Leukemia, Acute Lymphoblastic 3 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

ALL3 MCID: LKM060 MIFTS: 48	Leukemia, Acute Lymphoblastic 3 (ALL3) Categories: Blood diseases, Cancer diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for Leukemia, Acute Lymphoblastic 3

MalaCards integrated aliases for Leukemia, Acute Lymphoblastic 3:

Name: Leukemia, Acute Lymphoblastic 3 ⁵⁷

Leukemia, Acute Lymphoblastic, Susceptibility to, 3 ⁵⁷ ²⁹ ⁶ ⁴⁰ ⁷³

B-All ⁵⁹ ⁵⁵

Precursor B-Cell Acute Lymphoblastic Leukemia/lymphoma ⁵⁹

Precursor B-Cell Acute Lymphocytic Leukemia/lymphoma ⁵⁹

Precursor B-Cell Lymphoblastic Leukemia-Lymphoma ⁷³

Precursor B-Cell Acute Lymphoblastic Leukemia ⁵⁹

Precursor B-Cell Acute Lymphocytic Leukemia ⁵⁹

Precursor B-Cell Lymphoblastic Leukemia ⁷³

Burkitt Lymphoma ⁷³

All3 ⁵⁷

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Lymphoid leukaemia

Acute lymphoblastic leukaemia [ALL]

Non-follicular lymphoma

Lymphoblastic (diffuse) lymphoma

Orphanet: ⁵⁹

Rare haematological diseases

External Ids:

OMIM ⁵⁷ 615545

Orphanet ⁵⁹ ORPHA99860

ICD10 via Orphanet ³⁴ C91.0 C83.5

UMLS via Orphanet ⁷⁴ C0006413 C1292769

MedGen ⁴² C3809874

UMLS ⁷³ C3809874 C0023485 C0006413 more

Sources

Summaries for Leukemia, Acute Lymphoblastic 3

MalaCards based summary : Leukemia, Acute Lymphoblastic 3, also known as leukemia, acute lymphoblastic, susceptibility to, 3, is related to leukemia, acute lymphoblastic and lymphocytic leukemia, and has symptoms including bone pain An important gene associated with Leukemia, Acute Lymphoblastic 3 is PAX5 (Paired Box 5), and among its related pathways/superpathways are Endometrial cancer and NF-kappaB Signaling. Affiliated tissues include b cells, bone and bone marrow, and related phenotypes are Decreased viability and Decreased viability

Description from OMIM: 615545

Sources

Related Diseases for Leukemia, Acute Lymphoblastic 3

Diseases in the Leukemia, Acute Lymphoblastic family:

Leukemia, Acute Lymphoblastic 2

Leukemia, Acute Lymphoblastic 3

Diseases related to Leukemia, Acute Lymphoblastic 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Related Disease	Score	Top Affiliating Genes
1	leukemia, acute lymphoblastic	32.9	ABL1 AFF1 BCR ETV6 FLT3 IGH
2	lymphocytic leukemia	31.6	BCR ETV6 KMT2A PAX5 RUNX1 TP53
3	leukemia	31.3	ABL1 BCR ETV6 FLT3 HLF PBX1
4	acute lymphocytic leukemia	31.0	BCR CDKN2A ETV6 PAX5 RUNX1 TP53
5	myeloproliferative neoplasm	30.5	ABL1 BCR PDGFRA
6	myelodysplastic syndrome	30.3	ABL1 ETV6 FLT3 KMT2A RUNX1 TP53
7	acute leukemia	30.2	AFF1 ETV6 FLT3 KMT2A PAX5 RUNX1
8	b-cell lymphomas	29.7	CDKN2A FOXP1 PAX5 TP53
9	precursor t-cell acute lymphoblastic leukemia	29.6	ABL1 BCR CDKN2A ETV6 FLT3 IGH
10	sarcoma	10.3
11	histiocytic sarcoma	10.3
12	ring chromosome 21	10.3	ETV6 KMT2A
13	philadelphia-negative chronic myeloid leukemia	10.3	ABL1 BCR
14	primary hypereosinophilic syndrome	10.3	ETV6 PDGFRA
15	lymphoid leukemia	10.3	ETV6 FLT3 KMT2A
16	b-cell adult acute lymphocytic leukemia	10.3	ABL1 PAX5 PBX1
17	myeloid sarcoma	10.3	FLT3 KMT2A PAX5
18	acute myeloid leukemia with t(8;21)(q22;q22) translocation	10.3	FLT3 RUNX1
19	loeffler endocarditis	10.3	ETV6 PDGFRA
20	b-cell childhood acute lymphoblastic leukemia	10.3	ETV6 RUNX1
21	chronic eosinophilic leukemia	10.3	ABL1 FLT3 PDGFRA
22	inverted transitional papilloma	10.3	CDKN2A GATA3
23	cellular neurofibroma	10.3	ABL1 TP53
24	hemophagocytic lymphohistiocytosis	10.3
25	lymphoblastic lymphoma	10.3
26	lymphoma	10.3
27	acute lymphoblastic leukemia, childhood	10.2	CDKN2A ETV6 RUNX1
28	8p11 myeloproliferative syndrome	10.2	BCR FLT3 RUNX1
29	atypical chronic myeloid leukemia	10.2	ABL1 PDGFRA RUNX1
30	cytogenetically normal acute myeloid leukemia	10.2	FLT3 KMT2A
31	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	10.2	ETV6 FLT3 KMT2A RUNX1
32	supratentorial cancer	10.2	CDKN2A PDGFRA TP53
33	cerebrum cancer	10.2	CDKN2A PDGFRA TP53
34	bartholin's duct cyst	10.2	GATA3 TP53
35	bladder squamous cell carcinoma	10.2	CDKN2A TP53
36	small cell carcinoma	10.2	CDKN2A PDGFRA TP53
37	central nervous system lymphoma	10.2	CDKN2A FOXP1 TP53
38	bartholin's gland disease	10.2	CDKN2A GATA3 TP53
39	grade iii astrocytoma	10.2	CDKN2A PDGFRA TP53
40	keratinizing squamous cell carcinoma	10.2	CDKN2A TP53
41	mantle cell lymphoma	10.2	CDKN2A IGH PAX5 TP53
42	chronic myelomonocytic leukemia	10.2	ETV6 FLT3 RUNX1
43	malignant peripheral nerve sheath tumor	10.2	CDKN2A PDGFRA TP53
44	spitz nevus	10.2	CDKN2A TP53
45	gastrointestinal system cancer	10.2	CDKN2A PDGFRA TP53
46	lymphoma, non-hodgkin, familial	10.1	BCR IGH PAX5 TP53
47	gastrointestinal stromal tumor	10.1	ABL1 CDKN2A FLT3 PDGFRA TP53
48	leukemia, acute monocytic	10.1
49	myasthenia gravis	10.1
50	myelofibrosis	10.1

Graphical network of the top 20 diseases related to Leukemia, Acute Lymphoblastic 3:

Sources

Symptoms & Phenotypes for Leukemia, Acute Lymphoblastic 3

Clinical features from OMIM:

615545

UMLS symptoms related to Leukemia, Acute Lymphoblastic 3:

bone pain

GenomeRNAi Phenotypes related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.99	BCR
2	Decreased viability	GR00173-A	9.99	FLT3 PDGFRA
3	Decreased viability	GR00221-A-1	9.99	ABL1 CDKN2A FLT3 PDGFRA PIP4K2A
4	Decreased viability	GR00221-A-2	9.99	ABL1 BCR
5	Decreased viability	GR00221-A-3	9.99	ABL1 CDKN2A PDGFRA
6	Decreased viability	GR00221-A-4	9.99	CDKN2A FLT3 PDGFRA PIP4K2A BCR
7	Decreased viability	GR00301-A	9.99	PIP4K2A BCR
8	Decreased viability	GR00342-S-1	9.99	ABL1
9	Decreased viability	GR00342-S-2	9.99	ABL1
10	Decreased viability	GR00342-S-3	9.99	ABL1 BCR
11	Decreased viability	GR00402-S-2	9.99	ABL1 CDKN2A FLT3 PDGFRA PIP4K2A BCR

MGI Mouse Phenotypes related to Leukemia, Acute Lymphoblastic 3:

⁴⁶ (show all 22)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.45	ABL1 AFF1 AUTS2 BCR CDKN2A ETV6
2	cellular	MP:0005384	10.44	ABL1 AUTS2 BCR CDKN2A ETV6 FLT3
3	behavior/neurological	MP:0005386	10.38	ABL1 AFF1 AUTS2 BCR CDKN2A HLF
4	hematopoietic system	MP:0005397	10.37	ABL1 AFF1 BCR CDKN2A ETV6 FLT3
5	mortality/aging	MP:0010768	10.36	ABL1 AFF1 AUTS2 BCR CDKN2A ETV6
6	cardiovascular system	MP:0005385	10.34	ABL1 AUTS2 CDKN2A ETV6 GATA3 HLF
7	endocrine/exocrine gland	MP:0005379	10.34	ABL1 AFF1 AUTS2 CDKN2A ETV6 FLT3
8	immune system	MP:0005387	10.34	ABL1 AFF1 BCR CDKN2A ETV6 FLT3
9	homeostasis/metabolism	MP:0005376	10.32	ABL1 BCR CDKN2A ETV6 FLT3 GATA3
10	embryo	MP:0005380	10.31	ABL1 AUTS2 CDKN2A ETV6 GATA3 KMT2A
11	digestive/alimentary	MP:0005381	10.18	ABL1 BCR CDKN2A ETV6 GATA3 PBX1
12	nervous system	MP:0003631	10.17	ABL1 AFF1 AUTS2 BCR CDKN2A GATA3
13	liver/biliary system	MP:0005370	10.16	ABL1 AUTS2 BCR CDKN2A HLF KMT2A
14	craniofacial	MP:0005382	10.13	ABL1 GATA3 KMT2A PAX5 PBX1 PDGFRA
15	neoplasm	MP:0002006	10.11	AUTS2 CDKN2A ETV6 FLT3 KMT2A PAX5
16	integument	MP:0010771	10.08	CDKN2A ETV6 GATA3 KMT2A PBX1 PDGFRA
17	no phenotypic analysis	MP:0003012	10.03	AFF1 AUTS2 CDKN2A ETV6 FLT3 GATA3
18	hearing/vestibular/ear	MP:0005377	10.01	BCR GATA3 KMT2A PAX5 PBX1 TP53
19	normal	MP:0002873	9.97	ABL1 BCR ETV6 GATA3 HLF KMT2A
20	muscle	MP:0005369	9.95	ABL1 CDKN2A GATA3 KMT2A PBX1 PDGFRA
21	renal/urinary system	MP:0005367	9.5	BCR GATA3 KMT2A PBX1 PDGFRA TCF3
22	skeleton	MP:0005390	9.32	ABL1 CDKN2A FLT3 GATA3 KMT2A PAX5

Sources

Drugs & Therapeutics for Leukemia, Acute Lymphoblastic 3

Search Clinical Trials , NIH Clinical Center for Leukemia, Acute Lymphoblastic 3

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

cyclophosphamide

Sources

Genetic Tests for Leukemia, Acute Lymphoblastic 3

Genetic tests related to Leukemia, Acute Lymphoblastic 3:

#	Genetic test	Affiliating Genes
1	Leukemia, Acute Lymphoblastic, Susceptibility to, 3 ²⁹	PAX5

Sources

Anatomical Context for Leukemia, Acute Lymphoblastic 3

MalaCards organs/tissues related to Leukemia, Acute Lymphoblastic 3:

⁴¹

B Cells, Bone, Bone Marrow, Colon, T Cells, Myeloid, Monocytes

Sources

Publications for Leukemia, Acute Lymphoblastic 3

Articles related to Leukemia, Acute Lymphoblastic 3:

#	Title	Authors	Year
1	Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report. ( 23533894 )	Hirzel A.C....Sriganeshan V.	2013

