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CLL
MCID: LKM071
MIFTS: 81

Leukemia, Chronic Lymphocytic (CLL)

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Leukemia, Chronic Lymphocytic

About this section

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic:

Name: Leukemia, Chronic Lymphocytic 57 74 38 40
Chronic Lymphocytic Leukemia 12 75 53 37 29 6 43 15 17 72
Cll 57 12 53 74
B-Cell Chronic Lymphocytic Leukemia 12 59 74
B-Cell Chronic Lymphoid Leukemia 12 59
Chronic Lymphatic Leukemia 12 74
Lymphoplasmacytic Leukemia 12 72
Small Lymphocytic Lymphoma 59 72
Leukemia, Lymphocytic, Chronic, B-Cell 44
Leukemia, Lymphocytic, Chronic 53
Leukemia Lymphocytic Chronic 55
Leukemia, Chronic Lymphatic 57
Lymphoma Small Lymphocytic 55
Chronic Lymphoid Leukemia 74
B-Cll 59

Characteristics:

Orphanet epidemiological data:

59
b-cell chronic lymphocytic leukemia
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (France); Age of onset: Adult;

OMIM:

57
Inheritance:
somatic mutation
autosomal dominant

Miscellaneous:
associated with susceptibility loci on chromosome 11p11 (clls1, ), 13q14 (clls2, ), 9q34.1 (clls3, ), 6p25.3 (clls4, ), and 11q24.1 (clls5, )


HPO:

32
leukemia, chronic lymphocytic:
Inheritance somatic mutation autosomal dominant somatic cell mutation


Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Bone diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:1040
OMIM 57 151400
KEGG 37 H00005
ICD9CM 35 204.1
MeSH 44 D015451
NCIt 50 C3163
SNOMED-CT 68 51092000 92814006
ICD10 33 C91.1 C91.10
MESH via Orphanet 45 D015451
ICD10 via Orphanet 34 C91.1
UMLS via Orphanet 73 C0023434 C0855095 C1868683
Orphanet 59 ORPHA67038
MedGen 42 C0023434
UMLS 72 C0023434 C0855095 C2854089
Sources

Summaries for Leukemia, Chronic Lymphocytic

About this section
MedlinePlus : 43 Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In chronic lymphocytic leukemia (CLL), there are too many lymphocytes, a type of white blood cell. CLL is the second most common type of leukemia in adults. It often occurs during or after middle age, and is rare in children. Usually CLL does not cause any symptoms. If you have symptoms, they may include Painless swelling of the lymph nodes in the neck, underarm, stomach, or groin Fatigue Pain or a feeling of fullness below the ribs Fever and infection Weight loss Tests that examine the blood, bone marrow, and lymph nodes diagnose CLL. Your doctor may choose to just monitor you until symptoms appear or change. Treatments include radiation therapy, chemotherapy, surgery to remove the spleen, and targeted therapy. Targeted therapy uses substances that attack cancer cells or block the growth and spread of cancer cells. NIH: National Cancer Institute

MalaCards based summary : Leukemia, Chronic Lymphocytic, also known as chronic lymphocytic leukemia, is related to leukemia, chronic lymphocytic 2 and lymphoma, non-hodgkin, familial, and has symptoms including fatigue, angina pectoris and edema. An important gene associated with Leukemia, Chronic Lymphocytic is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. The drugs Valganciclovir and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include Blood and Blood, and related phenotypes are cellular immunodeficiency and chronic lymphatic leukemia

Disease Ontology : 12 A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood.

NIH Rare Diseases : 53 Chronic lymphocytic leukemia (CLL) is a cancer of the lymphocytes (a type of white blood cell). It begins in the stem cells of the bone marrow and then spreads to the blood. Over time, CLL may also spread to the lymph nodes and other organs, including the liver, spleen and lungs. Early signs and symptoms of CLL may include swollen lymph nodes, fatigue, weight loss, loss of appetite, fever, night sweats and/or frequent infections. The underlying cause of CLL is unknown. It usually occurs in people with no family history of the condition, but familial cases have been reported. Treatment options depend on many factors, including the stage of the condition, blood cell counts, and whether the CLL has recurred (come back). Treatment may not be necessary until a person develops symptoms or there is other evidence of rapid cancer progression. The chance of recovery and life expectancy vary from person to person. While most people with CLL live at least 5 to 10 years, some do not survive more than 2 to 3 years after the diagnosis.

OMIM : 57 Chronic lymphocytic leukemia (CLL) is a common neoplasia of B lymphocytes in which these cells progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival (summary by Quesada et al., 2012). (151400)

KEGG : 37
Chronic lymphocytic leukemia (CLL) is caused by the abnormal progressive accumulation of functionally incompetent monoclonal B-lymphocytes in blood, bone marrow, lymph nodes and spleen. It is the most common adult leukemia in Western countries, accounting for about 30% of total leukaemias. Worldwide there are approximately 180,000 new cases every year. A main focus in CLL research involved the evaluation of genetic features related to somatic gene mutation or deletions that disrupt apoptosis and enhance tumor cell proliferation. The best characterized genes are TP53 (also known as p53) and ATM, for which mutations and/or deletions have been described that predict rapid disease progression, resistance to conventional therapies and poor survival.

UniProtKB/Swiss-Prot : 74 Leukemia, chronic lymphocytic: A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.

Wikipedia : 75 Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many... more...

Sources

Related Diseases for Leukemia, Chronic Lymphocytic

About this section

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 943)
# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 2 36.4 TP53 PTPN11 NRAS MIR34A MIR29A MIR181A2
2 lymphoma, non-hodgkin, familial 32.6 TP53 NRAS CCND1 BRAF ATM
3 mantle cell lymphoma 32.5 TP53 MIR16-1 CCND1 ATM
4 myeloma, multiple 32.5 TP53 PTPN11 NRAS MIR181A2 MIR15A MIR106B
5 colorectal cancer 32.4 TP53 NRAS MIR34A MIR29A MIR181A2 MIR143
6 prostate cancer 32.3 TP53 MIR34A MIR29A MIR16-1 MIR15A MIR143
7 melanoma 32.3 TP53 NRAS MIR34A MIR181A2 MIR15A MIR107
8 lung cancer 32.2 TP53 NRAS MIR34A MIR29A MIR15A MIR143
9 leukemia, acute myeloid 32.2 TP53 PTPN11 NRAS MIR181A2 KRAS HRAS
10 myeloid leukemia 32.2 TP53 PTPN11 NRAS HRAS
11 lung cancer susceptibility 3 32.1 TP53 NRAS KRAS HRAS CCND1 BRAF
12 adenoma 32.0 TP53 KRAS CCND1 BRAF
13 kidney cancer 32.0 TP53 MIR29A MIR15A MIR106B
14 glioma 32.0 TP53 POT1 MIR34A MIR181A2 MIR15A CCND1
15 gastric cancer 32.0 TP53 MIR34A MIR143 MIR107 MIR106B KRAS
16 hepatocellular carcinoma 32.0 TP53 NRAS MIR34A MIR29A MIR181A2 MIR15A
17 thyroid cancer, nonmedullary, 1 31.9 MIR34A MIR29A MIR181A2 MIR15A BRAF
18 cll/sll 31.9 TP53 CCND1 ATM
19 adenocarcinoma 31.9 TP53 KRAS HRAS CCND1 BRAF
20 esophageal cancer 31.9 TP53 MIR34A MIR107 KRAS HRAS CCND1
21 squamous cell carcinoma, head and neck 31.8 TP53 MIR15A HRAS CCND1 BRAF
22 glioblastoma 31.8 TP53 NRAS MIR34A MIR181A2 HRAS CCND1
23 noonan syndrome 1 31.7 PTPN11 NRAS KRAS HRAS BRAF
24 gastric adenocarcinoma 31.7 TP53 NRAS KRAS HRAS CCND1 BRAF
25 myelodysplastic syndrome 31.7 TP53 PTPN11 NRAS MIR34A KRAS HRAS
26 melanoma, cutaneous malignant 1 31.7 TP53 POT1 NRAS HRAS BRAF
27 hematologic cancer 31.7 TP53 PTPN11 HRAS ATM
28 brain cancer 31.6 TP53 PTPN11 NRAS HRAS BRAF
29 gastrointestinal stromal tumor 31.5 TP53 KRAS CCND1 BRAF
30 oral squamous cell carcinoma 31.5 MIR34A MIR29A MIR143 MIR107
31 breast cancer 31.5 TP53 MIR34A MIR181A2 MIR143 KRAS HRAS
32 lung benign neoplasm 31.5 TP53 KRAS HRAS
33 skin melanoma 31.4 TP53 NRAS BRAF
34 bladder cancer 31.4 TP53 MIR143 KRAS HRAS CCND1
35 transitional cell carcinoma 31.3 TP53 HRAS BRAF
36 endometrial cancer 31.2 TP53 KRAS HRAS CCND1 BRAF
37 nasopharyngeal carcinoma 31.0 TP53 NRAS HRAS CCND1
38 leukemia, chronic lymphocytic 4 12.6
39 leukemia, chronic lymphocytic 5 12.6
40 leukemia, chronic lymphocytic 1 12.5
41 leukemia, chronic lymphocytic 3 12.5
42 leukemia 11.8
43 pancreatic cancer 11.5 TP53 MIR34A MIR181A2 MIR16-1 MIR15A MIR143
44 large intestine cancer 11.4 TP53 PTPN11 NRAS KRAS HRAS CCND1
45 ovarian cancer 11.4 TP53 MIR29A MIR143 MIR106B KRAS CCND1
46 bladder urothelial carcinoma 11.4 TP53 NRAS KRAS HRAS CCND1 BRAF
47 differentiated thyroid carcinoma 11.4 TP53 NRAS KRAS HRAS BRAF
48 renal cell carcinoma, papillary, 1 11.4 TP53 NRAS HRAS BRAF ATM
49 lung squamous cell carcinoma 11.3 TP53 PTPN11 KRAS HRAS BRAF
50 liver angiosarcoma 11.3 TP53 NRAS KRAS HRAS

Comorbidity relations with Leukemia, Chronic Lymphocytic via Phenotypic Disease Network (PDN): (show all 12)


Acquired Thrombocytopenia Acute Cystitis
Agammaglobulinemia, X-Linked Anemia, Autoimmune Hemolytic
Bronchitis Chronic Leukemia
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Leukemia Neutropenia

Graphical network of the top 20 diseases related to Leukemia, Chronic Lymphocytic:



Diseases related to Leukemia, Chronic Lymphocytic
Sources

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic

About this section

Human phenotypes related to Leukemia, Chronic Lymphocytic:

32
# Description HPO Frequency HPO Source Accession
1 cellular immunodeficiency 32 HP:0005374
2 chronic lymphatic leukemia 32 HP:0005550

Symptoms via clinical synopsis from OMIM:

57
Hematology:
chronic lymphatic leukemia

Laboratory Abnormalities:
recurring t(11,14) and t(14,19)(q32,q13.1) translocations

Immunology:
impaired cellular and humoral immunity

Clinical features from OMIM:

151400

UMLS symptoms related to Leukemia, Chronic Lymphocytic:


fatigue, angina pectoris, edema, chest pain

GenomeRNAi Phenotypes related to Leukemia, Chronic Lymphocytic according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ATM BRAF CCND1 HRAS KRAS NRAS

MGI Mouse Phenotypes related to Leukemia, Chronic Lymphocytic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.87 BRAF CCND1 HRAS KRAS NRAS PTPN11
2 digestive/alimentary MP:0005381 9.8 BRAF CCND1 HRAS KRAS NRAS PTPN11
3 integument MP:0010771 9.76 ATM BRAF CCND1 HRAS KRAS NRAS
4 neoplasm MP:0002006 9.61 ATM BRAF CCND1 HRAS IKZF3 KRAS
5 pigmentation MP:0001186 9.02 BRAF KRAS NRAS PTPN11 TP53
Sources

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic

About this section

Drugs for Leukemia, Chronic Lymphocytic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 546)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valganciclovir Approved, Investigational Phase 4 175865-60-8 64147
2
Pancrelipase Approved, Investigational Phase 4 53608-75-6
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
5
Chlorambucil Approved Phase 4 305-03-3 2708
6 Immunologic Factors Phase 4
7 Vaccines Phase 4
8 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
9 pancreatin Phase 4
10 Hydrocortisone 17-butyrate 21-propionate Phase 4
11 Hydrocortisone hemisuccinate Phase 4
12 Hematinics Phase 4
13 Epoetin alfa Phase 4 113427-24-0
14 Orange Approved Phase 3
15
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
16
Pixantrone Approved, Investigational Phase 3 144510-96-3
17
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
18
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
19
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
20
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
21
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
22
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
23
Ondansetron Approved Phase 3 99614-02-5 4595
24
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
25
Dalteparin Approved Phase 3 9005-49-6
26
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
27
Tazobactam Approved Phase 3 89786-04-9 123630
28
Piperacillin Approved Phase 3 66258-76-2 43672
29
Vancomycin Approved Phase 3 1404-90-6 441141 14969
30
Ribavirin Approved Phase 3 36791-04-5 37542
31
Palivizumab Approved, Investigational Phase 3 188039-54-5
32
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
33
Captopril Approved Phase 3 62571-86-2 44093
34
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
35
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
36
Morphine Approved, Investigational Phase 3 57-27-2 5288826
37
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
38
Acyclovir Approved Phase 3 59277-89-3 2022
39
Ofloxacin Approved Phase 3 82419-36-1 4583
40
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
41
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
42
Obinutuzumab Approved, Investigational Phase 3 949142-50-1
43
Phylloquinone Approved, Investigational Phase 3 84-80-0
44
ofatumumab Approved Phase 3 679818-59-8 6918251
45
Idelalisib Approved Phase 3 870281-82-6
46
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
47
Iodine Approved, Investigational Phase 3 7553-56-2 807
48
Mycophenolic acid Approved Phase 3 24280-93-1 446541
49
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
50
leucovorin Approved Phase 3 58-05-9 143 6006

Interventional clinical trials:

(show top 50) (show all 1822)
# Name Status NCT ID Phase Drugs
1 A Multicenter, Open-Label Study of Nipent, Cytoxan and Rituxan in Patients With Previously Untreated or Treated Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
2 Evaluation of the Immune Response After Vaccination Against Hepatitis B in Patients With Indolent Lymphoproliferative Disorders With no Treatment. Unknown status NCT01698866 Phase 4
3 1-Year Longitudinal Follow-up Study of Serologic Responses to 7-valent Pneumococcal Conjugated Vaccination and Opsonophagocytic Activities for Streptococcus Pneumoniae Among Patients With Human Immunodeficiency Virus Infection Unknown status NCT00885625 Phase 4
4 A Single-arm, International, Multi-center Trial Investigating the Efficacy and Safety of Ofatumumab Retreatment and Maintenance in CLL Patients Who Progressed Following Response or Stable Disease After Ofatumumab Treatment in Hx-CD20-406 Completed NCT00802737 Phase 4 Ofatumumab
5 A Multicenter Study to Confirm the Efficacy and Safety of Fludara i.v. (Fludarabine Phosphate, SH L 573), Administered in 6 Treatment Cycles (1 Treatment Cycle: 5-consecutive Day Dosing, Followed by an Observation Period of 23 Days) in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
6 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
7 Treatment of Chronic Lymphocytic Leukemia With the Use of an Antiviral Compound - a Proof of Principle Study Completed NCT01255644 Phase 4 Valganciclovir
8 A Randomized Study to Assess the Effect on Response Rate of MabThera (Rituximab) Added to a Standard Chemotherapy, Bendamustine or Chlorambucil, in Patients With Chronic Lymphocytic Leukemia Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
9 Alemtuzumab Versus Thymoglobulin Induction Therapy in Kidney and Pancreas Transplantation Completed NCT00331162 Phase 4 Alemtuzumab;Anti-Thymocyte Globulin
10 Evaluation of Allogeneic Marrow Transplants Depleted of T-Cells by CD34+ Selection in Patients Undergoing Transplantation With an Unrelated Matched or 1 Antigen Mismatched Donor or a 1 Antigen Mismatched Related Donor Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
11 The Effects of PROCRIT (Epoetin Alfa) on Hemoglobin, Symptom Distress, and Quality of Life During Chemotherapy in Lymphoma, Chronic Lymphocytic Leukemia or Multiple Myeloma Patients With Mild to Moderate Anemia Completed NCT00524407 Phase 4 Epoetin alfa
12 Study Evaluating Rapid Infusion Rituximab in Patients With Autoimmune Diseases Completed NCT02040116 Phase 4 Rituximab Infusion
13 A Prospective, Multicenter, Open Label Single Arm Phase IV Clinical Trial to Assess Safety of ImbruvicaTM (Ibrutinib Capsules 140 mg) in Indian Patients With Chronic Lymphocytic Leukemia or Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy or Chronic Lymphocytic Leukemia With 17p Deletion Recruiting NCT03190330 Phase 4 Ibrutinib 420 mg;Ibrutinib 560 mg
14 Prospective Study of Efficacy and Safety of RFC (Rituximab, Fludarabine, Cyclophosphamide) Regimen as a First-Line Therapy in Patients With B-Cell Chronic Lymphocytic Leukemia and Favorable Somatic Status Terminated NCT01271010 Phase 4 Cyclophosphamide;Fludarabine;Rituximab
15 Prospective Randomized Study to Compare Efficacy and Safety of RFC-Lite (Rituximab, Fludarabine, Cyclophosphamide) Regimen With LR (Rituximab, Chlorambucil) as a First-Line Therapy in Patients With B-Cell Chronic Lymphocytic Leukemia and Unfavorable Somatic Status Terminated NCT01283386 Phase 4 Chlorambucil;Cyclophosphamide;Fludarabine;Rituximab
16 Open Multicentric Study to Assess the Hematopoyetic Response in Terms of Increase of Hemoglobin Levels of Patients With Anemia Related to Non- Hodgkin Lymphoma, Chronic Lymphocytic Leukemia or Multiple Myeloma, Treated With Erythropoietin B (Recormon) Using Pre-filled Syringe With 30000 IU, as Well as to Quantify the Risk Factors of Anemia and Its Impact on Quality of Life Related to Treatment Terminated NCT02608060 Phase 4 Epoetin Beta
17 Clinical Study of Chemoimmunotherapy With Fresh Frozen Plasma, High Dose Methylprednisolone and Rituximab for Ultra-high Risk Chronic Lymphocytic Leukemia Unknown status NCT01670812 Phase 3 FFP+HDMP+Rituximab
18 Study of Bendamustine Hydrochloride Injection in Previously Untreated Chronic Lymphocytic Leukemia Patients Unknown status NCT01657955 Phase 3 Bendamustine Hydrochloride Injection;Chlorambucil
19 Combination of Ibrutinib and As2O3 in the Treatment of CLL Unknown status NCT02757040 Phase 3 Ibrutinib combined with As2O3;ibrutinib
20 Low Dose Chlorambucil Maintenance Vs. No Treatment Following High-Dose Chlorambucil Induction In Patients With Advanced B-Chronic Lymphocytic Leukemia. A Randomized Phase III Study Of The EORTC LG (CLL-3) Unknown status NCT00017108 Phase 3 chlorambucil;cyclophosphamide;fludarabine phosphate
21 Phase III, Controlled, Double-blind, Randomized Study of 25-OH-Vitamin-D3 Substitution in Patients With Malignant and Immune-hematologic Diseases Unknown status NCT01518959 Phase 3 Cholecalciferol;oleum neutralicum
22 A Randomised Investigation of Alternative Ofatumumab-containing Regimens in Less Fit Patients With CLL Unknown status NCT01678430 Phase 3 Ofatumumab;Chlorambucil;Bendamustine
23 Randomized Controlled Study of Iron Supplementation to Support the Response to Recombinant Human Erythropoietin for the Treatment of Chemotherapy-Induced Anaemia Unknown status NCT00482716 Phase 3
24 A Randomized Phase III Trial Comparing the Combination of Fludarabine, BBR 2778 (Pixantrone) and Rituximab (FP-R) With the Combination of Fludarabine and Rituximab (F-R) in the Treatment of Patients With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma Unknown status NCT00551239 Phase 3 fludarabine phosphate;pixantrone dimaleate
25 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
26 A Randomized Phase III Study to Assess Intensification of the Conditioning Regimen for Allogenic Stem Cell Transplantation (ALLO-SCT) for Leukemia or Myelodysplastic Syndrome With a High Risk of Relapse Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
27 A Randomized Trial of Thymoglobulin to Prevent Chronic Graft Versus Host Disease in Patients Undergoing Hematopoietic Progenitor Cell Transplantation (HPCT) From Unrelated Donors Unknown status NCT01217723 Phase 3
28 Randomised Controlled Trial of CID (Chlorambucil, Idarubicin, Dexamethasone) Versus CD (Chlorambucil, Dexamethasone) for Induction of Remission in Low Grade Non-Hodgkin's Lymphoma (Kiel Classification) Followed by Randomised Controlled Assessment of Standard Dose Interferon Versus Low Dose Interferon Versus No Further Therapy as Maintenance Treatment After Remission Induction Unknown status NCT00003639 Phase 3 chlorambucil;dexamethasone;idarubicin
29 The Utility of LymphoScan Imaging in the Dectection of Residual Tumor After Chemotherapy and/or Radiotherapy in Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
30 The Utility of LymphoScan Imaging in the Localization and Staging of Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003337 Phase 3
31 A Prospective Randomised Phase III Trial of Early Hospital Discharge Versus Standard Inpatient Management of Cancer Patients With Low-Risk Febrile Neutropenia Receiving Oral Antibiotics. Oral Antibiotics for Neutropenic Sepsis Giving Early Hospital Discharge [ORANGE] Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
32 A European Randomized Multicenter Study of Interferon Alfa-2b Versus No Treatment After Intensive Therapy and Autologous Hematopoietic Stem Cell Transplantation for Relapsing Lymphoma Patients (Non-Hodgkin Lymphomas and Hodgkin's Disease) Unknown status NCT00003924 Phase 3
33 Phase III Trial of Combined Immunochemotherapy With Fludarabine, Cyclophosphamide and Rituximab (FCR) Versus Chemotherapy With Fludarabine and Cyclophosphamide (FC) Alone in Patients With Previously Untreated Chronic Lymphocytic Leukaemia Completed NCT00281918 Phase 3 Rituximab;Cyclophosphamide;Fludarabine Phosphate
34 A Phase III Study to Evaluate the Efficacy and Safety of Front-Line Therapy With Alemtuzumab (Campath, MabCampath) vs Chlorambucil in Patients With Progressive B-Cell Chronic Lymphocytic Leukemia Completed NCT00046683 Phase 3 alemtuzumab
35 A Prospective, Randomized, Open Label, Phase III Trial of Fludarabine, Cyclophosphamide, and Rituximab vs. Pentostatin, Cyclophosphamide, and Rituximab in Previously Untreated or Treated B-cell Chronic Lymphocytic Leukemia Completed NCT00254163 Phase 3 Fludarabine;Cyclophosphamide;Rituximab;Pentostatin
36 Prognostic Factors and Risk-Adapted Therapy in Patients With Early Stage Chronic Lymphocytic Leukemia Completed NCT00262782 Phase 3 Fludarabine
37 A Phase III Randomized Trial to Evaluate the Efficacy and Safety of Second-Line Therapy With Fludarabine Plus Alemtuzumab vs. Fludarabine Alone in Patients With B-Cell Chronic Lymphocytic Leukemia Completed NCT00086580 Phase 3
38 A Randomized, Multicenter, Open-Label, Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 (Ibrutinib) Versus Rituximab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Completed NCT01973387 Phase 3 Rituximab;Ibrutinib
39 Randomized, Double-blind, Placebo-controlled Phase 3 Study of Ibrutinib, a Bruton's Tyrosine Kinase (BTK) Inhibitor, in Combination With Bendamustine and Rituximab (BR) in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Completed NCT01611090 Phase 3 Ibrutinib;Bendamustine hydrochloride;Rituximab;Placebo
40 A Randomized, Multicenter, Open-label, Phase 3 Study of the Bruton's Tyrosine Kinase (BTK) Inhibitor Ibrutinib (PCI-32765) Versus Ofatumumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Completed NCT01578707 Phase 3 ofatumumab;ibrutinib
41 Phase III Randomized Trial of Fludarabine and Cyclophosphamide Versus Fludarabine for Previously Untreated Chronic Lymphocytic Leukemia Completed NCT00003764 Phase 3 cyclophosphamide;fludarabine phosphate
42 Chronic Lymphocytic Leukemia Trial 4: A Randomized Comparison of Chlorambucil, Fludarabine and Fludarabine Plus Cyclophosphamide Completed NCT00004218 Phase 3 chlorambucil;cyclophosphamide;doxorubicin hydrochloride;fludarabine phosphate;prednisolone;vincristine sulfate
43 Randomized Phase III Trial Evaluating the Role of Autologous Stem Cell Transplantation in Previously Untreated Patients With Stage B and C Chronic Lymphocytic Leukemia Completed NCT00931645 Phase 3
44 A Phase 3, Multicenter, Randomized, Openlabel, Parallel-Group Study of the Efficacy and Safety of Lenalidomide (Revlimid®) Versus Chlorambucil as First-Line Therapy for Previously Untreated Elderly Patients With B-Cell Chronic Lymphocytic Leukemia (The Origin Trial) Completed NCT00910910 Phase 3 Lenalidomide;Chlorambucil
45 Randomized Phase-III Trial Comparing Fludarabine and Cyclophosphamide Plus Rituximab (FCR) to FC and MabCampath (FCCam) for Previously Untreated Fit Patients With Chronic Lymphocytic Leukemia (CLL) Completed NCT00564512 Phase 3 cyclophosphamide;fludarabine
46 Phase III Trial of Combined Immunochemotherapy With Fludarabine, Cyclophosphamide and Rituximab (FCR) Versus Bendamustine and Rituximab (BR) in Patients With Previously Untreated Chronic Lymphocytic Leukaemia Completed NCT00769522 Phase 3 Bendamustine;Cyclophosphamide;Fludarabine
47 A Randomized Phase III Trial to Determine Whether Conjugated Pneumococcal Vaccine Can Improve the Immune Responsiveness Compared to Polyclonal Pneumococcal Vaccine in Patients With Untreated Chronic Lymphocytic Leukemia Completed NCT01892618 Phase 3 Prevenar 13;Pneumovax
48 Open-label, Multicenter, Randomized, Comparative, Phase III Study to Evaluate the Efficacy and Safety of FCR vs. FC Alone in Previously Treated Patients With CD20 Positive B-cell CLL Completed NCT00090051 Phase 3 Rituximab;Fludarabine Phosphate;Cyclophosphamide
49 A Randomized, Open Label Study to Assess the Effect of Maintenance Treatment With Mabthera (Rituximab) Versus No Treatment, After Induction Treatment With Rituximab, Cladribine and Cyclophosphamide (RCC) on Progression-Free Survival in Previously Untreated Patients With Progressive B-Cell Chronic Lymphocytic Leukemia Completed NCT00718549 Phase 3 Cladribine;Cyclophosphamide;Rituximab
50 Randomized Phase III Trial Comparing Early Treatment With Fludarabine/Cyclophosphamide + Rituximab Versus Deferred Treatment in Untreated Binet Stage A Patients With CLL and High Risk of Progression Completed NCT00275054 Phase 3 Fludarabine;Cyclophosphamide

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic

Inferred drug relations via UMLS 72 / NDF-RT 51 :


alemtuzumab
Alemtuzumab
Bendamustine
Chlorambucil
Chlorambucil
Cladribine
Cladribine
Cyclophosphamide
Cyclophosphamide
etoposide phosphate
fludarabine
Fludarabine phosphate
Hyaluronidase (ovine)
Ibrutinib
Ibrutinib
Ifosfamide
Immune Globulin Human
Immunoglobulins, Intravenous
Mechlorethamine
mercaptopurine
Ofatumumab
pegaspargase
Pentostatin
Rituximab
Uracil Mustard
Venetoclax
Vincristine

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Leukemia, Chronic Lymphocytic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Leukemia, Chronic Lymphocytic:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Leukemia, Chronic Lymphocytic:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: leukemia, lymphocytic, chronic, b-cell

Sources

Genetic Tests for Leukemia, Chronic Lymphocytic

About this section

Genetic tests related to Leukemia, Chronic Lymphocytic:

# Genetic test Affiliating Genes
1 Chronic Lymphocytic Leukemia 29
Sources

Anatomical Context for Leukemia, Chronic Lymphocytic

About this section

MalaCards organs/tissues related to Leukemia, Chronic Lymphocytic:

41
B Cells, T Cells, Bone, Bone Marrow, Myeloid, Lymph Node, Spleen
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Leukemia, Chronic Lymphocytic:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Blood Peripheral Blood Mature B-Cells Affected by disease
3 Blood Hematopoietic Bone Marrow Small Pre B-Cells Affected by disease
Sources

Publications for Leukemia, Chronic Lymphocytic

About this section

Articles related to Leukemia, Chronic Lymphocytic:

(show top 50) (show all 15682)
# Title Authors PMID Year
1
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. 38 88 8
16251535 2005
2
miR-15 and miR-16 induce apoptosis by targeting BCL2. 38 88 8
16166262 2005
3
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. 9 38 8
12595313 2003
4
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. 9 38 8
12724482 2003
5
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 38 8
23770605 2013
6
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. 38 8
22150006 2011
7
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. 38 8
22158541 2011
8
Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL. 38 8
21131588 2011
9
Karyotype-specific microRNA signature in chronic lymphocytic leukemia. 9 38 88
19717645 2009
10
Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia. 38 8
17047154 2007
11
HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses. 38 8
15931393 2005
12
Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish Family-Cancer Database. 38 8
15161669 2004
13
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. 38 8
14973191 2004
14
Cytogenetic findings in familial B-cell chronic lymphocytic leukemia: a report of two cases in a family. 38 8
12781453 2003
15
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. 38 8
12434020 2002
16
Hereditary chronic lymphocytic leukemia: an extended family study and literature review. 38 8
12407690 2002
17
Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. 38 8
11090088 2000
18
Genomic aberrations and survival in chronic lymphocytic leukemia. 38 8
11136261 2000
19
Anticipation in familial chronic lymphocytic leukemia. 38 8
10364544 1999
20
Anticipation in familial leukemia. 38 8
8900225 1996
21
Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia. 38 8
3120193 1987
22
Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia. 38 8
3122218 1987
23
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. 38 8
6610211 1984
24
Familial chronic lymphocytic leukemia. 38 8
6418939 1983
25
Genetic factors predisposing to chronic lymphocytic leukemia and to autoimmune disease. 38 8
7001171 1980
26
Familial chronic lymphocytic leukemia. Immunologic and cellular characterization. 38 8
818930 1976
27
Familial chronic lymphocytic leukemia. 38 8
4184386 1969
28
Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia. 38 17
31365801 2019
29
Paraoxonase 1 (PON1) Q192R and L55M Polymorphisms as Potential Predisposition Factors for Chronic Lymphocytic Leukemia. 38 17
31177124 2019
30
Non-coding recurrent mutations in chronic lymphocytic leukaemia. 8
26200345 2015
31
Mutations driving CLL and their evolution in progression and relapse. 8
26466571 2015
32
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia. 8
21642962 2011
33
Aberrant microRNA expression in Chinese patients with chronic lymphocytic leukemia. 38 88
21130495 2011
34
Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. 38 88
20566844 2010
35
microRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia. 38 88
20089965 2010
36
miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia. 38 88
19692702 2009
37
microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk stratification. 38 88
19144983 2009
38
Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. 38 88
19096009 2009
39
MiR-15a and miR-16-1 cluster functions in human leukemia. 38 88
18362358 2008
40
Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis. 38 88
17989717 2008
41
The role of microRNA and other non-coding RNA in the pathogenesis of chronic lymphocytic leukemia. 38 88
17707831 2007
42
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia. 38 88
17327404 2007
43
Trinucleotide repeat dynamic mutation identifying susceptibility in familial and sporadic chronic lymphocytic leukaemia. 8
17116127 2007
44
Familial cancer associated with a polymorphism in ARLTS1. 8
15843669 2005
45
Predicting Progression--ZAP-70 in CLL. 8
15329421 2004
46
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. 38 88
15284443 2004
47
MicroRNAs: genomics, biogenesis, mechanism, and function. 8
14744438 2004
48
Molecular diagnosis of the hematologic cancers. 8
12724484 2003
49
A loss-of-function polymorphic mutation in the cytolytic P2X7 receptor gene and chronic lymphocytic leukaemia: a molecular study. 8
11943260 2002
50
Anterior chamber infiltrates associated with systemic lymphoma: report of two cases and review of the literature. 8
11825804 2002
Sources

Variations for Leukemia, Chronic Lymphocytic

About this section

ClinVar genetic disease variations for Leukemia, Chronic Lymphocytic:

6 (show top 50) (show all 104)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 NRAS NM_002524.5(NRAS): c.183A> T (p.Gln61His) single nucleotide variant Pathogenic rs121913255 1:115256528-115256528 1:114713907-114713907
2 TP53 NM_000546.5(TP53): c.712T> C (p.Cys238Arg) single nucleotide variant Pathogenic rs1057519981 17:7577569-7577569 17:7674251-7674251
3 TP53 NM_000546.5(TP53): c.713G> T (p.Cys238Phe) single nucleotide variant Pathogenic rs730882005 17:7577568-7577568 17:7674250-7674250
4 TP53 NM_000546.5(TP53): c.841G> T (p.Asp281Tyr) single nucleotide variant Pathogenic rs764146326 17:7577097-7577097 17:7673779-7673779
5 TP53 NM_000546.5(TP53): c.841G> A (p.Asp281Asn) single nucleotide variant Pathogenic rs764146326 17:7577097-7577097 17:7673779-7673779
6 TP53 NM_000546.5(TP53): c.818G> T (p.Arg273Leu) single nucleotide variant Pathogenic rs28934576 17:7577120-7577120 17:7673802-7673802
7 TP53 NM_000546.5(TP53): c.742C> T (p.Arg248Trp) single nucleotide variant Pathogenic rs121912651 17:7577539-7577539 17:7674221-7674221
8 TP53 NM_000546.5(TP53): c.725G> A (p.Cys242Tyr) single nucleotide variant Pathogenic rs121912655 17:7577556-7577556 17:7674238-7674238
9 HRAS NM_005343.4(HRAS): c.37G> T (p.Gly13Cys) single nucleotide variant Pathogenic rs104894228 11:534286-534286 11:534286-534286
10 NRAS NM_002524.5(NRAS): c.182A> G (p.Gln61Arg) single nucleotide variant Pathogenic rs11554290 1:115256529-115256529 1:114713908-114713908
11 BRAF NM_004333.6(BRAF): c.1801A> G (p.Lys601Glu) single nucleotide variant Pathogenic rs121913364 7:140453134-140453134 7:140753334-140753334
12 BRAF NM_004333.6(BRAF): c.1781A> G (p.Asp594Gly) single nucleotide variant Pathogenic rs121913338 7:140453154-140453154 7:140753354-140753354
13 TP53 NM_000546.5(TP53): c.842A> G (p.Asp281Gly) single nucleotide variant Pathogenic rs587781525 17:7577096-7577096 17:7673778-7673778
14 TP53 NM_000546.5(TP53): c.584T> C (p.Ile195Thr) single nucleotide variant Pathogenic rs760043106 17:7578265-7578265 17:7674947-7674947
15 NRAS NM_002524.5(NRAS): c.182A> C (p.Gln61Pro) single nucleotide variant Pathogenic rs11554290 1:115256529-115256529 1:114713908-114713908
16 TP53 NM_000546.5(TP53): c.824G> A (p.Cys275Tyr) single nucleotide variant Pathogenic/Likely pathogenic rs863224451 17:7577114-7577114 17:7673796-7673796
17 TP53 NM_000546.5(TP53): c.818G> C (p.Arg273Pro) single nucleotide variant Pathogenic/Likely pathogenic rs28934576 17:7577120-7577120 17:7673802-7673802
18 PTPN11 NM_002834.4(PTPN11): c.214G> A (p.Ala72Thr) single nucleotide variant Pathogenic/Likely pathogenic rs121918453 12:112888198-112888198 12:112450394-112450394
19 HRAS NM_005343.4(HRAS): c.38G> T (p.Gly13Val) single nucleotide variant Pathogenic/Likely pathogenic rs104894226 11:534285-534285 11:534285-534285
20 TP53 NM_000546.5(TP53): c.842A> T (p.Asp281Val) single nucleotide variant Pathogenic/Likely pathogenic rs587781525 17:7577096-7577096 17:7673778-7673778
21 HRAS NM_005343.4(HRAS): c.37G> C (p.Gly13Arg) single nucleotide variant Pathogenic/Likely pathogenic rs104894228 11:534286-534286 11:534286-534286
22 BRAF NM_004333.6(BRAF): c.1802A> C (p.Lys601Thr) single nucleotide variant Pathogenic/Likely pathogenic rs397507484 7:140453133-140453133 7:140753333-140753333
23 KRAS NM_004985.5(KRAS): c.183A> T (p.Gln61His) single nucleotide variant Pathogenic/Likely pathogenic rs17851045 12:25380275-25380275 12:25227341-25227341
24 TP53 NM_000546.5(TP53): c.817C> A (p.Arg273Ser) single nucleotide variant Pathogenic/Likely pathogenic rs121913343 17:7577121-7577121 17:7673803-7673803
25 TP53 NM_000546.5(TP53): c.743G> A (p.Arg248Gln) single nucleotide variant Pathogenic/Likely pathogenic rs11540652 17:7577538-7577538 17:7674220-7674220
26 TP53 NM_000546.5(TP53): c.818G> A (p.Arg273His) single nucleotide variant Pathogenic/Likely pathogenic rs28934576 17:7577120-7577120 17:7673802-7673802
27 TP53 NM_000546.5(TP53): c.523C> G (p.Arg175Gly) single nucleotide variant Pathogenic/Likely pathogenic rs138729528 17:7578407-7578407 17:7675089-7675089
28 NRAS NM_002524.5(NRAS): c.182A> T (p.Gln61Leu) single nucleotide variant Pathogenic/Likely pathogenic rs11554290 1:115256529-115256529 1:114713908-114713908
29 BRAF NM_004333.6(BRAF): c.1780G> C (p.Asp594His) single nucleotide variant Pathogenic/Likely pathogenic rs397516896 7:140453155-140453155 7:140753355-140753355
30 SF3B1 NM_012433.3(SF3B1): c.1996A> G (p.Lys666Glu) single nucleotide variant Likely pathogenic rs754688962 2:198267361-198267361 2:197402637-197402637
31 HRAS ; LRRC56 NM_005343.4(HRAS): c.182A> T (p.Gln61Leu) single nucleotide variant Likely pathogenic rs121913233 11:533874-533874 11:533874-533874
32 BTK NM_000061.2(BTK): c.1441T> A (p.Cys481Ser) single nucleotide variant Likely pathogenic rs1057519826 X:100611165-100611165 X:101356177-101356177
33 PLCG2 NM_002661.5(PLCG2): c.1993C> T (p.Arg665Trp) single nucleotide variant Likely pathogenic rs1057519831 16:81946260-81946260 16:81912655-81912655
34 PLCG2 NM_002661.5(PLCG2): c.2535A> C (p.Leu845Phe) single nucleotide variant Likely pathogenic rs1057519832 16:81962183-81962183 16:81928578-81928578
35 PLCG2 NM_002661.5(PLCG2): c.2535A> T (p.Leu845Phe) single nucleotide variant Likely pathogenic rs1057519832 16:81962183-81962183 16:81928578-81928578
36 BRAF NM_004333.6(BRAF): c.1803A> C (p.Lys601Asn) single nucleotide variant Likely pathogenic rs121913365 7:140453132-140453132 7:140753332-140753332
37 HRAS ; LRRC56 NM_005343.4(HRAS): c.182A> C (p.Gln61Pro) single nucleotide variant Likely pathogenic rs121913233 11:533874-533874 11:533874-533874
38 FBXW7 NM_018315.5(FBXW7): c.1153C> T (p.Arg385Cys) single nucleotide variant Likely pathogenic rs867384286 4:153249385-153249385 4:152328233-152328233
39 FBXW7 NM_018315.5(FBXW7): c.1154G> A (p.Arg385His) single nucleotide variant Likely pathogenic rs1057519895 4:153249384-153249384 4:152328232-152328232
40 FBXW7 NM_018315.5(FBXW7): c.1154G> C (p.Arg385Pro) single nucleotide variant Likely pathogenic rs1057519895 4:153249384-153249384 4:152328232-152328232
41 FBXW7 NM_018315.5(FBXW7): c.1154G> T (p.Arg385Leu) single nucleotide variant Likely pathogenic rs1057519895 4:153249384-153249384 4:152328232-152328232
42 FBXW7 NM_018315.5(FBXW7): c.1153C> G (p.Arg385Gly) single nucleotide variant Likely pathogenic rs867384286 4:153249385-153249385 4:152328233-152328233
43 FBXW7 NM_018315.5(FBXW7): c.1273C> G (p.Arg425Gly) single nucleotide variant Likely pathogenic rs149680468 4:153247289-153247289 4:152326137-152326137
44 FBXW7 NM_018315.5(FBXW7): c.1274G> T (p.Arg425Leu) single nucleotide variant Likely pathogenic rs1057519896 4:153247288-153247288 4:152326136-152326136
45 TP53 NM_000546.5(TP53): c.713G> C (p.Cys238Ser) single nucleotide variant Likely pathogenic rs730882005 17:7577568-7577568 17:7674250-7674250
46 TP53 NM_000546.5(TP53): c.726C> G (p.Cys242Trp) single nucleotide variant Likely pathogenic rs375874539 17:7577555-7577555 17:7674237-7674237
47 TP53 NM_000546.5(TP53): c.712T> G (p.Cys238Gly) single nucleotide variant Likely pathogenic rs1057519981 17:7577569-7577569 17:7674251-7674251
48 FBXW7 NM_018315.5(FBXW7): c.1273C> A (p.Arg425Ser) single nucleotide variant Likely pathogenic rs149680468 4:153247289-153247289 4:152326137-152326137
49 HRAS ; LRRC56 NM_005343.4(HRAS): c.38G> C (p.Gly13Ala) single nucleotide variant Likely pathogenic rs104894226 11:534285-534285 11:534285-534285
50 HRAS ; LRRC56 NM_005343.4(HRAS): c.181C> G (p.Gln61Glu) single nucleotide variant Likely pathogenic rs28933406 11:533875-533875 11:533875-533875

Copy number variations for Leukemia, Chronic Lymphocytic from CNVD:

7 (show top 50) (show all 1219)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 14042 1 103366560 104230405 Loss Chronic lymphocytic leukemia
2 14895 1 110954839 111582296 Loss Chronic lymphocytic leukemia
3 14947 1 111421057 111642223 Loss Chronic lymphocytic leukemia
4 15456 1 115719205 117399077 Loss Chronic lymphocytic leukemia
5 17206 1 141510591 145121245 Deletion Chronic lymphocytic leukemia
6 17207 1 141510591 145121245 Loss Chronic lymphocytic leukemia
7 18527 1 146265358 148164994 Gain Chronic lymphocytic leukemia
8 19758 1 151208615 155645185 Gain Chronic lymphocytic leukemia
9 20025 1 152611898 157344161 Loss Chronic lymphocytic leukemia
10 21378 1 158336749 159355008 Loss Chronic lymphocytic leukemia
11 21384 1 158391645 159433573 Loss Chronic lymphocytic leukemia
12 21385 1 158391645 189498990 Loss Chronic lymphocytic leukemia
13 23023 1 170758115 170759115 Loss Chronic lymphocytic leukemia
14 23030 1 170822660 170823660 Gain Chronic lymphocytic leukemia
15 23626 1 172107770 172108770 Gain Chronic lymphocytic leukemia
16 24171 1 176708253 177307399 Gain Chronic lymphocytic leukemia
17 25274 1 186459864 186720923 Loss Chronic lymphocytic leukemia
18 25359 1 187890295 188217703 Loss Chronic lymphocytic leukemia
19 25435 1 189143434 189363313 Gain Chronic lymphocytic leukemia
20 25473 1 189804292 192389810 Gain Chronic lymphocytic leukemia
21 25685 1 193314169 193528753 Gain Chronic lymphocytic leukemia
22 26789 1 202768030 203457313 Loss Chronic lymphocytic leukemia
23 26818 1 203067017 205298659 Loss Chronic lymphocytic leukemia
24 26975 1 204424298 206588789 Loss Chronic lymphocytic leukemia
25 28076 1 218313329 220732423 Loss Chronic lymphocytic leukemia
26 28130 1 218942571 219164038 Loss Chronic lymphocytic leukemia
27 28133 1 218959043 244561923 Loss Chronic lymphocytic leukemia
28 28265 1 220678511 222112407 Gain Chronic lymphocytic leukemia
29 28321 1 221304071 221582122 Gain Chronic lymphocytic leukemia
30 28577 1 223594083 225234079 Loss Chronic lymphocytic leukemia
31 28643 1 224353010 225571533 Loss Chronic lymphocytic leukemia
32 28702 1 224857883 233411748 Loss Chronic lymphocytic leukemia
33 29066 1 227299711 227518155 Loss Chronic lymphocytic leukemia
34 29113 1 227696842 233631743 Loss Chronic lymphocytic leukemia
35 29265 1 229664393 229947546 Gain Chronic lymphocytic leukemia
36 29501 1 232707626 233302391 Loss Chronic lymphocytic leukemia
37 31053 1 24943712 26054939 Loss Chronic lymphocytic leukemia
38 31193 1 25985121 29490451 Deletion Chronic lymphocytic leukemia
39 31425 1 27504484 28494376 Loss Chronic lymphocytic leukemia
40 32443 1 36783544 38823237 Loss Chronic lymphocytic leukemia
41 33495 1 45606989 46307302 Gain Chronic lymphocytic leukemia
42 34016 1 51545765 53346467 Loss Chronic lymphocytic leukemia
43 34255 1 54029769 55100800 Loss Chronic lymphocytic leukemia
44 34911 1 57712092 58034742 Gain Chronic lymphocytic leukemia
45 35379 1 62697088 63142732 Loss Chronic lymphocytic leukemia
46 35406 1 63335974 63596958 Gain Chronic lymphocytic leukemia
47 35407 1 63335974 63641668 Gain Chronic lymphocytic leukemia
48 36497 1 76364563 76710672 Loss Chronic lymphocytic leukemia
49 36890 1 82341866 82576806 Loss Chronic lymphocytic leukemia
50 36895 1 82581235 82812961 Loss Chronic lymphocytic leukemia
Sources

Expression for Leukemia, Chronic Lymphocytic

About this section
Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic.
Sources

