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MCID: LKM005
MIFTS: 34

Leukemia, T-Cell, Chronic

Categories: Blood diseases, Cancer diseases, Immune diseases, Infectious diseases, Rare diseases, Skin diseases
Tissues Related diseases Publications Drugs
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Aliases & Classifications for Leukemia, T-Cell, Chronic

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MalaCards integrated aliases for Leukemia, T-Cell, Chronic:

Name: Leukemia, T-Cell, Chronic 52 71
Chronic T-Cell Leukemia 52
Leukemia, T-Cell 71
T-Cell Leukemia 52

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases Infectious diseases
Anatomical: Skin diseases Blood diseases Immune diseases
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UMLS 71 C0023492 C0023494
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Summaries for Leukemia, T-Cell, Chronic

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MalaCards based summary : Leukemia, T-Cell, Chronic, also known as chronic t-cell leukemia, is related to adult t-cell leukemia and human t-cell leukemia virus type 1. The drugs Zidovudine and Peginterferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone.

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Related Diseases for Leukemia, T-Cell, Chronic

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Diseases in the Adult T-Cell Leukemia family:

Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, T-Cell, Chronic

Diseases related to Leukemia, T-Cell, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 538)
# Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 13.1
2 human t-cell leukemia virus type 1 12.9
3 human t-cell leukemia virus type 2 12.8
4 pediatric t-cell leukemia 12.6
5 human t-cell leukemia virus type 3 12.6
6 t-cell lymphoblastic leukemia/lymphoma 12.3
7 n syndrome 12.0
8 t-cell acute lymphoblastic leukemia 12.0
9 t-cell adult acute lymphocytic leukemia 11.9
10 htlv-1 associated myelopathy/tropical spastic paraparesis 11.9
11 myelopathy, htlv-1-associated 11.8
12 tropical spastic paraparesis 11.8
13 t-cell prolymphocytic leukemia 11.7
14 glut1 deficiency syndrome 1 11.3
15 retrovirus-associated myelopathy 11.3
16 follicular lymphoma 11.2
17 agammaglobulinemia 11.1
18 hepatosplenic t-cell lymphoma 11.1
19 lymphoma 11.1
20 spastic paraparesis 11.0
21 chronic interstitial cystitis 10.9
22 leukemia, acute lymphoblastic 10.8
23 precursor t-cell acute lymphoblastic leukemia 10.8
24 alcoholic hepatitis 10.8
25 human immunodeficiency virus type 1 10.7
26 severe combined immunodeficiency 10.7
27 mycosis fungoides 10.7
28 acquired immunodeficiency syndrome 10.6
29 cutaneous t cell lymphoma 10.6
30 peripheral t-cell lymphoma 10.6
31 b-cell lymphoma 10.6
32 graft-versus-host disease 10.6
33 uveitis 10.5
34 strongyloidiasis 10.5
35 hairy cell leukemia 10.5
36 exanthem 10.5
37 acute leukemia 10.5
38 neutropenia 10.5
39 bone resorption disease 10.5
40 chromosomal triplication 10.5
41 lymphoma, hodgkin, classic 10.4
42 immune deficiency disease 10.4
43 retinoblastoma 10.4
44 anaplastic large cell lymphoma 10.4
45 familial retinoblastoma 10.4
46 hypereosinophilic syndrome 10.4
47 lymphosarcoma 10.4
48 lymphoma, non-hodgkin, familial 10.4
49 stomatitis 10.4
50 cytomegalovirus infection 10.4

Graphical network of the top 20 diseases related to Leukemia, T-Cell, Chronic:



Diseases related to Leukemia, T-Cell, Chronic
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Symptoms & Phenotypes for Leukemia, T-Cell, Chronic

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Drugs & Therapeutics for Leukemia, T-Cell, Chronic

