MCID: LKM052
MIFTS: 16

Leukemia, Chronic Lymphocytic 5

Categories: Immune diseases, Cancer diseases, Rare diseases, Blood diseases

Aliases & Classifications for Leukemia, Chronic Lymphocytic 5

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic 5:

Name: Leukemia, Chronic Lymphocytic 5 57
Leukemia, Chronic Lymphocytic, Susceptibility to, 5 57 29
Leukemia, Chronic Lymphocytic Susceptibility to, 5 57 13
Clls5 57

Classifications:



External Ids:

OMIM 57 612559

Summaries for Leukemia, Chronic Lymphocytic 5

MalaCards based summary : Leukemia, Chronic Lymphocytic 5, also known as leukemia, chronic lymphocytic, susceptibility to, 5, is related to leukemia, chronic lymphocytic. An important gene associated with Leukemia, Chronic Lymphocytic 5 is CLLS5 (Leukemia, Chronic Lymphocytic Susceptiblity To, 5). The drugs Chlorambucil and Fludarabine have been mentioned in the context of this disorder.

Description from OMIM: 612559

Related Diseases for Leukemia, Chronic Lymphocytic 5

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic 5 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 11.1

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic 5

Clinical features from OMIM:

612559

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic 5

Drugs for Leukemia, Chronic Lymphocytic 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorambucil Approved Phase 3 305-03-3 2708
2
Fludarabine Approved Phase 3,Phase 1,Phase 2 21679-14-1, 75607-67-9 30751
3
Vidarabine Approved, Investigational Phase 3,Phase 1,Phase 2 24356-66-9 32326 21704
4 Alkylating Agents Phase 3
5 Anti-Infective Agents Phase 3,Phase 1,Phase 2
6 Antimetabolites Phase 3,Phase 1,Phase 2
7 Antimetabolites, Antineoplastic Phase 3,Phase 1,Phase 2
8 Antineoplastic Agents, Alkylating Phase 3
9 Antiviral Agents Phase 3,Phase 1,Phase 2
10 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
11
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
12
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
13 Angiogenesis Inhibitors Phase 1, Phase 2
14 Angiogenesis Modulating Agents Phase 1, Phase 2
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Antirheumatic Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia Completed NCT00262795 Phase 3 Fludarabine;Chlorambucil
2 Lenalidomide Dose Escalation Combined With Rituximab/Fludarabine in Untreated CLL Completed NCT00738829 Phase 1, Phase 2 Lenalidomide;Fludarabine

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic 5

Genetic Tests for Leukemia, Chronic Lymphocytic 5

Genetic tests related to Leukemia, Chronic Lymphocytic 5:

# Genetic test Affiliating Genes
1 Leukemia, Chronic Lymphocytic, Susceptibility to, 5 29

Anatomical Context for Leukemia, Chronic Lymphocytic 5

Publications for Leukemia, Chronic Lymphocytic 5

Variations for Leukemia, Chronic Lymphocytic 5

Expression for Leukemia, Chronic Lymphocytic 5

Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic 5.

Pathways for Leukemia, Chronic Lymphocytic 5

GO Terms for Leukemia, Chronic Lymphocytic 5

Sources for Leukemia, Chronic Lymphocytic 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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