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MCID: LPT001
MIFTS: 62

Leptospirosis

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Leptospirosis

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MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 12 76 53 59 55 3 44 15 73
Weil Disease 53 44 73
Hemorrhagic Jaundice 53 73
Stuttgart Disease 53 73
Fort Bragg Fever 12 73
Canicola Fever 53 73
Leptospirosis Icterohaemorrhagica 12
Equine Infectious Anemia 73
Icterohemorrhagic Fever 53
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 73
Swineherd's Disease 53
Cane-Cutter Fever 53
Nanukayami Fever 12
Rice-Field Fever 53
Weil's Disease 12
Weil Syndrome 76
Swamp Fever 53
Nanukayami 73
Mud Fever 53

Characteristics:

Orphanet epidemiological data:

59
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:2297
ICD10 33 A27 A27.0 A27.9
ICD9CM 35 100 100.0 100.9
NCIt 50 C84825
Orphanet 59 ORPHA509
ICD10 via Orphanet 34 A27.8 A27.9 A27.0
MESH via Orphanet 45 D007922
UMLS via Orphanet 74 C0023364
Sources

Summaries for Leptospirosis

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Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to scrub typhus and respiratory failure. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all.

Wikipedia : 76 Leptospirosis is an infection caused by corkscrew-shaped bacteria called Leptospira. Signs and symptoms... more...

Sources

Related Diseases for Leptospirosis

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Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 468)
# Related Disease Score Top Affiliating Genes
1 scrub typhus 30.4 CRP IL10 IL1B TLR2 TNF
2 respiratory failure 30.1 CRP CXCL8 PIK3C2A TNF
3 vasculitis 30.0 TNF CRP CCL2
4 acute respiratory distress syndrome 30.0 CXCL8 IL1B IL6 TNF
5 aseptic meningitis 30.0 CXCL8 IFNG IL10 IL1B TNF
6 brucellosis 30.0 CRP CXCL8 IFNG IL10 IL6 TNF
7 acute pancreatitis 29.9 CRP CXCL8 IL10 IL6
8 hepatitis a 29.8 F2 IFNG IL10 TNF
9 hemorrhagic fever with renal syndrome 29.7 CRP CXCL8 IL6 TNF
10 hepatitis e 29.7 F2 IFNG TNF
11 cardiogenic shock 29.7 IL6 PIK3C2A TNF
12 hemorrhagic fever 29.7 F2 IFNG IL10 IL6 TNF
13 crimean-congo hemorrhagic fever 29.7 IL6 PIK3C2A TNF
14 anterior uveitis 29.7 IL6 TLR2 TNF
15 chikungunya 29.7 CCL2 IL1B IL6 TNF
16 end stage renal failure 29.7 TNF IL6 CRP
17 uveitis 29.7 CCL2 IFNG IL10 TNF
18 avian influenza 29.6 CXCL8 IL6 TNF
19 reactive arthritis 29.6 CRP IFNG IL10 TNF
20 toxoplasmosis 29.6 IFNG IL10 IL1B IL6 TLR2 TNF
21 purpura 29.6 CRP F2 IL6 TNF
22 cholangitis 29.6 CRP F2 IL6 TNF
23 melioidosis 29.6 IFNG IL10 IL6 TLR1 TLR2 TNF
24 transverse myelitis 29.6 CXCL8 IL10 IL6 TNF
25 q fever 29.4 TNF TLR2 TLR1 IL6 IL1B IL10
26 adult respiratory distress syndrome 29.4 CXCL8 F2 IL10 IL6 TNF
27 lyme disease 29.3 CRP IL1B IL6 TLR1 TLR2 TNF
28 kawasaki disease 29.3 CCL2 CRP IL10 IL6 TNF
29 central nervous system vasculitis 29.2 CRP IFNG IL1B IL6 TNF
30 pericarditis 29.2 CRP IFNG IL1B IL6 TNF
31 viral infectious disease 29.0 CXCL8 IFNG IL10 IL1B IL6 TNF
32 malaria 29.0 CCL2 CRP CXCL8 IFNG IL10 IL1B
33 diabetes mellitus 29.0 CRP IFNG IL1B IL6 PIK3C2A TNF
34 meningitis 29.0 TNF TLR2 IL6 IL1B IL10 IFNG
35 arthritis 28.7 CCL2 CXCL8 IFNG IL10 IL1B IL6
36 chlamydia 28.7 TNF TLR2 IL6 IL1B IL10 IFNG
37 pneumonia 28.5 TNF TLR2 PIK3C2A IL6 IL1B IL10
38 peritonitis 28.0 TNF TLR2 IL6 IL1B IL10 F2
39 dengue disease 11.4
40 leri-weill dyschondrosteosis 11.1
41 moyamoya disease 1 11.1
42 punctate inner choroidopathy 10.3 IL10 TNF
43 tropical endomyocardial fibrosis 10.3 TNF IL10
44 endomyocardial fibrosis 10.3 TNF IL10
45 multifocal choroiditis 10.3 TNF IL10
46 microscopic polyangiitis 10.3 TNF IL10
47 malignant otitis externa 10.3 F2 CRP
48 drug reaction with eosinophilia and systemic symptoms 10.3 TNF CRP
49 cholecystitis 10.3
50 pancreatitis 10.3

