Aliases & Classifications for Leukomalacia

MalaCards integrated aliases for Leukomalacia:

Name: Leukomalacia 53

Classifications:



Summaries for Leukomalacia

MalaCards based summary : Leukomalacia is related to periventricular leukomalacia and cerebral palsy. An important gene associated with Leukomalacia is MCOLN1 (Mucolipin 1), and among its related pathways/superpathways are Hematopoietic cell lineage and Amoebiasis. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and cervix, and related phenotypes are integument and muscle

Related Diseases for Leukomalacia

Diseases related to Leukomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 periventricular leukomalacia 32.1 IL6 MCOLN1 RPS6KC1 TNF
2 cerebral palsy 30.5 IL6 TNF
3 cytomegalovirus infection 30.1 IL6 TNF
4 listeriosis 29.8 IL6 TNF
5 perinatal necrotizing enterocolitis 29.8 IL6 TNF
6 appendicitis 29.7 IL6 TNF
7 fetal indomethacin syndrome 11.0
8 cerebritis 10.4
9 autoimmune myocarditis 10.4 SPP1 TNF
10 carotid stenosis 10.3 SPP1 TNF
11 scorpion envenomation 10.3 IL6 TNF
12 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
13 critical limb ischemia 10.2 IL6 TNF
14 streptococcal toxic-shock syndrome 10.2 IL6 TNF
15 null-cell leukemia 10.2 IL6 TNF
16 retinitis pigmentosa 55 10.2 IL6 TNF
17 anca-associated vasculitis 10.2 IL6 TNF
18 laryngitis 10.2 IL6 TNF
19 acute vascular insufficiency of intestine 10.2 IL6 TNF
20 posterior urethral valves 10.2 IL6 TNF
21 poems syndrome 10.2 IL6 TNF
22 microscopic colitis 10.2 IL6 TNF
23 meconium aspiration syndrome 10.2 IL6 TNF
24 burning mouth syndrome 10.2 IL6 TNF
25 central nervous system vasculitis 10.2 IL6 TNF
26 osteosclerotic myeloma 10.2 IL6 TNF
27 stachybotrys chartarum 10.2 IL6 TNF
28 louse-borne relapsing fever 10.2 IL6 TNF
29 transverse myelitis 10.2 IL6 TNF
30 ischemic heart disease 10.2 IL6 TNF
31 crimean-congo hemorrhagic fever 10.2 IL6 TNF
32 intermediate uveitis 10.2 IL6 TNF
33 monoclonal gammopathy of uncertain significance 10.2 IL6 TNF
34 post-transplant lymphoproliferative disease 10.2 IL6 TNF
35 eales disease 10.2 IL6 TNF
36 hemorrhagic fever 10.2 IL6 TNF
37 myelitis 10.2 IL6 TNF
38 stromal keratitis 10.2 IL6 TNF
39 hematopoietic stem cell transplantation 10.2 IL6 TNF
40 endometritis 10.2 IL6 TNF
41 rosacea 10.2 IL6 TNF
42 systolic heart failure 10.2 IL6 TNF
43 joint disorders 10.2 IL6 TNF
44 pulpitis 10.2 IL6 TNF
45 localized scleroderma 10.2 IL6 TNF
46 plasmodium vivax malaria 10.2 IL6 TNF
47 apnea, obstructive sleep 10.2 IL6 TNF
48 commensal bacterial infectious disease 10.2 IL6 TNF
49 lacrimal apparatus disease 10.2 IL6 TNF
50 adult-onset still's disease 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Leukomalacia:



Diseases related to Leukomalacia

Symptoms & Phenotypes for Leukomalacia

MGI Mouse Phenotypes related to Leukomalacia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 IL6 MCOLN1 SPP1 TNF
2 muscle MP:0005369 8.92 IL6 MCOLN1 SPP1 TNF