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Drugs for Leukemia, T-Cell, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 329)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 4 30516-87-1 35370
2
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
3
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
4 Interferon alpha-2 Phase 4
5 Interferon-alpha Phase 4
6 Anti-HIV Agents Phase 4
7 interferons Phase 4
8 Reverse Transcriptase Inhibitors Phase 4
9 Anti-Retroviral Agents Phase 4
10 Anticonvulsants Phase 4
11
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
12
Cefepime Approved, Investigational Phase 3 88040-23-7 5479537
13
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
14
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
15
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
16
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
17
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
18 Orange Approved Phase 3
19
Thioguanine Approved Phase 3 154-42-7 2723601
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
21
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
22
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
23
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
24
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
25 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
26
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 38904 498142
27
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
28
Iron Approved, Experimental Phase 3 15438-31-0, 7439-89-6 27284 23925
29
Dalteparin Approved Phase 3 9005-49-6
30
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
31
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
32
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
33
Ofloxacin Approved Phase 3 82419-36-1 4583
34
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
35
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
36
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
37
Caspofungin Approved Phase 3 162808-62-0, 179463-17-3 2826718 468682
38
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
39
Tazobactam Approved Phase 3 89786-04-9 123630
40
Vancomycin Approved Phase 3 1404-90-6 14969 441141
41
Piperacillin Approved Phase 3 66258-76-2 43672
42
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
43
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
44
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
45
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
46
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
47
Melphalan Approved Phase 3 148-82-3 460612 4053
48
leucovorin Approved Phase 3 58-05-9 6006 143
49
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
50
Daunorubicin Approved Phase 3 20830-81-3 30323

Interventional clinical trials:

(show top 50) (show all 379)
# Name Status NCT ID Phase Drugs
1 HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL) Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
2 HTLV Blot 2.4 Post-Market Clinical Study of Neurological Disorders and HTLV Positive Specimens Completed NCT03226119 Phase 4
3 Prospective Study of the Molecular Characteristics of Sensitive and Resistant Disease in Patients With HTLV-I Associated Adult T Cell Leukemia Treated With Zidovudine (AZT) Plus Interferon Alpha-2b Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
4 Multicenter, Double-Blind, Randomized Study to Compare the Safety and Efficacy of Levofloxacin With That of Cefepime in the Treatment of Fever and Neutropenia - Phase IIIB Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
5 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
6 Randomised Study Comparing 6 And 8 Cycles Of Chemotherapy With CHOP ( Cyclophosphamide, Doxorubicin, Vincristine And Prednisone) At 14-Day Intervals (CHOP-14), Both With Or Without The Monoclonal Anti-CD20 Antibody Rituximab In Patients Aged 61 To 80 Years With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
7 A Prospective Randomised Phase III Trial of Early Hospital Discharge Versus Standard Inpatient Management of Cancer Patients With Low-Risk Febrile Neutropenia Receiving Oral Antibiotics. Oral Antibiotics for Neutropenic Sepsis Giving Early Hospital Discharge [ORANGE] Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
8 Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients Unknown status NCT03023358 Phase 3 chidamide;cyclophosphamide;liposomal doxorubicin;vincristine;prednisone
9 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
10 Phase III Study of VCAP-AMP-VECP vs. Biweekly CHOP in Aggressive Adult T-cell Leukemia-lymphoma (ATLL): Japan Clinical Oncology Group Study, JCOG9801. Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
11 A Phase III Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Fragmin (5,000 IU Subcutaneously) in Preventing Catheter-Related Complications When Given Daily to Cancer Patients With Central Venous Catheters Completed NCT00006083 Phase 3 Fragmin
12 A Phase III Double-Blind Equivalence Study of Two Different Formulations of Slow-Release Morphine Followed by a Randomization Between Dextromethorphan or Placebo Plus Statex SR for Chronic Cancer Pain Relief in Terminally Ill Patients Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
13 Preparatory Aid to Improve Decision Making About Cancer Clinical Trials (PRE-ACT) Completed NCT00750009 Phase 3
14 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
15 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
16 The Use of American Ginseng (Panax Quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind, Placebo-Controlled Phase III Study Completed NCT00719563 Phase 3 American ginseng
17 Phase III Randomized Trial of an Opioid Titration Order Sheet Compared to Standard of Care in Patients With Cancer Related Pain. Completed NCT00666211 Phase 3
18 Phase III, Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Ondansetron in the Control of Chronic Nausea and Vomiting Not Due to Antineoplastic Therapy in Patients With Advanced Cancer Completed NCT00006348 Phase 3 ondansetron
19 Allogeneic Blood or Marrow Transplantation for Hematologic Malignancy and Aplastic Anemia Completed NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
20 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
21 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
22 A Randomized, Open-Label, Multicenter Study Of Darbepoetin Alfa Administered Once Every Two Weeks (Q2W) Compared With rHuEPO Administered Once Every Week (QW) For The Treatment Of Anemia In Subjects With Non-Myeloid Malignancies Receiving Multiple Chemotherapy Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
23 Does Hypericum Reduce Fatigue in Cancer Patients on Chemotherapy? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Completed NCT00005805 Phase 3
24 Vancomycin Versus Placebo in Persistently Febrile Granulocytopenic Patients Given Piperacillin/Tazobactam Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
25 A Phase III, Randomized Study of the Effects of Parenteral Iron, Oral Iron, or No Iron Supplementation on the Erythropoietic Response to Darbepoetin Alfa for Cancer Patients With Chemotherapy-Associated Anemia Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
26 Intensive Treatment For T-CELL Acute Lymphoblastic Leukemia and Advanced Stage Lymphoblastic Non-Hodgkin's Lymphoma: A Pediatric Oncology Group Phase III Study Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
