MCID: LKM052
MIFTS: 17

Leukemia, Chronic Lymphocytic 5

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Leukemia, Chronic Lymphocytic 5

MalaCards integrated aliases for Leukemia, Chronic Lymphocytic 5:

Name: Leukemia, Chronic Lymphocytic 5 58
Leukemia, Chronic Lymphocytic, Susceptibility to, 5 58 30
Leukemia, Chronic Lymphocytic Susceptibility to, 5 58 13
Clls5 58

Classifications:



External Ids:

OMIM 58 612559

Summaries for Leukemia, Chronic Lymphocytic 5

MalaCards based summary : Leukemia, Chronic Lymphocytic 5, also known as leukemia, chronic lymphocytic, susceptibility to, 5, is related to leukemia, chronic lymphocytic. An important gene associated with Leukemia, Chronic Lymphocytic 5 is CLLS5 (Leukemia, Chronic Lymphocytic Susceptiblity To, 5). The drugs Fludarabine and Vidarabine have been mentioned in the context of this disorder. Affiliated tissues include bone.

Description from OMIM: 612559

Related Diseases for Leukemia, Chronic Lymphocytic 5

Diseases in the Lymphocytic Leukemia family:

Leukemia, Chronic Lymphocytic 2 Leukemia, Chronic Lymphocytic
Leukemia, Chronic Lymphocytic 1 Leukemia, Chronic Lymphocytic 3
Leukemia, Chronic Lymphocytic 4 Leukemia, Chronic Lymphocytic 5
Acute Lymphocytic Leukemia Adult Acute Lymphocytic Leukemia

Diseases related to Leukemia, Chronic Lymphocytic 5 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 11.3

Symptoms & Phenotypes for Leukemia, Chronic Lymphocytic 5

Clinical features from OMIM:

612559

Drugs & Therapeutics for Leukemia, Chronic Lymphocytic 5

Drugs for Leukemia, Chronic Lymphocytic 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 3,Phase 1,Phase 2 75607-67-9, 21679-14-1 30751
2
Vidarabine Approved, Investigational Phase 3,Phase 1,Phase 2 24356-66-9 21704 32326
3
Chlorambucil Approved Phase 3 305-03-3 2708
4 Antiviral Agents Phase 3,Phase 1,Phase 2
5 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
6 Alkylating Agents Phase 3
7 Antineoplastic Agents, Alkylating Phase 3
8 Anti-Infective Agents Phase 3,Phase 1,Phase 2
9 Immunologic Factors Phase 3,Phase 1,Phase 2
10 Antimetabolites, Antineoplastic Phase 3,Phase 1,Phase 2
11 Antimetabolites Phase 3,Phase 1,Phase 2
12
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
13
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
14 Angiogenesis Modulating Agents Phase 1, Phase 2
15 Antirheumatic Agents Phase 1, Phase 2
16 Antineoplastic Agents, Immunological Phase 1, Phase 2
17 Angiogenesis Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia Completed NCT00262795 Phase 3 Fludarabine;Chlorambucil
2 Lenalidomide Dose Escalation Combined With Rituximab/Fludarabine in Untreated CLL Completed NCT00738829 Phase 1, Phase 2 Lenalidomide;Fludarabine

Search NIH Clinical Center for Leukemia, Chronic Lymphocytic 5

Genetic Tests for Leukemia, Chronic Lymphocytic 5

Genetic tests related to Leukemia, Chronic Lymphocytic 5:

# Genetic test Affiliating Genes
1 Leukemia, Chronic Lymphocytic, Susceptibility to, 5 30

Anatomical Context for Leukemia, Chronic Lymphocytic 5

MalaCards organs/tissues related to Leukemia, Chronic Lymphocytic 5:

42
Bone

Publications for Leukemia, Chronic Lymphocytic 5

Variations for Leukemia, Chronic Lymphocytic 5

Expression for Leukemia, Chronic Lymphocytic 5

Search GEO for disease gene expression data for Leukemia, Chronic Lymphocytic 5.

Pathways for Leukemia, Chronic Lymphocytic 5

GO Terms for Leukemia, Chronic Lymphocytic 5

Sources for Leukemia, Chronic Lymphocytic 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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