Sources

Genes for Leukemia, Acute Lymphoblastic 3

Genes related to Leukemia, Acute Lymphoblastic 3 (20 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	PAX5	Paired Box 5	Protein Coding	1085.2	Molecular basis known ⁵⁷ Gene fusion ⁵⁹ Genetic Tests ²⁹ Susceptibility factor ⁵⁷ ⁵⁹ Risk factor ⁶ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Variants (show sections)	16584581 20160164 16938666 (more) 20023257
2	KMT2A	Lysine Methyltransferase 2A	Protein Coding	368.64	Gene fusion ⁵⁹ Novoseek inferred ⁵⁵	15098014 16019540 19840468 (more) 18923441
3	ETV6	ETS Variant 6	Protein Coding	367.94	Gene fusion ⁵⁹ Novoseek inferred ⁵⁵	20197715
4	PBX1	PBX Homeobox 1	Protein Coding	367.04	Gene fusion ⁵⁹ Novoseek inferred ⁵⁵	15801954
5	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	366.59	Causative somatic mutation ⁵⁹ Novoseek inferred ⁵⁵	9399648 10634644 7833469 (more) 10360377 19837270 11721412 12870051
6	IGH	Immunoglobulin Heavy Locus	Protein Coding	359.91	Causative somatic mutation ⁵⁹ Novoseek inferred ⁵⁵	1909409 8315958 8161789 (more) 8630417 1850055 1554798 10889907 12744735
7	FLT3	Fms Related Tyrosine Kinase 3	Protein Coding	356.17	Causative somatic mutation ⁵⁹ Novoseek inferred ⁵⁵	8182945 10233379 16234090
8	BCR	BCR, RhoGEF And GTPase Activating Protein	Protein Coding	355.08	Gene fusion ⁵⁹ Novoseek inferred ⁵⁵	12855552
9	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	354.66	Gene fusion ⁵⁹ Novoseek inferred ⁵⁵	20082857 12744734
10	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	350	Gene fusion ⁵⁹
11	AUTS2	AUTS2, Activator Of Transcription And Developmental Regulator	Protein Coding	350	Gene fusion ⁵⁹
12	HLF	HLF, PAR BZIP Transcription Factor	Protein Coding	350	Gene fusion ⁵⁹
13	AFF1	AF4/FMR2 Family Member 1	Protein Coding	350	Gene fusion ⁵⁹
14	TCF3	Transcription Factor 3	Protein Coding	350	Gene fusion ⁵⁹
15	FOXP1	Forkhead Box P1	Protein Coding	350	Gene fusion ⁵⁹
16	RUNX1	Runt Related Transcription Factor 1	Protein Coding	350	Gene fusion ⁵⁹
17	HLA-C	Major Histocompatibility Complex, Class I, C	Protein Coding	25	Susceptibility factor ⁵⁹
18	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	25	Susceptibility factor ⁵⁹
19	GATA3	GATA Binding Protein 3	Protein Coding	25	Susceptibility factor ⁵⁹
20	TP53	Tumor Protein P53	Protein Coding	25	Susceptibility factor ⁵⁹
21	KITLG	KIT Ligand	Protein Coding	21.14	Novoseek inferred ⁵⁵	7535143 9477130 12634948
22	ANPEP	Alanyl Aminopeptidase, Membrane	Protein Coding	18.72	Novoseek inferred ⁵⁵	19562339 11195181 11697497 (more) 11699224 19143872 17434163
23	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	17.26	Novoseek inferred ⁵⁵	9399648 10634644 19837270 (more) 11721412
24	MPO	Myeloperoxidase	Protein Coding	16.95	Novoseek inferred ⁵⁵	9638984
25	CD19	CD19 Molecule	Protein Coding	16.75	Novoseek inferred ⁵⁵	16185473 16939815
26	MME	Membrane Metalloendopeptidase	Protein Coding	16.6	Novoseek inferred ⁵⁵	11237064 16185473 17430665 (more) 17652839
27	IL7	Interleukin 7	Protein Coding	16.32	Novoseek inferred ⁵⁵	2388482 9477130 8641369
28	CCR7	C-C Motif Chemokine Receptor 7	Protein Coding	16.21	Novoseek inferred ⁵⁵	16225771 17082584 16118018
29	PEG10	Paternally Expressed 10	Protein Coding	10.21	Novoseek inferred ⁵⁵	16225771 17082584
30	DNTT	DNA Nucleotidylexotransferase	Protein Coding	8.22	Novoseek inferred ⁵⁵	17430665 8683996 17652839
31	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	8.02	Novoseek inferred ⁵⁵	16225771 17082584 16118018 (more) 11368435

Sources

Variations for Leukemia, Acute Lymphoblastic 3

ClinVar genetic disease variations for Leukemia, Acute Lymphoblastic 3:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	PAX5	NM_001280547.1(PAX5): c.547G> A (p.Gly183Ser)	single nucleotide variant	risk factor	rs398123063	GRCh37	Chromosome 9, 37002702: 37002702
2	PAX5	NM_001280547.1(PAX5): c.547G> A (p.Gly183Ser)	single nucleotide variant	risk factor	rs398123063	GRCh38	Chromosome 9, 37002705: 37002705
3	PAX5	NM_016734.2(PAX5): c.1013-1G> A	single nucleotide variant	Uncertain significance		GRCh37	Chromosome 9, 36846927: 36846927
4	PAX5	NM_016734.2(PAX5): c.1013-1G> A	single nucleotide variant	Uncertain significance		GRCh38	Chromosome 9, 36846930: 36846930

Sources

Expression for Leukemia, Acute Lymphoblastic 3

Search GEO for disease gene expression data for Leukemia, Acute Lymphoblastic 3.

