MCID: LKC003
MIFTS: 46

Leukocyte Disease

Categories: Blood diseases

Aliases & Classifications for Leukocyte Disease

MalaCards integrated aliases for Leukocyte Disease:

Name: Leukocyte Disease 12 15
Leukocyte Disorders 44 73
Abnormality of Leukocytes 29

Classifications:



External Ids:

Disease Ontology 12 DOID:9500
ICD10 33 D72.9
ICD9CM 35 288 288.9
MeSH 44 D007960
UMLS 73 C0023510

Summaries for Leukocyte Disease

MalaCards based summary : Leukocyte Disease, also known as leukocyte disorders, is related to pdgfra-associated chronic eosinophilic leukemia and cytokine deficiency. An important gene associated with Leukocyte Disease is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Tazobactam and Cilastatin have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone and bone marrow, and related phenotypes are hematopoietic system and immune system

Related Diseases for Leukocyte Disease

Diseases related to Leukocyte Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 pdgfra-associated chronic eosinophilic leukemia 11.1 FIP1L1 PDGFRA
2 cytokine deficiency 11.1 IL13 IL5
3 primary hypereosinophilic syndrome 11.1 FIP1L1 PDGFRA
4 pemphigoid gestationis 11.0 CCL11 IL5
5 seborrheic infantile dermatitis 11.0 CSF2 IL3 IL5
6 reticular perineurioma 11.0 KIT PDGFRA
7 strongyloidiasis 11.0 CCL11 IL13 IL5
8 angioimmunoblastic lymphadenopathy with dysproteinemia 11.0 IL13 IL5
9 folliculitis 11.0 CCL11 IL4 IL5
10 sm-ahnmd 11.0 FIP1L1 KIT PDGFRA
11 apple allergy 11.0 IL13 IL4 IL5
12 endomyocardial fibrosis 11.0 FIP1L1 IL4 PDGFRA
13 esophagitis, eosinophilic, 1 11.0 CCL11 IL13 IL5
14 gallbladder leiomyoma 11.0 CD34 KIT
15 lung leiomyosarcoma 11.0 CD34 KIT
16 cough variant asthma 11.0 IL4 IL5 RNASE3
17 chronic eosinophilic pneumonia 11.0 CCL11 IL5 RNASE3
18 night blindness, congenital stationary, type 1a 11.0 CCL11 IL13 IL5
19 paragonimiasis 11.0 IL13 IL5 RNASE3
20 maxillary sinus adenoid cystic carcinoma 11.0 IL2 KIT
21 chronic eosinophilic leukemia 11.0 FIP1L1 KIT PDGFRA
22 blepharoconjunctivitis 10.9 CCL11 IL4 RNASE3
23 trichinosis 10.9 CD40LG IL4 IL5
24 chronic interstitial cystitis 10.9 CD40LG RNASE3
25 enterobiasis 10.9 IL13 IL4 IL5
26 giant papillary conjunctivitis 10.9 CCL11 IL4 RNASE3
27 paranasal sinus disease 10.9 IL13 IL4 IL5
28 liver leiomyoma 10.9 CD34 KIT
29 virus associated hemophagocytic syndrome 10.9 IL2 IL4
30 milk allergy 10.9 IL4 IL5 RNASE3
31 lichen disease 10.9 CD40LG IL4 TLR9
32 vasomotor rhinitis 10.9 CD40LG RNASE3 TLR9
33 systemic mastocytosis 10.9 FIP1L1 KIT PDGFRA
34 esophagitis 10.9 CCL11 IL13 IL5
35 extrinsic cardiomyopathy 10.9 CD40LG IL4 TLR9
36 opportunistic mycosis 10.9 CD40LG IL4 TLR9
37 zygomycosis 10.9 CSF3 ELANE
38 churg-strauss syndrome 10.9 CD40LG IL5 RNASE3
39 filariasis 10.9 IL2 IL5 TLR9
40 deep leiomyoma 10.9 CD34 KIT
41 dermatitis herpetiformis 10.9 CCL11 CD40LG IL4
42 paracoccidioidomycosis 10.9 IL2 IL4 IL5
43 myeloproliferative neoplasm 10.9 FIP1L1 KIT PDGFRA
44 wells syndrome 10.9 IL2 IL5 RNASE3
45 chronic tic disorder 10.8 CSF2 IL13 IL4 IL5
46 extracutaneous mastocytoma 10.8 CD34 KIT
47 tonsillitis 10.8 IL2 IL4 TLR9
48 status asthmaticus 10.8 ELANE IL5 RNASE3
49 cutaneous leishmaniasis 10.8 IL13 IL4 IL5 TLR9
50 hypersensitivity reaction type iv disease 10.8 CD40LG IL2 TLR9

