MCID: LPT001
MIFTS: 66

Leptospirosis

Categories: Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Leptospirosis

MalaCards integrated aliases for Leptospirosis:

Name: Leptospirosis 12 74 52 58 54 3 43 15 17 71 32
Weil Disease 52 43 71
Leptospirosis Icterohaemorrhagica 12 32
Hemorrhagic Jaundice 52 71
Stuttgart Disease 52 71
Fort Bragg Fever 12 71
Canicola Fever 52 71
Equine Infectious Anemia 71
Icterohemorrhagic Fever 52
Rat Catcher's Yellows 12
Spirochetal Jaundice 12
Canine Leptospirosis 71
Swineherd's Disease 52
Cane-Cutter Fever 52
Nanukayami Fever 12
Rice-Field Fever 52
Weil's Disease 12
Weil Syndrome 74
Swamp Fever 52
Nanukayami 71
Mud Fever 52

Characteristics:

Orphanet epidemiological data:

58
leptospirosis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Leptospirosis

CDC : 3 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. Some infected persons, however, may have no symptoms at all. Without treatment, Leptospirosis can lead to kidney damage, meningitis (inflammation of the membrane around the brain and spinal cord), liver failure, respiratory distress, and even death.

MalaCards based summary : Leptospirosis, also known as weil disease, is related to dengue disease and acute kidney failure. An important gene associated with Leptospirosis is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Emtricitabine and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and liver, and related phenotypes are fever and arthralgia

Disease Ontology : 12 A primary bacterial infectious disease that involves systemic infection, has material basis in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly.

Wikipedia : 74 Leptospirosis is a blood infection caused by the bacteria Leptospira. Signs and symptoms can range from... more...

Related Diseases for Leptospirosis

Diseases related to Leptospirosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 994)
# Related Disease Score Top Affiliating Genes
1 dengue disease 32.7 TNF PIK3C2A CD40LG
2 acute kidney failure 31.3 SLC9A3 PIK3C2A LCN2 IL18 F2
3 cardiogenic shock 31.0 PIK3C2A CRP
4 pancreatitis 31.0 TNF IL6 IL1B IL10 CRP
5 bilirubin metabolic disorder 30.9 F2 CRP CD40LG
6 acalculous cholecystitis 30.9 F2 CRP CD40LG
7 epidemic typhus 30.8 TLR2 IL10 CRP CD40LG
8 kidney disease 30.8 SLC12A1 LCN2 IL6 IL18 CRP CCL2
9 disseminated intravascular coagulation 30.8 TNF PIK3C2A IL6 IL10 F2 CRP
10 tracheitis 30.7 TNF IL6 CRP
11 deficiency anemia 30.6 TNF LCN2 IL6 CRP
12 adult respiratory distress syndrome 30.5 TNF IL6 IL1B IL10 F2 CXCL8
13 hypopyon 30.5 TNF IL6 IL10 CRP
14 hantavirus hemorrhagic fever with renal syndrome 30.5 TNF IL6 CRP CD40LG
15 acute myocarditis 30.5 TNF IL1B IL10 CRP
16 anuria 30.4 PIK3C2A LCN2 F2 CRP CD40LG
17 mononeuritis multiplex 30.4 TNF CRP CD40LG
18 transverse myelitis 30.4 TNF IL6 IL10 CXCL8
19 iridocyclitis 30.4 TNF IL6 IL10 CRP CD40LG
20 ornithosis 30.3 PIK3C2A CRP CD40LG
21 mastitis 30.3 TLR2 IL6 IL18 CXCL8
22 pneumonic plague 30.3 TNF TLR2 IL10
23 relapsing fever 30.3 TNF CRP CD40LG
24 systemic autoimmune disease 30.3 IL6 CRP
25 chikungunya 30.3 TNF IL6 IL1B IL18 CCL2
26 fatty liver disease 30.3 TNF IL6 IL1B CXCL8 CRP
27 cavernous sinus thrombosis 30.3 F2 CRP
28 pulmonary edema 30.2 TNF PIK3C2A IL1B IL10 F2 CXCL8
29 intussusception 30.2 IL6 CRP CD40LG
30 chronic meningitis 30.2 IL1B CRP CD40LG
31 spotted fever rickettsiosis 30.2 TNF IL10 IFNG
32 crimean-congo hemorrhagic fever 30.2 TNF PIK3C2A IL6
33 syphilis 30.2 TNF IL6 IFNG F2 CRP CD40LG
34 acute pancreatitis 30.2 TNF IL6 IL1B IL18 IL10 CXCL8
35 congestive heart failure 30.2 TNF PIK3C2A IL6 IL1B CRP
36 panuveitis 30.2 TNF IL6 IL10 CRP CD40LG
37 hepatorenal syndrome 30.2 LCN2 IL18 F2 AQP1
38 spondylitis 30.1 TNF IL6 IL10 IFNG CRP
39 hepatic encephalopathy 30.1 TNF IL6 IL18 F2
40 optic neuritis 30.1 TNF IL6 IL1B IL10 CXCL8
41 antiphospholipid syndrome 30.1 TNF F2 CRP CD40LG
42 lemierre's syndrome 30.1 F2 CRP
43 plague 30.1 TNF TLR2 TLR1 IL6 IL1B IL10
44 acute disseminated encephalomyelitis 30.1 IL1B IL10 CD40LG
45 intracranial hypertension 30.1 TNF IL1B F2 AQP1
46 thrombocytosis 30.0 IL6 IL1B F2 CRP
47 aseptic meningitis 30.0 TNF IL1B IL10 IFNG CXCL8 CRP
48 invasive aspergillosis 30.0 TLR2 TLR1 IL10 IFNG CXCL8
49 avian influenza 30.0 TNF IL6 CXCL8
50 poliomyelitis 30.0 TNF IL4 IL10 IFNG CD40LG

Comorbidity relations with Leptospirosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Leptospirosis:



Diseases related to Leptospirosis

Symptoms & Phenotypes for Leptospirosis

Human phenotypes related to Leptospirosis:

58 31 (show all 40)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
2 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
5 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
6 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
7 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
8 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
9 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
10 hyperproteinemia 58 31 frequent (33%) Frequent (79-30%) HP:0002152
11 conjunctival hyperemia 58 31 frequent (33%) Frequent (79-30%) HP:0030953
12 elevated serum transaminases during infections 58 31 frequent (33%) Frequent (79-30%) HP:0008150
13 hepatomegaly 58 31 occasional (7.5%) Occasional (29-5%) HP:0002240
14 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
15 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
16 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
17 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
18 hemoptysis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002105
19 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
20 lymphadenopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0002716
21 respiratory distress 58 31 occasional (7.5%) Occasional (29-5%) HP:0002098
22 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
23 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
24 first degree atrioventricular block 58 31 occasional (7.5%) Occasional (29-5%) HP:0011705
25 acute kidney injury 58 31 occasional (7.5%) Occasional (29-5%) HP:0001919
26 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
27 pulmonary hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0040223
28 pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0025439
29 cellular urinary casts 58 31 occasional (7.5%) Occasional (29-5%) HP:0031197
30 arrhythmia 58 31 very rare (1%) Very rare (<4-1%) HP:0011675
31 pericarditis 58 31 very rare (1%) Very rare (<4-1%) HP:0001701
32 uveitis 58 31 very rare (1%) Very rare (<4-1%) HP:0000554
33 retinal hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0000573
34 optic neuritis 58 31 very rare (1%) Very rare (<4-1%) HP:0100653
35 subconjunctival hemorrhage 58 31 very rare (1%) Very rare (<4-1%) HP:0011896
36 papilledema 58 31 very rare (1%) Very rare (<4-1%) HP:0001085
37 chorioretinitis 58 31 very rare (1%) Very rare (<4-1%) HP:0012424
38 rhabdomyolysis 58 31 very rare (1%) Very rare (<4-1%) HP:0003201
39 macular cotton wool spot 58 31 very rare (1%) Very rare (<4-1%) HP:0030497
40 morphological abnormality of the central nervous system 58 Occasional (29-5%)

GenomeRNAi Phenotypes related to Leptospirosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.73 AQP1 F2 IL2
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.73 AQP1 CD40LG F2 IL10 IL18 IL1B
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.5 CD40LG CXCL8 IL10 IL18 IL1B LCN2
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.5 AQP1 CXCL8 IL10 IL18 IL1B IL2

