MCID: LKS001
MIFTS: 43

Leukostasis

Categories: Blood diseases

Aliases & Classifications for Leukostasis

MalaCards integrated aliases for Leukostasis:

Name: Leukostasis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12986
MeSH 44 D018921
NCIt 50 C4062
SNOMED-CT 68 30419000
UMLS 73 C0282548

Summaries for Leukostasis

MalaCards based summary : Leukostasis is related to ischemia and granulocytopenia. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Human cytomegalovirus infection and fMLP Pathway. Affiliated tissues include myeloid, bone and endothelial, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in... more...

Related Diseases for Leukostasis

Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.4 ICAM1 MPO VEGFA
2 granulocytopenia 30.4 MPO SELL
3 microvascular complications of diabetes 5 30.2 ICAM1 KDR VCAM1 VEGFA
4 leukemia 10.6
5 myeloid leukemia 10.4
6 leukemia, acute myeloid 10.3
7 cortical thymoma 10.2 ICAM1 VCAM1
8 shwartzman phenomenon 10.2 ICAM1 VCAM1
9 brachydactyly, type e2 10.2 ICAM1 VCAM1
10 limbal stem cell deficiency 10.2 ICAM1 VCAM1
11 acute proliferative glomerulonephritis 10.2 ICAM1 MPO
12 rapidly progressive glomerulonephritis 10.2 ICAM1 MPO
13 lymphoma 10.2
14 pollen allergy 10.2 ICAM1 MPO
15 macular retinal edema 10.2 ICAM1 VEGFA
16 arteriosclerosis obliterans 10.2 ICAM1 VCAM1
17 goodpasture syndrome 10.2 MPO VCAM1
18 heterophyiasis 10.2 ICAM1 SELE
19 pulmonary aspergilloma 10.2 MPO VEGFA
20 hymenolepiasis 10.1 ICAM1 SELE
21 dengue disease 10.1 ICAM1 VCAM1
22 hydrops, lactic acidosis, and sideroblastic anemia 10.1 MPO VEGFA
23 leukemia, chronic myeloid 10.1
24 respiratory failure 10.1
25 diabetic macular edema 10.1 ICAM1 VEGFA
26 angiokeratoma circumscriptum 10.1 KDR VEGFA
27 proctitis 10.1 KDR MPO
28 critical limb ischemia 10.1 SELE VEGFA
29 limb ischemia 10.1 KDR VEGFA
30 oral lichen planus 10.1 ICAM1 VCAM1
31 skin hemangioma 10.1 KDR VEGFA
32 radiation proctitis 10.1 KDR VEGFA
33 grange syndrome 10.1 SELE VCAM1
34 epithelioid hemangioendothelioma 10.1 KDR VEGFA
35 capillary hemangioma 10.1 KDR VEGFA
36 plasmodium vivax malaria 10.1 ICAM1 SELE
37 immune-complex glomerulonephritis 10.1 ICAM1 MPO VCAM1
38 glomerulonephritis 10.1 ICAM1 MPO VCAM1
39 vertebrobasilar insufficiency 10.1 ICAM1 SELE
40 henoch-schoenlein purpura 10.1 ICAM1 MPO VCAM1
41 drug-induced lupus erythematosus 10.1 KDR VEGFA
42 crescentic glomerulonephritis 10.1 ICAM1 MPO VCAM1
43 angiomatous meningioma 10.1 KDR VEGFA
44 localized scleroderma 10.1 SELE VCAM1
45 lymphangioma 10.1 KDR VEGFA
46 allergic rhinitis 10.1 ICAM1 MPO VCAM1
47 cutaneous lupus erythematosus 10.1 ICAM1 SELE
48 coats disease 10.1 KDR VEGFA
49 microvascular complications of diabetes 1 10.1 ICAM1 VCAM1 VEGFA
50 maturity-onset diabetes of the young, type 7 10.1 SELE VCAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to Leukostasis

Symptoms & Phenotypes for Leukostasis

MGI Mouse Phenotypes related to Leukostasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ICAM1 KDR MPO NFATC4 SELE SELL
2 cellular MP:0005384 10.01 ICAM1 KDR NFATC2 NFATC4 SELE SELL
3 growth/size/body region MP:0005378 9.97 ICAM1 KDR NFATC2 NFATC4 SELE SELL
4 hematopoietic system MP:0005397 9.97 ICAM1 KDR MPO NFATC2 NFATC4 SELE
5 immune system MP:0005387 9.86 ICAM1 KDR MPO NFATC2 SELE SELL
6 muscle MP:0005369 9.63 ICAM1 KDR MPO NFATC2 NFATC4 VEGFA
7 respiratory system MP:0005388 9.35 KDR NFATC2 SELE SELL VEGFA
8 vision/eye MP:0005391 9.02 ICAM1 KDR NFATC2 SELE VEGFA

Drugs & Therapeutics for Leukostasis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study GX-G3 in Healthy Subjects Completed NCT01951027 Phase 1 GX-G3 12.5 μg/kg or Placebo;GX-G3 25 μg/kg or Placebo;GX-G3 50 μg/kg or Placebo;GX-G3 100 μg/kg or Placebo

Search NIH Clinical Center for Leukostasis

Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

MalaCards organs/tissues related to Leukostasis:

41
Myeloid, Bone, Endothelial, Monocytes, Brain, Skin, Bone Marrow

Publications for Leukostasis

Articles related to Leukostasis:

(show top 50) (show all 123)
# Title Authors Year
1
Leukostasis retinopathy: An uncommon visual threatening complication of chronic myeloid leukemia with severe hyperleukocytosis - A case report and review of the literature. ( 30451209 )
2018
2
Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-I_ B signaling. ( 28274631 )
2017
3
Is leukostasis a crucial step or epiphenomenon in the pathogenesis of diabetic retinopathy? ( 28724696 )
2017
4
Leukostasis: Management to Prevent Crisis in Acute Leukemiaa8c. ( 29149122 )
2017
5
Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis. ( 28351645 )
2017
6
Pulmonary Leukostasis: Treatment When Cytoreduction Does Not Suffice. ( 28060107 )
2017
7
Comparing leukapheresis protocols for an AML patient with symptomatic leukostasis. ( 28940295 )
2017
8
Hyperleukocytosis and leukostasis: management of a medical emergency. ( 27967252 )
2016
9
High Output Cardiac Failure in a Patient Presenting with Acute Myeloid Leukemia and Leukostasis. ( 29193920 )
2016
10
miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling. ( 27931222 )
2016
11
Exchange Transfusion and Leukapheresis in Pediatric Patients with AML With High Risk of Early Death by Bleeding and Leukostasis. ( 26670831 )
2016
12
Leukostasis in adult acute hyperleukocytic leukemia: a clinician's digest. ( 27018197 )
2016
13
Pulmonary leukostasis with severe respiratory impairment as a debut of acute myeloid leukemia. ( 26157660 )
2015
14
Leukostasis Retinopathy: A New Clinical Manifestation of Chronic Myeloid Leukemia With Severe Hyperleukocytosis. ( 26247460 )
2015
15
NFAT isoforms play distinct roles in TNFI+-induced retinal leukostasis. ( 26527057 )
2015
16
How we approach a patient with symptoms of leukostasis requiring emergent leukocytapheresis. ( 26267387 )
2015
17
Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. ( 26485422 )
2015
18
Pathologic rupture of the spleen in a patient with acute myelogenous leukemia and leukostasis. ( 25031169 )
2014
19
The effect of puerarin against IL-1I^-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). ( 25593509 )
2014
20
Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. ( 24724788 )
2014
21
Genetic mutations in patients with acute myeloid leukemia and leukostasis. ( 23548579 )
2013
22
Leukostasis in an Adult with AML Presenting as Multiple High Attenuation Brain Masses on CT. ( 24551717 )
2013
23
Hyperleukocytosis, leukostasis and leukapheresis: practice management. ( 22364832 )
2012
24
CD11b+ bone marrow-derived monocytes are the major leukocyte subset responsible for retinal capillary leukostasis in experimental diabetes in mouse and express high levels of CCR5 in the circulation. ( 22677420 )
2012
25
Intra-ophthalmic artery chemotherapy triggers vascular toxicity through endothelial cell inflammation and leukostasis. ( 22427570 )
2012
26
Therapeutic leukapheresis in patients with leukostasis secondary to acute myelogenous leukemia. ( 21574176 )
2011
27
Rapid treatment of leukostasis in leukemic mantle cell lymphoma using therapeutic leukapheresis: a case report. ( 22224069 )
2011
28
Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. ( 21825265 )
2011
29
Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. ( 21945644 )
2011
30
TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. ( 21212173 )
2011
31
Pulmonary leukostasis mimicking tuberculosis in endemic area. ( 20004472 )
2010
32
Reliability of leukostasis grading score to identify patients with high-risk hyperleukocytosis. ( 19391131 )
2009
33
Phosphomannopentaose sulfate (PI-88) inhibits retinal leukostasis in diabetic rat. ( 19250642 )
2009
34
Targeting leukostasis for the treatment of early diabetic retinopathy. ( 19619127 )
2009
35
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. ( 17962481 )
2007
36
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. ( 17251488 )
2007
37
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. ( 17653050 )
2007
38
Images in clinical medicine. FLT3 Mutation and acute myelogenous leukemia with leukostasis. ( 17942876 )
2007
39
A case report of therapeutic leukapheresis in an adult with chronic myelogenous leukemia presenting with hyperleukocytosis and leukostasis. ( 17381536 )
2007
40
TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. ( 17107717 )
2007
41
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis. ( 17652361 )
2007
42
Role of angiotensin II in retinal leukostasis in the diabetic rat. ( 16822509 )
2006
43
Hyperleukocytosis associated pulmonary leukostasis in acute leukaemia. ( 16909741 )
2006
44
Correlation between expression of CD56/NCAM and severe leukostasis in hyperleukocytic acute myelomonocytic leukaemia. ( 16519701 )
2006
45
Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. ( 16797605 )
2006
46
Grading of symptoms in hyperleukocytic leukaemia: a clinical model for the role of different blast types and promyelocytes in the development of leukostasis syndrome. ( 15876254 )
2005
47
Intravitreal injection of corticosteroid attenuates leukostasis and vascular leakage in experimental diabetic retina. ( 15790913 )
2005
48
Management of life-threatening pulmonary leukostasis with single agent imatinib mesylate during CML myeloid blast crisis. ( 15377482 )
2004
49
Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome. ( 15197401 )
2004
50
The role of advanced glycation end products in retinal microvascular leukostasis. ( 14507893 )
2003

Variations for Leukostasis

Expression for Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for Leukostasis

Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 ICAM1 NFATC2 NFATC4 VEGFA
2
Show member pathways
12.79 KDR NFATC2 NFATC4 VEGFA
3
Show member pathways
12.75 KDR NFATC2 SELE VEGFA
4
Show member pathways
12.66 ICAM1 NFATC2 NFATC4 VEGFA
5
Show member pathways
12.43 ICAM1 KDR VCAM1 VEGFA
6
Show member pathways
12.37 KDR NFATC2 NFATC4 VEGFA
7 12.34 MPO NFATC2 NFATC4 VCAM1
8
Show member pathways
12.21 ICAM1 NFATC2 NFATC4 VCAM1
9 12.2 ICAM1 NFATC2 NFATC4 VCAM1
10
Show member pathways
12.06 NFATC2 NFATC4 VEGFA
11
Show member pathways
12.02 ICAM1 NFATC2 NFATC4 VCAM1
12
Show member pathways
11.96 ICAM1 KDR VCAM1
13
Show member pathways
11.94 ICAM1 KDR SELE VCAM1 VEGFA
14 11.89 ICAM1 SELL VCAM1
15 11.88 KDR VCAM1 VEGFA
16 11.83 ICAM1 SELE SELL VCAM1
17 11.8 ICAM1 VCAM1 VEGFA
18 11.78 ICAM1 SELE VCAM1
19 11.62 ICAM1 SELE VCAM1 VEGFA
20 11.36 ICAM1 MPO
21 11.34 KDR VEGFA
22 11.34 ICAM1 SELE VCAM1
23 11.31 ICAM1 VCAM1
24 11.31 NFATC2 NFATC4
25 11.3 NFATC2 NFATC4 VEGFA
26
Show member pathways
11.28 KDR VEGFA
27 11.28 KDR VEGFA
28 11.26 ICAM1 SELE VCAM1
29 11.24 SELE SELL
30 11.21 NFATC2 NFATC4
31 11.16 KDR VEGFA
32 11.16 ICAM1 KDR SELE VCAM1 VEGFA
33 11.12 ICAM1 SELE VCAM1
34
Show member pathways
11.06 ICAM1 SELE VCAM1 VEGFA
35 11 KDR VEGFA
36 10.83 VCAM1 VEGFA
37
Show member pathways
10.8 KDR VEGFA
38 10.64 ICAM1 MPO VCAM1

GO Terms for Leukostasis

Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 ICAM1 KDR SELE SELL VCAM1
2 membrane raft GO:0045121 9.43 ICAM1 KDR SELE
3 cell surface GO:0009986 9.26 ICAM1 SELL VCAM1 VEGFA
4 nuclear transcription factor complex GO:0044798 8.62 NFATC2 NFATC4

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 ICAM1 SELE SELL VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.8 ICAM1 VCAM1 VEGFA
3 regulation of immune response GO:0050776 9.78 ICAM1 SELL VCAM1
4 extracellular matrix organization GO:0030198 9.77 ICAM1 KDR VCAM1
5 leukocyte migration GO:0050900 9.74 ICAM1 SELE SELL
6 response to hypoxia GO:0001666 9.7 ICAM1 VCAM1 VEGFA
7 regulation of cell shape GO:0008360 9.67 ICAM1 KDR VEGFA
8 positive regulation of blood vessel endothelial cell migration GO:0043536 9.64 KDR VEGFA
9 response to ionizing radiation GO:0010212 9.63 ICAM1 VCAM1
10 ovarian follicle development GO:0001541 9.62 ICAM1 VEGFA
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.62 KDR VEGFA
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 ICAM1 KDR
13 cytokine production GO:0001816 9.6 NFATC2 NFATC4
14 branching involved in blood vessel morphogenesis GO:0001569 9.58 NFATC4 VEGFA
15 positive regulation of focal adhesion assembly GO:0051894 9.56 KDR VEGFA
16 response to lipopolysaccharide GO:0032496 9.56 ICAM1 MPO SELE VCAM1
17 positive regulation of receptor internalization GO:0002092 9.55 SELE VEGFA
18 calcium-mediated signaling using intracellular calcium source GO:0035584 9.54 KDR VCAM1
19 cell migration involved in sprouting angiogenesis GO:0002042 9.51 KDR VEGFA
20 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.5 ICAM1 SELE VCAM1
21 vascular endothelial growth factor signaling pathway GO:0038084 9.48 KDR VEGFA
22 calcineurin-NFAT signaling cascade GO:0033173 9.46 NFATC2 NFATC4
23 positive regulation of positive chemotaxis GO:0050927 9.43 KDR VEGFA
24 membrane to membrane docking GO:0022614 9.4 ICAM1 VCAM1
25 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.37 KDR VEGFA
26 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.33 KDR VCAM1 VEGFA
27 leukocyte cell-cell adhesion GO:0007159 9.13 ICAM1 SELE VCAM1
28 leukocyte tethering or rolling GO:0050901 8.8 SELE SELL VCAM1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 ICAM1 KDR SELE
2 heparin binding GO:0008201 9.33 MPO SELL VEGFA
3 integrin binding GO:0005178 9.13 ICAM1 KDR VCAM1
4 oligosaccharide binding GO:0070492 8.62 SELE SELL

Sources for Leukostasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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