MCID: LSN001
MIFTS: 31

Lesion of Sciatic Nerve

Categories: Neuronal diseases
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Aliases & Classifications for Lesion of Sciatic Nerve

Summaries for Lesion of Sciatic Nerve

MalaCards based summary: Lesion of Sciatic Nerve, also known as nerve lesion sciatic, is related to neuropathy and sciatic neuropathy. An important gene associated with Lesion of Sciatic Nerve is NGF (Nerve Growth Factor), and among its related pathways/superpathways is Intracellular trafficking proteins involved in CMT neuropathy. Affiliated tissues include spinal cord, smooth muscle and thalamus, and related phenotype is muscle.

Wikipedia: 75 Piriformis syndrome is a condition which is believed to result from compression of the sciatic nerve by... more...

Related Diseases for Lesion of Sciatic Nerve

Diseases related to Lesion of Sciatic Nerve via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 neuropathy 31.0 SH3TC2 PMP22 NGF
2 sciatic neuropathy 30.5 TRPV1 TMEM119 SLN SH3TC2 PMP22 PCDHB16
3 neuropathy, hereditary, with liability to pressure palsies 30.1 SH3TC2 PMP22
4 complex regional pain syndrome 30.1 TRPV1 NGF
5 paine syndrome 29.9 TRPV1 NGF
6 peripheral nervous system disease 29.8 TRPV1 SH3TC2 PMP22 NGF
7 mononeuropathy 29.7 TRPV1 SH3TC2 PMP22 NGF
8 nerve compression syndrome 29.6 TRPV1 SH3TC2 PMP22 NGF
9 foot drop 10.3
10 low compliance bladder 10.2 TRPV1 NGF
11 myofascial pain syndrome 10.2 TRPV1 NGF
12 causalgia 10.2 TRPV1 NGF
13 detrusor sphincter dyssynergia 10.2 TRPV1 NGF
14 acute salpingo-oophoritis 10.2 TRPV1 NGF
15 acute cystitis 10.2 TRPV1 NGF
16 reflex sympathetic dystrophy 10.2 TRPV1 NGF
17 chronic cystitis 10.2 TRPV1 NGF
18 cannabis abuse 10.2 TRPV1 NGF
19 trigeminal nerve disease 10.2 TRPV1 NGF
20 diabetic polyneuropathy 10.2 TRPV1 NGF
21 interstitial cystitis 10.2 TRPV1 NGF
22 burning mouth syndrome 10.2 TRPV1 NGF
23 trigeminal neuralgia 10.2 TRPV1 NGF
24 paresthesia 10.2
25 somatoform disorder 10.2 TRPV1 NGF
26 autonomic nervous system disease 10.1 TRPV1 NGF
27 neurogenic bladder 10.1 TRPV1 NGF
28 paroxysmal extreme pain disorder 10.1 TRPV1 NGF
29 pain agnosia 10.1 TRPV1 NGF
30 agnosia 10.1 TRPV1 NGF
31 radiculopathy 10.1
32 compartment syndrome 10.1
33 erythromelalgia 10.1 TRPV1 NGF
34 spinal stenosis 10.0
35 hereditary sensory neuropathy 10.0 SH3TC2 NGF
36 charcot-marie-tooth disease type x 9.9 SH3TC2 PMP22
37 charcot-marie-tooth disease, demyelinating, type 1f 9.9 SH3TC2 PMP22
38 charcot-marie-tooth disease, demyelinating, type 1c 9.9 SH3TC2 PMP22
39 charcot-marie-tooth disease, demyelinating, type 1b 9.9 SH3TC2 PMP22
40 charcot-marie-tooth disease, type 4b3 9.9 SH3TC2 PMP22
41 charcot-marie-tooth disease, x-linked dominant, 1 9.9 SH3TC2 PMP22
42 charcot-marie-tooth disease, demyelinating, type 1a 9.9 SH3TC2 PMP22
43 demyelinating polyneuropathy 9.9 SH3TC2 PMP22
44 aortic aneurysm, familial abdominal, 1 9.9
45 behcet syndrome 9.9
46 guillain-barre syndrome, familial 9.9
47 klippel-trenaunay-weber syndrome 9.9
48 leiomyoma, uterine 9.9
49 lipomatosis, multiple 9.9
50 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.9

Graphical network of the top 20 diseases related to Lesion of Sciatic Nerve:



Diseases related to Lesion of Sciatic Nerve

Symptoms & Phenotypes for Lesion of Sciatic Nerve

MGI Mouse Phenotypes related to Lesion of Sciatic Nerve:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.02 ANKRD1 NGF PMP22 SH3TC2 SLN

Drugs & Therapeutics for Lesion of Sciatic Nerve

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Physical Therapy as an Adjunct to a Selective Nerve Root Block in the Treatment of Lumbar Radicular Pain From Disk Herniation Completed NCT00934284 Phase 2
2 Prospective, Multi-center, Cohort Study of the Cost Effectiveness of Osteopathic Manipulative Treatment for Chronic Low Back Pain Completed NCT03532230
3 Neuromuscular Ultrasound for Focal Neuropathies Completed NCT01394822

Search NIH Clinical Center for Lesion of Sciatic Nerve

Genetic Tests for Lesion of Sciatic Nerve

Anatomical Context for Lesion of Sciatic Nerve

Organs/tissues related to Lesion of Sciatic Nerve:

MalaCards : Spinal Cord, Smooth Muscle, Thalamus, Breast, Kidney, Bone, Brain

Publications for Lesion of Sciatic Nerve

Articles related to Lesion of Sciatic Nerve:

(show top 50) (show all 216)
# Title Authors PMID Year
1
A Young Man With Acute-Onset Bilateral Arm Weakness After Traumatic Sciatic Neuropathy: A Clinical Vignette. 62
35944082 2022
2
Sciatic neuropathy caused by forced stretching exercise. 62
36239001 2022
3
Open Sciatic Nerve Decompression for Compartment Syndrome after Prolonged Lithotomy Position: A Case Report. 62
36295657 2022
4
Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. 62
36056171 2022
5
A Sciatic Neuralgia Case of an Entrapment Neuropathy Mimicking Piriformis Syndrome Due to Soft Tissue Hemangioma. 62
35980050 2022
6
Peripheral neurological complications during COVID-19: A single center experience. 62
34971857 2022
7
Gluteal compartment syndrome: A systematic review and meta-analysis. 62
34602242 2022
8
Midterm results of titanium conical Wagner stem with challenging femoral anatomy: Survivorship and unique bone remodeling. 62
35158103 2022
9
Peripherally administered cannabinoid receptor 2 (CB2R) agonists lose anti-allodynic effects in TRPV1 knockout mice, while intrathecal administration leads to anti-allodynia and reduced GFAP, CCL2 and TRPV1 expression in the dorsal spinal cord and DRG. 62
34774500 2022
10
Sciatic Neuropathy After Radiation Treatment. 62
34793378 2021
11
Pedicle screws implantation in polymethylmethacrylate construct to stabilise sixth lumbar vertebral body fracture in dogs: 5 cases (2015-2018). 62
34314046 2021
12
The effect of popliteal sciatic nerve block with methylprednisolone in the management of postinjection sciatic neuropathy after clinical and electrophysiological examination. 62
34365781 2021
13
Presumed septic sacroiliitis in a puppy with unilateral hind limb lameness and sciatic nerve neuropathy. 62
33966356 2021
14
Postsurgical Inflammatory Sciatic Neuropathy. 62
34019013 2021
15
COVID-19-Induced Left Sciatic Neuropathy Requiring Prolonged Physical Medicine and Rehabilitation. 62
34306871 2021
16
[Endoscopic sciatic nerve decompression]. 62
34786918 2021
17
Radiofrequency ablation vs microwave ablation for osteoid osteomas: long-term results. 62
32564104 2020
18
The persistent sciatic artery: Report of ten cases. 62
32862980 2020
19
Circumferential Adipose Lesion of the Sciatic Nerve. 62
32407922 2020
20
Reply to the Letter to the Editor for "Use of fluoroscopic-guided transsacral block for the treatment of iatrogenic post-injection sciatic neuropathy: Report of three cases". 62
32760904 2020
21
Ultrasound imaging and guidance in the management of post-injection sciatic neuropathy: Love, loss and space. 62
32760903 2020
22
Tibialis posterior (TP) tendon transfer for foot drop: A single center experience. 62
32405209 2020
23
Pediatric sciatic neuropathy: Clinical presentation and long term follow up. 62
32730417 2020
24
Sciatic neuropathy after normal vaginal delivery: A case report. 62
31822439 2020
25
Sciatic neuropathy in an acromegalic cat without concurrent diabetes mellitus. 62
32128232 2020
26
A case of solitary rectal diverticulum presenting with a large retrorectal abscess. 62
31890199 2020
27
[Treatment of sciatic posttraumatic neuropathy with chronic neuromodulation and endoscopic technics]. 62
33095534 2020
28
Intraneural Ganglion Cyst of the Sciatic Nerve Treated Using Arthroscopic Hip Surgery: A Case Report. 62
30690884 2019
29
Use of fluoroscopic-guided transsacral block for the treatment of iatrogenic post-injection sciatic neuropathy: Report of three cases. 62
31893279 2019
30
Isolated injury to the tibial division of sciatic nerve after self-massage of the gluteal muscle with massage ball: A case report. 62
31083184 2019
31
Targeting the β2-integrin LFA-1, reduces adverse neuroimmune actions in neuropathic susceptibility caused by prenatal alcohol exposure. 62
30961664 2019
32
Clinical and Electrodiagnostic Features Of Nontraumatic Sciatic Neuropathy. 62
30414322 2019
33
Stimulation Contractility Gradient of a Neuromuscular Choristoma Within the Sciatic Nerve: 2-Dimensional Operative Video. 62
29800277 2019
34
MRI of Foot Drop: How We Do It. 62
30152741 2018
35
Bilateral sciatic neuropathy with severe rhabdomyolysis following venlafaxine overdose: A case report. 62
30212953 2018
36
Sciatic neuropathy caused by a pressure ulcer: A case report. 62
30200159 2018
37
A Central Nervous System Tumor Mimicking a Lumbar Spine Pathology Causing Acute Foot Drop: A Case Report. 62
30740383 2018
38
Utility of Magnetic Resonance Imaging for Predicting Severity of Sciatic Nerve Injury. 62
29659424 2018
39
Post-operative extra-spinal etiologies of sciatic nerve impingement. 62
29423723 2018
40
Sciatic neuropathy and rhabdomyolysis after carbon monoxide intoxication: A case report. 62
29879074 2018
41
Sciatic neurosteatosis: Relationship with age, gender, obesity and height. 62
29063256 2018
42
Bilateral Sciatic Neuropathy following Gluteal Augmentation With Autologous Fat Grafting. 62
29707455 2018
43
Gluteal compartment syndrome with neurologic impairment: Report of 2 cases and review of the literature. 62
28224633 2018
44
Segmentation of Peripheral Nerves From Magnetic Resonance Neurography: A Fully-Automatic, Deep Learning-Based Approach. 62
30283397 2018
45
Clinical and Genetic Analysis of an Asian Indian Family with Charcot-Marie-Tooth Disease Type 4C. 62
29515423 2018
46
Prenatal alcohol exposure is a risk factor for adult neuropathic pain via aberrant neuroimmune function. 62
29258553 2017
47
Sciatic neuropathy due to popliteal fossa nerve block. 62
28214338 2017
48
Management of refractory sciatic neuropathic pain using ultrasound-guided pulsed radiofrequency. 62
28946529 2017
49
Synovial cyst of the knee: A rare case of acute sciatic neuropathy. 62
27659236 2017
50
Sciatic neuropathy: findings on magnetic resonance neurography. 62
28670031 2017

Variations for Lesion of Sciatic Nerve

Expression for Lesion of Sciatic Nerve

Search GEO for disease gene expression data for Lesion of Sciatic Nerve.

Pathways for Lesion of Sciatic Nerve

Pathways related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.05 SH3TC2 PMP22

GO Terms for Lesion of Sciatic Nerve

Biological processes related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peripheral nervous system development GO:0007422 9.26 PMP22 NGF
2 cellular response to ATP GO:0071318 8.92 TRPV1 CIB2

Sources for Lesion of Sciatic Nerve

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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