Sources

Pathways for Leukemia, Acute Lymphoblastic 3

Pathways related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.44	ABL1 BCR CDKN2A FLT3 PDGFRA RUNX1
2	NF-kappaB Signaling ⁴	12.37	GATA3 PAX5 PBX1 RUNX1 TCF3
3	MicroRNAs in cancer ³⁷	12.31	ABL1 CDKN2A FOXP1 PDGFRA TP53
4	Pathways in cancer ³⁷	12.22	ABL1 BCR CDKN2A FLT3 PDGFRA RUNX1
5	Human T-cell leukemia virus 1 infection ³⁷	12.17	CDKN2A HLA-C PDGFRA TCF3 TP53
6	Tyrosine Kinases / Adaptors ⁴	11.95	ABL1 BCR FLT3 PDGFRA
7	Senescence and Autophagy in Cancer ¹	11.75	CDKN2A KMT2A TP53
8	Glioblastoma Multiforme ⁶⁴	11.75	CDKN2A PDGFRA TCF3 TP53
9	Glucocorticoid receptor regulatory network ¹	11.63	GATA3 PBX1 TP53
10	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Show member pathways Clozapine Pathway, Pharmacokinetics ⁶¹ Doxepin Pathway, Pharmacokinetics ⁶¹ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Gefitinib Pathway, Pharmacokinetics ⁶¹ Nevirapine Pathway, Pharmacokinetics ⁶¹ Pazopanib Pathway, Pharmacokinetics ⁶¹ Warfarin Pathway, Pharmacokinetics ⁶¹	11.59	ABL1 BCR PDGFRA
11	Transcriptional misregulation in cancer ³⁷	11.55	AFF1 ETV6 FLT3 KMT2A PAX5 PBX1
12	Central carbon metabolism in cancer ³⁷	11.5	FLT3 PDGFRA TP53
13	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.38	CDKN2A PDGFRA TP53
14	Inhibition of Ribosome Biogenesis by p14(ARF) ⁶⁴	10.84	ABL1 CDKN2A TP53
15	TP53 Network ¹ Show member pathways Activation, translocation and oligomerization of BAX ⁶⁶	10.78	ABL1 CDKN2A TP53

Sources

GO Terms for Leukemia, Acute Lymphoblastic 3

Cellular components related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.7	ABL1 CDKN2A FOXP1 GATA3 KMT2A PAX5
2	nucleus	GO:0005634	9.55	ABL1 AFF1 AUTS2 CDKN2A ETV6 FLT3

Biological processes related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell differentiation	GO:0030154	9.97	ABL1 ETV6 FLT3 PAX5 PBX1 PDGFRA
2	positive regulation of transcription, DNA-templated	GO:0045893	9.95	CDKN2A GATA3 KMT2A RUNX1 TCF3 TP53
3	regulation of transcription, DNA-templated	GO:0006355	9.93	ABL1 AFF1 ETV6 FOXP1 GATA3 HLF
4	transcription by RNA polymerase II	GO:0006366	9.86	ETV6 GATA3 HLF KMT2A PAX5 PBX1
5	peptidyl-tyrosine phosphorylation	GO:0018108	9.83	ABL1 BCR FLT3 PDGFRA
6	protein autophosphorylation	GO:0046777	9.8	ABL1 BCR FLT3 PDGFRA
7	animal organ morphogenesis	GO:0009887	9.73	GATA3 PAX5 PBX1 PDGFRA
8	positive regulation of transcription by RNA polymerase II	GO:0045944	9.7	AUTS2 CDKN2A ETV6 GATA3 HLF KMT2A
9	positive regulation of endothelial cell migration	GO:0010595	9.69	ABL1 FOXP1 GATA3
10	thymus development	GO:0048538	9.63	ABL1 GATA3 PBX1
11	regulation of actin cytoskeleton reorganization	GO:2000249	9.6	ABL1 PDGFRA
12	positive regulation of histone H3-K4 methylation	GO:0051571	9.59	AUTS2 KMT2A
13	hematopoietic stem cell proliferation	GO:0071425	9.58	ETV6 RUNX1
14	replicative senescence	GO:0090399	9.58	CDKN2A TP53
15	platelet-derived growth factor receptor signaling pathway	GO:0048008	9.58	ABL1 BCR PDGFRA
16	cell activation	GO:0001775	9.57	GATA3 PDGFRA
17	regulation of B cell receptor signaling pathway	GO:0050855	9.56	PAX5 RUNX1
18	negative regulation of ubiquitin-protein transferase activity	GO:0051444	9.54	ABL1 CDKN2A
19	embryonic hemopoiesis	GO:0035162	9.5	GATA3 KMT2A PBX1
20	regulation of hematopoietic stem cell differentiation	GO:1902036	9.02	ABL1 GATA3 KMT2A RUNX1 TCF3
21	negative regulation of transcription by RNA polymerase II	GO:0000122	10.02	ETV6 GATA3 PAX5 RUNX1 TCF3 TP53

