MCID: LKC003
MIFTS: 41

Leukocyte Disease

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Leukocyte Disease

MalaCards integrated aliases for Leukocyte Disease:

Name: Leukocyte Disease 12 15
Leukocyte Disorders 44 70
Abnormality of Leukocytes 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9500
ICD9CM 34 288
MeSH 44 D007960
SNOMED-CT 67 191369001
ICD10 32 D72.9
UMLS 70 C0023510

Summaries for Leukocyte Disease

Disease Ontology : 12 A hematopoietic system disease that is located in white blood cells.

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to neutrophilia, hereditary and retinal vascular disease. An important gene associated with Leukocyte Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Prednisone and glucocorticoids have been mentioned in the context of this disorder. Affiliated tissues include white blood cells, bone marrow and neutrophil.

Wikipedia : 73 White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that... more...

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 558)
# Related Disease Score Top Affiliating Genes
1 neutrophilia, hereditary 32.3 U2AF1 IL6 CSF3
2 retinal vascular disease 30.4 MIR21 MIR17 MIR126 IL6 H2AC18
3 hypereosinophilic syndrome 10.9
4 schistosomiasis 10.6 IL5 IL4 IL13
5 scabies 10.6 CSF3 CD4 CCR6
6 esophageal candidiasis 10.6 CD8A CD4 CCR6
7 chlamydia 10.6 IL6 IL5 IL4
8 acute proliferative glomerulonephritis 10.6 ICOSLG CD4 CCR6
9 pneumonic tularemia 10.6 CD8A CD4 CCR6
10 immunodeficiency 16 10.6 ICOSLG CD8A CD4 CCR6
11 central nervous system hematologic cancer 10.6 KDM4C IRF4 CD4 CCR6
12 tularemia 10.6 CD8A CD4 CCR6
13 autoimmune glomerulonephritis 10.6 ICOSLG CD8A CD4 CCR6
14 mucormycosis 10.6 CSF3 CD4 CCR6
15 t-cell adult acute lymphocytic leukemia 10.6 IRF4 CD8A CD4 CCR6
16 primary thrombocytopenia 10.6 ICOSLG CD8A CD4 CCR6
17 norwegian scabies 10.6 IL5 CD8A CD4
18 anogenital venereal wart 10.6 H2AC18 CD8A CD4 CCR6
19 bullous skin disease 10.6 IL5 ICOSLG CD4 CCR6
20 blastomycosis 10.6 IL6 CD4 CCR6
21 immunoglobulin alpha deficiency 10.6 ICOSLG CD8A CD4 CCR6
22 autoimmune cholangitis 10.6 CD8A CD4 CCR6
23 mast cell neoplasm 10.6 U2AF1 ICOSLG H2AC18 CD8A
24 felty syndrome 10.6 H2AC18 CSF3 CD8A
25 anemia, autoimmune hemolytic 10.6 ICOSLG CD8A CD4 CCR6
26 childhood type dermatomyositis 10.6 IL6 ICOSLG CD4 CCR6
27 thrombocytopenia due to platelet alloimmunization 10.6 ICOSLG CD8A CD4 CCR6
28 t cell deficiency 10.6 ICOSLG CD8A CD4 CCR6
29 adult acute lymphocytic leukemia 10.6 CSF3 CD8A CD4 CCR6
30 chromium allergic contact dermatitis 10.6 IL5 IL4 IL13
31 conjunctivitis 10.6 IL6 IL5 IL4 IL13
32 hypersensitivity reaction type iii disease 10.6 IL6 ICOSLG CD4 CCR6
33 b-cell lymphoma 10.6 MIR21 MIR17 MIR155 MIR142 IRF4
34 progressive multifocal leukoencephalopathy 10.6 ICOSLG CD8A CD4 CCR6
35 immunodeficiency with hyper-igm, type 3 10.6 ICOSLG CD8A CD4
36 pre-malignant neoplasm 10.6 MIR17 MIR142 H2AC18 CCR6
37 miliary tuberculosis 10.6 CSF3 CD8A CD4
38 parasitic ectoparasitic infectious disease 10.6 IL4 H2AC18 CD4 CCR6
39 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 IL5 IL13
40 metal allergy 10.6 IL4 CD8A CD4
41 eosinophilic gastroenteritis 10.6 IL5 IL4 CSF3 CCR6
42 sialadenitis 10.6 ICOSLG CD4 CCR6
43 autoimmune disease of urogenital tract 10.6 ICOSLG H2AC18 CD8A CD4 CCR6
44 cork-handlers' disease 10.6 CD8A CD4
45 hepatic vascular disease 10.6 U2AF1 IL6 CSF3 CCR6
46 necrotic uveal melanoma 10.6 CD8A CD4
47 herpes zoster 10.6 ICOSLG CD8A CD4 CCR6
48 immune-complex glomerulonephritis 10.6 ICOSLG H2AC18 CD4
49 nut allergy 10.6 IL5 IL4 IL13 CCR6
50 igg4-related disease 10.6 IL4 ICOSLG CCR6

