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MCID: LPT001
MIFTS: 64

Leptospirosis

Categories: Rare diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Leptospirosis

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MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 12 76 53 59 55 3 44 15 73
Weil Disease 53 44 73
Hemorrhagic Jaundice 53 73
Stuttgart Disease 53 73
Fort Bragg Fever 12 73
Canicola Fever 53 73
Leptospirosis Icterohaemorrhagica 12
Equine Infectious Anemia 73
Icterohemorrhagic Fever 53
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 73
Swineherd's Disease 53
Cane-Cutter Fever 53
Nanukayami Fever 12
Rice-Field Fever 53
Weil's Disease 12
Weil Syndrome 76
Swamp Fever 53
Nanukayami 73
Mud Fever 53

Characteristics:

Orphanet epidemiological data:

59
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2297
ICD10 33 A27 A27.0 A27.9
ICD9CM 35 100 100.0 100.9
NCIt 50 C84825
Orphanet 59 ORPHA509
ICD10 via Orphanet 34 A27.8 A27.9 A27.0
MESH via Orphanet 45 D007922
UMLS via Orphanet 74 C0023364
Sources

Summaries for Leptospirosis

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Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to acalculous cholecystitis and mononeuritis multiplex, and has symptoms including jaundice, chills and fever. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone and Antiemetics have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia : 76 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Sources

Related Diseases for Leptospirosis

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Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 429)
# Related Disease Score Top Affiliating Genes
1 acalculous cholecystitis 30.9 CD40LG CRP
2 mononeuritis multiplex 30.5 CD40LG CRP
3 panuveitis 30.2 CD40LG IL10 TNF
4 hepatitis a 30.1 CD40LG F2 TNF
5 melioidosis 29.9 IL10 IL6 TLR2 TNF
6 aseptic meningitis 29.9 CXCL8 IL10 IL1B TNF
7 hepatitis e 29.9 CD40LG F2 TNF
8 myocarditis 29.8 CD40LG IL6 TNF
9 crimean-congo hemorrhagic fever 29.8 IL6 PIK3C2A TNF
10 end stage renal failure 29.7 CRP IL6 TNF
11 uveitis 29.7 CCL2 IL10 TNF
12 avian influenza 29.6 CXCL8 IL6 TNF
13 acute pancreatitis 29.5 CRP CXCL8 IL10 IL6
14 respiratory failure 29.4 CRP CXCL8 PIK3C2A TNF
15 intussusception 29.4 CD40LG CRP IL6
16 transverse myelitis 29.3 CXCL8 IL10 IL6 TNF
17 q fever 29.2 CD40LG IL10 IL1B TLR2 TNF
18 acute respiratory distress syndrome 29.1 CXCL8 IL1B IL6 TNF
19 vasculitis 29.1 CCL2 CD40LG CRP TNF
20 pericarditis 29.1 CRP IL1B IL6 TNF
21 hemorrhagic fever 29.0 CD40LG F2 IL10 IL6 TNF
22 gingivitis 28.9 CXCL8 IL1B IL6 TNF
23 scrub typhus 28.8 CD40LG CRP IL10 IL1B TLR2 TNF
24 adult respiratory distress syndrome 28.8 CXCL8 F2 IL10 IL6 TNF
25 hemorrhagic fever with renal syndrome 28.8 CD40LG CRP IL10 IL6 TNF
26 toxoplasmosis 28.7 CD40LG IL10 IL1B IL6 TNF
27 brucellosis 28.6 CD40LG CRP CXCL8 IL10 IL6 TNF
28 cholangitis 28.5 CD40LG CRP F2 IL6 TNF
29 kawasaki disease 28.4 CCL2 CRP IL10 IL6 TNF
30 diabetes mellitus 28.3 CRP IL1B IL6 PIK3C2A TNF
31 central nervous system vasculitis 28.2 CD40LG CRP IL1B IL6 TNF
32 chikungunya 27.9 CCL2 CD40LG IL1B IL6 TNF
33 chlamydia 26.4 CD40LG CRP CXCL8 IL10 IL1B IL6
34 malaria 25.9 CCL2 CD40LG CRP CXCL8 IL10 IL1B
35 meningitis 25.7 CCL2 CD40LG CRP CXCL8 IL10 IL1B
36 pneumonia 24.6 CCL2 CD40LG CRP CXCL8 IL10 IL1B
37 peritonitis 24.2 AQP1 CCL2 CRP CXCL8 F2 IL10
38 dengue disease 11.3
39 punctate inner choroidopathy 11.0 IL10 TNF
40 tropical endomyocardial fibrosis 11.0 IL10 TNF
41 leri-weill dyschondrosteosis 10.9
42 moyamoya disease 1 10.9
43 microscopic polyangiitis 10.9 IL10 TNF
44 multifocal choroiditis 10.9 IL10 TNF
45 endomyocardial fibrosis 10.9 IL10 TNF
46 transient hypogammaglobulinemia 10.9 IL10 TNF
47 marburg hemorrhagic fever 10.9 F2 TNF
48 malignant otitis externa 10.8 CRP F2
49 anterior compartment syndrome 10.8 F2 PIK3C2A
50 chronic thromboembolic pulmonary hypertension 10.8 CRP F2