Comorbidity relations with Leukocyte Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease

Graphical network of the top 20 diseases related to Leukocyte Disease:



Diseases related to Leukocyte Disease

Symptoms & Phenotypes for Leukocyte Disease

MGI Mouse Phenotypes related to Leukocyte Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 ELANE G6PC3 CSF2 HAX1 IL13 CCL11
2 immune system MP:0005387 10.31 ELANE G6PC3 CSF2 HAX1 IL13 CCL11
3 cellular MP:0005384 10.25 CD40LG HAX1 CSF2 CD34 CSF3R KIT
4 homeostasis/metabolism MP:0005376 10.21 ELANE CD40LG G6PC3 CSF2 CD34 IL2
5 endocrine/exocrine gland MP:0005379 10.18 CD40LG G6PC3 CSF2 HAX1 CSF3R IL4
6 mortality/aging MP:0010768 10.13 CD40LG ELANE G6PC3 CSF2 HAX1 CSF3R
7 digestive/alimentary MP:0005381 10.04 IL2 KIT IL4 IL5 IL13 PDGFRA
8 integument MP:0010771 9.97 CD40LG CSF2 CSF3 CD34 KIT IL4
9 neoplasm MP:0002006 9.8 ELANE CSF2 CD34 KIT IL2 PDGFRA
10 renal/urinary system MP:0005367 9.7 CD40LG CSF2 CSF3 KIT IL4 PDGFRA
11 reproductive system MP:0005389 9.61 CD40LG CSF2 CSF3R KIT IL2 IL4
12 respiratory system MP:0005388 9.23 CSF2 CCL11 KIT IL2 IL4 PDGFRA