MGI Mouse Phenotypes related to Leptospirosis:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.46 AQP1 CD40LG CRP F2 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.41 AQP1 CD40LG CRP F2 IFNG IL10
3 hematopoietic system MP:0005397 10.4 AQP1 CD40LG F2 IFNG IL10 IL18
4 immune system MP:0005387 10.39 CCL2 CD40LG CRP F2 IFNG IL10
5 growth/size/body region MP:0005378 10.36 AQP1 F2 IFNG IL10 IL18 IL1B
6 cellular MP:0005384 10.33 CD40LG F2 IFNG IL10 IL18 IL2
7 endocrine/exocrine gland MP:0005379 10.26 AQP1 CD40LG IFNG IL10 IL2 IL4
8 digestive/alimentary MP:0005381 10.24 F2 IFNG IL10 IL18 IL2 IL4
9 mortality/aging MP:0010768 10.24 AQP1 CD40LG F2 IFNG IL10 IL18
10 adipose tissue MP:0005375 10.17 AQP1 IL18 IL6 LCN2 PIK3C2A SLC9A3
11 integument MP:0010771 10.17 CD40LG F2 IFNG IL10 IL18 IL1B
12 liver/biliary system MP:0005370 10.01 IFNG IL10 IL2 IL4 IL6 LCN2
13 renal/urinary system MP:0005367 9.96 AQP1 CD40LG IFNG IL4 IL6 LCN2
14 reproductive system MP:0005389 9.93 AQP1 CD40LG F2 IFNG IL10 IL2
15 neoplasm MP:0002006 9.87 IFNG IL10 IL1B IL2 IL6 TLR2
16 respiratory system MP:0005388 9.61 AQP1 F2 IFNG IL10 IL2 IL4
17 skeleton MP:0005390 9.36 AQP1 CD40LG F2 IFNG IL10 IL1B

Drugs & Therapeutics for Leptospirosis

Drugs for Leptospirosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
2
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
5 Anti-Infective Agents Phase 4
6 Anti-HIV Agents Phase 4
7 Antiviral Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Antiparasitic Agents Phase 4
10 Reverse Transcriptase Inhibitors Phase 4
11 Antimalarials Phase 4
12 Anti-Retroviral Agents Phase 4
13 Anti-Bacterial Agents Phase 4
14 Antibiotics, Antitubercular Phase 4
15
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
17 Gastrointestinal Agents Phase 2, Phase 3
18 Hemostatics Phase 2, Phase 3
19 Deamino Arginine Vasopressin Phase 2, Phase 3
20 Antineoplastic Agents, Hormonal Phase 2, Phase 3
21 Hormones Phase 2, Phase 3
22 Antiemetics Phase 2, Phase 3
23 Hormone Antagonists Phase 2, Phase 3
24 Arginine Vasopressin Phase 2, Phase 3
25 glucocorticoids Phase 2, Phase 3
26 Vasopressins Phase 2, Phase 3
27 Coagulants Phase 2, Phase 3
28 Anti-Inflammatory Agents Phase 2, Phase 3
29
Arginine Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322
30
Albendazole Approved, Vet_approved 54965-21-8 2082
31
Mebendazole Approved, Vet_approved 31431-39-7 4030
32
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 6474909
33
Ethanol Approved 64-17-5 702
34 Antibodies
35 Vaccines
36 Immunoglobulins
37 Immunoglobulins, Intravenous
38 Immunologic Factors
39 Immunoglobulin M
40 Immunoglobulin G

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Use of Tenofovir/Emtricitabine With Immediate or Deferred Doxycycline 100mg PO Daily for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative Men Who Have Sex With Men: a Pilot Study of Dual Daily HIV and Syphilis PrEP. (The DuDHS Trial). Active, not recruiting NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
2 Multicenter, Randomized, Open-label Non-inferiority Trial, Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte) Not yet recruiting NCT04211649 Phase 4 3 days of antibiotherapy
3 An Open Randomized Controlled Trial of Desmopressin, and Dexamethasone as Adjunctive Therapy in Patients With Pulmonary Hemorrhage Associated With Leptospirosis Terminated NCT00592566 Phase 2, Phase 3 Dexamethasone, desmopressin
4 Serological Response in Patients Infected by Leptospirosis 1 to 7 Years Earlier Unknown status NCT02898519
5 Utility of Quantitative Polymerase Chain Reaction to Predict Clinical Outcome of Leptospirosis in French West Indies Unknown status NCT01607047
6 Severe Leptospirosis in Non-tropical Areas: a Nationwide, Multicentre, Retrospective Study in French ICUs Completed NCT03912506
7 Seroprevalence, Multi-center, Phase IV Cross-sectional Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Completed NCT03497572
8 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
9 Indian Intensive Care Case Mix and Practice Patterns Study Completed NCT01384929
10 A Single-blind Stepped Wedge Cluster Randomized Controlled Behaviour Change Trial to Determine Effectiveness of Prevention Programme of Melioidosis in Diabetics in Ubon Ratchathani, Northeast Thailand Completed NCT02089152
11 Evaluation of Rapid Diagnostic Tests (RDT) in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases (NTD) in Patients Presenting With Persistent Fever (≥1 Week) in Cambodia, Nepal, Democratic Republic of the Congo and Sudan Completed NCT01766830
12 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Completed NCT03269266
13 The Impact of C-reactive Protein Testing on Antibiotic Prescription in Febrile Patients Attending Primary Care in Low-resource Settings Completed NCT02758821
14 Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Recruiting NCT02000635
15 Leptospirosis Registry - LeptoScope Recruiting NCT04288674
16 Cohort of Hospitalized Patients Suspected of Leptospirosis Not yet recruiting NCT04034550

Search NIH Clinical Center for Leptospirosis

Cochrane evidence based reviews: leptospirosis

Genetic Tests for Leptospirosis

Anatomical Context for Leptospirosis

MalaCards organs/tissues related to Leptospirosis:

40
Testes, Kidney, Liver, Lung, Skin, Eye, Brain

Publications for Leptospirosis

Articles related to Leptospirosis:

(show top 50) (show all 7225)
# Title Authors PMID Year
1
Nephropathia epidemica and leptospirosis in Champagne-Ardenne, France: comparison of clinical, biological and epidemiological profiles. 61 54
19229563 2009
2
Evaluation of leptospiral recombinant antigens MPL17 and MPL21 for serological diagnosis of leptospirosis by enzyme-linked immunosorbent assays. 61 54
18799647 2008
3
Recombinant multiepitope protein for diagnosis of leptospirosis. 61 54
18827193 2008
4
Leptospirosis vaccines. 61 54
18072968 2007
5
Screening of patients with acute febrile illness for leptospirosis using clinical criteria and serology. 54 61
16433137 2005
6
Leptospirosis presenting with mania and psychosis: four consecutive cases seen in a military hospital in Turkey. 61 54
16480244 2005
7
Preliminary survey of leptospirosis amongst febrile patients from urban slums of East Delhi. 54 61
12839344 2003
8
Evaluation of the clinical utility of a rapid blood test for human leptospirosis. 54 61
12007438 2002
9
Evaluation of recombinant Leptospira antigen-based enzyme-linked immunosorbent assays for the serodiagnosis of leptospirosis. 61 54
11526167 2001
10
Lateral-flow assay for rapid serodiagnosis of human leptospirosis. 54 61
11139212 2001
11
International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human serum specimens. 54 61
10449473 1999
12
Field evaluation of a one-step dipstick assay for the diagnosis of human leptospirosis in the Seychelles. 54 61
10203172 1999
13
Macroscopic agglutination test for rapid diagnosis of human leptospirosis. 61 54
9774553 1998
14
Evaluation of the indirect hemagglutination assay for diagnosis of acute leptospirosis. 54 61
9431911 1998
15
High seroprevalence of anti-Leptospira spp. antibodies in domestic and wild mammals from a mixed use rescue center in Ecuador: Lessons for "One Health" based conservation strategies. 61
32426447 2020
16
Research status and perspectives for pathogenic spirochete vaccines. 61
32272157 2020
17
Spatial distribution of leptospirosis incidence in the Upper Yangtze and Pearl River Basin, China: Tools to support intervention and elimination. 61
32298905 2020
18
Leptospira spp., a genus in the stage of diversity and genomic data expansion. 61
32061688 2020
19
Use of serological and molecular techniques for detection of Leptospira sp. carrier sheep under semiarid conditions and the importance of genital transmission route. 61
32330452 2020
20
Epidemiology, clinical and laboratory findings of leptospirosis in Southwestern Greece. 61
32178560 2020
21
A graveyard keeper with severe hyperbilirubinemia caused by leptospirosis. 61
32518036 2020
22
Epidemiological, clinical and laboratory features of leptospirosis compared to other acute febrile illnesses. 61
32568280 2020
23
Lethal Outcome of Leptospirosis in Southern Russia: Characterization of Leptospira Interrogans Isolated from a Deсeased Teenager. 61
32545855 2020
24
Investigation of Leptospira Infection in Stray Animals in Songkhla, Thailand: Leptospirosis Risk Reduction in Human. 61
