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Leptospirosis

Categories: Infectious diseases, Rare diseases
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Aliases & Classifications for Leptospirosis

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MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 11 19 58 75 53 2 43 14 16 71 31 33
Fort Bragg Fever 11 71 33
Weil Disease 19 43 71
Leptospirosis Icterohaemorrhagica 11 31
Hemorrhagic Jaundice 19 71
Stuttgart Disease 19 71
Nanukayami Fever 11 33
Canicola Fever 19 71
Swamp Fever 19 33
Mud Fever 19 33
Leptospira Interrogans Autumnalis Infection 33
Leptospira Interrogans Hebdomadis Infection 33
Leptospira Interrogans Canicola Infection 33
Leptospira Interrogans Pomona Infection 33
Fever Due to Leptospira Autumnalis 33
Eia - [equine Infectious Anaemia] 33
Leptospira Interrogans Infection 33
Equine Infectious Anemia 71
Icterohemorrhagic Fever 19
Leptospirosis Canicola 33
Rat Catcher's Yellows 11
Spirochetal Jaundice 11
Canine Leptospirosis 71
Swineherd's Disease 19
Nanukayami Disease 33
Cane-Cutter Fever 19
Rice-Field Fever 19
Pretibial Fever 33
Seven-Day Fever 33
Weil's Disease 11
Weil Syndrome 75
Nanukayami 71
Gikiyami 33

Characteristics:


Prevelance:

1-9/1000000 (Europe, France, Austria, Belgium, Bulgaria, Czech Republic, Denmark, Estonia, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Malta, Netherlands, Portugal, Romania, Slovakia, Slovenia, United Kingdom) 1-9/100000 (Croatia) <1/1000000 (Finland, Luxembourg, Sweden) 58

Age Of Onset:

All ages 58

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 31 32
ICD11: 33
Orphanet: 58  
Rare infectious diseases


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Summaries for Leptospirosis

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CDC: 2 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all. Without treatment, Leptospirosis can lead to kidney damage, meningitis (inflammation of the membrane around the brain and spinal cord), liver failure, respiratory distress, and even death.

MalaCards based summary: Leptospirosis, also known as fort bragg fever, is related to dengue disease and adult respiratory distress syndrome. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Amoxicillin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and liver, and related phenotypes are nausea and vomiting and hypotension

Disease Ontology: 11 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

GARD: 19 Leptospirosis is an anthropozoonosis caused by spiral-shaped bacteria belonging to the genus Leptospira. Leptospirosis is a widespread zoonosis with a worldwide distribution and has emerged as a major public health problem in developing countries in South-East Asia and South America.

Orphanet: 58 Leptospirosis is an anthropozoonosis caused by spiral-shaped bacteria belonging to the genus Leptospira. Leptospirosis is a widespread zoonosis with a worldwide distribution and has emerged as a major public health problem in developing countries in South-East Asia and South America.

Wikipedia: 75 Leptospirosis is a blood infection caused by the bacteria Leptospira. Signs and symptoms can range from... more...
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Related Diseases for Leptospirosis