Pathways for Leukemia, Chronic Lymphocytic

About this section

Pathways related to Leukemia, Chronic Lymphocytic according to GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.43 TP53 PTPN11 NRAS KRAS IGHG1 HRAS
2
PI3K-Akt signaling pathway 37
Show member pathways
 13.06 TP53 NRAS KRAS HRAS CCND1 ATM
3
Human cytomegalovirus infection 37
Show member pathways
 13.03 TP53 NRAS KRAS HRAS CCND1 ATM
4
CCR5 Pathway in Macrophages 64
Show member pathways
 12.93 NRAS KRAS HRAS CCND1 BRAF
5
Pathways in cancer 37
12.91 TP53 NRAS KRAS HRAS CCND1 BRAF
6
Endometrial cancer 37
Show member pathways
 12.91 TP53 PTPN11 NRAS KRAS HRAS CCND1
7
Apoptosis Modulation and Signaling 1
Show member pathways
 12.87 TP53 NRAS KRAS HRAS ATM
8
Common Cytokine Receptor Gamma-Chain Family Signaling Pathways 65
Show member pathways
 12.84 PTPN11 KRAS HRAS CCND1 BRAF
9
MAPK signaling pathway 37 1
12.83 TP53 NRAS KRAS HRAS BRAF
10
Gastric cancer 37
Show member pathways
 12.83 TP53 NRAS KRAS HRAS CCND1 BRAF
11
Ras signaling pathway 37
Show member pathways
 12.8 PTPN11 NRAS KRAS HRAS BRAF
12
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.79 TP53 PTPN11 NRAS KRAS HRAS
13
Development HGF signaling pathway 22
Show member pathways
 12.78 TP53 PTPN11 NRAS KRAS HRAS BRAF
14
4-1BB Pathway 64
Show member pathways
 12.75 TP53 NRAS KRAS HRAS BRAF
15
Glioma 37
Show member pathways
 12.72 TP53 NRAS KRAS HRAS CCND1 BRAF
16
Immune response IL-23 signaling pathway 22
Show member pathways
 12.67 TP53 PTPN11 NRAS KRAS HRAS
17
Negative regulation of FGFR1 signaling 66
Show member pathways
 12.65 PTPN11 NRAS KRAS HRAS BRAF
18
T cell receptor signaling pathway 37
Show member pathways
 12.61 PTPN11 NRAS KRAS HRAS
19
mTOR signaling pathway (KEGG) 37
Show member pathways
 12.58 TP53 NRAS KRAS HRAS BRAF
20
Prolactin Signaling Pathway 1 37
Show member pathways
 12.56 PTPN11 NRAS KRAS HRAS CCND1
21
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.55 PTPN11 NRAS KRAS IGHG1 HRAS BRAF
22
MET promotes cell motility 66
Show member pathways
 12.53 PTPN11 NRAS KRAS HRAS
23
ErbB signaling pathway 37 1
Show member pathways
 12.53 TP53 PTPN11 NRAS KRAS HRAS CCND1
24
Apoptosis Pathway 71
Show member pathways
 12.51 TP53 NRAS KRAS HRAS ATM
25
Development FGFR signaling pathway 22
Show member pathways
 12.49 PTPN11 NRAS KRAS HRAS
26
RANK Signaling in Osteoclasts 64
Show member pathways
 12.48 NRAS KRAS HRAS BRAF
27
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.48 PTPN11 NRAS KRAS HRAS CCND1
28
Development IGF-1 receptor signaling 22
Show member pathways
 12.47 TP53 PTPN11 IGHG1 HRAS CCND1
29
B cell receptor signaling pathway (KEGG) 1
Show member pathways
 12.47 PTPN11 NRAS KRAS HRAS BRAF
30
Phospholipase D signaling pathway 37
Show member pathways
 12.46 PTPN11 NRAS KRAS HRAS
31
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.46 PTPN11 KRAS HRAS BRAF
32
DNA Damage Response 1
Show member pathways
 12.45 TP53 MIR16-1 MIR106B CCND1 ATM
33
CNTF Signaling 64
Show member pathways
 12.4 NRAS KRAS HRAS BRAF
34
B Cell Receptor Signaling Pathway (sino) 67
Show member pathways
 12.39 PTPN11 NRAS KRAS HRAS
35
Human T-cell leukemia virus 1 infection 37
12.38 TP53 NRAS KRAS HRAS CCND1 ATM
36
Paradoxical activation of RAF signaling by kinase inactive BRAF 66
Show member pathways
 12.36 NRAS KRAS HRAS BRAF
37
Viral carcinogenesis 37
12.36 TP53 NRAS KRAS HRAS CCND1
38
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.34 TP53 PTPN11 POT1 KRAS ATM
39
Signaling by FGFR2 66
Show member pathways
 12.34 PTPN11 NRAS KRAS HRAS BRAF
40
Axon guidance 37
12.31 PTPN11 NRAS KRAS HRAS
41
Cell surface interactions at the vascular wall 66
Show member pathways
 12.3 PTPN11 NRAS KRAS HRAS
42
C-type lectin receptor signaling pathway 37
Show member pathways
 12.29 PTPN11 NRAS KRAS HRAS
43
Long-term potentiation 37
Show member pathways
 12.27 NRAS KRAS HRAS BRAF
44
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 37
Show member pathways
 12.26 NRAS KRAS HRAS CCND1
45
Colorectal Cancer Metastasis 64
12.26 TP53 KRAS CCND1 BRAF
46
EGF/EGFR Signaling Pathway 1
12.26 PTPN11 KRAS HRAS BRAF
47
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 12.24 TP53 NRAS KRAS HRAS CCND1 BRAF
48
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.24 TP53 PTPN11 NRAS KRAS HRAS BRAF
49
mTOR Pathway 71
Show member pathways
 12.22 TP53 NRAS KRAS HRAS BRAF
50
Longevity regulating pathway 37
Show member pathways
 12.21 TP53 NRAS KRAS HRAS
Sources

GO Terms for Leukemia, Chronic Lymphocytic

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Cellular components related to Leukemia, Chronic Lymphocytic according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 MIR29A MIR181A2 MIR16-1 MIR15A MIR143 MIR107

Biological processes related to Leukemia, Chronic Lymphocytic according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.96 TP53 MIR29A MIR16-1 MIR15A HRAS
2 positive regulation of cell migration GO:0030335 9.88 MIR29A MIR181A2 HRAS ATM
3 positive regulation of apoptotic process GO:0043065 9.88 TP53 MIR29A MIR16-1 MIR15A ATM
4 MAPK cascade GO:0000165 9.87 NRAS KRAS HRAS BRAF
5 cytokine-mediated signaling pathway GO:0019221 9.8 TP53 PTPN11 KRAS IGHG1 CCND1
6 positive regulation of gene expression GO:0010628 9.8 TP53 MIR34A MIR29A KRAS HRAS BRAF
7 gene silencing by miRNA GO:0035195 9.76 MIR34A MIR29A MIR181A2 MIR16-1 MIR15A MIR143
8 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.71 NRAS KRAS HRAS
9 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.67 MIR29A MIR16-1 MIR15A
10 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.63 TP53 MIR16-1 MIR15A
11 Ras protein signal transduction GO:0007265 9.62 TP53 NRAS KRAS HRAS
12 negative regulation of glucose import GO:0046325 9.61 MIR143 MIR107
13 positive regulation of connective tissue replacement GO:1905205 9.6