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Familial Atrial Fibrillation Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis
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Symptoms & Phenotypes for Leptospirosis

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GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 AQP1 CXCL8 F2 IL10 IL1B TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 AQP1 CXCL8 F2 IL10 IL1B TNF

MGI Mouse Phenotypes related to Leptospirosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.3 AQP1 CRP F2 IFNG IL10 IL1B
2 homeostasis/metabolism MP:0005376 10.23 AQP1 CRP F2 IFNG IL10 IL1B
3 hematopoietic system MP:0005397 10.22 AQP1 F2 IFNG IL10 IL1B IL6
4 immune system MP:0005387 10.21 CCL2 CRP F2 IFNG IL10 IL1B
5 behavior/neurological MP:0005386 10.19 AQP1 F2 IFNG IL10 IL6 PIK3C2A
6 growth/size/body region MP:0005378 10.19 AQP1 F2 IFNG IL10 IL1B IL6
7 digestive/alimentary MP:0005381 10.05 F2 IFNG IL10 IL6 SLC9A3 TLR2
8 integument MP:0010771 10.01 F2 IFNG IL10 IL1B IL6 SLC12A1
9 nervous system MP:0003631 9.97 AQP1 F2 IFNG IL10 IL1B IL6
10 neoplasm MP:0002006 9.85 IFNG IL10 IL1B IL6 TLR2 TNF
11 renal/urinary system MP:0005367 9.8 AQP1 IFNG IL6 PIK3C2A SLC12A1 SLC9A3
12 reproductive system MP:0005389 9.76 AQP1 F2 IFNG IL10 IL6 SLC12A1
13 respiratory system MP:0005388 9.5 AQP1 F2 IFNG IL10 IL6 TLR2
14 skeleton MP:0005390 9.28 AQP1 F2 IFNG IL10 IL1B IL6
Sources

Drugs & Therapeutics for Leptospirosis

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Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
3 Hormones Phase 2, Phase 3
4 Gastrointestinal Agents Phase 2, Phase 3
5 Natriuretic Agents Phase 2, Phase 3
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
7 Arginine Vasopressin Phase 2, Phase 3
8
protease inhibitors Phase 2, Phase 3
9 arginine Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Deamino Arginine Vasopressin Phase 2, Phase 3
12 Antiemetics Phase 2, Phase 3
13 Anti-Inflammatory Agents Phase 2, Phase 3
14 HIV Protease Inhibitors Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Coagulants Phase 2, Phase 3
17 Hemostatics Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3
19 Hormone Antagonists Phase 2, Phase 3
20 BB 1101 Phase 2, Phase 3
21 Vasopressins Phase 2, Phase 3
22 Autonomic Agents Phase 2, Phase 3
23
Ivermectin Approved, Investigational, Vet_approved Not Applicable 70288-86-7 6474909
24
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
25
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
26 Sugarcane Approved Not Applicable
27
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
28 tannic acid Approved Not Applicable
29
Dimenhydrinate Approved Not Applicable 523-87-5 441281
30
Ethanol Approved 64-17-5 702
31
Doxycycline Approved, Investigational, Vet_approved Early Phase 1 564-25-0 54671203
32
Tetracycline Approved, Vet_approved Early Phase 1 60-54-8 5353990
33 Immunologic Factors
34 Immunoglobulins ,Not Applicable
35 Antibodies ,Not Applicable
36 Vaccines
37 Antibiotics, Antitubercular Not Applicable
38 Antitubercular Agents Not Applicable
39 Anti-Infective Agents Not Applicable,Early Phase 1
40 Anti-Bacterial Agents Not Applicable,Early Phase 1
41 Antiparasitic Agents Early Phase 1
42 Antimalarials Early Phase 1
43 Antiprotozoal Agents Early Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Desmopressin and Dexamethasone Adjunctive Treatment for Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
2 Immune Response After Leptospirosis Infection Unknown status NCT02898519
3 Seroprevalence Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Completed NCT03497572
4 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
5 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
6 CKDu in Sugarcane Workers in Guatemala Completed NCT03049527 Not Applicable
7 The Impact of C-reactive Protein Testing Completed NCT02758821 Not Applicable
8 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Recruiting NCT02000635
9 French West Indies Leptospirosis Study Active, not recruiting NCT01607047
10 Scrub Typhus RDT Study Active, not recruiting NCT03269266
11 Oral Doxycycline for the Prevention of Syphilis in Men Who Have Sex With Men Not yet recruiting NCT02864550 Early Phase 1 Doxycycline

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

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Genetic Tests for Leptospirosis

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Anatomical Context for Leptospirosis

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MalaCards organs/tissues related to Leptospirosis:

41
Testes, Kidney, Lung, Liver, Heart, Eye, Brain
Sources

Publications for Leptospirosis

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Articles related to Leptospirosis:

(show top 50) (show all 1179)
# Title Authors Year
1
Socio-epidemiological characterization of human leptospirosis in the Federal District, Brazil, 2011-2015. ( 29972572 )
2018
2
Leptospirosis Health Intervention Module Effect on Knowledge, Attitude, Belief, and Practice among Wet Market Workers in Northeastern Malaysia: An Intervention Study. ( 29970799 )
2018
3
Chimeras could help in the fight against leptospirosis. ( 29350615 )
2018
4
Report of a case of leptospirosis: the importance of asking the patient about workplace factors. ( 29437314 )
2018
5
A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity. ( 29758037 )
2018
6
Leptospirosis presenting as haemolytic uraemic syndrome: a case report. ( 29378539 )
2018
7
Risk factors for human acute leptospirosis in northern Tanzania. ( 29879114 )
2018
8
Prevalence of Bovine Viral Diarrhoea Virus (BVDV), Bovine Herpes Virus 1 (BHV 1), Leptospirosis and Neosporosis, and associated risk factors in 161 Irish beef herds. ( 29304782 )
2018
9
Leptospirosis Pathophysiology: Into the Storm of Cytokines. ( 29974037 )
2018
10
Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection. ( 29452258 )
2018
11
Travel-related leptospirosis in the Netherlands 2009-2016: An epidemiological report and case series. ( 29753855 )
2018
12
Knowledge, attitude and practice about leptospirosis prevention among town service workers in northeastern Malaysia: a cross sectional study. ( 29938244 )
2018
13
Challenges in the diagnosis of leptospirosis outwith endemic settings: a Scottish single centre experience. ( 29741518 )
2018
14
Seroprevalence and risk factor analysis of human leptospirosis in distinct climatic regions of Pakistan. ( 29407239 )
2018
15
Leptospirosis in Caspian Sea littoral, Gilan Province, Iran. ( 29407848 )
2018
16
Changing trend in the seroprevalence and risk factors of human leptospirosis in the South Andaman Island, India. ( 29873192 )
2018
17
Diagnosis of Human Leptospirosis in a Clinical Setting: Real-Time PCR High Resolution Melting Analysis for Detection of Leptospira at the Onset of Disease. ( 29907838 )
2018
18
Unusual ocular clinical manifestation of leptospirosis. ( 29398239 )
2018
19
Pathology and pathogenesis of human leptospirosis: a commented review. ( 29846473 )
2018
20
High incidence of leptospirosis in an observational study of hospital outpatients in Vanuatu highlights the need for improved awareness and diagnostic capacities. ( 29864127 )
2018
21
Evaluation of a novel outer membrane surface-exposed protein, LIC13341 of Leptospira, as an adhesin and serodiagnostic candidate marker for leptospirosis. ( 29969088 )
2018
22
Epidemiological shift and geographical heterogeneity in the burden of leptospirosis in China. ( 29866175 )
2018
23
Factors associated with severity and mortality in patients with confirmed leptospirosis at a regional hospital in northern Taiwan. ( 29934034 )
2018
24
Pathogen-specific leptospiral proteins in urine of patients with febrile illness aids in differential diagnosis of leptospirosis from dengue. ( 29332210 )
2018
25
Leptospirosis in Coastal South India: A Facility Based Study. ( 29862254 )
2018
26
Knowledge, attitudes and practices (KAP) regarding leptospirosis among residents of riverside settlements of Santa Fe, Argentina. ( 29734328 )
2018
27
Investigation of infectious reproductive pathogens of large ruminants: Are neosporosis, brucellosis, leptospirosis and BVDV of relevance in Lao PDR? ( 29024616 )
2018
28
Leptospirosis presenting as severe cardiogenic shock: A case report. ( 30505346 )
2018
29
Fatal Dengue, Chikungunya and Leptospirosis: The Importance of Assessing Co-infections in Febrile Patients in Tropical Areas. ( 30486238 )
2018
30
Bilateral facial paralysis associated with leptospirosis. ( 30369663 )
2018
31
Acute kidney disease related to leptospirosis. ( 30107956 )
2018
32
Cardiac involvement in critically ill patients with leptospirosis: A prospective study using myocardial deformation imaging. ( 30407069 )
2018
33
Geographical and temporal distribution of the residual clusters of human leptospirosis in China, 2005-2016. ( 30413773 )
2018
34
Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design. ( 30418677 )
2018
35
Macrophages and Galectin 3 Control Bacterial Burden in Acute and Subacute Murine Leptospirosis That Determines Chronic Kidney Fibrosis. ( 30425972 )
2018
36
MAT cross-reactions or vaccine cross-protection: retrospective study of 863 leptospirosis canine cases. ( 30426097 )
2018
37
Seroprevalence and distribution of leptospirosis serovars among wet market workers in northeastern, Malaysia: a cross sectional study. ( 30428852 )
2018
38
Evaluation of an in-house LipL32 polymerase chain reaction for diagnosis of leptospirosis and its correlation with various serological diagnostic techniques. ( 30429392 )
2018
39
Immuno-informatics based approaches to design a novel multi epitope-based vaccine for immune response reinforcement against Leptospirosis. ( 30448609 )
2018
40
Locally Acquired Leptospirosis in Expedition Racer, Manitoba, Canada. ( 30457535 )
2018
41
Compatibility between a rabies vaccine and a combined vaccine against canine distemper, adenovirosis, parvovirosis, parainfluenza virus and leptospirosis. ( 30459006 )
2018
42
Peridomestic small Indian mongoose: An invasive species posing as potential zoonotic risk for leptospirosis in the Caribbean. ( 30465742 )
2018
43
Diagnostic accuracy of leptospirosis whole-cell lateral flow assays: a systematic review and meta-analysis. ( 30472422 )
2018
44
Prevalence of dengue and leptospirosis co-infection in a tertiary care hospital in south India. ( 30483374 )
2018
45
A remotely sensed flooding indicator associated with cattle and buffalo leptospirosis cases in Thailand 2011-2013. ( 30497412 )
2018
46
Diagnostic accuracy of rapid diagnostic tests for the early detection of leptospirosis. ( 30502041 )
2018
47
Silver enhanced nano-gold dot blot immunoassay for leptospirosis. ( 30502367 )
2018
48
The monocytosis during human leptospirosis is associated with modest immune cell activation states. ( 30542761 )
2018
49
Human leptospirosis cases in Palermo Italy. The role of rodents and climate. ( 28802826 )
2018
50
A systematic review of leptospirosis on wild animals in Latin America. ( 28967042 )
2018
Sources

Variations for Leptospirosis

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Expression for Leptospirosis

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Search GEO for disease gene expression data for Leptospirosis.
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Pathways for Leptospirosis

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Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.03 CCL2 CRP CXCL8 IFNG IL10 IL1B
2
PEDF Induced Signaling 64
Show member pathways
 13.68 CCL2 CXCL8 F2 IFNG IL10 IL1B
3
TGF-Beta Pathway 64
Show member pathways
 13.56 CCL2 CXCL8 F2 IFNG IL10 IL1B
4
Akt Signaling 64
Show member pathways
 13.45 CCL2 CXCL8 IL10 IL1B IL6 TLR1
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.38 CCL2 CXCL8 IFNG IL10 IL1B IL6
6
PAK Pathway 64
Show member pathways
 13.29 CCL2 CXCL8 IL10 IL1B IL6 TNF
7
IL-2 Pathway 64
Show member pathways
 13.21 IFNG IL1B PIK3C2A TLR1 TLR2 TNF
8
Human cytomegalovirus infection 37
Show member pathways
 13.09 CCL2 CXCL8 IL1B IL6 TLR2 TNF
9
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13.07 CCL2 CXCL8 IFNG IL10 IL1B IL6
10
Allograft rejection 1 37
Show member pathways
 12.93 CXCL8 IFNG IL10 IL1B IL6 TNF
11
Influenza A 37
Show member pathways
 12.89 CCL2 CXCL8 IFNG IL1B IL6 TLR2
12
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.8 CXCL8 IFNG IL1B IL6 TNF
13
NF-KappaB Family Pathway 64
Show member pathways
 12.75 IL1B IL6 TLR1 TLR2 TNF
14
Immune response IL-23 signaling pathway 22
Show member pathways
 12.7 CCL2 F2 IFNG IL10 IL1B IL6
15
Th17 cell differentiation 37
Show member pathways
 12.68 IFNG IL10 IL1B IL6 TLR2 TNF
16
NF-kappaB Signaling 4
12.67 CCL2 IFNG IL10 IL1B TLR1 TLR2
17
T cell receptor signaling pathway 37
Show member pathways
 12.5 IFNG IL10 IL1B IL6 TNF
18
Selenium Micronutrient Network 1
Show member pathways
 12.43 CCL2 CRP F2 IFNG IL1B IL6
19
IL-17 Family Signaling Pathways 65
Show member pathways
 12.41 CCL2 CXCL8 IFNG IL1B IL6 TLR2
20
Toll Comparative Pathway 64
Show member pathways
 12.39 CXCL8 IFNG IL1B IL6 TNF
21
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.36 CXCL8 IL6 TLR1 TLR2 TNF
22
Toxoplasmosis 37
Show member pathways
 12.35 IFNG IL10 IL1B TLR2 TNF
23
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.35 CXCL8 IFNG IL10 IL1B IL6 TNF
24
IL-1 Family Signaling Pathways 65
Show member pathways
 12.32 CXCL8 IL1B IL6 TLR2 TNF
25
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.29 CCL2 CXCL8 F2 IL1B TLR1 TLR2
26
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 CXCL8 IL10 IL1B IL6 SLC9A3 TNF
27
Tuberculosis 37
12.29 IFNG IL10 IL1B IL6 TLR1 TLR2
28
Colorectal Cancer Metastasis 64
12.28 IFNG IL6 TLR1 TLR2 TNF
29
C-type lectin receptor signaling pathway 37
Show member pathways
 12.26 IL10 IL1B IL6 TNF
30
Bacterial infections in CF airways 22
Show member pathways
 12.24 CXCL8 IFNG IL1B IL6 TLR1 TLR2
31
Fluid shear stress and atherosclerosis 37
12.16 CCL2 IFNG IL1B TNF
32
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.16 CCL2 CXCL8 IFNG IL10 IL1B IL6
33
MAPK Pathway 72
Show member pathways
 12.11 IL1B PIK3C2A TLR1 TLR2
34
Interleukin-4 and 13 signaling 66
12.09 CCL2 CXCL8 IL10 IL1B IL6 TNF
35
Th1 Differentiation Pathway 65
Show member pathways
 12.09 IFNG IL10 IL1B IL6 TLR1 TLR2
36
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.07 IFNG IL10 IL6 TNF
37
TNF signaling pathway 37
12.05 CCL2 IL1B IL6 TNF
38
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.05 F2 IFNG IL1B IL6 TLR1 TLR2
39
AGE-RAGE signaling pathway in diabetic complications 37
12.04 CCL2 CXCL8 IL1B IL6 TNF
40
Senescence and Autophagy in Cancer 1
12.03 CXCL8 IFNG IL1B IL6
41
Spinal Cord Injury 1
11.99 AQP1 CCL2 CXCL8 IFNG IL1B IL6
42
Salmonella infection (KEGG) 37
11.93 CXCL8 IFNG IL1B IL6
43
Hematopoietic cell lineage 37
11.91 IL1B IL6 TNF
44
Pertussis 37
11.91 CXCL8 IL10 IL1B IL6 TNF
45
NF-kappa B signaling pathway 37
11.9 CXCL8 IL1B TNF
46
Dendritic Cells Developmental Lineage Pathway 65
11.9 IFNG IL10 IL1B IL6 TNF
47
Innate Lymphoid Cell Differentiation Pathways 65
11.89 IFNG IL10 IL1B TNF
48
Jak-Stat Signaling Pathway (sino) 67
11.87 IFNG IL10 IL6
49
Glucocorticoid receptor regulatory network 1
11.83 CXCL8 IFNG IL6
50
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.8 CXCL8 IFNG TNF
Sources

GO Terms for Leptospirosis

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Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CCL2 CRP CXCL8 F2 IFNG IL10
2 extracellular space GO:0005615 9.28 CCL2 CRP CXCL8 F2 IFNG IL10
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.96 TLR1 TLR2

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.96 F2 IFNG IL1B TNF
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.93 IL1B IL6 TLR2 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.91 CCL2 CXCL8 IL10 IL1B IL6 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.9 IL10 IL1B IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 TLR2 TNF
6 neutrophil chemotaxis GO:0030593 9.87 CCL2 CXCL8 IL1B
7 cellular response to organic cyclic compound GO:0071407 9.86 CCL2 IL1B TNF
8 regulation of insulin secretion GO:0050796 9.86 IFNG IL1B TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL1B TLR2 TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IFNG IL1B TNF
11 response to glucocorticoid GO:0051384 9.83 IL10 IL1B IL6 TNF
12 protein kinase B signaling GO:0043491 9.82 CCL2 IL1B TNF
13 acute-phase response GO:0006953 9.8 CRP F2 IL6
14 positive regulation of interleukin-6 production GO:0032755 9.8 IL1B IL6 TLR2 TNF
15 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR2 TNF
16 humoral immune response GO:0006959 9.78 CCL2 IFNG IL6 TNF
17 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
18 regulation of signaling receptor activity GO:0010469 9.76 CCL2 CXCL8 F2 IFNG IL10 IL1B
19 positive regulation of chemokine production GO:0032722 9.75 IL6 TLR2 TNF
20 positive regulation of glial cell proliferation GO:0060252 9.74 IL1B IL6 TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.73 IFNG IL1B TNF
22 cellular response to lipopolysaccharide GO:0071222 9.73 CCL2 CXCL8 IL10 IL1B IL6 TNF
23 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.71 IL10 TNF
26 positive regulation of interleukin-8 secretion GO:2000484 9.71 TLR1 TLR2
27 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 CCL2 TLR2
28 cellular homeostasis GO:0019725 9.71 AQP1 CCL2
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
30 regulation of cytokine secretion GO:0050707 9.7 TLR1 TLR2
31 cell activation GO:0001775 9.7 TLR1 TLR2
32 PERK-mediated unfolded protein response GO:0036499 9.7 CCL2 CXCL8
33 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
34 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
35 response to molecule of bacterial origin GO:0002237 9.69 CXCL8 IL10 TLR2
36 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.68 IL1B TLR1
37 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
38 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
39 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
40 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TLR2 TNF
41 chronic inflammatory response to antigenic stimulus GO:0002439 9.66 IL1B TNF
42 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
43 cellular response to triacyl bacterial lipopeptide GO:0071727 9.64 TLR1 TLR2
44 receptor biosynthetic process GO:0032800 9.64 IL10 TNF
45 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.63 TLR1 TLR2
46 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
47 detection of triacyl bacterial lipopeptide GO:0042495 9.62 TLR1 TLR2
48 positive regulation of vitamin D biosynthetic process GO:0060557 9.61 IFNG TNF
49 immune response GO:0006955 9.61 CCL2 CXCL8 IFNG IL10 IL1B IL6
50 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B IL6 TNF

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 CCL2 CXCL8 IFNG IL10 IL1B IL6
2 lipopeptide binding GO:0071723 8.96 TLR1 TLR2
Sources

Sources for Leptospirosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
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35 ICD9CM
36 IUPHAR
37 KEGG
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64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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