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Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1076)
# Related Disease Score Top Affiliating Genes
1 dengue disease 31.2 TNF PIK3C2A IL6 IL10 CXCL8
2 adult respiratory distress syndrome 31.1 TNF IL6 IL1B IL10 CXCL8 CRP
3 syphilis 31.0 TNF TLR2 CRP
4 interstitial nephritis 31.0 TNF LCN2 CRP
5 aseptic meningitis 30.8 TNF IL6 IL1B IL10 CXCL8 CRP
6 pancreatitis 30.8 TNF IL6 IL1B IL10 CXCL8 CRP
7 bell's palsy 30.7 TNF IL6 CRP
8 facial paralysis 30.7 TNF IL6 CRP
9 acalculous cholecystitis 30.7 F2 CRP
10 meningoencephalitis 30.6 TNF IL6 IL1B IL10 CRP
11 tularemia 30.6 TNF TLR2 IL6 IL1B
12 viral hepatitis 30.5 TLR2 IL6 IL4 IFNG F2 CRP
13 acute kidney failure 30.5 SLC9A3 PIK3C2A LCN2 IL6 IL18 F2
14 anuria 30.5 PIK3C2A LCN2 F2 CRP
15 typhoid fever 30.5 TNF IL6 IL1B IL1A IFNG F2
16 bilirubin metabolic disorder 30.5 TNF IL6 IL2 IL1B IL10 F2
17 alcohol use disorder 30.4 TNF IL6 IL1B F2 CRP
18 myelitis 30.4 TNF IL6 IL10 CXCL8
19 uremia 30.4 TNF IL6 IL1B CRP
20 lymphopenia 30.4 IL6 IL4 IL2 IL10 IFNG
21 transverse myelitis 30.4 TNF IL6 CRP
22 hantavirus hemorrhagic fever with renal syndrome 30.4 TNF IL6 CXCL8 CRP
23 chronic kidney disease 30.3 TNF LCN2 IL6 IL1B CRP
24 encephalitis 30.3 TNF TLR2 IL6 IL1B IL10 CXCL8
25 disseminated intravascular coagulation 30.3 TNF PIK3C2A IL6 IL10 F2 CRP
26 viral encephalitis 30.3 TNF IL6 IL1B IL10 CCL2
27 pericarditis 30.3 TNF IL6 IL1B IFNG CXCL8 CRP
28 posterior uveitis 30.3 TNF IL6 IL2
29 headache 30.3 TNF IL2 CXCL8
30 poliomyelitis 30.3 TNF IL6 IL2 IL10 IFNG
31 hepatitis a 30.2 TNF IL4 IL1B IL10 IFNG F2
32 blastomycosis 30.2 TNF IL6 CRP
33 choroiditis 30.2 TNF IL10 IFNG CRP
34 iridocyclitis 30.2 TNF IL6 IL1B IL10 CXCL8 CRP
35 echinococcosis 30.2 TNF TLR2 IL6 IL10 IFNG
36 optic neuritis 30.2 TNF IL6 IL1B IL10 CXCL8
37 deficiency anemia 30.2 TNF IL6 IL2 IL1B IL10 F2
38 hepatitis e 30.2 TNF IL10 IFNG F2
39 spondyloarthropathy 1 30.2 TNF IL6 IL1B IL10 CRP
40 severe cutaneous adverse reaction 30.2 TNF IL6 IFNG CRP
41 panuveitis 30.2 TNF IL6 IL1B IL10 IFNG CRP
42 lymphocytic choriomeningitis 30.2 TLR2 IL6 CXCL8
43 anemia, autoimmune hemolytic 30.2 IL6 IL2 IL10 CRP
44 cavernous sinus thrombosis 30.2 F2 CRP
45 dengue hemorrhagic fever 30.1 TNF IL6 IL10 CXCL8
46 hypopyon 30.1 TNF IL6 IL1B IL10 CRP
47 acute myocarditis 30.1 TNF IL6 IL1B IL10 CRP
48 liver disease 30.1 TNF IL6 IL1A IL18 F2 CCL2
49 pancytopenia 30.1 IL6 IFNG F2 CRP
50 conjunctivitis 30.1 TNF IL6 IL4 IL2 IL10 IFNG

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Disease Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis
Sources

Symptoms & Phenotypes for Leptospirosis

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Human phenotypes related to Leptospirosis:

58 30 (show all 40)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002017
2 hypotension 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002615
3 fever 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001945
4 thrombocytopenia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0001873
5 abdominal pain 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002027
6 anorexia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002039
7 arthralgia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002829
8 myalgia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0003326
9 headache 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002315
10 hyperproteinemia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0002152
11 conjunctival hyperemia 58 30 Frequent (33%) Frequent (79-30%)
 HP:0030953
12 elevated serum transaminases during infections 58 30 Frequent (33%) Frequent (79-30%)
 HP:0008150
13 hepatomegaly 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002240
14 hepatitis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0012115
15 hemoptysis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002105
16 jaundice 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000952
17 cough 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0012735
18 skin rash 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0000988
19 meningitis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001287
20 respiratory distress 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002098
21 pleural effusion 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002202
22 diarrhea 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002014
23 lymphadenopathy 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0002716
24 first degree atrioventricular block 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0011705
25 acute kidney injury 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0001919
26 pharyngitis 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0025439
27 chills 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0025143
28 pulmonary hemorrhage 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0040223
29 cellular urinary casts 58 30 Occasional (7.5%) Occasional (29-5%)
 HP:0031197
30 arrhythmia 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0011675
31 uveitis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000554
32 pericarditis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0001701
33 retinal hemorrhage 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0000573
34 optic neuritis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0100653
35 subconjunctival hemorrhage 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0011896
36 papilledema 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0001085
37 chorioretinitis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0012424
38 rhabdomyolysis 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0003201
39 macular cotton wool spot 58 30 Very rare (1%) Very rare (<4-1%)
 HP:0030497
40 morphological abnormality of the central nervous system 58 Occasional (29-5%)

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.15 AQP1 CCL2 CRP CXCL8 F2 IFNG
2 no effect GR00402-S-2 10.15 CCL2 CRP F2 IFNG IL10 IL18
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 10.13 CXCL8 IL10 IL18 IL1A IL1B LCN2
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 10.13 AQP1 CXCL8 IL10 IL18 IL1B IL2

MGI Mouse Phenotypes related to Leptospirosis:

45 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.49 AQP1 CCL2 CRP F2 IFNG IL10
2 growth/size/body region MP:0005378 10.4 AQP1 CCL2 F2 IFNG IL10 IL18
3 cardiovascular system MP:0005385 10.39 AQP1 CCL2 CRP F2 IFNG IL10
4 immune system MP:0005387 10.38 AQP1 CCL2 CRP F2 IFNG IL10
5 behavior/neurological MP:0005386 10.28 AQP1 CCL2 F2 IFNG IL10 IL18
6 cellular MP:0005384 10.26 CCL2 F2 IFNG IL10 IL18 IL2
7 endocrine/exocrine gland MP:0005379 10.25 AQP1 F2 IFNG IL10 IL2 IL4
8 neoplasm MP:0002006 10.24 CCL2 IFNG IL10 IL1A IL1B IL2
9 digestive/alimentary MP:0005381 10.24 CCL2 F2 IFNG IL10 IL18 IL2
10 renal/urinary system MP:0005367 10.23 AQP1 IFNG IL4 IL6 LCN2 PIK3C2A
11 liver/biliary system MP:0005370 10.21 CCL2 IFNG IL10 IL2 IL4 IL6
12 adipose tissue MP:0005375 10.2 AQP1 CCL2 F2 IL18 IL6 LCN2
13 muscle MP:0005369 10.17 CCL2 F2 IFNG IL10 IL18 IL6
14 hematopoietic system MP:0005397 10.11 AQP1 CCL2 F2 IFNG IL10 IL18
15 reproductive system MP:0005389 10.1 AQP1 CCL2 F2 IFNG IL10 IL2
16 respiratory system MP:0005388 10.02 AQP1 F2 IFNG IL10 IL2 IL4
17 skeleton MP:0005390 10 AQP1 CCL2 F2 IFNG IL10 IL1B
18 mortality/aging MP:0010768 9.83 AQP1 CCL2 F2 IFNG IL10 IL18
19 integument MP:0010771 9.4 CCL2 F2 IFNG IL10 IL18 IL1A
Sources

Drugs & Therapeutics for Leptospirosis

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Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3 Antibiotics, Antitubercular Phase 4
4 Anti-Bacterial Agents Phase 4
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3 3680
6
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 3003 5743
7
Arginine Approved, Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322
8 Antineoplastic Agents, Hormonal Phase 2, Phase 3
9 Hormones Phase 2, Phase 3
10 Arginine Vasopressin Phase 2, Phase 3
11 Hormone Antagonists Phase 2, Phase 3
12 Vasopressins Phase 2, Phase 3
13 Antiemetics Phase 2, Phase 3
14 glucocorticoids Phase 2, Phase 3
15 Anti-Inflammatory Agents Phase 2, Phase 3
16 Gastrointestinal Agents Phase 2, Phase 3
17 Hemostatics Phase 2, Phase 3
18 Deamino Arginine Vasopressin Phase 2, Phase 3
19 Coagulants Phase 2, Phase 3
20
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 9812710 6427057
21
Albendazole Approved, Vet_approved 54965-21-8 2082
22
Mebendazole Approved, Vet_approved 31431-39-7 4030
23 Immunologic Factors
24 Immunoglobulins, Intravenous
25 Immunoglobulin G
26 Vaccines
27 Immunoglobulins
28 Immunoglobulin M
29 Antibodies

