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MCID: LTH001
MIFTS: 30

Lethal Midline Granuloma

Categories: Cancer diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Lethal Midline Granuloma

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MalaCards integrated aliases for Lethal Midline Granuloma:

Name: Lethal Midline Granuloma 12 15 17 32
Granuloma, Lethal Midline 44 71
Midfacial Necrotising Lesion 12
Malignant Granuloma of Face 12
Midline Lethal Granuloma 20

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9072
ICD9CM 34 446.3
MeSH 44 D006103
NCIt 50 C8196
SNOMED-CT 67 58961005
ICD10 32 M31.2
UMLS 71 C0018197
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Summaries for Lethal Midline Granuloma

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MalaCards based summary : Lethal Midline Granuloma, also known as granuloma, lethal midline, is related to fibrosarcoma of bone and lymphomatoid granulomatosis. An important gene associated with Lethal Midline Granuloma is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and NF-kappaB Signaling. Affiliated tissues include skin and kidney.

Wikipedia : 74 Lethal midline granuloma (LMG) is an historical term for a condition in which necrotic and highly... more...

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Related Diseases for Lethal Midline Granuloma

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Diseases related to Lethal Midline Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 fibrosarcoma of bone 30.8 TNFRSF8 SERPINA3
2 lymphomatoid granulomatosis 30.5 TIA1 GZMB
3 lymphoproliferative syndrome 30.0 TNFRSF8 TIA1 PRF1
4 lymphomatoid papulosis 29.9 TNFRSF8 TIA1 GZMB
5 peripheral t-cell lymphoma 29.8 TNFRSF8 TIA1 NCAM1 GZMB
6 lymphoma, hodgkin, classic 29.8 TNFRSF8 TIA1 GZMB
7 panniculitis 29.5 TNFRSF8 TIA1 NCAM1 GZMB
8 lymphoma 29.4 TNFRSF8 TIA1 PRF1 GZMB
9 mature t-cell and nk-cell lymphoma 29.2 TNFRSF8 TIA1 NCAM1 GZMB CD7 CD2
10 thrombocytopenia 29.0 TNFRSF8 PRF1 ICAM1 GZMB
11 lymphoma, non-hodgkin, familial 28.0 TNFRSF8 SPN SERPINA3 PRF1 NCAM1 GZMB
12 nasal type extranodal nk/t-cell lymphoma 11.5
13 polymorphic reticulosis 10.6
14 histiocytosis 10.4
15 testicular malignant germ cell cancer 10.3 TNFRSF8 SERPINA3
16 histiocytic and dendritic cell cancer 10.2 TNFRSF8 SERPINA3
17 reticulum cell sarcoma 10.2 TNFRSF8 CD2
18 cutaneous solitary mastocytoma 10.2 SERPINA3 CD2
19 actinic prurigo 10.2 ICAM1 CD2
20 orbital cellulitis 10.2 TNFRSF8 NCAM1
21 acute orbital inflammation 10.2 TNFRSF8 NCAM1
22 indolent systemic mastocytosis 10.2 TNFRSF8 CD2
23 pityriasis lichenoides 10.2 TNFRSF8 CD7
24 pityriasis lichenoides et varioliformis acuta 10.2 TNFRSF8 CD7
25 hodgkin's lymphoma, mixed cellularity 10.2 TNFRSF8 SPN
26 lung lymphoma 10.2 TNFRSF8 SPN
27 mediastinal cancer 10.2 TNFRSF8 NCAM1
28 bone lymphoma 10.2 TNFRSF8 SPN
29 rhinitis 10.1
30 orbit lymphoma 10.1 TIA1 NCAM1
31 tracheal lymphoma 10.1 TNFRSF8 SPN
32 henoch-schoenlein purpura 10.1 SERPINA3 ICAM1
33 nasal cavity benign neoplasm 10.1 NCAM1 CD2
34 pancreatic endocrine carcinoma 10.1 SERPINA3 NCAM1
35 inflammatory bowel disease 16 10.1 CD7 CD2
36 rhinosporidiosis 10.1 TIA1 NCAM1
37 breast osteosarcoma 10.1 SPN CD2
38 parasitic ichthyosporea infectious disease 10.1 TIA1 NCAM1
39 chronic nk-cell lymphocytosis 10.1 NCAM1 CD7
40 primary cutaneous anaplastic large cell lymphoma 10.0 TIA1 GZMB
41 lichen sclerosus et atrophicus 10.0 TIA1 GZMB
42 lepromatous leprosy 10.0 ICAM1 CD2
43 lymphocytic gastritis 10.0 TIA1 GZMB
44 vein disease 10.0 SERPINA3 ICAM1
45 autoimmune glomerulonephritis 10.0 ICAM1 GZMB
46 autoimmune disease 10.0
47 immune deficiency disease 10.0
48 granulomatosis with polyangiitis 10.0
49 potocki-lupski syndrome 10.0
50 necrotizing sialometaplasia 10.0

Graphical network of the top 20 diseases related to Lethal Midline Granuloma:



Diseases related to Lethal Midline Granuloma
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Symptoms & Phenotypes for Lethal Midline Granuloma

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Drugs & Therapeutics for Lethal Midline Granuloma

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Search Clinical Trials , NIH Clinical Center for Lethal Midline Granuloma

Cochrane evidence based reviews: granuloma, lethal midline

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Genetic Tests for Lethal Midline Granuloma

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Anatomical Context for Lethal Midline Granuloma

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MalaCards organs/tissues related to Lethal Midline Granuloma:

40
Skin, Kidney
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Publications for Lethal Midline Granuloma

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Articles related to Lethal Midline Granuloma:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Lethal Midline Granuloma: An Enigma in Diagnosis-A Rare Case Report. 61
31763310 2019
2
High grade cutaneous B-cell lymphoma presenting as lethal midline granuloma - case report of an unusual presentation. 61
30938452 2019
3
Extranodal NK/T-Cell Lymphoma, Nasal Type, Presenting as Refractory Pseudomonas aeruginosa Facial Cellulitis. 61
28748192 2017
4
Nasal NK/T Cell Lymphoma Presenting with Perforation of Palate: A Case Report and Review of Literature. 61
28511419 2017
5
Lethal midline granuloma. 61
23440011 2013
6
Mucor irregularis infection and lethal midline granuloma: a case report and review of published literature. 61
22744721 2012
7
Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review. 61
21336457 2011
8
[Laryngotracheal NK/T lymphoma: clinical case]. 61
20307871 2011
9
Angiocentric nasal T-cell lymphoma in a patient withidiopathic CD4+ lymphocytopenia. 61
20404393 2009
10
Nasal NK/T cell lymphoma presenting as a lethal midline granuloma. 61
18388376 2008
11
[Primary nasal natural killer/T-cell lymphomas: classification and clinicopathological features]. 61
17103008 2007
12
[Report on the 34th meeting of the German Clinical Immunology Workgroup, Frankfurt, 03.-04.11.2006]. 61
17160656 2007
13
Lethal midline granuloma: a case of T-cell lymphoma. 61
18043881 2007
14
Extranodal NK/T-cell lymphoma, nasal type. 61
17064952 2007
15
Prosthetic rehabilitation of a midfacial defect resulting from lethal midline granuloma--a clinical report. 61
17002746 2006
16
[Case series of localized nasal NK/T-cell lymphoma treated with preceding intensified local radiation therapy before systemic chemotherapy]. 61
16685174 2006
17
Lethal midline granuloma-nasal natural killer/T-cell lymphoma. 61
16601443 2006
18
Body cavity-based presentation of natural killer cell lymphoma. 61
15621817 2005
19
Clinicopathologic study of non-Hodgkin lymphoma in sinonasal and hard palate regions in 15 Japanese cases. 61
15735372 2005
20
[Lethal midline granuloma]. 61
15628680 2004
21
Nasal and nasal-type natural killer (NK)/T-cell lymphoma: immunophenotype and Epstein-Barr virus (EBV) association. 61
14569739 2003
22
Centrofacial malignant T-cell lymphoma exhibiting recurrent fever and skin ulcer in a 3-year-old girl. 61
12487833 2002
23
Vision-threatening complications of nasal T/NK lymphoma. 61
12208253 2002
24
Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. 61
11904341 2002
25
Lethal midline granuloma in a human immunodeficiency virus-infected patient. 61
11545099 2001
26
[Angiocentric T/NK cell lymphoma: a special clinical-pathological entity of lethal midline granuloma. A case report]. 61
11488153 2001
27
Nasal natural killer cell lymphoma presenting as lethal midline granuloma. 61
11168665 2000
28
[Reactive hemaphagocytic syndrome in a patient with midline NK-cell lymphoma]. 61
11139660 2000
29
Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and Japan. 61
10811105 2000
30
Midline destructive lesions of the sinonasal tract: simplified terminology based on histopathologic criteria. 61
10696019 2000
31
Lethal midline granuloma: report of three cases. 61
10835805 2000
32
[Diagnostic difficulties in nasopharyngeal tumors]. 61
10822970 2000
33
Lethal midline granuloma starting as granuloma laryngis. 61
10778778 2000
34
[Nasal T-cell lymphoma of the lethal midline type. Case report and current aspects in the literature]. 61
10412659 1999
35
Lethal midline granuloma revisited: nasal T/Natural-killer cell lymphoma. 61
10561195 1999
36
[Lethal midline granuloma: clinical management of three cases]. 61
10413926 1999
37
Sinonasal malignant lymphomas: a distinct clinicopathological category. 61
10214792 1999
38
Chronological changes in incidences of polymorphic reticulosis in Korea and Japan. 61
10202275 1999
39
[Nasal T-cell lymphoma as a differential diagnosis of the midline granuloma syndrome]. 61
10226981 1999
40
[Intracranial and orbital extension of a nasal cavity adult T-cell leukemia: a case report]. 61
10024985 1999
41
Sinonasal lymphoma presenting as a lethal midline granuloma: case report. 61
9590351 1998
42
Treatment of localized non-Hodgkin's lymphomas of the head and neck: focusing on cases of non-lethal midline granuloma. 61
9727875 1998
43
Angiocentric T-cell lymphoma presenting as lethal midline granuloma. 61
9248885 1997
44
[Clinical characteristics of Epstein-Barr virus-associated natural killer cell lymphoma/leukemia]. 61
9046835 1997
45
Treatment of lethal midline granuloma type nasal T-cell lymphoma. 61
9208902 1997
46
Circulating intercellular adhesion molecule-1 and its cellular expression in head and neck non-Hodgkin's lymphomas, including lethal midline granuloma. 61
8712635 1996
47
Midline granuloma presenting as orbital cellulitis. 61
8720685 1996
48
[Two cases of lethal midline granuloma thought to be of natural killer cell origin]. 61
8822254 1996
49
Experience of radiotherapy in lethal midline granuloma with special emphasis on centrofacial T-cell lymphoma: a retrospective analysis covering a 34-year period. 61
8850419 1996
50
Patient-administered sphenopalatine ganglion block. 61
8826027 1996
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Variations for Lethal Midline Granuloma

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Expression for Lethal Midline Granuloma

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Search GEO for disease gene expression data for Lethal Midline Granuloma.
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Pathways for Lethal Midline Granuloma

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Pathways related to Lethal Midline Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 11.97 PRF1 ICAM1 GZMB
2
NF-kappaB Signaling 4
11.97 TNFRSF8 NCAM1 GZMB CD2
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.5 SPN NCAM1 CD2
4
Cell adhesion molecules 36
11.1 SPN NCAM1 ICAM1 CD2
5
Innate Lymphoid Cell Differentiation Pathways 64
11.03 NCAM1 GZMB CD7
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GO Terms for Lethal Midline Granuloma

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Cellular components related to Lethal Midline Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 SPN NCAM1 ICAM1 CD2
2 immunological synapse GO:0001772 9.16 ICAM1 GZMB
3 external side of plasma membrane GO:0009897 8.92 SPN NCAM1 ICAM1 CD2

Biological processes related to Lethal Midline Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.56 TIA1 PRF1 GZMB CD2
2 leukocyte migration GO:0050900 9.33 SPN ICAM1 CD2
3 T cell activation GO:0042110 9.32 CD7 CD2
4 cytolysis GO:0019835 8.96 PRF1 GZMB
5 positive regulation of tumor necrosis factor production GO:0032760 8.8 TNFRSF8 SPN CD2

Molecular functions related to Lethal Midline Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.13 TNFRSF8 SPN ICAM1
2 signaling receptor activity GO:0038023 8.8 ICAM1 CD7 CD2
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Sources for Lethal Midline Granuloma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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