MCID: LKC003
MIFTS: 40

Leukocyte Disease

Categories: Blood diseases, Immune diseases

Aliases & Classifications for Leukocyte Disease

MalaCards integrated aliases for Leukocyte Disease:

Name: Leukocyte Disease 12 15
Leukocyte Disorders 43 71
Abnormality of Leukocytes 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9500
ICD9CM 34 288 288.9
MeSH 43 D007960
SNOMED-CT 67 54097007
ICD10 32 D72.9
UMLS 71 C0023510

Summaries for Leukocyte Disease

Disease Ontology : 12 A hematopoietic system disease that is located in white blood cells.

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to retinal vascular disease and neutrophilia, hereditary. An important gene associated with Leukocyte Disease is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage Response. The drugs Prednisone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include white blood cells, bone and bone marrow.

Wikipedia : 74 White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that... more...

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 retinal vascular disease 30.6 MIR21 MIR20A MIR199A1 MIR126 H2AC18
2 neutrophilia, hereditary 11.0
3 bacterial infectious disease 10.9 MIR155 ICOSLG H2AC18 CCR6
4 combined t cell and b cell immunodeficiency 10.8 IRF4 ICOSLG H2AC18 CCR6
5 collagen disease 10.8 MIR21 MIR142 ICOSLG H2AC18 CCR6
6 spinal cord disease 10.8 MIR142 ICOSLG H2AC18 CCR6
7 thymus gland disease 10.8 MIR125A ICOSLG H2AC18 CCR6
8 hypersensitivity reaction type iv disease 10.8 MIR155 ICOSLG H2AC18 CCR6
9 extrinsic cardiomyopathy 10.8 MIR21 ICOSLG H2AC18 CCR6
10 autoimmune disease of endocrine system 10.8 MIR125A ICOSLG H2AC18 CCR6
11 thymus cancer 10.8 MIR125A ICOSLG H2AC18 CCR6
12 x-linked recessive disease 10.8 U2AF1 MIR142 ICOSLG H2AC18 CCR6
13 hypotrichosis 1 10.8 KDM4C ICOSLG H2AC18 CCR6
14 parasitic helminthiasis infectious disease 10.8 MIR21 ICOSLG H2AC18 CCR6
15 hypotrichosis 10.8 KDM4C ICOSLG H2AC18 CCR6
16 monoclonal gammopathy of uncertain significance 10.8 U2AF1 MIR126 ICOSLG CCR6
17 primary bacterial infectious disease 10.8 MIR21 MIR155 MIR125A ICOSLG H2AC18 CCR6
18 marginal zone b-cell lymphoma 10.8 U2AF1 MIR9-1 MIR142 KDM4C IRF4 CCR6
19 bacterial pneumonia 10.8 MIR155 ICOSLG H2AC18 CCR6
20 testicular disease 10.8 MIR199A1 MIR181A1 KDM4C H2AC18 CCR6
21 autosomal recessive disease 10.8 U2AF1 MIR9-1 MIR17 IRF4 H2AC18 CCR6
22 primary mediastinal b-cell lymphoma 10.8 MIR9-1 MIR181A1 MIR155 KDM4C
23 lymphatic system disease 10.8 U2AF1 MIR17 MIR125A KDM4C IRF4 ICOSLG
24 hair disease 10.8 KDM4C ICOSLG H2AC18 CCR6
25 blood coagulation disease 10.8 U2AF1 ICOSLG H2AC18 CCR6
26 x-linked monogenic disease 10.8 U2AF1 MIR9-1 MIR142 ICOSLG H2AC18 CCR6
27 central nervous system hematologic cancer 10.8 MIR199A1 MIR18A KDM4C IRF4
28 ovary epithelial cancer 10.8 U2AF1 MIR21 MIR199A1 MIR17 MIR125A KDM4C
29 rheumatic disease 10.8 MIR155 MIR142 ICOSLG H2AC18 CCR6
30 systemic scleroderma 10.8 MIR21 MIR142 ICOSLG H2AC18 CCR6
31 cervix carcinoma 10.8 U2AF1 MIR199A1 MIR155 MIR142 H2AC18
32 lymphatic system cancer 10.8 MIR17 MIR142 MIR126 KDM4C IRF4 ICOSLG
33 mycobacterium tuberculosis 1 10.8 MIR21 MIR155 ICOSLG H2AC18 CCR6
34 heart conduction disease 10.8 MIR21 MIR199A1 MIR142 MIR126 H2AC18
35 peripheral nervous system disease 10.8 MIR21 MIR142 MIR126 ICOSLG H2AC18 CCR6
36 bronchial disease 10.8 MIR21 MIR17 MIR155 MIR142 MIR126 ICOSLG
37 facioscapulohumeral muscular dystrophy 1 10.8 MIR34A MIR21 MIR155 KDM4C H2AC18
38 uveal disease 10.8 U2AF1 MIR9-1 MIR199A1 MIR142 ICOSLG H2AC18
39 ovarian serous carcinoma 10.8 MIR21 MIR20A MIR199A1 MIR125A
40 feingold syndrome 1 10.8 MIR92A1 MIR20A MIR18A MIR17
41 laryngeal disease 10.8 MIR34A MIR21 MIR20A MIR17 MIR142 H2AC18
42 intrinsic cardiomyopathy 10.8 MIR21 MIR199A1 MIR142 MIR126 ICOSLG H2AC18
43 tongue disease 10.8 MIR21 MIR199A1 MIR18A MIR181A1 MIR17 CCR6
44 contractures, pterygia, and variable skeletal fusions syndrome 1a 10.8 U2AF1 MIR9-1 MIR199A1 MIR17 KDM4C H2AC18
45 thyroid gland papillary carcinoma 10.8 MIR9-1 MIR199A1 MIR181A1 MIR17 MIR125A
46 muscle tissue disease 10.8 U2AF1 MIR9-1 MIR199A1 MIR142 ICOSLG H2AC18
47 chromosomal deletion syndrome 10.8 MIR9-1 MIR17 MIR142 H2AC18
48 malignant ovarian surface epithelial-stromal neoplasm 10.8 MIR21 MIR199A1 MIR17 MIR125A KDM4C ICOSLG
49 pervasive developmental disorder 10.8 U2AF1 MIR9-1 MIR142 KDM4C H2AC18 CCR6
50 colonic benign neoplasm 10.8 MIR20A MIR18A MIR15A KDM4C H2AC18 CCR6

