ALL3
MCID: LKM062
MIFTS: 68

Leukemia, Acute Lymphoblastic (ALL3)

Categories: Blood diseases, Cancer diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Leukemia, Acute Lymphoblastic

MalaCards integrated aliases for Leukemia, Acute Lymphoblastic:

Name: Leukemia, Acute Lymphoblastic 58 76 13 39
Acute Lymphoblastic Leukemia 39 77 54 30 6 17
All 58 54 76
Leukemia, Acute Lymphocytic, Susceptibility to, 1 58 13
Leukemia, Acute Lymphoblastic, Susceptibility to 30 6
B-Cell Acute Lymphoblastic Leukemia 38 17
Acute Lymphocytic Leukemia 54 74
Leukemia, Acute Lymphoblastic, Susceptibility to, 3 74
Precursor Cell Lymphoblastic Leukemia-Lymphoma 45
Precursor Cell Lymphoblastic Leukemia Lymphoma 74
Leukemia Acute Lymphoblastic B-Hyperdiploid 76
Childhood Acute Lymphoblastic Leukemia 76
Leukemia, Acute, Lymphoblastic, T-Cell 41
Leukemia, T-Cell Acute Lymphoblastic 41
Leukemia B-Cell Acute Lymphoblastic 76
Leukemia T-Cell Acute Lymphoblastic 76
Leukemia, Acute Lymphoblastic, 3 76
Leukemia, Lymphocytic, Acute, L1 74
Leukemia Acute Lymphoblastic 1 76
Leukemia, Acute, Lymphoblastic 41
Leukemia, Acute Lymphocytic 1 58
Leukemia Acute Lymphocytic 1 76
Lymphoblastic Leukemia Acute 56
Leukemia Acute Lymphocytic 76
All3 76
All1 76

Characteristics:

HPO:

33
leukemia, acute lymphoblastic:
Inheritance polygenic inheritance


Classifications:



Summaries for Leukemia, Acute Lymphoblastic

NIH Rare Diseases : 54 Acute lymphoblastic leukemia (ALL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). It may develop in children or adults. ALL spreads to the blood fairly quickly, and then may spread to other areas of the body such as the lymph nodes, liver, spleen, central nervous system, and testicles (in males). Signs and symptoms of ALL may include fever, easy bruising or bleeding, feeling tired, loss of appetite, pain in the bones or abdomen, and painless lumps in the neck, underarm, stomach, or groin. ALL is typically caused by random, non-inherited changes in the DNA of immature lymphocytes called lymphoblasts. However, some people may inherit a genetic susceptibility to developing ALL. The risk to develop ALL may also be increased by past treatment for cancer, and by having certain genetic conditions or syndromes. Having one or more risk factors does not mean that a person definitely will develop ALL. Treatment of ALL depends on the person's age, how advanced the cancer is, and whether certain genetic changes are found in cancer cells. Treatment options may involve systemic and/or intrathecal chemotherapy, radiation therapy, targeted therapy, and/or a stem cell transplant. Biologic therapy and chimeric antigen receptor (CAR) T-cell therapy are currently being studied as treatment options and may be used when other therapies are not working. The chance of recovery also depends on many factors. With treatment, about 98% of children with ALL go into remission, and 85% of those with first-time ALL are expected have no long-term complications. The chance of recovery for adults is not as high, as 20-40% of adults are cured with current treatments.

MalaCards based summary : Leukemia, Acute Lymphoblastic, also known as acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic 3 and lymphoid leukemia, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Leukemia, Acute Lymphoblastic is PAX5 (Paired Box 5), and among its related pathways/superpathways are Transcriptional misregulation in cancer and MicroRNAs in cancer. The drugs Methotrexate and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotypes are acute lymphoblastic leukemia and neoplasm

OMIM : 58 Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). (613065)

UniProtKB/Swiss-Prot : 76 Leukemia, acute lymphoblastic: A subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes. Leukemia, acute lymphoblastic, 3: A subtype of acute leukemia, a cancer of the white blood cells. Acute lymphoblastic anemia is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphnodes.

Wikipedia : 77 Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the... more...

