MCID: LKC003
MIFTS: 43

Leukocyte Disease

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Leukocyte Disease

MalaCards integrated aliases for Leukocyte Disease:

Name: Leukocyte Disease 12 15
Leukocyte Disorders 44 73
Abnormality of Leukocytes 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9500
ICD10 33 D72.9
ICD9CM 35 288 288.9
MeSH 44 D007960
SNOMED-CT 68 54097007
UMLS 73 C0023510

Summaries for Leukocyte Disease

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to neutrophilia, hereditary and high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement. An important gene associated with Leukocyte Disease is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include bone, bone marrow and lung, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Wikipedia : 76 White blood cells (also called leukocytes or leucocytes and abbreviated as WBCs) are the cells of the... more...

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 neutrophilia, hereditary 10.9
2 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.4 BCL6 MYC
3 tracheal lymphoma 10.4 CD5 MME
4 nodal marginal zone b-cell lymphoma 10.4 BCL6 MALT1
5 ovary sarcoma 10.4 CD34 MYC
6 heart lymphoma 10.4 BCL6 MME
7 ovarian angiosarcoma 10.4 CD34 MYC
8 colon lymphoma 10.4 BCL6 CD19 CD5
9 eye lymphoma 10.4 CD5 IL6 TLR9
10 indolent myeloma 10.4 B2M MYOM2
11 plasmablastic lymphoma 10.4 BCL6 CD38 MYC
12 seborrheic infantile dermatitis 10.4 CSF2 IL5
13 bladder lymphoma 10.3 CD19 CD5 MME
14 encapsulated thymoma 10.3 CD38 MME
15 breast myofibroblastoma 10.3 CD34 MME
16 b cell deficiency 10.3 CD19 KMT2D TLR9
17 multicentric castleman disease 10.3 BCL6 IL5 IL6
18 castleman disease 10.3 BCL6 IL5 IL6
19 richter's syndrome 10.3 CD38 CD5 MYC
20 adult lymphoma 10.3 CD5 CSF3 MYC
21 lymphoblastic lymphoma 10.3 BCL6 CD5 MME
22 splenic marginal zone lymphoma 10.3 BCL6 CD5 MALT1
23 yellow fever 10.3 IL5 IL6 TLR9
24 filariasis 10.3 IL5 IL6 TLR9
25 orbital granuloma 10.3 CD34 CSF3
26 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL6
27 meningoencephalitis 10.3 B2M IL6 TLR9
28 nasopharyngeal disease 10.3 CASP3 CCND1 MYC
29 reticulosarcoma 10.3 B2M BCL6 CASP3
30 ecthyma 10.3 CSF2 CSF3 MYOM2
31 aspergillosis 10.3 CSF2 IL5 TLR9
32 b-cell expansion with nfkb and t-cell anergy 10.3 B2M CD38 CD5
33 pharynx cancer 10.3 CASP3 CCND1 MYC
34 intravascular large b-cell lymphoma 10.3 B2M BCL6 CD5 MME
35 lymphocytic leukemia 10.3 CD38 CD5 MME MYC
36 trigonitis 10.3 CD34 CSF3
37 diffuse infiltrative lymphocytosis syndrome 10.3 CD19 CD38 SDC1
38 autoimmune disease of musculoskeletal system 10.3 CD19 IL6 TLR9
39 lymphoma, hodgkin, classic 10.3 BCL6 CD19 CD5 MME
40 prostate lymphoma 10.3 CD5 MALT1
41 bagassosis 10.3 IL5 IL6
42 b cell prolymphocytic leukemia 10.3 CD19 CD38 CD5 MYC
43 upper respiratory tract disease 10.3 IL5 IL6 MYOM2 TLR9
44 cervix disease 10.3 CASP3 CCND1 MYC TLR9
45 follicular lymphoma 10.3 BCL6 CCND1 MME MYC
46 breast lymphoma 10.3 BCL6 CD5
47 anterior scleritis 10.3 B2M CD19 CD5 IL5
48 male reproductive organ cancer 10.3 CASP3 CCND1 MYC TLR9
49 colonic disease 10.3 CASP3 CCND1 MYC TLR9
50 peripheral t-cell lymphoma 10.3 BCL6 CD5 MME

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:



Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

GenomeRNAi Phenotypes related to Leukocyte Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 BCL6 CCND1 CD34 CD5 CSF3 IL5