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:



Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

Drugs & Therapeutics for Leukocyte Disease

Drugs for Leukocyte Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2 Anti-Inflammatory Agents Phase 4
3 Hormone Antagonists Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 glucocorticoids Phase 4
6 Hormones Phase 4
7 Benralizumab Approved, Investigational Phase 2, Phase 3 1044511-01-4
8 Respiratory System Agents Phase 2, Phase 3
9 Anti-Asthmatic Agents Phase 2, Phase 3
10 Pharmaceutical Solutions Phase 2, Phase 3
11 Immunoglobulins Phase 2, Phase 3
12 Antibodies Phase 2, Phase 3
13
Histidine Investigational, Nutraceutical Phase 2, Phase 3 71-00-1 6274
14
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
15
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
16 BB 1101

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes Recruiting NCT01524536 Phase 4 prednisone
2 A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Subcutaneous Benralizumab (MEDI-563) in Reducing Eosinophilia in Subjects With Hypereosinophilic Syndrome (HES) Active, not recruiting NCT02130882 Phase 2, Phase 3 benralizumab
3 Cognitive Function in Leukocyte Disorders Completed NCT00005933
4 Effects of CPB-leukocyte Filtration on Interleukins Serum Levels and Pulmonary Function. Completed NCT01469676
5 Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent Completed NCT00059423
6 Research Respiratory Tract Procedures Recruiting NCT00471250
7 Investigation of the Genetics of Hematologic Diseases Recruiting NCT02720679
8 An Expanded Access Study of the Feasibility of Using the CliniMACS® Device for CD34+ Cell Selection and T Cell Depletion for Graft-versus-Host Disease Prophylaxis in Alternative Donor Stem Cell Transplant Recipients Available NCT01200017

Search NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

# Genetic test Affiliating Genes
1 Abnormality of Leukocytes 29

Anatomical Context for Leukocyte Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Leukocyte Disease:

19
White Blood Cells

MalaCards organs/tissues related to Leukocyte Disease:

40
Bone, Bone Marrow, B Cells, Thyroid, T Cells, Heart, Skin

Publications for Leukocyte Disease

Articles related to Leukocyte Disease:

(show all 13)
# Title Authors PMID Year
1
External validation of leukocytosis and neutrophilia as a prognostic marker in anal carcinoma treated with definitive chemoradiation. 61
28662871 2017
2
[Detection and initial management of the systemic inflammatory response syndrome in medicine emergency room: 24 hours follow-up in a general hospital]. 61
18769740 2008
3
Leukocyte disorders: quantitative and qualitative disorders of the neutrophil, part 2. 61
8775892 1996
4
Leukocyte disorders: quantitative and qualitative disorders of the neutrophil, Part 1. 61
8559712 1996
5
Leukocyte function and nonmalignant leukocyte disorders. 61
8374630 1993
6
Levels of human serum granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor under pathological conditions. 61
1377927 1992
7
Training and practice activities of hematology and medical oncology diplomates. 61
2297285 1990
8
Diagnosis of leukocyte disorders with an automated haematology counter (Technicon H-1 analyser). 61
2802504 1989
9
Retinal blood velocity in patients with leukocyte disorders. 61
3190539 1988
10
Influence of underlying disease process on the utility of cellulitis needle aspirates. 61
3190376 1988
11
[Leukocyte disorders in neonatal septicemia]. 61
3653612 1986
12
The local inflammatory response in leukocyte disorders. 61
121576 1979
13
Functional leukocyte disorders. 61
471548 1979

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.93 MIR92A1 MIR9-1 MIR34A MIR21 MIR20A MIR199A1
2
Show member pathways
11.92 MIR92A1 MIR20A MIR18A MIR181A1 MIR17
3 11.18 MIR92A1 MIR20A MIR18A MIR17
4 11.01 MIR9-1 MIR199A1 MIR181A1

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 MIR92A1 MIR21 MIR20A MIR199A1 MIR18A MIR181A1

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 KDM4C MIR125A MIR155 MIR21 MIR34A MIR92A1
2 negative regulation of gene expression GO:0010629 9.91 MIR125A MIR155 MIR17 MIR181A1 MIR20A MIR21
3 positive regulation of angiogenesis GO:0045766 9.9 MIR126 MIR199A1 MIR20A MIR21
4 cellular response to hypoxia GO:0071456 9.88 MIR126 MIR155 MIR17 MIR34A
5 positive regulation of inflammatory response GO:0050729 9.84 MIR126 MIR155 MIR21 MIR92A1
6 negative regulation of angiogenesis GO:0016525 9.83 MIR125A MIR15A MIR21 MIR34A MIR92A1
7 negative regulation of inflammatory response GO:0050728 9.8 MIR126 MIR155 MIR15A MIR181A1 MIR20A MIR92A1
8 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.79 MIR17 MIR20A MIR21
9 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.78 MIR155 MIR15A MIR20A
10 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.77 MIR199A1 MIR20A MIR21
11 positive regulation of activated T cell proliferation GO:0042104 9.73 ICOSLG MIR155 MIR21
12 positive regulation of sprouting angiogenesis GO:1903672 9.71 MIR125A MIR126 MIR155 MIR92A1
13 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.7 MIR15A MIR21 MIR34A
14 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.69 MIR155 MIR17 MIR199A1
15 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.67 MIR155 MIR17 MIR92A1
16 negative regulation of JAK-STAT cascade GO:0046426 9.66 MIR9-1 MIR155
17 negative regulation of innate immune response GO:0045824 9.65 MIR21 MIR155
18 negative regulation of toll-like receptor signaling pathway GO:0034122 9.65 MIR17 IRF4
19 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.65 MIR21 MIR181A1
20 positive regulation of connective tissue replacement GO:1905205 9.65 MIR155 MIR199A1 MIR34A
21 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 MIR92A1 MIR21
22 positive regulation of microglial cell activation GO:1903980 9.64 MIR155 MIR142
23 positive regulation of necrotic cell death GO:0010940 9.63 MIR92A1 MIR155
24 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.63 MIR21 MIR92A1
25 positive regulation of metalloendopeptidase activity GO:1904685 9.63 MIR17 MIR21 MIR92A1
26 negative regulation of regulatory T cell differentiation GO:0045590 9.62 MIR155 MIR21
27 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.62 MIR17 MIR21
28 negative regulation of vascular wound healing GO:0061044 9.58 MIR155 MIR34A
29 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.57 MIR17 MIR20A
30 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.56 MIR155 MIR17 MIR199A1 MIR20A
31 miRNA mediated inhibition of translation GO:0035278 9.56 MIR155 MIR15A MIR17 MIR181A1 MIR20A MIR21
32 negative regulation of sprouting angiogenesis GO:1903671 9.55 MIR17 MIR18A MIR20A MIR34A MIR92A1
33 gene silencing by miRNA GO:0035195 9.44 MIR125A MIR126 MIR155 MIR15A MIR17 MIR181A1

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.44 MIR92A1 MIR9-1 MIR34A MIR21 MIR20A MIR199A1
2 RNA polymerase II complex binding GO:0000993 9.13 MIR20A MIR126 MIR125A

Sources for Leukocyte Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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