Aliases & Classifications for Leukoregulin

MalaCards integrated aliases for Leukoregulin:

Name: Leukoregulin 57

External Ids:

OMIM 57 602994

Summaries for Leukoregulin

MalaCards based summary : Leukoregulin is related to aseptic meningitis and glioblastoma. An important gene associated with Leukoregulin is CRAT (Carnitine O-Acetyltransferase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, nk cells and lung, and related phenotypes are Reduced mammosphere formation and Synthetic lethal with MLN4924 (a NAE inhibitor)

Description from OMIM: 602994

Related Diseases for Leukoregulin

Diseases related to Leukoregulin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 10.1 CSF1 CXCL8
2 glioblastoma 10.1
3 clonorchiasis 10.1 CXCL8 TGFB1
4 toxic myocarditis 10.1 CXCL8 JUN
5 ocular cicatricial pemphigoid 10.1 CSF1 TGFB1
6 tuberculous meningitis 10.1 CXCL8 TGFB1
7 stachybotrys chartarum 10.1 CSF1 IL1A
8 prostatitis 10.1 CXCL8 TGFB1
9 scabies 10.1 CXCL8 IL1A
10 sebaceous gland disease 10.0 CXCL8 IL1A
11 radiculopathy 10.0 CXCL8 IL1A
12 malignant histiocytosis 10.0 CSF1 IL1A
13 recessive dystrophic epidermolysis bullosa 10.0 JUN TGFB1
14 pulpitis 10.0 CXCL8 IL1A
15 oral candidiasis 10.0 CXCL8 IL1A
16 pneumoconiosis 10.0 CXCL8 TGFB1
17 bullous keratopathy 10.0 CXCL8 IL1A
18 transient arthritis 10.0 IL1A TGFB1
19 epithelial basement membrane dystrophy 10.0 IL1A TGFB1
20 bacterial vaginosis 10.0 CXCL8 IL1A
21 helicobacter pylori infection 10.0 CXCL8 JUN
22 gingival disease 10.0 IL1A TGFB1
23 idiopathic neutropenia 10.0 IL1A TGFB1
24 tonsillitis 10.0 CXCL8 IL1A
25 spondylarthropathy 10.0 CSF1 PTGS2
26 aggressive periodontitis 10.0 CXCL8 IL1A
27 acute generalized exanthematous pustulosis 10.0 CXCL8 PTGS2
28 endometrial disease 10.0 CXCL8 PTGS2
29 chorioamnionitis 10.0 CXCL8 IL1A
30 pharyngitis 10.0 CXCL8 PTGS2
31 gingivitis 10.0 CXCL8 IL1A
32 alveolar periostitis 10.0 JUN PTGS2
33 contact dermatitis 10.0 CXCL8 IL1A
34 monocytic leukemia 9.9 CSF1 CXCL8 JUN
35 gastric ulcer 9.9 CXCL8 PTGS2
36 dyspepsia 9.9 CXCL8 PTGS2
37 peptic ulcer disease 9.9 CXCL8 PTGS2
38 osteomyelitis 9.9 CXCL8 IL1A
39 idiopathic interstitial pneumonia 9.9 CXCL8 TGFB1
40 oral submucous fibrosis 9.9 PTGS2 TGFB1
41 urinary tract obstruction 9.9 PTGS2 TGFB1
42 silicosis 9.9 CXCL8 IL1A TGFB1
43 interstitial lung disease 9.9 CXCL8 IL1A TGFB1
44 leishmaniasis 9.9 CXCL8 IL1A TGFB1
45 pulmonary fibrosis, idiopathic 9.9 CXCL8 IL1A TGFB1
46 chlamydia 9.9 CXCL8 IL1A
47 ureteral obstruction 9.8 PTGS2 TGFB1
48 cystitis 9.8 CXCL8 PTGS2
49 esophagitis 9.8 CXCL8 PTGS2 TGFB1
50 squamous cell carcinoma, head and neck 9.8 CXCL8 PTGS2 TGFB1