27 ALLR3: An International Collaborative Trial for Relapsed and Refractory Acute Lymphoblastic Leukaemia (ALL) Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
28 A Multicenter Study of Treatment Protocol for Childhood Acute Lymphoblastic Leukemia in China, 2008. Completed NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
29 Treatment of Acute Lymphoblastic Leukemia in Children Completed NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
30 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Total Therapy for Adult T-lymphoblastic Lymphoma/Leukemia Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
31 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Target Total Therapy for Adult Early T-cell Progenitor Acute Lymphoblastic Leukemia/Lymphoma Recruiting NCT03553238 Phase 2, Phase 3 Chidamide;Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-Mercaptopurine;Etoposide;Cytarabine
32 A Randomized Trial for Adults With Newly Diagnosed Acute Lymphoblastic Leukemia Recruiting NCT01085617 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;imatinib mesylate;melphalan;mercaptopurine;methotrexate;nelarabine;pegaspargase;vincristine sulfate
33 Diffuse Large B Cell And Peripheral T Cell Non-Hodgkin's Lymphomas (NHL) In The Elderly. Influence Of Prolonged Oral Etoposide Added To CHOP Combination Chemotherapy In Patients With Good Physiological Status. An EORTC Randomized Phase II-III Trial Including Geriatric Assessment And Quality Of Life Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
34 CELTIC-1 (Clinical Evaluation of T-cell NHL With Cerdulatinib): A Phase 2b, Open Label, Multidose, Multinational Study of Cerdulatinib (PRT062070) in Patients With Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL) Withdrawn NCT04021082 Phase 2, Phase 3 Cerdulatinib
35 Chimeric Antigen Receptor-Modified pNK Cells for CD7 Positive Relapsed or Refractory Leukemia and Lymphoma Unknown status NCT02742727 Phase 1, Phase 2
36 A Phase II Evaluation of High Dose Chemotherapy and Autologous Stem Cell Transplantation for Intestinal T-cell Lymphomas Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
37 Alemtuzumab and CHOP Chemotherapy for Aggressive Histology Peripheral T Cell Lymphomas: A Multi-Centre Phase I and II Study Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
38 Non-Ablative Chemotherapeutic Conditioning Before Allogeneic Stem Cell Transplantation Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
39 Phase II Study of Arsenic Trioxide in Relapsed/Refractory Acute Leukemia and Blast Crisis of Chronic Myeloid Leukemia Unknown status NCT00003885 Phase 2 arsenic trioxide
40 Allograft of Hematopoietic Stem Cells With Reduced-intensity Conditioning From a HLA-haploidentical Family Donor: Phase II Study of Combined Immunosuppression Before and After Transplantation Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
41 Radiation Therapy in Combination With Indinavir / Ritonavir (Crixivan / Norvir) for the Treatment of Brain Metastases: a Randomized Phase II Study Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
42 DFCI ALL Adult Consortium Protocol: Adult ALL Trial Unknown status NCT01005758 Phase 2 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide phosphate;hydrocortisone sodium succinate;imatinib mesylate;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;prednisone;vincristine sulfate
43 MULTICENTRE TRIAL OF INTENSIFIED THERAPY FOR ADULT ALL (O5/93) Unknown status NCT00002531 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;teniposide;thioguanine;vincristine sulfate;vindesine
44 Randomised Placebo Controlled Trial of Faecal Microbiota Transplantation in Irritable Bowel Syndrome Unknown status NCT02423421 Phase 2
45 A Phase 2, Multicenter, Single-arm, Open-label Study to Evaluate the Safety and Efficacy of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide
46 Phase II Clinical Study of KW-0761 in Patients With CCR4-Positive Adult T-cell Leukemia-Lymphoma Completed NCT00920790 Phase 2
47 A Phase II, Multi-Center Open-Label, Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia With an Option of Long-Term Forodesine Hydrochloride (BCX-1777) Use Completed NCT00095381 Phase 2 forodesine hydrochloride (BCX-1777)
48 Phase II Trial of Nivolumab for HTLV-Associated Adult T Cell Leukemia/Lymphoma Completed NCT02631746 Phase 2
49 Multi-Center, Open-Label, Randomized Study of Anti-CCR4 Monoclonal Antibody KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
50 A Phase II Study of Lenalidomide in Patients With Relapsed or Refractory HTLV-1 Associated Adult T Cell Leukemia/Lymphoma Completed NCT01274533 Phase 2 Lenalidomide