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:



Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

Drugs & Therapeutics for Leukocyte Disease

Drugs for Leukocyte Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2 glucocorticoids Phase 4
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Anti-Inflammatory Agents Phase 4
7
Benralizumab Approved, Investigational Phase 2, Phase 3 1044511-01-4
8 Respiratory System Agents Phase 2, Phase 3
9 Anti-Asthmatic Agents Phase 2, Phase 3
10 Pharmaceutical Solutions Phase 2, Phase 3
11 Antibodies Phase 2, Phase 3
12 Immunoglobulins Phase 2, Phase 3
13
Histidine Investigational, Nutraceutical Phase 2, Phase 3 71-00-1 6274
14
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
15
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes Completed NCT01524536 Phase 4 prednisone
2 A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects With Hypereosinophilic Syndrome (HES) Active, not recruiting NCT02130882 Phase 2, Phase 3 benralizumab
3 Cognitive Function in Leukocyte Disorders Completed NCT00005933
4 Effects of CPB-leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function. Completed NCT01469676
5 Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent Completed NCT00059423
6 Research Respiratory Tract Procedures Recruiting NCT00471250
7 Investigation of the Genetics of Hematologic Diseases Recruiting NCT02720679
8 An Expanded Access Study of the Feasibility of Using the CliniMACS® Device for CD34+ Cell Selection and T Cell Depletion for Graft-versus-Host Disease Prophylaxis in Alternative Donor Stem Cell Transplant Recipients Available NCT01200017

Search NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

# Genetic test Affiliating Genes
1 Abnormality of Leukocytes 29

Anatomical Context for Leukocyte Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Leukocyte Disease:

19
White Blood Cells

MalaCards organs/tissues related to Leukocyte Disease:

40
Bone Marrow, Neutrophil

Publications for Leukocyte Disease

Articles related to Leukocyte Disease:

(show all 14)
# Title Authors PMID Year
1
Establishment of a pediatric trigger tool based on Global Trigger Tool to identify adverse drug events of children: experience in a Chinese hospital. 61
32993580 2020
2
External validation of leukocytosis and neutrophilia as a prognostic marker in anal carcinoma treated with definitive chemoradiation. 61
28662871 2017
3
[Detection and initial management of the systemic inflammatory response syndrome in medicine emergency room: 24 hours follow-up in a general hospital]. 61
18769740 2008
4
Leukocyte disorders: quantitative and qualitative disorders of the neutrophil, part 2. 61
8775892 1996
5
Leukocyte disorders: quantitative and qualitative disorders of the neutrophil, Part 1. 61
8559712 1996
6
Leukocyte function and nonmalignant leukocyte disorders. 61
8374630 1993
7
Levels of human serum granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor under pathological conditions. 61
1377927 1992
8
Training and practice activities of hematology and medical oncology diplomates. 61
2297285 1990
9
Diagnosis of leukocyte disorders with an automated haematology counter (Technicon H-1 analyser). 61
2802504 1989
10
Retinal blood velocity in patients with leukocyte disorders. 61
3190539 1988
11
Influence of underlying disease process on the utility of cellulitis needle aspirates. 61
3190376 1988
12
[Leukocyte disorders in neonatal septicemia]. 61
3653612 1986
13
The local inflammatory response in leukocyte disorders. 61
121576 1979
14
Functional leukocyte disorders. 61
471548 1979