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Open-label Non-inferiority Trial, Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte) Not yet recruiting NCT04211649 Phase 4 3 days of antibiotherapy
2 An Open Randomized Controlled Trial of Desmopressin, and Dexamethasone as Adjunctive Therapy in Patients With Pulmonary Hemorrhage Associated With Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
3 Utility of Quantitative Polymerase Chain Reaction to Predict Clinical Outcome of Leptospirosis in French West Indies Unknown status NCT01607047
4 Serological Response in Patients Infected by Leptospirosis 1 to 7 Years Earlier Unknown status NCT02898519
5 Severe Leptospirosis in Non-tropical Areas: a Nationwide, Multicentre, Retrospective Study in French ICUs Completed NCT03912506
6 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
7 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
8 Seroprevalence, Multi-center, Phase IV Cross-sectional Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Completed NCT03497572
9 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Recruiting NCT02000635
10 Leptospirosis Registry - LeptoScope Recruiting NCT04288674
11 Cohort of Hospitalized Patients Suspected of Leptospirosis Recruiting NCT04034550
12 Study of the Incidence of Jarisch-Herxheimer Reaction in Leptospirosis Patients in New Caledonia Recruiting NCT04882046
13 Leptospirosis, Tularaemia and Hepatitis E in a Rural Mountain Valley in the Alpine Region of Switzerland - A Cross-sectional Exploratory Seroprevalence Study Recruiting NCT05300425
14 Leptospirosis Care Bundle Study: A Randomized Controlled Trial Recruiting NCT05425524
15 Study of the Innate Immune Response to the Acute Phase of Human Leptospirosis - IMMUNOLEPTO Recruiting NCT05413720
16 Chronic Post-leptospirosis Manifestations in Reunion Not yet recruiting NCT05436756

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

Sources

Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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Organs/tissues related to Leptospirosis:

MalaCards : Spinal Cord, Kidney, Liver, Skin, Brain, Lung, Eye
Sources

Publications for Leptospirosis

About this section

Articles related to Leptospirosis:

(show top 50) (show all 8500)
# Title Authors PMID Year
1
Nephropathia epidemica and leptospirosis in Champagne-Ardenne, France: comparison of clinical, biological and epidemiological profiles. 53 62
19229563 2009
2
Recombinant multiepitope protein for diagnosis of leptospirosis. 53 62
18827193 2008
3
Evaluation of leptospiral recombinant antigens MPL17 and MPL21 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays. 53 62
18799647 2008
4
Leptospirosis vaccines. 53 62
18072968 2007
5
Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology. 53 62
16433137 2005
6
Leptospirosis presenting with mania and psychosis: four consecutive cases seen in a military hospital in Turkey. 53 62
16480244 2005
7
Preliminary survey of leptospirosis amongst febrile patients from urban slums of East Delhi. 53 62
12839344 2003
8
Evaluation of the clinical utility of a rapid blood test for human leptospirosis. 53 62
12007438 2002
9
Evaluation of recombinant Leptospira antigen-based enzyme-linked immunosorbent assays for the serodiagnosis of leptospirosis. 53 62
11526167 2001
10
Lateral-flow assay for rapid serodiagnosis of human leptospirosis. 53 62
11139212 2001
11
International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human serum specimens. 53 62
10449473 1999
12
Field evaluation of a one-step dipstick assay for the diagnosis of human leptospirosis in the Seychelles. 53 62
10203172 1999
13
Macroscopic agglutination test for rapid diagnosis of human leptospirosis. 53 62
9774553 1998
14
Evaluation of the indirect hemagglutination assay for diagnosis of acute leptospirosis. 53 62
9431911 1998
15
Prediction of leptospirosis outbreaks by hydroclimatic covariates: a comparative study of statistical models. 62
36306013 2022
16
Leptospira spp. strains associated with Bovine Genital Leptospirosis (BGL). 62
36309182 2022
17
Anti-macrophage migration inhibitory factor (MIF) activity of ibudilast: A repurposing drug attenuates the pathophysiology of leptospirosis. 62
36150555 2022
18
Urban flooding and risk of leptospirosis; Pakistan on the verge of a new disaster: A call for action. 62
36463767 2022
19
Leptospirosis: Prognostic Model for Patient Mortality in the Transcarpathian Region, Ukraine. 62
36445174 2022
20
[Infection outbreak among German and Finish troups in Eastern Lapland during World War II - First description of hantavirus disease in the German language area]. 62
35732176 2022
21
Leptospiral sphingomyelinase Sph2 as a potential biomarker for diagnosis of leptospirosis. 62
36375539 2022
22
One health approach on serosurvey of anti-Leptospira spp. in homeless persons and their dogs in South Brazil. 62
36277102 2022
23
Leptospira interrogans in bats in Rio Grande do Sul State, Brazil: epidemiologic aspects and phylogeny. 62
36205841 2022
24
Proteomic dataset comparing strains of Leptospira borgpetersenii serovar Hardjo cultured at different temperatures. 62
36425979 2022
25
Prevalence of anti-leptospiral IgM and detection of pathogenic Leptospira species DNA in neonates presenting with clinical sepsis in Southwestern Uganda. 62
