MCID: LWS001
MIFTS: 19

Lewis-Sumner Syndrome

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Lewis-Sumner Syndrome

MalaCards integrated aliases for Lewis-Sumner Syndrome:

Name: Lewis-Sumner Syndrome 53 59
Multifocal Acquired Demyelinating Sensory and Motor Neuropathy 53 59
Madsam 53 59

Characteristics:

Orphanet epidemiological data:

59
lewis-sumner syndrome
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA48162
UMLS via Orphanet 74 C1695985
ICD10 via Orphanet 34 G61.8

Summaries for Lewis-Sumner Syndrome

NIH Rare Diseases : 53 Lewis-Sumner syndrome (also known as multifocal acquired demyelinating sensory and motor neuropathy) is a neurological condition affecting primarily the arms and hands (upper limbs). The symptoms are a result of inflammation of the nerves leading to the upper body and the destruction of the fatty covering that protects the nerves (myelin sheath). Lewis Sumner syndrome is an acquired disorder, and the exact cause of the condition is not known. Lewis Sumner syndrome may be difficult to distinguish from other forms of demyelinating neuropathies, but diagnosis may be possible through nerve conduction studies or a specific type of imaging test, called MRI with T2 STIR. Treatment with intravenous immunoglobulin (IVIg) therapy has been successful in reducing the symptoms of the disease.

MalaCards based summary : Lewis-Sumner Syndrome, also known as multifocal acquired demyelinating sensory and motor neuropathy, is related to chronic inflammatory demyelinating polyneuropathy and neuropathy. Affiliated tissues include testes.

Wikipedia : 76 Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated inflammatory... more...

Related Diseases for Lewis-Sumner Syndrome

Diseases related to Lewis-Sumner Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 chronic inflammatory demyelinating polyneuropathy 11.6
2 neuropathy 10.5
3 multifocal motor neuropathy 10.4
4 rheumatoid arthritis 10.2
5 arthritis 10.2
6 polyradiculoneuropathy 10.2
7 tangier disease 10.0
8 hepatitis c virus 10.0
9 hepatitis 10.0
10 motor neuron disease 10.0
11 ulcerative colitis 10.0
12 colitis 10.0
13 polyneuropathy 10.0
14 hepatitis c 10.0
15 laryngitis 10.0
16 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
17 demyelinating polyneuropathy 10.0
18 neuronitis 10.0
19 psoriasis 10.0

Graphical network of the top 20 diseases related to Lewis-Sumner Syndrome:



Diseases related to Lewis-Sumner Syndrome

Symptoms & Phenotypes for Lewis-Sumner Syndrome

Drugs & Therapeutics for Lewis-Sumner Syndrome

Search Clinical Trials , NIH Clinical Center for Lewis-Sumner Syndrome

Genetic Tests for Lewis-Sumner Syndrome

Anatomical Context for Lewis-Sumner Syndrome

MalaCards organs/tissues related to Lewis-Sumner Syndrome:

41
Testes

Publications for Lewis-Sumner Syndrome

Articles related to Lewis-Sumner Syndrome:

(show all 30)
# Title Authors Year
1
Hypoglossal nerve involvement in Lewis-Sumner syndrome: a case report. ( 29511978 )
2018
2
Lewis-Sumner syndrome in a patient with rheumatoid arthritis: Link between rheumatoid arthritis and demyelinating polyradiculoneuropathies. ( 28363822 )
2017
3
Lewis-Sumner syndrome associated with infliximab therapy for psoriasis. ( 28225983 )
2017
4
Lewis-Sumner Syndrome Manifesting as Unilateral Vocal Fold Paresis and Laryngeal Fasciculations. ( 28781097 )
2017
5
Lewis-Sumner syndrome associated with infliximab therapy in ulcerative colitis. ( 26838522 )
2016
6
Asymmetric sensory nerve action potential amplitudes as an early hint for diagnosing Lewis-Sumner syndrome. ( 27709506 )
2016
7
Chronic inflammatory demyelinating polyneuropathy variant (Lewis- Sumner syndrome) in HIV. ( 27727849 )
2016
8
Diagnostic value of MR imaging in the Lewis-Sumner syndrome: a case series. ( 24825730 )
2014
9
Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants. ( 23642723 )
2013
10
Long-term treatment of Lewis-Sumner syndrome with subcutaneous immunoglobulin infusions. ( 23095259 )
2013
11
Orthostatic intolerance in multifocal acquired demyelinating sensory and motor neuropathy. ( 22922580 )
2012
12
Motor root conduction block in the Lewis-Sumner syndrome. ( 21321496 )
2011
13
Response to treatment in patients with Lewis-Sumner syndrome. ( 21755505 )
2011
14
Treatment of chronic immune-mediated neuropathies: chronic inflammatory demyelinating polyradiculoneuropathy, multifocal motor neuropathy, and the Lewis-Sumner syndrome. ( 20941678 )
2010
15
A case of Lewis-Sumner syndrome showing dramatic improvement after plasma exchange. ( 20592909 )
2010
16
Lewis-sumner syndrome of pure upper-limb onset: diagnostic, prognostic, and therapeutic features. ( 19145651 )
2009
17
Lewis-Sumner syndrome and Tangier disease. ( 18625867 )
2008
18
Lewis-Sumner syndrome associated with infliximab therapy in rheumatoid arthritis. ( 18671292 )
2008
19
Hypoglossal neuropathy in Lewis-Sumner syndrome masquerading as motor neuron disease. ( 16832106 )
2006
20
Lewis-Sumner syndrome in hepatitis C virus infection: a possible pathogenetic association with therapeutic problems. ( 16453326 )
2006
21
Bilateral ulnar neuropathy due to multifocal acquired demyelinating sensory and motor neuropathy (MADSAM). ( 16875765 )
2006
22
A case of Lewis-Sumner syndrome with conduction abnormalities only in the brachial plexus and roots. ( 16609975 )
2006
23
Lewis-Sumner syndrome and multifocal motor neuropathy. ( 15536613 )
2005
24
Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome. ( 15289267 )
2004
25
Massive peripheral nerve hypertrophy in a patient with multifocal upper limb demyelinating neuropathy (Lewis-Sumner syndrome). ( 11851033 )
2001
26
Multifocal motor neuropathy and Lewis Sumner syndrome: two distinct entities. ( 10567092 )
1999
27
Are multifocal motor neuropathy and Lewis-Sumner syndrome distinct nosologic entities? ( 10331352 )
1999
28
Multifocal motor neuropathy and Lewis Sumner syndrome: a clinical spectrum. ( 10567093 )
1999
29
Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome. ( 10331353 )
1999
30
Chronic multifocal neuropathy with persistent conduction block (Lewis-Sumner syndrome). A clinico-morphologic study of two further cases with review of the literature. ( 8287628 )
1993

Variations for Lewis-Sumner Syndrome

Expression for Lewis-Sumner Syndrome

Search GEO for disease gene expression data for Lewis-Sumner Syndrome.

Pathways for Lewis-Sumner Syndrome

GO Terms for Lewis-Sumner Syndrome

Sources for Lewis-Sumner Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....