MCID: LSN001
MIFTS: 25

Lesion of Sciatic Nerve

Categories: Neuronal diseases

Aliases & Classifications for Lesion of Sciatic Nerve

MalaCards integrated aliases for Lesion of Sciatic Nerve:

Name: Lesion of Sciatic Nerve 12 15 32
Nerve Lesion Sciatic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:12528
ICD9CM 34 355.0
MeSH 43 D020426
SNOMED-CT 67 367137004
ICD10 32 G57.0
UMLS 71 C0154748

Summaries for Lesion of Sciatic Nerve

MalaCards based summary : Lesion of Sciatic Nerve, also known as nerve lesion sciatic, is related to radiculopathy and tibial nerve palsy. An important gene associated with Lesion of Sciatic Nerve is NGF (Nerve Growth Factor), and among its related pathways/superpathways is Trk receptor signaling mediated by PI3K and PLC-gamma. Affiliated tissues include spinal cord, smooth muscle and skeletal muscle, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Piriformis syndrome is a condition which is believed to result from compression of the sciatic nerve by... more...

Related Diseases for Lesion of Sciatic Nerve

Diseases related to Lesion of Sciatic Nerve via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 10.3 RPL34 PMP22
2 tibial nerve palsy 10.2 RPL34 PMP22
3 plexopathy 10.2 RPL34 PMP22
4 detrusor sphincter dyssynergia 10.2 TRPV1 NGF
5 cough variant asthma 10.2 TRPV1 NGF
6 cauda equina syndrome 10.2 RPL34 PMP22
7 chronic cystitis 10.2 TRPV1 NGF
8 trigeminal nerve disease 10.2 TRPV1 NGF
9 trigeminal neuralgia 10.2 TRPV1 NGF
10 scheuermann disease 10.1 RPL34 PES1
11 charcot-marie-tooth disease, type 4b3 10.1 SH3TC2 PMP22
12 burning mouth syndrome 10.1 TRPV1 NGF
13 tethered spinal cord syndrome 10.1 RPL34 PES1
14 neurogenic bladder 10.1 TRPV1 NGF
15 lumbosacral lipoma 10.1 RPL34 PES1
16 autonomic nervous system disease 10.1 TRPV1 NGF
17 charcot-marie-tooth disease, demyelinating, type 1c 10.1 SH3TC2 PMP22
18 paine syndrome 10.1 TRPV1 NGF
19 peroneal nerve paralysis 10.1 PMP22 PES1
20 asymmetric motor neuropathy 10.1 PMP22 PES1
21 paroxysmal extreme pain disorder 10.1 TRPV1 NGF
22 cataract 38 10.1 NTF4 NGF
23 charcot-marie-tooth disease, demyelinating, type 4f 10.0 SH3TC2 PES1
24 pain agnosia 10.0 TRPV1 RPL34 NGF
25 agnosia 10.0 TRPV1 RPL34 NGF
26 demyelinating polyneuropathy 10.0 PMP22 NGF
27 somatoform disorder 9.9 TRPV1 NGF
28 diabetic neuropathy 9.9 TRPV1 PMP22 NGF
29 polyneuropathy 9.9 SH3TC2 PMP22 NGF
30 bone structure disease 9.9 SH3TC2 RPL34 PES1
31 autosomal dominant distal hereditary motor neuronopathy 9.9 SH3TC2 PES1
32 degenerative disc disease 9.8 TRPV1 RPL34
33 charcot-marie-tooth disease type x 9.8 SH3TC2 PMP22 PES1
34 charcot-marie-tooth disease, x-linked dominant, 1 9.8 SH3TC2 PMP22 PES1
35 charcot-marie-tooth disease, demyelinating, type 1b 9.8 SH3TC2 PMP22 PES1
36 charcot-marie-tooth disease, demyelinating, type 1a 9.8 SH3TC2 PMP22 PES1
37 neuropathy, hereditary, with liability to pressure palsies 9.8 SH3TC2 PMP22 PES1
38 motor peripheral neuropathy 9.8 SH3TC2 PMP22 PES1
39 hypertrophic neuropathy of dejerine-sottas 9.8 SH3TC2 PMP22 PES1
40 charcot-marie-tooth disease and deafness 9.8 SH3TC2 PMP22 PES1
41 polyradiculopathy 9.7 TRPV1 RPL34 PMP22 NGF
42 polyradiculoneuropathy 9.7 RPL34 PMP22
43 neuropathy, congenital hypomyelinating, 1, autosomal recessive 9.7 SH3TC2 PMP22 PES1
44 neuromuscular disease 9.6 SH3TC2 PMP22 PES1
45 charcot-marie-tooth disease, axonal, type 2e 9.6 SH3TC2 PMP22 PES1 NGF
46 nerve compression syndrome 9.3 TRPV1 SH3TC2 PMP22 PES1 NGF
47 sensory peripheral neuropathy 9.3 TRPV1 SH3TC2 PMP22 PES1 NGF
48 charcot-marie-tooth disease 9.2 SH3TC2 PMP22 PES1 NTF4 NGF
49 mononeuropathy 9.1 TRPV1 SH3TC2 RPL34 PMP22 PES1 NGF
50 peripheral nervous system disease 8.6 TRPV1 SH3TC2 RPL34 PMP22 PES1 NTF4