Graphical network of the top 20 diseases related to Leukoregulin:



Diseases related to Leukoregulin

Symptoms & Phenotypes for Leukoregulin

Clinical features from OMIM:

602994

GenomeRNAi Phenotypes related to Leukoregulin according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.35 CSF1 CXCL8 JUN PTGS2 TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 CXCL8 IL1A JUN TGFB1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 CXCL8 IL1A JUN TGFB1

MGI Mouse Phenotypes related to Leukoregulin:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CRAT CSF1 IL1A JUN PTGS2 TGFB1
2 integument MP:0010771 9.02 CSF1 IL1A JUN PTGS2 TGFB1

Drugs & Therapeutics for Leukoregulin

Search Clinical Trials , NIH Clinical Center for Leukoregulin

Genetic Tests for Leukoregulin

Anatomical Context for Leukoregulin

MalaCards organs/tissues related to Leukoregulin:

41
Skin, Nk Cells, Lung, Bone, Spinal Cord, Tonsil, Monocytes

Publications for Leukoregulin

Articles related to Leukoregulin:

(show all 34)
# Title Authors Year
1
Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts. ( 10600759 )
1999
2
Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions. ( 9671777 )
1998
3
Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation. ( 8798446 )
1996
4
Leukoregulin induces plasminogen activator inhibitor type 1 in human orbital fibroblasts. ( 7653518 )
1995
5
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts. ( 7864077 )
1995
6
Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells. ( 1345813 )
1992
7
Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin. ( 1372007 )
1992
8
Leukoregulin, a T cell-derived cytokine, induces IL-8 gene expression and secretion in human skin fibroblasts. Demonstration and secretion in human skin fibroblasts. Demonstration of enhanced NF-kappa B binding and NF-kappa B-driven promoter activity. ( 1401924 )
1992
9
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin. ( 1356622 )
1992
10
Leukoregulin, a T-cell derived cytokine, upregulates stromelysin-1 gene expression in human dermal fibroblasts: evidence for the role of AP-1 in transcriptional activation. ( 1429874 )
1992
11
Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin. ( 1308987 )
1992
12
Leukoregulin down-regulates type I collagen mRNA levels and promoter activity in human dermal fibroblasts, and counteracts the up-regulation elicited by transforming growth factor-beta. ( 1622385 )
1992
13
The human lymphokine leukoregulin induces cell resistance to complement-mediated lysis. ( 1500082 )
1992
14
Modulation of human dermal fibroblast extracellular matrix metabolism by the lymphokine leukoregulin. ( 1646205 )
1991
15
1990 Sir Henry Wellcome medal and prize winner. Leukoregulin: a new biotherapeutic cytokine in the search for more effective anti-viral pharmacologic agents. ( 1851546 )
1991
16
Leukoregulin, a novel cytokine enhances the anti-herpesvirus actions of acyclovir. ( 1649027 )
1991
17
Implications of leukoregulin to autologous tumor-specific human T-cell populations. ( 2395004 )
1990
18
Influence of extracellular calcium on cell permeabilization and growth regulation by the lymphokine leukoregulin. ( 2112134 )
1990
19
Loss of leukoregulin up-regulation of natural killer but not lymphokine-activated killer lymphocytotoxicity in human papillomavirus 16 DNA-immortalized cervical epithelial cells. ( 2544741 )
1989
20
Preparative isoelectric focusing in ampholine electrofocusing columns versus immobiline polyacrylamide gel for the purification of biologically active leukoregulin. ( 2729555 )
1989
21
Leukoregulin. ( 2654952 )
1989
22
Leukoregulin up-regulation of tumor cell sensitivity to natural killer and lymphokine-activated killer cell cytotoxicity. ( 2688871 )
1989
23
Activation of ion channels in tumor cells by leukoregulin, a cytostatic lymphokine. ( 2455812 )
1988
24
Leukoregulin-induced translocation of protein kinase C activity in K562 cells. ( 2850124 )
1988
25
Tumor-inhibitory antibiotic uptake facilitated by leukoregulin: a new approach to drug delivery. ( 2969053 )
1988
26
Re: Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon. ( 2433031 )
1987
27
Flow cytometric evaluation of leukoregulin as an intrinsic molecular mediator of natural killer lymphocyte cytotoxicity. ( 2448552 )
1987
28
Comparative chromatography of lectins and bioactivity recovery of the immunologic hormone leukoregulin on derivatized silica and on cross-linked agarose molecular sizing high-performance liquid chromatographic matrices. ( 3034939 )
1987
29
Analysis of a cytostatic lymphokine produced by incubation of lymphocytes with tumor cells: relationship to leukoregulin and distinction from recombinant lymphotoxin, recombinant tumor necrosis factor, and natural killer cytotoxic factor. ( 2423611 )
1986
30
Leukoregulin-increased plasma membrane permeability and associated ionic fluxes. ( 3084072 )
1986
31
Analysis of cytostatic/cytotoxic lymphokines: relationship of natural killer cytotoxic factor to recombinant lymphotoxin, recombinant tumor necrosis factor, and leukoregulin. ( 3093586 )
1986
32
Leukoregulin inhibits the growth of human glioblastoma in vitro. ( 3760159 )
1986
33
The mechanism of leukoregulin enhancement of target cell susceptibility to NK cell mediated cytotoxicity in humans. ( 3862336 )
1985
34
Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon. ( 3881174 )
1985

