MCID: LKM070
MIFTS: 55

Leukemia, Acute Monocytic

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Leukemia, Acute Monocytic

MalaCards integrated aliases for Leukemia, Acute Monocytic:

Name: Leukemia, Acute Monocytic 57 38
Acute Monocytic Leukemia 38 12 76 29 55 15 73
Acute Monoblastic Leukemia and Acute Monocytic Leukemia 12
Acute Monocytic Leukemia Without Mention of Remission 12
M5b Acute Differentiated Monocytic Leukemia 73
Acute Monocytic Leukemia, Morphology 12
Acute Monocytic Leukemia, Fab M5 12
Leukemia, Monocytic, Acute 44

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant somatic cell mutation


HPO:

32
leukemia, acute monocytic:
Inheritance autosomal dominant somatic cell mutation


Classifications:



External Ids:

OMIM 57 151380
Disease Ontology 12 DOID:8864
ICD9CM 35 206.0
MeSH 44 D007948
MedGen 42 C0023465

Summaries for Leukemia, Acute Monocytic

MalaCards based summary : Leukemia, Acute Monocytic, also known as acute monocytic leukemia, is related to monocytic leukemia and leukemia, acute myeloid. An important gene associated with Leukemia, Acute Monocytic is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1
Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia.
Dysfunction Pattern: Regulation [up-regulated]), and among its related pathways/superpathways are Tuberculosis and Cellular response to heat stress. The drugs Busulfan and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include myeloid, monocytes and bone, and related phenotypes are acute monocytic leukemia and growth/size/body region

Wikipedia : 76 Acute monocytic leukemia (AMoL, or AML-M5) is considered a type of acute myeloid... more...

Description from OMIM: 151380

Related Diseases for Leukemia, Acute Monocytic

Diseases in the Monocytic Leukemia family:

Leukemia, Acute Monocytic Adult Acute Monocytic Leukemia
Chronic Monocytic Leukemia Subacute Monocytic Leukemia

Diseases related to Leukemia, Acute Monocytic via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 monocytic leukemia 29.8 CD14 KAT6A KIAA0100 KMT2A
2 leukemia, acute myeloid 25.8 AFDN KAT6A KMT2A MALAT1 MLLT10 MLLT3
3 adult acute monocytic leukemia 12.6
4 acute monoblastic leukemia 11.4
5 acute myeloid leukemia with t(8;16)(p11;p13) translocation 10.5 CREBBP KAT6A
6 mn1 10.3 EP300 KMT2A
7 rubinstein-taybi syndrome 1 10.2 CREBBP EP300
8 acute biphenotypic leukemia 10.2 KMT2A MLLT10 MPO
9 leukemia 10.2
10 myeloid sarcoma 10.2 KMT2A MPO
11 human t-cell leukemia virus type 2 10.2 CREBBP EP300
12 acute myeloid leukemia with t(9;11)(p22;q23) 10.1 KMT2A MLLT3
13 chromosome 16p13.3 deletion syndrome, proximal 10.1 CREBBP EP300 KAT6A
14 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 CREBBP KMT2A MPO
15 human t-cell leukemia virus type 1 9.9 CREBBP EP300
16 myeloid leukemia 9.8
17 precursor t-cell acute lymphoblastic leukemia 9.8 KMT2A MLLT10 MPO NUP98
18 hypoxia 9.8 CREBBP EP300 KMT2A
19 leukemia, chronic lymphocytic 2 9.7
20 leukemia, chronic lymphocytic 9.7
21 leukemia, b-cell, chronic 9.7
22 leukemia, chronic myeloid 9.5 KMT2A MPO NUP98
23 hematologic cancer 9.3 CREBBP EP300 KMT2A MLLT10 NUP98
24 acute leukemia 9.1 CREBBP KMT2A MLLT10 MLLT3 MPO
25 neonatal leukemia 9.0 CREBBP EP300 KAT6A MLLT10 MLLT3

Graphical network of the top 20 diseases related to Leukemia, Acute Monocytic:



Diseases related to Leukemia, Acute Monocytic

Symptoms & Phenotypes for Leukemia, Acute Monocytic

Symptoms via clinical synopsis from OMIM:

57
Heme:
acute monocytic leukemia


Clinical features from OMIM:

151380

Human phenotypes related to Leukemia, Acute Monocytic:

32
# Description HPO Frequency HPO Source Accession
1 acute monocytic leukemia 32 HP:0004845

MGI Mouse Phenotypes related to Leukemia, Acute Monocytic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 AFDN CD14 CREBBP EP300 KAT6A KMT2A
2 embryo MP:0005380 9.97 AFDN CREBBP EP300 KAT6A KMT2A MLLT3
3 hematopoietic system MP:0005397 9.86 CD14 CREBBP EP300 KAT6A KMT2A MLLT3
4 immune system MP:0005387 9.76 NUP98 CD14 CREBBP EP300 KAT6A KMT2A
5 mortality/aging MP:0010768 9.65 CD14 CREBBP EP300 KAT6A KMT2A MLLT3
6 neoplasm MP:0002006 9.02 CREBBP EP300 KMT2A MLLT3 NME1

Drugs & Therapeutics for Leukemia, Acute Monocytic

Drugs for Leukemia, Acute Monocytic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 217)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
3
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4 6253
4
Daunorubicin Approved Phase 3,Phase 2,Phase 1 20830-81-3 30323
5
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
6
Idarubicin Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58957-92-9 42890
7
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
8
Mesna Approved, Investigational Phase 3 3375-50-6 598
9
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
10
Aldesleukin Approved Phase 3,Phase 1,Phase 2 85898-30-2, 110942-02-4
11
Amsacrine Approved, Investigational Phase 3 51264-14-3 2179
12
Thioguanine Approved Phase 3,Phase 1 154-42-7 2723601
13
Clofarabine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 123318-82-1 119182
14
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
15
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
16
Fludarabine Approved Phase 3,Phase 2,Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751
17
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
18
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
19
alemtuzumab Approved, Investigational Phase 2, Phase 3,Phase 1 216503-57-0
20
Arsenic trioxide Approved, Investigational Phase 2, Phase 3,Phase 1 1327-53-3 518740
21
Azacitidine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 320-67-2 9444
22
Melphalan Approved Phase 2, Phase 3,Phase 3,Phase 1 148-82-3 4053 460612
23
Carmustine Approved, Investigational Phase 3 154-93-8 2578
24
Hydroxyurea Approved Phase 3 127-07-1 3657
25
Decitabine Approved, Investigational Phase 3,Phase 2,Phase 1 2353-33-5 451668
26
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
27
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
28
Cyproheptadine Approved Phase 3 129-03-3 2913
29
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
30
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2,Phase 1 302-79-4 5538 444795
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
32
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1 58-05-9 143 6006
33
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
34
tipifarnib Investigational Phase 3,Phase 2,Phase 1 192185-72-1 159324
35 Staurosporine Experimental Phase 3,Phase 1 62996-74-1
36 Vaccines Phase 3,Phase 1
37 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
38 Analgesics Phase 3,Phase 2,Phase 1
39 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
45 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
46 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
47 Antiviral Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Etoposide phosphate Phase 3,Phase 2,Phase 1
49 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 188)
# Name Status NCT ID Phase Drugs
1 Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia in Remission Unknown status NCT00454168 Phase 3
2 Combination Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00002549 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mesna;mitoxantrone hydrochloride
3 Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
4 Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Patients With Refractory or Relapsed Acute Myelogenous Leukemia Unknown status NCT00006045 Phase 3 cytarabine;etoposide;mitoxantrone hydrochloride
5 Combination Chemotherapy, Interleukin-2, and Peripheral Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00004128 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide
6 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
7 Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00006363 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar;busulfan
8 Combination Chemotherapy With or Without Valspodar in Treating Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00003190 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;valspodar
9 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome Completed NCT00002798 Phase 3 asparaginase;daunorubicin hydrochloride;fludarabine phosphate;therapeutic hydrocortisone;cytarabine;idarubicin;dexamethasone;thioguanine;etoposide;methotrexate;cyclophosphamide;busulfan
10 Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00369317 Phase 3 asparaginase;daunorubicin hydrochloride;cytarabine;thioguanine;etoposide
11 Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00372593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;etoposide;gemtuzumab ozogamicin;mitoxantrone hydrochloride
12 Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia Completed NCT00005863 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;tretinoin
13 Tipifarnib in Treating Patients With Acute Myeloid Leukemia in Remission Completed NCT00093470 Phase 3 Tipifarnib
14 Cytarabine and Daunorubicin With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes Completed NCT00121303 Phase 3 cytarabine;daunorubicin hydrochloride;gemtuzumab ozogamicin
15 Chemotherapy With or Without Gemtuzumab Ozogamicin in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00052299 Phase 3 cytarabine;etoposide;gemtuzumab ozogamicin;idarubicin;mitoxantrone hydrochloride
16 Daunorubicin & Cytarabine +/- Zosuquidar inTreating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or Refractory Anemia Completed NCT00046930 Phase 3 cytarabine;daunorubicin hydrochloride;zosuquidar trihydrochloride;Placebo
17 S0106 Cytarabine and Daunorubicin w/ or w/o Gemtuzumab Followed By HD Cytarabine and Either Gemtuzumab or Nothing in de Novo AML Completed NCT00085709 Phase 3 gemtuzumab ozogamicin;Cytosine arabinoside;Daunomycin
18 Combination Chemotherapy With or Without Gemtuzumab Ozogamicin or Tipifarnib in Treating Patients With Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes Completed NCT00454480 Phase 2, Phase 3 arsenic trioxide;azacitidine;busulfan;clofarabine;cytarabine;daunorubicin hydrochloride;fludarabine phosphate;gemtuzumab ozogamicin;melphalan;tipifarnib
19 Cytarabine With or Without VNP40101M in Treating Patients With Relapsed Acute Myeloid Leukemia Completed NCT00112554 Phase 3 cytarabine;laromustine
20 Combination Chemotherapy With or Without G-CSF in Treating Older Patients With Acute Myeloid Leukemia Completed NCT00002719 Phase 3 amsacrine;carmustine;cytarabine;etoposide;idarubicin;mitoxantrone hydrochloride
21 flt3L in Treating Patients With Acute Myeloid Leukemia Completed NCT00006223 Phase 3
22 Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00005823 Phase 3 cytarabine;daunorubicin hydrochloride;etoposide;hydroxyurea;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin;valspodar
23 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome Completed NCT00002517 Phase 3 cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine
24 Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome Completed NCT00003593 Phase 3 asparaginase;cytarabine;daunorubicin hydrochloride;methotrexate;therapeutic hydrocortisone;thioguanine
25 High Dose Chemotherapy, Peripheral Stem Cell Transplantation, and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia Completed NCT00002945 Phase 3 cyclophosphamide;cytarabine;etoposide;idarubicin;melphalan
26 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3 caspofungin acetate;fluconazole
27 Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT02085408 Phase 3 clofarabine;daunorubicin hydrochloride;cytarabine;decitabine
28 Daunorubicin, Cytarabine, and Midostaurin in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Active, not recruiting NCT00651261 Phase 3 cytarabine;daunorubicin;midostaurin;dexamethasone acetate
29 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
30 Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant Unknown status NCT02038153 Phase 1, Phase 2 Lenalidomide
31 Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00003405 Phase 2 amifostine trihydrate;bromodeoxyuridine;cytarabine;idarubicin;idoxuridine;isotretinoin;mitoxantrone hydrochloride
32 Clofarabine, Cytarabine, and Idarubicin in Treating Patients With Intermediate-Risk or High-Risk Acute Myeloid Leukemia or High-Risk Myelodysplasia Unknown status NCT00838240 Phase 1, Phase 2 clofarabine;cytarabine;idarubicin
33 VNP40101M Followed by Cytarabine in Treating Older Patients With Acute Myeloid Leukemia Unknown status NCT00354276 Phase 2 cytarabine;laromustine
34 Bexarotene and GM-CSF in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Unknown status NCT00425477 Phase 2 bexarotene
35 Monoclonal Antibody in Treating Patients With Acute Myelogenous Leukemia Unknown status NCT00006084 Phase 2
36 Combination Chemotherapy in Treating Patients With Relapsed Acute Myelogenous Leukemia Unknown status NCT00003758 Phase 2 cytarabine;idarubicin
37 Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia Completed NCT00666588 Phase 2 idarubicin;cytarabine;bortezomib;etoposide
38 High-Dose Busulfan and High-Dose Cyclophosphamide Followed By Donor Bone Marrow Transplant in Treating Patients With Leukemia, Myelodysplastic Syndrome, Multiple Myeloma, or Recurrent Hodgkin or Non-Hodgkin Lymphoma Completed NCT01177371 Phase 2 busulfan;cyclophosphamide;methylprednisolone;methotrexate;cyclosporine
39 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
40 Cytarabine With or Without SCH 900776 in Treating Adult Patients With Relapsed Acute Myeloid Leukemia Completed NCT01870596 Phase 2 Cytarabine;CHK1 Inhibitor SCH 900776
41 Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia Completed NCT01361464 Phase 2 Tipifarnib
42 Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia Completed NCT01168219 Phase 2 Azacitidine;Busulfan;Fludarabine Phosphate;Methotrexate;Tacrolimus
43 Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00027872 Phase 2 tipifarnib
44 Choline Magnesium Trisalicylate and Combination Chemotherapy in Treating Patients With Acute Myeloid Leukemia Completed NCT02144675 Phase 2 choline magnesium trisalicylate;idarubicin;cytarabine
45 Alvocidib, Cytarabine, and Mitoxantrone Hydrochloride or Cytarabine and Daunorubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT01349972 Phase 2 alvocidib;daunorubicin hydrochloride;mitoxantrone hydrochloride;cytarabine
46 AKT Inhibitor MK-2206 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT01253447 Phase 2 Akt inhibitor MK2206
47 Early Discharge and Outpatients Care in Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia Previously Treated With Intensive Chemotherapy Completed NCT01235572 Phase 2
48 Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML Completed NCT00895934 Phase 1, Phase 2 vorinostat;gemtuzumab ozogamicin;azacitidine
49 Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed NCT00634244 Phase 2 alvocidib;mitoxantrone hydrochloride;carboplatin;cytarabine;sirolimus;etoposide;topotecan hydrochloride
50 Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Completed NCT00795002 Phase 2 alvocidib;mitoxantrone hydrochloride;cytarabine

Search NIH Clinical Center for Leukemia, Acute Monocytic

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Acute Monocytic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Leukemia, Acute Monocytic:
NiCord
Embryonic/Adult Cultured Cells Related to Leukemia, Acute Monocytic:
Umbilical cord blood-derived stem cells (NiCord) PMIDs: 22198152

Cochrane evidence based reviews: leukemia, monocytic, acute

Genetic Tests for Leukemia, Acute Monocytic

Genetic tests related to Leukemia, Acute Monocytic:

# Genetic test Affiliating Genes
1 Acute Monocytic Leukemia 29

Anatomical Context for Leukemia, Acute Monocytic

MalaCards organs/tissues related to Leukemia, Acute Monocytic:

41
Myeloid, Monocytes, Bone, Bone Marrow, Lung, Prostate, Skin

Publications for Leukemia, Acute Monocytic

Articles related to Leukemia, Acute Monocytic:

(show top 50) (show all 273)
# Title Authors Year
1
Anti-Cancerous Effect of Inonotus taiwanensis Polysaccharide Extract on Human Acute Monocytic Leukemia Cells through ROS-Independent Intrinsic Mitochondrial Pathway. ( 29382173 )
2018
2
Trisomy 6 as the sole stemline abnormality in a patient with acute monocytic leukemia: a case report. ( 29755835 )
2018
3
Dihydroartemisinin-induced apoptosis in human acute monocytic leukemia cells. ( 29435054 )
2018
4
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations. ( 29843647 )
2018
5
Acute monocytic leukemia diagnosed by flow cytometry includes acute myeloid leukemias with weakly or faintly positive non-specific esterase staining. ( 29721252 )
2018
6
Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. ( 28108519 )
2017
7
Duplication of subtelomeric regions in an adult with acute monocytic leukemia with an acquired jumping translocation involving 3q13.31-qter. ( 28725672 )
2017
8
Cutaneous presentation preceding acute monocytic leukemia: A CARE-compliant article. ( 28272239 )
2017
9
Upregulation of long non-coding RNA MALAT-1 confers poor prognosis and influences cell proliferation and apoptosis in acute monocytic leukemia. ( 28713913 )
2017
10
5a89azaa892'a89deoxycytidine promotes migration of acute monocytic leukemia cells via activation of CCL2a89CCR2a89ERK signaling pathway. ( 28627644 )
2017
11
Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway. ( 28912858 )
2017
12
Characterization of an acquired jumping translocation involving 3q13.31-qter in a patient with de novo acute monocytic leukemia. ( 28625614 )
2017
13
Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress. ( 28270496 )
2017
14
Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy. ( 28634616 )
2017
15
Polydatin Induces Apoptosis and Inhibits Growth of Acute Monocytic Leukemia Cells. ( 26616494 )
2016
16
Leukemia cutis preceding bone marrow relapse in acute monocytic leukemia. ( 27643547 )
2016
17
Hypoxia inducible factor-1a regulates a pro-invasive phenotype in acute monocytic leukemia. ( 27447550 )
2016
18
Acute Monocytic Leukemia Masquerading BehAset's Disease-Like Illness at Onset in an Elderly Female. ( 27610252 )
2016
19
Spurious Thrombocytosis Caused by Tumor Cell Lysis in a Patient with Acute Monocytic Leukemia. ( 28164618 )
2016
20
Acute monocytic leukemia masked by hemolytic anemia and sclerotic lesions. ( 27572458 )
2016
21
Histiocytic differentiation in acute monocytic leukemia. ( 26771450 )
2016
22
Knockdown of p54nrb inhibits migration, invasion and TNF-I+ release of human acute monocytic leukemia THP1 cells. ( 27108701 )
2016
23
The Successful Complete Remission Induction by Sorafenib Monotherapy in a FLT3-D835Y-Positive Patient with Refractory Acute Monocytic Leukemia. ( 27408351 )
2016
24
Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells. ( 26708503 )
2016
25
Generation of a MLL-AF9-specific stem cell model of acute monocytic leukemia. ( 27185517 )
2016
26
Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells. ( 25973292 )
2015
27
Ara-C and anti-CD47 antibody combination therapy eliminates acute monocytic leukemia THP-1 cells in vivo and in vitro. ( 26125761 )
2015
28
Histiocytic sarcoma combined with acute monocytic leukemia: a case report. ( 26187047 )
2015
29
Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells. ( 26136223 )
2015
30
Induction with azacytidine followed by allogeneic hematopoietic stem cell transplantation in a Jehovah's Witness with acute monocytic leukemia. ( 25984306 )
2015
31
A case of extramedullary involvement of acute monocytic leukemia that presented as obstructive jaundice. ( 26422978 )
2015
32
Posterior reversible encephalopathy syndrome following acute pancreatitis during chemotherapy for acute monocytic leukemia. ( 24881921 )
2014
33
Spontaneous regression of cutaneous blastic plasmacytoid dendritic cell neoplasm followed by acute monocytic leukemia evolving from myelodysplastic syndrome. ( 25447656 )
2014
34
Secondary acute monocytic leukemia positive for 11q23 rearrangement in Nijmegen breakage syndrome. ( 24619942 )
2014
35
Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report. ( 24396488 )
2014
36
Antiproliferative activities of lesser galangal (Alpinia officinarum Hance Jam1), turmeric (Curcuma longa L.), and ginger (Zingiber officinale Rosc.) against acute monocytic leukemia. ( 23819642 )
2013
37
Leukemia cutis in a patient with acute monocytic leukemia diagnosed simultaneously with hepatocellular carcinoma: A case study. ( 24179516 )
2013
38
Sorting, identification and enrichment of side population cells in THP-1 acute monocytic leukemia cells. ( 23450319 )
2013
39
Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1I+ signaling. ( 24064771 )
2013
40
Regulated cellular exposure to non-thermal plasma allows preferentially directed apoptosis in acute monocytic leukemia cells. ( 23400198 )
2013
41
Bryostatin 5 induces apoptosis in acute monocytic leukemia cells by activating PUMA and caspases. ( 24036350 )
2013
42
Effect of RNAi-induced down regulation of nuclear factor kappa-B p65 on acute monocytic leukemia THP-1 cells in vitro and vivo. ( 21901538 )
2012
43
Role of misfolded N-CoR mediated transcriptional deregulation of Flt3 in acute monocytic leukemia (AML)-M5 subtype. ( 22514634 )
2012
44
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia. ( 23037626 )
2012
45
A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic leukemia cell line. ( 23299097 )
2012
46
Jumping translocations of 3q21 in an acute monocytic leukemia (M5) patient reveal mechanisms of multistage telomere shortening in pathogenesis of AML. ( 21983177 )
2012
47
Heterogeneous leukemic clones identified by NPM1 mutation analysis in patient with acute monocytic leukemia. ( 22035378 )
2012
48
Fatal bronchial invasion of Scopulariopsis brevicaulis in an acute monocytic leukemia patient. ( 22633337 )
2012
49
Mutations inDNMT3A and loss of RKIP are independent events in acute monocytic leukemia. ( 22875620 )
2012
50
Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. ( 21605636 )
2011

