context for Leptin, Serum Level of, Quantitative Trait Locus 1

Publications for Leptin, Serum Level of, Quantitative Trait Locus 1

Articles related to Leptin, Serum Level of, Quantitative Trait Locus 1:

# Title Authors PMID Year
1
Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC. 57
10487685 1999
2
The quantitative trait locus on chromosome 2 for serum leptin levels is confirmed in African-Americans. 57
10078570 1999
3
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. 57
9054940 1997
4
Serum immunoreactive-leptin concentrations in normal-weight and obese humans. 57
8532024 1996
5
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. 57
7584987 1995

Variations for Leptin, Serum Level of, Quantitative Trait Locus 1

Expression for Leptin, Serum Level of, Quantitative Trait Locus 1

Search GEO for disease gene expression data for Leptin, Serum Level of, Quantitative Trait Locus 1.

Pathways for Leptin, Serum Level of, Quantitative Trait Locus 1

GO Terms for Leptin, Serum Level of, Quantitative Trait Locus 1

Sources for Leptin, Serum Level of, Quantitative Trait Locus 1

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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