Lesion of Sciatic Nerve disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Lesion of Sciatic Nerve

MalaCards integrated aliases for Lesion of Sciatic Nerve:

Name: Lesion of Sciatic Nerve ¹² ¹⁵ ³²

Nerve Lesion Sciatic ⁵⁴

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the nervous system

Nerve, nerve root and plexus disorders

Mononeuropathies of lower limb

Lesion of sciatic nerve

External Ids:

Disease Ontology ¹² DOID:12528

ICD9CM ³⁴ 355.0

MeSH ⁴³ D020426

SNOMED-CT ⁶⁷ 367137004

ICD10 ³² G57.0

UMLS ⁷¹ C0154748

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Summaries for Lesion of Sciatic Nerve

MalaCards based summary : Lesion of Sciatic Nerve, also known as nerve lesion sciatic, is related to radiculopathy and tibial nerve palsy. An important gene associated with Lesion of Sciatic Nerve is NGF (Nerve Growth Factor), and among its related pathways/superpathways is Trk receptor signaling mediated by PI3K and PLC-gamma. Affiliated tissues include spinal cord, smooth muscle and skeletal muscle, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : ⁷⁴ Piriformis syndrome is a condition which is believed to result from compression of the sciatic nerve by... more...

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Related Diseases for Lesion of Sciatic Nerve

Diseases related to Lesion of Sciatic Nerve via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Related Disease	Score	Top Affiliating Genes
1	radiculopathy	10.3	RPL34 PMP22
2	tibial nerve palsy	10.2	RPL34 PMP22
3	plexopathy	10.2	RPL34 PMP22
4	detrusor sphincter dyssynergia	10.2	TRPV1 NGF
5	cough variant asthma	10.2	TRPV1 NGF
6	cauda equina syndrome	10.2	RPL34 PMP22
7	chronic cystitis	10.2	TRPV1 NGF
8	trigeminal nerve disease	10.2	TRPV1 NGF
9	trigeminal neuralgia	10.2	TRPV1 NGF
10	scheuermann disease	10.1	RPL34 PES1
11	charcot-marie-tooth disease, type 4b3	10.1	SH3TC2 PMP22
12	burning mouth syndrome	10.1	TRPV1 NGF
13	tethered spinal cord syndrome	10.1	RPL34 PES1
14	neurogenic bladder	10.1	TRPV1 NGF
15	lumbosacral lipoma	10.1	RPL34 PES1
16	autonomic nervous system disease	10.1	TRPV1 NGF
17	charcot-marie-tooth disease, demyelinating, type 1c	10.1	SH3TC2 PMP22
18	paine syndrome	10.1	TRPV1 NGF
19	peroneal nerve paralysis	10.1	PMP22 PES1
20	asymmetric motor neuropathy	10.1	PMP22 PES1
21	paroxysmal extreme pain disorder	10.1	TRPV1 NGF
22	cataract 38	10.1	NTF4 NGF
23	charcot-marie-tooth disease, demyelinating, type 4f	10.0	SH3TC2 PES1
24	pain agnosia	10.0	TRPV1 RPL34 NGF
25	agnosia	10.0	TRPV1 RPL34 NGF
26	demyelinating polyneuropathy	10.0	PMP22 NGF
27	somatoform disorder	9.9	TRPV1 NGF
28	diabetic neuropathy	9.9	TRPV1 PMP22 NGF
29	polyneuropathy	9.9	SH3TC2 PMP22 NGF
30	bone structure disease	9.9	SH3TC2 RPL34 PES1
31	autosomal dominant distal hereditary motor neuronopathy	9.9	SH3TC2 PES1
32	degenerative disc disease	9.8	TRPV1 RPL34
33	charcot-marie-tooth disease type x	9.8	SH3TC2 PMP22 PES1
34	charcot-marie-tooth disease, x-linked dominant, 1	9.8	SH3TC2 PMP22 PES1
35	charcot-marie-tooth disease, demyelinating, type 1b	9.8	SH3TC2 PMP22 PES1
36	charcot-marie-tooth disease, demyelinating, type 1a	9.8	SH3TC2 PMP22 PES1
37	neuropathy, hereditary, with liability to pressure palsies	9.8	SH3TC2 PMP22 PES1
38	motor peripheral neuropathy	9.8	SH3TC2 PMP22 PES1
39	hypertrophic neuropathy of dejerine-sottas	9.8	SH3TC2 PMP22 PES1
40	charcot-marie-tooth disease and deafness	9.8	SH3TC2 PMP22 PES1
41	polyradiculopathy	9.7	TRPV1 RPL34 PMP22 NGF
42	polyradiculoneuropathy	9.7	RPL34 PMP22
43	neuropathy, congenital hypomyelinating, 1, autosomal recessive	9.7	SH3TC2 PMP22 PES1
44	neuromuscular disease	9.6	SH3TC2 PMP22 PES1
45	charcot-marie-tooth disease, axonal, type 2e	9.6	SH3TC2 PMP22 PES1 NGF
46	nerve compression syndrome	9.3	TRPV1 SH3TC2 PMP22 PES1 NGF
47	sensory peripheral neuropathy	9.3	TRPV1 SH3TC2 PMP22 PES1 NGF
48	charcot-marie-tooth disease	9.2	SH3TC2 PMP22 PES1 NTF4 NGF
49	mononeuropathy	9.1	TRPV1 SH3TC2 RPL34 PMP22 PES1 NGF
50	peripheral nervous system disease	8.6	TRPV1 SH3TC2 RPL34 PMP22 PES1 NTF4

Graphical network of the top 20 diseases related to Lesion of Sciatic Nerve:

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Symptoms & Phenotypes for Lesion of Sciatic Nerve

MGI Mouse Phenotypes related to Lesion of Sciatic Nerve:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.56	ANKRD1 CIB2 NGF NTF4 PMP22 SH3TC2
2	homeostasis/metabolism	MP:0005376	9.28	ANKRD1 CIB2 NGF NTF4 PES1 PMP22

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Drugs & Therapeutics for Lesion of Sciatic Nerve

Search Clinical Trials , NIH Clinical Center for Lesion of Sciatic Nerve

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Genetic Tests for Lesion of Sciatic Nerve

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Anatomical Context for Lesion of Sciatic Nerve

MalaCards organs/tissues related to Lesion of Sciatic Nerve:

⁴⁰

Spinal Cord, Smooth Muscle, Skeletal Muscle

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Publications for Lesion of Sciatic Nerve

Articles related to Lesion of Sciatic Nerve:

#	Title	Authors	PMID	Year
1	Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice. ⁶¹	Wu D...Murashov AK	22172934	2012
2	Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. ⁶¹	Song XY...Zhou XF	18320028	2008
3	[Effects of electroacupuncture at different frequencies on morphological changes of nervous tissues and electromyogram of skeletal muscles in the rat with injury of sciatic nerve]. ⁶¹	Li QW...Wang GJ	16312937	2005
4	Autocrine action of BMP2 regulates expression of GDNF-mRNA in sciatic Schwann cells. ⁶¹	Kinameri E...Matsuoka I	14559157	2003
5	Delayed administration of NGF reverses nerve injury induced central alterations of primary afferents. ⁵⁴	Siri CR...Olivius NP	11435919	2001
6	Induction of LIF-mRNA by TGF-beta 1 in Schwann cells. ⁶¹	Matsuoka I...Kurihara K	9439810	1997
7	Synergistic increase in nerve growth factor secretion by cultured vascular smooth muscle cells treated with injury-related growth factors. ⁵⁴	Creedon DJ...Tuttle JB	9039650	1997
8	[The effect of different body allowances of aldosterone on serotonin and cAMP metabolism in the tissues of rats with a disordered trophic function of the nervous system]. ⁶¹	Azhipa IaI...Egorova LK	1339012	1992
9	Immunocomplexes in rat and rabbit spinal cord after injury. ⁶¹	Palladini G...Guidetti B	3545886	1987
10	Cryoanalgesia. Ultrastructural study on cryolytic lesion of sciatic nerve in rat and rabbit. ⁶¹	Fasano VA...Sguazzi A	2823542	1987

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Genes for Lesion of Sciatic Nerve

Genes related to Lesion of Sciatic Nerve (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	NGF	Nerve Growth Factor	Protein Coding	8.81	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11435919 9039650
2	TMEM119	Transmembrane Protein 119	Protein Coding	5.75	DISEASES inferred ¹⁵
3	RPL34	Ribosomal Protein L34	Protein Coding	5.45	DISEASES inferred ¹⁵
4	CIB2	Calcium And Integrin Binding Family Member 2	Protein Coding	5.35	DISEASES inferred ¹⁵
5	SLN	Sarcolipin	Protein Coding	5.15	DISEASES inferred ¹⁵
6	SH3TC2	SH3 Domain And Tetratricopeptide Repeats 2	Protein Coding	5.14	DISEASES inferred ¹⁵
7	PMP22	Peripheral Myelin Protein 22	Protein Coding	4.99	DISEASES inferred ¹⁵
8	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	4.97	DISEASES inferred ¹⁵
9	ANKRD1	Ankyrin Repeat Domain 1	Protein Coding	4.95	DISEASES inferred ¹⁵
10	NTF4	Neurotrophin 4	Protein Coding	4.88	DISEASES inferred ¹⁵
11	USP6	Ubiquitin Specific Peptidase 6	Protein Coding	4.87	DISEASES inferred ¹⁵
12	PES1	Pescadillo Ribosomal Biogenesis Factor 1	Protein Coding	4.82	DISEASES inferred ¹⁵

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Variations for Lesion of Sciatic Nerve

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Expression for Lesion of Sciatic Nerve

Search GEO for disease gene expression data for Lesion of Sciatic Nerve.

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Pathways for Lesion of Sciatic Nerve

Pathways related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Trk receptor signaling mediated by PI3K and PLC-gamma ¹	10.13	TRPV1 NGF

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GO Terms for Lesion of Sciatic Nerve

Biological processes related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of neuron differentiation	GO:0045664	9.37	NTF4 NGF
2	neurotrophin TRK receptor signaling pathway	GO:0048011	9.32	NTF4 NGF
3	cellular response to ATP	GO:0071318	9.26	TRPV1 CIB2
4	nerve development	GO:0021675	9.16	NTF4 NGF
5	nerve growth factor signaling pathway	GO:0038180	8.96	NTF4 NGF
6	peripheral nervous system development	GO:0007422	8.8	PMP22 NTF4 NGF

Molecular functions related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme inhibitor activity	GO:0004857	8.96	SLN NGF
2	nerve growth factor receptor binding	GO:0005163	8.62	NTF4 NGF

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Sources for Lesion of Sciatic Nerve

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⁷⁴ Wikipedia