MCID: LKS001
MIFTS: 40

Leukostasis

Categories: Blood diseases
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Aliases & Classifications for Leukostasis

MalaCards integrated aliases for Leukostasis:

Name: Leukostasis 11 53 43 14 16 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:12986
MeSH 43 D018921
NCIt 49 C4062
SNOMED-CT 68 30419000
UMLS 71 C0282548

Summaries for Leukostasis

MalaCards based summary: Leukostasis is related to microvascular complications of diabetes 5 and disseminated intravascular coagulation. An important gene associated with Leukostasis is ICAM1 (Intercellular Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. Affiliated tissues include myeloid, bone marrow and endothelial, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Leukostasis (also called symptomatic hyperleukocytosis) is a medical emergency most commonly seen in... more...

Related Diseases for Leukostasis

Diseases related to Leukostasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 594)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.8 VEGFA VCAM1 SERPINF1 KDR ICAM1 AGER
2 disseminated intravascular coagulation 30.2 TNF IL6 CCL2
3 leukemia, acute myeloid 30.2 VEGFA TNF MPO KDR IL6 IL1B
4 pulmonary edema 30.1 TNF IL1B ICAM1
5 macular dystrophy, dominant cystoid 30.0 VEGFA TNF IL6
6 osteonecrosis 30.0 VEGFA NFATC1 KDR
7 microvascular complications of diabetes 1 29.8 VEGFA VCAM1 SERPINF1 ICAM1 CCL2
8 neutrophilic dermatosis, acute febrile 29.8 TNF MPO IL1B
9 monocytic leukemia 29.8 TNF IL6 IL1B CCL2
10 adult respiratory distress syndrome 29.7 TNF SELL SELE MPO IL6 IL1B
11 hemorrhagic cystitis 29.7 TNF IL6 IL1B
12 fungal infectious disease 29.6 TNF IL6 IL1B
13 hyperglycemia 29.6 VCAM1 TXNIP TNF SELE IL6 AGER
14 toxic shock syndrome 29.6 TNF IL6 IL1B
15 cystitis 29.5 VEGFA TNF IL6 CCL2
16 retinal vascular disease 29.5 VEGFA TNF SERPINF1 KDR IL6 IL1B
17 acute myocardial infarction 29.5 VEGFA TNF SELE IL6
18 leukemia, acute monocytic 29.4 TNF MPO IL6 IL1B CCL2
19 acute promyelocytic leukemia 29.4 TNF MPO IL6 IL1B ICAM1
20 respiratory failure 29.4 VEGFA TNF MPO IL6 IL1B ICAM1
21 myelodysplastic syndrome 29.4 VEGFA TNF SELL MPO KDR IL6
22 stroke, ischemic 29.3 VEGFA TNF SELL IL6 IL1B
23 pulmonary hypertension 29.3 VEGFA TNF KDR IL6 CCL2
24 retinal detachment 29.3 VEGFA TNF SERPINF1 IL6 ICAM1 CCL2
25 neutropenia 29.3 TNF SELL MPO IL6 IL1B
26 pneumonia 29.2 TNF MPO IL6 IL1B CCL2
27 retinal vascular occlusion 29.2 VEGFA TNF SERPINF1 KDR IL6 ICAM1
28 ischemia 29.1 VEGFA TNF SELE MPO KDR IL6
29 acute pancreatitis 29.1 TNF MPO IL6 IL1B ICAM1 CCL2
30 uveitis 29.0 VEGFA TNF SERPINF1 IL6 IL1B ICAM1
31 macular retinal edema 28.9 VEGFA TNF SERPINF1 OCLN KDR IL6
32 thrombocytopenia 28.7 VEGFA TNF SELL SELE IL6 IL1B
33 diabetic macular edema 28.7 VEGFA TNF SERPINF1 OCLN KDR IL6
34 eye disease 28.6 VEGFA VCAM1 TNF SERPINF1 OCLN KDR
35 diabetes mellitus 28.3 VEGFA VCAM1 TXNIP TNF SELL SELE
36 lipoprotein quantitative trait locus 28.2 VEGFA VCAM1 TNF SELE MPO KDR
37 type 2 diabetes mellitus 28.0 VEGFA VCAM1 TXNIP TNF SELL SELE
38 myeloid leukemia 10.5
39 acute myeloid leukemia with recurrent genetic anomaly 10.5
40 leukemia, chronic myeloid 10.4
41 leukemia 10.4
42 acute leukemia 10.4
43 buerger disease 10.3 VEGFA VCAM1 ICAM1
44 hyperglobulinemic purpura 10.3 SELE ICAM1
45 macular degeneration, age-related, 9 10.3 VCAM1 ICAM1
46 conjunctival vascular disease 10.3 VEGFA KDR
47 chronic venous insufficiency 10.3 VCAM1 SELE ICAM1
48 heterophyiasis 10.3 SELE ICAM1
49 hydrocele 10.3 VEGFA SELE ICAM1
50 plummer's disease 10.3 SELL SELE ICAM1

Graphical network of the top 20 diseases related to Leukostasis:



Diseases related to Leukostasis

Symptoms & Phenotypes for Leukostasis

GenomeRNAi Phenotypes related to Leukostasis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.2 AGER CCL2 ICAM1 IL1B IL6 KDR
2 no effect GR00402-S-2 10.2 AGER CCL2 ICAM1 IL1B IL6 KDR

MGI Mouse Phenotypes related to Leukostasis:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.49 AGER CCL2 ICAM1 IL1B IL6 KDR
2 growth/size/body region MP:0005378 10.45 AGER CCL2 ICAM1 IL1B IL6 KDR
3 muscle MP:0005369 10.4 AGER CCL2 ICAM1 IL6 KDR MPO
4 cardiovascular system MP:0005385 10.36 AGER CCL2 ICAM1 IL1B IL6 KDR
5 immune system MP:0005387 10.36 AGER CCL2 ICAM1 IL1B IL6 KDR
6 nervous system MP:0003631 10.35 CCL2 ICAM1 IL1B IL6 KDR NFATC2
7 cellular MP:0005384 10.33 AGER CCL2 ICAM1 IL6 KDR NFATC1
8 digestive/alimentary MP:0005381 10.24 CCL2 ICAM1 IL6 NFATC1 NFATC3 NFATC4
9 endocrine/exocrine gland MP:0005379 10.21 ICAM1 IL6 NFATC2 NFATC3 NFATC4 OCLN
10 liver/biliary system MP:0005370 10.2 CCL2 IL6 KDR NFATC1 SELE SELL
11 neoplasm MP:0002006 10.18 CCL2 ICAM1 IL1B IL6 SELL TNF
12 skeleton MP:0005390 10.13 AGER CCL2 IL1B IL6 KDR NFATC1
13 hematopoietic system MP:0005397 10.11 AGER CCL2 ICAM1 IL1B IL6 KDR
14 craniofacial MP:0005382 10.08 CCL2 IL1B KDR NFATC1 NFATC2 NFATC4
15 respiratory system MP:0005388 10.02 IL6 KDR NFATC1 NFATC2 NFATC3 SELE
16 vision/eye MP:0005391 10 CCL2 ICAM1 IL6 KDR NFATC2 NFATC3
17 mortality/aging MP:0010768 9.83 CCL2 ICAM1 IL1B IL6 KDR MPO
18 integument MP:0010771 9.36 AGER CCL2 ICAM1 IL1B IL6 KDR

Drugs & Therapeutics for Leukostasis

Search Clinical Trials, NIH Clinical Center for Leukostasis

Cochrane evidence based reviews: leukostasis

Genetic Tests for Leukostasis

Anatomical Context for Leukostasis

Organs/tissues related to Leukostasis:

MalaCards : Myeloid, Bone Marrow, Endothelial, Retina, Neutrophil, Lung, Liver

Publications for Leukostasis

Articles related to Leukostasis:

(show top 50) (show all 624)
# Title Authors PMID Year
1
Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. 53 62
17653050 2007
2
Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products. 53 62
17251488 2007
3
Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. 53 62
18274606 2007
4
VEGF increases retinal vascular ICAM-1 expression in vivo. 53 62
10393052 1999
5
Hypoxic induction of interleukin-8 gene expression in human endothelial cells. 53 62
8163658 1994
6
Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. 53 62
8288963 1994
7
Endothelial activation antigens in pulmonary leukostasis in leukemia. 53 62
8237271 1993
8
Human recombinant interleukin-2 provokes acute pulmonary vascular endothelial injury in rabbits. 53 62
2160520 1990
9
[Changes in plasma granulocyte elastase, myeloperoxidase and fibronectin during and after open heart surgery]. 53 62
2157904 1990
10
CXCR3 deletion aggravates corneal neovascularization in a corneal alkali-burn model. 62
36206861 2022
11
Modulation of cGAS-STING signaling by PPARα in a mouse model of ischemia-induced retinopathy. 62
36409895 2022
12
What Is Different in Acute Hematologic Malignancy-Associated ARDS? An Overview of the Literature. 62
36143892 2022
13
Deletion of Tgfβ signal in activated microglia prolongs hypoxia-induced retinal neovascularization enhancing Igf1 expression and retinal leukostasis. 62
35611927 2022
14
Hyperleukocytosis and leukostasis in acute and chronic leukemias. 62
35357988 2022
15
Therapeutic Leukapheresis: Experience of a Single Oncologic Centre. 62
36159955 2022
16
Hematology Emergencies in Adults With Critical Illness: Malignant Hematology. 62
35167862 2022
17
Effect of cytokine-induced alterations in extracellular matrix composition on diabetic retinopathy-relevant endothelial cell behaviors. 62
35902594 2022
18
Endothelial cells: major players in acute myeloid leukaemia. 62
35148910 2022
19
Changes in Macular Perfusion After ILUVIEN® Intravitreal Implant for Diabetic Macular Edema: An OCTA Study. 62
35088300 2022
20
Leukapheresis in Pediatric Acute Leukemia with Hyperleukocytosis: A Single-Center Experience. 62
35455547 2022
21
Therapeutic Leukapheresis in Pediatric Leukemia: Utilization Trend and Early Outcomes in a US Nationwide Cohort. 62
33735152 2022
22
Management of Hyperleukocytosis in Childhood Acute Leukemia Without Leukapheresis and Rasburicase Prophylaxis. 62
34054042 2022
23
Acute leukemia presenting as acute lower limb ischemia. 62
34794339 2022
24
Leukoreductive response to the combination of sorafenib and chemotherapy in hyperleukocytosis of FLT3-ITD mutated pediatric AML. 62
36440328 2022
25
Unexplained Fatal Hyperammonemia in a Patient With New Diagnosis of Acute Monoblastic Leukemia. 62
35003956 2021
26
Sudden death due to leukostasis in a subject with undiagnosed chronic lymphocytic leukemia. 62
34415512 2021
27
Blasting Into Acute Coronary Syndrome. 62
34926059 2021
28
Light-Sheet Microscopy of the Optic Nerve Reveals Axonal Degeneration and Microglial Activation in NMDA-Induced Retinal Injury. 62
36108311 2021
29
IL-17 signaling induces iNOS+ microglia activation in retinal vascular diseases. 62
34288126 2021
30
Effect of prophylactic leukapheresis on early mortality and overall survival in acute leukemia patients with hyperleukocytosis. 62
33686785 2021
31
Evaluation of Non-infectious Pulmonary Complications in Hematological Malignancies on MDCT: Decoding Imaging Markers. 62
34744350 2021
32
Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy. 62
34643662 2021
33
Clostridium difficile Infection Complicated by Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia With Leukostasis and Sweet's Syndrome. 62
34849313 2021
34
Leukostasis retinopathy with leukemic infiltrates as onset manifestation of chronic myeloid leukemia: a case report. 62
32476461 2021
35
CD40 Expressed in Endothelial Cells Promotes Upregulation of ICAM-1 But Not Pro-Inflammatory Cytokines, NOS2 and P2X7 in the Diabetic Retina. 62
34546322 2021
36
Diabetic Retinopathy: Important Biochemical Alterations and the Main Treatment Strategies. 62
33341391 2021
37
Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes. 62
33883214 2021
38
Hemorrhagic stroke due to leukostasis in pediatric mixed-phenotype acute leukemia. 62
33986185 2021
39
Acute Myeloid Leukemia Complicated by Hyperleukocytosis and Leukostasis in the Emergency Department. 62
34094792 2021
40
High dose cyclophosphamide for cytoreduction in patients with acute myeloid leukemia with hyperleukocytosis or leukostasis. 62
33325761 2021
41
Effect of dual PPAR-α/γ agonist saroglitazar on diabetic retinopathy and oxygen-induced retinopathy. 62
33753107 2021
42
Multidisciplinary corroboration in differentiation syndrome: a case report. 62
33947461 2021
43
Aryl Hydrocarbon Receptor Agonist VAF347 Impedes Retinal Pathogenesis in Diabetic Mice. 62
33919327 2021
44
Intracranial Hemorrhage in a Pediatric Patient with Chronic Myeloid Leukemia in Chronic Phase: A Case Report. 62
33976629 2021
45
Therapeutic Potential of Tpl2 (Tumor Progression Locus 2) Inhibition on Diabetic Vasculopathy Through the Blockage of the Inflammasome Complex. 62
33176446 2021
46
Leukapheresis Does Not Improve Early Survival Outcome of Acute Myeloid Leukemia with Leukostasis Patients - A Dual-Center Retrospective Cohort Study. 62
34290537 2021
47
Post-operative hyperleukocytosis and leukostasis as the initial presentation of chronic myelomonocytic leukemia: A case report and review of literature. 62
34934616 2021
48
Hold the Chemo! Leukostasis, a Presentation of Brown Recluse Spider Bite: A Case Report. 62
34404267 2021
49
Leukapheresis and Hyperleukocytosis, Past and Future. 62
34285568 2021
50
Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study. 62
32132655 2020

Variations for Leukostasis

Expression for Leukostasis

Search GEO for disease gene expression data for Leukostasis.

Pathways for Leukostasis

Pathways related to Leukostasis according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 AGER CCL2 ICAM1 IL1B IL6 MPO
2
Show member pathways
13.64 VEGFA TNF SERPINF1 NFATC4 NFATC3 NFATC2
3
Show member pathways
13.56 CCL2 ICAM1 IL1B IL6 KDR NFATC2
4
Show member pathways
13.49 VEGFA TNF NFATC4 NFATC3 NFATC2 NFATC1
5
Show member pathways
13.34 VEGFA VCAM1 TNF IL6 IL1B ICAM1
6
Show member pathways
13.1 NFATC4 NFATC3 NFATC2 NFATC1 KDR IL6
7
Show member pathways
12.9 TNF NFATC4 NFATC3 NFATC2 NFATC1 IL6
8
Show member pathways
12.89 NFATC4 NFATC3 NFATC2 NFATC1 IL6
9
Show member pathways
12.85 SERPINF1 NFATC4 NFATC3 NFATC2 NFATC1
10
Show member pathways
12.71 CCL2 NFATC1 NFATC2 NFATC3 NFATC4
11 12.65 AGER CCL2 IL1B IL6 KDR SELE
12
Show member pathways
12.64 TNF NFATC4 NFATC3 NFATC2 NFATC1 IL6
13
Show member pathways
12.63 CCL2 IL1B IL6 MPO TNF
14
Show member pathways
12.61 NFATC4 NFATC3 NFATC2 NFATC1
15
Show member pathways
12.51 VEGFA VCAM1 OCLN KDR ICAM1 CCL2
16 12.46 NFATC4 NFATC3 NFATC2 NFATC1
17
Show member pathways
12.46 IL1B NFATC1 NFATC2 NFATC3
18 12.44 TNF NFATC3 NFATC1 IL1B
19
Show member pathways
12.43 VEGFA VCAM1 SELE NFATC1 KDR ICAM1
20
Show member pathways
12.3 NFATC4 NFATC3 NFATC2 NFATC1
21
Show member pathways
12.29 NFATC4 NFATC3 NFATC2 NFATC1
22 12.21 VEGFA TNF IL6 IL1B
23 12.17 VCAM1 TNF NFATC4 NFATC3 NFATC2 NFATC1
24 12.12 VEGFA VCAM1 KDR IL6
25 12.04 TNF SELL MPO IL6
26 12.04 CCL2 ICAM1 IL1B IL6 TNF
27 11.93 CCL2 IL6 VCAM1 VEGFA
28 11.9 VEGFA TNF IL1B
29 11.83 SERPINF1 NFATC1 IL6
30 11.83 CCL2 ICAM1 IL1B IL6 TNF VCAM1
31
Show member pathways
11.81 NFATC3 NFATC2 NFATC1
32 11.81 TNF SELL IL6 IL1B
33 11.81 SELE NFATC2 NFATC1 IL6 ICAM1
34 11.77 IL6 SELL TNF
35
Show member pathways
11.77 CCL2 IL6 VEGFA
36 11.75 NFATC1 IL6 IL1B
37 11.75 NFATC2 IL6 CCL2
38
Show member pathways
11.74 TNF NFATC2 NFATC1
39 11.73 CCL2 IL1B IL6 TNF
40 11.72 VCAM1 TNF IL6 ICAM1
41 11.72 VEGFA TNF IL6 IL1B ICAM1 CCL2
42 11.7 TNF IL6 IL1B
43
Show member pathways
11.68 TNF NFATC1 IL6
44
Show member pathways
11.67 NFATC4 NFATC3 NFATC2 NFATC1
45 11.63 VEGFA KDR IL6
46 11.61 TNF IL6 CCL2
47 11.61 NFATC1 NFATC2 NFATC3 NFATC4
48 11.61 NFATC4 NFATC3 NFATC2 NFATC1
49 11.61 NFATC1 NFATC2 NFATC3 NFATC4 TNF
50 11.57 TNF IL1B CCL2

GO Terms for Leukostasis

Cellular components related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.64 VCAM1 TNF SELL SELE KDR ICAM1
2 plasma membrane GO:0005887 9.64 VCAM1 TNF SELL SELE KDR ICAM1

Biological processes related to Leukostasis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 10.3 VEGFA TNF KDR IL1B AGER
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.22 VEGFA TNF KDR ICAM1 CCL2 AGER
3 inflammatory response GO:0006954 10.22 AGER CCL2 IL1B IL6 NFATC3 NFATC4
4 positive regulation of interleukin-6 production GO:0032755 10.21 TNF IL6 IL1B AGER
5 response to lipopolysaccharide GO:0032496 10.21 VCAM1 TNF SELE MPO IL1B
6 regulation of insulin secretion GO:0050796 10.13 TNF IL6 IL1B
7 protein kinase B signaling GO:0043491 10.13 TNF KDR IL1B CCL2
8 lipopolysaccharide-mediated signaling pathway GO:0031663 10.11 CCL2 IL1B TNF
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 10.1 VEGFA VCAM1 KDR
10 cellular response to amyloid-beta GO:1904646 10.1 AGER ICAM1 TNF VCAM1
11 branching involved in blood vessel morphogenesis GO:0001569 10.09 VEGFA NFATC4 KDR
12 positive regulation of p38MAPK cascade GO:1900745 10.08 AGER IL1B VEGFA
13 negative regulation of neurogenesis GO:0050768 10.06 TNF IL6 IL1B
14 positive regulation of chemokine production GO:0032722 10.05 TNF IL6 IL1B AGER
15 positive regulation of glial cell proliferation GO:0060252 10.04 TNF IL6 IL1B
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.02 TNF IL1B AGER
17 astrocyte activation GO:0048143 10.01 AGER IL1B TNF
18 leukocyte cell-cell adhesion GO:0007159 9.97 VCAM1 SELL SELE ICAM1
19 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.95 VEGFA KDR
20 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.95 VEGFA KDR
21 positive regulation of fever generation GO:0031622 9.94 TNF IL1B
22 membrane to membrane docking GO:0022614 9.94 VCAM1 ICAM1
23 sequestering of triglyceride GO:0030730 9.93 TNF IL1B
24 positive regulation of neuroinflammatory response GO:0150078 9.93 TNF IL6 IL1B
25 vascular endothelial growth factor production GO:0010573 9.91 IL1B IL6 TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.89 TNF IL1B
27 response to gold nanoparticle GO:1990268 9.88 MPO TNF
28 negative regulation of vascular associated smooth muscle cell differentiation GO:1905064 9.88 NFATC1 NFATC2 NFATC3
29 leukocyte tethering or rolling GO:0050901 9.86 VCAM1 TNF SELL SELE
30 calcineurin-NFAT signaling cascade GO:0033173 9.76 NFATC4 NFATC3 NFATC2 NFATC1
31 leukocyte migration GO:0050900 9.43 TNF SELL SELE IL1B ICAM1
32 cytokine production GO:0001816 8.92 NFATC4 NFATC3 NFATC2 NFATC1

Molecular functions related to Leukostasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.61 VEGFA TNF IL6 IL1B CCL2
2 transcription factor binding GO:0008134 8.92 NFATC4 NFATC3 NFATC2 NFATC1

Sources for Leukostasis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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