Drugs & Therapeutics for Leukocyte Disease

Drugs for Leukocyte Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 473)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
2
Cilastatin Approved, Investigational Phase 4,Not Applicable 82009-34-5 5280454 6435415
3
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
5
Menthol Approved Phase 4 2216-51-5 16666
6
Cisplatin Approved Phase 4,Phase 3,Phase 2 15663-27-1 84093 441203 2767
7
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 85721-33-1 2764
8
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7 64778 441130
9
Methotrexate Approved Phase 4,Phase 3,Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
10
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
11
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
12
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
13
Imipenem Approved Phase 4,Not Applicable 74431-23-5, 64221-86-9 104838
14
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
15
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
16
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
17
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 441141 14969
18
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
19
Micafungin Approved, Investigational Phase 4,Phase 2,Phase 1 235114-32-6 3081921 477468
20
Docetaxel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 114977-28-5 148124
21
Ceftazidime Approved Phase 4,Phase 3,Phase 2 78439-06-2, 72558-82-8 5481173
22
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 53-03-2 5865
23
Fluticasone Approved, Experimental, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 90566-53-3 62924
24
Lansoprazole Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 103577-45-3 3883
25
Gemcitabine Approved Phase 4,Phase 2 95058-81-4 60750
26
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
27
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 1 242138-07-4
28
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
29
Teicoplanin Approved, Investigational Phase 4 61036-62-2
30
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
31
Penicillin G Approved, Vet_approved Phase 4 61-33-6 5904
32
Budesonide Approved Phase 4,Phase 3,Phase 2,Not Applicable 51333-22-3 63006 5281004
33
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
34
Vincristine Approved, Investigational Phase 4,Phase 2 2068-78-2, 57-22-7 5978
35
Tobramycin Approved, Investigational Phase 4,Phase 3 32986-56-4 5496 36294
36
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
37
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 1 61825-94-3 5310940 9887054 43805 6857599
38
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
39
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
40
Dexlansoprazole Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 138530-94-6, 103577-45-3 9578005
41
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 56420-45-2 41867
42
Abatacept Approved Phase 4,Phase 1 332348-12-6 10237
43
Ribavirin Approved Phase 4 36791-04-5 37542
44
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
45
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
46
Nicotinamide Approved, Investigational, Nutraceutical Phase 4,Phase 1 98-92-0 936
47
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 1 59-67-6 938
48
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
49 triamcinolone acetonide Phase 4,Phase 2,Phase 3,Phase 1
50
Hydroxyitraconazole Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 657)
# Name Status NCT ID Phase Drugs
1 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Unknown status NCT02967341 Phase 4
2 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Unknown status NCT02621905 Phase 4 Sporanox;Lozanoc
3 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
4 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
5 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
6 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
7 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
8 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
9 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
10 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
11 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
12 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
13 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
14 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
15 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
16 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Completed NCT02371941 Phase 4 oral cromolyn sodium;Placebo
17 Omalizumab to Mepolizumab Switch Study in Severe Eosinophilic Asthma Patients Completed NCT02654145 Phase 4 Mepolizumab 100mg SC;Albuterol/salbutamol MDIs;Omalizumab
18 Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis Completed NCT01846962 Phase 4 Budesonide;Fluticasone;Oral Viscous Budesonide (OVB)
19 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
20 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
21 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
22 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
23 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
24 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
25 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
26 The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia Completed NCT00632554 Phase 4 prednisolone 0.5 mg/kg/day for three months;prednisolone 0.5 mg/kg/day for six months
27 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
28 A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood Completed NCT00001317 Phase 4 interferon-gamma
29 Steroid Treatment for Hypereosinophilic Syndrome Recruiting NCT01524536 Phase 4 Corticosteroids
30 Granulocyte-colony Stimulating Factors or Antibiotics for Primary Prophylaxis for Febrile Neutropenia Recruiting NCT02816112 Phase 4 Ciprofloxacin;Neupogen
31 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Recruiting NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
32 A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile Neutropenia Recruiting NCT02816164 Phase 4 Neupogen
33 Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis Active, not recruiting NCT02019758 Phase 4 Oral Viscous Budesonide;Fluticasone MDI;Placebo slurry;Placebo inhaler
34 To Evaluate the Efficacy and Safety of PEG-rhG-CSF(Jinyouli®) in Reducing Neutropenia in Patients With Cervical Cancer Not yet recruiting NCT03206684 Phase 4 PEG-rhG-CSF;rhG-CSF
35 Immunogenicity, Safety, and Efficacy of Zarzio®/Filgrastim HEXAL® in Patients With Severe Chronic Neutropenia Terminated NCT01859637 Phase 4
36 SubCutaneous (SC) Versus Intravenous (IV) Granulocyte Colony Stimulating Factors (G-CSF) for the Treatment of Neutropenia in Hospitalized Haemato-oncological Patients Terminated NCT01222819 Phase 4 filgrastim
37 Ambisome and Management of Culture-negative Neutropenic Fever Unresponsive to Antibiotics Terminated NCT00421187 Phase 4 Liposomal amphotericin B (AmBisome®);Liposomal amphotericin B (AmBisome®)
38 Comparison of 2 Antifungal Treatment (Empirical Versus Pre-Empirical) Strategies in Prolonged Neutropenia Terminated NCT00190463 Phase 4 Amphotericin B
39 The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors Terminated NCT01404832 Phase 4 Treat with lansoprazole 30 mg BID for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms
40 Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease Terminated NCT01147042 Phase 4 IFN-gamma
41 Treatment of Anemia and Neutropenia in HIV/HCV Coinfected Patients Treated With Pegylated Interferon and Ribavirin Terminated NCT00194857 Phase 4 erythropoietin, GCSF
42 Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid Arthritis Withdrawn NCT01717846 Phase 4 Group 1 or Orencia treated group
43 Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia Unknown status NCT00002658 Phase 3 amsacrine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;idarubicin;mitoxantrone hydrochloride;thioguanine;tretinoin
44 Eosinophilic Esophagitis (EoE) Intervention Trial-Randomized 1 Food Elimination vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids Unknown status NCT02610816 Phase 2, Phase 3 Flovent (fluticasone propionate)
45 Pegfilgrastim on Day +3 Compared to Day +1 After Salvage Chemotherapy for Patients With Refractory or Relapsed Aggressive Lymphoma Unknown status NCT02238873 Phase 3 Pegfilgrastim
46 Eosinophilic Esophagitis Treatment: Montelukast vs Fluticasone Unknown status NCT01702701 Phase 3 Montelukast;Fluticasone
47 A Study of Pegylated rhG-CSF as Support to Advanced Non-Small-Cell Lung Cancer (NSCLC) Patients Receiving Chemotherapy Receiving Chemotherapy Unknown status NCT01560195 Phase 3 Pegylated rhG-CSF: 100µg/kg;Pegylated rhG-CSF: 6mg;placebo and rhG-CSF 5ug/kg/d
48 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
49 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
50 Safety and Efficacy Study of Posaconazole vs. Fluconazole for Prevention of Invasive Fungal Infection (P05387 AM1)(COMPLETED) Completed NCT00811928 Phase 3 Posaconazole;Fluconazole