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 IRF4 IL6 IL5 IL4 IL13 CSF3
2
Show member pathways
13.24 IL6 IL5 IL4 IL13 CSF3 CD4
3
Show member pathways
12.78 IL6 IL5 IL4 IL13 ICOSLG CD8A
4
Show member pathways
12.54 IRF4 IL6 IL5 IL4 CD8A CD4
5
Show member pathways
12.53 IRF4 IL6 IL5 IL4 IL13 CD4
6 12.48 MIR21 MIR17 MIR155 MIR126 MIR125A
7
Show member pathways
12.36 IL6 IL5 IL4 IL13 CSF3
8
Show member pathways
12.29 IL6 IL5 IL4 IL13 CSF3
9
Show member pathways
12.21 IRF4 IL6 IL5 IL4 IL13
10 12.07 SDC1 ICOSLG CD8A CD4
11 11.94 IRF4 IL6 IL4 IL13
12 11.76 IL6 IL5 IL4 IL13
13 11.76 SDC1 IL6 IL5 IL4 CSF3 CD8A
14 11.73 IL6 IL5 IL4 CSF3 CD8A CD4
15 11.71 IRF4 IL6 CD8A CD4
16
Show member pathways
11.69 IRF4 IL5 IL4
17 11.62 IL6 IL5 IL4 ICOSLG CCR6
18 11.6 IRF4 IL5 IL4
19 11.57 IL6 IL5 IL4 IL13 CSF3
20 11.49 SDC1 IL6 CSF3
21 11.47 IL6 IL5 CSF3
22 11.47 IL6 IL4 IL13 CSF3
23 11.42 IL5 IL4 IL13 CD4
24 11.4 IRF4 IL5 IL4 IL13 CD8A CD4
25 11.24 IL6 IL5 IL4 IL13
26 11.17 IL5 IL4 IL13
27 10.7 IL6 IL5 IL4 IL13
28 10.56 IL6 IL5 IL4 IL13 CSF3 CD4

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 9.46 MIR21 MIR17 MIR126 MIR125A
2 external side of plasma membrane GO:0009897 9.43 SDC1 IL13 ICOSLG CD8A CD4 CCR6
3 extracellular space GO:0005615 9.36 MIR21 MIR17 MIR155 MIR142 MIR126 MIR125A

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 10.02 MIR21 MIR17 MIR155 MIR142 MIR126 MIR125A
2 positive regulation of cell proliferation GO:0008284 10 MIR21 KDM4C IL6 IL5 IL4 CSF3
3 positive regulation of gene expression GO:0010628 9.91 MIR21 MIR155 MIR125A KDM4C IL6 IL4
4 cellular response to lipopolysaccharide GO:0071222 9.87 MIR21 MIR17 IL6 CSF3
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 IL6 IL4 IL13
6 positive regulation of T cell proliferation GO:0042102 9.77 IL6 IL4 CD4
7 immune response GO:0006955 9.76 IL6 IL5 IL4 IL13 CSF3 CD8A
8 positive regulation of B cell proliferation GO:0030890 9.73 IL5 IL4 IL13
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 IL6 IL5 CSF3 CD4
10 negative regulation of inflammatory response GO:0050728 9.72 MIR155 MIR142 MIR126 IL4 IL13
11 negative regulation of endothelial cell apoptotic process GO:2000352 9.71 MIR126 IL4 IL13
12 positive regulation of sprouting angiogenesis GO:1903672 9.67 MIR155 MIR126 MIR125A
13 positive regulation of microglial cell activation GO:1903980 9.65 MIR155 MIR142
14 positive regulation of neuroinflammatory response GO:0150078 9.65 MIR142 IL6
15 positive regulation of activated T cell proliferation GO:0042104 9.65 MIR21 MIR155 ICOSLG
16 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.64 MIR17 MIR155
17 positive regulation of interleukin-13 production GO:0032736 9.64 IRF4 IL4
18 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.63 MIR155 MIR125A
19 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.63 MIR21 MIR17 IL6
20 positive regulation of metalloendopeptidase activity GO:1904685 9.62 MIR21 MIR17
21 positive regulation of mast cell degranulation GO:0043306 9.62 IL4 IL13
22 negative regulation of bicellular tight junction assembly GO:1903347 9.61 MIR155 MIR142
23 negative regulation of regulatory T cell differentiation GO:0045590 9.61 MIR21 MIR155
24 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.59 MIR21 IL6
25 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.58 MIR21 MIR17
26 T-helper 17 cell lineage commitment GO:0072540 9.58 IRF4 IL6
27 positive regulation of immunoglobulin production GO:0002639 9.58 IL6 IL5 IL13
28 positive regulation of interleukin-10 production GO:0032733 9.56 IRF4 IL6 IL4 IL13
29 negative regulation of complement-dependent cytotoxicity GO:1903660 9.51 IL4 IL13
30 T cell activation GO:0042110 9.35 IRF4 IL4 ICOSLG CD8A CD4
31 cytokine-mediated signaling pathway GO:0019221 9.23 SDC1 IRF4 IL6 IL5 IL4 IL13

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 IL6 IL5 IL4 CSF3
2 cytokine activity GO:0005125 9.55 IL6 IL5 IL4 IL13 CSF3
3 mRNA 3'-UTR binding GO:0003730 9.35 MIR21 MIR17 MIR142 MIR126 MIR125A
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR21 MIR17 MIR155 MIR142 MIR126 MIR125A

Sources for Leukocyte Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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