MCID: LWS001
MIFTS: 20

Lewis-Sumner Syndrome

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Lewis-Sumner Syndrome

MalaCards integrated aliases for Lewis-Sumner Syndrome:

Name: Lewis-Sumner Syndrome 52 58
Multifocal Acquired Demyelinating Sensory and Motor Neuropathy 52 58
Madsam 52 58

Characteristics:

Orphanet epidemiological data:

58
lewis-sumner syndrome
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 33 G61.8
UMLS via Orphanet 72 C1695985
Orphanet 58 ORPHA48162

Summaries for Lewis-Sumner Syndrome

NIH Rare Diseases : 52 Lewis-Sumner syndrome (also known as multifocal acquired demyelinating sensory and motor neuropathy) is a neurological condition affecting primarily the arms and hands (upper limbs). The symptoms are a result of inflammation of the nerves leading to the upper body and the destruction of the fatty covering that protects the nerves (myelin sheath ). Lewis Sumner syndrome is an acquired disorder, and the exact cause of the condition is not known. Lewis Sumner syndrome may be difficult to distinguish from other forms of demyelinating neuropathies , but diagnosis may be possible through nerve conduction studies or a specific type of imaging test, called MRI with T2 STIR . Treatment with intravenous immunoglobulin (IVIg) therapy has been successful in reducing the symptoms of the disease.

MalaCards based summary : Lewis-Sumner Syndrome, also known as multifocal acquired demyelinating sensory and motor neuropathy, is related to neuropathy and multifocal motor neuropathy. Affiliated tissues include testes and tongue.

Wikipedia : 74 Chronic inflammatory demyelinating polyneuropathy is an acquired immune-mediated inflammatory disorder... more...

Related Diseases for Lewis-Sumner Syndrome

Diseases related to Lewis-Sumner Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 neuropathy 10.8
2 multifocal motor neuropathy 10.7
3 chronic inflammatory demyelinating polyradiculoneuropathy 10.7
4 polyneuropathy 10.6
5 demyelinating polyneuropathy 10.6
6 polyradiculoneuropathy 10.6
7 motor neuron disease 10.4
8 rheumatoid arthritis 10.4
9 peripheral nervous system disease 10.4
10 arthritis 10.4
11 amyotrophic lateral sclerosis 1 10.2
12 orthostatic intolerance 10.2
13 ulnar nerve lesion 10.2
14 lumbosacral plexus lesion 10.2
15 lateral sclerosis 10.2
16 neurofibroma 10.2
17 alopecia 10.2
18 dysautonomia 10.2
19 syncope 10.2
20 myositis 10.2
21 tangier disease 10.2
22 arachnoid cysts, intracranial 10.2
23 hepatitis c virus 10.2
24 colitis 10.2
25 mononeuropathy 10.2
26 rheumatic disease 10.2
27 hepatitis c 10.2
28 enthesopathy 10.2
29 progressive muscular atrophy 10.2
30 myopathy 10.2
31 pustulosis of palm and sole 10.2
32 muscular atrophy 10.2
33 ulcerative colitis 10.2
34 psoriasis 10.2
35 paresthesia 10.2
36 focal myositis 10.2
37 west nile virus 10.1
38 ulnar neuropathy 10.1
39 chronic acquired demyelinating polyneuropathy 10.1

Graphical network of the top 20 diseases related to Lewis-Sumner Syndrome:



Diseases related to Lewis-Sumner Syndrome

Symptoms & Phenotypes for Lewis-Sumner Syndrome

Drugs & Therapeutics for Lewis-Sumner Syndrome

Search Clinical Trials , NIH Clinical Center for Lewis-Sumner Syndrome

Genetic Tests for Lewis-Sumner Syndrome

Anatomical Context for Lewis-Sumner Syndrome

MalaCards organs/tissues related to Lewis-Sumner Syndrome:

40
Testes, Tongue

Publications for Lewis-Sumner Syndrome

Articles related to Lewis-Sumner Syndrome:

(show top 50) (show all 96)
# Title Authors PMID Year
1
Prospective study of the additional benefit of plexus magnetic resonance imaging in the diagnosis of chronic inflammatory demyelinating polyneuropathy. 61
31348848 2020
2
Comparison of Lewis-Sumner syndrome with chronic inflammatory demyelinating polyradiculoneuropathy patients in a tertiary care centre. 61
31574194 2019
3
Chronic inflammatory demyelinating polyneuropathy: update on diagnosis, immunopathogenesis and treatment. 61
30992333 2019
4
Motor conduction block and conduction velocity in Lewis-Sumner syndrome and multifocal motor neuropathy. 61
31272830 2019
5
Multifocal nodular hypertrophy of trigeminal nerve in multifocal acquired demyelinating sensory and motor neuropathy. 61
31089480 2019
6
Increased IP-10 production by blood-nerve barrier in multifocal acquired demyelinating sensory and motor neuropathy and multifocal motor neuropathy. 61
30523038 2019
7
Clinical Features of Lewis-Sumner Syndrome: Can Trauma Precipitate Symptoms? 61
30724154 2019
8
Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database. 61
30297520 2019
9
Chronic Inflammatory Demyelinating Polyneuropathy. 61
31760654 2019
10
Anti-neutral glycolipids antibody-positive combined central and peripheral demyelination mimicking encephalomyeloradiculoneuropathy phenotype. 61
29986202 2018
11
Hypoglossal nerve involvement in Lewis-Sumner syndrome: a case report. 61
29511978 2018
12
Extremely Painful Multifocal Acquired Predominant Axonal Sensorimotor Neuropathy of the Upper Limb. 61
29159899 2018
13
Lewis-Sumner Syndrome Manifesting as Unilateral Vocal Fold Paresis and Laryngeal Fasciculations. 61
28781097 2018
14
Home versus hospital immunoglobulin treatment for autoimmune neuropathies: A cost minimization analysis. 61
29484273 2018
15
High-resolution ultrasound in patients with Wartenberg's migrant sensory neuritis, a case-control study. 61
29202391 2018
16
Ultrasound and MRI of nerves for monitoring disease activity and treatment effects in chronic dysimmune neuropathies - Current concepts and future directions. 61
29190522 2018
17
[About a Case of Lewis-Sumner Syndrome Observed in Niger]. 61
30950592 2018
18
Hemiatrophy of the Tongue with Contralateral Hemiparesis in a Patient with Multifocal Acquired Demyelinating Sensory and Motor Neuropathy. 61
28831789 2017
19
Lewis-Sumner syndrome in a patient with rheumatoid arthritis: Link between rheumatoid arthritis and demyelinating polyradiculoneuropathies. 61
28363822 2017
20
Asymmetric sensory nerve action potential amplitudes as an early hint for diagnosing Lewis-Sumner syndrome. 61
27709506 2017
21
Brachial plexus magnetic resonance imaging differentiates between inflammatory neuropathies and does not predict disease course. 61
28523213 2017
22
Lewis-Sumner syndrome associated with infliximab therapy for psoriasis. 61
28225983 2017
23
Diagnostic value of sonography in treatment-naive chronic inflammatory neuropathies. 61
27927940 2017
24
Case Report of Lewis and Sumner Syndrome with Bilateral Vagus Nerves Paralysis for 16 Years. 61
27175564 2016
25
Multifocal Acquired Demyelinating Sensory and Motor Neuropathy: Unexpected Diagnosis After Ultrasound Imaging for a Humeral Fracture. 61
27088473 2016
26
Nerve ultrasound protocol in differentiating chronic immune-mediated neuropathies. 61
27061901 2016
27
Normalization of sonographical multifocal nerve enlargements in a MADSAM patient following a good clinical response to intravenous immunoglobulin. 61
27460345 2016
28
Lewis-Sumner syndrome associated with infliximab therapy in ulcerative colitis. 61
26838522 2016
29
[Clinical and electrophysiological characteristics and therapeutic analysis of 9 patients with Lewis-Sumner syndrome]. 61
27045647 2016
30
Ultrasonography of Multifocal Acquired Demyelinating Sensory and Motor Neuropathy (MADSAM). 61
25556187 2015
31
Precise correlation between structural and electrophysiological disturbances in MADSAM neuropathy. 61
26314279 2015
32
Different electrophysiological profiles and treatment response in 'typical' and 'atypical' chronic inflammatory demyelinating polyneuropathy. 61
25424435 2015
33
Reconstruction magnetic resonance neurography in chronic inflammatory demyelinating polyneuropathy. 61
25425460 2015
34
Serum cytokine and chemokine profiles in patients with chronic inflammatory demyelinating polyneuropathy. 61
25669993 2015
35
Bochum ultrasound score allows distinction of chronic inflammatory from multifocal acquired demyelinating polyneuropathies. 61
25534358 2015
36
Nerve biopsy findings contribute to diagnosis of multiple mononeuropathy: 78% of findings support clinical diagnosis. 61
25788930 2015
37
Diagnostic value of MR imaging in the Lewis-Sumner syndrome: a case series. 61
24825730 2014
38
Chronic inflammatory demyelinating polyradiculoneuropathy and variants: where we are and where we should go. 61
24612201 2014
39
HCV-related central and peripheral nervous system demyelinating disorders. 61
25198705 2014
40
Severity and patterns of blood-nerve barrier breakdown in patients with chronic inflammatory demyelinating polyradiculoneuropathy: correlations with clinical subtypes. 61
25105500 2014
41
[A case of multifocal acquired demyelinating sensory and motor neuropathy with whole body alopecia]. 61
24990836 2014
42
Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. 61
23642723 2013
43
[Neurological complications during treatment of the tumor necrosis alpha inhibitors]. 61
23894783 2013
44
Long-term treatment of Lewis-Sumner syndrome with subcutaneous immunoglobulin infusions. 61
23095259 2013
45
Multifocal acquired demyelinating sensory and motor neuropathy. 61
23071167 2012
46
Orthostatic intolerance in multifocal acquired demyelinating sensory and motor neuropathy. 61
22922580 2012
47
Ultrasonography of MADSAM neuropathy: focal nerve enlargements at sites of existing and resolved conduction blocks. 61
22513319 2012
48
Clinical and electrophysiological characteristics of neuropathy associated with Tangier disease. 61
22179783 2012
49
[Diagnosis of immune-mediated neuropathies]. 61
21920842 2011
50
Response to treatment in patients with Lewis-Sumner syndrome. 61
21755505 2011

Variations for Lewis-Sumner Syndrome

Expression for Lewis-Sumner Syndrome

Search GEO for disease gene expression data for Lewis-Sumner Syndrome.

Pathways for Lewis-Sumner Syndrome

GO Terms for Lewis-Sumner Syndrome

Sources for Lewis-Sumner Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....