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MCID: LPT001
MIFTS: 66

Leptospirosis

Categories: Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Leptospirosis

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MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 12 74 52 58 54 3 43 15 17 71 32
Weil Disease 52 43 71
Leptospirosis Icterohaemorrhagica 12 32
Hemorrhagic Jaundice 52 71
Stuttgart Disease 52 71
Fort Bragg Fever 12 71
Canicola Fever 52 71
Equine Infectious Anemia 71
Icterohemorrhagic Fever 52
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 71
Swineherd's Disease 52
Cane-Cutter Fever 52
Nanukayami Fever 12
Rice-Field Fever 52
Weil's Disease 12
Weil Syndrome 74
Swamp Fever 52
Nanukayami 71
Mud Fever 52

Characteristics:

Orphanet epidemiological data:

58
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases Liver diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


Sources

Summaries for Leptospirosis

About this section
CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all. Without treatment, Leptospirosis can lead to kidney damage, meningitis (inflammation of the membrane around the brain and spinal cord), liver failure, respiratory distress, and even death.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to dengue disease and acute kidney failure. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Emtricitabine and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and liver, and related phenotypes are nausea and vomiting and hypotension

Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

Wikipedia : 74 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Sources

Related Diseases for Leptospirosis

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Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 897)
# Related Disease Score Top Affiliating Genes
1 dengue disease 32.6 TNF PIK3C2A CD40LG
2 acute kidney failure 31.1 SLC9A3 PIK3C2A LCN2 IL18 F2
3 cardiogenic shock 31.0 IL6 CRP
4 epidemic typhus 30.9 TLR2 CRP CD40LG
5 bilirubin metabolic disorder 30.9 F2 CRP CD40LG
6 acalculous cholecystitis 30.8 F2 CRP CD40LG
7 disseminated intravascular coagulation 30.7 TNF PIK3C2A IL6 IL10 F2 CRP
8 acute myocarditis 30.6 IL6 IL10 CRP
9 plague 30.5 TNF TLR2 IL6 IL10
10 iridocyclitis 30.5 TNF IL6 CRP CD40LG
11 hantavirus hemorrhagic fever with renal syndrome 30.4 TNF IL6 CRP CD40LG
12 adult respiratory distress syndrome 30.4 TNF IL6 IL1B IL10 F2 CXCL8
13 meningoencephalitis 30.4 TNF IL6 IL10 CRP CD40LG
14 transverse myelitis 30.4 TNF IL6 IL10 CXCL8
15 anuria 30.4 PIK3C2A LCN2 F2 CRP CD40LG
16 deficiency anemia 30.4 TNF PIK3C2A LCN2 IL6 CRP
17 hepatitis a 30.3 TNF IL4 IL10 IFNG F2
18 cavernous sinus thrombosis 30.3 F2 CRP
19 congestive heart failure 30.3 TNF PIK3C2A IL6 CRP
20 optic neuritis 30.2 TNF IL1B IL10 CXCL8
21 systemic autoimmune disease 30.2 IL6 CRP
22 intussusception 30.2 IL6 CRP CD40LG
23 kidney disease 30.2 TNF SLC12A1 LCN2 IL6 IL18 CRP
24 lemierre's syndrome 30.2 F2 CRP
25 crimean-congo hemorrhagic fever 30.2 TNF PIK3C2A IL6
26 cholera 30.2 TNF IL6 IL4 CXCL8
27 spotted fever rickettsiosis 30.1 TNF IL10 IFNG
28 panuveitis 30.1 TNF IL6 IL10 CRP CD40LG
29 antiphospholipid syndrome 30.1 TNF F2 CRP CD40LG
30 neuroretinitis 30.1 IFNG CRP CD40LG
31 pulmonary edema 30.1 TNF PIK3C2A IL1B IL10 F2 CXCL8
32 fatty liver disease 30.1 TNF IL6 IL1B CXCL8 CRP
33 obstructive jaundice 30.1 TNF IL6 F2 CXCL8 CRP
34 mastitis 30.1 TLR2 IL6 IL18 CXCL8
35 spondylitis 30.0 TNF IL6 IL10 IFNG CRP
36 uveitis 30.0 TNF IL6 IL4 IL10 IFNG CXCL8
37 aseptic meningitis 30.0 TNF IL1B IL10 IFNG CXCL8 CD40LG
38 nutritional deficiency disease 30.0 IL6 F2 CRP
39 chronic kidney disease 30.0 TNF LCN2 IL6 IL10 CRP CCL2
40 splenic infarction 30.0 F2 CRP CD40LG
41 acute disseminated encephalomyelitis 30.0 IL1B IL10 CD40LG
42 trachoma 30.0 TNF IL6 IL4 IL10
43 avian influenza 30.0 TNF IL6 CXCL8
44 posterior uveitis 30.0 TNF IL6 IL4 IFNG
45 intracranial hypertension 30.0 TNF IL1B F2 AQP1
46 thrombophlebitis 29.9 F2 CRP CD40LG
47 poliomyelitis 29.9 TNF IL4 IL10 IFNG CD40LG
48 myelitis 29.9 TNF IL6 IL10 CXCL8 CD40LG
49 thrombocytosis 29.9 IL6 IL1B F2 CRP
50 encephalitis 29.9 TNF IL6 IL1B IL10 CD40LG CCL2

