MCID: LKR002
MIFTS: 13

Leukoregulin

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Aliases & Classifications for Leukoregulin

MalaCards integrated aliases for Leukoregulin:

Name: Leukoregulin 57

External Ids:

OMIM® 57 602994

Summaries for Leukoregulin

MalaCards based summary: Leukoregulin is related to acute erythroid leukemia and erythroleukemia. An important gene associated with Leukoregulin is PTGS2 (Prostaglandin-Endoperoxide Synthase 2). Affiliated tissues include skin, thyroid and eye.

More information from OMIM: 602994

Related Diseases for Leukoregulin

Diseases related to Leukoregulin via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 acute erythroid leukemia 10.2
2 erythroleukemia 10.2
3 graves ophthalmopathy 10.2
4 suppressor of tumorigenicity 3 10.0
5 autoimmune disease 9.9
6 retinoblastoma 9.9
7 myeloma, multiple 9.9
8 proteasome-associated autoinflammatory syndrome 1 9.9
9 insulin-like growth factor i 9.9
10 graves disease 1 9.9
11 cervical cancer 9.9
12 graves' disease 9.9
13 squamous cell carcinoma 9.9
14 glioblastoma 9.9
15 viral infectious disease 9.9
16 cytokine deficiency 9.9
17 fetal anticonvulsant syndrome 9.9
18 argyria 9.9

Graphical network of the top 20 diseases related to Leukoregulin:



Diseases related to Leukoregulin

Symptoms & Phenotypes for Leukoregulin

Clinical features from OMIM®:

602994 (Updated 08-Dec-2022)

Drugs & Therapeutics for Leukoregulin

Search Clinical Trials, NIH Clinical Center for Leukoregulin

Genetic Tests for Leukoregulin

Anatomical Context for Leukoregulin

Organs/tissues related to Leukoregulin:

MalaCards : Skin, Thyroid, Eye

Publications for Leukoregulin

Articles related to Leukoregulin:

(show all 40)
# Title Authors PMID Year
1
Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions. 62 57
9671777 1998
2
Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation. 62 57
8798446 1996
3
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts. 62 57
7864077 1995
4
Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts. 62
10600759 1999
5
Cytokines in thyroid eye disease: potential for anticytokine therapy. 62
9623733 1998
6
Leukoregulin induces plasminogen activator inhibitor type 1 in human orbital fibroblasts. 62
7653518 1995
7
[Leukoregulin--a new possibility in the treatment of virus infections and malignant tumors]. 62
8585161 1994
8
Differential cytokine regulation of type I and type VII collagen gene expression in cultured human dermal fibroblasts. 62
8276802 1994
9
Cytokine modulation of immune defenses in cervical cancer. 62
8388555 1993
10
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin. 62
1356622 1992
11
Leukoregulin, a T cell-derived cytokine, induces IL-8 gene expression and secretion in human skin fibroblasts. Demonstration and secretion in human skin fibroblasts. Demonstration of enhanced NF-kappa B binding and NF-kappa B-driven promoter activity. 62
1401924 1992
12
Leukoregulin, a T-cell derived cytokine, upregulates stromelysin-1 gene expression in human dermal fibroblasts: evidence for the role of AP-1 in transcriptional activation. 62
1429874 1992
13
Leukoregulin down-regulates type I collagen mRNA levels and promoter activity in human dermal fibroblasts, and counteracts the up-regulation elicited by transforming growth factor-beta. 62
1622385 1992
14
Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin. 62
1372007 1992
15
The human lymphokine leukoregulin induces cell resistance to complement-mediated lysis. 62
1500082 1992
16
Cytokines as positive and negative regulators of tumor promotion and progression. 62
1322742 1992
17
Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells. 62
1345813 1992
18
Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin. 62
1308987 1992
19
Leukoregulin, a novel cytokine enhances the anti-herpesvirus actions of acyclovir. 62
1649027 1991
20
Analysis of rat natural killer cytotoxic factor (NKCF): mechanism of action and relationship to other cytotoxic/cytostatic factors. 62
2018982 1991
21
Modulation of human dermal fibroblast extracellular matrix metabolism by the lymphokine leukoregulin. 62
1646205 1991
22
1990 Sir Henry Wellcome medal and prize winner. Leukoregulin: a new biotherapeutic cytokine in the search for more effective anti-viral pharmacologic agents. 62
1851546 1991
23
Implications of leukoregulin to autologous tumor-specific human T-cell populations. 62
2395004 1990
24
Influence of extracellular calcium on cell permeabilization and growth regulation by the lymphokine leukoregulin. 62
2112134 1990
25
Loss of leukoregulin up-regulation of natural killer but not lymphokine-activated killer lymphocytotoxicity in human papillomavirus 16 DNA-immortalized cervical epithelial cells. 62
2544741 1989
26
Preparative isoelectric focusing in ampholine electrofocusing columns versus immobiline polyacrylamide gel for the purification of biologically active leukoregulin. 62
2729555 1989
27
Leukoregulin up-regulation of tumor cell sensitivity to natural killer and lymphokine-activated killer cell cytotoxicity. 62
2688871 1989
28
Leukoregulin. 62
2654952 1989
29
Leukoregulin-induced translocation of protein kinase C activity in K562 cells. 62
2850124 1988
30
Activation of ion channels in tumor cells by leukoregulin, a cytostatic lymphokine. 62
2455812 1988
31
Tumor-inhibitory antibiotic uptake facilitated by leukoregulin: a new approach to drug delivery. 62
2969053 1988
32
Comparative chromatography of lectins and bioactivity recovery of the immunologic hormone leukoregulin on derivatized silica and on cross-linked agarose molecular sizing high-performance liquid chromatographic matrices. 62
3034939 1987
33
Re: Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon. 62
2433031 1987
34
Flow cytometric evaluation of leukoregulin as an intrinsic molecular mediator of natural killer lymphocyte cytotoxicity. 62
2448552 1987
35
Analysis of cytostatic/cytotoxic lymphokines: relationship of natural killer cytotoxic factor to recombinant lymphotoxin, recombinant tumor necrosis factor, and leukoregulin. 62
3093586 1986
36
Leukoregulin inhibits the growth of human glioblastoma in vitro. 62
3760159 1986
37
Analysis of a cytostatic lymphokine produced by incubation of lymphocytes with tumor cells: relationship to leukoregulin and distinction from recombinant lymphotoxin, recombinant tumor necrosis factor, and natural killer cytotoxic factor. 62
2423611 1986
38
Leukoregulin-increased plasma membrane permeability and associated ionic fluxes. 62
3084072 1986
39
Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon. 62
3881174 1985
40
The mechanism of leukoregulin enhancement of target cell susceptibility to NK cell mediated cytotoxicity in humans. 62
3862336 1985

Variations for Leukoregulin

Expression for Leukoregulin

Search GEO for disease gene expression data for Leukoregulin.

Pathways for Leukoregulin

GO Terms for Leukoregulin

Sources for Leukoregulin

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57 OMIM® (Updated 08-Dec-2022)
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62 PubMed
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72 UMLS via Orphanet
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