Drugs & Therapeutics for Leukomalacia

Drugs for Leukomalacia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 1 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3 7487-88-9 24083
4
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3 57-83-0 5994
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-02-2 5743
6
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
7
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 378-44-9 9782
8
Labetalol Approved Phase 4 36894-69-6 3869
9
Nifedipine Approved Phase 4 21829-25-4 4485
10
Methyldopa Approved Phase 4 555-30-6 38853
11
Indomethacin Approved, Investigational Phase 4,Phase 1,Phase 2 53-86-1 3715
12 Poractant alfa Approved Phase 4 129069-19-8
13
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
14 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 calcium channel blockers Phase 4,Phase 3
16 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
17 Central Nervous System Depressants Phase 4,Phase 3
18 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Tocolytic Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Anesthetics Phase 4,Phase 3
21 Dihydroxyphenylalanine Phase 4
22 Dopamine Agents Phase 4,Phase 3,Phase 1
23 Anti-Arrhythmia Agents Phase 4,Phase 3
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable
26 Anticonvulsants Phase 4,Phase 3
27 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Pulmonary Surfactants Phase 4,Phase 3,Phase 2,Phase 1
29 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Carbidopa, levodopa drug combination Phase 4
31 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
32 Progestins Phase 4,Phase 2,Phase 3
33 Betamethasone Valerate Phase 4,Phase 2,Phase 3,Not Applicable 2152-44-5
34 Dexamethasone acetate Phase 4,Phase 2,Phase 3,Not Applicable 1177-87-3
35 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
36
protease inhibitors Phase 4,Phase 3,Not Applicable
37 11-hydroxyprogesterone Phase 4,Phase 2,Phase 3
38 17-alpha-hydroxy-progesterone caproate Phase 4,Phase 2,Phase 3
39 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
40 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Not Applicable
41 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 HIV Protease Inhibitors Phase 4,Phase 3,Not Applicable
44 Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
45 Hormones Phase 4,Phase 2,Phase 3,Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
47 Vasodilator Agents Phase 4,Phase 3,Phase 2
48 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Not Applicable
49 Estrogen Antagonists Phase 4,Phase 2,Phase 3
50 Estrogens Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 138)
# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
3 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
4 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
5 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
6 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
7 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
8 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
9 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
10 Randomized Controlled Trial of Vaginal Progesterone in Women With Threatened Preterm Labor Terminated NCT01286246 Phase 4 Vaginal progesterone;Placebo
11 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
12 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
13 Magnesium Sulfate to Prevent Brain Injury in Premature Infants Unknown status NCT00065949 Phase 3 magnesium sulfate
14 Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation Unknown status NCT01134302 Phase 3
15 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
16 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3 Phenobarbital;Saline
17 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
18 Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia Completed NCT02059135 Phase 3
19 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3 17-alpha-hydroxyprogesterone caproate injectable;Placebo
20 Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight Completed NCT00734539 Phase 3 fluconazole;placebo
21 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
22 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Completed NCT00233324 Phase 3 Surfactant;Supplemental oxygen with target saturation of 85 to 89%;Supplemental oxygen with target saturation of 91 to 95%
23 Caffeine for Apnea of Prematurity (CAP) Completed NCT00182312 Phase 3 Caffeine citrate injection
24 Pentoxifylline and Late Onset Sepsis in Preterm Infants Completed NCT02163174 Phase 3 Pentoxifylline (PTX);Placebo
25 High Versus Low Dose of Caffeine for Apnea of Prematurity Completed NCT02103777 Phase 3 Caffeine citrate
26 Safety and Efficacy Study of Ibuprofen l-Lysine Solution in Premature Infants for Treatment of PDA Completed NCT00440804 Phase 3 ibuprofen l-lysine iv solution (NeoProfen (R) )
27 Omega-3 Fatty Acid Supplementation to Prevent Preterm Birth in High Risk Pregnancies Completed NCT00135902 Phase 3 17 alpha-Hydroxyprogesterone Caproate and Omega-3 fish oils
28 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
29 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3 17 alpha-hydroxyprogesterone caproate (17P)
30 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
31 Effect of Erythropoietin in Premature Infants on White Matter Lesions and Neurodevelopmental Outcome Recruiting NCT03110341 Phase 3 Erythropoietin;Normal saline
32 Impact of a Booster Course of Antenatal Steroids on Neonatal Outcome in Patients With Premature Rupture of the Membranes Recruiting NCT02469519 Phase 2, Phase 3 Betamethasone - ACTIVE
33 Dose Reduction of Antenatal Betamethasone Given to Prevent the Neonatal Complications Associated With Very Preterm Birth Recruiting NCT02897076 Phase 3 betamethasone 24 mg;12mg betamethasone +placebo
34 Tracheal Occlusion To Accelerate Lung Growth (TOTAL) Trial for Severe Pulmonary Hypoplasia Recruiting NCT01240057 Phase 2, Phase 3
35 Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity? Recruiting NCT02939742 Phase 2, Phase 3 Betamethasone;Placebo
36 Low-molecular-weight Heparin in Constituted Vascular Intrauterine Growth Restriction Recruiting NCT02672566 Phase 3 Enoxaparin
37 Inhaled Nitric Oxide and Neuroprotection in Premature Infants Active, not recruiting NCT00515281 Phase 2, Phase 3 inhaled nitric oxide;oxygen
38 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Active, not recruiting NCT02371460 Phase 3
39 Transfusion of Prematures Trial Active, not recruiting NCT01702805 Phase 3
40 Cervical Pessary vs Vaginal Progesterone in Preventing Preterm Birth Among Women Presenting With Short Cervix: An Open-label Randomized Controlled Trial Not yet recruiting NCT02470676 Phase 2, Phase 3 Progesterone
41 Treatment of Intrauterine Growth Restriction With Low Molecular Heparin. Not yet recruiting NCT03324139 Phase 3 Low molecular weight heparin;Placebos
42 Efficacy and Safety of Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates Not yet recruiting NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
43 Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity Terminated NCT00303082 Phase 3 Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
44 Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE) Terminated NCT00005777 Phase 3 Dexamethasone;Placebo
45 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
46 Effectiveness of ACS in Extreme Preemies Withdrawn NCT02351310 Phase 3 Betamethasone
47 Vaginal Progesterone in Twins With Short Cervix Withdrawn NCT01812239 Phase 2, Phase 3 Vaginal Progesterone gel.;Placebo gel
48 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2 recombinant human erythropoietin (rhEpo);recombinant human erythropoietin (rhEpo);Normal saline
49 Minimally Invasive Surfactant Therapy Followed by CPAP (MISTCPAP) in Preterm Infants With RDS Unknown status NCT01723683 Phase 2 Surfactant
50 Does Erythropoietin Improve Outcome in Very Preterm Infants? Completed NCT00413946 Phase 2 Recombinant human Erythropoietin;saline