Graphical network of the top 20 diseases related to Lesion of Sciatic Nerve:



Diseases related to Lesion of Sciatic Nerve

Symptoms & Phenotypes for Lesion of Sciatic Nerve

MGI Mouse Phenotypes related to Lesion of Sciatic Nerve:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.56 ANKRD1 CIB2 NGF NTF4 PMP22 SH3TC2
2 homeostasis/metabolism MP:0005376 9.28 ANKRD1 CIB2 NGF NTF4 PES1 PMP22

Drugs & Therapeutics for Lesion of Sciatic Nerve

Search Clinical Trials , NIH Clinical Center for Lesion of Sciatic Nerve

Genetic Tests for Lesion of Sciatic Nerve

Anatomical Context for Lesion of Sciatic Nerve

MalaCards organs/tissues related to Lesion of Sciatic Nerve:

40
Spinal Cord, Smooth Muscle, Skeletal Muscle

Publications for Lesion of Sciatic Nerve

Articles related to Lesion of Sciatic Nerve:

# Title Authors PMID Year
1
Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice. 61
22172934 2012
2
Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. 61
18320028 2008
3
[Effects of electroacupuncture at different frequencies on morphological changes of nervous tissues and electromyogram of skeletal muscles in the rat with injury of sciatic nerve]. 61
16312937 2005
4
Autocrine action of BMP2 regulates expression of GDNF-mRNA in sciatic Schwann cells. 61
14559157 2003
5
Delayed administration of NGF reverses nerve injury induced central alterations of primary afferents. 54
11435919 2001
6
Induction of LIF-mRNA by TGF-beta 1 in Schwann cells. 61
9439810 1997
7
Synergistic increase in nerve growth factor secretion by cultured vascular smooth muscle cells treated with injury-related growth factors. 54
9039650 1997
8
[The effect of different body allowances of aldosterone on serotonin and cAMP metabolism in the tissues of rats with a disordered trophic function of the nervous system]. 61
1339012 1992
9
Immunocomplexes in rat and rabbit spinal cord after injury. 61
3545886 1987
10
Cryoanalgesia. Ultrastructural study on cryolytic lesion of sciatic nerve in rat and rabbit. 61
2823542 1987

Variations for Lesion of Sciatic Nerve

Expression for Lesion of Sciatic Nerve

Search GEO for disease gene expression data for Lesion of Sciatic Nerve.

Pathways for Lesion of Sciatic Nerve

Pathways related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.13 TRPV1 NGF

GO Terms for Lesion of Sciatic Nerve

Biological processes related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuron differentiation GO:0045664 9.37 NTF4 NGF
2 neurotrophin TRK receptor signaling pathway GO:0048011 9.32 NTF4 NGF
3 cellular response to ATP GO:0071318 9.26 TRPV1 CIB2
4 nerve development GO:0021675 9.16 NTF4 NGF
5 nerve growth factor signaling pathway GO:0038180 8.96 NTF4 NGF
6 peripheral nervous system development GO:0007422 8.8 PMP22 NTF4 NGF

Molecular functions related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme inhibitor activity GO:0004857 8.96 SLN NGF
2 nerve growth factor receptor binding GO:0005163 8.62 NTF4 NGF

Sources for Lesion of Sciatic Nerve

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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