Variations for Leukoregulin

Expression for Leukoregulin

Search GEO for disease gene expression data for Leukoregulin.

Pathways for Leukoregulin

Pathways related to Leukoregulin according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 CSF1 CXCL8 IL1A JUN PTGS2 TGFB1
2
Show member pathways
13.6 CSF1 CXCL8 IL1A JUN PTGS2 TGFB1
3
Show member pathways
13.4 CSF1 CXCL8 IL1A JUN PTGS2 TGFB1
4
Show member pathways
13.12 CSF1 CXCL8 IL1A PTGS2 TGFB1
5
Show member pathways
13.07 CSF1 CXCL8 IL1A JUN TGFB1
6
Show member pathways
12.85 CXCL8 JUN PTGS2 TGFB1
7 12.63 CXCL8 JUN PTGS2 TGFB1
8 12.57 CSF1 IL1A JUN TGFB1
9
Show member pathways
12.41 IL1A JUN TGFB1
10
Show member pathways
12.25 IL1A JUN TGFB1
11
Show member pathways
12.16 CXCL8 JUN PTGS2
12
Show member pathways
12.13 CXCL8 IL1A JUN PTGS2
13
Show member pathways
12.1 CXCL8 IL1A JUN
14
Show member pathways
12.1 IL1A JUN PTGS2 TGFB1
15
Show member pathways
12.08 CXCL8 IL1A TGFB1
16
Show member pathways
12.04 CXCL8 IL1A JUN PTGS2
17 12.02 CXCL8 IL1A JUN
18
Show member pathways
12.01 CXCL8 JUN TGFB1
19 12 CXCL8 IL1A TGFB1
20
Show member pathways
11.89 CXCL8 IL1A JUN TGFB1
21 11.87 CSF1 IL1A JUN TGFB1
22 11.81 CSF1 JUN PTGS2
23 11.81 CXCL8 IL1A PTGS2 TGFB1
24 11.76 CXCL8 IL1A PTGS2 TGFB1
25 11.69 CXCL8 IL1A JUN TGFB1
26 11.68 CXCL8 IL1A JUN
27 11.62 CXCL8 IL1A JUN TGFB1
28
Show member pathways
11.61 CXCL8 JUN PTGS2
29 11.6 CXCL8 IL1A JUN
30 11.53 JUN TGFB1
31 11.52 CXCL8 JUN
32 11.51 CXCL8 TGFB1
33 11.47 JUN TGFB1
34 11.45 CXCL8 JUN
35
Show member pathways
11.42 CSF1 JUN
36 11.39 CXCL8 TGFB1
37 11.37 JUN TGFB1
38 11.37 CSF1 TGFB1
39 11.37 CSF1 IL1A
40
Show member pathways
11.36 CXCL8 IL1A JUN PTGS2
41 11.34 IL1A JUN
42 11.32 JUN TGFB1
43 11.22 JUN PTGS2
44 11.2 CXCL8 JUN
45 11.19 CXCL8 TGFB1
46 11.16 CXCL8 JUN PTGS2 TGFB1
47 11.12 CSF1 IL1A TGFB1
48 11.11 JUN TGFB1
49 11.05 CSF1 CXCL8 IL1A
50 10.98 CSF1 CXCL8 IL1A JUN TGFB1