Search NIH Clinical Center for Leukocyte Disease

Cochrane evidence based reviews: leukocyte disorders

Genetic Tests for Leukocyte Disease

Genetic tests related to Leukocyte Disease:

# Genetic test Affiliating Genes
1 Abnormality of Leukocytes 29

Anatomical Context for Leukocyte Disease

MalaCards organs/tissues related to Leukocyte Disease:

41
Myeloid, Bone, Bone Marrow, Testes, B Cells, T Cells, Lung

Publications for Leukocyte Disease

Variations for Leukocyte Disease

Expression for Leukocyte Disease

Search GEO for disease gene expression data for Leukocyte Disease.

Pathways for Leukocyte Disease

Pathways related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2
Show member pathways
13.87 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
3
Show member pathways
13.71 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
4
Show member pathways
13.5 CCL11 IL13 IL2 IL3 IL4 IL5
5
Show member pathways
13.32 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
6
Show member pathways
13.28 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
7
Show member pathways
13.21 CCL11 CD40LG CSF2 CSF3 CSF3R IL13
8
Show member pathways
13.03 CSF3 CSF3R G6PC3 IL2 IL3 IL4
9
Show member pathways
12.92 CCL11 CD40LG IL13 IL2 IL3 IL4
10 12.87 CSF3R IL13 IL2 IL3 IL4 IL5
11 12.62 CD34 CD40LG IL2 IL3 IL4 KIT
12
Show member pathways
12.58 CSF2 IL13 IL3 IL4 IL5
13
Show member pathways
12.51 CSF2 CSF3 CSF3R IL13 IL2 IL3
14
Show member pathways
12.44 CD40LG CSF2 IL2 IL4 IL5
15
Show member pathways
12.4 IL13 IL2 IL5 PDGFRA
16
Show member pathways
12.4 IL13 IL2 IL4 IL5
17
Show member pathways
12.39 CCL11 CSF2 CSF3 IL13 IL4 IL5
18
Show member pathways
12.14 CSF2 IL2 IL3 IL5
19
Show member pathways
12.12 CCL11 IL13 IL2 IL3 IL4 IL5
20
Show member pathways
12.04 IL13 IL2 IL5 TLR9
21 11.89 CSF2 IL13 IL2 IL4 IL5
22 11.86 CD34 IL13 IL2 IL4 IL5 KIT
23
Show member pathways
11.81 CD40LG CSF2 IL2 IL3 IL4 IL5
24 11.8 CD34 CSF2 IL2 KIT TLR9
25 11.74 CD34 ELANE KIT
26 11.74 CD34 CSF2 CSF3 CSF3R IL3 IL4
27 11.72 CCL11 CD40LG IL4 IL5
28 11.68 CCL11 CSF2 CSF3 IL13 IL4 IL5
29
Show member pathways
11.64 CD40LG CSF2 IL2
30 11.61 CSF2 CSF3 IL13 IL4
31 11.59 CSF2 CSF3 IL3 IL5
32 11.57 CD34 CD40LG KIT
33 11.56 CCL11 IL13 IL2 IL4 IL5
34 11.53 CD40LG CSF3 TLR9
35 11.42 CD40LG IL2 IL4 IL5
36 11.34 CD34 CSF2 CSF3 CSF3R IL2 IL3
37 11.32 IL13 IL4 IL5
38 11.28 IL13 IL2 IL4 IL5
39 10.98 CSF2 CSF3 IL13 IL2 IL3 IL4

