MCID: LSN001
MIFTS: 26

Lesion of Sciatic Nerve

Categories: Neuronal diseases

Aliases & Classifications for Lesion of Sciatic Nerve

MalaCards integrated aliases for Lesion of Sciatic Nerve:

Name: Lesion of Sciatic Nerve 12 15 32
Nerve Lesion Sciatic 54

Classifications:



External Ids:

Disease Ontology 12 DOID:12528
ICD9CM 34 355.0
MeSH 43 D020426
SNOMED-CT 67 52585001
ICD10 32 G57.0 G57.00
UMLS 71 C0154748

Summaries for Lesion of Sciatic Nerve

MalaCards based summary : Lesion of Sciatic Nerve, also known as nerve lesion sciatic, is related to tibial nerve palsy and plexopathy. An important gene associated with Lesion of Sciatic Nerve is NGF (Nerve Growth Factor), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include spinal cord, smooth muscle and skeletal muscle.

Wikipedia : 74 Piriformis syndrome is a condition which is believed to result from compression of the sciatic nerve... more...

Related Diseases for Lesion of Sciatic Nerve

Diseases related to Lesion of Sciatic Nerve via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 tibial nerve palsy 10.3 RPL34 PMP22
2 plexopathy 10.3 RPL34 PMP22
3 femoral neuropathy 10.2 RPL34 PES1
4 scheuermann disease 10.2 RPL34 PES1
5 lumbosacral lipoma 10.2 RPL34 PES1
6 charcot-marie-tooth disease, demyelinating, type 1c 10.2 SH3TC2 PMP22
7 peroneal nerve paralysis 10.2 PMP22 PES1
8 asymmetric motor neuropathy 10.2 PMP22 PES1
9 tethered spinal cord syndrome 10.2 RPL34 PES1
10 charcot-marie-tooth disease type 2a2a 10.2 SH3TC2 PES1
11 charcot-marie-tooth disease, axonal, type 2j 10.2 SH3TC2 PES1
12 demyelinating polyneuropathy 10.1 PMP22 NGF
13 polyradiculopathy 10.1 RPL34 PMP22 NGF
14 polyradiculoneuropathy 10.1 RPL34 PMP22
15 exostosis 10.1 RPL34 PES1
16 pain agnosia 10.0 RPL34 NGF
17 polyneuropathy 10.0 SH3TC2 PMP22 NGF
18 bone structure disease 10.0 SH3TC2 RPL34 PES1
19 neuropathy, hereditary sensory and autonomic, type iii 10.0 TECPR2 NGF
20 agnosia 10.0 RPL34 NGF
21 charcot-marie-tooth disease, axonal, type 2i 10.0 SH3TC2 PMP22 PES1
22 charcot-marie-tooth disease type x 10.0 SH3TC2 PMP22 PES1
23 charcot-marie-tooth disease, x-linked dominant, 1 10.0 SH3TC2 PMP22 PES1
24 charcot-marie-tooth disease, demyelinating, type 1b 10.0 SH3TC2 PMP22 PES1
25 neuropathy, hereditary, with liability to pressure palsies 10.0 SH3TC2 PMP22 PES1
26 motor peripheral neuropathy 9.9 SH3TC2 PMP22 PES1
27 hypertrophic neuropathy of dejerine-sottas 9.9 SH3TC2 PMP22 PES1
28 charcot-marie-tooth disease and deafness 9.9 SH3TC2 PMP22 PES1
29 ocular dominance 9.9 NTF3 NGF
30 diabetic autonomic neuropathy 9.9 NTF3 NGF
31 diabetic polyneuropathy 9.8 NTF3 NGF
32 hypochondriasis 9.8 NTF4 NTF3
33 neuromuscular disease 9.8 SH3TC2 PMP22 PES1
34 nerve compression syndrome 9.8 SH3TC2 PMP22 PES1 NGF
35 interstitial cystitis 9.7 NTF3 NGF
36 diabetic neuropathy 9.7 PMP22 NTF3 NGF
37 lumbosacral plexus lesion 9.7 NTF4 NTF3 NGF
38 cataract 38 9.7 NTF4 NTF3 NGF
39 secondary progressive multiple sclerosis 9.6 NTF4 NTF3 NGF
40 asperger syndrome 9.6 NTF4 NTF3 NGF
41 demyelinating disease 9.6 PMP22 NTF3 NGF
42 mononeuropathy 9.5 SH3TC2 RPL34 PMP22 PES1 NGF
43 dry eye syndrome 9.4 NTF3 NGF
44 charcot-marie-tooth disease, demyelinating, type 1a 9.4 SH3TC2 PMP22 PES1 NTF3
45 neuropathy, congenital hypomyelinating, 1, autosomal recessive 9.3 SH3TC2 PMP22 PES1 NTF3
46 charcot-marie-tooth disease, axonal, type 2e 9.3 TECPR2 SH3TC2 PMP22 PES1 NGF
47 sensory peripheral neuropathy 9.1 SH3TC2 PMP22 PES1 NTF3 NGF
48 bipolar disorder 9.1 PCNT NTF4 NTF3 NGF
49 charcot-marie-tooth disease 9.1 SH3TC2 PMP22 PES1 NTF3 NGF
50 sciatic neuropathy 8.7 USP6 SH3TC2 RPL34 PMP22 PES1 PCNT

Graphical network of the top 20 diseases related to Lesion of Sciatic Nerve:



Diseases related to Lesion of Sciatic Nerve

Symptoms & Phenotypes for Lesion of Sciatic Nerve

Drugs & Therapeutics for Lesion of Sciatic Nerve

Search Clinical Trials , NIH Clinical Center for Lesion of Sciatic Nerve

Genetic Tests for Lesion of Sciatic Nerve

Anatomical Context for Lesion of Sciatic Nerve

MalaCards organs/tissues related to Lesion of Sciatic Nerve:

40
Spinal Cord, Smooth Muscle, Skeletal Muscle, Eye, Bone

Publications for Lesion of Sciatic Nerve

Articles related to Lesion of Sciatic Nerve:

# Title Authors PMID Year
1
Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice. 61
22172934 2012
2
Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury. 61
18320028 2008
3
[Effects of electroacupuncture at different frequencies on morphological changes of nervous tissues and electromyogram of skeletal muscles in the rat with injury of sciatic nerve]. 61
16312937 2005
4
Autocrine action of BMP2 regulates expression of GDNF-mRNA in sciatic Schwann cells. 61
14559157 2003
5
Delayed administration of NGF reverses nerve injury induced central alterations of primary afferents. 54
11435919 2001
6
Induction of LIF-mRNA by TGF-beta 1 in Schwann cells. 61
9439810 1997
7
Synergistic increase in nerve growth factor secretion by cultured vascular smooth muscle cells treated with injury-related growth factors. 54
9039650 1997
8
[The effect of different body allowances of aldosterone on serotonin and cAMP metabolism in the tissues of rats with a disordered trophic function of the nervous system]. 61
1339012 1992
9
Immunocomplexes in rat and rabbit spinal cord after injury. 61
3545886 1987
10
Cryoanalgesia. Ultrastructural study on cryolytic lesion of sciatic nerve in rat and rabbit. 61
2823542 1987

Variations for Lesion of Sciatic Nerve

Expression for Lesion of Sciatic Nerve

Search GEO for disease gene expression data for Lesion of Sciatic Nerve.

Pathways for Lesion of Sciatic Nerve

Pathways related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 NTF4 NTF3 NGF
2 11.23 NTF4 NTF3 NGF
3
Show member pathways
10.95 NTF4 NTF3 NGF
4 10.91 NTF3 NGF
5
Show member pathways
10.58 NTF4 NTF3 NGF

GO Terms for Lesion of Sciatic Nerve

Cellular components related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic vesicle GO:0031410 9.26 SH3TC2 NTF4 NTF3 NGF
2 synaptic vesicle GO:0008021 8.8 NTF4 NTF3 NGF

Biological processes related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.63 NTF4 NTF3 NGF
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.61 NTF4 NTF3 NGF
3 memory GO:0007613 9.58 NTF4 NTF3 NGF
4 modulation of chemical synaptic transmission GO:0050804 9.54 NTF4 NTF3 NGF
5 neuron projection morphogenesis GO:0048812 9.5 NTF4 NTF3 NGF
6 neurotrophin TRK receptor signaling pathway GO:0048011 9.48 NTF4 NGF
7 regulation of neuron differentiation GO:0045664 9.43 NTF4 NTF3 NGF
8 nerve development GO:0021675 9.33 NTF4 NTF3 NGF
9 nerve growth factor signaling pathway GO:0038180 9.13 NTF4 NTF3 NGF
10 peripheral nervous system development GO:0007422 8.92 PMP22 NTF4 NTF3 NGF

Molecular functions related to Lesion of Sciatic Nerve according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.8 NTF4 NTF3 NGF

Sources for Lesion of Sciatic Nerve

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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