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis
Sources

Symptoms & Phenotypes for Leptospirosis

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Human phenotypes related to Leptospirosis:

58 31 (show all 40)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
2 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
3 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
4 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
5 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
6 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
7 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
8 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
9 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
10 hyperproteinemia 58 31 frequent (33%) Frequent (79-30%) HP:0002152
11 elevated serum transaminases during infections 58 31 frequent (33%) Frequent (79-30%) HP:0008150
12 conjunctival hyperemia 58 31 frequent (33%) Frequent (79-30%) HP:0030953
13 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
14 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
15 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
16 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
17 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
18 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
19 first degree atrioventricular block 58 31 occasional (7.5%) Occasional (29-5%) HP:0011705
20 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
21 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
22 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
23 acute kidney injury 58 31 occasional (7.5%) Occasional (29-5%) HP:0001919
24 lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002716
25 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
26 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
27 pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0025439
28 cellular urinary casts 58 31 occasional (7.5%) Occasional (29-5%) HP:0031197
29 pulmonary hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0040223
30 arrhythmia 58 31 very rare (1%) Very rare (<4-1%) HP:0011675
31 pericarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0001701
32 uveitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000554
33 papilledema 58 31 very rare (1%) Very rare (<4-1%) HP:0001085
34 retinal hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0000573
35 optic neuritis 58 31 very rare (1%) Very rare (<4-1%) HP:0100653
36 rhabdomyolysis 58 31 very rare (1%) Very rare (<4-1%) HP:0003201
37 subconjunctival hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0011896
38 chorioretinitis 58 31 very rare (1%) Very rare (<4-1%) HP:0012424
39 macular cotton wool spot 58 31 very rare (1%) Very rare (<4-1%) HP:0030497
40 morphological abnormality of the central nervous system 58 Occasional (29-5%)

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.88 AQP1 CD40LG CXCL8 F2 IL10 IL18
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.88 AQP1 CD40LG CXCL8 F2 IL10 IL18

MGI Mouse Phenotypes related to Leptospirosis:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.4 AQP1 CD40LG CRP F2 IFNG IL10
2 hematopoietic system MP:0005397 10.36 AQP1 CD40LG F2 IFNG IL10 IL18
3 homeostasis/metabolism MP:0005376 10.34 AQP1 CD40LG CRP F2 IFNG IL10
4 immune system MP:0005387 10.33 CCL2 CD40LG CRP F2 IFNG IL10
5 growth/size/body region MP:0005378 10.29 AQP1 F2 IFNG IL10 IL18 IL1B
6 endocrine/exocrine gland MP:0005379 10.24 AQP1 CD40LG IFNG IL10 IL4 IL6
7 mortality/aging MP:0010768 10.17 AQP1 CD40LG F2 IFNG IL10 IL18
8 digestive/alimentary MP:0005381 10.16 F2 IFNG IL10 IL18 IL4 IL6
9 integument MP:0010771 10.11 CD40LG F2 IFNG IL10 IL18 IL1B
10 adipose tissue MP:0005375 10.08 IL18 IL6 LCN2 PIK3C2A SLC9A3 TLR2
11 renal/urinary system MP:0005367 9.96 AQP1 CD40LG IFNG IL4 IL6 LCN2
12 reproductive system MP:0005389 9.93 AQP1 CD40LG F2 IFNG IL10 IL4
13 respiratory system MP:0005388 9.61 AQP1 F2 IFNG IL10 IL4 IL6
14 skeleton MP:0005390 9.36 AQP1 CD40LG F2 IFNG IL10 IL1B
Sources

Drugs & Therapeutics for Leptospirosis

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Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
4 Anti-Bacterial Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Anti-Retroviral Agents Phase 4
7 Antiparasitic Agents Phase 4
8 Antiviral Agents Phase 4
9 Antiprotozoal Agents Phase 4
10 Reverse Transcriptase Inhibitors Phase 4
11 Antimalarials Phase 4
12 Anti-HIV Agents Phase 4
13
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
14
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
15 Antiemetics Phase 2, Phase 3
16 HIV Protease Inhibitors Phase 2, Phase 3
17 Arginine Vasopressin Phase 2, Phase 3
18 Gastrointestinal Agents Phase 2, Phase 3
19
protease inhibitors Phase 2, Phase 3
20 BB 1101 Phase 2, Phase 3
21 Hormone Antagonists Phase 2, Phase 3
22 Hemostatics Phase 2, Phase 3
23 Deamino Arginine Vasopressin Phase 2, Phase 3
24 Autonomic Agents Phase 2, Phase 3
25 Anti-Inflammatory Agents Phase 2, Phase 3
26 Vasopressins Phase 2, Phase 3
27 Antineoplastic Agents, Hormonal Phase 2, Phase 3
28 Natriuretic Agents Phase 2, Phase 3
29 glucocorticoids Phase 2, Phase 3
30 Hormones Phase 2, Phase 3
31 Coagulants Phase 2, Phase 3
32
Arginine Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322
33
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
34
Mebendazole Approved, Vet_approved 31431-39-7 4030
35
Albendazole Approved, Vet_approved 54965-21-8 2082
36
Ethanol Approved 64-17-5 702
37 Vaccines
38 Immunologic Factors
39 Immunoglobulins
40 Antibodies
41 Immunoglobulin G
42 Immunoglobulin M
43 Antitubercular Agents
44 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial). Active, not recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
2 An Open Randomized Controlled Trial of Desmopressin, and Dexamethasone as Adjunctive Therapy in Patients With Pulmonary Hemorrhage Associated With Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
3 Serological Response in Patients Infected by Leptospirosis 1 to 7 Years Earlier Unknown status NCT02898519
4 Severe Leptospirosis in Non-tropical Areas: a Nationwide, Multicentre, Retrospective Study in French ICUs Completed NCT03912506
5 Seroprevalence, Multi-center, Phase IV Cross-sectional Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Completed NCT03497572
6 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
7 Indian Intensive Care Case Mix and Practice Patterns Study Completed NCT01384929
8 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
9 The Impact of C-reactive Protein Testing on Antibiotic Prescription in Febrile Patients Attending Primary Care in Low-resource Settings Completed NCT02758821
10 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Recruiting NCT02000635
11 Utility of Quantitative Polymerase Chain Reaction to Predict Clinical Outcome of Leptospirosis in French West Indies Active, not recruiting NCT01607047
12 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Active, not recruiting NCT02089152
13 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Active, not recruiting NCT03269266
14 Cohort of Hospitalized Patients Suspected of Leptospirosis Not yet recruiting NCT04034550

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

Sources

Genetic Tests for Leptospirosis

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Sources

Anatomical Context for Leptospirosis

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MalaCards organs/tissues related to Leptospirosis:

40
Testes, Kidney, Liver, Lung, Heart, Bone, Brain
Sources

Publications for Leptospirosis

About this section

Articles related to Leptospirosis:

(show top 50) (show all 7112)
# Title Authors PMID Year
1
Nephropathia epidemica and leptospirosis in Champagne-Ardenne, France: comparison of clinical, biological and epidemiological profiles. 54 61
19229563 2009
2
Evaluation of leptospiral recombinant antigens MPL17 and MPL21 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays. 54 61
18799647 2008
3
Recombinant multiepitope protein for diagnosis of leptospirosis. 54 61
18827193 2008
4
Leptospirosis vaccines. 54 61
18072968 2007
5
Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology. 54 61
16433137 2005
6
Leptospirosis presenting with mania and psychosis: four consecutive cases seen in a military hospital in Turkey. 54 61
16480244 2005
7
Preliminary survey of leptospirosis amongst febrile patients from urban slums of East Delhi. 54 61
12839344 2003
8
Evaluation of the clinical utility of a rapid blood test for human leptospirosis. 54 61
12007438 2002
9
Evaluation of recombinant Leptospira antigen-based enzyme-linked immunosorbent assays for the serodiagnosis of leptospirosis. 54 61
11526167 2001
10
Lateral-flow assay for rapid serodiagnosis of human leptospirosis. 54 61
11139212 2001
11
International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human serum specimens. 54 61
10449473 1999
12
Field evaluation of a one-step dipstick assay for the diagnosis of human leptospirosis in the Seychelles. 54 61
10203172 1999
13
Macroscopic agglutination test for rapid diagnosis of human leptospirosis. 54 61
9774553 1998
14
Evaluation of the indirect hemagglutination assay for diagnosis of acute leptospirosis. 54 61
9431911 1998
15
Increased inflammation with crude E. coli LPS protects against acute leptospirosis in hamsters. 61
31914888 2020
16
Estimation of the burden of leptospirosis in New Zealand. 61
31799801 2020
17
The epidemiology, characteristics and outbreaks of human leptospirosis and the association with animals in Taiwan, 2007-2014: A nationwide database study. 61
31916706 2020
18
Investigation and response to an outbreak of leptospirosis among raspberry workers in Australia, 2018. 61
31550083 2020
19
The "MICE" scoring system in differentiating the identical twins leptospirosis and hantavirus infection. 61
31656011 2020
20
Significant Clinical Presentation of Leptospirosis in Relation to Sociodemographic and Risk Factors in a Tertiary Hospital, Malaysia. 61
32013800 2020
21
Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil. 61
31961288 2020
22
Raccoons (Procyon lotor) and Striped Skunks (Mephitis mephitis) as Potential Reservoirs of Leptospira spp. in California. 61
32017860 2020
23
Poly(diaminosulfide) Microparticle-Based Vaccine for Delivery of Leptospiral Antigens. 61
31895553 2020
24
High frequency of seropositive and carriers of Leptospira spp. in pigs in the semiarid region of northeastern Brazil. 61
32026195 2020
25
Elevated levels of IL-8 in fatal leptospirosis. 61
32024441 2020
26
An overview of human leptospirosis vaccine design and future perspectives. 61
31777290 2020
27
Leopold Kirschner, Edward Sayers, and Neil Bruère: the initial descriptions of leptospirosis in New Zealand. 61
31667900 2020
28
Hypocalcemia, hypochloremia, and eosinopenia as clinical predictors of leptospirosis: A retrospective study. 61
31455598 2020
29
Emergence of murine typhus in La Réunion, France, 2012-2017. 61
31387814 2020
30
Microscopic agglutination test: Variables that affect the time of serological confirmation of human leptospirosis cases. 61
31959371 2020
31
Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review. 61
31898795 2020
32
Identification of compounds for improved growth of Leptospira in culture and isolation. 61
31704065 2020
33
A canine vaccine against Leptospira serovars Icterohaemorrhagiae, Canicola and Grippotyphosa provides cross protection against Leptospira serovar Copenhageni. 61
31759261 2020
34
Restructuring the Modified Faine's Criteria for the Diagnosis of Leptospirosis in Monsoon: A Study from South Gujarat. 61
32029982 2020
35
Pregnancy Loss Due To Amnionitis In Anglo-Arabian Mare- Case Report. 61
31916285 2020
36
Leptospiral shedding and seropositivity in shelter dogs in the Cumberland Gap Region of Southeastern Appalachia. 61
31999733 2020
37
Serological and molecular characterization of Leptospira kirschneri serogroup Grippotyphosa isolated from bovine in Brazil. 61
31626918 2020
38
A systematic review of Leptospira in water and soil environments. 61
31986154 2020
39
Molecular epidemiology of Leptospira noguchii reveals important insights into a One Health context. 61
31484225 2020
40
Leptospirosis presented with erythema nodosum on four limbs: an unusual presenting. 61
32038875 2020
41
Seroprevalence and risk factors associated with equineleptospirosis in the metropolitan region of Salvador and Recôncavo Baiano region, Bahia state (NE Brazil). 61
31289965 2020
42
Leptospirosis: Increasing importance in developing countries. 61
31542372 2020
43
Improving the mortality of severe leptospirosis. 61
31960067 2020
44
Monoclonal antibodies against LipL32 confer prophylactic protection against lethal leptospirosis challenge in animal model. 61
31931114 2020
45
Development and Validation of a simple score for diagnosis of Leptospirosis at outpatient departments. 61
31917796 2020
46
Serological evidence of leptospirosis in Iran; A systematic review and meta-analysis. 61
31698052 2020
47
Investigation of Leptospira Infection in Stray Animals in Songkhla, Thailand: Leptospirosis Risk Reduction in Human. 61
31905047 2020
48
Clinical presentations and predictors of mortality for leptospirosis - A study from suburban area in Malaysia. 61
32008021 2020
49
Genital bovine leptospirosis: A new look for an old disease. 61
31518727 2020
50
Searching and finding the hidden treasure: Rickettsial disease among Dutch international travelers - a retrospective analysis. 61
31998942 2020
Sources

Variations for Leptospirosis

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Expression for Leptospirosis

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Search GEO for disease gene expression data for Leptospirosis.
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Pathways for Leptospirosis

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Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.16 TNF TLR2 TLR1 PTX3 LCN2 IL6
2
PEDF Induced Signaling 63
Show member pathways
 13.79 TNF IL6 IL4 IL1B IL18 IL10
3
TGF-Beta Pathway 63
Show member pathways
 13.65 TNF IL6 IL4 IL1B IL18 IL10
4
Akt Signaling 63
Show member pathways
 13.55 TNF TLR2 TLR1 IL6 IL4 IL1B
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.5 TNF LCN2 IL6 IL4 IL1B IL18
6
PAK Pathway 63
Show member pathways
 13.43 TNF IL6 IL4 IL1B IL18 IL10
7
IL-2 Pathway 63
Show member pathways
 13.29 TNF TLR2 TLR1 PIK3C2A IL4 IL1B
8
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.28 TNF TLR2 TLR1 IL6 IL1B IL18
9
Human cytomegalovirus infection 36
Show member pathways
 13.02 TNF TLR2 IL6 IL1B CXCL8 CCL2
10
Allograft rejection 1 36
Show member pathways
 13.02 TNF IL6 IL4 IL1B IL10 IFNG
11
Measles 36
Show member pathways
 12.98 TNF TLR2 IL6 IL1B IL18 IFNG
12
Herpes simplex virus 1 infection 36
12.91 TNF TLR2 IL6 IL1B IFNG CCL2
13
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.87 TNF IL6 IL1B IL18 IFNG CXCL8
14
NF-KappaB Family Pathway 63
Show member pathways
 12.82 TNF TLR2 TLR1 IL6 IL1B CD40LG
15
T cell receptor signaling pathway 36
Show member pathways
 12.79 TNF TLR2 IL6 IL4 IL1B IL10
16
Th17 cell differentiation 36
Show member pathways
 12.78 TNF TLR2 IL6 IL4 IL1B IL18
17
Immune response NFAT in immune response 22
Show member pathways
 12.76 TNF IL4 IL18 IL10 IFNG CD40LG
18
Immune response IL-23 signaling pathway 22
Show member pathways
 12.76 TNF IL6 IL1B IL18 IL10 IFNG
19
NF-kappaB Signaling 4
12.74 TNF TLR2 TLR1 IL4 IL1B IL10
20
TRAF Pathway 63
Show member pathways
 12.68 TNF TLR2 TLR1 IL1B CD40LG
21
Folate Metabolism 1
Show member pathways
 12.53 TNF IL6 IL4 IL1B IFNG F2
22
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.51 TNF IL6 IL18 IL10 CXCL8 CCL2
23
Pathogenic Escherichia coli infection 36
12.48 TNF IL6 IL1B IL18 F2 CXCL8
24
Shigellosis 36
12.44 TNF IL1B IL18 CXCL8
25
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.44 TNF IL6 IL4 IL1B IL18 IL10
26
Toxoplasmosis 36
Show member pathways
 12.44 TNF TLR2 IL4 IL1B IL10 IFNG
27
Toll Comparative Pathway 63
Show member pathways
 12.43 TNF IL6 IL1B IFNG CXCL8
28
NOD-like receptor signaling pathway 36
12.43 TNF IL6 IL1B IL18 CXCL8 CCL2
29
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.42 IL6 IL4 IL10 IFNG
30
Tuberculosis 36
12.42 TNF TLR2 TLR1 IL6 IL1B IL18
31
IL-17 Family Signaling Pathways 64
Show member pathways
 12.42 TNF TLR2 LCN2 IL6 IL4 IL1B
32
IL-1 Family Signaling Pathways 64
Show member pathways
 12.41 TNF TLR2 IL6 IL1B IL18 CXCL8
33
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.4 TNF TLR2 TLR1 IL6 CXCL8
34
Bacterial infections in CF airways 22
Show member pathways
 12.37 TNF TLR2 TLR1 IL6 IL4 IL1B
35
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.35 TNF SLC9A3 IL6 IL1B IL10 CXCL8
36
Colorectal Cancer Metastasis 63
12.33 TNF TLR2 TLR1 IL6 IFNG
37
C-type lectin receptor signaling pathway 36
Show member pathways
 12.3 TNF IL6 IL1B IL10
38
Yersinia infection 36
12.22 TNF IL6 IL1B IL18 IL10 CXCL8
39
Th1 Differentiation Pathway 64
Show member pathways
 12.21 TNF TLR2 TLR1 IL6 IL1B IL18
40
Fluid shear stress and atherosclerosis 36
12.19 TNF IL1B IFNG CCL2
41
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.17 TNF IL6 IL4 IL10 IFNG
42
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.16 TNF TLR2 TLR1 IL6 IL4 IL1B
43
MAPK Pathway 70
Show member pathways
 12.14 TLR2 TLR1 PIK3C2A IL1B
44
Amoebiasis 36
12.12 TNF TLR2 IL6 IL1B IL10 IFNG
45
IL12-mediated signaling events 1
Show member pathways
 12.1 IL4 IL1B IL18 IFNG
46
AGE-RAGE signaling pathway in diabetic complications 36
12.1 TNF IL6 IL1B CXCL8 CCL2
47
TNF signaling pathway 36
12.09 TNF IL6 IL1B CCL2
48
Spinal Cord Injury 1
12.09 TNF IL6 IL4 IL1B IFNG CXCL8
49
Senescence and Autophagy in Cancer 1
12.06 IL6 IL1B IFNG CXCL8
50
NF-kappa B signaling pathway 36
12.04 TNF IL1B CXCL8 CD40LG
Sources

GO Terms for Leptospirosis

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Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.8 SLC9A3 SLC12A1 LCN2 IL6 F2 CCL2
2 extracellular region GO:0005576 9.8 TNF PTX3 LCN2 IL6 IL4 IL1B
3 extracellular space GO:0005615 9.47 TNF PTX3 LCN2 IL6 IL4 IL1B
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR2 TLR1