Related Diseases for Leukemia, Acute Lymphoblastic

Diseases in the Leukemia, Acute Lymphoblastic family:

Leukemia, Acute Lymphoblastic 2 Leukemia, Acute Lymphoblastic 3

Diseases related to Leukemia, Acute Lymphoblastic via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 706, show less)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 3 34.4 ETV6 FLT3 PAX5
2 lymphoid leukemia 30.6 ETV6 FLT3 GNB1 NBN
3 bone marrow cancer 30.6 ETV6 FLT3 MIR155
4 dermatomyositis 30.5 MIR130A MIR155 MIR199B
5 glioblastoma 30.4 MIR128-1 MIR130A MIR23A MIR451A
6 polymyositis 30.4 MIR130A MIR155
7 acute leukemia 30.3 ETV6 FLT3 PAX5
8 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.3 ETV6 FLT3
9 leukemia, acute myeloid 29.9 ETV6 FLT3 MIR128-1 MIR128-2 MIR130A MIR130B
10 hepatocellular carcinoma 29.9 MIR128-2 MIR130A MIR152 MIR155 MIR199B MIR203A
11 acute lymphoblastic leukemia, childhood 12.9
12 b-cell childhood acute lymphoblastic leukemia 12.8
13 precursor t-cell acute lymphoblastic leukemia 12.5
14 leukemia, acute lymphoblastic 2 12.5
15 acute lymphoblastic leukemia congenital sporadic aniridia 12.3
16 acute t cell leukemia 12.2
17 t-cell childhood acute lymphocytic leukemia 12.1
18 b-cell adult acute lymphocytic leukemia 12.0
19 null-cell leukemia 11.8
20 lymphoblastic lymphoma 11.7
21 acute lymphocytic leukemia 11.7
22 bone marrow necrosis 11.7
23 lymphoblastic leukemia, acute, with lymphomatous features 11.7
24 medulloblastoma 11.7
25 precursor lymphoblastic lymphoma/leukemia 11.6
26 t-cell adult acute lymphocytic leukemia 11.3
27 hematopoietic stem cell transplantation 10.8
28 lymphocytic leukemia 10.7
29 leukemia 10.7
30 prostate cancer 10.6
31 down syndrome 10.6
32 osteonecrosis 10.6
33 carney complex, type 1 10.6
34 caronte 10.6
35 glucocorticoid resistance, generalized 10.6
36 sarcoma 10.5
37 lymphoma, hodgkin, classic 10.5
38 leukemia, chronic myeloid 10.5
39 mucositis 10.5
40 burkitt lymphoma 10.5
41 lymphoma, non-hodgkin, familial 10.5
42 neutropenia 10.5
43 thrombosis 10.5
44 mucormycosis 10.5
45 neuropathy 10.5
46 hypereosinophilic syndrome 10.5
47 pancreatitis 10.5
48 wilms tumor 5 10.5
49 wilms tumor 6 10.5
50 graft-versus-host disease 10.4
51 chromosomal triplication 10.4
52 xp22.3 microdeletion syndrome 10.4
53 leukemia, chronic lymphocytic 2 10.4
54 leukemia, chronic lymphocytic 10.4
55 pancytopenia 10.4
56 leukemia, b-cell, chronic 10.4
57 encephalopathy 10.4
58 leiomyoma, uterine 10.4 MIR203A MIR451A MIRLET7C
59 ataxia-telangiectasia 10.4
60 aspergillosis 10.4
61 hepatitis 10.4
62 allergic hypersensitivity disease 10.4
63 pancreatic ductal adenocarcinoma 10.4 MIR130B MIR155 MIR203A
64 myelofibrosis 10.4
65 myelodysplastic syndrome 10.4
66 nonalcoholic fatty liver disease 10.4 MIR130A MIR203A MIR451A MIRLET7C
67 hypertriglyceridemia, familial 10.4
68 hemophagocytic lymphohistiocytosis 10.4
69 histiocytosis 10.4
70 pneumonia 10.4
71 telangiectasis 10.3
72 peripheral nervous system disease 10.3
73 retinoblastoma 10.3
74 retinitis 10.3
75 oral squamous cell carcinoma 10.3 MIR128-1 MIR155 MIR199B MIR203A MIR23A
76 spondylocarpotarsal synostosis syndrome 10.3
77 body mass index quantitative trait locus 1 10.3
78 fusariosis 10.3
79 purpura 10.3
80 lactic acidosis 10.3
81 hypoglycemia 10.3
82 histiocytic sarcoma 10.3
83 ataxia and polyneuropathy, adult-onset 10.3
84 aplastic anemia 10.3
85 cytomegalovirus retinitis 10.3
86 hyperglycemia 10.3
87 measles 10.3
88 chickenpox 10.3
89 rubella 10.3
90 meningitis 10.3
91 breast cancer 10.2
92 thrombophilia due to thrombin defect 10.2
93 polycythemia vera 10.2
94 langerhans cell histiocytosis 10.2
95 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.2
96 severe combined immunodeficiency 10.2
97 acute pancreatitis 10.2
98 mucoepidermoid carcinoma 10.2