GO Terms for Leukocyte Disease

Cellular components related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL11 CD34 CD40LG CSF2 CSF3 CSF3R
2 external side of plasma membrane GO:0009897 9.55 CD34 CD40LG IL13 KIT PDGFRA
3 extracellular space GO:0005615 9.44 CCL11 CD40LG CSF2 CSF3 ELANE IL13

Biological processes related to Leukocyte Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 CCL11 CD40LG IL13 IL5 KIT TLR9
2 positive regulation of cell proliferation GO:0008284 9.95 CSF2 CSF3 IL2 IL3 IL5 KIT
3 positive regulation of protein kinase B signaling GO:0051897 9.87 CSF3 HAX1 KIT PDGFRA
4 MAPK cascade GO:0000165 9.85 CSF2 IL2 IL3 IL5 KIT PDGFRA
5 peptidyl-tyrosine phosphorylation GO:0018108 9.83 CSF2 IL3 IL5 KIT PDGFRA
6 immune response GO:0006955 9.81 CCL11 CD40LG CSF2 CSF3 IL13 IL2
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 CSF3 HAX1 IL3 IL5
8 positive regulation of T cell proliferation GO:0042102 9.78 CD40LG IL2 IL4
9 negative regulation of neuron death GO:1901215 9.77 CD34 CSF3 IL13
10 cellular response to cytokine stimulus GO:0071345 9.76 CSF3 HAX1 IL13
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 CSF3 HAX1 KIT PDGFRA
12 positive regulation of DNA replication GO:0045740 9.73 CSF2 IL3 PDGFRA
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 CSF2 IL13 IL2 IL3 KIT
14 positive regulation of interleukin-10 production GO:0032733 9.69 CD34 CD40LG TLR9
15 positive regulation of B cell proliferation GO:0030890 9.65 IL13 IL2 IL4 IL5 TLR9
16 dendritic cell differentiation GO:0097028 9.64 CSF2 IL4
17 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL5
18 positive regulation of podosome assembly GO:0071803 9.63 CSF2 IL5
19 regulation of myeloid cell differentiation GO:0045637 9.62 CSF2 CSF3R
20 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IL2 IL4
21 positive regulation of phospholipase C activity GO:0010863 9.61 KIT PDGFRA
22 regulation of signaling receptor activity GO:0010469 9.61 CCL11 CD40LG CSF2 CSF3 IL13 IL2
23 positive regulation of immunoglobulin production GO:0002639 9.6 IL13 TLR9
24 mast cell chemotaxis GO:0002551 9.58 CCL11 KIT
25 neutrophil differentiation GO:0030223 9.55 CSF2 CSF3
26 negative regulation of complement-dependent cytotoxicity GO:1903660 9.52 IL13 IL4
27 cytokine-mediated signaling pathway GO:0019221 9.32 CCL11 CSF2 CSF3 CSF3R IL13 IL2
28 negative regulation of apoptotic process GO:0043066 10.01 CD40LG HAX1 IL2 IL4 KIT PDGFRA

Molecular functions related to Leukocyte Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.65 CSF2 IL3 IL5 KIT PDGFRA
2 growth factor activity GO:0008083 9.63 CSF2 CSF3 IL2 IL3 IL4 IL5
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.43 CSF2 IL2 IL3 IL5 KIT PDGFRA
4 cytokine activity GO:0005125 9.28 CCL11 CD40LG CSF2 CSF3 IL13 IL2

Sources for Leukocyte Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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