31905047 2020
25
Clinical and biochemical differences between hantavirus infection and leptospirosis: a retrospective analysis of a patient series in Belgium. 61
30882283 2020
26
Identifying factors associated with treatment delay in leptospirosis: A retrospective study of patients admitted to hospital in Reunion (Indian Ocean) between 2014 and 2015. 61
31582278 2020
27
Detection of Leptospira interrogans in Hedgehogs from Central China. 61
32155388 2020
28
Atypical case of hantavirus infection in Sri Lanka mimicking leptospirosis: a case report. 61
32552909 2020
29
Chikungunya in Indonesia: Epidemiology and diagnostic challenges. 61
32479497 2020
30
Leptospira Infection in African Green Monkeys in an Endemic Area: An Opportunity for Comparative Studies in a Natural Environment. 61
32560055 2020
31
Leptospira interrogans in wild Boa constrictor snakes from Northeast Brazil peri‑urban rainforest fragments. 61
32504590 2020
32
Raccoons (Procyon lotor) and Striped Skunks (Mephitis mephitis) as Potential Reservoirs of Leptospira spp. in California. 61
32017860 2020
33
The zoonotic pathogen Leptospira interrogans mitigates environmental stress through cyclic-di-GMP-controlled biofilm production. 61
32532998 2020
34
Weil's disease in a young homeless man living in Lisbon. 61
32532903 2020
35
Crested Porcupine (Hystrix cristata L.): A New Potential Host for Pathogenic Leptospira Among Semi-Fossorial Mammals. 61
32208192 2020
36
Optimization of Culture Protocols to Isolate Leptospira spp. from Environmental Water, Field Investigation, and Identification of Factors Associated with the Presence of Leptospira spp. in the Environment. 61
32517121 2020
37
Isolation and propagation of leptospires at 37 °C directly from the mammalian host. 61
32541841 2020
38
Detection of New Leptospira Genotypes Infecting Symptomatic Dogs: Is a New Vaccine Formulation Needed? 61
32570803 2020
39
Leptospirosis trends in China, 2007-2018: A retrospective observational study. 61
31765064 2020
40
[Epidemiological characteristics of leptospirosis in Sichuan province, 2004-2018]. 61
32447909 2020
41
The Predictive Factors for Severe Leptospirosis Cases in Kedah. 61
32422911 2020
42
Pathology and Host Immune Evasion During Human Leptospirosis: a Review. 61
30875033 2020
43
Fatal Rodentborne Leptospirosis in Prison Inmates, South Africa, 2015. 61
32310070 2020
44
Prevalence of leptospirosis in vaccinated working dogs and humans with occupational risk 61
32463609 2020
45
Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review. 61
31898795 2020
46
Estimating acute human leptospirosis incidence in northern Tanzania using sentinel site and community behavioural surveillance. 61
32374085 2020
47
Frequency of Animal Leptospirosis in the Southern United States and the Implications for Human Health. 61
32358619 2020
48
Seroprevalence of leptospirosis in an endemic mixed urban and semi-urban setting-A community-based study in the district of Colombo, Sri Lanka. 61
32428003 2020
49
Identification of Serogroups Australis and Icterohaemorrhagiae in Two Dogs with a Severe Form of Acute Leptospirosis in Italy. 61
32384672 2020
50
Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results. 61
32448167 2020

Variations for Leptospirosis

Expression for Leptospirosis

Search GEO for disease gene expression data for Leptospirosis.

Pathways for Leptospirosis

Pathways related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 TNF TLR2 TLR1 LCN2 IL6 IL4
2
Show member pathways
13.93 TNF IL6 IL4 IL2 IL1B IL18
3
Show member pathways
13.82 TNF IL6 IL4 IL2 IL1B IL18
4
Show member pathways
13.69 TNF IL6 IL4 IL2 IL1B IL18
5
Show member pathways
13.58 TNF TLR2 TLR1 IL6 IL4 IL2
6
Show member pathways
13.53 TNF LCN2 IL6 IL4 IL2 IL1B
7
Show member pathways
13.46 TNF IL6 IL4 IL2 IL1B IL18
8
Show member pathways
13.33 TNF TLR2 TLR1 PIK3C2A IL4 IL2
9
Show member pathways
13.25 TNF TLR2 TLR1 IL6 IL2 IL1B
10
Show member pathways
13.05 TNF IL6 IL4 IL2 IL1B IL10
11
Show member pathways
13.04 TNF TLR2 IL6 IL1B CXCL8 CCL2
12
Show member pathways
13.01 TNF TLR2 IL6 IL2 IL1B IL18
13 12.96 IL6 IL4 IL2 IFNG F2 CXCL8
14 12.92 TNF TLR2 IL6 IL1B IFNG CCL2
15
Show member pathways
12.9 TNF TLR2 TLR1 IL6 IL1B IL18
16
Show member pathways
12.88 TNF TLR2 TLR1 IL6 IL2 IL1B
17
Show member pathways
12.81 TNF IL4 IL2 IL18 IL10 IFNG
18
Show member pathways
12.81 TNF TLR2 IL6 IL4 IL2 IL1B
19
Show member pathways
12.8 TNF TLR2 IL6 IL4 IL2 IL1B
20
Show member pathways
12.78 TNF IL6 IL2 IL1B IL18 IL10
21
Show member pathways
12.69 TNF TLR2 TLR1 IL1B CD40LG
22 12.67 TNF TLR2 TLR1 IL4 IL2 IL1B
23
Show member pathways
12.56 IL6 IL4 IL2 IL10 IFNG
24
Show member pathways
12.55 TNF IL6 IL2 IL18 IL10 CXCL8
25 12.5 TNF TLR2 IL6 IL1B IL18 CXCL8
26
Show member pathways
12.5 TNF TLR2 LCN2 IL6 IL4 IL1B
27
Show member pathways
12.49 TNF TLR2 IL4 IL1B IL10 IFNG
28
Show member pathways
12.48 TNF IL6 IL4 IL2 IL1B IFNG
29
Show member pathways
12.47 TNF IL6 IL4 IL2 IL1B IL18
30 12.46 TNF IL6 IL1B IL18 F2 CXCL8
31
Show member pathways
12.44 TNF IL6 IL1B IFNG CXCL8
32 12.43 TNF IL6 IL1B IL18 CXCL8 CCL2
33 12.43 TNF TLR2 TLR1 IL6 IL1B IL18
34
Show member pathways
12.42 TNF TLR2 TLR1 IL6 CXCL8
35
Show member pathways
12.38 TNF TLR2 TLR1 IL6 IL4 IL1B
36
Show member pathways
12.37 TNF IL6 IL2 IL1B IL10
37 12.37 TNF SLC9A3 IL6 IL1B IL10 CXCL8
38 12.35 TNF TLR2 TLR1 IL6 IFNG
39
Show member pathways
12.22 TLR2 TLR1 PIK3C2A IL2 IL1B
40 12.22 TNF IL6 IL4 IL2 IL10 IFNG
41 12.2 TNF IL1B IFNG CCL2
42
Show member pathways
12.17 IL4 IL2 IL1B IL18 IFNG
43 12.16 TNF IL6 IL2 IL1B IL18 IL10
44 12.14 TNF TLR2 IL6 IL1B IL10 IFNG
45 12.11 TNF IL6 IL1B CXCL8 CCL2
46 12.1 TNF IL6 IL1B CCL2
47
Show member pathways
12.1 TLR2 TLR1 IL6 IL4 IL1B IFNG
48 12.1 TNF IL6 IL4 IL2 IL1B IFNG
49 12.07 IL6 IL1B IFNG CXCL8
50 12.06 TNF IL1B CXCL8 CD40LG

GO Terms for Leptospirosis

Cellular components related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF LCN2 IL6 IL4 IL2 IL1B
2 cell GO:0005623 9.76 SLC9A3 SLC12A1 LCN2 IL6 IL2 F2
3 extracellular space GO:0005615 9.47 TNF LCN2 IL6 IL4 IL2 IL1B
4 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.26 TLR2 TLR1