99 combined t cell and b cell immunodeficiency 10.2
100 polycythemia 10.2
101 pfeiffer syndrome 10.2
102 noonan syndrome 1 10.2
103 retinal detachment 10.2
104 wilms tumor 1 10.2
105 fanconi anemia, complementation group a 10.2
106 juvenile myelomonocytic leukemia 10.2
107 ewing sarcoma 10.2
108 arthritis 10.2
109 invasive aspergillosis 10.2
110 hyperphosphatemia 10.2
111 hepatic veno-occlusive disease 10.2
112 disseminated intravascular coagulation 10.2
113 glioblastoma multiforme 10.2
114 central nervous system disease 10.2
115 influenza 10.2
116 malignant histiocytosis 10.2
117 nervous system disease 10.2
118 xanthogranulomatous cholecystitis 10.2
119 chronic graft versus host disease 10.2
120 cytokine deficiency 10.2
121 pseudo-turner syndrome 10.2
122 cytomegalovirus infection 10.2
123 diabetes mellitus, noninsulin-dependent 10.2
124 myeloma, multiple 10.2
125 neutrophil actin dysfunction 10.2
126 osteogenic sarcoma 10.2
127 acute liver failure 10.2
128 diabetes mellitus 10.2
129 follicular lymphoma 10.2
130 severe congenital neutropenia 10.2
131 lymphoproliferative syndrome 10.2
132 osteomyelitis 10.2
133 mumps 10.2
134 endocarditis 10.2
135 pneumocystosis 10.2
136 diphtheria 10.2
137 hemopericardium 10.2
138 pericardial effusion 10.2
139 subleukemic leukemia 10.2
140 wernicke encephalopathy 10.2
141 astrocytoma 10.2
142 aleukemic leukemia cutis 10.2
143 paraplegia 10.2
144 juvenile rheumatoid arthritis 10.2
145 myeloid sarcoma 10.2
146 acute graft versus host disease 10.2
147 acute monoblastic leukemia 10.2
148 growth hormone deficiency 10.2
149 hypoxia 10.2
150 b-cell growth factor 10.1
151 glioma susceptibility 1 10.1
152 osteoporosis 10.1
153 enterocolitis 10.1
154 thymoma, familial 10.1
155 anxiety 10.1
156 chronic myelomonocytic leukemia 10.1
157 hemolytic anemia 10.1
158 thalassemia 10.1
159 hypopyon 10.1
160 tetanus 10.1
161 nephrotic syndrome 10.1
162 papilledema 10.1
163 candidiasis 10.1
164 essential thrombocythemia 10.1
165 testicular disease 10.1
166 agammaglobulinemia 10.1
167 thymoma 10.1
168 sagittal sinus thrombosis 10.1
169 t-cell leukemia 10.1
170 hard palate cancer 10.1
171 encephalitis 10.1
172 acute leukemia of ambiguous lineage 10.1
173 pdgfrb-associated chronic eosinophilic leukemia 10.1
174 depression 10.1
175 leukemia, acute monocytic 10.1
176 rheumatoid arthritis 10.1
177 nijmegen breakage syndrome 10.1
178 fragile x syndrome 10.1
179 agammaglobulinemia, x-linked 10.1
180 aging 10.1
181 headache associated with sexual activity 10.1
182 acute promyelocytic leukemia 10.1
183 infantile liver failure syndrome 1 10.1
184 sclerosing cholangitis, neonatal 10.1
185 charcot-marie-tooth disease 10.1
186 hepatitis b 10.1
187 lymphomatoid granulomatosis 10.1
188 thrombocytopenia 10.1
189 hemorrhagic cystitis 10.1
190 ptosis 10.1
191 childhood acute myeloid leukemia 10.1
192 cryptococcal meningitis 10.1
193 parotitis 10.1
194 siderosis 10.1
195 tooth disease 10.1
196 respiratory failure 10.1
197 hemosiderosis 10.1
198 hemolytic-uremic syndrome 10.1
199 guillain-barre syndrome 10.1
200 obstructive jaundice 10.1
201 polyneuropathy 10.1
202 cystitis 10.1
203 ichthyosis 10.1
204 calcinosis 10.1
205 optic nerve disease 10.1
206 melanoma 10.1
207 hyperuricemia 10.1
208 rhabdomyosarcoma 10.1
209 spindle cell sarcoma 10.1
210 juvenile xanthogranuloma 10.1
211 hyperthyroidism 10.1
212 monocytic leukemia 10.1
213 vasculitis 10.1
214 priapism 10.1
215 diabetes insipidus 10.1
216 fasciitis 10.1
217 necrotizing fasciitis 10.1
218 germ cells tumors 10.1
219 heparin-induced thrombocytopenia 10.1
220 tetraploidy 10.1
221 triploidy 10.1
222 systemic lupus erythematosus 10.0
223 lupus erythematosus 10.0
224 lung cancer 10.0 MIR128-2 MIR130A MIR155 MIR199B MIR203A MIR451A
225 blood group, colton system 10.0
226 multiple sclerosis 10.0
227 intussusception 10.0
228 mastocytosis, cutaneous 10.0
229 cyclic neutropenia 10.0
230 thrombocytopenic purpura, autoimmune 10.0
231 anemia, autoimmune hemolytic 10.0
232 hemolytic uremic syndrome, atypical 1 10.0
233 myasthenia gravis 10.0
234 body mass index quantitative trait locus 11 10.0
235 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0
236 asthma 10.0
237 stroke, ischemic 10.0
238 body mass index quantitative trait locus 8 10.0
239 basal cell carcinoma 1 10.0
240 bone mineral density quantitative trait locus 3 10.0
241 body mass index quantitative trait locus 10 10.0
242 body mass index quantitative trait locus 7 10.0
243 avascular necrosis of femoral head, primary, 1 10.0
244 diabetes mellitus, ketosis-prone 10.0
245 body mass index quantitative trait locus 14 10.0
246 beta-thalassemia 10.0
247 dengue virus 10.0
248 body mass index quantitative trait locus 18 10.0
249 body mass index quantitative trait locus 19 10.0
250 cataract 10.0
251 dengue disease 10.0
252 muscle disorders 10.0
253 pemphigus foliaceus 10.0
254 sinusitis 10.0
255 interleukin-7 receptor alpha deficiency 10.0
256 colitis 10.0
257 hypogonadotropic hypogonadism 10.0
258 monocular esotropia 10.0
259 bacterial infectious disease 10.0
260 fanconi syndrome 10.0
261 portal hypertension 10.0
262 cauda equina syndrome 10.0
263 patau syndrome 10.0
264 ecthyma 10.0
265 hepatic coma 10.0
266 endomyocardial fibrosis 10.0
267 central nervous system leukemia 10.0
268 pneumatosis cystoides intestinalis 10.0
269 pure red-cell aplasia 10.0
270 hepatic encephalopathy 10.0
271 facial paralysis 10.0
272 critical illness polyneuropathy 10.0
273 hypothyroidism 10.0
274 panniculitis 10.0
275 urticaria 10.0
276 pericarditis 10.0
277 gaucher's disease 10.0
278 cholecystitis 10.0
279 dental caries 10.0
280 myeloproliferative neoplasm 10.0
281 gangliocytoma 10.0
282 basal cell carcinoma 10.0
283 acalculous cholecystitis 10.0
284 grade iii astrocytoma 10.0
285 oligodendroglioma 10.0
286 mastocytosis 10.0
287 pyoderma 10.0
288 myopathy 10.0
289 polyradiculopathy 10.0
290 folliculitis 10.0
291 endophthalmitis 10.0
292 ganglioneuroma 10.0
293 adenoma 10.0
294 appendicitis 10.0
295 pyoderma gangrenosum 10.0
296 herpes simplex 10.0
297 pyomyositis 10.0
298 leishmaniasis 10.0
299 macroglobulinemia 10.0
300 visceral leishmaniasis 10.0
301 hypopituitarism 10.0
302 intracranial hypertension 10.0
303 esotropia 10.0
304 47,xyy 10.0
305 demodicidosis 10.0
306 ewing's family of tumors 10.0
307 fasting hypoglycemia 10.0
308 granulocytopenia 10.0
309 homologous wasting disease 10.0
310 lymphosarcoma 10.0
311 myasthenia gravis congenital 10.0
312 rosai-dorfman disease 10.0
313 splenomegaly 10.0
314 headache 10.0
315 cerebral sinovenous thrombosis 10.0
316 xq12-q13.3 duplication syndrome 10.0
317 refractory anemia 10.0
318 lymphoma 10.0
319 acrodermatitis enteropathica, zinc-deficiency type 9.9
320 horns in sheep 9.9
321 acrodermatitis 9.9
322 poliomyelitis 9.9
323 enteropathica 9.9
324 glioma 9.9
325 acanthosis nigricans 9.8
326 alzheimer disease 9.8
327 atherosclerosis susceptibility 9.8
328 blood group, kidd system 9.8
329 colorectal cancer 9.8
330 hypercarotenemia and vitamin a deficiency, autosomal dominant 9.8
331 diabetes insipidus, nephrogenic, autosomal 9.8
332 erythermalgia, primary 9.8
333 gilbert syndrome 9.8
334 hypertension, essential 9.8
335 chromosome 5q deletion syndrome 9.8
336 marfan syndrome 9.8
337 meckel diverticulum 9.8
338 nondisjunction 9.8
339 ataxia-pancytopenia syndrome 9.8
340 myoclonus and ataxia 9.8
341 neurofibromatosis, type i 9.8
342 neurofibromatosis, type iv, of riccardi 9.8
343 nephrolithiasis, calcium oxalate 9.8
344 juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome 9.8