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Genetic Tests for Leukemia, T-Cell, Chronic

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Anatomical Context for Leukemia, T-Cell, Chronic

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MalaCards organs/tissues related to Leukemia, T-Cell, Chronic:

40
T Cells, B Cells, Bone, Bone Marrow, Skin, Myeloid, Liver
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Publications for Leukemia, T-Cell, Chronic

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Articles related to Leukemia, T-Cell, Chronic:

(show top 50) (show all 8673)
# Title Authors PMID Year
1
Multiple recombinant events in human T-cell Leukemia virus Type 1: complete sequences of recombinant African strains. 61
32249692 2020
2
Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway. 61
32020591 2020
3
High-yield production in E. coli and characterization of full-length functional p13II protein from human T-cell leukemia virus type 1. 61
32360379 2020
4
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. 61
32126228 2020
5
lncRNA TCL6 correlates with immune cell infiltration and indicates worse survival in breast cancer. 61
31960363 2020
6
Human T cell lymphotropic virus type-1 associated lymphoma presenting as an intramuscular mass of the calf. 61
32076761 2020
7
Efficacy and Safety of the Modified EPOCH Regimen (Etoposide, Vincristine, Doxorubicin, Carboplatin, and Prednisolone) for Adult T-cell Leukemia/Lymphoma: A Multicenter Retrospective Study. 61
32312633 2020
8
Molecular targeting of PD-1 signaling pathway as a novel therapeutic approach in HTLV-1 infection. 61
32283259 2020
9
Improved survival for skin-primary presentation of adult T-cell leukemia/lymphoma (ATLL). 61
31765683 2020
10
HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling. 61
32471947 2020
11
PRMT5 Is Required for Bovine Leukemia Virus Infection In Vivo and Regulates BLV Gene Expression, Syncytium Formation, and Glycosylation In Vitro. 61
32560231 2020
12
Rapid and label-free electrochemical DNA biosensor based on a facile one-step electrochemical synthesis of rGO-Ppy-(L-Cys)- AuNPs nanocomposite for the HTLV-1 oligonucleotide detection. 61
32542764 2020
13
Hospital admissions in individuals with HTLV-1 infection in Spain. 61
32073449 2020
14
Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function. 61
32487757 2020
15
The effect of alcoholic extract from Eucalyptus camaldulensis leaves on HTLV-1 Tax activities. 61
32564665 2020
16
Defining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay. 61
31488561 2020
17
T-cell prolymphocytic leukemia: Review of an entity and its differential diagnostic considerations. 61
32543075 2020
18
Current understandings on T-cell prolymphocytic leukemia and its association with TCL1 proto-oncogene. 61
32247279 2020
19
Structural basis of host protein hijacking in human T-cell leukemia virus integration. 61
32561747 2020
20
Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype. 61
32555298 2020
21
Lymphomatous Adult T-cell Leukemia/Lymphoma with Anaplastic Morphology in a Country non-Endemic for HTLV: A Mimicker of Anaplastic Large Cell Lymphoma. 61
32516451 2020
22
Lymphomatous Adult T-cell Leukemia/Lymphoma with Anaplastic Morphology in a Country non-Endemic for HTLV: A Mimicker of Anaplastic Large Cell Lymphoma. 61
32510673 2020
23
Corrigendum to "Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphomaˮ [Biochem. Biophys. Res. Commun. 485 (1) 2017 144-151]. 61
32553628 2020
24
Immunophenotypic analysis of cerebrospinal fluid reveals concurrent development of ATL in the CNS of a HAM/TSP patient. 61
31930455 2020
25
Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia/lymphoma. 61
32272181 2020
26
Phylogenetic and phylodynamic study of Human T-cell lymphotropic virus Type 1 (HTLV-1) in Iran. 61
32561293 2020
27
Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques. 61
32576215 2020
28
Erythroderma: a prospective study of 309 patients followed for 12 years in a tertiary center. 61
32555205 2020
29
HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors. 61
32557883 2020
30
A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe. 61
32517809 2020
31
Clinicopathological analysis of immunohistochemical expression of CD47 and SIRPα in adult T-cell leukemia/lymphoma. 61
32569413 2020
32
MALT-1 as a novel therapeutic target for adult T-cell leukemia. 61
32574386 2020
33
CD4-/CD8+ adult T-cell leukemia/lymphoma with unusual morphology presenting as ascites and pleural effusion. 61
31820571 2020
34
Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis. 61
32160278 2020
35
Successful treatment with brentuximab vedotin for relapsed and refractory adult T cell leukemia. 61
31934889 2020
36
Association of TLX1 gene polymorphisms with the risk of acute lymphoblastic leukemia and B lineage acute lymphoblastic leukemia in Han Chinese children. 61
32488880 2020
37
Clinical efficacy of mogamulizumab for relapsed/refractory aggressive adult T-cell leukemia/lymphoma: A retrospective analysis. 61
32564395 2020
38
Predicting the future: adult T-cell leukemia. 61
32497221 2020
39
The roles of programmed death ligand 1 in virus-associated cancers. 61
32470632 2020
40
RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1. 61
31768017 2020
41
Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 12. 61
32422132 2020
42
Functional properties and sequence variation of HTLV-1 p13. 61
32398094 2020
43
Antiretroviral Therapy in HTLV-1 Infection: An Updated Overview. 61
32369988 2020
44
Clinical features and human T-cell leukemia virus type-1 (HTLV-1) proviral load in HTLV-1-positive patients with rheumatoid arthritis: Baseline data in a single center cohort study. 61
30938551 2020
45
Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells. 61
32369565 2020
46
Synthetic (E)-3-Phenyl-5-(phenylamino)-2-styryl-1,3,4-thiadiazol-3-ium Chloride Derivatives as Promising Chemotherapy Agents on Cell Lines Infected with HTLV-1. 61
32486038 2020
47
Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis using the new oral demethylating agent OR-2100. 61
32391874 2020
48
Long-term prognosis in kidney transplant recipients with human T-cell leukemia virus type 1 infection. 61
32386274 2020
49
High prevalence of human T-cell leukemia virus type-1b genotype among blood donors in Gabon, Central Africa. 61
32415686 2020
50
RNF8 Dysregulation and Down-regulation During HTLV-1 Infection Promote Genomic Instability in Adult T-Cell Leukemia. 61
32453758 2020
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Variations for Leukemia, T-Cell, Chronic

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Expression for Leukemia, T-Cell, Chronic

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Search GEO for disease gene expression data for Leukemia, T-Cell, Chronic.
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Pathways for Leukemia, T-Cell, Chronic

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GO Terms for Leukemia, T-Cell, Chronic

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Sources for Leukemia, T-Cell, Chronic

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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