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis
Sources

Symptoms & Phenotypes for Leptospirosis

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Symptoms:

12
  • • jaundice
  • • chills
  • • fever
  • • muscle pain
  • • hepatomegaly

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 AQP1 TNF CD40LG CXCL8 F2 IL10
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 AQP1 TNF CD40LG CXCL8 F2 IL10
3 Decreased ionizing radiation sensitivity GR00232-A-1 9.5 PIK3C2A SLC12A1 SLC9A3 TNF CD40LG IL10

MGI Mouse Phenotypes related to Leptospirosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.26 AQP1 IL10 CD40LG IL1B CRP IL6
2 homeostasis/metabolism MP:0005376 10.21 AQP1 IL10 CD40LG IL1B CRP IL6
3 hematopoietic system MP:0005397 10.16 AQP1 IL10 CD40LG IL1B IL6 F2
4 immune system MP:0005387 10.14 IL10 CCL2 CD40LG IL1B CRP IL6
5 mortality/aging MP:0010768 10.02 F2 AQP1 IL10 CD40LG IL1B IL6
6 integument MP:0010771 9.97 F2 IL10 CD40LG IL1B IL6 TLR2
7 nervous system MP:0003631 9.91 F2 AQP1 IL10 CD40LG IL1B IL6
8 renal/urinary system MP:0005367 9.7 AQP1 CD40LG IL6 SLC9A3 TLR2 PIK3C2A
9 reproductive system MP:0005389 9.56 F2 AQP1 IL10 CD40LG IL6 SLC9A3
10 skeleton MP:0005390 9.28 AQP1 IL10 CD40LG IL1B IL6 F2
Sources

