MCID: LKM051
MIFTS: 17

Leukemia, Chronic Lymphocytic 3

Categories: Immune diseases, Cancer diseases, Rare diseases, Blood diseases

Aliases & Classifications for Leukemia, Chronic Lymphocytic 3

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic 3:

Name: Leukemia, Chronic Lymphocytic 3 57 29
Leukemia, Chronic Lymphocytic, Susceptibility to, 3 57 13
Clls3 57

Classifications:



External Ids:

OMIM 57 612557

Summaries for Leukemia, Chronic Lymphocytic 3

MalaCards based summary : Leukemia, Chronic Lymphocytic 3, also known as leukemia, chronic lymphocytic, susceptibility to, 3, is related to leukemia, chronic lymphocytic. An important gene associated with Leukemia, Chronic Lymphocytic 3 is CLLS3 (Leukemia, Chronic Lymphocytic, Susceptibility To, 3). The drugs Chlorambucil and Cyclophosphamide have been mentioned in the context of this disorder.

Description from OMIM: 612557

Related Diseases for Leukemia, Chronic Lymphocytic 3

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 11.1

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic 3

Clinical features from OMIM:

612557

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic 3

Drugs for Leukemia, Chronic Lymphocytic 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorambucil Approved Phase 3 305-03-3 2708
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
3
Fludarabine Approved Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
4 Alkylating Agents Phase 3,Phase 2,Phase 1
5 Antimetabolites Phase 3,Phase 2,Phase 1
6 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
7 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
8 Antirheumatic Agents Phase 3,Phase 2,Phase 1
9 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
10
alemtuzumab Approved, Investigational Phase 2,Phase 1 216503-57-0
11
Carmustine Approved, Investigational Phase 2 154-93-8 2578
12
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
13
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
14
Etoposide Approved Phase 2 33419-42-0 36462
15
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
16
Melphalan Approved Phase 2 148-82-3 4053 460612
17
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
18
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
19
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
20
Mycophenolate mofetil Approved, Investigational Phase 1, Phase 2 128794-94-5 5281078
21
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
22
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
23
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 32326 21704
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
25
leucovorin Approved, Nutraceutical Phase 1, Phase 2 58-05-9 143 6006
26 Antiemetics Phase 2
27 Anti-Infective Agents Phase 2,Phase 1
28 Anti-Inflammatory Agents Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Antineoplastic Agents, Phytogenic Phase 2
31 Antiviral Agents Phase 2,Phase 1
32 Autonomic Agents Phase 2
33 BB 1101 Phase 2
34 Dexamethasone acetate Phase 2 1177-87-3
35 Etoposide phosphate Phase 2
36 Gastrointestinal Agents Phase 2
37 glucocorticoids Phase 2
38 Hormone Antagonists Phase 2
39 Hormones Phase 2
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
41 Peripheral Nervous System Agents Phase 2
42 Topoisomerase Inhibitors Phase 2
43 Anti-Bacterial Agents Phase 1, Phase 2
44 Antibiotics, Antitubercular Phase 1, Phase 2
45 Antifungal Agents Phase 1, Phase 2
46 Antilymphocyte Serum Phase 1, Phase 2
47 Antitubercular Agents Phase 1, Phase 2
48 Calcineurin Inhibitors Phase 1, Phase 2
49 Cyclosporins Phase 1, Phase 2
50 Dermatologic Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia Unknown status NCT00017108 Phase 3 chlorambucil;cyclophosphamide;fludarabine phosphate
2 Combination Chemotherapy, Total-Body Irradiation, and Alemtuzumab in Treating Patients Undergoing an Autologous Stem Cell Transplant for Stage I, Stage II, Stage III, or Stage IV Chronic Lymphocytic Leukemia Completed NCT00276809 Phase 2 carmustine;cyclophosphamide;cytarabine;dexamethasone;etoposide;fludarabine phosphate;melphalan
3 Cyclophosphamide and Total Body Irradiation in Treating Patients Who Are Undergoing an Autologous Peripheral Stem Cell Transplant For Chronic Lymphocytic Leukemia Completed NCT00275015 Phase 2 carmustine;cyclophosphamide;cytarabine;dexamethasone;etoposide;fludarabine phosphate;melphalan
4 Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia Completed NCT00281983 Phase 1, Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;methotrexate;mycophenolate mofetil

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic 3

Genetic Tests for Leukemia, Chronic Lymphocytic 3

Genetic tests related to Leukemia, Chronic Lymphocytic 3:

# Genetic test Affiliating Genes
1 Leukemia, Chronic Lymphocytic 3 29

Anatomical Context for Leukemia, Chronic Lymphocytic 3

Publications for Leukemia, Chronic Lymphocytic 3

Variations for Leukemia, Chronic Lymphocytic 3

Expression for Leukemia, Chronic Lymphocytic 3

Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic 3.

Pathways for Leukemia, Chronic Lymphocytic 3

GO Terms for Leukemia, Chronic Lymphocytic 3

Sources for Leukemia, Chronic Lymphocytic 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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