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR2 TLR1 IL6 IL4 IL1B IL18
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TLR2 IL6 IL4 IL1B IL18
3 negative regulation of cell proliferation GO:0008285 10.13 TLR2 IL6 IL1B IL10 CXCL8
4 positive regulation of protein phosphorylation GO:0001934 10.02 TNF IL1B IFNG F2
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.99 TNF IL6 IL1B IL10
6 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 IL6 CRP
7 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR2 IL1B IL18
8 B cell differentiation GO:0030183 9.92 IL4 IL10 CD40LG
9 cellular response to organic cyclic compound GO:0071407 9.92 TNF IL1B IL18 CCL2
10 cellular response to hydrogen peroxide GO:0070301 9.91 LCN2 IL6 AQP1
11 regulation of insulin secretion GO:0050796 9.91 TNF IL1B IFNG
12 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10
13 positive regulation of T cell proliferation GO:0042102 9.91 IL6 IL4 IL1B CD40LG
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF TLR2 IL6 IL1B IL18 CD40LG
15 positive regulation of gene expression GO:0010628 9.91 TNF TLR2 LCN2 IL6 IL4 IL1B
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL6 IL18
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.9 TNF TLR2 IL1B IL18
18 positive regulation of interferon-gamma production GO:0032729 9.89 TNF IL1B IL18
19 positive regulation of interleukin-6 production GO:0032755 9.89 TNF TLR2 IL6 IL1B
20 humoral immune response GO:0006959 9.88 TNF IL6 IFNG CCL2
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 TNF IL6 IL4 IL18 IFNG
22 protein kinase B signaling GO:0043491 9.87 TNF IL1B CCL2
23 acute-phase response GO:0006953 9.87 IL6 F2 CRP
24 positive regulation of interleukin-6 secretion GO:2000778 9.87 TNF TLR2 IL1B
25 cellular response to lipopolysaccharide GO:0071222 9.87 TNF LCN2 IL6 IL1B IL10 CXCL8
26 microglial cell activation GO:0001774 9.86 TNF TLR2 IFNG
27 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
28 positive regulation of interleukin-8 production GO:0032757 9.85 TNF TLR2 IL1B
29 positive regulation of interleukin-12 production GO:0032735 9.85 TLR2 IFNG CD40LG
30 positive regulation of phagocytosis GO:0050766 9.85 TNF PTX3 IL1B IFNG
31 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF PTX3 IL1B IFNG
32 positive regulation of chemokine production GO:0032722 9.82 TNF TLR2 IL6
33 positive regulation of glial cell proliferation GO:0060252 9.82 TNF IL6 IL1B
34 astrocyte activation GO:0048143 9.81 TNF IL1B IFNG
35 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.81 TNF IL1B IFNG
36 positive regulation of JAK-STAT cascade GO:0046427 9.81 TNF IL6 IL10 F2
37 cytokine-mediated signaling pathway GO:0019221 9.81 TNF LCN2 IL6 IL4 IL1B IL18
38 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 TNF IL1B IL10
39 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.79 TLR2 IFNG CCL2
40 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.79 TNF TLR1 IL1B
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 TNF TLR2 IL1B IL18 CCL2
42 response to molecule of bacterial origin GO:0002237 9.76 TLR2 IL10 CXCL8
43 negative regulation of amyloid-beta clearance GO:1900222 9.74 TNF IFNG
44 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10
45 opsonization GO:0008228 9.74 PTX3 CRP
46 positive regulation of chemokine biosynthetic process GO:0045080 9.74 TNF IL1B IFNG
47 endothelial cell apoptotic process GO:0072577 9.73 TNF IL10
48 positive regulation of NMDA glutamate receptor activity GO:1904783 9.73 IFNG CCL2
49 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IL4 IL10 IFNG

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNF IL6 IL4 IL1B IL18 IL10
2 lipopeptide binding GO:0071723 9.26 TLR2 TLR1
3 growth factor activity GO:0008083 9.26 IL6 IL4 IL10 F2
4 complement component C1q binding GO:0001849 9.16 PTX3 CRP
Sources

Sources for Leptospirosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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