36461021 2022
26
Leptospiral lipopolysaccharide mediated Hog1 phosphorylation in Saccharomyces cerevisiae directs activation of autophagy. 62
36273740 2022
27
Streptomycin treatment of genital carriers of Leptospira in experimentally infected sheep on different estrous phases. 62
36201904 2022
28
Isolation of a novel DNA Aptamer against LipL32 as a potential diagnostic agent for the detection of pathogenic Leptospira. 62
36426669 2022
29
Development and evaluation of polyclonal antibody-based antigen detection ELISA and dot blot assays as a less costly diagnostic alternative for pathogenic leptospira infection. 62
36455637 2022
30
Cellular and humoral immune responsiveness to inactivated Leptospira interrogans in dogs vaccinated with a tetravalent Leptospira vaccine. 62
36411135 2022
31
Detection of Leptospira spp. in genitourinary tract of female goats managed in the brazilian semiarid. 62
36116606 2022
32
Culture-Independent Detection and Identification of Leptospira Serovars. 62
36445143 2022
33
Risk factors associated with Leptospira sp. seroprevalence in goats in Northeast of Brazil. 62
36063662 2022
34
Prevalence of Pathogenic Leptospira spp. in Non-Volant Small Mammals of Hutan Lipur Sekayu, Terengganu, Malaysia. 62
36365051 2022
35
Leptospirosis and COVID-19 co-infection case in Bangladesh. 62
36451748 2022
36
Ocular leptospirosis: lack of awareness among ophthalmologists and challenges in diagnosis. 62
36206109 2022
37
Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru. 62
36162442 2022
38
An Overview of Anthropogenic Actions as Drivers for Emerging and Re-Emerging Zoonotic Diseases. 62
36422627 2022
39
Potential Drivers for the Re-Emergence of Canine Leptospirosis in the United States and Canada. 62
36422928 2022
40
Gut microbiota status in leptospirosis: An unrecognized player? 62
36385749 2022
41
A New Recombinant Multiepitope Chimeric Protein of Leptospira interrogans Is a Promising Marker for the Serodiagnosis of Leptospirosis. 62
36355904 2022
42
Undetected serovars: leptospirosis cases in the Cairns region during the 2021 wet season. 62
36384433 2022
43
One Health: An Effective and Ethical Approach to Leptospirosis Control in Australia. 62
36422940 2022
44
Spatio-temporal analysis of leptospirosis in Brazil and its relationship with flooding. 62
36468592 2022
45
Seroprevalence, distribution, and risk factors for human leptospirosis in the United States Virgin Islands. 62
36378681 2022
46
Evaluating immunochromatographic test kits for diagnosis of acute human leptospirosis: A systematic review. 62
36458294 2022
47
Leptospirosis: A Rare Cause of Hyperbilirubinemia and Acute Kidney Injury in a Non-endemic Area. 62
36465219 2022
48
[Leptospirosis: A growing health threat to fish farming and recreational activities]. 62
35483416 2022
49
Re-emerging zoonotic disease Leptospirosis in Tanzania amid the ongoing COVID-19 pandemic: Needs attention - Correspondence. 62
36351526 2022
50
Leptospirosis: Epidemiological and Clinical Characteristics at the National Reference Hospital in Panama. 62
36375451 2022
Sources