MGI Mouse Phenotypes related to Leukocyte Disease:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 B2M BAX BCL6 CASP3 CCND1 CD19
2 immune system MP:0005387 10.41 B2M BAX BCL6 CASP3 CCND1 CD19
3 cellular MP:0005384 10.37 B2M BAX BCL6 CASP3 CCND1 CD19
4 homeostasis/metabolism MP:0005376 10.36 B2M BAX BCL6 CASP3 CCND1 CD19
5 endocrine/exocrine gland MP:0005379 10.19 B2M BAX BCL6 CASP3 CCND1 CD38
6 integument MP:0010771 10.18 B2M CASP3 CCND1 CD19 CD34 CD5
7 mortality/aging MP:0010768 10.13 B2M BAX BCL6 CASP3 CCND1 CD19
8 digestive/alimentary MP:0005381 10.11 B2M CASP3 CCND1 CD19 IL5 IL6
9 neoplasm MP:0002006 10 B2M BAX CCND1 CD19 CD34 CSF2
10 liver/biliary system MP:0005370 9.91 B2M BCL6 CD19 IL5 IL6 MME
11 renal/urinary system MP:0005367 9.7 BAX CASP3 CD19 CSF2 CSF3 IL6
12 reproductive system MP:0005389 9.65 B2M BAX BCL6 CASP3 CCND1 CSF2
13 respiratory system MP:0005388 9.23 BAX BCL6 CASP3 CCND1 CSF2 IL5

Drugs & Therapeutics for Leukocyte Disease

Search Clinical Trials , NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

# Genetic test Affiliating Genes
1 Abnormality of Leukocytes 29

Anatomical Context for Leukocyte Disease

MalaCards organs/tissues related to Leukocyte Disease:

41
Bone, Bone Marrow, Lung, Liver, Colon, B Cells, Myeloid

Publications for Leukocyte Disease

Articles related to Leukocyte Disease:

# Title Authors Year
1
Leukocyte disorders: quantitative and qualitative disorders of the neutrophil, Part 1. ( 8559712 )
1996
2
Leukocyte disorders: quantitative and qualitative disorders of the neutrophil, part 2. ( 8775892 )
1996
3
Leukocyte function and nonmalignant leukocyte disorders. ( 8374630 )
1993
4
Diagnosis of leukocyte disorders with an automated haematology counter (Technicon H-1 analyser). ( 2802504 )
1989
5
Retinal blood velocity in patients with leukocyte disorders. ( 3190539 )
1988
6
The local inflammatory response in leukocyte disorders. ( 121576 )
1979
7
Functional leukocyte disorders. ( 471548 )
1979

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 B2M BCL6 CASP3 CCND1 CD19 CD34
2
Show member pathways
13.4 BAX CASP3 CCND1 CSF2 CSF3 IL5
3
Show member pathways
13.31 B2M BCL6 CASP3 CCND1 CSF2 CSF3
4
Show member pathways
13.05 B2M BAX CASP3 CCND1 CSF2 IL6
5
Show member pathways
12.98 BAX CASP3 CCND1 CD19 CSF3 IL6
6
Show member pathways
12.88 B2M CASP3 CCND1 IL5 IL6 MALT1
7
Show member pathways
12.85 BAX CASP3 CCND1 CSF2 MYC
8 12.84 BAX CASP3 CCND1 IL5 IL6 MYC
9
Show member pathways
12.46 BAX CASP3 CCND1 MYC
10 12.46 B2M BCL6 CD19 CD34 CD38 MALT1
11 12.43 BAX CCND1 CSF2 IL6 MYC
12
Show member pathways
12.41 CSF2 IL5 IL6 MALT1
13
Show member pathways
12.37 BCL6 CD19 MALT1 MYC
14
Show member pathways
12.37 CCND1 CSF2 CSF3 IL5 IL6 MYC
15
Show member pathways
12.36 BAX CASP3 CCND1 MYC
16
Show member pathways
12.32 CASP3 CSF2 CSF3 IL5 IL6
17 12.29 CASP3 CCND1 MYC SDC1
18 12.24 BAX CASP3 MALT1 MYC
19 12.23 BAX BCL6 CSF2 IL6 MYC
20 12.21 BAX CASP3 IL6 MALT1 TLR9
21
Show member pathways
12.19 BAX CASP3 CCND1 MYC
22 12.17 B2M BAX CASP3 CCND1 CD19 IL6
23 12.15 BAX CASP3 CCND1 MYC
24 12.14 BAX CASP3 CCND1 MYC
25 12.06 BAX CASP3 CCND1 IL6 MYC TLR9
26 12.02 CASP3 CCND1 IL6 MYC
27 11.99 BAX BCL6 CCND1 MYC
28 11.99 BCL6 CCND1 IL6 MYC
29 11.91 BAX CASP3 CCND1 IL6
30 11.87 CASP3 CSF2 IL6
31 11.87 BAX CASP3 CCND1 MYC
32
Show member pathways
11.85 CSF2 CSF3 IL6
33 11.8 BAX CSF2 IL5 IL6
34 11.76 CCND1 CD34 MYC
35
Show member pathways
11.74 CASP3 CSF2 IL5
36 11.72 CD19 CD34 CD38 CD5 CSF2 CSF3
37 11.67 CD19 CD34 CD38 CSF2 IL6 MME
38
Show member pathways
11.66 CCND1 CSF2 IL6
39 11.64 CSF2 CSF3 IL5 IL6
40 11.56 BAX CCND1 IL6
41 11.54 CSF2 CSF3 IL6
42 11.52 CASP3 CCND1 IL6 MYC
43 11.5 BAX CASP3 MYC
44 11.49 CSF3 IL6 SDC1 TLR9
45 11.46 CSF2 CSF3 IL5 IL6
46 11.42 BCL6 CD19 CD34 CD38 CD5 MME
47 11.37 CCND1 IL6 MYC
48 11.34 BAX CASP3 CSF2
49 11.26 CD19 CD34 CD38 CD5 CSF2 CSF3
50 11.2 BAX CSF2 CSF3 IL5 IL6

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 B2M CD19 CD34 CD5 SDC1

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.97 BAX BCL6 CASP3 CCND1 MYC
2 negative regulation of apoptotic process GO:0043066 9.95 BCL6 CASP3 CD38 IL6 MALT1 MYC
3 positive regulation of gene expression GO:0010628 9.93 CD34 CSF2 IL6 MYC TLR9
4 inflammatory response GO:0006954 9.91 BCL6 IL5 IL6 SDC1 TLR9
5 immune response GO:0006955 9.91 B2M CSF2 CSF3 IL5 IL6 TLR9
6 regulation of immune response GO:0050776 9.85 B2M BCL6 CD19 CD34
7 response to drug GO:0042493 9.85 B2M CASP3 CCND1 CD38 MYC
8 response to organic substance GO:0010033 9.79 CASP3 CCND1 SDC1
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 CSF3 IL5 IL6
10 response to wounding GO:0009611 9.74 BAX CASP3 MYC
11 response to estradiol GO:0032355 9.71 CASP3 CCND1 CD38 MYC
12 cellular response to organic substance GO:0071310 9.67 BAX CASP3 CCND1
13 response to glucocorticoid GO:0051384 9.67 CASP3 CCND1 IL6 SDC1
14 apoptotic signaling pathway GO:0097190 9.62 BAX CASP3 CD38 CD5
15 hypothalamus development GO:0021854 9.61 BAX MYC
16 negative regulation of bone resorption GO:0045779 9.61 CD38 IL6
17 positive regulation of immunoglobulin secretion GO:0051024 9.59 IL5 IL6
18 positive regulation of podosome assembly GO:0071803 9.58 CSF2 IL5
19 positive regulation of T cell cytokine production GO:0002726 9.56 B2M MALT1
20 positive regulation of cell proliferation GO:0008284 9.56 CCND1 CD38 CSF2 CSF3 IL5 IL6
21 re-entry into mitotic cell cycle GO:0000320 9.52 CCND1 MYC
22 positive regulation of B cell proliferation GO:0030890 9.46 BCL6 CD38 IL5 TLR9
23 response to molecule of bacterial origin GO:0002237 9.43 B2M MALT1 TLR9
24 cytokine-mediated signaling pathway GO:0019221 9.28 BCL6 CASP3 CCND1 CSF2 CSF3 IL5

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CSF2 CSF3 IL5 IL6
2 growth factor activity GO:0008083 8.92 CSF2 CSF3 IL5 IL6

Sources for Leukocyte Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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