345 porphyria cutanea tarda 9.8
346 prader-willi syndrome 9.8
347 pulmonary hypertension, primary, 1 9.8
348 sarcoidosis 1 9.8
349 trigeminal neuralgia 9.8
350 williams-beuren syndrome 9.8
351 acth deficiency, isolated 9.8
352 adrenocortical carcinoma, hereditary 9.8
353 alstrom syndrome 9.8
354 bloom syndrome 9.8
355 cystic fibrosis 9.8
356 cystinuria 9.8
357 fanconi anemia, complementation group d2 9.8
358 hemochromatosis, type 1 9.8
359 miller-dieker lissencephaly syndrome 9.8
360 neuroblastoma 1 9.8
361 niemann-pick disease, type c1 9.8
362 ocular motor apraxia 9.8
363 oculotrichodysplasia 9.8
364 chronic recurrent multifocal osteomyelitis 9.8
365 phenylketonuria 9.8
366 hyperphenylalaninemia, bh4-deficient, c 9.8
367 pulmonary venoocclusive disease 1, autosomal dominant 9.8
368 rapadilino syndrome 9.8
369 knobloch syndrome 1 9.8
370 insulin-like growth factor i 9.8
371 weaver syndrome 9.8
372 wilson disease 9.8
373 arts syndrome 9.8
374 borjeson-forssman-lehmann syndrome 9.8
375 ichthyosis, x-linked 9.8
376 neurofibromatosis-noonan syndrome 9.8
377 yemenite deaf-blind hypopigmentation syndrome 9.8
378 focal segmental glomerulosclerosis 1 9.8
379 urinary tract infections, recurrent 9.8
380 rheumatoid arthritis, systemic juvenile 9.8
381 meningioma, radiation-induced 9.8
382 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8
383 nasopharyngeal carcinoma 9.8
384 meningioma, familial 9.8
385 hypereosinophilic syndrome, idiopathic 9.8
386 myocardial infarction 9.8
387 severe cutaneous adverse reaction 9.8
388 ichthyosis prematurity syndrome 9.8
389 lung cancer susceptibility 1 9.8
390 hepatitis c virus 9.8
391 west nile virus 9.8
392 intraocular pressure quantitative trait locus 9.8
393 antithrombin iii deficiency 9.8
394 myxoid liposarcoma 9.8
395 muscle hypertrophy 9.8
396 mannose-binding lectin deficiency 9.8
397 multiple enchondromatosis, maffucci type 9.8
398 meconium ileus 9.8
399 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.8
400 melioidosis 9.8
401 pulmonary hypertension 9.8
402 adrenal cortical carcinoma 9.8
403 adult acute lymphocytic leukemia 9.8
404 adult respiratory distress syndrome 9.8
405 alopecia 9.8
406 anaplastic large cell lymphoma 9.8
407 b-cell lymphomas 9.8
408 bronchiolitis obliterans 9.8
409 cerebral hemorrhage 9.8
410 chronic granulomatous disease 9.8
411 common variable immunodeficiency 9.8
412 crohn's disease 9.8
413 diffuse large b-cell lymphoma 9.8
414 dilated cardiomyopathy 9.8
415 focal segmental glomerulosclerosis 9.8
416 glomerulonephritis 9.8
417 hereditary hemorrhagic telangiectasia 9.8
418 ichthyosis lamellar 1 9.8
419 joint disorders 9.8
420 mantle cell lymphoma 9.8
421 nephrolithiasis 9.8
422 niemann-pick disease 9.8
423 precursor b lymphoblastic lymphoma/leukemia 9.8
424 retinal vein occlusion 9.8
425 skin disease 9.8
426 small non-cleaved cell lymphoma 9.8
427 systemic mastocytosis 9.8
428 temporal lobe epilepsy 9.8
429 waldenstrom macroglobulinemia 9.8
430 cryptogenic organizing pneumonia 9.8
431 granulomatous amebic encephalitis 9.8
432 conidiobolomycosis 9.8
433 hypophosphatemia 9.8
434 exanthem 9.8
435 inflammatory bowel disease 9.8
436 vitamin b12 deficiency 9.8
437 infective endocarditis 9.8
438 withdrawal disorder 9.8
439 janus kinase-3 deficiency 9.8
440 immunoglobulin alpha deficiency 9.8
441 b cell linker protein deficiency 9.8
442 aphasia 9.8
443 clostridium difficile colitis 9.8
444 autosomal recessive congenital ichthyosis 9.8
445 bone disease 9.8
446 bone resorption disease 9.8
447 igg4-related disease 9.8
448 chronic eosinophilic leukemia 9.8
449 eosinophilic meningitis 9.8
450 tonsillitis 9.8
451 meningoencephalitis 9.8
452 glucose intolerance 9.8
453 thrombotic thrombocytopenic purpura 9.8
454 methemoglobinemia 9.8
455 filariasis 9.8
456 japanese encephalitis 9.8
457 abducens nerve disease 9.8
458 strongyloidiasis 9.8
459 lipoid nephrosis 9.8
460 discitis 9.8
461 brucellosis 9.8
462 henoch-schoenlein purpura 9.8
463 pertussis 9.8
464 megacolon 9.8
465 spinal meningioma 9.8
466 pulmonary edema 9.8
467 heart disease 9.8
468 horner's syndrome 9.8
469 cardiac tamponade 9.8
470 listeriosis 9.8
471 infant gynecomastia 9.8
472 protein-energy malnutrition 9.8
473 conn's syndrome 9.8
474 optic neuritis 9.8
475 aseptic meningitis 9.8
476 testicular leukemia 9.8
477 vogt-koyanagi-harada disease 9.8
478 patulous eustachian tube 9.8
479 bell's palsy 9.8
480 hepatitis a 9.8
481 nephrocalcinosis 9.8
482 gynecomastia 9.8
483 choreatic disease 9.8
484 balanitis 9.8
485 bronchus cancer 9.8
486 porphyria 9.8
487 ehlers-danlos syndrome 9.8
488 leopard syndrome 9.8
489 pleuropneumonia 9.8
490 capillary leak syndrome 9.8
491 breast fibroadenoma 9.8
492 pneumothorax 9.8
493 cryptosporidiosis 9.8
494 toxic megacolon 9.8
495 thyroid cancer 9.8
496 neuritis 9.8
497 epilepsy 9.8
498 hepatitis c 9.8
499 malignant fibroxanthoma 9.8
500 hyperostosis 9.8
501 hereditary multiple exostoses 9.8
502 intestinal perforation 9.8
503 atypical teratoid rhabdoid tumor 9.8
504 blood platelet disease 9.8
505 thrombocytosis 9.8
506 nocardiosis 9.8
507 gastroenteritis 9.8
508 post-thrombotic syndrome 9.8
509 central retinal vein occlusion 9.8
510 thrombophilia 9.8
511 orchitis 9.8
512 splenic infarction 9.8
513 cystadenoma 9.8
514 perivascular epithelioid cell tumor 9.8
515 dermatitis 9.8
516 bilirubin metabolic disorder 9.8
517 long qt syndrome 9.8
518 glucosephosphate dehydrogenase deficiency 9.8
519 bronchiolitis 9.8
520 pulmonary tuberculosis 9.8
521 antiphospholipid syndrome 9.8
522 acinar cell carcinoma 9.8
523 papillary carcinoma 9.8
524 myelitis 9.8
525 thymic carcinoma 9.8
526 liposarcoma 9.8
527 cellulitis 9.8
528 turner syndrome 9.8
529 choroid plexus cancer 9.8
530 cavernous sinus thrombosis 9.8
531 toxic encephalopathy 9.8
532 empty sella syndrome 9.8
533 pericoronitis 9.8
534 rhabdoid cancer 9.8
535 porokeratosis 9.8
536 arthropathy 9.8
537 cranial nerve palsy 9.8
538 pituitary adenoma 9.8
539 craniopharyngioma 9.8
540 adrenal cortical adenocarcinoma 9.8
541 loeffler endocarditis 9.8
542 spindle cell carcinoma 9.8
543 histiocytoma 9.8
544 polyradiculoneuropathy 9.8
545 erdheim-chester disease 9.8
546 hepatitis e 9.8
547 fibrous histiocytoma 9.8
548 seminoma 9.8
549 hypokalemia 9.8
550 pleomorphic adenoma 9.8
551 secretory meningioma 9.8
552 ureteral obstruction 9.8
553 human immunodeficiency virus infectious disease 9.8
554 pulmonary venoocclusive disease 9.8
555 pediatric lymphoma 9.8
556 ectopic thymus 9.8
557 cll/sll 9.8
558 central pontine myelinolysis 9.8
559 bilateral breast cancer 9.8
560 juvenile pilocytic astrocytoma 9.8
561 compartment syndrome 9.8
562 hepatoblastoma 9.8
563 leber hereditary optic neuropathy 9.8
564 thyroiditis 9.8
565 anthrax disease 9.8
566 septic arthritis 9.8
567 extrinsic allergic alveolitis 9.8
568 intestinal obstruction 9.8
569 paralytic ileus 9.8
570 herpes zoster 9.8
571 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.8
572 eating disorder 9.8
573 perinatal necrotizing enterocolitis 9.8
574 molluscum contagiosum 9.8
575 evans' syndrome 9.8
576 sideroblastic anemia 9.8
577 amyloidosis 9.8
578 exophthalmos 9.8
579 iridocyclitis 9.8
580 epiglottitis 9.8
581 epididymo-orchitis 9.8
582 otitis externa 9.8
583 krukenberg carcinoma 9.8
584 noma 9.8
585 alopecia areata 9.8
586 follicular mucinosis 9.8
587 steroid-induced glaucoma 9.8
588 toxoplasmosis 9.8
589 hyperphenylalaninemia 9.8
590 microcephaly 9.8
591 hereditary multiple osteochondromas 9.8
592 juvenile hereditary hemochromatosis 9.8
593 noonan syndrome with multiple lentigines 9.8
594 acute non lymphoblastic leukemia 9.8
595 acute respiratory distress syndrome 9.8
596 al amyloidosis 9.8
597 anaplastic oligoastrocytoma 9.8
598 anaplastic oligodendroglioma 9.8
599 anterior uveitis 9.8
600 arachnoid cysts 9.8
601 boerhaave syndrome 9.8
602 carcinoid syndrome 9.8
603 childhood non-hodgkin lymphoma 9.8
604 congenital rubella 9.8
605 desmoplastic small round cell tumor 9.8
606 dwarfism 9.8
607 eosinophilic pustular folliculitis 9.8
608 fournier gangrene 9.8
609 haemophilus influenzae 9.8
610 hereditary antithrombin deficiency 9.8
611 hhv-6 encephalitis 9.8
612 human t-cell leukemia virus type 1 9.8
613 knobloch syndrome 9.8
614 lipogranulomatosis 9.8
615 lymphocytic vasculitis 9.8
616 macrophage activation syndrome 9.8
617 mediastinal endodermal sinus tumors 9.8
618 meralgia paresthetica 9.8
619 mycobacterium chelonae 9.8
620 nonalcoholic steatohepatitis 9.8
621 oligoastrocytoma 9.8
622 oral cancer 9.8
623 pilocytic astrocytoma 9.8
624 polymorphic reticulosis 9.8
625 precocious puberty 9.8
626 reversible cerebral vasoconstriction syndrome 9.8
627 ring chromosome 16 9.8
628 ring chromosome 21 9.8
629 simpson-golabi-behmel syndrome 9.8
630 spitz nevus 9.8
631 stenotrophomonas maltophilia infection 9.8
632 systemic capillary leak syndrome 9.8
633 systemic onset juvenile idiopathic arthritis 9.8
634 testicular seminoma 9.8
635 thiopurine s methyltranferase deficiency 9.8
636 thrombasthenia 9.8
637 tracheoesophageal fistula 9.8
638 tuberculous meningitis 9.8
639 undifferentiated pleomorphic sarcoma 9.8
640 virus associated hemophagocytic syndrome 9.8
641 8p11 myeloproliferative syndrome 9.8
642 seizure disorder 9.8
643 cerebral atrophy 9.8
644 extrapontine myelinolysis 9.8
645 rapidly involuting congenital hemangioma 9.8
646 hemophagocytic syndrome associated with an infection 9.8
647 recurrent acute pancreatitis 9.8
648 argyria 9.8
649 diffuse alveolar hemorrhage 9.8
650 classic phenylketonuria 9.8
651 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.8
652 acute myeloid leukemia with minimal differentiation 9.8
653 pelger-huet anomaly 9.8
654 paroxysmal nocturnal hemoglobinuria 9.8
655 hemoglobinuria 9.8
656 childhood leukemia 9.8
657 myeloid leukemia 9.8
658 beckwith-wiedemann syndrome 9.7
659 erythroleukemia, familial 9.7
660 keratitis, hereditary 9.7
661 polykaryocytosis inducer 9.7
662 smith-magenis syndrome 9.7
663 varicose veins 9.7
664 chediak-higashi syndrome 9.7
665 3-methylglutaconic aciduria, type iii 9.7
666 anorexia nervosa 9.7
667 thiopurines, poor metabolism of, 1 9.7
668 microvascular complications of diabetes 5 9.7
669 noonan syndrome 6 9.7
670 ras-associated autoimmune leukoproliferative disorder 9.7
671 adult t-cell leukemia 9.7
672 trichosporonosis 9.7
673 paralytic poliomyelitis 9.7
674 cutaneous t cell lymphoma 9.7
675 diffuse alopecia areata 9.7
676 basal ganglia calcification 9.7
677 oral hairy leukoplakia 9.7
678 cholelithiasis 9.7
679 esophageal varix 9.7
680 chagas disease 9.7
681 uveitis 9.7
682 diarrhea 9.7
683 beriberi 9.7
684 necrotizing ulcerative gingivitis 9.7
685 thrombocytopenia due to platelet alloimmunization 9.7
686 lymphadenitis 9.7
687 histoplasmosis 9.7
688 brain sarcoma 9.7
689 blepharoconjunctivitis 9.7
690 iga glomerulonephritis 9.7
691 gingivitis 9.7
692 blepharochalasis 9.7
693 pituitary gland disease 9.7
694 brown-sequard syndrome 9.7
695 progressive multifocal leukoencephalopathy 9.7
696 macular holes 9.7
697 myocarditis 9.7
698 peritonitis 9.7
699 actinomycosis 9.7
700 viral exanthem 9.7
701 erythema infectiosum 9.7
702 sickle cell disease 9.7
703 bk-virus nephropathy 9.7
704 leukoplakia 9.7
705 mycobacterium abscessus 9.7
706 parvovirus antenatal infection 9.7

