MCID: LSN001
MIFTS: 22

Lesion of Sciatic Nerve

Categories: Neuronal diseases

Aliases & Classifications for Lesion of Sciatic Nerve

MalaCards integrated aliases for Lesion of Sciatic Nerve:

Name: Lesion of Sciatic Nerve 12 15 32
Nerve Lesion Sciatic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:12528
ICD9CM 34 355.0
MeSH 44 D020426
SNOMED-CT 67 52585001
ICD10 32 G57.0
UMLS 71 C0154748

Summaries for Lesion of Sciatic Nerve

MalaCards based summary : Lesion of Sciatic Nerve, also known as nerve lesion sciatic, is related to myofascial pain syndrome and causalgia. An important gene associated with Lesion of Sciatic Nerve is NGF (Nerve Growth Factor), and among its related pathways/superpathways is Trk receptor signaling mediated by PI3K and PLC-gamma. Affiliated tissues include spinal cord and smooth muscle.

Wikipedia : 74 Piriformis syndrome is a condition which is believed to result from compression of the sciatic nerve by... more...

Related Diseases for Lesion of Sciatic Nerve

Diseases related to Lesion of Sciatic Nerve via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 myofascial pain syndrome 10.2 TRPV1 NGF
2 causalgia 10.2 TRPV1 NGF
3 detrusor sphincter dyssynergia 10.2 TRPV1 NGF
4 cough variant asthma 10.2 TRPV1 NGF
5 chronic cystitis 10.2 TRPV1 NGF
6 trigeminal nerve disease 10.2 TRPV1 NGF
7 trigeminal neuralgia 10.1 TRPV1 NGF
8 burning mouth syndrome 10.1 TRPV1 NGF
9 autonomic nervous system disease 10.1 TRPV1 NGF
10 neurogenic bladder 10.1 TRPV1 NGF
11 paroxysmal extreme pain disorder 10.1 TRPV1 NGF
12 somatoform disorder 10.1 TRPV1 NGF
13 pain agnosia 10.1 TRPV1 NGF
14 agnosia 10.1 TRPV1 NGF
15 interstitial cystitis 10.1 TRPV1 NGF
16 charcot-marie-tooth disease type x 10.1 SH3TC2 PMP22
17 paine syndrome 10.1 TRPV1 NGF
18 charcot-marie-tooth disease, type 4b3 10.1 SH3TC2 PMP22
19 charcot-marie-tooth disease, x-linked dominant, 1 10.1 SH3TC2 PMP22
20 charcot-marie-tooth disease, axonal, type 2d 10.0 SH3TC2 PMP22
21 charcot-marie-tooth disease, demyelinating, type 1b 10.0 SH3TC2 PMP22
22 demyelinating polyneuropathy 10.0 PMP22 NGF
23 charcot-marie-tooth disease, demyelinating, type 1c 10.0 SH3TC2 PMP22
24 charcot-marie-tooth disease, demyelinating, type 1a 10.0 SH3TC2 PMP22
25 carpal tunnel syndrome 10.0 SH3TC2 PMP22
26 neuropathy, hereditary, with liability to pressure palsies 9.9 SH3TC2 PMP22
27 polyneuropathy 9.9 SH3TC2 PMP22 NGF
28 tooth disease 9.9 SH3TC2 PMP22 NGF
29 neuroma 9.9 TRPV1 NGF
30 sensory peripheral neuropathy 9.9 TRPV1 PMP22 NGF
31 motor peripheral neuropathy 9.9 SH3TC2 PMP22
32 diabetic neuropathy 9.9 TRPV1 PMP22 NGF
33 hypertrophic neuropathy of dejerine-sottas 9.9 SH3TC2 PMP22
34 irritable bowel syndrome 9.8 TRPV1 NGF
35 charcot-marie-tooth disease, axonal, type 2e 9.8 SH3TC2 PMP22 NGF
36 neuropathy 9.7 TRPV1 SH3TC2 PMP22 NGF
37 mononeuropathy 9.7 TRPV1 SH3TC2 PMP22 NGF
38 nerve compression syndrome 9.7 TRPV1 SH3TC2 PMP22 NGF
39 peripheral nervous system disease 9.7 TRPV1 SH3TC2 PMP22 NGF
40 sciatic neuropathy 8.6 TRPV1 TMEM119 SLN SH3TC2 PMP22 DIRAS1
41 mononeuritis of lower limb 8.2 TRPV1 TMEM119 SP6 SLN SH3TC2 PMP22

Graphical network of the top 20 diseases related to Lesion of Sciatic Nerve:



Diseases related to Lesion of Sciatic Nerve

Symptoms & Phenotypes for Lesion of Sciatic Nerve

Drugs & Therapeutics for Lesion of Sciatic Nerve

Search Clinical Trials , NIH Clinical Center for Lesion of Sciatic Nerve

Genetic Tests for Lesion of Sciatic Nerve

Anatomical Context for Lesion of Sciatic Nerve

MalaCards organs/tissues related to Lesion of Sciatic Nerve:

40
Spinal Cord, Smooth Muscle

Publications for Lesion of Sciatic Nerve

Articles related to Lesion of Sciatic Nerve:

# Title Authors PMID Year
1
Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice. 61
22172934 2012
2
Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. 61
18320028 2008
3
[Effects of electroacupuncture at different frequencies on morphological changes of nervous tissues and electromyogram of skeletal muscles in the rat with injury of sciatic nerve]. 61
16312937 2005
4
Autocrine action of BMP2 regulates expression of GDNF-mRNA in sciatic Schwann cells. 61
14559157 2003
5
Delayed administration of NGF reverses nerve injury induced central alterations of primary afferents. 54
11435919 2001
6
Induction of LIF-mRNA by TGF-beta 1 in Schwann cells. 61
9439810 1997
7
Synergistic increase in nerve growth factor secretion by cultured vascular smooth muscle cells treated with injury-related growth factors. 54
9039650 1997
8
[The effect of different body allowances of aldosterone on serotonin and cAMP metabolism in the tissues of rats with a disordered trophic function of the nervous system]. 61
1339012 1992
9
Immunocomplexes in rat and rabbit spinal cord after injury. 61
3545886 1987
10
Cryoanalgesia. Ultrastructural study on cryolytic lesion of sciatic nerve in rat and rabbit. 61
2823542 1987

Variations for Lesion of Sciatic Nerve

Expression for Lesion of Sciatic Nerve

Search GEO for disease gene expression data for Lesion of Sciatic Nerve.

Pathways for Lesion of Sciatic Nerve

Pathways related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 TRPV1 NGF

GO Terms for Lesion of Sciatic Nerve

Biological processes related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.33 TRPV1 NGF ANKRD1
2 peripheral nervous system development GO:0007422 8.96 PMP22 NGF
3 cellular response to ATP GO:0071318 8.62 TRPV1 CIB2

Molecular functions related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme inhibitor activity GO:0004857 8.62 SLN NGF

Sources for Lesion of Sciatic Nerve

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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