Aliases & Classifications for Leukoregulin

MalaCards integrated aliases for Leukoregulin:

Name: Leukoregulin 57

External Ids:

OMIM 57 602994

Summaries for Leukoregulin

MalaCards based summary : Leukoregulin is related to acute generalized exanthematous pustulosis and scabies. An important gene associated with Leukoregulin is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include t cells and skin, and related phenotypes are Reduced mammosphere formation and Synthetic lethal with MLN4924 (a NAE inhibitor)

Description from OMIM: 602994

Related Diseases for Leukoregulin

Diseases related to Leukoregulin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 acute generalized exanthematous pustulosis 10.4 CXCL8 PTGS2
2 scabies 10.4 CXCL8 IL1A
3 endometrial disease 10.4 CXCL8 PTGS2
4 sebaceous gland disease 10.4 CXCL8 IL1A
5 radiculopathy 10.4 CXCL8 IL1A
6 pharyngitis 10.4 CXCL8 PTGS2
7 aseptic meningitis 10.3 CXCL8 IL1A
8 pulpitis 10.3 CXCL8 IL1A
9 oral candidiasis 10.3 CXCL8 IL1A
10 bullous keratopathy 10.3 CXCL8 IL1A
11 bacterial vaginosis 10.3 CXCL8 IL1A
12 jaw cancer 10.3 CSF1 IL1A
13 stachybotrys chartarum 10.3 CSF1 IL1A
14 gastric ulcer 10.3 CXCL8 PTGS2
15 dyspepsia 10.3 CXCL8 PTGS2
16 clonorchiasis 10.3 CXCL8 TGFB1
17 peptic ulcer disease 10.3 CXCL8 PTGS2
18 stomach disease 10.2 CXCL8 PTGS2
19 tonsillitis 10.2 CXCL8 IL1A
20 tuberculous meningitis 10.2 CXCL8 TGFB1
21 aggressive periodontitis 10.2 CXCL8 IL1A
22 chorioamnionitis 10.2 CXCL8 IL1A
23 prostatitis 10.2 CXCL8 TGFB1
24 malignant histiocytosis 10.2 CSF1 IL1A
25 gingivitis 10.2 CXCL8 IL1A
26 esophagitis 10.1 CXCL8 PTGS2
27 ocular cicatricial pemphigoid 10.1 CSF1 TGFB1
28 epithelial basement membrane dystrophy 10.1 IL1A TGFB1
29 cervicitis 10.1
30 contact dermatitis 10.1 CXCL8 IL1A
31 toxic myocarditis 10.0 CXCL8 JUN
32 idiopathic neutropenia 10.0 IL1A TGFB1
33 osteomyelitis 10.0 CXCL8 IL1A
34 oral submucous fibrosis 10.0 PTGS2 TGFB1
35 cystitis 10.0 CXCL8 PTGS2
36 type i 9.9
37 urinary tract obstruction 9.9 PTGS2 TGFB1
38 gingival overgrowth 9.9 IL1A TGFB1
39 alveolar periostitis 9.9 JUN PTGS2
40 ureteral obstruction 9.8 PTGS2 TGFB1
41 autoinflammation, lipodystrophy, and dermatosis syndrome 9.8 CXCL8 IL1A PTGS2
42 bone inflammation disease 9.8 CXCL8 IL1A PTGS2
43 idiopathic interstitial pneumonia 9.8 CXCL8 TGFB1
44 silicosis 9.7 CXCL8 IL1A TGFB1
45 pneumoconiosis 9.7 CXCL8 IL1A TGFB1
46 interstitial lung disease 9.7 CXCL8 IL1A TGFB1
47 pulmonary fibrosis, idiopathic 9.7 CXCL8 IL1A TGFB1
48 monocytic leukemia 9.5 CSF1 CXCL8 JUN
49 helicobacter pylori infection 9.4 CXCL8 JUN
50 chronic fatigue syndrome 9.4 CXCL8 TGFB1

Graphical network of the top 20 diseases related to Leukoregulin:



Diseases related to Leukoregulin

Symptoms & Phenotypes for Leukoregulin

Clinical features from OMIM:

602994

GenomeRNAi Phenotypes related to Leukoregulin according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.35 CSF1 CXCL8 JUN PTGS2 TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.23 TGFB1 CXCL8 IL1A JUN
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.23 JUN TGFB1 CXCL8 IL1A

MGI Mouse Phenotypes related to Leukoregulin:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 CRAT CSF1 IL1A JUN PTGS2 TGFB1
2 integument MP:0010771 9.02 TGFB1 CSF1 IL1A JUN PTGS2

Drugs & Therapeutics for Leukoregulin

Search Clinical Trials , NIH Clinical Center for Leukoregulin

Genetic Tests for Leukoregulin

Anatomical Context for Leukoregulin

MalaCards organs/tissues related to Leukoregulin:

41
T Cells, Skin

Publications for Leukoregulin

Articles related to Leukoregulin:

(show all 20)
# Title Authors Year
1
Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts. ( 10600759 )
1999
2
Leukoregulin induction of protein expression in human orbital fibroblasts: evidence for anatomical site-restricted cytokine-target cell interactions. ( 9671777 )
1998
3
Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts. An in vitro model for connective tissue inflammation. ( 8798446 )
1996
4
Leukoregulin induces plasminogen activator inhibitor type 1 in human orbital fibroblasts. ( 7653518 )
1995
5
Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts. ( 7864077 )
1995
6
Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells. ( 1345813 )
1992
7
Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin. ( 1372007 )
1992
8
Leukoregulin, a T cell-derived cytokine, induces IL-8 gene expression and secretion in human skin fibroblasts. Demonstration and secretion in human skin fibroblasts. Demonstration of enhanced NF-kappa B binding and NF-kappa B-driven promoter activity. ( 1401924 )
1992
9
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin. ( 1356622 )
1992
10
Leukoregulin, a T-cell derived cytokine, upregulates stromelysin-1 gene expression in human dermal fibroblasts: evidence for the role of AP-1 in transcriptional activation. ( 1429874 )
1992
11
Transcriptional activation of fibroblast stromelysin-1 and collagenase gene expression by a novel lymphokine, leukoregulin. ( 1308987 )
1992
12
Leukoregulin down-regulates type I collagen mRNA levels and promoter activity in human dermal fibroblasts, and counteracts the up-regulation elicited by transforming growth factor-beta. ( 1622385 )
1992
13
The human lymphokine leukoregulin induces cell resistance to complement-mediated lysis. ( 1500082 )
1992
14
Modulation of human dermal fibroblast extracellular matrix metabolism by the lymphokine leukoregulin. ( 1646205 )
1991
15
1990 Sir Henry Wellcome medal and prize winner. Leukoregulin: a new biotherapeutic cytokine in the search for more effective anti-viral pharmacologic agents. ( 1851546 )
1991
16
Leukoregulin, a novel cytokine enhances the anti-herpesvirus actions of acyclovir. ( 1649027 )
1991
17
Implications of leukoregulin to autologous tumor-specific human T-cell populations. ( 2395004 )
1990
18
Influence of extracellular calcium on cell permeabilization and growth regulation by the lymphokine leukoregulin. ( 2112134 )
1990
19
Loss of leukoregulin up-regulation of natural killer but not lymphokine-activated killer lymphocytotoxicity in human papillomavirus 16 DNA-immortalized cervical epithelial cells. ( 2544741 )
1989
20
Preparative isoelectric focusing in ampholine electrofocusing columns versus immobiline polyacrylamide gel for the purification of biologically active leukoregulin. ( 2729555 )
1989

Variations for Leukoregulin

Expression for Leukoregulin

Search GEO for disease gene expression data for Leukoregulin.

Pathways for Leukoregulin

Pathways related to Leukoregulin according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 CSF1 CXCL8 IL1A JUN PTGS2 TGFB1
2
Show member pathways
13.59 CSF1 CXCL8 IL1A JUN PTGS2 TGFB1
3
Show member pathways
13.41 CSF1 CXCL8 IL1A JUN PTGS2 TGFB1
4
Show member pathways
13.12 CSF1 CXCL8 IL1A PTGS2 TGFB1
5
Show member pathways
13.07 CSF1 CXCL8 IL1A JUN TGFB1
6 12.63 CXCL8 JUN PTGS2 TGFB1
7 12.57 CSF1 IL1A JUN TGFB1
8
Show member pathways
12.38 CXCL8 JUN PTGS2 TGFB1
9
Show member pathways
12.27 IL1A JUN TGFB1
10
Show member pathways
12.25 IL1A JUN TGFB1
11
Show member pathways
12.16 CXCL8 JUN PTGS2
12
Show member pathways
12.1 CXCL8 IL1A JUN
13
Show member pathways
12.1 IL1A JUN PTGS2 TGFB1
14
Show member pathways
12.09 CXCL8 IL1A JUN PTGS2
15
Show member pathways
12.06 CXCL8 IL1A JUN PTGS2
16 12.02 CXCL8 IL1A JUN
17
Show member pathways
12.01 CXCL8 JUN TGFB1
18 12 CXCL8 IL1A TGFB1
19
Show member pathways
11.89 CXCL8 IL1A JUN TGFB1
20 11.87 CSF1 IL1A JUN TGFB1
21 11.81 CXCL8 IL1A PTGS2 TGFB1
22 11.79 CSF1 JUN PTGS2
23 11.76 CXCL8 IL1A PTGS2 TGFB1
24 11.69 CXCL8 IL1A JUN TGFB1
25 11.68 CXCL8 IL1A JUN
26 11.62 CXCL8 IL1A JUN TGFB1
27
Show member pathways
11.6 CXCL8 JUN PTGS2
28 11.59 CXCL8 IL1A JUN
29 11.53 JUN TGFB1
30 11.52 CXCL8 JUN
31 11.5 CXCL8 TGFB1
32 11.46 JUN TGFB1
33 11.44 CXCL8 JUN
34
Show member pathways
11.41 CSF1 JUN
35 11.38 CXCL8 TGFB1
36 11.37 JUN TGFB1
37 11.37 CSF1 TGFB1
38 11.36 CSF1 IL1A
39
Show member pathways
11.36 CXCL8 IL1A JUN PTGS2
40 11.33 IL1A JUN
41 11.32 JUN TGFB1
42 11.22 JUN PTGS2
43 11.2 CXCL8 JUN
44 11.18 CXCL8 TGFB1
45 11.16 CXCL8 JUN PTGS2 TGFB1
46 11.13 CSF1 IL1A TGFB1
47 11.1 JUN TGFB1
48 10.98 CSF1 CXCL8 IL1A JUN TGFB1
49 10.95 CSF1 CXCL8 IL1A PTGS2
50 10.92 CXCL8 PTGS2

GO Terms for Leukoregulin

Biological processes related to Leukoregulin according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.83 CSF1 IL1A TGFB1
2 cell proliferation GO:0008283 9.83 CSF1 IL1A TGFB1
3 positive regulation of apoptotic process GO:0043065 9.81 JUN PTGS2 TGFB1
4 positive regulation of cell proliferation GO:0008284 9.81 CSF1 JUN PTGS2 TGFB1
5 response to drug GO:0042493 9.79 JUN PTGS2 TGFB1
6 regulation of signaling receptor activity GO:0010469 9.78 CSF1 CXCL8 IL1A TGFB1
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 IL1A JUN TGFB1
8 angiogenesis GO:0001525 9.76 CXCL8 JUN PTGS2
9 response to lipopolysaccharide GO:0032496 9.73 CXCL8 JUN PTGS2
10 aging GO:0007568 9.71 JUN PTGS2 TGFB1
11 response to organic cyclic compound GO:0014070 9.67 JUN PTGS2 TGFB1
12 regulation of cell proliferation GO:0042127 9.67 CXCL8 JUN PTGS2 TGFB1
13 learning GO:0007612 9.66 JUN PTGS2
14 cellular response to heat GO:0034605 9.65 IL1A PTGS2
15 response to cytokine GO:0034097 9.65 JUN PTGS2
16 SMAD protein signal transduction GO:0060395 9.64 JUN TGFB1
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.64 JUN PTGS2
18 positive regulation of fibroblast proliferation GO:0048146 9.63 JUN TGFB1
19 positive regulation of cell division GO:0051781 9.62 IL1A TGFB1
20 negative regulation of cell cycle GO:0045786 9.61 PTGS2 TGFB1
21 positive regulation of protein secretion GO:0050714 9.61 IL1A TGFB1
22 response to organic substance GO:0010033 9.61 JUN PTGS2 TGFB1
23 osteoclast differentiation GO:0030316 9.6 CSF1 TGFB1
24 positive regulation of protein import into nucleus GO:0042307 9.58 PTGS2 TGFB1
25 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.57 JUN TGFB1
26 response to vitamin D GO:0033280 9.55 PTGS2 TGFB1
27 negative regulation of cell proliferation GO:0008285 9.55 CXCL8 IL1A JUN PTGS2 TGFB1
28 positive regulation of cellular protein metabolic process GO:0032270 9.52 CSF1 TGFB1
29 response to radiation GO:0009314 9.5 JUN PTGS2 TGFB1
30 positive regulation of monocyte differentiation GO:0045657 9.46 CSF1 JUN
31 positive regulation of vascular endothelial growth factor production GO:0010575 9.43 IL1A PTGS2 TGFB1
32 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.4 IL1A TGFB1
33 inflammatory response GO:0006954 9.35 CSF1 CXCL8 IL1A PTGS2 TGFB1
34 cytokine-mediated signaling pathway GO:0019221 9.02 CSF1 CXCL8 IL1A PTGS2 TGFB1

Molecular functions related to Leukoregulin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 JUN PTGS2 TGFB1
2 protein homodimerization activity GO:0042803 9.26 CSF1 JUN PTGS2 TGFB1
3 cytokine activity GO:0005125 8.92 CSF1 CXCL8 IL1A TGFB1

Sources for Leukoregulin

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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