Graphical network of the top 20 diseases related to Leukemia, Acute Lymphoblastic:



Diseases related to Leukemia, Acute Lymphoblastic

Symptoms & Phenotypes for Leukemia, Acute Lymphoblastic

Human phenotypes related to Leukemia, Acute Lymphoblastic:

33 (showing 1, show less)
# Description HPO Frequency HPO Source Accession
1 acute lymphoblastic leukemia 33 HP:0006721

Clinical features from OMIM:

613065

UMLS symptoms related to Leukemia, Acute Lymphoblastic:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Leukemia, Acute Lymphoblastic:

47 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 ACTB ETV6 FLT3 NBN PAX5 PMS2

Drugs & Therapeutics for Leukemia, Acute Lymphoblastic

Drugs for Leukemia, Acute Lymphoblastic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 656, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
2
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
3
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302962-49-8 3062316
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 143 6006
7
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58957-92-9 42890
8
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
9
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
10
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
11
Mercaptopurine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-44-2 667490
12
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 123774-72-1, 83869-56-1
13
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
14
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
15
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
17
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
18
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
19
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
20
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
21
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
22
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 4291-63-8 20279
23
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
24
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 154-42-7 2723601
25
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 75607-67-9, 21679-14-1 30751
26
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53643-48-4, 59917-39-4 40839
27
Teniposide Approved Phase 4,Phase 3,Phase 2,Not Applicable 29767-20-2 34698
28
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 3778-73-2 3690
29
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-03-3
30
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
31
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 65271-80-9 4212
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
33
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
34
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 55-98-1 2478
35
Epirubicin Approved Phase 4,Phase 3,Phase 2 56420-45-2 41867
36
Posaconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 171228-49-2 147912
37
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
38
Methylphenidate Approved, Investigational Phase 4,Not Applicable 113-45-1 4158
39
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
40
Oprelvekin Approved, Investigational Phase 4 145941-26-0
41
inotuzumab ozogamicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 635715-01-4
42
Azacitidine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 320-67-2 9444
43
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 2353-33-5 451668
44
Morphine Approved, Investigational Phase 4,Phase 3,Not Applicable 57-27-2 5288826
45
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
46
tannic acid Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 1401-55-4
47
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
48
Nicotine Approved Phase 4 54-11-5 89594 942
49
Tyrosine Approved, Investigational, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 60-18-4 6057
50
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
51
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
52
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-14-6 5280793
53
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 1406-16-2
54
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731 6433735