Search NIH Clinical Center for Leukomalacia

Genetic Tests for Leukomalacia

Anatomical Context for Leukomalacia

MalaCards organs/tissues related to Leukomalacia:

41
Brain, Lung, Cervix, Heart, Placenta, Cortex, Pons

Publications for Leukomalacia

Articles related to Leukomalacia:

(show top 50) (show all 438)
# Title Authors Year
1
The p38I+ MAPK deletion in oligodendroglia does not attenuate myelination defects in a mouse model of periventricular leukomalacia. ( 29966722 )
2018
2
Development of postural control in infancy in cerebral palsy and cystic periventricular leukomalacia. ( 29787891 )
2018
3
Improvement by Human Oligodendrocyte Progenitor Cells of Neurobehavioral Disorders in an Experimental Model of Neonatal Periventricular Leukomalacia. ( 29978719 )
2018
4
Is hiragana decoding impaired in children with periventricular leukomalacia? ( 29908673 )
2018
5
Congenital Cytomegalovirus Infection and the Occurrence of Cystic Periventricular Leukomalacia. ( 29217314 )
2018
6
Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age. ( 29398046 )
2018
7
Cystic periventricular leukomalacia: now you see it, now you don't? ( 29576177 )
2018
8
Identifying Risk Factors Shared by Bronchopulmonary Dysplasia, Severe Retinopathy, and Cystic Periventricular Leukomalacia in Very Preterm Infants for Targeted Intervention. ( 29621770 )
2018
9
Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. ( 29436652 )
2018
10
Supramodal agnosia for oblique mirror orientation in patients with periventricular leukomalacia. ( 29655042 )
2018
11
Ophthalmic Manifestations in Children with Periventricular Leukomalacia. ( 29511949 )
2018
12
Pathophysiology of periventricular leukomalacia: What we learned from animal models. ( 29239318 )
2017
13
Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis. ( 28931047 )
2017
14
Upper Limb Function, Kinematic Analysis, and Dystonia Assessment in Children With Spastic Diplegic Cerebral Palsy and Periventricular Leukomalacia. ( 28776460 )
2017
15
Periventricular leukomalacia with -16 DS high myopia in a 2A1 months old infant: A rare case presentation. ( 29118507 )
2017
16
A model of Periventricular Leukomalacia (PVL) in neonate mice with histopathological and neurodevelopmental outcomes mimicking human PVL in neonates. ( 28406931 )
2017
17
Neuroprotective effects of human umbilical cord-derived mesenchymal stem cells on periventricular leukomalacia-like brain injury in neonatal rats. ( 29259700 )
2017
18
The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. ( 26733225 )
2016
19
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
20
Intranasal surfactant protein D as neuroprotective rescue in a neonatal rat model of periventricular leukomalacia. ( 27109442 )
2016
21
Slow pupillary light responses in infants at high risk of cerebral palsy were associated with periventricular leukomalacia and neurological outcome. ( 27468114 )
2016
22
Quality of Life of Children with Cystic Periventricular Leukomalacia - A Prospective Analysis with the Child Health Questionnaire-Parent Form 50. ( 27242979 )
2016
23
Periventricular leukomalacia in a neonatal calf. ( 27010465 )
2016
24
Isolated Cystic Periventricular Leukomalacia Differs from Cystic Periventricular Leukomalacia with Intraventricular Hemorrhage in Prevalence, Risk Factors and Outcomes in Preterm Infants. ( 27643988 )
2016
25
Diffusion-Weighted Imaging of Periventricular Leukomalacia in Very Young Children: Assessment of Peritrigonal Stripe of Restricted Diffusion. ( 28030870 )
2016
26
The whole spectrum of cystic periventricular leukomalacia of the preterm infant: results from a large consecutive case series. ( 26099229 )
2015
27
Screening Cranial Imaging at Multiple Time Points Improves Cystic Periventricular Leukomalacia Detection. ( 25730135 )
2015
28
Bioinformatics analyses combined microarray identify the differentially expressed microRNAs in periventricular leukomalacia. ( 26812286 )
2015
29
Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. ( 25585037 )
2015
30
Antenatal exposure to indomethacin increases the risk of severe intraventricular hemorrhage, necrotizing enterocolitis, and periventricular leukomalacia: a systematic review with metaanalysis. ( 25448524 )
