MCID: LKM050
MIFTS: 17

Leukemia, Chronic Lymphocytic 1

Categories: Immune diseases, Cancer diseases, Rare diseases, Blood diseases

Aliases & Classifications for Leukemia, Chronic Lymphocytic 1

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic 1:

Name: Leukemia, Chronic Lymphocytic 1 57 29
Leukemia, Chronic Lymphocytic, Susceptibility to, 1 57 13
Clls1 57

Classifications:



External Ids:

OMIM 57 609630

Summaries for Leukemia, Chronic Lymphocytic 1

MalaCards based summary : Leukemia, Chronic Lymphocytic 1, also known as leukemia, chronic lymphocytic, susceptibility to, 1, is related to leukemia, chronic lymphocytic. An important gene associated with Leukemia, Chronic Lymphocytic 1 is FGF16 (Fibroblast Growth Factor 16). The drugs Fludarabine and Vidarabine have been mentioned in the context of this disorder. Affiliated tissues include b cells.

Description from OMIM: 609630

Related Diseases for Leukemia, Chronic Lymphocytic 1

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 11.1

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic 1

Clinical features from OMIM:

609630

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic 1

Drugs for Leukemia, Chronic Lymphocytic 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
2
Vidarabine Approved, Investigational Phase 3 24356-66-9 32326 21704
3
Chlorambucil Approved Phase 3 305-03-3 2708
4
Obinutuzumab Approved, Investigational Phase 3 949142-50-1
5
rituximab Approved Phase 3 174722-31-7 10201696
6 Anti-Infective Agents Phase 3
7 Antimetabolites Phase 3
8 Antimetabolites, Antineoplastic Phase 3
9 Antiviral Agents Phase 3
10 Immunosuppressive Agents Phase 3
11 Alkylating Agents Phase 3
12 Antineoplastic Agents, Alkylating Phase 3
13 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fludarabine or Observation in Treating Patients With Stage 0, Stage I, or Stage II Chronic Lymphocytic Leukemia Completed NCT00262782 Phase 3 Fludarabine
2 CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2) Completed NCT02053610 Phase 3 obinutuzumab;rituximab;chlorambucil
3 CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b) Completed NCT01998880 Phase 3 obinutuzumab;rituximab;chlorambucil
4 Prospective Collection of Biological Data of Prognostic Relevance in Patients With B-Cell Chronic Lymphocytic Leukemia Unknown status NCT00917540

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic 1

Genetic Tests for Leukemia, Chronic Lymphocytic 1

Genetic tests related to Leukemia, Chronic Lymphocytic 1:

# Genetic test Affiliating Genes
1 Leukemia, Chronic Lymphocytic 1 29 FGF16

Anatomical Context for Leukemia, Chronic Lymphocytic 1

MalaCards organs/tissues related to Leukemia, Chronic Lymphocytic 1:

41
B Cells

Publications for Leukemia, Chronic Lymphocytic 1

Variations for Leukemia, Chronic Lymphocytic 1

Expression for Leukemia, Chronic Lymphocytic 1

Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic 1.

Pathways for Leukemia, Chronic Lymphocytic 1

GO Terms for Leukemia, Chronic Lymphocytic 1

Sources for Leukemia, Chronic Lymphocytic 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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