AML
MCID: LKM061
MIFTS: 83

Leukemia, Acute Myeloid (AML)

Categories: Blood diseases, Cancer diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Leukemia, Acute Myeloid

MalaCards integrated aliases for Leukemia, Acute Myeloid:

Name: Leukemia, Acute Myeloid 57 37
Acute Myeloid Leukemia 12 73 20 58 72 36 29 6 42 15 17
Leukemia, Acute Myelogenous 57 72 13 39
Acute Myelogenous Leukemia 12 73 20 58
Aml 57 58 72 3
Leukemia, Acute Myeloid, Susceptibility to 57 29 6
Acute Undifferentiated Leukemia 58 54 70
Acute Myeloblastic Leukemia 12 73 72
Leukemia, Acute Myeloid, Reduced Survival in, Somatic 57 6
Leukemia, Myelocytic, Acute 12 70
Acute Myelocytic Leukemia 73 72
Leukemia, Myeloid, Acute 44 39
Acute Myeloid Leukaemia 12 15
Secondary Aml 58 54
Therapy Related Acute Myeloid Leukemia and Myelodysplastic Syndrome 58
Acute Myeloid Leukaemia with Myelodysplasia-Related Features 58
Acute Myeloid Leukemia, Minimal Differentiation, Fab M0 58
Acute Myeloid Leukemia with Recurrent Genetic Anomaly 58
Acute Myeloid Leukemia with Cebpa Somatic Mutations 58
Acute Myeloid Leukemia with Multilineage Dysplasia 58
Myeloid Leukemia, Acute, M4/m4eo Subtype, Somatic 57
Therapy-Related Aml and Myelodysplastic Syndrome 58
Aml with Myelodysplasia-Related Features 58
Acute Leukemia of Indeterminate Lineage 58
Pure Familial Acute Myeloid Leukemia 58
Acute Leukemia of Ambiguous Lineage 58
Unclassified Acute Myeloid Leukemia 58
Aml with Recurrent Genetic Anomaly 58
Leukemia, Acute Myeloid, Somatic 57
Aml with Cebpa Somatic Mutations 58
Inherited Acute Myeloid Leukemia 58
Secondary Acute Myeloid Leukemia 58
Acute Non-Lymphoblastic Leukemia 72
Acute Myeloid Leukemia, Somatic 57
Aml with Multilineage Dysplasia 58
Mixed Phenotype Acute Leukemia 58
Acute Non-Lymphocytic Leukemia 72
Acute Myeloblastic Leukaemia 12
Aml - Acute Myeloid Leukemia 12
Mixed Lineage Acute Leukemia 58
Acute Myelogenous Leukaemia 12
Acute Biphenotypic Leukemia 70
Hybrid Acute Leukemia 58
Pure Familial Aml 58
Unclassified Aml 58
Inherited Aml 58
Familial Aml 58
Mpal 58

Characteristics:

Orphanet epidemiological data:

58
acute myeloid leukemia
Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Europe),1-5/10000 (Europe),1-9/100000 (France),1-9/100000 (Denmark),1-9/100000 (United States); Age of onset: All ages; Age of death: any age;
acute leukemia of ambiguous lineage
Age of onset: All ages;

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
somatic mutation
autosomal dominant

Miscellaneous:
evidence of anticipation
mean onset age 57 years, 32 years and 13 years in successive generations
many genes with somatic mutation


HPO:

31
leukemia, acute myeloid:
Inheritance autosomal dominant inheritance somatic mutation


Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:9119
OMIM® 57 601626
KEGG 36 H00003
ICD9CM 34 205.0
MeSH 44 D015470
NCIt 50 C3171
SNOMED-CT 67 91861009
MESH via Orphanet 45 D015456 D015470
ICD10 via Orphanet 33 C92.0 C92.8 C95.0
UMLS via Orphanet 71 C0023464 C0023467 C0280141 more
UMLS 70 C0023464 C0023467 C0280141

Summaries for Leukemia, Acute Myeloid

MedlinePlus : 42 What is leukemia? Leukemia is a term for cancers of the blood cells. Leukemia starts in blood-forming tissues such as the bone marrow. Your bone marrow makes the cells which will develop into white blood cells, red blood cells, and platelets. Each type of cell has a different job: White blood cells help your body fight infection Red blood cells deliver oxygen from your lungs to your tissues and organs Platelets help form clots to stop bleeding When you have leukemia, your bone marrow makes large numbers of abnormal cells. This problem most often happens with white blood cells. These abnormal cells build up in your bone marrow and blood. They crowd out the healthy blood cells and make it hard for your cells and blood to do their work. What is acute myeloid leukemia (AML)? Acute myeloid leukemia (AML) is a type of acute leukemia. "Acute" means that the leukemia usually gets worse quickly if it's not treated. In AML, the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. When the abnormal cells crowd out the healthy cells, it can lead to infection, anemia, and easy bleeding. The abnormal cells can also spread outside the blood to other parts of the body. There are several different subtypes of AML. The subtypes are based on how developed the cancer cells are when you get your diagnosis and how different they are from normal cells. What causes acute myeloid leukemia (AML)? AML happens when there are changes in the genetic material (DNA) in bone marrow cells. The cause of these genetic changes is unknown. However, there are certain factors that raise your risk of AML. Who is at risk for acute myeloid leukemia (AML)? The factors that raise your risk of AML include Being male Smoking, especially after age 60 Having had chemotherapy or radiation therapy Treatment for acute lymphoblastic leukemia (ALL) as a child Exposure to the chemical benzene A history of another blood disorder such as myelodysplastic syndrome What are the symptoms of acute myeloid leukemia (AML)? The signs and symptoms of AML include Fever Shortness of breath Easy bruising or bleeding Petechiae, which are tiny red dots under the skin. They are caused by bleeding. Weakness or feeling tired Weight loss or loss of appetite Bone or joint pain, if the abnormal cells build up near or inside the bones How is acute myeloid leukemia (AML) diagnosed? Your health care provider may use many tools to diagnose AML and figure out which subtype you have: A physical exam A medical history Blood tests, such as a complete blood count (CBC) and blood smear Bone marrow tests. There are two main types - bone marrow aspiration and bone marrow biopsy. Both tests involve removing a sample of bone marrow and bone. The samples are sent to a lab for testing. Genetic tests to look for gene and chromosome changes If you are diagnosed with AML, you may have additional tests to see whether the cancer has spread. These include imaging tests and a lumbar puncture, which is a procedure to collect and test cerebrospinal fluid (CSF). What are the treatments for acute myeloid leukemia (AML)? Treatments for AML include Chemotherapy Radiation therapy Chemotherapy with stem cell transplant Other anticancer medicines Which treatment you get often depends on which subtype of AML you have. Treatment is usually done in two phases: The goal of the first phase is to kill the leukemia cells in the blood and bone marrow. This puts the leukemia into remission. Remission means that the signs and symptoms of cancer are reduced or have disappeared. The second phase is known as post-remission therapy. Its goal is to prevent a relapse (return) of the cancer. It involves killing any remaining leukemia cells that may not be active but could begin to regrow. NIH: National Cancer Institute

MalaCards based summary : Leukemia, Acute Myeloid, also known as acute myeloid leukemia, is related to leukemia and acute megakaryocytic leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Acute Myeloid is CEBPA (CCAAT Enhancer Binding Protein Alpha), and among its related pathways/superpathways are Acute myeloid leukemia and Transcriptional misregulation in cancer. The drugs Nicotine and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are acute myeloid leukemia and Decreased viability

Disease Ontology : 12 A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.