Variations for Leukemia, Acute Monocytic

Copy number variations for Leukemia, Acute Monocytic from CNVD:

7 (show all 23)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21832 1 16200000 20400000 Gain Acute monocytic leukemia
2 31525 1 28000000 30200000 Gain Acute monocytic leukemia
3 61776 12 10100000 12800000 Loss Acute monocytic leukemia
4 90243 15 20700000 25700000 Gain Acute monocytic leukemia
5 93369 15 52900000 59100000 Gain Acute monocytic leukemia
6 108855 17 23200000 28800000 Deletion NF1 Acute monocytic leukemia
7 110292 17 31800000 38100000 Gain Acute monocytic leukemia
8 116498 17 67100000 70900000 Loss Acute monocytic leukemia
9 125458 19 13900000 20000000 Gain Acute monocytic leukemia
10 133734 19 6900000 13900000 Gain Acute monocytic leukemia
11 140901 2 203300000 204900000 Loss Acute monocytic leukemia
12 188152 4 59500000 66600000 Loss Acute monocytic leukemia
13 190404 4 88000000 93700000 Loss Acute monocytic leukemia
14 191655 5 1 4500000 Gain Acute monocytic leukemia
15 196530 5 168500000 172800000 Gain Acute monocytic leukemia
16 201329 5 68400000 73300000 Gain Acute monocytic leukemia
17 206333 6 139000000 142800000 Loss Acute monocytic leukemia
18 219029 7 121100000 123800000 Loss Acute monocytic leukemia
19 224721 7 37200000 43300000 Loss Acute monocytic leukemia
20 226783 7 61700000 67000000 Loss Acute monocytic leukemia
21 226785 7 61700000 77500000 Loss Acute monocytic leukemia
22 243519 8 84600000 86900000 Gain Acute monocytic leukemia
23 250024 9 19900000 25600000 Loss Acute monocytic leukemia

Expression for Leukemia, Acute Monocytic

Search GEO for disease gene expression data for Leukemia, Acute Monocytic.

Pathways for Leukemia, Acute Monocytic

GO Terms for Leukemia, Acute Monocytic

Cellular components related to Leukemia, Acute Monocytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.28 AFDN CREBBP EP300 KAT6A KMT2A MLLT10
2 histone acetyltransferase complex GO:0000123 8.96 CREBBP EP300

Biological processes related to Leukemia, Acute Monocytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.77 CREBBP EP300 KAT6A KMT2A MLLT3
2 rhythmic process GO:0048511 9.58 CREBBP EP300 KMT2A
3 regulation of cellular response to heat GO:1900034 9.5 CREBBP EP300 NUP98
4 positive regulation of transcription of Notch receptor target GO:0007221 9.43 CREBBP EP300
5 positive regulation of type I interferon production GO:0032481 9.43 CD14 CREBBP EP300
6 histone acetylation GO:0016573 9.33 CREBBP EP300 KAT6A
7 N-terminal peptidyl-lysine acetylation GO:0018076 8.96 CREBBP EP300
8 protein acetylation GO:0006473 8.8 CREBBP EP300 KAT6A

Molecular functions related to Leukemia, Acute Monocytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.55 CREBBP EP300 KMT2A MLLT3 MPO
2 transferase activity, transferring acyl groups GO:0016746 9.54 CREBBP EP300 KAT6A
3 histone acetyltransferase activity GO:0004402 9.43 CREBBP EP300 KAT6A
4 lysine-acetylated histone binding GO:0070577 9.32 KMT2A MLLT3
5 peptide N-acetyltransferase activity GO:0034212 8.96 CREBBP EP300
6 acetyltransferase activity GO:0016407 8.8 CREBBP EP300 KAT6A

Sources for Leukemia, Acute Monocytic

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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