MCID: LKM002
MIFTS: 69

Leukemia

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Leukemia

Summaries for Leukemia

MedlinePlus : 43 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. There are different types of leukemia, including Acute lymphocytic leukemia Acute myeloid leukemia Chronic lymphocytic leukemia Chronic myeloid leukemia Leukemia can develop quickly or slowly. Chronic leukemia grows slowly. In acute leukemia, the cells are very abnormal and their number increases rapidly. Adults can get either type; children with leukemia most often have an acute type. Some leukemias can often be cured. Other types are hard to cure, but you can often control them. Treatments may include chemotherapy, radiation and stem cell transplantation. Even if symptoms disappear, you might need therapy to prevent a relapse. NIH: National Cancer Institute

MalaCards based summary : Leukemia, also known as leukemias, is related to myeloid leukemia and acute leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Leukemia is MIR27A (MicroRNA 27a), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Acitretin and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, t cells and b cells, and related phenotypes are Increased HDAC inhibitor resistance and cellular

Disease Ontology : 12 A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

Wikipedia : 75 Leukemia, also spelled leukaemia, is a group of blood cancers that usually begin in the bone marrow and... more...

Related Diseases for Leukemia

Diseases in the Leukemia family:

Chronic Leukemia Acute Leukemia
Subacute Leukemia

Diseases related to Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2732)
# Related Disease Score Top Affiliating Genes
1 myeloid leukemia 35.4 RUNX1 NPM1 LIF FLT3 ETV6 CEBPA
2 acute leukemia 35.4 RUNX1 FLT3 ETV6 CEBPA
3 childhood leukemia 35.3 RUNX1 PBX1 ETV6 ABL1
4 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 35.3 RUNX1 FLT3 ETV6
5 leukemia, acute lymphoblastic 35.2 RUNX1 MIR27A FLT3 ETV6 BCR ABL1
6 cytogenetically normal acute myeloid leukemia 35.2 NPM1 FLT3 CEBPA
7 core binding factor acute myeloid leukemia 35.2 RUNX1 FLT3 CEBPA
8 acute myeloblastic leukemia without maturation 35.2 NPM1 FLT3
9 acute myeloblastic leukemia with maturation 35.1 NPM1 FLT3
10 chronic myelomonocytic leukemia 35.0 RUNX1 FLT3 ETV6
11 leukemia, acute lymphoblastic 3 34.9 RUNX1 PBX1 FLT3 ETV6 BCR ABL1
12 b-cell childhood acute lymphoblastic leukemia 34.9 RUNX1 ETV6
13 precursor t-cell acute lymphoblastic leukemia 34.9 TCL1A FLT3 ETV6 BCR ABL1
14 leukemia, chronic myeloid 34.8 RUNX1 HOTAIR FLT3 ETV6 BCR ABL1
15 aleukemic leukemia cutis 34.7 RUNX1 NPM1 FLT3
16 acute myeloid leukemia with t(8;21)(q22;q22) translocation 34.6 RUNX1 FLT3 CEBPA
17 lymphocytic leukemia 34.6 RUNX1 HOTAIR ETV6 BCR
18 b-cell adult acute lymphocytic leukemia 34.5 PBX1 ABL1
19 philadelphia-negative chronic myeloid leukemia 34.5 BCR ABL1
20 acute promyelocytic leukemia 34.2 RUNX1 PML NPM1 NEAT1 HOTAIRM1 FLT3
21 8p11 myeloproliferative syndrome 34.2 RUNX1 FLT3 BCR
22 myelodysplastic syndrome 34.1 RUNX1 NPM1 FLT3 ETV6 CEBPA ABL1
23 platelet disorder, familial, with associated myeloid malignancy 33.6 RUNX1 ETV6
24 hematologic cancer 32.1 RUNX1 NPM1 FLT3 ETV6 BCR ABL1
25 leukemia, acute myeloid 31.8 RUNX1 PML NPM1 MIR331 MIR27A HOTAIRM1
26 bone marrow cancer 31.1 RUNX1 FLT3 ETV6 BCR ABL1
27 cerebral meningioma 29.9 LIFR LIF
28 kidney cancer 29.1 MIR27A HOTAIR GAS5
29 thyroid cancer, nonmedullary, 1 29.0 NEAT1 HOTAIR GAS5
30 osteogenic sarcoma 28.7 NEAT1 HOTAIR GAS5 CDKN2B-AS1
31 oral squamous cell carcinoma 28.6 NEAT1 MIR331 MIR27A HOTAIR
32 glioma 28.5 NEAT1 HOTAIR GAS5 CDKN2B-AS1
33 malignant glioma 28.0 NEAT1 HOTAIR GAS5 CDKN2B-AS1
34 laryngeal squamous cell carcinoma 27.8 NEAT1 HOTAIR CDKN2B-AS1
35 ovarian cancer 27.8 NEAT1 MIR331 HOTAIR GAS5 CDKN2B-AS1 ABL1
36 nasopharyngeal carcinoma 27.8 NEAT1 HOTAIR GAS5 CDKN2B-AS1
37 melanoma 27.3 MIR331 MIR27A HOTAIRM1 HOTAIR GAS5 CDKN2B-AS1
38 leukemia, chronic lymphocytic 12.8
39 hairy cell leukemia 12.7
40 juvenile myelomonocytic leukemia 12.6
41 adult t-cell leukemia 12.6
42 megakaryocytic leukemia 12.6
43 leukemia, acute monocytic 12.6
44 t-cell prolymphocytic leukemia 12.6
45 acute t cell leukemia 12.6
46 acute monoblastic leukemia 12.5
47 childhood acute lymphocytic leukemia 12.5
48 prolymphocytic leukemia 12.5
49 familial acute myeloid leukemia with mutated cebpa 12.5
50 plasma cell leukemia 12.5

Comorbidity relations with Leukemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Leukemia, Chronic Lymphocytic

Graphical network of the top 20 diseases related to Leukemia:



Diseases related to Leukemia

Symptoms & Phenotypes for Leukemia

UMLS symptoms related to Leukemia:


angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HDAC inhibitor resistance GR00115-A-0 8.62 LIF LIFR

MGI Mouse Phenotypes related to Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 ABL1 BCR CEBPA ETV6 FLT3 LIF
2 hematopoietic system MP:0005397 10.15 ABL1 BCR CEBPA ETV6 FLT3 LIF
3 growth/size/body region MP:0005378 10.14 ABL1 BCR CEBPA ETV6 FLT3 LIF
4 endocrine/exocrine gland MP:0005379 10.13 ABL1 CEBPA ETV6 FLT3 LIF LIFR
5 immune system MP:0005387 10.1 ABL1 BCR CEBPA ETV6 FLT3 LIF
6 embryo MP:0005380 10.06 ABL1 ETV6 LIF LIFR NPM1 PBX1
7 mortality/aging MP:0010768 9.93 ABL1 BCR CEBPA ETV6 FLT3 LIF
8 liver/biliary system MP:0005370 9.91 ABL1 BCR CEBPA LIF LIFR NPM1
9 neoplasm MP:0002006 9.5 CEBPA ETV6 FLT3 NPM1 PML RAF1
10 normal MP:0002873 9.23 ABL1 BCR CEBPA ETV6 PBX1 PML

Drugs & Therapeutics for Leukemia

Drugs for Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 926)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acitretin Approved Phase 4 55079-83-9, 69427-46-9 6437841
2
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
3
Ethanol Approved Phase 4 64-17-5 702
4
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
5
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
6
Valganciclovir Approved, Investigational Phase 4 175865-60-8 64147
7
Fosaprepitant Approved Phase 4 172673-20-0 219090
8
Aprepitant Approved, Investigational Phase 4 170729-80-3 151165 6918365
9
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
10
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
11
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
12
Bupropion Approved Phase 4 34841-39-9, 34911-55-2 444
13
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
14
Nitric Oxide Approved Phase 4 10102-43-9 145068
15
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
16
Tobramycin Approved, Investigational Phase 4 32986-56-4 36294 5496
17
Morphine Approved, Investigational Phase 4 57-27-2 5288826
18
Metformin Approved Phase 4 657-24-9 4091 14219
19
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
20
Nicotine Approved Phase 4 54-11-5 942 89594
21
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
22
Prilocaine Approved Phase 4 721-50-6 4906
23
Radium Ra 223 dichloride Approved, Investigational Phase 4 444811-40-9
24
Teniposide Approved Phase 4 29767-20-2 34698
25
Ofloxacin Approved Phase 4 82419-36-1 4583
26
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
27
Ixazomib Approved, Investigational Phase 4 1072833-77-2
28 Daratumumab Approved Phase 4 945721-28-8
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
30
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
31
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
32
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
33
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
34
Chlorambucil Approved Phase 4 305-03-3 2708
35
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
36
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
37
Zidovudine Approved Phase 4 30516-87-1 35370
38
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
39
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
40
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
41
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 6433735 5283731
42 Molgramostim Investigational Phase 4 99283-10-0
43
Aclarubicin Investigational Phase 4 57576-44-0 451415
44 Antibodies Phase 4
45 Immunoglobulins Phase 4
46 Vaccines Phase 4
47 Antibodies, Blocking Phase 4
48
Ethylene Phase 4 74-85-1 6325
49 Antidepressive Agents Phase 4
50 Serotonin Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 6702)
# Name Status NCT ID Phase Drugs
1 Treatment Plan for Hematologic Malignancies Using Intravenous Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide to Examine Results, Success and Side Effects of Treatment With Chemotherapy Only, as a Preparative Therapy for Patients With Cord Blood Transplants Unknown status NCT01339988 Phase 4 Busulfan/Cyclophosphamide
2 ASSESSMENT OF GH-IGF1 AXIS AND TO STUDY RESPONSE TO GH THERAPY IN CHILDREN WITH CML IN REMISSION HAVING GH DEFICIENCY Unknown status NCT01901666 Phase 4 Growth Hormone
3 Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemia Unknown status NCT02317159 Phase 4 Imatinib
4 Multicenter Study To Optimize Treatment in Elderly Patients (> 55 Years, No Upper Age Limit) With Acute Lymphoblastic Leukemia (GMALL Elderly 1/2003)(Amend 2) Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5 Interferon for the Intervention of Molecular Relapse in t (8; 21) AML After Allo-HSCT Unknown status NCT02027064 Phase 4 Interferon-alpha
6 Multicenter, PhaseⅣ, Open Label Trial of Nilotinib in Adult Patients Diagnosed Philadelphia Chromosome Positive(Ph+) Chronic Myeloid Leukemia in CP/AP Intolerant to Dasatinib Unknown status NCT02389920 Phase 4 Nilotinib
7 Low-dose Dasatinib as First-line Treatment for Chronic Myeloid Leukemia Unknown status NCT03216070 Phase 4 Dasatinib 50 MG
8 A Randomized Comparison of Fludarabine in Combination With Cytarabine Versus High -Dose Cytarabine in Post-remission Therapy for AML1-ETO Acute Myeloid Leukemia Unknown status NCT02024308 Phase 4 Fludarabine;Cytarabine
9 Philadelphia -Negative High-risk Children Acute Lymphoblastic Leukemia(ALL) Treatment:Induction Therapy:Vincristine(V),Idarubicin(I),L-asparaginase(L),Dexamethasone(D);Consolidation:V+Daunorubicin(D)+L+D, Methotrexate,Cytarabine Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
10 German Multicenter Study for Treatment Optimisation in Acute Lymphoblastic Leukemia in Adults and Adolescents Above 15 Years (Amend 3) (GMALL 07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
11 AIDA2000 - Risk-Adapted Therapy for Patients With Acute Promyelocytic Leukemia(APL) Unknown status NCT00180128 Phase 4 all-trans retinoid acid;idarubicin;mitoxantrone;daunorubicin;cytarabine
12 A Multicenter, Open-Label Study of Nipent, Cytoxan and Rituxan in Patients With Previously Untreated or Treated Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
13 Treatment of Elderly Patients (>60 Years) With Acute Myeloblastic Leukemia or Advanced MDS (RAEB-T): An Open Randomized Study to Test the Efficacy of G-CSF-Priming and a Feasibility Trial of Dose-Reduced Allogeneic Transplantation and of Autologous Stem Cell Transplantation Unknown status NCT00199147 Phase 4 Cytarabine;Etoposide;Idarubicin;G-CSF;Fludarabine
14 CRESCENDO (Compliance: Role Emerges for Success in CML: Evaluation aND Optimisation): A Prospective, Multi-center, Phase IV Study to Assess the Compliance in Patients With Philadelphia Chromosome-positive (Ph+) and/or BCR-ABL Positive Chronic Myelogenous Leukaemia (CML) Under Long-term Imatinib Therapy Unknown status NCT01243489 Phase 4
15 PEG-asparaginase During Two Treatment Courses in the Treatment of Childhood Acute Lymphoblastic Leukemia Unknown status NCT00192673 Phase 4 PEG-asparaginase
16 Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia Before Allogeneic Hematopoietic Cell Transplantation Unknown status NCT01806116 Phase 4 decitabine
17 Multicenter Randomised Clinical Trial in Acute Myeloid Leukemia Treatment Based on Three Anthracyclines, Comparing Two Types of Consolidation With Different ARA-C Doses Followed by One Year Maintenance Unknown status NCT01587430 Phase 4 high dose ARA-C;standard dose ARA-C
18 Optimization of the Primary Therapy for Patients With Hodgkin's Lymphoma and Evaluation of the Positron Emission Tomography (PET) as a Diagnostic Tool for Primary Staging and Assessment of the Effects of the Therapy Unknown status NCT00188149 Phase 4 Combined chemotherapy (ABVD, BACOPP-D)
19 Ma-Spore ALL 2010 Study Unknown status NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
20 The Combination of Lower Dosage of Chemotherapy With Tyrosine Kinase Inhibitor to Treat Newly Diagnosed ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
21 Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
22 Clinical Study of GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia in Guangdong Province Unknown status NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
23 An Open-label,Multi-center,Prospective Study of Idarubicin and Etoposide Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
24 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
25 A Phase IV, Randomized Study to Evaluate the Safety and Efficacy of Idarubicin at Different Dosages Combined With Cytarabine as Induction Therapy for Newly Diagnosed Acute Myeloid Leukaemia Unknown status NCT02277847 Phase 4 Idarubicin(8mg/m2) and cytosine arabinoside;Idarubicin(10mg/m2), cytosine arabinoside
26 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
27 Treatment of Relapsed Acute Promyelocytic Leukemia With Arsenic Trioxide (Phase IV Study) Unknown status NCT00196768 Phase 4 Arsenic trioxide;Trisenox
28 Evaluation of the Immune Response After Vaccination Against Hepatitis B in Patients With Indolent Lymphoproliferative Disorders With no Treatment. Unknown status NCT01698866 Phase 4
29 An Open Label Trial to Show That Subjects With Severe Plaque-Type Psoriasis Receiving Acitretin 25 mg/Day And Stabilized On A Photochemotherapy Regimen Who Are Experiencing Retinoid-Related Adverse Events, Benefit From A Reduction In Acitretin Dose to 17.5 mg/Day, While Maintaining Comparable Efficacy Along With Improved Tolerability Unknown status NCT01228409 Phase 4 Acitretin 17.5 mg/day
30 A Phase 4, Randomized, Open-Label Study to Assess Humoral and Intestinal Polio Immunity Following a Three-Dose Trivalent Inactivated Polio Vaccine Schedule Relative to Two Sequential Schedules of IPV/Bivalent Oral Polio Vaccines Unknown status NCT01841671 Phase 4
31 1-Year Longitudinal Follow-up Study of Serologic Responses to 7-valent Pneumococcal Conjugated Vaccination and Opsonophagocytic Activities for Streptococcus Pneumoniae Among Patients With Human Immunodeficiency Virus Infection Unknown status NCT00885625 Phase 4
32 An Open-label, Multicenter Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Completed NCT00786812 Phase 4 Nilotinib
33 Study Comparing Standard Dose and High-dose Imatinib Mesylate in Patients With Chronic Phase Ph+ CML Completed NCT00171899 Phase 4 imatinib mesylate
34 A Multi-center, Open-label, Exploratory Study of Bcr-Abl Kinetics in Adult Patients on Nilotinib With Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) and a Suboptimal Molecular Response to Imatinib Completed NCT00644878 Phase 4 Nilotinib
35 Pilot Study for Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
36 A Phase IV Study of Corticosteroids As Prophylaxis for Infusion-Related Adverse Events to Mylotarg® in Patients With Acute Myelogenous Leukemia (AML) Completed NCT00304447 Phase 4 Mylotarg
37 A Phase IV Study of Nilotinib in Patients With Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) Who Have Suboptimal Molecular Response on Imatinib Completed NCT01043874 Phase 4 Nilotinib
38 A Phase IV, Open-label, Multicenter Study of Dasatinib in Chronic-Phase Chronic Myeloid Leukemia (CP-CML) Patients With Chronic, Low-grade Non-Hematologic Toxicity to Imatinib Completed NCT01660906 Phase 4 Dasatinib
39 A Single-arm, Open-label, Multi-center Study of Complete Molecular Response (CMR) in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) Completed NCT01227577 Phase 4 Nilotinib
40 Gleevec Trial in Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia Completed NCT00081926 Phase 4 Gleevec
41 The Study on the Pharmacokinetics of Pegylated Recombinant Human Granulocyte Stimulating Factor(PEG-rhG-CSF) in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
42 Multicenter Trial for Treatment of Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
43 An Open-label, Multicenter Study of Oral AMN107 (Nilotinib) in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase Previously Enrolled to ENACT (CAMN107A2109) Trial Completed NCT01368523 Phase 4 nilotinib
44 A Multicenter Study to Confirm the Efficacy and Safety of Fludara i.v. (Fludarabine Phosphate, SH L 573), Administered in 6 Treatment Cycles (1 Treatment Cycle: 5-consecutive Day Dosing, Followed by an Observation Period of 23 Days) in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
45 A Single-arm, International, Multi-center Trial Investigating the Efficacy and Safety of Ofatumumab Retreatment and Maintenance in CLL Patients Who Progressed Following Response or Stable Disease After Ofatumumab Treatment in Hx-CD20-406 Completed NCT00802737 Phase 4 Ofatumumab
46 HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL) Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
47 A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
48 Randomised Multicentre Phase IV Study to Compare Glivec® (Imatinib Mesylate, STI571) in Monotherapy Versus Glivec® in Combination With Interferon Alpha at Low Doses in the Treatment of Newly-Diagnosed Chronic-Phase Chronic Myeloid Leukaemia Completed NCT00390897 Phase 4 Glivec;Interferon
49 Pulses of Vincristine and Dexamethasone During Maintenance in BFM Protocols for Children With Intermediate-Risk Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
50 Multicenter Trial for Treatment of Acute Lymphocytic Leukemia in Adults (Pilot Study 06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide

Search NIH Clinical Center for Leukemia

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Betamethasone
Bupivacaine
Cytarabine
Cytarabine liposome
Hydrocortisone
irinotecan
Irinotecan hydrochloride
Isotretinoin
Methotrexate
Methotrexate Sodium
Pipobroman
Prednisone
Triamcinolone
Vincristine
Vincristine Sulfate

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: leukemia

Genetic Tests for Leukemia

Genetic tests related to Leukemia:

# Genetic test Affiliating Genes
1 Leukemia 29

Anatomical Context for Leukemia

MalaCards organs/tissues related to Leukemia:

41
Myeloid, T Cells, B Cells, Bone, Bone Marrow, Monocytes, Testes

Publications for Leukemia

Articles related to Leukemia:

(show top 50) (show all 49632)
# Title Authors PMID Year
1
Hypoxia Up-regulates HIF Expression While Suppressing Cell Growth and NOTCH Activity in Leukaemia Cells. 17
31366501 2019
2
Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes. 17
31262901 2019
3
New treatment options in hairy cell leukemia with focus on BRAF inhibitors. 17
31187521 2019
4
Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia. 88
21070600 2011
5
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia. 9 38
20435628 2010
6
Activation of Ras-dependent Elk-1 activity by MLL-AF4 family fusion oncoproteins. 9 38
20362031 2010
7
Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia. 9 38
20484815 2010
8
Wilms' tumor gene 1 protein represses the expression of the tumor suppressor interferon regulatory factor 8 in human hematopoietic progenitors and in leukemic cells. 9 38
20237505 2010
9
Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. 9 38
20237320 2010
10
Expression pattern of the septin gene family in acute myeloid leukemias with and without MLL-SEPT fusion genes. 9 38
19748670 2010
11
LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate. 9 38
19701750 2010
12
Nup98-homeodomain fusions interact with endogenous Nup98 during interphase and localize to kinetochores and chromosome arms during mitosis. 9 38
20237156 2010
13
[Epigenetic mechanism of RUNX1 in pathogenesis of leukemia]. 9 38
20416203 2010
14
MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1. 9 38
20332322 2010
15
STAT5 in B cell development and leukemia. 9 38
20227268 2010
16
Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia. 9 38
20062079 2010
17
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein. 9 38
20236310 2010
18
c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin. 9 38
20124512 2010
19
Kinamycin F downregulates cyclin D3 in human leukemia K562 cells. 9 38
20079721 2010
20
Analysis of Ikaros family splicing variants in human hematopoietic lineages. 9 38
20432734 2010
21
Ordering human CD34+CD10-CD19+ pre/pro-B-cell and CD19- common lymphoid progenitor stages in two pro-B-cell development pathways. 9 38
20231472 2010
22
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). 9 38
20170098 2010
23
The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs. 9 38
20038611 2010
24
Functional characterization of high levels of meningioma 1 as collaborating oncogene in acute leukemia. 9 38
20072157 2010
25
KIR2DS3 is associated with protection against acute myeloid leukemia. 9 38
20371915 2010
26
MEIS proteins as partners of the TLX1/HOX11 oncoprotein. 9 38
19559479 2010
27
Xenotropic murine leukemia virus-related virus is susceptible to AZT. 9 38
19959199 2010
28
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. 9 38
20008304 2010
29
Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway. 9 38
20008789 2010
30
The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal. 9 38
20093438 2010
31
Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms. 9 38
19801969 2010
32
Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias. 9 38
19919827 2010
33
Impact of breast cancer resistance protein on cancer treatment outcomes. 9 38
19949928 2010
34
Estrogen prevents sustained COLO-205 human colon cancer cell growth by inducing apoptosis, decreasing c-myb protein, and decreasing transcription of the anti-apoptotic protein bcl-2. 9 38
20237898 2010
35
Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines. 9 38
20084277 2010
36
Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells. 9 38
19887369 2010
37
[Expression of c-fes gene in leukemia cells and its clinical significance]. 9 38
20030920 2009
38
Contribution of bone microenvironment to leukemogenesis and leukemia progression. 9 38
19727127 2009
39
Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis. 9 38
19907659 2009
40
Epigenetic alterations in a murine model for chronic lymphocytic leukemia. 9 38
19901553 2009
41
Genome wide molecular analysis of minimally differentiated acute myeloid leukemia. 9 38
19773259 2009
42
Effects of Manisa propolis on telomerase activity in leukemia cells obtained from the bone marrow of leukemia patients. 9 38
19817639 2009
43
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease. 9 38
19734451 2009
44
The cytotoxic effects of gemtuzumab ozogamicin (mylotarg) in combination with conventional antileukemic agents by isobologram analysis in vitro. 9 38
20032408 2009
45
Investigational drugs targeting FLT3 for leukemia. 9 38
19671038 2009
46
Transformation from committed progenitor to leukemia stem cells. 9 38
19796242 2009
47
Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant. 9 38
19682090 2009
48
HLA-DRneg patients without acute promyelocytic leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic characteristics compared to acute promyelocytic leukemia. 9 38
19291801 2009
49
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. 9 38
19556245 2009
50
STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells. 9 38
19709433 2009