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MCID: LKR001
MIFTS: 36

Leukorrhea

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Leukorrhea

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MalaCards integrated aliases for Leukorrhea:

Name: Leukorrhea 12 44 15
Discharge - Leukorrhea 12
Leukorrhea of Vagina 12

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:3766
ICD10 33 N89.8
MeSH 44 D007973
NCIt 50 C34775
SNOMED-CT 68 11057009 70856007
UMLS 73 C0023533
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Summaries for Leukorrhea

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Disease Ontology : 12 A vaginal discharge that is characterized by a whitish or yellow color.

MalaCards based summary : Leukorrhea, also known as discharge - leukorrhea, is related to bacterial vaginosis and vaginitis. An important gene associated with Leukorrhea is NFKBIA (NFKB Inhibitor Alpha), and among its related pathways/superpathways are Innate Immune System and Development VEGF signaling via VEGFR2 - generic cascades. The drugs Metronidazole and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include cervix, testes and uterus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Leukorrhea or (leucorrhoea British English) is a thick, whitish or yellowish vaginal discharge. There... more...

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Related Diseases for Leukorrhea

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Diseases related to Leukorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 bacterial vaginosis 10.3
2 vaginitis 10.0
3 vaginal discharge 10.0
4 salpingitis 10.0
5 endocervicitis 10.0
6 louse-borne relapsing fever 9.9 CRP NFKBIA
7 pyosalpinx 9.9 CRP PTGS2
8 bursitis 9.9 CRP PTGS2
9 pharyngitis 9.8 CRP PTGS2
10 peptic ulcer perforation 9.8 CRP PTGS2
11 colorectal adenoma 9.8 CRP PTGS2
12 cystitis 9.8 CRP PTGS2
13 bone inflammation disease 9.8 CRP PTGS2
14 proteasome-associated autoinflammatory syndrome 1 9.8 CRP PTGS2
15 intestinal disease 9.8 CRP PTGS2
16 rheumatic disease 9.8 CRP PTGS2
17 psoriatic arthritis 9.8 CRP NFKBIA
18 gastrointestinal system disease 9.8 CRP PTGS2
19 chronic kidney failure 9.6 CRP PTGS2

Graphical network of the top 20 diseases related to Leukorrhea:



Diseases related to Leukorrhea
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Symptoms & Phenotypes for Leukorrhea

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GenomeRNAi Phenotypes related to Leukorrhea according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.17 NFKBIA
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.17 NFKBIA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-13 9.17 PTGS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.17 PTGS2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.17 NFKBIA PTGS2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.17 PTGS2
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Drugs & Therapeutics for Leukorrhea

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Drugs for Leukorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 3,Not Applicable 443-48-1 4173
2
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
3 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
4 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
5 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
7 Clindamycin palmitate Phase 4
8 Clindamycin phosphate Phase 4
9
Secnidazole Approved Phase 3 3366-95-8
10
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
11
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
12
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
13
Tamoxifen Approved Phase 3 10540-29-1 2733526
14
Josamycin Investigational Phase 3 16846-24-5 5282165
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
16 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
17 Steroid Synthesis Inhibitors Phase 3
18 Antifungal Agents Phase 3
19 Hormones Phase 3
20 Hormone Antagonists Phase 3
21 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
22 Cytochrome P-450 Enzyme Inhibitors Phase 3
23 Antibiotics, Antitubercular Phase 3,Not Applicable
24 Antineoplastic Agents, Hormonal Phase 3
25 Aromatase Inhibitors Phase 3
26 Selective Estrogen Receptor Modulators Phase 3
27 Estrogen Receptor Modulators Phase 3
28 Estrogen Antagonists Phase 3
29 Estrogens Phase 3
30 Bone Density Conservation Agents Phase 3
31 Estrogen Receptor Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
2 Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge Completed NCT02111629 Phase 3 Fluconazole and Secnidazole
3 Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin) Completed NCT00718705 Phase 3 Josamycin;Placebo
4 Randomized Trial Of Exemestane Versus Continued Tamoxifen In Postmenopausal Women With Early Breast Cancer Completed NCT00038467 Phase 3 Tamoxifen;Exemestane
5 A Pilot Study to Evaluate the Safety and Activities of EW02 in Reducing Neutropenia Caused by Chemotherapy Unknown status NCT00555516 Phase 1, Phase 2
6 Recurrent Bacterial Vaginosis and Vaginal Acidifying Gel Trial Completed NCT00545181 Not Applicable Vaginal acidifying gel (RepHresh);Metronidazole control
7 Endometrial Local Injury Before First IVF : Evaluation of Pregnancy Rate Recruiting NCT02522806 Not Applicable
8 New Tool to Predict Risk of Spontaneous Preterm Birth in Asymptomatic High-risk Women Recruiting NCT03062020 Not Applicable
9 Cryotherapy for Human Papillomavirus Clearance in Biopsy-confirmed Cervical Low-grade Squamous Intraepithelial Lesions Terminated NCT00566579 Not Applicable
10 Study of Immunity at the Genital Mucosa of HIV-1 Infected and Healthy Women Terminated NCT01715103 Not Applicable

Search NIH Clinical Center for Leukorrhea

Cochrane evidence based reviews: leukorrhea

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Genetic Tests for Leukorrhea

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Anatomical Context for Leukorrhea

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MalaCards organs/tissues related to Leukorrhea:

41
Cervix, Testes, Uterus, Kidney, Bone, Breast
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Publications for Leukorrhea

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Articles related to Leukorrhea:

(show all 39)
# Title Authors Year
1
Computerized detection of leukocytes in microscopic leukorrhea images. ( 28555888 )
2017
2
Perceptions and Knowledge about Leukorrhea in a Slum Dwelling South Asian Community. ( 24971133 )
2014
3
Correlation of leukorrhea and Trichomonas vaginalis infection. ( 23678058 )
2013
4
Cervical leukorrhea is correlated with bacterial vaginosis. ( 21315345 )
2011
5
By the way, doctor. I'm a healthy 62-year-old. In the past three months, I've developed a vaginal discharge and discomfort. tests for vaginal infections have been negative. I've tried douching and sitz baths. I started using vaginal estrogen (Premarin) cream about two months ago. Nothing helps. I'd appreciate your thoughts on this problem, which my gynecologist calls "chronic leukorrhea.". ( 20217961 )
2010
6
Patient 60 years old with post menopausal metrorrhagia and fetid leukorrhea. ( 19617161 )
2008
7
Leukorrhea and bacterial vaginosis as in-office predictors of cervical infection in high-risk women. ( 12383553 )
2002
8
Combination of bacterial vaginosis and leukorrhea as a predictor of cervical chlamydial or gonococcal infection. ( 12039120 )
2002
9
Cultural and biomedical meanings of the complaint of leukorrhea in South Asian women. ( 11348516 )
2001
10
Bacteriological study of leukorrhea. ( 6813525 )
1982
11
Corynebacterium vaginale (Haemophilus vaginalis) in women with leukorrhea. ( 984128 )
1976
12
LEUKORRHEA IN THE ADULT FEMALE. ( 14211262 )
1965
13
Hemophilus vaginalis in leukorrhea: incidence, diagnosis, and treatment. ( 13993388 )
1963
14
New relief for leukorrhea. ( 14464077 )
1962
15
Uterus didelphys presenting as leukorrhea. Report of a case. ( 13695052 )
1961
16
Leukorrhea and vaginitis. ( 14494891 )
1961
17
Leukorrhea; its causes and a new vaginal classification. ( 13668938 )
1959
18
LEUKORRHEA during childhood. ( 13627071 )
1959
19
Endamoeba histolytica in leukorrhea and salpingitis. ( 13444376 )
1957
20
Leukorrhea. ( 13394855 )
1957
21
[Gynecological experiences with albothyl; contribution to the colposcopic & cytological control of leukorrhea & erosion of the cervix]. ( 13493441 )
1957
22
Leukorrhea; causes and management. ( 13286644 )
1956
23
Leukorrhea; therapy in the office management. ( 13333451 )
1956
24
Leukorrhea therapy of 510 cases. ( 14370496 )
1955
25
The cytolytic changes of the vaginal epithelial cells and the leukorrhea following estrogenic therapy. ( 14388062 )
1955
26
Treatment of leukorrhea with douches and broad spectrum therapy. ( 13268014 )
1955
27
Psychosomatic leukorrhea; report of a case. ( 13230917 )
1955
28
Acid detergent douche therapy of leukorrhea. ( 13150198 )
1954
29
The office management of leukorrhea. ( 13016857 )
1953
30
Leukorrhea. ( 13085113 )
1953
31
Chlorophyll, studies on the clinical application and its action in the treatment of leukorrhea vaginalis. ( 13004278 )
1952
32
Leukorrhea in general practice; its diagnosis and treatment. ( 12992109 )
1952
33
Chlorophyll; studies on the clinical application and its action in the treatment of leukorrhea vaginalis. ( 13010909 )
1952
34
Leukorrhea of pregnancy; subsequent study of caprokol jelly. ( 15410418 )
1950
35
Leukorrhea, diagnosis and treatment. ( 18152375 )
1949
36
The rational management of leukorrhea. ( 18894219 )
1948
37
Leukorrhea; its causes and treatment. ( 20254969 )
1947
38
Leukorrhea. ( 20255882 )
1947
39
ELECTROTHERMOCAUTERY TREATMENT OF LEUKORRHEA DUE TO ENDOCERVICITIS. ( 18739169 )
1923
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Variations for Leukorrhea

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Expression for Leukorrhea

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Search GEO for disease gene expression data for Leukorrhea.
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Pathways for Leukorrhea

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Pathways related to Leukorrhea according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.41 CRP DYNC1I2 NFKBIA PTGS2
2
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 11.88 NFKBIA PTGS2
3
Toll Comparative Pathway 64
Show member pathways
 11.82 NFKBIA PTGS2
4
Selenium Micronutrient Network 1
Show member pathways
 11.81 CRP PTGS2
5
IL-17 Family Signaling Pathways 65
Show member pathways
 11.79 NFKBIA PTGS2
6
Toxoplasmosis 37
Show member pathways
 11.7 NFKBIA PTGS2
7
IL-1 Family Signaling Pathways 65
Show member pathways
 11.65 NFKBIA PTGS2
8
C-type lectin receptor signaling pathway 37
Show member pathways
 11.61 NFKBIA PTGS2
9
TNF signaling pathway 37
11.36 NFKBIA PTGS2
10
NF-kappa B signaling pathway 37
11.23 NFKBIA PTGS2
11
Small cell lung cancer 37
11.12 NFKBIA PTGS2
12
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.76 NFKBIA PTGS2
13
Overview of nanoparticle effects 1
9.9 CRP PTGS2
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GO Terms for Leukorrhea

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Biological processes related to Leukorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.32 NFKBIA PTGS2
2 response to lipopolysaccharide GO:0032496 9.26 NFKBIA PTGS2
3 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.16 CRP NFKBIA
4 negative regulation of blood vessel diameter GO:0097756 8.96 CRP PTGS2
5 negative regulation of lipid storage GO:0010888 8.62 CRP NFKBIA
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Sources for Leukorrhea

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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