Molecular functions related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	9.96	ETV6 FOXP1 GATA3 HLF KMT2A PAX5
2	transcription regulatory region DNA binding	GO:0044212	9.8	GATA3 KMT2A RUNX1 TP53
3	proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001077	9.77	ETV6 GATA3 HLF PAX5 PBX1
4	DNA binding	GO:0003677	9.73	ABL1 CDKN2A ETV6 FOXP1 GATA3 HLF
5	RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	9.72	ETV6 GATA3 HLF PBX1 RUNX1
6	protein tyrosine kinase activity	GO:0004713	9.71	ABL1 BCR FLT3 PDGFRA
7	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	9.7	ETV6 GATA3 PAX5 PBX1 RUNX1 TCF3
8	protein self-association	GO:0043621	9.61	FLT3 FOXP1 TP53
9	vascular endothelial growth factor-activated receptor activity	GO:0005021	9.46	FLT3 PDGFRA
10	DNA-binding transcription factor activity	GO:0003700	9.36	AFF1 ETV6 FOXP1 GATA3 HLF KMT2A
11	protein binding	GO:0005515	10.41	ABL1 AFF1 AUTS2 BCR CDKN2A ETV6

Sources

Sources for Leukemia, Acute Lymphoblastic 3

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Leukemia, Acute Lymphoblastic 3 (ALL3)

Aliases & Classifications for Leukemia, Acute Lymphoblastic 3

MalaCards integrated aliases for Leukemia, Acute Lymphoblastic 3:

Classifications:

External Ids:

Summaries for Leukemia, Acute Lymphoblastic 3

Related Diseases for Leukemia, Acute Lymphoblastic 3

Diseases in the Leukemia, Acute Lymphoblastic family:

Diseases related to Leukemia, Acute Lymphoblastic 3 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Leukemia, Acute Lymphoblastic 3:

Symptoms & Phenotypes for Leukemia, Acute Lymphoblastic 3

Clinical features from OMIM:

UMLS symptoms related to Leukemia, Acute Lymphoblastic 3:

GenomeRNAi Phenotypes related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to Leukemia, Acute Lymphoblastic 3:

Drugs & Therapeutics for Leukemia, Acute Lymphoblastic 3

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Genetic Tests for Leukemia, Acute Lymphoblastic 3

Genetic tests related to Leukemia, Acute Lymphoblastic 3:

Anatomical Context for Leukemia, Acute Lymphoblastic 3

MalaCards organs/tissues related to Leukemia, Acute Lymphoblastic 3:

Publications for Leukemia, Acute Lymphoblastic 3

Articles related to Leukemia, Acute Lymphoblastic 3:

Genes for Leukemia, Acute Lymphoblastic 3

Genes related to Leukemia, Acute Lymphoblastic 3 (20 elite genes):

Variations for Leukemia, Acute Lymphoblastic 3

ClinVar genetic disease variations for Leukemia, Acute Lymphoblastic 3:

Expression for Leukemia, Acute Lymphoblastic 3

Pathways for Leukemia, Acute Lymphoblastic 3

Pathways related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

GO Terms for Leukemia, Acute Lymphoblastic 3

Cellular components related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

Biological processes related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

Molecular functions related to Leukemia, Acute Lymphoblastic 3 according to GeneCards Suite gene sharing:

Sources for Leukemia, Acute Lymphoblastic 3

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :