MCID: LSN001
MIFTS: 23

Lesion of Sciatic Nerve

Categories: Neuronal diseases

Aliases & Classifications for Lesion of Sciatic Nerve

MalaCards integrated aliases for Lesion of Sciatic Nerve:

Name: Lesion of Sciatic Nerve 12 15
Nerve Lesion Sciatic 55

Classifications:



External Ids:

Disease Ontology 12 DOID:12528
ICD10 33 G57.0 G57.00
ICD9CM 35 355.0
MeSH 44 D020426
UMLS 73 C0154748

Summaries for Lesion of Sciatic Nerve

MalaCards based summary : Lesion of Sciatic Nerve, also known as nerve lesion sciatic, is related to paroxysmal extreme pain disorder and cough variant asthma. An important gene associated with Lesion of Sciatic Nerve is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are DAG and IP3 signaling and Trk receptor signaling mediated by PI3K and PLC-gamma. Related phenotypes are cardiovascular system and integument

Wikipedia : 76 Piriformis syndrome is a condition which is believed to result from compression of the sciatic nerve... more...

Related Diseases for Lesion of Sciatic Nerve

Graphical network of the top 20 diseases related to Lesion of Sciatic Nerve:



Diseases related to Lesion of Sciatic Nerve

Symptoms & Phenotypes for Lesion of Sciatic Nerve

MGI Mouse Phenotypes related to Lesion of Sciatic Nerve:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 LIF NGF SCN10A TRPV1
2 integument MP:0010771 8.92 LIF NGF SCN10A TRPV1

Drugs & Therapeutics for Lesion of Sciatic Nerve

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cost Effectiveness of OMT for Chronic Low Back Pain Not yet recruiting NCT03532230

Search NIH Clinical Center for Lesion of Sciatic Nerve

Genetic Tests for Lesion of Sciatic Nerve

Anatomical Context for Lesion of Sciatic Nerve

Publications for Lesion of Sciatic Nerve

Articles related to Lesion of Sciatic Nerve:

# Title Authors Year
1
Cryoanalgesia. Ultrastructural study on cryolytic lesion of sciatic nerve in rat and rabbit. ( 2823542 )
1987

Variations for Lesion of Sciatic Nerve

Expression for Lesion of Sciatic Nerve

Search GEO for disease gene expression data for Lesion of Sciatic Nerve.

GO Terms for Lesion of Sciatic Nerve

Biological processes related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sensory perception of pain GO:0019233 8.62 SCN10A TRPV1

Molecular functions related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.26 TRPV1 USP6
2 growth factor activity GO:0008083 9.16 LIF NGF
3 ion channel activity GO:0005216 8.96 SCN10A TRPV1
4 cation channel activity GO:0005261 8.62 SCN10A TRPV1

Sources for Lesion of Sciatic Nerve

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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