GO Terms for Leukoregulin

Biological processes related to Leukoregulin according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.81 CSF1 IL1A TGFB1
2 positive regulation of cell proliferation GO:0008284 9.8 CSF1 JUN PTGS2 TGFB1
3 positive regulation of apoptotic process GO:0043065 9.79 JUN PTGS2 TGFB1
4 response to drug GO:0042493 9.77 JUN PTGS2 TGFB1
5 regulation of signaling receptor activity GO:0010469 9.76 CSF1 CXCL8 IL1A TGFB1
6 angiogenesis GO:0001525 9.73 CXCL8 JUN PTGS2
7 aging GO:0007568 9.7 JUN PTGS2 TGFB1
8 cellular response to heat GO:0034605 9.65 IL1A PTGS2
9 response to organic cyclic compound GO:0014070 9.65 JUN PTGS2 TGFB1
10 learning GO:0007612 9.64 JUN PTGS2
11 response to cytokine GO:0034097 9.64 JUN PTGS2
12 SMAD protein signal transduction GO:0060395 9.63 JUN TGFB1
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.62 JUN PTGS2
14 positive regulation of fibroblast proliferation GO:0048146 9.62 JUN TGFB1
15 positive regulation of cell division GO:0051781 9.61 IL1A TGFB1
16 negative regulation of cell cycle GO:0045786 9.6 PTGS2 TGFB1
17 positive regulation of protein secretion GO:0050714 9.58 IL1A TGFB1
18 positive regulation of protein import into nucleus GO:0042307 9.58 PTGS2 TGFB1
19 response to organic substance GO:0010033 9.58 JUN PTGS2 TGFB1
20 osteoclast differentiation GO:0030316 9.57 CSF1 TGFB1
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.55 JUN TGFB1
22 negative regulation of cell proliferation GO:0008285 9.55 CXCL8 IL1A JUN PTGS2 TGFB1
23 response to vitamin D GO:0033280 9.54 PTGS2 TGFB1
24 positive regulation of cellular protein metabolic process GO:0032270 9.51 CSF1 TGFB1
25 response to radiation GO:0009314 9.5 JUN PTGS2 TGFB1
26 positive regulation of monocyte differentiation GO:0045657 9.43 CSF1 JUN
27 positive regulation of vascular endothelial growth factor production GO:0010575 9.43 IL1A PTGS2 TGFB1
28 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.37 IL1A TGFB1
29 inflammatory response GO:0006954 9.35 CSF1 CXCL8 IL1A PTGS2 TGFB1
30 cytokine-mediated signaling pathway GO:0019221 9.02 CSF1 CXCL8 IL1A PTGS2 TGFB1

Molecular functions related to Leukoregulin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 JUN PTGS2 TGFB1
2 protein homodimerization activity GO:0042803 9.26 CSF1 JUN PTGS2 TGFB1
3 cytokine activity GO:0005125 8.92 CSF1 CXCL8 IL1A TGFB1

Sources for Leukoregulin

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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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34 ICD10 via Orphanet
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62 PubMed
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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