Drugs & Therapeutics for Leptospirosis

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Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
2 Antiemetics Phase 2, Phase 3
3 Anti-Inflammatory Agents Phase 2, Phase 3
4 Antineoplastic Agents, Hormonal Phase 2, Phase 3
5 Arginine Vasopressin Phase 2, Phase 3
6 Autonomic Agents Phase 2, Phase 3
7 BB 1101 Phase 2, Phase 3
8 Coagulants Phase 2, Phase 3
9 Deamino Arginine Vasopressin Phase 2, Phase 3
10 Dexamethasone acetate Phase 2, Phase 3 1177-87-3
11 Gastrointestinal Agents Phase 2, Phase 3
12 glucocorticoids Phase 2, Phase 3
13 Hemostatics Phase 2, Phase 3
14 HIV Protease Inhibitors Phase 2, Phase 3
15 Hormone Antagonists Phase 2, Phase 3
16 Hormones Phase 2, Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
18 Natriuretic Agents Phase 2, Phase 3
19 Peripheral Nervous System Agents Phase 2, Phase 3
20
protease inhibitors Phase 2, Phase 3
21 Vasopressins Phase 2, Phase 3
22 arginine Nutraceutical Phase 2, Phase 3
23
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
24
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
25
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
26
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
27
Dimenhydrinate Approved Not Applicable 523-87-5 441281
28
Ethanol Approved 64-17-5 702
29
Doxycycline Approved, Investigational, Vet_approved Early Phase 1 564-25-0 54671203
30
Tetracycline Approved, Vet_approved Early Phase 1 60-54-8 5353990
31 Sugarcane Approved, Nutraceutical Not Applicable
32 tannic acid Approved, Nutraceutical Not Applicable
33 Antibodies Not Applicable
34 Immunoglobulins Not Applicable
35 Anti-Bacterial Agents ,Not Applicable,Early Phase 1
36 Antibiotics, Antitubercular ,Not Applicable
37 Anti-Infective Agents ,Not Applicable,Early Phase 1
38 Antitubercular Agents Not Applicable
39 Antimalarials Early Phase 1
40 Antiparasitic Agents Early Phase 1
41 Antiprotozoal Agents Early Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
2 Seroprevalence Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Completed NCT03497572
3 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
4 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
5 CKDu in Sugarcane Workers in Guatemala Completed NCT03049527 Not Applicable
6 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Recruiting NCT02000635
7 Scrub Typhus RDT Study Recruiting NCT03269266
8 The Impact of C-reactive Protein Testing Recruiting NCT02758821 Not Applicable
9 French West Indies Leptospirosis Study Active, not recruiting NCT01607047
10 Immune Response After Leptospirosis Infection Not yet recruiting NCT02898519
11 Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men Not yet recruiting NCT02864550 Early Phase 1 Doxycycline

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

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Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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MalaCards organs/tissues related to Leptospirosis:

41
Kidney, Testes, Lung, T Cells, Heart, Eye, Liver
Sources

Publications for Leptospirosis

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Articles related to Leptospirosis:

(show top 50) (show all 766)
# Title Authors Year
1
Socio-epidemiological characterization of human leptospirosis in the Federal District, Brazil, 2011-2015. ( 29972572 )
2018
2
Leptospirosis Health Intervention Module Effect on Knowledge, Attitude, Belief, and Practice among Wet Market Workers in Northeastern Malaysia: An Intervention Study. ( 29970799 )
2018
3
Chimeras could help in the fight against leptospirosis. ( 29350615 )
2018
4
Report of a case of leptospirosis: the importance of asking the patient about workplace factors. ( 29437314 )
2018
5
A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity. ( 29758037 )
2018
6
Leptospirosis presenting as haemolytic uraemic syndrome: a case report. ( 29378539 )
2018
7
Risk factors for human acute leptospirosis in northern Tanzania. ( 29879114 )
2018
8
Prevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BHV 1), Leptospirosis and Neosporosis, and associated risk factors in 161 Irish beef herds. ( 29304782 )
2018
9
Leptospirosis Pathophysiology: Into the Storm of Cytokines. ( 29974037 )
2018
10
Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection. ( 29452258 )
2018
11
Travel-related leptospirosis in the Netherlands 2009-2016: An epidemiological report and case series. ( 29753855 )
2018
12
Knowledge, attitude and practice about leptospirosis prevention among town service workers in northeastern Malaysia: a cross sectional study. ( 29938244 )
2018
13
Challenges in the diagnosis of leptospirosis outwith endemic settings: a Scottish single centre experience. ( 29741518 )
2018
14
Seroprevalence and risk factor analysis of human leptospirosis in distinct climatic regions of Pakistan. ( 29407239 )
2018
15
Leptospirosis in Caspian Sea littoral, Gilan Province, Iran. ( 29407848 )
2018
16
Changing trend in the seroprevalence and risk factors of human leptospirosis in the South Andaman Island, India. ( 29873192 )
2018
17
Diagnosis of Human Leptospirosis in a Clinical Setting: Real-Time PCR High Resolution Melting Analysis for Detection of Leptospira at the Onset of Disease. ( 29907838 )
2018
18
Unusual ocular clinical manifestation of leptospirosis. ( 29398239 )
2018
19
Pathology and pathogenesis of human leptospirosis: a commented review. ( 29846473 )
2018
20
High incidence of leptospirosis in an observational study of hospital outpatients in Vanuatu highlights the need for improved awareness and diagnostic capacities. ( 29864127 )
2018
21
Evaluation of a novel outer membrane surface-exposed protein, LIC13341 of Leptospira, as an adhesin and serodiagnostic candidate marker for leptospirosis. ( 29969088 )
2018
22
Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China. ( 29866175 )
2018
23
Factors associated with severity and mortality in patients with confirmed leptospirosis at a regional hospital in northern Taiwan. ( 29934034 )
2018
24
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. ( 29332210 )
2018
25
Leptospirosis in Coastal South India: A Facility Based Study. ( 29862254 )
2018
26
Knowledge, attitudes and practices (KAP) regarding leptospirosis among residents of riverside settlements of Santa Fe, Argentina. ( 29734328 )
2018
27
Leptospiral 3-hydroxyacyl-CoA dehydrogenase as an early urinary biomarker of leptospirosis. ( 29862373 )
2018
28
Leptospirosis among Returned Travelers: A GeoSentinel Site Survey and Multicenter Analysis-1997-2016. ( 29761761 )
2018
29
ERRATUM: Pathology and pathogenesis of human leptospirosis: a commented review. ( 29972465 )
2018
30
Major epidemiological factors associated with leptospirosis in Malaysia. ( 29217379 )
2018
31
Leptospirosis presenting as acute acalculous cholecystitis. ( 29152269 )
2017
32
Human leptospirosis in Seychelles: A prospective study confirms the heavy burden of the disease but suggests that rats are not the main reservoir. ( 28846678 )
2017
33
Reproductive Disorders and Leptospirosis: A Case Study in a Mixed-Species Farm (Cattle and Swine). ( 29194353 )
2017
34
Epidemiological and clinical features of leptospirosis in a highly endemic area over three time periods. ( 28857412 )
2017
35
Correction: Underestimation of Leptospirosis Incidence in the French West Indies. ( 29211733 )
2017
36
IgM ELISA for leptospirosis diagnosis: a systematic review and meta-analysis. ( 29267717 )
2017
37
Human leptospirosis in the Federal District, Brazil, 2011-2015: eco-epidemiological characterization. ( 29340454 )
2017
38
Severe leptospirosis in Morocco: comparative data from the Amazonian area. ( 28875288 )
2017
39
Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal. ( 28923024 )
2017
40
Leptospirosis in three workers on a dairy farm with unvaccinated cattle. ( 28934773 )
2017
41
Comparing antibiotic treatment for leptospirosis using network meta-analysis: a tutorial. ( 28056834 )
2017
42
Leptospirosis Cases in the Tokyo Metropolitan Area, Japan. ( 28890513 )
2017
43
Bovine leptospirosis in urban and peri-urban dairy farming in low-income countries: a "One Health" issue? ( 29233193 )
2017
44
Cardiac Magnetic Resonance of Myocardial Involvement in Leptospirosis. ( 29326780 )
2017
45
Varied presentations of leptospirosis: experience from a tertiary care hospital in north India. ( 28092222 )
2017
46
A Case of Leptospirosis-Associated Severe Pulmonary Hemorrhagic Syndrome Successfully Treated with Venovenous Extracorporeal Membrane Oxygenation. ( 29312788 )
2017
47
Leptospirosis on captive wild animals in Latin America. ( 28804053 )
2017
48
New trends in human and animal leptospirosis in Croatia, 2009-2014. ( 28063871 )
2017
49
Low-dose norfloxacin and ciprofloxacin therapy worsen leptospirosis in hamster. ( 27894961 )
2017
50
Correction: Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. ( 28950012 )
2017
Sources

Variations for Leptospirosis

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Expression for Leptospirosis

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Search GEO for disease gene expression data for Leptospirosis.
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Pathways for Leptospirosis