GARD : 20 Acute myeloid leukemia (AML) is a cancer that affects the blood and bone marrow. Conditions are generally called "acute" when they develop quickly and have an aggressive course. The signs and symptoms of AML vary but may include easy bruising; bone pain or tenderness; fatigue ; fever; frequent nosebleeds; bleeding from the gums; shortness of breath; and/or weightloss. AML is one of the most common types of leukemia among adults and is rarely diagnosed in people under age 40. There are many potential causes of AML such as certain blood disorders, inherited syndromes, environmental exposures, and drug exposures; however, most people who develop AML have no identifiable risk factor. Treatment may include a combination of chemotherapy, radiation therapy, bone marrow transplant and/or other drug therapy.

CDC : 3 Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig's disease, is a progressive disease that attacks the nerve cells that control voluntary movement. The National ALS Registry is a congressionally mandated registry for persons in the U.S. with ALS. It is the only population-based registry in the U.S. that collects information to help scientists learn more about who gets ALS and its causes. No one knows for sure what causes ALS and currently there is no cure.

KEGG : 36 Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as PML-RARalpha (in Acute promyelocytic leukemia, a subtype of AML), AML-ETO or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated.

UniProtKB/Swiss-Prot : 72 Leukemia, acute myelogenous: A subtype of acute leukemia, a cancer of the white blood cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils, eosinophils and monocytes.

Wikipedia : 73 Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid... more...

More information from OMIM: 601626

Related Diseases for Leukemia, Acute Myeloid

Diseases in the Myeloid Leukemia family:

Leukemia, Acute Myeloid Leukemia, Chronic Myeloid
Subacute Myeloid Leukemia Acute Myeloid Leukemia with T(9;11)(p22;q23)
Acute Myeloid Leukemia with T(6;9)(p23;q34) Acute Myeloid Leukemia with T(9;22)(q34.1;q11.2)

Diseases related to Leukemia, Acute Myeloid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1359)
# Related Disease Score Top Affiliating Genes
1 leukemia 34.4 TP53 TERT SH3GL1 RUNX1 PICALM NPM1
2 acute megakaryocytic leukemia 33.8 TP53 RUNX1 NPM1 MLLT10 KIT JAK2
3 core binding factor acute myeloid leukemia 33.8 RUNX1 KRAS KIT JAK2 FLT3 CEBPA
4 cytogenetically normal acute myeloid leukemia 33.5 NPM1 IDH2 FLT3 CEBPA
5 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 33.3 RUNX1 KIT FLT3 ETV6
6 myeloid leukemia 33.3 TP53 TERT SH3GL1 RUNX1 PICALM NUP214
7 mixed phenotype acute leukemia with t 33.3 RUNX1 DNMT3A
8 acute leukemia 33.2 RUNX1 NPM1 MLLT10 KRAS KIT JAK2
9 cebpa-associated familial acute myeloid leukemia 33.0 TERT SH3GL1 RUNX1 PICALM NUP214 NPM1
10 acute myeloblastic leukemia without maturation 32.8 NPM1 FLT3
11 acute myeloid leukemia with t(8;21)(q22;q22) translocation 32.7 RUNX1 KIT FLT3 CEBPA
12 diamond-blackfan anemia 32.7 TP53 TERT NPM1 JAK2 GATA2
13 thrombocytopenia 32.6 TERT RUNX1 NPM1 KRAS KIT JAK2
14 mixed phenotype acute leukemia 32.6 RUNX1 FLT3 DNMT3A
15 etv6 thrombocytopenia and predisposition to leukemia 32.5 TERT SH3GL1 RUNX1 PICALM NUP214 NPM1
16 childhood leukemia 32.5 TP53 RUNX1 ETV6
17 childhood acute myeloid leukemia 32.5 NPM1 KIT IDH2 FLT3 DNMT3A
18 shwachman-diamond syndrome 1 32.4 TP53 TERT GATA2
19 chronic myelomonocytic leukemia 32.4 TP53 RUNX1 NPM1 KRAS KIT JAK2
20 myelofibrosis 32.4 TP53 RUNX1 NPM1 KIT JAK2 IDH2
21 myelodysplastic syndrome 32.2 TP53 TERT RUNX1 NUP214 NPM1 KRAS
22 leukemia, acute lymphoblastic 32.1 TP53 RUNX1 PICALM NUP214 MLLT10 KRAS
23 myeloproliferative neoplasm 32.1 RUNX1 KIT JAK2 FLT3 ETV6 DNMT3A
24 bone marrow cancer 32.1 TP53 NPM1 KIT JAK2 IDH2 GATA2
25 myelodysplastic/myeloproliferative neoplasm 32.0 KIT JAK2 FLT3 ETV6 DNMT3A
26 wilms tumor 1 32.0 TP53 TERT NPM1 KRAS FLT3 CEBPA
27 myeloma, multiple 32.0 TP53 KRAS KIT JAK2 IDH2 FLT3
28 hematologic cancer 31.9 RUNX1 PICALM NPM1 MLLT10 KIT JAK2
29 monocytic leukemia 31.9 RUNX1 MLLT10 FLT3
30 blood platelet disease 31.9 TP53 RUNX1 KIT JAK2 FLT3
31 pancytopenia 31.8 TP53 TERT RUNX1 KIT
32 gastrointestinal stromal tumor 31.8 TP53 KRAS KIT JAK2 FLT3
33 atypical chronic myeloid leukemia 31.8 RUNX1 JAK2 FLT3 ETV6
34 myeloid sarcoma 31.8 NPM1 KIT FLT3
35 juvenile myelomonocytic leukemia 31.7 TP53 RUNX1 KRAS JAK2 FLT3 ETV6
36 leukemia, chronic myeloid 31.6 TP53 RUNX1 KRAS KIT JAK2 GATA2
37 acute promyelocytic leukemia 31.6 TP53 TERT RUNX1 NPM1 KRAS FLT3
38 sm-ahnmd 31.5 KIT JAK2 CHIC2
39 plasma cell neoplasm 31.5 TP53 KRAS IDH2 FLT3 DNMT3A
40 dyskeratosis congenita 31.5 TP53 TERT NPM1 GATA2
41 polycythemia vera 31.5 TP53 KIT JAK2 IDH2 ETV6 DNMT3A
42 lymphoma, non-hodgkin, familial 31.5 TP53 NPM1 JAK2 FLT3 ETV6
43 aggressive systemic mastocytosis 31.4 RUNX1 KIT FLT3
44 essential thrombocythemia 31.4 TP53 TERT KRAS KIT JAK2 IDH2
45 precursor t-cell acute lymphoblastic leukemia 31.4 PICALM NUP214 MLLT10 FLT3 ETV6
46 childhood acute lymphocytic leukemia 31.4 RUNX1 KRAS FLT3 ETV6
47 hemangioma 31.4 TP53 KRAS KIT IDH2
48 fibrosarcoma 31.4 TP53 KIT JAK2 ETV6
49 aplastic anemia 31.3 TP53 TERT RUNX1 GATA2 FLT3
50 chronic eosinophilic leukemia 31.3 KIT JAK2 FLT3 ETV6 CHIC2

Graphical network of the top 20 diseases related to Leukemia, Acute Myeloid:



Diseases related to Leukemia, Acute Myeloid

Symptoms & Phenotypes for Leukemia, Acute Myeloid

Human phenotypes related to Leukemia, Acute Myeloid:

31
# Description HPO Frequency HPO Source Accession
1 acute myeloid leukemia 31 HP:0004808

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Hematology:
acute myelogenous leukemia (aml)

Clinical features from OMIM®:

601626 (Updated 20-May-2021)

UMLS symptoms related to Leukemia, Acute Myeloid:


angina pectoris; chest pain; edema

GenomeRNAi Phenotypes related to Leukemia, Acute Myeloid according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.1 KRAS
2 Decreased viability GR00055-A-2 10.1 KRAS
3 Decreased viability GR00055-A-3 10.1 KRAS
4 Decreased viability GR00106-A-0 10.1 KRAS
5 Decreased viability GR00173-A 10.1 FLT3
6 Decreased viability GR00221-A-1 10.1 FLT3 KIT KRAS
7 Decreased viability GR00221-A-2 10.1 JAK2 KRAS
8 Decreased viability GR00221-A-4 10.1 FLT3
9 Decreased viability GR00240-S-1 10.1 PICALM TP53
10 Decreased viability GR00249-S 10.1 RUNX1 TERT TP53
11 Decreased viability GR00301-A 10.1 KIT KRAS
12 Decreased viability GR00381-A-1 10.1 KRAS
13 Decreased viability GR00386-A-1 10.1 CEBPA CHIC2 GATA2 LPP TERT TGM6
14 Decreased viability GR00402-S-2 10.1 DNMT3A RUNX1 TP53
15 Reduced mammosphere formation GR00396-S 9.17 CEBPA DNMT3A ETV6 IDH2 KRAS NUP214

MGI Mouse Phenotypes related to Leukemia, Acute Myeloid:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.46 CEBPA DNMT3A ETV6 FLT3 GATA2 JAK2
2 growth/size/body region MP:0005378 10.43 CEBPA CHIC2 DNMT3A ETV6 FLT3 GATA2
3 hematopoietic system MP:0005397 10.36 CEBPA CHIC2 DNMT3A ETV6 FLT3 GATA2
4 mortality/aging MP:0010768 10.36 CEBPA CHIC2 DNMT3A ETV6 FLT3 GATA2
5 cardiovascular system MP:0005385 10.35 CEBPA CHIC2 ETV6 GATA2 IDH2 JAK2
6 homeostasis/metabolism MP:0005376 10.34 CEBPA DNMT3A ETV6 FLT3 GATA2 JAK2
7 embryo MP:0005380 10.33 DNMT3A ETV6 GATA2 JAK2 KIT KRAS
8 endocrine/exocrine gland MP:0005379 10.31 CEBPA CHIC2 DNMT3A ETV6 FLT3 GATA2
9 immune system MP:0005387 10.29 CEBPA CHIC2 ETV6 FLT3 JAK2 KIT
10 liver/biliary system MP:0005370 10.17 CEBPA ETV6 GATA2 JAK2 KIT KRAS
11 integument MP:0010771 10.16 CEBPA CHIC2 ETV6 JAK2 KIT KRAS
12 neoplasm MP:0002006 10.11 CEBPA ETV6 FLT3 IDH2 JAK2 KIT
13 normal MP:0002873 9.96 CEBPA ETV6 GATA2 JAK2 KIT KRAS
14 no phenotypic analysis MP:0003012 9.87 CEBPA ETV6 FLT3 KIT KRAS RUNX1
15 reproductive system MP:0005389 9.85 CEBPA CHIC2 DNMT3A GATA2 JAK2 KIT
16 respiratory system MP:0005388 9.56 CEBPA JAK2 KIT KRAS RUNX1 SH3GL1
17 skeleton MP:0005390 9.32 DNMT3A FLT3 IDH2 JAK2 KIT KRAS

Drugs & Therapeutics for Leukemia, Acute Myeloid

Drugs for Leukemia, Acute Myeloid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 566)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotine Approved Phase 4 54-11-5 942 89594
2
Daunorubicin Approved Phase 4 20830-81-3 30323
3
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
4
Amsacrine Approved, Investigational Phase 4 51264-14-3 2179
5
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
6
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
7
Lenalidomide Approved Phase 4 191732-72-6 216326
8 interferons Phase 4
9 Interferon-alpha Phase 4
10 Antiparasitic Agents Phase 4
11 Antiprotozoal Agents Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Gemtuzumab Phase 4
14 Angiogenesis Inhibitors Phase 4
15
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
16
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
17
Vindesine Approved, Investigational Phase 3 53643-48-4, 59917-39-4 40839
18
Lorazepam Approved Phase 3 846-49-1 3958
19
Ofloxacin Approved Phase 3 82419-36-1 4583
20
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
21
Aldesleukin Approved Phase 3 110942-02-4, 85898-30-2
22
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 468682 2826718
23
Dalteparin Approved Phase 3 9005-49-6
24
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
25
Pentostatin Approved, Investigational Phase 3 53910-25-1 40926 439693
26
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
27
Carvedilol Approved, Investigational Phase 3 72956-09-3 2585
28
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
29
Enalaprilat Approved Phase 3 76420-72-9 6917719
30
Lactitol Approved, Investigational Phase 3 585-86-4 157355
31
Darbepoetin alfa Approved, Investigational Phase 3 209810-58-2, 11096-26-7
32
Palivizumab Approved, Investigational Phase 3 188039-54-5
33
Acyclovir Approved Phase 3 59277-89-3 2022
34
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
35
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
36
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
37
Morphine Approved, Investigational Phase 3 57-27-2 5288826
38
Lenograstim Approved, Investigational Phase 3 135968-09-1
39
Decitabine Approved, Investigational Phase 2, Phase 3 2353-33-5 451668
40
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414
41
Sargramostim Approved, Investigational Phase 3 123774-72-1, 83869-56-1
42
Cladribine Approved, Investigational Phase 3 4291-63-8 20279
43
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
44
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
45
Treosulfan Approved, Investigational Phase 3 299-75-2 9296
46
Ivosidenib Approved, Investigational Phase 3 1448347-49-6 71657455
47
Pegaspargase Approved, Investigational Phase 3 130167-69-0
48
Mercaptopurine Approved Phase 3 50-44-2 667490
49
Captopril Approved Phase 3 62571-86-2 44093
50
Lomustine Approved, Investigational Phase 2, Phase 3 13010-47-4 3950

Interventional clinical trials:

(show top 50) (show all 2534)
# Name Status NCT ID Phase Drugs
1 Multicenter Randomised Clinical Trial in Acute Myeloid Leukemia Treatment Based on Three Anthracyclines, Comparing Two Types of Consolidation With Different ARA-C Doses Followed by One Year Maintenance Unknown status NCT01587430 Phase 4 high dose ARA-C;standard dose ARA-C
2 Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia Before Allogeneic Hematopoietic Cell Transplantation Unknown status NCT01806116 Phase 4 decitabine
3 A Phase IV, Randomized Study to Evaluate the Safety and Efficacy of Idarubicin at Different Dosages Combined With Cytarabine as Induction Therapy for Newly Diagnosed Acute Myeloid Leukaemia Unknown status NCT02277847 Phase 4 Idarubicin(8mg/m2) and cytosine arabinoside;Idarubicin(10mg/m2), cytosine arabinoside
4 Treatment of Elderly Patients (>60 Years) With Acute Myeloblastic Leukemia or Advanced MDS (RAEB-T): An Open Randomized Study to Test the Efficacy of G-CSF-Priming and a Feasibility Trial of Dose-Reduced Allogeneic Transplantation and of Autologous Stem Cell Transplantation Unknown status NCT00199147 Phase 4 Cytarabine;Etoposide;Idarubicin;G-CSF;Fludarabine
5 A Randomized Comparison of Fludarabine in Combination With Cytarabine Versus High -Dose Cytarabine in Post-remission Therapy for AML1-ETO Acute Myeloid Leukemia Unknown status NCT02024308 Phase 4 Fludarabine;Cytarabine
6 Fludarabine and Cytarabine Versus High-dose Cytarabine in Consolidation Treatment of Core-bing Factor Acute Myeloid Leukemia: A Prospective, Multicenter, Randomized Study Unknown status NCT02926586 Phase 4 Fludarabine;Cytarabine
7 Early Tapering of Immunosuppressive Agents After Allogeneic Hematopoietic Stem Cell Transplantation Can Improve the Survival of Patients With Advanced Acute Myeloid Leukemia. Unknown status NCT03150134 Phase 4 Cyclosporine;routine reduction of immunosuppressive drugs(cyclosporine)
8 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor: a Prospective, Multicentre, Randomised Controlled Trial Unknown status NCT02933333 Phase 4
9 Interferon for the Intervention of Molecular Relapse in t (8; 21) AML After Allo-HSCT Unknown status NCT02027064 Phase 4 Interferon-alpha
10 AML96 - Risk-Adapted and Randomized Postremission-Therapy for Adult Acute Myeloid Leukemia Patients. A Cooperative AML-Study of the German SHG-Study Group. Completed NCT00180115 Phase 4 Cytarabine Dosage
11 AML2003 - Randomized Comparison Between Standard-Therapy and Intensified Therapy for Adult Acute Myeloid Leukemia Patients <= 60 Years. A Prospective, Randomized, Multi-center Therapy-Optimizing-Study. Completed NCT00180102 Phase 4 Cytarabine vs. Cytarabine+Amsacrine+Mitoxantrone
12 PETHEMA LAM07: Prospective, Multicenter, Uncontrolled Cohort Study to Analyze the Efficacy of a Risk Adapted Treatment Strategy, Including Gemtuzumab Ozogamicin (GO) During Consolidation, for Patients With Acute Myeloid Leukemia (AML) Completed NCT01041040 Phase 4 gemtuzumab
13 A Phase IV Study of Corticosteroids As Prophylaxis for Infusion-Related Adverse Events to Mylotarg® in Patients With Acute Myelogenous Leukemia (AML) Completed NCT00304447 Phase 4 Mylotarg
14 PETHEMA-LAM99:Treatment of the Acute Myeloblastic Leukaemia in Patients Over 65 Years Completed NCT00464217 Phase 4 ARA-C;Idarubicin;Leucomax
15 FLAG-IDA Chemotherapy Induction Follow by Intensive Chemotherapy Postremission +/- Autologous Hemopoietic Stem Cell Transplantation or Bone Marrow Transplantation in Patients With High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia. Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
16 A Randomized Open-Label Trial of Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
17 FLAT: Fludarabine, Cytarabine and Topotecan in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia Completed NCT00488709 Phase 4 Topotecan;Fludarabine;Cytarabine
18 Open-Label, Multicenter, Effects of Remission Maintenance Therapy With Ceplene® , Given in Conjunction With Low-Dose Interleukin-2, on Immune Response and Minimal Residual Disease in Adult Patients With AML in First Complete Remission Completed NCT01347996 Phase 4 histamine dihydrochloride and IL-2
19 Incidence of Respiratory Viral Infections During AML Induction and Consolidation Chemotherapy Completed NCT01819792 Phase 4
20 A Clinical Trial to Evaluate the Efficacy and Safety of Recombinant Human Thrombopoietin in the Treatment of Thrombocytopenia After Chemotherapy in Acute Myeloid Leukemia Completed NCT02267993 Phase 4 recombinant human thrombopoietin
21 Incidence of Invasive Fungal Disease in Patients Receiving Immunosuppressive Therapy, Intensive Chemotherapy or Reduced Intensity Haematopoietic Stem Cell Transplantation on Posaconazole Prophylaxis Completed NCT02875743 Phase 4 Posaconazole
22 A Phase 4 Study of the Pharmacokinetics of Oral Posaconazole (SCH 56592) Among Patients With Compromised Gastrointestinal Function and at High Risk for Invasive Fungal Infection Completed NCT00686543 Phase 4 Posaconazole
23 Therapy of AML in Patients Older Than 60 Years: Randomized Comparison of a Double Induction With Daunorubicin and AraC (as Continuous Infusion) With a Double Induction With Mitoxantrone and Intermittent, Medium High Dose AraC Completed NCT00180167 Phase 4 randomization between two established Chemotherapies
24 The Feasibility of Safely Managing Patients Receiving Induction With Liposomal Daunorubicin and Cytarabine (CPX-351) for Acute Myeloid Leukemia (AML) in an Outpatient Environment Recruiting NCT03988205 Phase 4 CPX-351
25 The Efficacy and Safety of Azacytidine Combined With HAG Regimen Versus Azacytidine for Elderly Patients With Newly Diagnosed Myeloid Malignancy: a Prospective, Randomized Controlled Trial Recruiting NCT03873311 Phase 4 Azacytidine, HAG Regimen;Azacytidine
26 Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy Recruiting NCT04484532 Phase 4
27 A SINGLE ARM, OPEN-LABEL, PHASE 4 STUDY EVALUATING QT INTERVAL, PHARMACOKINETICS, AND SAFETY OF GEMTUZUMAB OZOGAMICIN (MYLOTARG (TRADEMARKER)) AS A SINGLE-AGENT REGIMEN IN PATIENTS WITH RELAPSED OR REFRACTORY CD33-POSITIVE ACUTE MYELOID LEUKEMIA Recruiting NCT03727750 Phase 4 Gemtuzumab Ozogamicin
28 Study 200170: A Rollover Study to Provide Continued Treatment With Eltrombopag Active, not recruiting NCT01957176 Phase 4 ELT
29 A Prospective, Randomized, Controlled Trial of Decitabine Versus Conventional Chemotherapy for Maintenance Therapy of Patients With Acute Myeloid Leukemia With t(8;21) Active, not recruiting NCT03026842 Phase 4 Decitabine;Daunorubicin, Cytarabine;Mitoxantrone, Cytarabine;Aclacinomycin, Cytarabine
30 PILOT STUDY PHASE II, Multicenter, Non-randomized, TO ASSESS THE EFFICACY AND SAFETY OF LENALIDOMIDE IN INDUCTION AND POST-INDUCTION IN PATIENTS WITH NOVO Acute Myeloid Leukemia (AML) WITH Cytogenetic Abnormality Monosomy 5 Terminated NCT01198054 Phase 4 Lenalidomide
31 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
32 Multicenter, Double-Blind, Randomized Study to Compare the Safety and Efficacy of Levofloxacin With That of Cefepime in the Treatment of Fever and Neutropenia - Phase IIIB Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
33 Randomised Comparison of OSHO Induction vs. the German AML Intergroup Standard, Randomised Comparison of AraC/Mtx vs. Flu/AraC/Mtx in Pts Without CR After One Induction Cycle and Randomized Comparison of One vs. Two Consolidation Therapies. Unknown status NCT01414231 Phase 3 Cytarabine
34 Recombinant Human Thrombopoietin (rhTPO) in Management of Chemotherapy-induced Thrombocytopenia in Acute Myelocytic Leukemia: a Multicenter Clinical Trial Unknown status NCT02244658 Phase 3 rhTPO
35 Randomised Prospective Comparison of the nonmyélo-Ablative Allograft and the Traditional Allograft in Acute Myeloid Leukaemia in Complete Remission of the Adult Unknown status NCT00224614 Phase 3
36 ACUTE MYELOID LEUKAEMIA TRIAL 12 Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
37 A Randomised Study Comparing an Oral Regimen (Idarubicin and Etoposide) With an Intravenous Regimen (MAE) for Consolidation in Patients Over 55 Years With Acute Myeloid Leukaemia in First Complete Remission Unknown status NCT00003602 Phase 3 cytarabine;etoposide;idarubicin;mitoxantrone hydrochloride
38 Phase III, Randomized, Multicenter Study to Assess the Efficacy and Safety of HuM195 (Recombinant Humanized Anti-CD33 Monoclonal Antibody) in Combination With Standardized Chemotherapy Compared to Standardized Chemotherapy Alone in the Treatment of Patients With Refractory or First-Relapsed Acute Myelogenous Leukemia (AML) Unknown status NCT00006045 Phase 3 cytarabine;etoposide;mitoxantrone hydrochloride
39 Autologous Peripheral Blood Stem Cell Transplantation (PSCT) Versus a Second Intensive Consolidation Course After a Common Induction and Consolidation Course in Patients With Bad Prognosis Myelodysplastic Syndromes (MDS) and Acute Myelogenous Leukemia Secondary (SAML) to MDS of More Acute Than 6 Months Duration Unknown status NCT00002926 Phase 3 cytarabine;etoposide;idarubicin
40 RANDOMIZED PHASE III STUDY OF INDUCTION (ICE VS MICE VS DCE) AND INTENSIVE CONSOLIDATION (IDIA VS NOVIA VS DIA) FOLLOWED BY BONE MARROW TRANSPLANTATION IN ACUTE MYELOGENOUS LEUKEMIA: AML 10 PROTOCOL Unknown status NCT00002549 Phase 3 busulfan;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mesna;mitoxantrone hydrochloride
41 The Clinical Research About the Therapeutic Effect and Safety of 10 Days Regimen With Single-agent of Decitabine for Elderly AML Patients Unknown status NCT01633099 Phase 3 Decitabine
42 A PALG Prospective Multicenter Clinical Trial to Compare the Efficacy of Two Standard Induction Therapies (DA-90 vs DAC) and Two Standard Salvage Regimens (FLAG-IDA vs CLAG-M) in AML Patients ≤ 60 Years Old Unknown status NCT03257241 Phase 3 A arm (DA-90);B arm (DAC);A arm (CLAG-M);B arm (FLAG-IDA)
43 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
44 A Phase 3, Randomized, Double-Blind, Multicenter Study of Proteinase 3 PR1 Peptide Mixed With Montanide ISA-51 VG Adjuvant and Administered With GM-CSF in Elderly Patients With AML in First Complete Remission or Adults in Second Complete Remission: A Pivotal Study Unknown status NCT00454168 Phase 3
45 Gemtuzumab Ozogamicin (GO) Monotherapy Versus Standard Supportive Care for Previously Untreated AML in Elderly Patients Who Are Not Eligible for Intensive Chemotherapy: A Randomized Phase II/III Trial (AML-19) of the EORTC-LG and GIMEMA-ALWP Unknown status NCT00091234 Phase 2, Phase 3 gemtuzumab ozogamicin
46 Phase III Open-Label Randomized Study of Amonafide L-Malate in Combination With Cytarabine Compared to Daunorubicin in Combination With Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- The ACCEDE Study Unknown status NCT00715637 Phase 3 Daunorubicin and Cytarabine;Amonafide and Cytarabine
47 Protocol for the Treatment of Adults Aged </= 60 Years With De Novo Acute Myeloblastic Leukaemia or Secondary AML or RAEB-T (AML 01/99 Trial) Unknown status NCT00209833 Phase 2, Phase 3 Cytarabine;Idarubicin;Etoposide;Fludarabine;G-CSF;Daunorubicine
48 Decitabine Augments for Post Allogeneic Stem Cell Transplantation in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndrome Unknown status NCT01809392 Phase 2, Phase 3 decitabine
49 A Prospective Randomized Comparison of Idarubicin and High-dose Daunorubicin in Combination With Cytarabine in the Induction Chemotherapy for Acute Myeloid Leukemia Unknown status NCT01145846 Phase 3 Cytarabine plus Daunorubicin [Arm II (AD regimen)]
50 Randomised Trial on Allogeneic Haematopoietic Stem Cell Transplantation in Patients Under the Age of 60 Years With Acute Myeloid Leukemia of Intermediate Risk in First Complete Remission and a Matched Sibling or Unrelated Donor (ETAL-1) Unknown status NCT01246752 Phase 3 Consolidation chemotherapy, i.e. High-dose Cytarabine (HiDAC)

