Leukemia, Chronic Lymphocytic 5 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Leukemia, Chronic Lymphocytic 5

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic 5:

Name: Leukemia, Chronic Lymphocytic 5 ⁵⁷

Leukemia, Chronic Lymphocytic, Susceptibility to, 5 ⁵⁷ ²⁹

Leukemia, Chronic Lymphocytic Susceptibility to, 5 ⁵⁷ ¹³

Clls5 ⁵⁷

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 612559

Sources

Summaries for Leukemia, Chronic Lymphocytic 5

MalaCards based summary : Leukemia, Chronic Lymphocytic 5, also known as leukemia, chronic lymphocytic, susceptibility to, 5, is related to leukemia, chronic lymphocytic. An important gene associated with Leukemia, Chronic Lymphocytic 5 is CLLS5 (Leukemia, Chronic Lymphocytic Susceptiblity To, 5). The drugs Chlorambucil and Fludarabine have been mentioned in the context of this disorder.

Description from OMIM: 612559

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Related Diseases for Leukemia, Chronic Lymphocytic 5

Diseases in the Acute Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2	Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1	Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4	Leukemia, Chronic Lymphocytic 5
Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic 5 via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	leukemia, chronic lymphocytic	11.1

Sources

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic 5

Clinical features from OMIM:

612559

Sources

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic 5

Drugs for Leukemia, Chronic Lymphocytic 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Chlorambucil

Approved

Phase 3

305-03-3

2708

Synonyms:

23125_FLUKA

305-03-3

4-(Bis(2-chloroethyl)amino)benzenebutanoic acid

4-(P-Bis(b-chloroethyl)aminophenyl)butyrate

4-(P-Bis(b-chloroethyl)aminophenyl)butyric acid

4-(P-Bis(beta-chloroethyl)aminophenyl)butyrate

4-(P-Bis(beta-chloroethyl)aminophenyl)butyric acid

4-(P-Bis(β-chloroethyl)aminophenyl)butyrate

4-(p-bis(β-chloroethyl)aminophenyl)butyric acid

4-(P-Bis(β-chloroethyl)aminophenyl)butyric acid

4-[P-[Bis(2-chloroethyl)amino]phenyl]butyrate

4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid

4-[P-[Bis(2-chloroethyl)amino]phenyl]butyric acid

AB00051938

AC1L1EAB

AC1Q75DO

AI3-26083

Ambochlorin

Amboclorin

BPBio1_001208

BRD-K29458283-001-05-9

BRN 0999011

BSPBio_001098

BSPBio_001971

C 0253

C0253_SIGMA

C14H19Cl2NO2

CAS-305-03-3

CB 1348

Cb l348

CB1348

CB-1348

CCRIS 126

CHEBI:28830

CHEMBL515

Chlocambucil

Chloorambucol

chlorambucil

CHLORAMBUCIL

Chlorambucil (USP/INN)

Chlorambucil [INN:BAN]

Chlorambucilum

Chlorambucilum [INN-Latin]

Chloraminophen

Chloraminophene

Chlorbutin

Chlorbutine

Chlorbutinum

Chloroambucil

Chlorobutin

Chlorobutine

CID2708

Clorambucile

Clorambucile [DCIT]

Clorambucilo

Clorambucilo [INN-Spanish]

CPD000058372

D00266

D002699

DB00291

DivK1c_000688

Ecloril

EINECS 206-162-0

Elcoril

Elcorin

EU-0100227

FT-0083565

g-[P-Di(2-chloroethyl)aminophenyl]butyrate

g-[P-Di(2-chloroethyl)aminophenyl]butyric acid

gamma-[P-Di(2-chloroethyl)aminophenyl]butyrate

gamma-[P-Di(2-chloroethyl)aminophenyl]butyric acid

glaxo Wellcome brand OF chlorambucil

Glaxo Wellcome Brand of Chlorambucil

GlaxoSmithKline brand OF chlorambucil

GlaxoSmithKline Brand of Chlorambucil

HMS1571G20

HMS1920M15

HMS2090M19

HMS2091A22

HMS502C10

HSDB 3026

IDI1_000688

KBio1_000688

KBio2_000558

KBio2_003126

KBio2_005694

KBio3_001191

KBioGR_000766

KBioSS_000558

Leuk ersan

Leukeran

LEUKERAN (TN)