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Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.98 CCL2 CD40LG CRP CXCL8 IL10 IL1B
2
PEDF Induced Signaling 64
Show member pathways
 13.65 CCL2 CD40LG CXCL8 F2 IL10 IL1B
3
TGF-Beta Pathway 64
Show member pathways
 13.49 CCL2 CXCL8 F2 IL10 IL1B IL6
4
Akt Signaling 64
Show member pathways
 13.41 CCL2 CD40LG CXCL8 IL10 IL1B IL6
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.36 CCL2 CD40LG CXCL8 IL10 IL1B IL6
6
PAK Pathway 64
Show member pathways
 13.3 CCL2 CD40LG CXCL8 IL10 IL1B IL6
7
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.02 CCL2 CXCL8 IL10 IL1B IL6 TLR2
8
Allograft rejection 1 37
Show member pathways
 12.89 CD40LG CXCL8 IL10 IL1B IL6 TNF
9
Influenza A 37
Show member pathways
 12.82 CCL2 CXCL8 IL1B IL6 TLR2 TNF
10
NF-KappaB Family Pathway 64
Show member pathways
 12.72 CD40LG IL1B IL6 TLR2 TNF
11
Regulation of IFNA signaling 66
Show member pathways
 12.67 CXCL8 IL10 IL1B IL6 TNF
12
Immune response IL-23 signaling pathway 22
Show member pathways
 12.61 CCL2 F2 IL10 IL1B IL6 TNF
13
NF-kappaB Signaling 4
12.59 CCL2 CD40LG IL10 IL1B TLR2 TNF
14
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.54 CXCL8 IL6 TLR2 TNF
15
TRAF Pathway 64
Show member pathways
 12.53 CD40LG IL1B TLR2 TNF
16
Th17 cell differentiation 37
Show member pathways
 12.49 IL10 IL1B IL6 TLR2 TNF
17
T cell receptor signaling pathway 37
Show member pathways
 12.46 CD40LG IL10 IL1B IL6 TNF
18
Folate Metabolism 1
Show member pathways
 12.36 CCL2 CRP F2 IL1B IL6 TNF
19
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 CCL2 CXCL8 IL1B IL6 TLR2 TNF
20
Th1 Differentiation Pathway 65
Show member pathways
 12.31 IL10 IL1B IL6 TLR2 TNF
21
Toxoplasmosis 37
Show member pathways
 12.3 CD40LG IL10 IL1B TLR2 TNF
22
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.29 CXCL8 IL6 TLR2 TNF
23
Toll Comparative Pathway 64
Show member pathways
 12.29 CXCL8 IL1B IL6 TNF
24
Tuberculosis 37
12.27 IL10 IL1B IL6 TLR2 TNF
25
IL-1 Family Signaling Pathways 65
Show member pathways
 12.26 CXCL8 IL1B IL6 TLR2 TNF
26
C-type lectin receptor signaling pathway 37
Show member pathways
 12.24 IL10 IL1B IL6 TNF
27
Bacterial infections in CF airways 22
Show member pathways
 12.23 CXCL8 IL1B IL6 TLR2 TNF
28
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.17 CXCL8 IL10 IL1B IL6 SLC9A3 TNF
29
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.1 CCL2 CXCL8 IL10 IL1B IL6
30
MAPK Pathway 72
Show member pathways
 12 IL1B PIK3C2A TLR2
31
TNF signaling pathway 37
12 CCL2 IL1B IL6 TNF
32
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.97 IL10 IL6 TNF
33
AGE-RAGE signaling pathway in diabetic complications 37
11.95 CCL2 CXCL8 IL1B IL6 TNF
34
NF-kappa B signaling pathway 37
11.93 CD40LG CXCL8 IL1B TNF
35
Senescence and Autophagy in Cancer 1
11.92 CXCL8 IL1B IL6
36
Spinal Cord Injury 1
11.92 AQP1 CCL2 CXCL8 IL1B IL6 TNF
37
Hematopoietic cell lineage 37
11.88 IL1B IL6 TNF
38
Interleukin-4 and 13 signaling 66
11.86 CCL2 CXCL8 IL10 IL1B IL6 TNF
39
Salmonella infection (KEGG) 37
11.83 CXCL8 IL1B IL6
40
Dendritic Cells Developmental Lineage Pathway 65
11.81 IL10 IL1B IL6 TNF
41
Innate Lymphoid Cell Differentiation Pathways 65
11.79 IL10 IL1B TNF
42
Pertussis 37
11.79 CXCL8 IL10 IL1B IL6 TNF
43
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 CD40LG CXCL8 TNF
44
Amoebiasis 37
11.72 CXCL8 IL10 IL1B IL6 TLR2 TNF
45
Lung fibrosis 1
11.65 CCL2 CXCL8 IL1B IL6 TNF
46
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.63 CD40LG CXCL8 IL1B IL6 TNF
47
Rheumatoid arthritis 37
11.59 CCL2 CXCL8 IL1B IL6 TLR2 TNF
48
MSP-RON Signaling 64
11.57 CCL2 IL1B TLR2 TNF
49
Legionellosis 37
11.54 CXCL8 IL1B IL6 TLR2 TNF
50
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.52 IL1B IL6 TNF
Sources

GO Terms for Leptospirosis

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Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL2 CD40LG CRP CXCL8 F2 IL10
2 extracellular space GO:0005615 9.28 CCL2 CD40LG CRP CXCL8 F2 IL10

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 CRP IL1B IL6 TLR2 TNF
2 response to lipopolysaccharide GO:0032496 9.92 CXCL8 IL10 IL1B TLR2
3 cytokine-mediated signaling pathway GO:0019221 9.88 CCL2 CXCL8 IL10 IL1B IL6 TNF
4 platelet activation GO:0030168 9.86 CD40LG F2 IL6
5 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 IL1B TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.84 IL10 IL1B IL6 TNF
7 neutrophil chemotaxis GO:0030593 9.83 CCL2 CXCL8 IL1B
8 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TLR2 TNF
9 response to glucocorticoid GO:0051384 9.82 IL10 IL6 TNF
10 positive regulation of T cell proliferation GO:0042102 9.82 CD40LG IL1B IL6
11 humoral immune response GO:0006959 9.81 CCL2 IL6 TNF
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 IL1B TLR2 TNF
13 protein kinase B signaling GO:0043491 9.77 CCL2 IL1B TNF
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.77 CD40LG IL1B IL6 TLR2 TNF
15 positive regulation of interleukin-6 production GO:0032755 9.76 IL1B IL6 TLR2 TNF
16 immune response GO:0006955 9.76 CCL2 CD40LG CXCL8 IL10 IL1B IL6
17 acute-phase response GO:0006953 9.73 CRP F2 IL6
18 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TLR2 TNF
19 cellular response to lipopolysaccharide GO:0071222 9.72 CCL2 CXCL8 IL10 IL6 TNF
20 embryonic digestive tract development GO:0048566 9.69 CXCL8 TNF
21 cell volume homeostasis GO:0006884 9.69 AQP1 SLC12A1
22 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
23 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR2 TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
25 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 CCL2 TLR2
26 negative regulation of growth of symbiont in host GO:0044130 9.68 IL10 TNF
27 cellular homeostasis GO:0019725 9.67 AQP1 CCL2
28 PERK-mediated unfolded protein response GO:0036499 9.67 CCL2 CXCL8
29 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 IL10 TLR2
30 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
31 endothelial cell apoptotic process GO:0072577 9.66 IL10 TNF
32 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
35 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
36 regulation of immunoglobulin secretion GO:0051023 9.62 CD40LG TNF
37 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
38 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
39 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
41 lipopolysaccharide-mediated signaling pathway GO:0031663 9.56 CCL2 IL1B TLR2 TNF
42 regulation of signaling receptor activity GO:0010469 9.56 CCL2 CD40LG CXCL8 F2 IL10 IL1B
43 inflammatory response GO:0006954 9.28 CCL2 CD40LG CRP CXCL8 IL10 IL1B
44 negative regulation of cell proliferation GO:0008285 10.01 CXCL8 IL10 IL1B IL6 TLR2

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL2 CD40LG CXCL8 IL10 IL1B IL6
Sources

Sources for Leptospirosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
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35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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