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MCID: LKM005
MIFTS: 35

Leukemia, T-Cell, Chronic

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Leukemia, T-Cell, Chronic

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MalaCards integrated aliases for Leukemia, T-Cell, Chronic:

Name: Leukemia, T-Cell, Chronic 53 72
Chronic T-Cell Leukemia 53
Leukemia, T-Cell 72
T-Cell Leukemia 53

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Blood diseases Immune diseases
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UMLS 72 C0023492 C0023494
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Summaries for Leukemia, T-Cell, Chronic

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MalaCards based summary : Leukemia, T-Cell, Chronic, also known as chronic t-cell leukemia, is related to adult t-cell leukemia and human t-cell leukemia virus type 1. The drugs Zidovudine and Valproic acid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone.

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Related Diseases for Leukemia, T-Cell, Chronic

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Diseases in the T-Cell Leukemia family:

Adult T-Cell Leukemia Acute T Cell Leukemia
Human T-Cell Leukemia Virus Type 1 Human T-Cell Leukemia Virus Type 2
Human T-Cell Leukemia Virus Type 3 Leukemia, B-Cell, Chronic
Leukemia, T-Cell, Chronic

Diseases related to Leukemia, T-Cell, Chronic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 536)
# Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 13.1
2 human t-cell leukemia virus type 1 12.9
3 human t-cell leukemia virus type 2 12.8
4 acute t cell leukemia 12.7
5 pediatric t-cell leukemia 12.6
6 human t-cell leukemia virus type 3 12.6
7 n syndrome 12.0
8 t-cell adult acute lymphocytic leukemia 11.9
9 htlv-1 associated myelopathy/tropical spastic paraparesis 11.9
10 myelopathy, htlv-1-associated 11.8
11 tropical spastic paraparesis 11.8
12 t-cell prolymphocytic leukemia 11.7
13 glut1 deficiency syndrome 1 11.3
14 retrovirus-associated myelopathy 11.3
15 follicular lymphoma 11.2
16 lymphoma 11.1
17 agammaglobulinemia 11.1
18 hepatosplenic t-cell lymphoma 11.1
19 spastic paraparesis 11.0
20 chronic interstitial cystitis 10.9
21 leukemia, acute lymphoblastic 10.8
22 precursor t-cell acute lymphoblastic leukemia 10.8
23 alcoholic hepatitis 10.8
24 hematopoietic stem cell transplantation 10.8
25 human immunodeficiency virus type 1 10.7
26 severe combined immunodeficiency 10.7
27 mycosis fungoides 10.7
28 acquired immunodeficiency syndrome 10.7
29 cutaneous t cell lymphoma 10.6
30 peripheral t-cell lymphoma 10.6
31 lymphoproliferative syndrome 10.6
32 b-cell lymphoma 10.6
33 graft-versus-host disease 10.5
34 immune deficiency disease 10.5
35 prolymphocytic leukemia 10.5
36 strongyloidiasis 10.5
37 uveitis 10.5
38 hairy cell leukemia 10.5
39 neutropenia 10.5
40 acute leukemia 10.5
41 exanthem 10.5
42 chromosomal triplication 10.5
43 bone resorption disease 10.5
44 lymphoma, hodgkin, classic 10.4
45 hypereosinophilic syndrome 10.4
46 lymphosarcoma 10.4
47 retinoblastoma 10.4
48 lymphoma, non-hodgkin, familial 10.4
49 familial retinoblastoma 10.4
50 stomatitis 10.4

Graphical network of the top 20 diseases related to Leukemia, T-Cell, Chronic:



Diseases related to Leukemia, T-Cell, Chronic
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Symptoms & Phenotypes for Leukemia, T-Cell, Chronic

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Drugs & Therapeutics for Leukemia, T-Cell, Chronic

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Drugs for Leukemia, T-Cell, Chronic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 348)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zidovudine Approved Phase 4 30516-87-1 35370
2
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
3
Peginterferon alfa-2b Approved Phase 4 99210-65-8, 215647-85-1
4 Anti-HIV Agents Phase 4
5 Anti-Retroviral Agents Phase 4
6 Interferon alpha-2 Phase 4
7 Interferon-alpha Phase 4
8 Reverse Transcriptase Inhibitors Phase 4
9 interferons Phase 4
10 GABA Agents Phase 4
11 Anticonvulsants Phase 4
12 Antimanic Agents Phase 4
13
Vindesine Approved, Investigational Phase 3 59917-39-4, 53643-48-4 40839
14
Clavulanate Approved, Vet_approved Phase 3 58001-44-8 5280980
15
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
16
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
17
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
18
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
19 Orange Approved Phase 3
20
Thioguanine Approved Phase 3 154-42-7 2723601
21
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
22
Dalteparin Approved Phase 3 9005-49-6
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
24
Morphine Approved, Investigational Phase 3 57-27-2 5288826
25
Dextromethorphan Approved Phase 3 125-71-3 5360696 5362449
26
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
27
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
28
Ofloxacin Approved Phase 3 82419-36-1 4583
29
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
30
Darbepoetin alfa Approved, Investigational Phase 3 11096-26-7, 209810-58-2
31
Tazobactam Approved Phase 3 89786-04-9 123630
32
Piperacillin Approved Phase 3 66258-76-2 43672
33
Vancomycin Approved Phase 3 1404-90-6 441141 14969
34
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
35
Melphalan Approved Phase 3 148-82-3 460612 4053
36
Daunorubicin Approved Phase 3 20830-81-3 30323
37
rituximab Approved Phase 3 174722-31-7 10201696
38
Idarubicin Approved Phase 2, Phase 3 58957-92-9 42890
39
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
41
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
42
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
43
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
44
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
45
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
46
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
47
Carboplatin Approved Phase 2, Phase 3 41575-94-4 10339178 498142 38904
48
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
49
leucovorin Approved Phase 3 58-05-9 143 6006
50
Pegaspargase Approved, Investigational Phase 3 130167-69-0

Interventional clinical trials:

(show top 50) (show all 366)
# Name Status NCT ID Phase Drugs
1 HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL) Pilot Study of Combination Therapy With CHOP-Zenapax (CHOP-daclizumab) Completed NCT01418430 Phase 4 CHOP-daclizumab
2 HTLV Blot 2.4 Post-Market Clinical Study of Neurological Disorders and HTLV Positive Specimens Completed NCT03226119 Phase 4
3 Prospective Study of the Molecular Characteristics of Sensitive and Resistant Disease in Patients With HTLV-I Associated Adult T Cell Leukemia Treated With Zidovudine (AZT) Plus Interferon Alpha-2b Terminated NCT00854581 Phase 4 Valproic Acid;Zidovudine
4 A Randomized Double-Blind Controlled Trial of Ketamine Versus Placebo in Conjunction With Best Pain Management in Neuropathic Pain in Cancer Patients Unknown status NCT01316744 Phase 3 ketamine hydrochloride
5 Randomised Study Comparing 6 And 8 Cycles Of Chemotherapy With CHOP ( Cyclophosphamide, Doxorubicin, Vincristine And Prednisone) At 14-Day Intervals (CHOP-14), Both With Or Without The Monoclonal Anti-CD20 Antibody Rituximab In Patients Aged 61 To 80 Years With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
6 A Prospective Randomised Phase III Trial of Early Hospital Discharge Versus Standard Inpatient Management of Cancer Patients With Low-Risk Febrile Neutropenia Receiving Oral Antibiotics. Oral Antibiotics for Neutropenic Sepsis Giving Early Hospital Discharge [ORANGE] Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
7 Compared the Efficacy and Safety of CDOP Combined With Chidamide and CDOP in de Novo Peripheral T Cell Lymphoma Patients Unknown status NCT03023358 Phase 3 chidamide;cyclophosphamide;liposomal doxorubicin;vincristine;prednisone
8 The Value of Dexamethasone Versus Prednisolone During Induction and Maintenance Therapy of Prolonged Versus Conventional Duration of L-Asparaginase Therapy During Consolidation and Late Intensification, and of Corticosteroid + VCR Pulses During Maintenance in Acute Lymphoblastic Leukemia and Lymphoblastic Non-Hodgkin Lymphoma of Childhood Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
9 Phase III Study of VCAP-AMP-VECP vs. Biweekly CHOP in Aggressive Adult T-cell Leukemia-lymphoma (ATLL): Japan Clinical Oncology Group Study, JCOG9801. Completed NCT00145002 Phase 3 VCAP-AMP-VECP with G-CSF and intrathecal prophylaxis;biweekly-CHOP with G-CSF and intrathecal prophylaxis
10 A Phase III Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of Fragmin (5,000 IU Subcutaneously) in Preventing Catheter-Related Complications When Given Daily to Cancer Patients With Central Venous Catheters Completed NCT00006083 Phase 3 Fragmin
11 A Phase III Double-Blind Equivalence Study of Two Different Formulations of Slow-Release Morphine Followed by a Randomization Between Dextromethorphan or Placebo Plus Statex SR for Chronic Cancer Pain Relief in Terminally Ill Patients Completed NCT00003687 Phase 3 dextromethorphan hydrobromide;morphine sulfate
12 Preparatory Aid to Improve Decision Making About Cancer Clinical Trials (PRE-ACT) Completed NCT00750009 Phase 3
13 The Use of American Ginseng (Panax Quinquefolius) to Improve Cancer-Related Fatigue: A Randomized, Double-Blind, Placebo-Controlled Phase III Study Completed NCT00719563 Phase 3 American ginseng
14 Phase III Randomized Trial of an Opioid Titration Order Sheet Compared to Standard of Care in Patients With Cancer Related Pain. Completed NCT00666211 Phase 3
15 A Multicenter, Double-Blind, Randomized, Comparative Study To Evaluate The Safety, Tolerability, And Efficacy Of MK-0991 Versus (Amphotericin B) Liposome For Injection As Empirical Therapy In Patients With Persistent Fever And Neutropenia Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
16 A Strategic Study to Determine the Optimal Moment to Initiate Systemic Antifungal Therapy With Ambisome in Granulocytopenic Cancer Patients With Unexplained Fever Refractory to Empirical Antibacterials Completed NCT00003938 Phase 3 liposomal amphotericin B
17 Phase III, Randomized, Double-Blind, Placebo-Controlled Crossover Trial of Ondansetron in the Control of Chronic Nausea and Vomiting Not Due to Antineoplastic Therapy in Patients With Advanced Cancer Completed NCT00006348 Phase 3 ondansetron
18 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
19 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
20 A Randomized, Open-Label, Multicenter Study Of Darbepoetin Alfa Administered Once Every Two Weeks (Q2W) Compared With rHuEPO Administered Once Every Week (QW) For The Treatment Of Anemia In Subjects With Non-Myeloid Malignancies Receiving Multiple Chemotherapy Completed NCT00070382 Phase 3 darbepoetin alfa;epoetin alfa
21 A Phase III, Randomized Study of the Effects of Parenteral Iron, Oral Iron, or No Iron Supplementation on the Erythropoietic Response to Darbepoetin Alfa for Cancer Patients With Chemotherapy-Associated Anemia Completed NCT00661999 Phase 3 sodium ferric gluconate complex in sucrose
22 Does Hypericum Reduce Fatigue in Cancer Patients on Chemotherapy? A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Completed NCT00005805 Phase 3
23 Vancomycin Versus Placebo in Persistently Febrile Granulocytopenic Patients Given Piperacillin/Tazobactam Completed NCT00003805 Phase 3 piperacillin sodium;piperacillin-tazobactam;tazobactam sodium;vancomycin
24 A Phase III Study of Involved Field Radiation Therapy (IFRT) in Patients With Histologically Aggressive Non-Hodgkin's Lymphoma Following High Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation (ASCT) Completed NCT00031668 Phase 3
25 Intensive Treatment For T-CELL Acute Lymphoblastic Leukemia and Advanced Stage Lymphoblastic Non-Hodgkin's Lymphoma: A Pediatric Oncology Group Phase III Study Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
26 ALLR3: An International Collaborative Trial for Relapsed and Refractory Acute Lymphoblastic Leukaemia (ALL) Completed NCT00967057 Phase 3 asparaginase;dexamethasone;idarubicin;methotrexate;mitoxantrone hydrochloride;pegaspargase;vincristine sulfate
27 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Target Total Therapy for Adult Early T-cell Progenitor Acute Lymphoblastic Leukemia/Lymphoma Recruiting NCT03553238 Phase 2, Phase 3 Chidamide;Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-Mercaptopurine;Etoposide;Cytarabine
28 An Open-Label, One-Arm, Multi-Site Trial of Precision Diagnosis Directing Histone Deacetylase Inhibitor Chidamide Total Therapy for Adult T-lymphoblastic Lymphoma/Leukemia Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
29 A Randomized Trial for Adults With Newly Diagnosed Acute Lymphoblastic Leukemia Recruiting NCT01085617 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;imatinib mesylate;melphalan;mercaptopurine;methotrexate;nelarabine;pegaspargase;vincristine sulfate
30 Allogeneic Blood or Marrow Transplantation for Hematologic Malignancy and Aplastic Anemia Active, not recruiting NCT00003816 Phase 2, Phase 3 busulfan;carboplatin;cyclophosphamide;etoposide;fludarabine phosphate;melphalan;thiotepa
31 A Multicenter Study of Treatment Protocol for Childhood Acute Lymphoblastic Leukemia in China, 2008. Active, not recruiting NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
32 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
33 CELTIC-1 (Clinical Evaluation of T-cell NHL With Cerdulatinib): A Phase 2b, Open Label, Multidose, Multinational Study of Cerdulatinib (PRT062070) in Patients With Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL) Not yet recruiting NCT04021082 Phase 2, Phase 3 Cerdulatinib
34 Diffuse Large B Cell And Peripheral T Cell Non-Hodgkin's Lymphomas (NHL) In The Elderly. Influence Of Prolonged Oral Etoposide Added To CHOP Combination Chemotherapy In Patients With Good Physiological Status. An EORTC Randomized Phase II-III Trial Including Geriatric Assessment And Quality Of Life Terminated NCT00060385 Phase 2, Phase 3 CHOP regimen;EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
35 A Phase I-II Trial of Brentuximab Vedotin Plus Rituximab as Frontline Therapy for Patients With CD30+ and/or EBV+ Lymphomas Unknown status NCT01805037 Phase 1, Phase 2 brentuximab vedotin
36 Chimeric Antigen Receptor-Modified pNK Cells for CD7 Positive Relapsed or Refractory Leukemia and Lymphoma Unknown status NCT02742727 Phase 1, Phase 2
37 A Phase II Evaluation of High Dose Chemotherapy and Autologous Stem Cell Transplantation for Intestinal T-cell Lymphomas Unknown status NCT00669812 Phase 2 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
38 Alemtuzumab and CHOP Chemotherapy for Aggressive Histology Peripheral T Cell Lymphomas: A Multi-Centre Phase I and II Study Unknown status NCT00363090 Phase 1, Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
39 Non-Ablative Chemotherapeutic Conditioning Before Allogeneic Stem Cell Transplantation Unknown status NCT00008307 Phase 2 cyclosporine;fludarabine phosphate;melphalan;methylprednisolone;mycophenolate mofetil
40 Phase II Study of Arsenic Trioxide in Relapsed/Refractory Acute Leukemia and Blast Crisis of Chronic Myeloid Leukemia Unknown status NCT00003885 Phase 2 arsenic trioxide
41 Allograft of Hematopoietic Stem Cells With Reduced-intensity Conditioning From a HLA-haploidentical Family Donor: Phase II Study of Combined Immunosuppression Before and After Transplantation Unknown status NCT00740467 Phase 2 busulfan;cyclophosphamide;cyclosporine;fludarabine phosphate;mycophenolate mofetil
42 Radiation Therapy in Combination With Indinavir / Ritonavir (Crixivan / Norvir) for the Treatment of Brain Metastases: a Randomized Phase II Study Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
43 DFCI ALL Adult Consortium Protocol: Adult ALL Trial Unknown status NCT01005758 Phase 2 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide phosphate;hydrocortisone sodium succinate;imatinib mesylate;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;prednisone;vincristine sulfate
44 MULTICENTRE TRIAL OF INTENSIFIED THERAPY FOR ADULT ALL (O5/93) Unknown status NCT00002531 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;teniposide;thioguanine;vincristine sulfate;vindesine
45 Randomised Placebo Controlled Trial of Faecal Microbiota Transplantation in Irritable Bowel Syndrome Unknown status NCT02423421 Phase 2
46 A Phase 2, Multicenter, Single-arm, Open-label Study to Evaluate the Safety and Efficacy of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma Completed NCT01724177 Phase 2 Lenalidomide
47 Phase II Clinical Study of KW-0761 in Patients With CCR4-Positive Adult T-cell Leukemia-Lymphoma Completed NCT00920790 Phase 2
48 A Phase II, Multi-Center Open-Label, Repeat-Dose of Forodesine Hydrochloride (BCX-1777) Infusion in Patients With Advanced T-Cell Leukemia With an Option of Long-Term Forodesine Hydrochloride (BCX-1777) Use Completed NCT00095381 Phase 2 forodesine hydrochloride (BCX-1777)
49 Multi-Center, Open-Label, Randomized Study of Anti-CCR4 Monoclonal Antibody KW-0761 or Investigator's Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL) Completed NCT01626664 Phase 2 Pralatrexate;gemcitabine plus oxaliplatin;DHAP
50 A Phase II Study of Lenalidomide in Patients With Relapsed or Refractory HTLV-1 Associated Adult T Cell Leukemia/Lymphoma Completed NCT01274533 Phase 2 Lenalidomide

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Genetic Tests for Leukemia, T-Cell, Chronic

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Anatomical Context for Leukemia, T-Cell, Chronic

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MalaCards organs/tissues related to Leukemia, T-Cell, Chronic:

41
T Cells, B Cells, Bone, Bone Marrow, Skin, Myeloid, Liver
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Publications for Leukemia, T-Cell, Chronic

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Articles related to Leukemia, T-Cell, Chronic:

(show top 50) (show all 8452)
# Title Authors PMID Year
1
Comparative transcriptome analysis of peripheral blood mononuclear cells in renal transplant recipients in everolimus- and tacrolimus-based immunosuppressive therapy. 38
31238062 2019
2
Complete sequence of human T cell leukemia virus type 1 in ATLL patients from Northeast Iran, Mashhad revealed a prematurely terminated protease and an elongated pX open reading frame III. 38
31102740 2019
3
Conflicting effects of poly(ADP-ribose) polymerase inhibitor on cell-mediated and virion-mediated HTLV-1 infection. 38
31299194 2019
4
Thymoquinone enhances the anticancer activity of doxorubicin against adult T-cell leukemia in vitro and in vivo through ROS-dependent mechanisms. 38
31278946 2019
5
MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells. 38
31266772 2019
6
Ongoing issues with the management of children with Constitutional Mismatch Repair Deficiency syndrome. 38
31233827 2019
7
Noncoding RNA transcription at enhancers and genome folding in cancer. 38
31228211 2019
8
Development and evaluation of human T-cell leukemia virus-1 and -2 multiplex quantitative PCR. 38
31429972 2019
9
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure. 38
31233774 2019
10
A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia-lymphoma. 38
30546068 2019
11
Endoscopic and clinicopathological characteristics of gastrointestinal adult T-cell leukemia/lymphoma. 38
31392053 2019
12
Clinical Features, Pathological Features, and Treatment Outcomes of 22 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated with a Humanized CCR4 Antibody (Mogamulizumab) at a Single Institution during a 6-year Period (2012-2018). 38
30996180 2019
13
Dermatological manifestations in patients with human T-cell lymphotropic virus at a reference service in Amazon. 38
30888053 2019
14
Novel Interactions between the Human T-Cell Leukemia Virus Type 1 Antisense Protein HBZ and the SWI/SNF Chromatin Remodeling Family: Implications for Viral Life Cycle. 38
31142665 2019
15
Comparative virology of HTLV-1 and HTLV-2. 38
31391116 2019
16
Current approaches for detection of human T-lymphotropic virus Type 1: A systematic review. 38
30633358 2019
17
Epidemiology of blood-borne viral infections in Afghanistan. 38
31134354 2019
18
Hodgkin-like adult T-cell leukemia/lymphoma that developed during the follow-up of HTLV-1 associated myelopathy/tropical spastic paraparesis. 38
31391405 2019
19
Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 Activities In Vitro and In Vivo. 38
31167921 2019
20
Clinicopathological analysis of sinonasal malignant lymphoma in an HTLV-1 endemic area in Japan-special focus on primary sinonasal diffuse large B-cell lymphoma. 38
31391402 2019
21
Human leukocyte antigen class II expression is a good prognostic factor in adult T-cell leukemia/lymphoma. 38
30630986 2019
22
Efficacy of Allogeneic Hematopoietic Cell Transplantation in Human T Cell Lymphotropic Virus Type 1-Associated Adult T Cell Leukemia/Lymphoma: Results of a Systematic Review/Meta-Analysis. 38
31132453 2019
23
The prevalence of human T-cell leukemia virus in blood donors in China. 38
30985961 2019
24
Regulation of Latency in the Human T Cell Leukemia Virus, HTLV-1. 38
31283437 2019
25
HTLV-1 bZIP factor upregulates the expression of ICAM-1 to facilitate HTLV-1 infection. 38
31315993 2019
26
Dimorphism in the T-cell receptor constant region affects T-cell function, phenotype and HIV outcome. 38
30932962 2019
27
Adult T-Cell Leukemia After Deceased Donor Liver Transplantation for Acute Liver Failure: A Case Report. 38
31303413 2019
28
Therapeutic Efficacy of Etretinate on Cutaneous-type Adult T-cell Leukemia-Lymphoma. 38
31017247 2019
29
Plasma exchange eliminates residual mogamulizumab but does not warrant prompt recovery of peripheral Treg levels. 38
31303512 2019
30
Mogamulizumab Treatment Elicits Autoantibodies Attacking the Skin in Patients with Adult T-Cell Leukemia-Lymphoma. 38
31018922 2019
31
Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease. 38
31182480 2019
32
Cutaneous manifestations of adult T-cell leukemia/lymphoma. 38
31387753 2019
33
Pleural Effusion Due to Adult T Cell Leukemia. 38
31292402 2019
34
The regulation of NDRG2 expression during ATLL development after HTLV-1 infection. 38
31295529 2019
35
Effects of radiation based on whole-body irradiation in HTLV-1-infected mice. 38
31322703 2019
36
High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments. 38
31292228 2019
37
Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk). 38
30999237 2019
38
Human oncoviruses: Mucocutaneous manifestations, pathogenesis, therapeutics, and prevention: Hepatitis viruses, human T-cell leukemia viruses, herpesviruses, and Epstein-Barr virus. 38
30502415 2019
39
A 9‑lncRNA risk score system for predicting the prognosis of patients with hepatitis B virus‑positive hepatocellular carcinoma. 38
31115573 2019
40
Prevalence of human T-cell lymphotropic virus and the socio-demographic and risk factors associated with the infection among post-natal clinics women in Zaria, Nigeria. 38
31339431 2019
41
The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability. 38
31299491 2019
42
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia. 38
31266935 2019
43
Essential Role of HTLV-1 orf-I in Lethal Proliferation of CD4+ Cells in Humanized Mice. 38
31315992 2019
44
Satureja hortensis induces cell death and inhibited cell cycle progression in K562 myelogenous and Jurkat T cell leukemia cell lines. 38
31204615 2019
45
Circulating miR-29c, miR-30c, miR-193a-5p and miR-885-5p: Novel potential biomarkers for HTLV-1 infection diagnosis. 38
31242452 2019
46
Structural and functional consequences of the STAT5BN642H driver mutation. 38
31175292 2019
47
Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma. 38
30702500 2019
48
Mogamulizumab for the Treatment of Adult T-cell Leukemia/Lymphoma. 38
30981611 2019
49
PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia/Lymphoma. 38
30862694 2019
50
HTLV-1-associated adult T-cell leukemia/lymphoma with disseminated strongyloidiasis. 38
31196878 2019
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Variations for Leukemia, T-Cell, Chronic

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Expression for Leukemia, T-Cell, Chronic

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Search GEO for disease gene expression data for Leukemia, T-Cell, Chronic.
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Pathways for Leukemia, T-Cell, Chronic

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GO Terms for Leukemia, T-Cell, Chronic

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Sources for Leukemia, T-Cell, Chronic

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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