Leukeran tablets

Leukeran Tablets

Leukersan

Leukoran

Linfolizin

Linfolysin

Lopac0_000227

Lopac-C-0253

LS-1158

Lympholysin

MLS000028443

MLS001076130

MolPort-000-152-694

N,N-Di-(2-chloroethyl)-P-aminophenylbutyric acid

N,N-Di-2-chloroethyl-gamma-P-aminophenylbutyrate

N,N-Di-2-chloroethyl-gamma-P-aminophenylbutyric acid

N,N-Di-2-chloroethyl-g-P-aminophenylbutyrate

N,N-Di-2-chloroethyl-g-P-aminophenylbutyric acid

N,N-Di-2-chloroethyl-γ-P-aminophenylbutyrate

N,N-di-2-chloroethyl-γ-p-aminophenylbutyric acid

N,N-Di-2-chloroethyl-γ-P-aminophenylbutyric acid

NCGC00015199-01

NCGC00015199-02

NCGC00015199-03

NCGC00015199-07

NCGC00015199-14

NCGC00023250-00

NCGC00023250-03

NCGC00023250-04

NCGC00023250-05

NCGC00023250-06

NCGC00023250-07

NCGC00023250-08

NCGC00023250-09

NCGC00023250-10

NCI60_002639

NCI-C03485

NINDS_000688

NSC 3088

NSC3088

NSC-3088

Pepstatin

Phenylbuttersaeure-lost

Phenylbuttersaeure-lost [German]

Phenylbutyrate nitrogen mustard

Phenylbutyric acid nitrogen mustard

Phenylbutyric Acid Nitrogen Mustard

Prestwick0_001079

Prestwick1_001079

Prestwick2_001079

Prestwick3_001079

RCRA waste no. U035

Rcra waste number U035

SAM002564202

SMR000058372

SPBio_000249

SPBio_002999

Spectrum_000118

SPECTRUM1500171

Spectrum2_000065

Spectrum3_000336

Spectrum4_000273

Spectrum5_000677

ST50410766

TL8002353

UNII-18D0SL7309

Wellcome brand OF chlorambucil

Wellcome Brand of Chlorambucil

WLN: QV3R DN2G2G

γ-[P-di(2-chloroethyl)aminophenyl]butyrate

γ-[p-di(2-chloroethyl)aminophenyl]butyric acid

γ-[P-di(2-chloroethyl)aminophenyl]butyric acid

2

Fludarabine

Approved

Phase 3,Phase 1,Phase 2

21679-14-1, 75607-67-9

30751

Synonyms:

(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

21679-14-1

2-F-ara-A

2-F-ARAA

2F-Ara-AMP

2-fluoro ARA-A

2-Fluoro Ara-A

2-Fluoro-9-beta-D-arabinofuranosyladenine

2-Fluoroadenine arabinoside 5'-monophosphate

2-Fluoroadenine arabinoside 5'-monophosphoric acid

2-fluoro-ARA AMP

9 beta-D-Arabinofuranosyl-2-fluoroadenine monophosphate

9-b-Arabinofuranosyl-2-fluoroadenine-5'-phosphate

9-b-Arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate

9-b-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid

9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate

9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid

9-beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine

9-beta-D-Arabinofuranosyl-2-fluoroadenine

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate

9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid

9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro- (9CI)

9-β-arabinofuranosyl-2-fluoroadenine-5'-phosphate

9-β-arabinofuranosyl-2-fluoroadenine-5'-phosphoric acid

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate)

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphoric acid)

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphate

9-β-D-arabinofuranosyl-2-fluoroadenine 5'-monophosphoric acid

AC1LCW8I

AC1Q51CF

Beneflur

C10H12FN5O4

CCRIS 3382

CHEMBL1568

CID657237

CPD000058874

D07966

EINECS 244-525-5

FAMP

FaraA

F-Ara-A

FaraAMP

F-Ara-AMP

Fludara

Fludara, Fludarabine

Fludarabina

Fludarabina [Spanish]

Fludarabine

Fludarabine (INN)

Fludarabine [INN]

Fludarabine 5'-monophosphate

Fludarabine 5'-monophosphoric acid

Fludarabine monophosphate

Fludarabine monophosphoric acid

Fludarabine phosphate

Fludarabinum

Fludarabinum [Latin]

Fludura

fluoro-Ara-AMP

Fluradosa

Fluradosa (TN)

FT-0082766

HSDB 6964

I14-4978

LS-15061

MLS000028687

NSC 118218

NSC 118218H

NSC-118218

S1491_Selleck

SAM002548956

SMR000058874

SQ Fludarabine

UNII-1X9VK9O1SC

UNII-P2K93U8740

ZINC04216238

3

Vidarabine

Approved, Investigational

Phase 3,Phase 1,Phase 2

24356-66-9

32326 21704

Synonyms:

(+)-Cyclaradine

.beta.-Adenosine

.beta.-D-Adenosine

1odi

2-(6-amino-PURIN-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

2-(6-AMINO-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol

2946-52-3

2fqy

2gl0

30143-02-3

3080-29-3

3228-71-5

4005-33-8

46946-45-6

46969-16-8

524-69-6

5536-17-4

58-61-7

9 beta Arabinofuranosyladenine

9 beta D Arabinofuranosyladenine

9-Arabinosyladenine

9-b-D-Arabinofuranosyl-9H-purin-6-amine

9-b-D-Arabinofuranosyladenine

9-beta-Arabinofuranosyladenine

9-beta-D-Arabinofuranosyl-9H-purin-6-amine

9-beta-D-arabinofuranosyl-adenine

9-beta-D-Arabinofuranosyladenine

9-beta-D-Arabinofuranosyl-adenine

9-β-D-arabinofuranosyl-9H-purin-6-amine

9-β-D-arabinofuranosyladenine

A 9251

a, alpha-Ara

a, Ara

a, beta-Ara

A0152

A4036_SIGMA

A4676_SIGMA

A5762_SIGMA

A9251_SIGMA

AC1L18OL

AC1L1U8O

AC1L2IWM

AC1L2SCM

AC1O4WIN

AC1O8PY7

AC1Q1ID3

AC1Q4Y1Z

AC1Q52XU

Adenine arabinoside

Adenine nucleoside

Adenine riboside

Adenine xyloside

adenine-D-ribose

Adenocard

Adenocard (TN)

Adenocard, Adenosine

Adenocor

Adenoscan

Adenoscan (TN)

Adenosin

Adenosin [German]

adenosine

Adenosine (JAN/USP)

Adenosine [USAN:BAN]

Adenosine arabinose

ADENOSINE, U.S.P.

Adenosine-8-14C

Adensoine

Ade-Rib

ADN

AI3-52413

AI3-52821

alpha Ara a

alpha D Arabinofuranosyladenine

alpha-Ara a

alpha-Ara A

alpha-D-Arabinofuranosyladenine

Ambap5536-17-4

AR-1H6029

Ara a

Ara A

Ara-a

Ara-A

ARA-A NSC 247519

Araadenosine

Ara-ATP

Arabinofuranosyladenine

Arabinoside adenine

Arabinoside, adenine

Arabinosyl adenine

Arabinosyladenine

Arabinosyl-adenine

Arasena-A

Armes

Armes (TN)

BB_NC-0565

beta Ara a

beta-Adenosine

beta-Ara a

beta-Ara A

beta-D-Adenosine

Bio1_000437

Bio1_000926

Bio1_001415

bmse000061

Boniton

BPBio1_000898

BRN 0624881

BSPBio_000816

BSPBio_001796

BSPBio_002000

C00212

CAS-5536-17-4

Caswell No. 010B

CCRIS 2557

CCRIS 3383

CHEBI:136932

CHEBI:16335

CHEBI:45327

CHEMBL1090

CHEMBL20247

CHEMBL477

CI 673

CI-673

CID102198

CID191

CID21704

CID60961

CID6420052

CID6713976

CPD000471872

D000241

D00045

D06298

DB00640

DivK1c_000191

EINECS 200-389-9

EINECS 217-911-6

EINECS 226-893-9

EU-0100123

FT-0082881

HMS1570I18

HMS1920A13

HMS1921K05

HMS2090F06

HMS2091G13

HMS2092C16

HMS500J13

HSDB 6514

I01-1121

IDI1_000191

KBio1_000191

KBio2_002418

KBio2_004986

KBio2_007554

KBio3_001296

KBio3_001500

KBioGR_001224

KBioSS_002424

L000094

Lopac0_000123

LS-15059

LS-15085

MEDR-640

MLS000069638

MLS000699527

MLS001066352

MLS001333133

MLS001333134

MLS002153227

MLS002153992

MolPort-001-785-903

MolPort-001-838-229

MolPort-003-666-308

Monarch brand OF vidarabine

Myocol

NCGC00016656-01

NCGC00023673-03

NCGC00023673-04

NCGC00023673-05

NCGC00023673-06

NCGC00023673-07

NCGC00094579-01

NCGC00094579-02

NCGC00094579-03

NCGC00094579-04

NCGC00178869-01

NCGC00179417-01

nchembio.143-comp9

nchembio.186-comp109

nchembio.64-comp4

nchembio706-5

NCI60_003823

NCI60_037192

NCIOpen2_003303

NCIOpen2_005376

NINDS_000191

NSC 247519

NSC 404241

NSC 627048

NSC 7359

NSC 7652

NSC247519

NSC404241

NSC-404241

NSC627048

NSC70422

NSC7359

NSC7652

NSC80832

NSC87676

NSC91041

Nucleocardyl

Pallacor

Parke davis brand OF vidarabine

PDSP1_001036

PDSP2_001020

Polyadenosine

Polyriboadenosine

Prestwick_983

Prestwick0_000768

Prestwick1_000768

Prestwick2_000768

Prestwick3_000768

RAB

S1647_Selleck

S1784_Selleck

SAM002564191

Sandesin

SMP1_000312

SMR000058216

SMR000225041

SMR000471872

SMR001233326

SPBio_001194

SPBio_001491

SPBio_002755

Spectrum_001894

SPECTRUM1500107

SPECTRUM1500609

Spectrum2_001257

Spectrum2_001336

Spectrum3_000288

Spectrum3_000580

Spectrum4_000782

Spectrum5_001429

Spongoadenosine

SR 96225

SR-96225

STK361815

SUN-Y4001

TL8003749

UNII-3XQD2MEW34

UNII-K72T3FS567

USAF CB-10

V0098

Vidarabin

Vidarabina

Vidarabina [DCIT]

Vidarabine

Vidarabine (JAN)

Vidarabine anhydrous

Vidarabinum

Vira a

Vira ATM

Vira-a

ViraA

Vira-A

Vira-A, Vidarabine

VIRDARABINE

XA

Xylosyl A

Xylosyladenine

ZINC00970363

ZINC02169830

4

Alkylating Agents

Phase 3

5

Anti-Infective Agents

Phase 3,Phase 1,Phase 2

6

Antimetabolites

Phase 3,Phase 1,Phase 2

7

Antimetabolites, Antineoplastic

Phase 3,Phase 1,Phase 2

8

Antineoplastic Agents, Alkylating

Phase 3

9

Antiviral Agents

Phase 3,Phase 1,Phase 2

10

Immunosuppressive Agents

Phase 3,Phase 1,Phase 2

11

Lenalidomide

Approved

Phase 1, Phase 2

191732-72-6

216326

Synonyms:

191732-72-6

1-oxo-2-(2,6-Dioxopiperidin-3-yl)-4-aminoisoindoline

3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

3-(4-amino-1-Oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

3-(7-Amino-3-oxo-1H-isoindol-2-yl)-piperidine-2,6-dione

346670-73-3

443912-14-9

AC1L50II

AC-914

AKOS005146276

ALBB-015321

Bio-0168

C467567

CC 5013

CC5013

CC-5013

CC-5013, Revlimid, Lenalidomide

CDC 501

CDC-501

CDC-5013

Celgene brand of lenalidomide

Celgene brand OF lenalidomide

CHEMBL848

CID216326

D04687

DB00480

EC-000.2340

ENMD-0997

I06-0831

IMid-1

IMID-1

IMiD3

IMiD3 cpd

IMiD3 CPD

IMID-5013

lenalidomide

Lenalidomide

Lenalidomide (USAN/INN)

Lenalidomide [USAN]

LS-184040

MolPort-003-848-370

NCGC00167491-01

NSC747972

Revamid

Revimid

Revlimid

Revlimid (Celgene)

Revlimid (TN)

S1029_Selleck

STK639603

Thalidomide analog CC-5013

UNII-F0P408N6V4

12

rituximab

Approved

Phase 1, Phase 2

174722-31-7

10201696

13

Angiogenesis Inhibitors

Phase 1, Phase 2

14

Angiogenesis Modulating Agents

Phase 1, Phase 2

15

Anti-Bacterial Agents

Phase 1, Phase 2

16

Antirheumatic Agents

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia	Completed	NCT00262795	Phase 3	Fludarabine;Chlorambucil
2	Lenalidomide Dose Escalation Combined With Rituximab/Fludarabine in Untreated CLL	Completed	NCT00738829	Phase 1, Phase 2	Lenalidomide;Fludarabine

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic 5

Sources

Genetic Tests for Leukemia, Chronic Lymphocytic 5

Genetic tests related to Leukemia, Chronic Lymphocytic 5:

#	Genetic test	Affiliating Genes
1	Leukemia, Chronic Lymphocytic, Susceptibility to, 5 ²⁹

Sources

Anatomical Context for Leukemia, Chronic Lymphocytic 5

Sources

Publications for Leukemia, Chronic Lymphocytic 5

Sources

Genes for Leukemia, Chronic Lymphocytic 5

Genes related to Leukemia, Chronic Lymphocytic 5 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CLLS5	Leukemia, Chronic Lymphocytic Susceptiblity To, 5	Genetic Locus	50	Susceptibility factor ⁵⁷

Sources

Variations for Leukemia, Chronic Lymphocytic 5

Sources

Expression for Leukemia, Chronic Lymphocytic 5

Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic 5.

Sources

Pathways for Leukemia, Chronic Lymphocytic 5

Sources

GO Terms for Leukemia, Chronic Lymphocytic 5

Sources

Sources for Leukemia, Chronic Lymphocytic 5

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia