Leukemia, Acute, X-Linked disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Leukemia, Acute, X-Linked

MalaCards integrated aliases for Leukemia, Acute, X-Linked:

Name: Leukemia, Acute, X-Linked ⁵⁷ ²⁹ ⁶

Characteristics:

OMIM:

⁵⁷

Inheritance:
? x-linked form

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 308960

MedGen ⁴² C3501854

SNOMED-CT via HPO ⁶⁹ 24072005 91855006

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Summaries for Leukemia, Acute, X-Linked

MalaCards based summary : Leukemia, Acute, X-Linked An important gene associated with Leukemia, Acute, X-Linked is JAK1 (Janus Kinase 1). Related phenotype is acute leukemia.

Description from OMIM: 308960

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Related Diseases for Leukemia, Acute, X-Linked

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Symptoms & Phenotypes for Leukemia, Acute, X-Linked

Symptoms via clinical synopsis from OMIM:

⁵⁷

Heme:
acute leukemia
preleukemic blood disease

Clinical features from OMIM:

308960

Human phenotypes related to Leukemia, Acute, X-Linked:

³²

#	Description	HPO Frequency	HPO Source Accession
1	acute leukemia ³²		HP:0002488

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Drugs & Therapeutics for Leukemia, Acute, X-Linked

Search Clinical Trials , NIH Clinical Center for Leukemia, Acute, X-Linked

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Genetic Tests for Leukemia, Acute, X-Linked

Genetic tests related to Leukemia, Acute, X-Linked:

#	Genetic test	Affiliating Genes
1	Leukemia, Acute, ?x-Linked ²⁹

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Anatomical Context for Leukemia, Acute, X-Linked

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Publications for Leukemia, Acute, X-Linked

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Genes for Leukemia, Acute, X-Linked

Genes related to Leukemia, Acute, X-Linked (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	JAK1	Janus Kinase 1	Protein Coding	17.79	GeneCards inferred via : Variants (show sections)

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Variations for Leukemia, Acute, X-Linked

ClinVar genetic disease variations for Leukemia, Acute, X-Linked:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	JAK1	NM_002227.3(JAK1): c.1972G> T (p.Val658Phe)	single nucleotide variant	Likely pathogenic	rs1057519753	GRCh37	Chromosome 1, 65312347: 65312347
2	JAK1	NM_002227.3(JAK1): c.1972G> T (p.Val658Phe)	single nucleotide variant	Likely pathogenic	rs1057519753	GRCh38	Chromosome 1, 64846664: 64846664

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Expression for Leukemia, Acute, X-Linked

Search GEO for disease gene expression data for Leukemia, Acute, X-Linked.

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Pathways for Leukemia, Acute, X-Linked

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GO Terms for Leukemia, Acute, X-Linked

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⁷⁶ Wikipedia