MCID: LKM051
MIFTS: 18

Leukemia, Chronic Lymphocytic 3

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Leukemia, Chronic Lymphocytic 3

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic 3:

Name: Leukemia, Chronic Lymphocytic 3 58 30
Leukemia, Chronic Lymphocytic, Susceptibility to, 3 58 13
Clls3 58

Classifications:



External Ids:

OMIM 58 612557

Summaries for Leukemia, Chronic Lymphocytic 3

MalaCards based summary : Leukemia, Chronic Lymphocytic 3, also known as leukemia, chronic lymphocytic, susceptibility to, 3, is related to leukemia, chronic lymphocytic. An important gene associated with Leukemia, Chronic Lymphocytic 3 is CLLS3 (Leukemia, Chronic Lymphocytic, Susceptibility To, 3). The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone.

Description from OMIM: 612557

Related Diseases for Leukemia, Chronic Lymphocytic 3

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic 3 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 11.3

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic 3

Clinical features from OMIM:

612557

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic 3

Drugs for Leukemia, Chronic Lymphocytic 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 3,Phase 2,Phase 1 75607-67-9, 21679-14-1 30751
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
3
Chlorambucil Approved Phase 3 305-03-3 2708
4 Immunologic Factors Phase 3,Phase 2,Phase 1
5 Antimetabolites Phase 3,Phase 2,Phase 1
6 Antirheumatic Agents Phase 3,Phase 2,Phase 1
7 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
8 Alkylating Agents Phase 3,Phase 2,Phase 1
9 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
10 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
11
Melphalan Approved Phase 2 148-82-3 460612 4053
12
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
13
Carmustine Approved, Investigational Phase 2 154-93-8 2578
14
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
15
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
16
alemtuzumab Approved, Investigational Phase 2,Phase 1 216503-57-0
17
Etoposide Approved Phase 2 33419-42-0 36462
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
19
Vidarabine Approved, Investigational Phase 1, Phase 2 24356-66-9 21704 32326
20
leucovorin Approved Phase 1, Phase 2 58-05-9 143 6006
21
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
22
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
23
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
24
Methotrexate Approved Phase 1, Phase 2 1959-05-2, 59-05-2 126941
25
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
27 glucocorticoids Phase 2
28 Anti-Inflammatory Agents Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Antiviral Agents Phase 2,Phase 1
31 Antineoplastic Agents, Immunological Phase 2,Phase 1
32 Hormones Phase 2
33 BB 1101 Phase 2
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
35 Hormone Antagonists Phase 2
36 Gastrointestinal Agents Phase 2
37 Antineoplastic Agents, Phytogenic Phase 2
38 Anti-Infective Agents Phase 2,Phase 1
39 Antiemetics Phase 2
40 Peripheral Nervous System Agents Phase 2
41 Etoposide phosphate Phase 2
42 Autonomic Agents Phase 2
43 Topoisomerase Inhibitors Phase 2
44 Nucleic Acid Synthesis Inhibitors Phase 1, Phase 2
45 Folate Phase 1, Phase 2
46 Antibiotics, Antitubercular Phase 1, Phase 2
47 Vitamin B9 Phase 1, Phase 2
48 Vitamin B Complex Phase 1, Phase 2
49 Dermatologic Agents Phase 1, Phase 2
50 Antitubercular Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia Unknown status NCT00017108 Phase 3 chlorambucil;cyclophosphamide;fludarabine phosphate
2 Combination Chemotherapy, Total-Body Irradiation, and Alemtuzumab in Treating Patients Undergoing an Autologous Stem Cell Transplant for Stage I, Stage II, Stage III, or Stage IV Chronic Lymphocytic Leukemia Completed NCT00276809 Phase 2 carmustine;cyclophosphamide;cytarabine;dexamethasone;etoposide;fludarabine phosphate;melphalan
3 Cyclophosphamide and Total Body Irradiation in Treating Patients Who Are Undergoing an Autologous Peripheral Stem Cell Transplant For Chronic Lymphocytic Leukemia Completed NCT00275015 Phase 2 carmustine;cyclophosphamide;cytarabine;dexamethasone;etoposide;fludarabine phosphate;melphalan
4 Fludarabine and Cyclophosphamide in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Lymphocytic Leukemia or Waldenstrom's Macroglobulinemia Completed NCT00281983 Phase 1, Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;methotrexate;mycophenolate mofetil

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic 3

Genetic Tests for Leukemia, Chronic Lymphocytic 3

Genetic tests related to Leukemia, Chronic Lymphocytic 3:

# Genetic test Affiliating Genes
1 Leukemia, Chronic Lymphocytic 3 30

Anatomical Context for Leukemia, Chronic Lymphocytic 3

MalaCards organs/tissues related to Leukemia, Chronic Lymphocytic 3:

42
Bone

Publications for Leukemia, Chronic Lymphocytic 3

Variations for Leukemia, Chronic Lymphocytic 3

Expression for Leukemia, Chronic Lymphocytic 3

Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic 3.

Pathways for Leukemia, Chronic Lymphocytic 3

GO Terms for Leukemia, Chronic Lymphocytic 3

Sources for Leukemia, Chronic Lymphocytic 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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