Biological processes related to Leptospirosis according to GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.37 TLR2 TLR1 IL6 IL4 IL1B IL18
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.29 TNF TLR2 IL6 IL4 IL2 IL1B
3 positive regulation of cell proliferation GO:0008284 10.19 IL6 IL4 IL2 IL1B IFNG F2
4 negative regulation of apoptotic process GO:0043066 10.18 IL6 IL4 IL2 IL10 CD40LG AQP1
5 negative regulation of cell proliferation GO:0008285 10.15 TLR2 IL6 IL1B IL10 CXCL8
6 MAPK cascade GO:0000165 10.1 TNF IL2 IL1B IL18 CCL2
7 positive regulation of protein phosphorylation GO:0001934 10.05 TNF IL2 IL1B IFNG F2
8 positive regulation of DNA-binding transcription factor activity GO:0051091 10 TNF IL6 IL1B IL10
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 10 TNF TLR2 IL6 IL1B IL18 CD40LG
10 defense response to Gram-positive bacterium GO:0050830 9.99 TNF TLR2 IL6 CRP
11 positive regulation of gene expression GO:0010628 9.97 TNF TLR2 LCN2 IL6 IL4 IL1B
12 B cell differentiation GO:0030183 9.94 IL4 IL10 CD40LG
13 regulation of insulin secretion GO:0050796 9.93 TNF IL1B IFNG
14 cellular response to hydrogen peroxide GO:0070301 9.93 LCN2 IL6 AQP1
15 cellular response to organic cyclic compound GO:0071407 9.93 TNF IL1B IL18 CCL2
16 response to glucocorticoid GO:0051384 9.92 TNF IL6 IL10
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF IL6 IL18
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.92 TNF TLR2 IL1B IL18
19 humoral immune response GO:0006959 9.92 TNF IL6 IFNG CCL2
20 positive regulation of interleukin-6 production GO:0032755 9.91 TNF TLR2 IL6 IL1B
21 positive regulation of inflammatory response GO:0050729 9.91 TNF TLR2 IL2 IL1B IL18 IFNG
22 cellular response to lipopolysaccharide GO:0071222 9.91 TNF LCN2 IL6 IL1B IL10 CXCL8
23 positive regulation of phagocytosis GO:0050766 9.9 TNF IL1B IFNG
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 TNF IL1B IFNG
25 protein kinase B signaling GO:0043491 9.89 TNF IL1B CCL2
26 acute-phase response GO:0006953 9.89 IL6 F2 CRP
27 positive regulation of T cell proliferation GO:0042102 9.89 IL6 IL4 IL2 IL1B CD40LG
28 positive regulation of cytokine secretion GO:0050715 9.88 TNF IL10 IFNG
29 positive regulation of interferon-gamma production GO:0032729 9.88 TNF IL2 IL1B IL18
30 positive regulation of interleukin-6 secretion GO:2000778 9.88 TNF TLR2 IL1B IFNG
31 positive regulation of interleukin-8 production GO:0032757 9.87 TNF TLR2 IL1B
32 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.87 LCN2 IL4 IL2 IL1B
33 negative regulation of neurogenesis GO:0050768 9.86 TNF IL6 IL1B
34 positive regulation of interleukin-12 production GO:0032735 9.85 TLR2 IFNG CD40LG
35 positive regulation of interleukin-10 production GO:0032733 9.85 TLR2 IL4 CD40LG
36 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10 F2
37 inflammatory response GO:0006954 9.85 TNF TLR2 TLR1 IL6 IL1B IL18
38 positive regulation of chemokine production GO:0032722 9.84 TNF TLR2 IL6
39 positive regulation of glial cell proliferation GO:0060252 9.84 TNF IL6 IL1B
40 microglial cell activation GO:0001774 9.84 TNF TLR2 IL4 IFNG
41 positive regulation of interleukin-8 secretion GO:2000484 9.83 TNF TLR2 TLR1
42 astrocyte activation GO:0048143 9.83 TNF IL1B IFNG
43 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.82 TNF IL1B IFNG
44 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.82 TNF TLR1 IL1B
45 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.81 TNF IL1B IL10
46 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.8 TLR2 IFNG CCL2
47 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR2 IL1B IL18 CCL2
48 response to molecule of bacterial origin GO:0002237 9.78 TLR2 IL10 CXCL8
49 positive regulation of chemokine biosynthetic process GO:0045080 9.78 TNF IL4 IL1B IFNG
50 positive regulation of MHC class II biosynthetic process GO:0045348 9.77 IL4 IL10 IFNG

Molecular functions related to Leptospirosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TNF IL6 IL4 IL2 IL1B IL18
2 growth factor activity GO:0008083 9.35 IL6 IL4 IL2 IL10 F2
3 lipopeptide binding GO:0071723 9.16 TLR2 TLR1

Sources for Leptospirosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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