2015
31
Impact of risk factors other than prematurity on periventricular leukomalacia. A population-based matched case control study. ( 25748489 )
2015
32
Scoring system for periventricular leukomalacia in infants with congenital heart disease. ( 25996891 )
2015
33
Two important factors affecting the transition to breastfeeding in preterm infants: corrected age and periventricular leukomalacia. ( 26265900 )
2015
34
Relationship between white matter integrity and severity of motor impairment in children with cerebral palsy caused by periventricular leukomalacia. ( 26531639 )
2015
35
Clinical study of cerebral palsy in 408 children with periventricular leukomalacia. ( 25780432 )
2015
36
Increased fetal heart rate variability in periventricular leukomalacia. ( 26338690 )
2015
37
Relation between prognosis and changes of MBP and S100B in premature infants with periventricular leukomalacia. ( 25966206 )
2015
38
Corticospinal Tract Injury Precedes Thalamic Volume Reduction in Preterm Infants with Cystic Periventricular Leukomalacia. ( 26054943 )
2015
39
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children. ( 26385973 )
2015
40
Severe cystic periventricular leukomalacia in a premature infant with capnocytophaga sepsis. ( 25452885 )
2014
41
Retinal vessel pathologies in a rat model of periventricular leukomalacia: a new model for retinopathy of prematurity? ( 25698709 )
2014
42
Latency after preterm prelabor rupture of the membranes: increased risk for periventricular leukomalacia. ( 25136457 )
2014
43
Visual Evoked Potentials in Infants with Diffuse Periventricular Leukomalacia. ( 24615931 )
2014
44
Neurodevelopmental outcomes of children with periventricular leukomalacia. ( 23727042 )
2013
45
White matter loss in a mouse model of periventricular leukomalacia is rescued by trophic factors. ( 24961618 )
2013
46
Risk factors for preoperative periventricular leukomalacia in term neonates with hypoplastic left heart syndrome are patient related. ( 23879933 )
2013
47
Diphenyleneiodonium protects preoligodendrocytes against endotoxin-activated microglial NADPH oxidase-generated peroxynitrite in a neonatal rat model of periventricular leukomalacia. ( 23174417 )
2013
48
Using the Alberta Infant Motor Scale to early identify very low-birth-weight infants with cystic periventricular leukomalacia. ( 21959127 )
2013
49
Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia. ( 22795624 )
2013
50
Diffusion tensor imaging-demonstrated differences between hemiplegic and diplegic cerebral palsy with symmetric periventricular leukomalacia. ( 22976239 )
2013

Variations for Leukomalacia

Expression for Leukomalacia

Search GEO for disease gene expression data for Leukomalacia.

Pathways for Leukomalacia

GO Terms for Leukomalacia

Cellular components related to Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic cup GO:0001891 8.62 MCOLN1 TNF

Biological processes related to Leukomalacia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.67 IL6 SPP1 TNF
2 regulation of signaling receptor activity GO:0010469 9.61 IL6 SPP1 TNF
3 inflammatory response GO:0006954 9.5 IL6 SPP1 TNF
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.48 IL6 TNF
5 response to glucocorticoid GO:0051384 9.46 IL6 TNF
6 humoral immune response GO:0006959 9.4 IL6 TNF
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.37 IL6 TNF
8 positive regulation of interleukin-6 production GO:0032755 9.26 IL6 TNF
9 negative regulation of fat cell differentiation GO:0045599 9.16 IL6 TNF
10 positive regulation of chemokine production GO:0032722 8.96 IL6 TNF
11 negative regulation of lipid storage GO:0010888 8.62 IL6 TNF

Molecular functions related to Leukomalacia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL6 SPP1 TNF

Sources for Leukomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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38 LifeMap
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44 MeSH
45 MESH via Orphanet
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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