Variations for Leptospirosis

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Expression for Leptospirosis

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Search GEO for disease gene expression data for Leptospirosis.
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Pathways for Leptospirosis

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Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.09 TNF TLR2 TLR1 LCN2 IL6 IL4
2
ERK Signaling 64
Show member pathways
 13.92 TNF IL6 IL4 IL2 IL1B IL1A
3
MIF Mediated Glucocorticoid Regulation 64
Show member pathways
 13.78 TNF IL6 IL4 IL2 IL1B IL1A
4
TGF-Beta Pathway 64
Show member pathways
 13.69 TNF IL6 IL4 IL2 IL1B IL1A
5
Prolactin Signaling 64
Show member pathways
 13.61 TNF TLR2 TLR1 PIK3C2A IL6 IL4
6
Akt Signaling 64
Show member pathways
 13.57 CCL2 CXCL8 IL10 IL18 IL1A IL1B
7
PAK Pathway 64
Show member pathways
 13.46 TNF IL6 IL4 IL2 IL1B IL1A
8
Cytokine Signaling in Immune system 66
Show member pathways
 13.46 CCL2 CXCL8 IFNG IL10 IL18 IL1A
9
Toll-like receptor signaling pathway 74
Show member pathways
 13.03 TNF TLR2 TLR1 IL6 IL2 IL1B
10
NF-KappaB Family Pathway 64
Show member pathways
 12.88 TNF TLR2 TLR1 IL6 IL2 IL1B
11
Nuclear receptors meta-pathway 74
Show member pathways
 12.82 TNF IL2 IL1B IFNG CCL2
12
IL-1 Family Signaling Pathways 65
Show member pathways
 12.81 CXCL8 IL18 IL1A IL1B IL6 TLR2
13
Overview of interferons-mediated signaling pathway 74
Show member pathways
 12.8 TNF IL6 IL4 IL2 IL1B IL1A
14
Immune response IL-23 signaling pathway 22
Show member pathways
 12.76 CCL2 F2 IFNG IL10 IL18 IL1B
15
NF-kappaB Signaling 3
12.73 TNF TLR2 TLR1 IL4 IL2 IL1B
16
Toll-Like receptor Signaling Pathways 65
Show member pathways
 12.72 TNF TLR2 TLR1 IL6 IL1B IL18
17
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 65
Show member pathways
 12.7 TNF TLR2 TLR1 IL1B IL1A
18
Bacterial infections in CF airways 22
Show member pathways
 12.58 TNF TLR2 TLR1 IL6 IL4 IL1B
19
Toll Comparative Pathway 64
Show member pathways
 12.5 CXCL8 IFNG IL1A IL1B IL6 TNF
20
NF-kappaB Pathway 70
Show member pathways
 12.48 PIK3C2A IL2 IL1B IL1A
21
IL-17 Family Signaling Pathways 65
Show member pathways
 12.42 TNF TLR2 IL6 CXCL8 CCL2
22
Sudden infant death syndrome (SIDS) susceptibility pathways 74
12.39 TNF SLC9A3 IL6 IL1B IL1A IL10
23
Colorectal Cancer Metastasis 64
12.35 TNF TLR2 TLR1 IL6 IFNG
24
Neuroinflammation and glutamatergic signaling 74
12.32 IFNG IL10 IL1A IL1B IL4 IL6
25
T-cell activation SARS-CoV-2 74
Show member pathways
 12.31 IFNG IL10 IL2 IL4 TNF
26
Immune response CD16 signaling in NK cells 22
Show member pathways
 12.28 TNF IL4 IL2 IFNG
27
MAPK Pathway 70
Show member pathways
 12.23 TLR2 TLR1 PIK3C2A IL2 IL1B IL1A
28
Hematopoietic Stem Cells and Lineage-specific Markers 65
12.21 TNF IL6 IL4 IL2 IL10 IFNG
29
Interleukin-4 and Interleukin-13 signaling 66
12.17 CCL2 CXCL8 IL10 IL18 IL1A IL1B
30
IL12-mediated signaling events 61
Show member pathways
 12.16 IL4 IL2 IL1B IL18 IFNG
31
Spinal cord injury 74
12.16 AQP1 CCL2 CXCL8 IFNG IL1A IL1B
32
Senescence and autophagy in cancer 74
12.13 IL6 IL1B IL1A IFNG CXCL8
33
Th17 Differentiation 65
Show member pathways
 12.09 TLR2 TLR1 IL6 IL4 IL1B IFNG
34
CCL18 signaling pathway 74
12.03 IL6 IL10 CXCL8 CCL2
35
Allograft rejection 74
12.03 CXCL8 IFNG IL10 IL1A IL1B IL2
36
IL27-mediated signaling events 61
Show member pathways
 12.02 IFNG IL10 IL18 IL1B IL2 IL6
37
Innate Lymphoid Cells Differentiation 65
12 TNF IL4 IL2 IL1B IL18 IL10
38
Glucocorticoid receptor regulatory network 61
11.99 IL6 IL4 IL2 IFNG CXCL8
39
Burn wound healing 74
11.98 TNF IL6 IL1B CXCL8 CCL2
40
Dendritic Cells Developmental Lineage Pathway 65
11.98 TNF IL6 IL2 IL1B IL10 IFNG
41
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.93 IL6 CXCL8 CRP CCL2
42
Th17 cell differentiation pathway 74
11.93 IFNG IL1B IL2 IL4 IL6
43
Extrafollicular B cell activation by SARS-CoV-2 74
11.93 CRP IFNG IL10 IL2 IL4 IL6
44
Acute viral myocarditis 74
11.92 IL6 IL2 IL10 IFNG
45
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 61
Show member pathways
 11.91 TNF IL4 IL2 IFNG CXCL8
46
Lung fibrosis 74
11.9 TNF IL6 IL4 IL1B CXCL8 CCL2
47
miRNAs involvement in the immune response in sepsis 74
11.89 TNF LCN2 IL6 IL1A IL10 CXCL8
48
AP-1 transcription factor network 61
11.89 IL6 IL4 IL2 IL10 IFNG CXCL8
49
IL 10 signaling pathway 67
11.88 TNF PIK3C2A IL6 IL1B IL1A IL10
50
Activation of NF-KappaB by PKR 64
Show member pathways
 11.84 TNF IL1B IFNG
Sources

GO Terms for Leptospirosis

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Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 CCL2 CRP CXCL8 F2 IFNG IL10
2 extracellular space GO:0005615 9.77 CCL2 CRP CXCL8 F2 IFNG IL10
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.46 TLR2 TLR1

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.67 IL10 IL18 IL1A IL1B IL2 IL4
2 signal transduction GO:0007165 10.61 CCL2 CXCL8 IFNG IL10 IL18 IL1B
3 negative regulation of cell population proliferation GO:0008285 10.44 CXCL8 IL10 IL1A IL1B IL6 TLR2
4 positive regulation of DNA-binding transcription factor activity GO:0051091 10.33 TNF IL6 IL1B IL10
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.32 IL18 IL1B IL6 TLR2 TNF
6 positive regulation of gene expression GO:0010628 10.3 CRP CXCL8 IFNG IL18 IL1A IL1B
7 positive regulation of tumor necrosis factor production GO:0032760 10.29 TLR2 TLR1 IL6 IL1A IFNG
8 defense response to Gram-positive bacterium GO:0050830 10.29 TNF TLR2 IL6 IL1B IL18 CRP
9 positive regulation of type II interferon production GO:0032729 10.28 TNF IL2 IL1B IL18
10 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.27 TNF TLR2 IL1B IL18
11 cellular response to lipopolysaccharide GO:0071222 10.27 TNF IL6 IL1B IL1A IL10 CXCL8
12 positive regulation of inflammatory response GO:0050729 10.26 IFNG IL18 IL1B IL2 TLR2 TNF
13 humoral immune response GO:0006959 10.25 TNF IL6 IFNG CCL2
14 cellular response to organic cyclic compound GO:0071407 10.22 TNF IL1B IL18 CCL2
15 positive regulation of interleukin-8 production GO:0032757 10.22 IL1B IL6 TLR1 TLR2 TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 10.21 TNF IL1B IFNG
17 positive regulation of interleukin-10 production GO:0032733 10.21 TLR2 IL6 IL4
18 regulation of insulin secretion GO:0050796 10.21 TNF IL6 IL1B IFNG
19 acute-phase response GO:0006953 10.2 CRP F2 IL6
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.2 TNF IL1B IL1A
21 positive regulation of T cell proliferation GO:0042102 10.2 IL6 IL4 IL2 IL1B
22 positive regulation of mitotic nuclear division GO:0045840 10.19 TNF IL1B IL1A
23 liver regeneration GO:0097421 10.19 TNF IL6 IL10
24 positive regulation of vascular endothelial growth factor production GO:0010575 10.19 IL6 IL1B IL1A
25 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.19 TNF IL6 IL10 F2
26 positive regulation of cytokine production GO:0001819 10.19 TNF IL1B IL1A IL10 IFNG
27 positive regulation of immunoglobulin production GO:0002639 10.18 IL6 IL2 IL10
28 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 10.18 IL4 IL2 IL1B IL1A
29 positive regulation of interleukin-17 production GO:0032740 10.17 IL18 IL2 IL6
30 negative regulation of neurogenesis GO:0050768 10.17 IL1B IL6 TNF
31 inflammatory response GO:0006954 10.16 CCL2 CRP CXCL8 IL18 IL1A IL1B
32 positive regulation of glial cell proliferation GO:0060252 10.15 TNF IL6 IL1B
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 10.15 TLR2 IFNG CCL2
34 microglial cell activation GO:0001774 10.15 TNF TLR2 IL4 IFNG
35 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 10.15 TNF IL6 IL4 IL2 IL18 IFNG
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 10.14 TNF IL1B IFNG
37 response to lipopolysaccharide GO:0032496 10.13 TNF TLR2 IL1B IL1A IL10
38 lipopolysaccharide-mediated signaling pathway GO:0031663 10.13 TNF TLR2 IL1B IL18 CCL2
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.12 IL10 IL1B TNF
40 astrocyte activation GO:0048143 10.12 TNF IL1B IFNG
41 positive regulation of MHC class II biosynthetic process GO:0045348 10.11 IL4 IL10 IFNG
42 positive regulation of interleukin-6 production GO:0032755 10.1 TNF TLR2 TLR1 IL6 IL1B IL1A
43 negative regulation of lipid storage GO:0010888 10.08 CRP IL6 TNF
44 positive regulation of mononuclear cell migration GO:0071677 10.04 TNF IL4
45 vascular endothelial growth factor production GO:0010573 10.04 IL1B IL6 TNF
46 cellular response to bacterial lipopeptide GO:0071221 10.03 TLR2 TLR1
47 negative regulation of cytokine production involved in immune response GO:0002719 10.03 TNF IL10
48 positive regulation of fever generation GO:0031622 10.03 TNF IL1B
49 cell activation GO:0001775 10.03 TNF TLR2 TLR1
50 type 2 immune response GO:0042092 10.03 IL10 IL18 IL4

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.65 IL6 IL4 IL2 IL10 F2
2 cytokine activity GO:0005125 9.62 TNF IL6 IL4 IL2 IL1B IL1A
Sources

Sources for Leptospirosis

About this section
2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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