Aliases & Classifications for Leukostasis

MalaCards integrated aliases for Leukostasis:

Name: Leukostasis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12986
MeSH 44 D018921
NCIt 50 C4062
SNOMED-CT 68 30419000
UMLS 73 C0282548

Summaries for Leukostasis

MalaCards based summary : Leukostasis is related to ischemia and microvascular complications of diabetes 5. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are fMLP Pathway and Allograft rejection. Affiliated tissues include myeloid, endothelial and monocytes, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in... more...

Related Diseases for Leukostasis

Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.3 ICAM1 MPO VEGFA
2 microvascular complications of diabetes 5 29.6 ICAM1 KDR VCAM1 VEGFA
3 cortical thymoma 10.7 ICAM1 VCAM1
4 rapidly progressive glomerulonephritis 10.6 ICAM1 MPO
5 limbal stem cell deficiency 10.6 ICAM1 VCAM1
6 acute proliferative glomerulonephritis 10.6 ICAM1 MPO
7 arteriosclerosis obliterans 10.6 ICAM1 VCAM1
8 macular retinal edema 10.5 ICAM1 VEGFA
9 pulmonary aspergilloma 10.5 MPO VEGFA
10 heterophyiasis 10.5 ICAM1 SELE
11 hymenolepiasis 10.5 ICAM1 SELE
12 dengue disease 10.4 ICAM1 VCAM1
13 leukemia 10.4
14 diabetic macular edema 10.4 ICAM1 VEGFA
15 hydrops, lactic acidosis, and sideroblastic anemia 10.4 MPO VEGFA
16 angiokeratoma circumscriptum 10.4 KDR VEGFA
17 critical limb ischemia 10.4 SELE VEGFA
18 oral lichen planus 10.4 ICAM1 VCAM1
19 capillary hemangioma 10.3 KDR VEGFA
20 skin hemangioma 10.3 KDR VEGFA
21 radiation proctitis 10.3 KDR VEGFA
22 epithelioid hemangioendothelioma 10.3 KDR VEGFA
23 retinitis 10.3
24 primary progressive multiple sclerosis 10.3 ICAM1 VCAM1
25 kuhnt-junius degeneration 10.3 KDR VEGFA
26 plasmodium vivax malaria 10.3 ICAM1 SELE
27 hydrocele 10.3 SELE VEGFA
28 acute hemorrhagic leukoencephalitis 10.3 KDR VEGFA
29 immune-complex glomerulonephritis 10.3 ICAM1 MPO VCAM1
30 angiomatous meningioma 10.3 KDR VEGFA
31 henoch-schoenlein purpura 10.3 ICAM1 MPO VCAM1
32 crescentic glomerulonephritis 10.3 ICAM1 MPO VCAM1
33 polyarteritis nodosa 10.3 MPO SELE
34 lymphangioma 10.3 KDR VEGFA
35 glomerulonephritis 10.2 ICAM1 MPO VCAM1
36 allergic rhinitis 10.2 ICAM1 MPO VCAM1
37 proctitis 10.2 KDR MPO
38 microvascular complications of diabetes 1 10.2 ICAM1 VCAM1 VEGFA
39 coats disease 10.2 KDR VEGFA
40 cutaneous lupus erythematosus 10.2 ICAM1 SELE
41 myeloid leukemia 10.2
42 peripheral artery disease 10.2 VCAM1 VEGFA
43 vascular cancer 10.2 KDR VEGFA
44 toxicodendron dermatitis 10.1 ICAM1 SELL
45 lymphocytic vasculitis 10.1 ICAM1 SELE VCAM1
46 mooren's ulcer 10.1 ICAM1 SELE VCAM1
47 subendocardial myocardial infarction 10.1 ICAM1 SELE VCAM1
48 actinic prurigo 10.1 ICAM1 SELE VCAM1
49 rheumatoid vasculitis 10.1 ICAM1 SELE VCAM1
50 cytomegalovirus infection 10.1 ICAM1 SELE VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to Leukostasis

Symptoms & Phenotypes for Leukostasis

MGI Mouse Phenotypes related to Leukostasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 VEGFA NFATC4 ICAM1 SELE KDR SELL
2 cellular MP:0005384 10.01 NFATC2 VEGFA NFATC4 ICAM1 SELE KDR
3 growth/size/body region MP:0005378 9.97 NFATC2 VEGFA NFATC4 ICAM1 SELE KDR
4 hematopoietic system MP:0005397 9.97 VEGFA NFATC4 ICAM1 SELE KDR SELL
5 immune system MP:0005387 9.86 VEGFA ICAM1 SELE KDR SELL MPO
6 muscle MP:0005369 9.63 NFATC2 VEGFA NFATC4 ICAM1 KDR MPO
7 respiratory system MP:0005388 9.35 NFATC2 VEGFA SELE KDR SELL
8 vision/eye MP:0005391 9.02 VEGFA NFATC2 ICAM1 SELE KDR

Drugs & Therapeutics for Leukostasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study GX-G3 in Healthy Subjects Completed NCT01951027 Phase 1 GX-G3 12.5 μg/kg or Placebo;GX-G3 25 μg/kg or Placebo;GX-G3 50 μg/kg or Placebo;GX-G3 100 μg/kg or Placebo

Search NIH Clinical Center for Leukostasis

Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

MalaCards organs/tissues related to Leukostasis:

41
Myeloid, Endothelial, Monocytes, Neutrophil, Lung, Spleen, Brain

Publications for Leukostasis

Articles related to Leukostasis:

(show top 50) (show all 121)
# Title Authors Year
1
Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-I_ B signaling. ( 28274631 )
2017
2
Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy? ( 28724696 )
2017
3
Leukostasis: Management to Prevent Crisis in Acute Leukemiaa8c. ( 29149122 )
2017
4
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. ( 28351645 )
2017
5
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. ( 28060107 )
2017
6
Comparing leukapheresis protocols for an AML patient with symptomatic leukostasis. ( 28940295 )
2017
7
Hyperleukocytosis and leukostasis: management of a medical emergency. ( 27967252 )
2016
8
High Output Cardiac Failure in a Patient Presenting with Acute Myeloid Leukemia and Leukostasis. ( 29193920 )
2016
9
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. ( 27931222 )
2016
10
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. ( 26670831 )
2016
11
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. ( 27018197 )
2016
12
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. ( 26157660 )
2015
13
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. ( 26247460 )
2015
14
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. ( 26527057 )
2015
15
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. ( 26267387 )
2015
16
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. ( 26485422 )
2015
17
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. ( 25031169 )
2014
18
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). ( 25593509 )
2014
19
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. ( 24724788 )
2014
20
Genetic mutations in patients with acute myeloid leukemia and leukostasis. ( 23548579 )
2013
21
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. ( 24551717 )
2013
22
Hyperleukocytosis, leukostasis and leukapheresis: practice management. ( 22364832 )
2012
23
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. ( 22677420 )
2012
24
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. ( 22427570 )
2012
25
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. ( 21574176 )
2011
26
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. ( 22224069 )
2011
27
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. ( 21825265 )
2011
28
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. ( 21945644 )
2011
29
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. ( 21212173 )
2011
30
Pulmonary leukostasis mimicking tuberculosis in endemic area. ( 20004472 )
2010
31
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. ( 19391131 )
2009
32
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. ( 19250642 )
2009
33
Targeting leukostasis for the treatment of early diabetic retinopathy. ( 19619127 )
2009
34
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. ( 17962481 )
2007
35
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. ( 17251488 )
2007
36
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. ( 17653050 )
2007
37
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. ( 17942876 )
2007
38
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. ( 17381536 )
2007
39
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. ( 17107717 )
2007
40
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. ( 17652361 )
2007
41
Role of angiotensin II in retinal leukostasis in the diabetic rat. ( 16822509 )
2006
42
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. ( 16909741 )
2006
43
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. ( 16519701 )
2006
44
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. ( 16797605 )
2006
45
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. ( 15876254 )
2005
46
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. ( 15790913 )
2005
47
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. ( 15377482 )
2004
48
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. ( 15197401 )
2004
49
The role of advanced glycation end products in retinal microvascular leukostasis. ( 14507893 )
2003
50
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. ( 12606527 )
2003

Variations for Leukostasis

Expression for Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for Leukostasis

Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.8 KDR NFATC2 NFATC4 VEGFA
2
Show member pathways
12.67 ICAM1 NFATC2 NFATC4 VEGFA
3
Show member pathways
12.44 ICAM1 KDR VCAM1 VEGFA
4
Show member pathways
12.38 KDR NFATC2 NFATC4 VEGFA
5
Show member pathways
12.36 ICAM1 NFATC2 NFATC4 VEGFA
6 12.34 MPO NFATC2 NFATC4 VCAM1
7
Show member pathways
12.21 ICAM1 NFATC2 NFATC4 VCAM1
8 12.2 ICAM1 NFATC2 NFATC4 VCAM1
9
Show member pathways
11.96 ICAM1 KDR VCAM1
10
Show member pathways
11.94 ICAM1 KDR SELE VCAM1 VEGFA
11 11.9 ICAM1 SELL VCAM1
12 11.88 KDR VCAM1 VEGFA
13 11.83 ICAM1 SELE SELL VCAM1
14 11.81 ICAM1 VCAM1 VEGFA
15 11.78 ICAM1 SELE VCAM1
16 11.62 ICAM1 SELE VCAM1 VEGFA
17 11.35 ICAM1 MPO
18 11.34 ICAM1 SELE VCAM1
19 11.33 KDR VEGFA
20 11.31 ICAM1 VCAM1
21
Show member pathways
11.31 NFATC2 NFATC4
22 11.3 NFATC2 NFATC4
23 11.3 NFATC2 NFATC4 VEGFA
24
Show member pathways
11.28 KDR VEGFA
25 11.27 KDR VEGFA
26 11.26 ICAM1 SELE VCAM1
27 11.23 SELE SELL
28 11.21 NFATC2 NFATC4
29 11.16 KDR VEGFA
30 11.16 ICAM1 KDR SELE VCAM1 VEGFA
31 11.12 ICAM1 SELE VCAM1
32
Show member pathways
11.06 ICAM1 SELE VCAM1 VEGFA
33 11 KDR VEGFA
34 10.84 VCAM1 VEGFA
35
Show member pathways
10.8 KDR VEGFA
36 10.64 ICAM1 MPO VCAM1

GO Terms for Leukostasis

Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.43 ICAM1 SELL VCAM1
2 membrane raft GO:0045121 9.33 ICAM1 KDR SELE
3 cell surface GO:0009986 9.26 ICAM1 SELL VCAM1 VEGFA
4 nuclear transcription factor complex GO:0044798 8.62 NFATC2 NFATC4

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.87 ICAM1 SELE SELL VCAM1
2 regulation of immune response GO:0050776 9.77 ICAM1 SELL VCAM1
3 leukocyte migration GO:0050900 9.76 ICAM1 SELE SELL
4 extracellular matrix organization GO:0030198 9.73 ICAM1 KDR VCAM1
5 response to hypoxia GO:0001666 9.7 ICAM1 VCAM1 VEGFA
6 regulation of cell shape GO:0008360 9.67 ICAM1 KDR VEGFA
7 positive regulation of endothelial cell migration GO:0010595 9.63 KDR VEGFA
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.62 KDR VEGFA
9 ovarian follicle development GO:0001541 9.62 ICAM1 VEGFA
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 ICAM1 KDR
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.61 KDR VEGFA
12 branching involved in blood vessel morphogenesis GO:0001569 9.59 NFATC4 VEGFA
13 cytokine production GO:0001816 9.58 NFATC2 NFATC4
14 response to lipopolysaccharide GO:0032496 9.56 ICAM1 MPO SELE VCAM1
15 positive regulation of focal adhesion assembly GO:0051894 9.55 KDR VEGFA
16 positive regulation of receptor internalization GO:0002092 9.54 SELE VEGFA
17 calcium-mediated signaling using intracellular calcium source GO:0035584 9.51 KDR VCAM1
18 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.5 ICAM1 SELE VCAM1
19 cell migration involved in sprouting angiogenesis GO:0002042 9.48 KDR VEGFA
20 positive regulation of positive chemotaxis GO:0050927 9.46 KDR VEGFA
21 calcineurin-NFAT signaling cascade GO:0033173 9.43 NFATC2 NFATC4
22 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.4 KDR VEGFA
23 membrane to membrane docking GO:0022614 9.37 ICAM1 VCAM1
24 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.33 KDR VCAM1 VEGFA
25 leukocyte cell-cell adhesion GO:0007159 9.13 ICAM1 SELE VCAM1
26 leukocyte tethering or rolling GO:0050901 8.8 SELE SELL VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.33 MPO SELL VEGFA
2 integrin binding GO:0005178 9.13 ICAM1 KDR VCAM1
3 oligosaccharide binding GO:0070492 8.62 SELE SELL

Sources for Leukostasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....