Search NIH Clinical Center for Leukemia, Acute Myeloid

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Cyclophosphamide
Etoposide
etoposide phosphate
Idarubicin
Idarubicin Hydrochloride
Mitoxantrone
Mitoxantrone Hydrochloride

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Acute Myeloid cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: leukemia, myeloid, acute

Genetic Tests for Leukemia, Acute Myeloid

Genetic tests related to Leukemia, Acute Myeloid:

# Genetic test Affiliating Genes
1 Acute Myeloid Leukemia 29 CBFB CEBPA CHIC2 DNMT3A ETV6 FLT3 GATA2 JAK2 KIT KRAS LPP MLLT10 NPM1 NUP214 PICALM RUNX1 SH3GL1 TERT
2 Leukemia, Acute Myeloid, Susceptibility to 29

Anatomical Context for Leukemia, Acute Myeloid

MalaCards organs/tissues related to Leukemia, Acute Myeloid:

40
Myeloid, Bone Marrow, Bone, T Cells, Breast, Nk Cells, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Leukemia, Acute Myeloid:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Common Myeloid Progenitor Cells Affected by disease
2 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate

Publications for Leukemia, Acute Myeloid

Articles related to Leukemia, Acute Myeloid:

(show top 50) (show all 30124)
# Title Authors PMID Year
1
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. 61 6 57
23634996 2013
2
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. 61 6 57
21892162 2011
3
Recurring mutations found by sequencing an acute myeloid leukemia genome. 61 57 6
19657110 2009
4
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. 6 57 61
19147845 2009
5
Somatic heterozygous mutations in ETV6 (TEL) and frequent absence of ETV6 protein in acute myeloid leukemia. 61 6 57
15806161 2005
6
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. 6 57 54
15659725 2005
7
Mutation of CEBPA in familial acute myeloid leukemia. 57 6 61
15575056 2004
8
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 57 6
22504184 2012
9
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. 47 61 57
18308931 2008
10
The JAK2 V617F mutation in de novo acute myelogenous leukemias. 57 6
16247455 2006
11
Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. 6 57
8955068 1996
12
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder. 61 54 6
19357396 2009
13
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. 61 6
32098966 2020
14
Gilteritinib or Chemotherapy for Relapsed or Refractory FLT3-Mutated AML. 61 57
31665578 2019
15
The spectrum of DNMT3A variants in Tatton-Brown-Rahman syndrome overlaps with that in hematologic malignancies. 61 6
28941052 2017
16
Index case of acute myeloid leukemia in a family harboring a novel CEBPA germ line mutation. 61 6
29296967 2017
17
Acute myeloid leukemia-associated DNMT3A p.Arg882His mutation in a patient with Tatton-Brown-Rahman overgrowth syndrome as a constitutional mutation. 61 6
27991732 2017
18
Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia. 61 6
27133828 2016
19
Whole exome sequencing reveals a C-terminal germline variant in CEBPA-associated acute myeloid leukemia: 45-year follow up of a large family. 61 6
26721895 2016
20
Two novel germline DDX41 mutations in a family with inherited myelodysplasia/acute myeloid leukemia. 61 6
26944477 2016
21
Assessment of Minimal Residual Disease in Standard-Risk AML. 61 57
26789727 2016
22
Disease evolution and outcomes in familial AML with germline CEBPA mutations. 6 61
26162409 2015
23
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. 61 57
25678665 2015
24
Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients. 6 61
24487413 2014
25
WT1 overexpression affecting clinical outcome in non-hodgkin lymphomas and adult acute lymphoblastic leukemia. 61 6
24374862 2014
26
Minimal residual disease monitoring in t(8;21) acute myeloid leukemia based on RUNX1-RUNX1T1 fusion quantification on genomic DNA. 61 6
24616160 2014
27
Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 61 6
24619500 2014
28
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. 6 61
24656771 2014
29
WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy. 61 6
24521058 2014
30
RUNX1 mutation associated with clonal evolution in relapsed pediatric acute myeloid leukemia with t(16;21)(p11;q22). 6 61
24374719 2014
31
Clinical impact of gene mutations and lesions detected by SNP-array karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: results of the ALFA-0701 trial. 61 6
24659740 2014
32
Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. 6 61
24381225 2014
33
Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients. 61 6
24606448 2014
34
Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review. 61 6
24641375 2014
35
Overexpression of Wilms tumor 1 gene as a negative prognostic indicator in acute myeloid leukemia. 6 61
24667279 2014
36
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera. 61 6
24404189 2014
37
Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. 61 6
24046014 2013
38
Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia. 61 6
23949315 2013
39
Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22). 61 6
24045550 2013
40
The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia. 6 61
23783394 2013
41
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia. 6 61
23878140 2013
42
[Mutation of isocitrate dehydrogenase 2 (IDH2) gene in Chinese AML patients and its clinical significance]. 6 61
23815907 2013
43
SF3B1 mutation is a rare event in Chinese patients with acute and chronic myeloid leukemia. 61 6
23395771 2013
44
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 6 61
23430109 2013
45
Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. 6 61
23321257 2013
46
Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 61 6
23261068 2013
47
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. 61 6
23714533 2013
48
Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG). 6 61
23115274 2013
49
Potential application of IDH1 and IDH2 mutations as prognostic indicators in non-promyelocytic acute myeloid leukemia: a meta-analysis. 6 61
22616558 2012
50
HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1. 61 57
22931314 2012

Variations for Leukemia, Acute Myeloid

ClinVar genetic disease variations for Leukemia, Acute Myeloid:

6 (show top 50) (show all 672)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FLT3 FLT3, INTERNAL TANDEM DUP Duplication Pathogenic 16270 GRCh37:
GRCh38:
2 KIT NM_000222.2(KIT):c.2446G>T (p.Asp816Tyr) SNV Pathogenic 13860 rs121913506 GRCh37: 4:55599320-55599320
GRCh38: 4:54733154-54733154
3 NPM1 NM_002520.6(NPM1):c.860_863dupTCTG Duplication Pathogenic 13998 rs587776806 GRCh37: 5:170837543-170837544
GRCh38: 5:171410539-171410540
4 NPM1 NM_002520.6(NPM1):c.863_864insCATG (p.Trp288fs) Insertion Pathogenic 13999 rs1554138188 GRCh37: 5:170837545-170837546
GRCh38: 5:171410541-171410542
5 NPM1 NM_002520.6(NPM1):c.863_864insCGTG (p.Trp288fs) Insertion Pathogenic 14000 rs1554138188 GRCh37: 5:170837545-170837546
GRCh38: 5:171410541-171410542
6 NPM1 NM_002520.6(NPM1):c.863_864insCCTG (p.Trp288fs) Insertion Pathogenic 14001 rs1554138189 GRCh37: 5:170837544-170837545
GRCh38: 5:171410540-171410541
7 JAK2 , INSL6 NM_004972.3(JAK2):c.1821G>C (p.Lys607Asn) SNV Pathogenic 14663 rs121912472 GRCh37: 9:5073742-5073742
GRCh38: 9:5073742-5073742
8 FLT3 NM_004119.3(FLT3):c.2520_2521insGGATCC (p.Asn841_Tyr842insGlySer) Insertion Pathogenic 16271 rs398122514 GRCh37: 13:28592624-28592625
GRCh38: 13:28018487-28018488
9 FLT3 NM_004119.3(FLT3):c.2504A>T (p.Asp835Val) SNV Pathogenic 16272 rs121909646 GRCh37: 13:28592641-28592641
GRCh38: 13:28018504-28018504
10 FLT3 NM_004119.3(FLT3):c.2503G>C (p.Asp835His) SNV Pathogenic 16273 rs121913488 GRCh37: 13:28592642-28592642
GRCh38: 13:28018505-28018505
11 FLT3 NM_004119.3(FLT3):c.2503G>A (p.Asp835Asn) SNV Pathogenic 16274 rs121913488 GRCh37: 13:28592642-28592642
GRCh38: 13:28018505-28018505
12 CEBPA NM_001285829.1(CEBPA):c.-243_-237del Deletion Pathogenic 17566 rs587776848 GRCh37: 19:33793200-33793206
GRCh38: 19:33302294-33302300
13 CEBPA NM_001285829.1(CEBPA):c.-210G>T SNV Pathogenic 17567 rs121912791 GRCh37: 19:33793173-33793173
GRCh38: 19:33302267-33302267
14 CEBPA NM_001285829.1(CEBPA):c.-107A>T SNV Pathogenic 17568 rs28931590 GRCh37: 19:33793070-33793070
GRCh38: 19:33302164-33302164
15 CEBPA NM_004364.4(CEBPA):c.935_991dup (p.Gln312_Gln330dup) Duplication Pathogenic 17569 rs1555741948 GRCh37: 19:33792329-33792330
GRCh38: 19:33301423-33301424
16 CEBPA NM_004364.4(CEBPA):c.925_951dup (p.Glu309_Leu317dup) Duplication Pathogenic 17570 rs1555741967 GRCh37: 19:33792369-33792370
GRCh38: 19:33301463-33301464
17 CEBPA NM_001285829.1(CEBPA):c.-147_-144dup Duplication Pathogenic 17571 rs587776849 GRCh37: 19:33793106-33793107
GRCh38: 19:33302200-33302201
18 CEBPA NM_001285829.1(CEBPA):c.-290del Deletion Pathogenic 17572 rs137852728 GRCh37: 19:33793253-33793253
GRCh38: 19:33302347-33302347
19 CEBPA NM_001285829.1(CEBPA):c.-217del Deletion Pathogenic 21396 rs137852730 GRCh37: 19:33793180-33793180
GRCh38: 19:33302274-33302274
20 CEBPA NM_004364.4(CEBPA):c.217_218insC (p.Phe73fs) Insertion Pathogenic 21398 rs137852733 GRCh37: 19:33793103-33793104
GRCh38: 19:33302197-33302198
21 CEBPA NM_004364.4(CEBPA):c.318_319dupTG (p.Asp107Valfs*54) Duplication Pathogenic 21399 rs137852732 GRCh37: 19:33793001-33793002
GRCh38: 19:33302095-33302096
22 DDX41 NM_016222.4(DDX41):c.415_418dup (p.Asp140delinsGlyTer) Duplication Pathogenic 210843 rs762890562 GRCh37: 5:176942945-176942946
GRCh38: 5:177515944-177515945
23 IDH2 NM_001289910.1(IDH2):c.263G>A (p.Arg88Gln) SNV Pathogenic 14716 rs121913502 GRCh37: 15:90631934-90631934
GRCh38: 15:90088702-90088702
24 IDH2 NM_001289910.1(IDH2):c.360G>C (p.Arg120Ser) SNV Pathogenic 375985 rs1057519736 GRCh37: 15:90631837-90631837
GRCh38: 15:90088605-90088605
25 FLT3 NM_004119.3(FLT3):c.2508C>G (p.Ile836Met) SNV Pathogenic 375969 rs121913232 GRCh37: 13:28592637-28592637
GRCh38: 13:28018500-28018500
26 IDH2 NM_001289910.1(IDH2):c.359G>A (p.Arg120Lys) SNV Pathogenic 375987 rs121913503 GRCh37: 15:90631838-90631838
GRCh38: 15:90088606-90088606
27 IDH1 NM_001282386.1(IDH1):c.395G>T (p.Arg132Leu) SNV Pathogenic 375889 rs121913500 GRCh37: 2:209113112-209113112
GRCh38: 2:208248388-208248388
28 IDH2 NM_001289910.1(IDH2):c.262C>T (p.Arg88Trp) SNV Pathogenic 375989 rs267606870 GRCh37: 15:90631935-90631935
GRCh38: 15:90088703-90088703
29 FLT3 NM_004119.3(FLT3):c.2505T>A (p.Asp835Glu) SNV Pathogenic 375972 rs121913487 GRCh37: 13:28592640-28592640
GRCh38: 13:28018503-28018503
30 IDH2 NM_001289910.1(IDH2):c.263G>T (p.Arg88Leu) SNV Pathogenic 375988 rs121913502 GRCh37: 15:90631934-90631934
GRCh38: 15:90088702-90088702
31 TGM6 NM_198994.3(TGM6):c.1550T>G (p.Leu517Trp) SNV Pathogenic 31085 rs387907097 GRCh37: 20:2398091-2398091
GRCh38: 20:2417445-2417445
32 ETV6 NM_001987.4(ETV6):c.1307_1308insGGG (p.His436delinsGlnGly) Insertion Pathogenic 8985 rs587776710 GRCh37: 12:12043928-12043929
GRCh38: 12:11890994-11890995
33 ETV6 NM_001987.4(ETV6):c.226G>T (p.Glu76Ter) SNV Pathogenic 8984 rs121434637 GRCh37: 12:11992136-11992136
GRCh38: 12:11839202-11839202
34 DNMT3A NM_022552.5(DNMT3A):c.2644C>G (p.Arg882Gly) SNV Pathogenic 375883 rs377577594 GRCh37: 2:25457243-25457243
GRCh38: 2:25234374-25234374
35 IDH1 NM_001282386.1(IDH1):c.395G>A (p.Arg132His) SNV Pathogenic 156444 rs121913500 GRCh37: 2:209113112-209113112
GRCh38: 2:208248388-208248388
36 DNMT3A NM_022552.5(DNMT3A):c.2645G>A (p.Arg882His) SNV Pathogenic 375881 rs147001633 GRCh37: 2:25457242-25457242
GRCh38: 2:25234373-25234373
37 IDH2 NM_001289910.1(IDH2):c.359G>T (p.Arg120Met) SNV Pathogenic 375986 rs121913503 GRCh37: 15:90631838-90631838
GRCh38: 15:90088606-90088606
38 FLT3 NM_004119.3(FLT3):c.2506A>C (p.Ile836Leu) SNV Pathogenic 375970 rs1057519726 GRCh37: 13:28592639-28592639
GRCh38: 13:28018502-28018502
39 IDH1 NM_001282386.1(IDH1):c.394C>G (p.Arg132Gly) SNV Pathogenic 375892 rs121913499 GRCh37: 2:209113113-209113113
GRCh38: 2:208248389-208248389
40 DNMT3A NM_022552.5(DNMT3A):c.2645G>C (p.Arg882Pro) SNV Pathogenic 375880 rs147001633 GRCh37: 2:25457242-25457242
GRCh38: 2:25234373-25234373
41 IDH1 NM_001282386.1(IDH1):c.395G>C (p.Arg132Pro) SNV Pathogenic 375890 rs121913500 GRCh37: 2:209113112-209113112
GRCh38: 2:208248388-208248388
42 DNMT3A NM_022552.5(DNMT3A):c.2644C>A (p.Arg882Ser) SNV Pathogenic 375884 rs377577594 GRCh37: 2:25457243-25457243
GRCh38: 2:25234374-25234374
43 IDH1 NM_001282386.1(IDH1):c.394C>A (p.Arg132Ser) SNV Pathogenic 375893 rs121913499 GRCh37: 2:209113113-209113113
GRCh38: 2:208248389-208248389
44 FLT3 NM_004119.3(FLT3):c.2504A>C (p.Asp835Ala) SNV Pathogenic 375973 rs121909646 GRCh37: 13:28592641-28592641
GRCh38: 13:28018504-28018504
45 FLT3 NM_004119.3(FLT3):c.2505T>G (p.Asp835Glu) SNV Pathogenic 375971 rs121913487 GRCh37: 13:28592640-28592640
GRCh38: 13:28018503-28018503
46 KIT NM_000222.3(KIT):c.2447A>T SNV Pathogenic 13852 rs121913507 GRCh37: 4:55599321-55599321
GRCh38: 4:54733155-54733155
47 KIT NM_000222.2(KIT):c.2446_2447delinsAT (p.Asp816Ile) Indel Pathogenic 375926 rs1057519709 GRCh37: 4:55599320-55599321
GRCh38: 4:54733154-54733155
48 DNMT3A NM_022552.5(DNMT3A):c.2645G>T (p.Arg882Leu) SNV Pathogenic 375879 rs147001633 GRCh37: 2:25457242-25457242
GRCh38: 2:25234373-25234373
49 IDH1 NM_001282386.1(IDH1):c.394C>T (p.Arg132Cys) SNV Pathogenic 375891 rs121913499 GRCh37: 2:209113113-209113113
GRCh38: 2:208248389-208248389
50 DDX41 NM_016222.4(DDX41):c.712C>A (p.Pro238Thr) SNV Pathogenic 403734 rs376093707 GRCh37: 5:176942003-176942003
GRCh38: 5:177515002-177515002

UniProtKB/Swiss-Prot genetic disease variations for Leukemia, Acute Myeloid:

72
# Symbol AA change Variation ID SNP ID
1 CEBPA p.His84Leu VAR_072677 rs28931590
2 DNMT3A p.Arg882Cys VAR_067236 rs377577594
3 DNMT3A p.Arg882His VAR_067237 rs147001633
4 JAK2 p.Lys607Asn VAR_032696 rs121912472
5 JAK2 p.Val617Phe VAR_032697 rs77375493
6 SETBP1 p.Gly870Ser VAR_063809 rs267607040
7 SETBP1 p.Ser854Ala VAR_069848
8 SETBP1 p.Gly870Arg VAR_069854
9 SETBP1 p.Ile871Ser VAR_069856 rs267607038

Copy number variations for Leukemia, Acute Myeloid from CNVD:

7 (show top 50) (show all 491)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 13336 1 1 124300000 Insertion Acute myeloid leukemia
2 13759 1 1 28000000 Deletion Acute myeloid leukemia
3 14790 1 110122000 110569000 Gain or loss Acute myeloid leukemia
4 17466 1 142902432 245422360 Duplication Acute myeloid leukemia
5 18096 1 143961000 247125000 Gain or loss Acute myeloid leukemia
6 26098 1 197094625 197094734 Amplification Acute myeloid leukemia
7 26100 1 197094796 197094905 Amplification Acute myeloid leukemia
8 35769 1 67074000 69951000 Gain or loss Acute myeloid leukemia
9 36085 1 71305902 71305987 Amplification MIR186 Acute myeloid leukemia
10 38187 10 1 6700000 Insertion IL15RA Acute myeloid leukemia
11 38188 10 1 6700000 Insertion PRKCQ Acute myeloid leukemia
12 41990 10 27075530 27189965 Translate ABI1 Acute myeloid leukemia
13 52810 11 2016406 2019065 Methylation H19 Acute myeloid leukemia
14 53744 11 32409321 32457081 Mutation WT1 Acute myeloid leukemia
15 54217 11 39671000 39746000 Loss Acute myeloid leukemia
16 54954 11 48161000 49658000 Gain Acute myeloid leukemia
17 55252 11 50257000 134448000 Gain Acute myeloid leukemia
18 55325 11 51052000 134450000 Gain Acute myeloid leukemia
19 55425 11 52900000 134452384 Deletion Acute myeloid leukemia
20 60678 11 89295514 104865304 Triplication Acute myeloid leukemia
21 61530 12 1 35400000 Deletion Acute myeloid leukemia
22 69937 12 56502838 96440466 Deletion Acute myeloid leukemia
23 69940 12 56504659 56504742 Deletion Acute myeloid leukemia
24 73728 12 96000 1461000 Gain Acute myeloid leukemia
25 75137 13 16000000 114142980 Deletion Acute myeloid leukemia
26 75165 13 17900000 115169878 Copycopy numbernumber neutral LOH Acute myeloid leukemia
27 75258 13 18400000 31100000 Insertion CDX2 Acute myeloid leukemia
28 75259 13 18400000 31100000 Insertion FLT3 Acute myeloid leukemia
29 75260 13 18400000 31100000 Insertion PAN3 Acute myeloid leukemia
30 76199 13 28577411 28674729 Mutation FLT3 Acute myeloid leukemia
31 80553 13 93890030 111773454 Deletion Acute myeloid leukemia
32 89057 14 99645745 99645843 Amplification Acute myeloid leukemia
33 90184 15 20318000 100211000 Gain Acute myeloid leukemia
34 90185 15 20318000 38892000 Gain Acute myeloid leukemia
35 94916 15 72016248 72105212 Gain LOXL1 Acute myeloid leukemia
36 94917 15 72016248 72105212 Gain PML Acute myeloid leukemia
37 94918 15 72016248 72105212 Gain STOML1 Acute myeloid leukemia
38 98134 16 15407000 16152000 Gain Acute myeloid leukemia
39 99468 16 26942000 28606000 Gain Acute myeloid leukemia
40 112824 17 41212860 60108628 Deletion Acute myeloid leukemia
41 119164 18 1 15400000 Deletion Acute myeloid leukemia
42 124099 19 1 28500000 Insertion Acute myeloid leukemia
43 134549 2 102700000 110200000 Deletion Acute myeloid leukemia
44 134662 2 10532565 24778632 Deletion Acute myeloid leukemia
45 135007 2 110200000 114400000 Deletion Acute myeloid leukemia
46 135195 2 112993000 124591000 Gain Acute myeloid leukemia
47 143561 2 238104652 242757057 Duplication Acute myeloid leukemia
48 144236 2 24319039 25368389 Deletion Acute myeloid leukemia
49 160293 22 11800000 49691432 Insertion BCR Acute myeloid leukemia
50 160294 22 11800000 49691432 Insertion CHEK2 Acute myeloid leukemia

Expression for Leukemia, Acute Myeloid

Search GEO for disease gene expression data for Leukemia, Acute Myeloid.

Pathways for Leukemia, Acute Myeloid

Pathways related to Leukemia, Acute Myeloid according to KEGG:

36
# Name Kegg Source Accession
1 Acute myeloid leukemia hsa05221
2 Transcriptional misregulation in cancer hsa05202

GO Terms for Leukemia, Acute Myeloid

Cellular components related to Leukemia, Acute Myeloid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 TP53 TERT RUNX1 PICALM NUP214 NPM1
2 cytosol GO:0005829 9.44 TP53 TERT SH3GL1 PICALM NUP214 NPM1

Biological processes related to Leukemia, Acute Myeloid according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10 TP53 RUNX1 GATA2 ETV6 DNMT3A CEBPA
2 viral process GO:0016032 9.97 TP53 NUP214 NPM1 FLT3 CEBPA
3 positive regulation of cell proliferation GO:0008284 9.95 NPM1 KRAS KIT JAK2 FLT3
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 TP53 RUNX1 NPM1 MLLT10 GATA2 ETV6
5 positive regulation of gene expression GO:0010628 9.91 TP53 KRAS KIT GATA2 CEBPA
6 MAPK cascade GO:0000165 9.86 KRAS KIT JAK2 FLT3
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 KIT JAK2 FLT3
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 KIT JAK2 FLT3
9 hematopoietic stem cell proliferation GO:0071425 9.57 RUNX1 ETV6
10 negative regulation of gene expression GO:0010629 9.55 TP53 TERT RUNX1 PICALM GATA2
11 positive regulation of MAP kinase activity GO:0043406 9.54 KRAS KIT FLT3
12 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.49 TP53 TERT
13 ribosomal small subunit export from nucleus GO:0000056 9.46 NUP214 NPM1
14 ribosomal large subunit export from nucleus GO:0000055 9.43 NUP214 NPM1
15 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.43 TP53 TERT GATA2
16 cytokine-mediated signaling pathway GO:0019221 9.43 TP53 KRAS KIT JAK2 FLT3 CEBPA
17 myeloid progenitor cell differentiation GO:0002318 9.32 KIT FLT3
18 hemopoiesis GO:0030097 9.02 RUNX1 PICALM KIT GATA2 FLT3

Molecular functions related to Leukemia, Acute Myeloid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.55 TP53 RUNX1 GATA2 ETV6 CEBPA
2 chromatin binding GO:0003682 9.43 TP53 NPM1 MLLT10 GATA2 DNMT3A CEBPA
3 transcription factor binding GO:0008134 9.1 TP53 RUNX1 NPM1 GATA2 DNMT3A CEBPA

Sources for Leukemia, Acute Myeloid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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