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MCID: LYD001
MIFTS: 47

Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Leydig Cell Tumor

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MalaCards integrated aliases for Leydig Cell Tumor:

Name: Leydig Cell Tumor 12 56 45 15 17 74
Leydig Cell Tumor, Benign 74
Leydig Cell Neoplasm 12
Tumor, Leydig Cell 41

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2696
MeSH 45 D007984
NCIt 51 C3188
SNOMED-CT 69 45002009
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Summaries for Leydig Cell Tumor

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MalaCards based summary : Leydig Cell Tumor, also known as leydig cell tumor, benign, is related to sertoli-leydig cell tumor and testicular leydig cell tumor. An important gene associated with Leydig Cell Tumor is LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Glucose / Energy Metabolism. The drugs Testosterone undecanoate and Testosterone enanthate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and breast, and related phenotypes are endocrine/exocrine gland and behavior/neurological

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Related Diseases for Leydig Cell Tumor

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Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 sertoli-leydig cell tumor 34.5 AFP INSL3
2 testicular leydig cell tumor 32.9 CYP11A1 CYP17A1 CYP21A2 STAR
3 hyperandrogenism 30.3 CYP17A1 CYP19A1 CYP21A2
4 precocious puberty 30.3 CYP19A1 CYP21A2 LHCGR
5 sex cord-gonadal stromal tumor 30.1 AFP CYP19A1 INHA
6 infertility 29.8 CYP19A1 INHA INSL3 LHCGR
7 dysgerminoma 29.8 AFP PTHLH
8 adrenal adenoma 29.6 CYP11A1 CYP17A1 CYP21A2
9 conn's syndrome 29.6 CYP11A1 CYP17A1 CYP21A2
10 lipoid congenital adrenal hyperplasia 29.3 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR
11 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.8
12 malignant leydig cell tumor 12.5
13 malignant sertoli-leydig cell tumor of the ovary 12.5
14 malignant testicular leydig cell tumor 12.3
15 malignant sertoli-leydig cell tumor 12.3
16 gynecomastia 10.5
17 infant gynecomastia 10.4
18 androgen insensitivity syndrome 10.3
19 rhabdomyosarcoma 10.3
20 testotoxicosis 10.2 CYP19A1 LHCGR
21 complete androgen insensitivity syndrome 10.2
22 pseudovaginal perineoscrotal hypospadias 10.2 CYP17A1 LHCGR
23 orofaciodigital syndrome viii 10.2 AFP INHA
24 precocious puberty, male-limited 10.2 CYP19A1 LHCGR
25 cystadenofibroma 10.2 AFP INHA
26 cryptorchidism, unilateral or bilateral 10.2
27 multinodular goiter 10.2
28 sarcoma 10.2
29 goiter 10.2
30 male reproductive organ benign neoplasm 10.2 AFP CYP19A1
31 reproductive organ benign neoplasm 10.2 AFP CYP19A1
32 mammographic density 10.2 CYP17A1 CYP19A1
33 cytochrome p450 oxidoreductase deficiency 10.1 CYP17A1 CYP21A2
34 amenorrhea 10.1
35 azoospermia 10.1
36 adrenal rest tumor 10.1
37 cystadenoma 10.1
38 adenocarcinoma 10.1
39 teratoma 10.1
40 sclerosing hepatic carcinoma 10.1 AFP PTHLH
41 ovarian small cell carcinoma 10.1 INHA PTHLH
42 liver sarcoma 10.1 AFP PTHLH
43 mycetoma 10.1 CYP17A1 CYP19A1
44 alopecia, androgenetic, 1 10.1 CYP19A1 CYP21A2
45 chorioangioma 10.1 AFP PTHLH
46 acute adrenal insufficiency 10.1 CYP11A1 CYP21A2
47 testicular disease 10.1 AFP INSL3
48 gonadal disease 10.0 AFP CYP19A1 LHCGR
49 prostate cancer 10.0
50 prostate cancer, hereditary, 8 10.0

Graphical network of the top 20 diseases related to Leydig Cell Tumor:



Diseases related to Leydig Cell Tumor
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Symptoms & Phenotypes for Leydig Cell Tumor

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MGI Mouse Phenotypes related to Leydig Cell Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 AFP CYP11A1 CYP19A1 INHA INSL3 LHCGR
2 behavior/neurological MP:0005386 9.95 AFP CYP11A1 CYP17A1 CYP19A1 INSL3 LHCGR
3 growth/size/body region MP:0005378 9.87 CYP11A1 CYP17A1 CYP19A1 INHA LHCGR PTHLH
4 homeostasis/metabolism MP:0005376 9.86 AFP CYP11A1 CYP17A1 CYP19A1 INHA LHCGR
5 liver/biliary system MP:0005370 9.63 AFP CYP11A1 CYP19A1 INHA LHCGR PTHLH
6 reproductive system MP:0005389 9.61 AFP CYP11A1 CYP17A1 CYP19A1 INHA INSL3
7 skeleton MP:0005390 9.02 CYP17A1 CYP19A1 INHA INSL3 PTHLH
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Drugs & Therapeutics for Leydig Cell Tumor

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Drugs for Leydig Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
2
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
3
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
4
Testosterone Approved, Experimental, Investigational Phase 2, Phase 3 58-22-0, 481-30-1 10204 6013
5
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 8001-79-4
6 Antineoplastic Agents, Hormonal Phase 2, Phase 3
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
8 Testosterone 17 beta-cypionate Phase 2, Phase 3
9 Anabolic Agents Phase 2, Phase 3
10 Laxatives Phase 2, Phase 3
11 Androgens Phase 2, Phase 3
12 Castor Phase 2, Phase 3
13 Cathartics Phase 2, Phase 3
14 Gastrointestinal Agents Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Hormone Antagonists Phase 2, Phase 3
17
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
18
Bevacizumab Approved, Investigational Phase 2 216974-75-3
19
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
20
Etoposide Approved Phase 2 33419-42-0 36462
21
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
22
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
23
nivolumab Approved Phase 2 946414-94-4
24
Ipilimumab Approved Phase 2 477202-00-9
25 Antineoplastic Agents, Phytogenic Phase 2
26 Albumin-Bound Paclitaxel Phase 2
27 Antimitotic Agents Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Immunoglobulin G Phase 2
30 Antibodies Phase 2
31 Immunologic Factors Phase 2,Phase 1
32 Antineoplastic Agents, Immunological Phase 2
33 Antibodies, Monoclonal Phase 2
34 Angiogenesis Modulating Agents Phase 2
35 Immunoglobulins Phase 2
36 Endothelial Growth Factors Phase 2
37 Mitogens Phase 2
38 Anti-Bacterial Agents Phase 2
39 Topoisomerase Inhibitors Phase 2
40 Etoposide phosphate Phase 2
41 Antibiotics, Antitubercular Phase 2
42
Gemcitabine Approved Phase 1 95058-81-4 60750
43 Antimetabolites Phase 1
44 Anti-Infective Agents Phase 1
45 Immunosuppressive Agents Phase 1
46 Antimetabolites, Antineoplastic Phase 1
47 Antiviral Agents Phase 1
48
Dactinomycin Approved, Investigational 50-76-0 457193 2019
49
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
50
Ifosfamide Approved 3778-73-2 3690

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
2 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
4 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
5 Cabozantinib in Combination With Nivolumab and Ipilimumab in Rare Genitourinary Tumors Recruiting NCT03866382 Phase 2 Cabozantinib;Cabozantinib S-malate
6 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
7 Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors Completed NCT01572467
8 Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer Completed NCT01764789 Not Applicable
9 DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597
10 International PPB Registry for PPB, DICER1 and Associated Conditions Recruiting NCT03382158
11 Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome Active, not recruiting NCT00565903

Search NIH Clinical Center for Leydig Cell Tumor

Cochrane evidence based reviews: leydig cell tumor

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Genetic Tests for Leydig Cell Tumor

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Anatomical Context for Leydig Cell Tumor

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MalaCards organs/tissues related to Leydig Cell Tumor:

42
Ovary, Testis, Breast, Prostate, Endothelial, Lung, Bone
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Publications for Leydig Cell Tumor

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Articles related to Leydig Cell Tumor:

(show top 50) (show all 381)
# Title Authors Year
1
A Multicenter Retrospective Review of Pediatric Leydig Cell Tumor of the Testis. ( 29554024 )
2019
2
Sertoli-Leydig Cell Tumor of Ovary: A Rare Case Report with Heterologous Elements and Focal Marked Anaplasia. ( 30820423 )
2019
3
Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report. ( 30935425 )
2019
4
Sertoli-Leydig cell tumor of the ovary: Analysis of a single institution database and review of the literature. ( 31106943 )
2019
5
Two Years of Gynecomastia Caused by Leydig Cell Tumor. ( 30112247 )
2018
6
An ovarian Leydig cell tumor of ultrasound negative in a postmenopausal woman with hirsutism and hyperandrogenism: A case report. ( 29517680 )
2018
7
Testicular Estrogen-Secreting Leydig Cell Tumor in 18F-FDG PET/CT: An Incidental Detection in a Patient Treated by Chemotherapy for Hodgkin Lymphoma. ( 29166332 )
2018
8
Mitotane treatment in patients with metastatic testicular Leydig cell tumor associated with severe androgen excess. ( 29330226 )
2018
9
Case report: an identical twin with Sertoli-Leydig cell tumor. ( 29366348 )
2018
10
Retroperitoneal Leydig cell tumor recurrence presenting 14 years after orchiectomy. ( 29524977 )
2018
11
Ovarian Sertoli-Leydig Cell Tumor With Heterologous Hepatocytes and a Hepatocellular Carcinomatous Element. ( 29620585 )
2018
12
Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis. ( 29670803 )
2018
13
Poorly differentiated, ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcoma and glandular elements: Diagnosis and management of a rare neoplasm. ( 29922708 )
2018
14
Management of testicular Leydig cell tumor: A case report. ( 29924022 )
2018
15
Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome. ( 30014022 )
2018
16
Frozen Section Diagnostic Pitfalls of Sertoli-Leydig Cell Tumor with Heterologous Elements. ( 30147979 )
2018
17
Leydig cell tumor in an Amur tiger (Panthera tigris altaica). ( 30541983 )
2018
18
Ovarian Sertoli-Leydig Cell Tumor with Elevated Inhibin B as a Cause of Secondary Amenorrhea in an Adolescent with Germ Line DICER1 Mutation. ( 28502826 )
2017
19
Leydig cell tumor of the testis, presenting with azoospermia. ( 29259494 )
2017
20
A Case Report: Ovarian Sertoli-Leydig Cell Tumor With Hyperestrogenism and Endometrial Hyperplasia in a Postmenopausal Woman. ( 28469526 )
2017
21
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
22
An inguinal hernia with cryptorchidism with a Leydig cell tumor in an elderly man: A case report. ( 28171846 )
2017
23
Leydig cell tumor in the post-menopausal woman: case report and literature review. ( 28112699 )
2017
24
Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature. ( 28316852 )
2017
25
Leydig cell tumor in grey zone: A case report. ( 28419904 )
2017
26
Incidental Leydig Cell Tumor in Patient with Hormone Resistant Prostate Cancer. ( 28443242 )
2017
27
Leydig cell tumor in ovary of a German Shepherd bitch: An immunohistopathological study. ( 28473902 )
2017
28
Leydig Cell Tumor of Testis in a Child: An Uncommon Presentation. ( 28694581 )
2017
29
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature. ( 28751916 )
2017
30
Sertoli-Leydig cell tumor of the ovary masquerading as a mucinous adenocarcinoma: a frozen section pitfall. ( 29081925 )
2017
31
Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report. ( 27833751 )
2016
32
A Rare Case of Intra-Endometrial Leiomyoma of Uterus Simulating Degenerated Submucosal Leiomyoma Accompanied by a Large Sertoli-Leydig Cell Tumor. ( 26847310 )
2016
33
Leydig cell tumor found incidentally during microscopic testicular sperm extraction in patient with mosaic Klinefelter syndrome: case report. ( 27523297 )
2016
34
Atypical Leydig Cell Tumor in Children: Report of 2 Cases. ( 27940757 )
2016
35
Recurrent ovarian Sertoli-Leydig cell tumor in a child with Peutz-Jeghers syndrome. ( 28101370 )
2016
36
Large moderately-differentiated ovarian Sertoli-Leydig cell tumor in a 13-year-old female: A case report. ( 26893701 )
2016
37
Sertoli-Leydig cell tumor of the ovary: A diagnostic dilemma. ( 26937481 )
2016
38
The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome. ( 26983701 )
2016
39
Ovarian Sertoli-Leydig cell tumor with heterologous elements containing an unusual type of alpha-fetoprotein-producing cells. ( 27126717 )
2016
40
Recurrent Sertoli-Leydig cell tumor of ovary in 8-year-old girl. ( 27334531 )
2016
41
Fertility-sparing management and obstetric outcomes in a 20-year-old patient with a Sertoli-Leydig cell tumor of the ovary: A case report and review of the literature. ( 27446397 )
2016
42
Sertoli - Leydig cell tumor with retiform areas and overgrowth of rhabdomyosarcomatous elements: case report and literature review. ( 27473538 )
2016
43
Alopecia and hirsutism in a postmenopausal woman as the presenting complaint of ovarian hilus (Leydig) cell tumor. ( 25910403 )
2015
44
Cervical embryonal rhabdomyosarcoma and ovarian Sertoli-Leydig cell tumor with congenital absence of unilateral ovary. ( 26458643 )
2015
45
Leydig cell tumor incidentally detected by fused FDG-PET/MRI. ( 25636443 )
2015
46
Ovarian Sertoli-Leydig Cell Tumor with Predominant Heterologous Mucinous Differentiation and Foci of Hepatocytic Differentiation: Case Report and Review of The Literature. ( 26116602 )
2015
47
Leydig cell tumor in a patient with 49,XXXXY karyotype: a review of literature. ( 26160035 )
2015
48
Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation. ( 26525589 )
2015
49
True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review. ( 26579503 )
2015
50
Leydig cell tumor with lung metastasis diagnosed by lung biopsy. ( 26722493 )
2015
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Variations for Leydig Cell Tumor

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Expression for Leydig Cell Tumor

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Search GEO for disease gene expression data for Leydig Cell Tumor.
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Pathways for Leydig Cell Tumor

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Pathways related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 38
Show member pathways
 12.6 CYP11A1 CYP17A1 CYP21A2 STAR
2
Glucose / Energy Metabolism 4
12.11 CYP11A1 CYP17A1 CYP19A1 STAR
3
G alpha (s) signalling events 67
11.74 INSL3 LHCGR PTHLH
4
Corticotropin-releasing hormone signaling pathway 1
11.51 CYP11A1 CYP21A2 STAR
5
Metabolism of steroid hormones 67
Show member pathways
 11.3 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR
6
Steroid hormone biosynthesis 38
Show member pathways
 11.28 CYP11A1 CYP17A1 CYP19A1 CYP21A2
7
Androstenedione and testosterone biosynthesis and metabolism p.1 23
Show member pathways
 11.21 CYP17A1 CYP19A1
8
Ovarian Infertility Genes 1
10.94 CYP19A1 INHA LHCGR
9
superpathway of steroid hormone biosynthesis 1
Show member pathways
 10.8 CYP17A1 CYP21A2
10
Ovarian steroidogenesis 38
10.71 CYP11A1 CYP17A1 CYP19A1 LHCGR STAR
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GO Terms for Leydig Cell Tumor

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Biological processes related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.83 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 cell-cell signaling GO:0007267 9.69 INHA INSL3 PTHLH
3 steroid metabolic process GO:0008202 9.67 CYP11A1 CYP17A1 CYP21A2
4 male gonad development GO:0008584 9.61 INHA LHCGR STAR
5 SMAD protein signal transduction GO:0060395 9.54 AFP INHA
6 estrogen biosynthetic process GO:0006703 9.48 CYP19A1 STAR
7 C21-steroid hormone biosynthetic process GO:0006700 9.46 CYP11A1 STAR
8 progesterone metabolic process GO:0042448 9.4 AFP CYP17A1
9 cellular response to gonadotropin stimulus GO:0071371 9.37 LHCGR STAR
10 glucocorticoid biosynthetic process GO:0006704 9.33 CYP11A1 CYP17A1 CYP21A2
11 testosterone biosynthetic process GO:0061370 9.32 CYP19A1 STAR
12 cellular response to luteinizing hormone stimulus GO:0071373 9.26 LHCGR STAR
13 sterol metabolic process GO:0016125 9.13 CYP11A1 CYP19A1 CYP21A2
14 steroid biosynthetic process GO:0006694 9.02 CYP11A1 CYP17A1 CYP19A1 CYP21A2 STAR

Molecular functions related to Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.62 CYP11A1 CYP17A1 CYP19A1 CYP21A2
2 heme binding GO:0020037 9.46 CYP11A1 CYP17A1 CYP19A1 CYP21A2
3 hormone activity GO:0005179 9.43 INHA INSL3 PTHLH
4 oxygen binding GO:0019825 9.4 CYP17A1 CYP19A1
5 steroid hydroxylase activity GO:0008395 9.37 CYP19A1 CYP21A2
6 iron ion binding GO:0005506 9.26 CYP11A1 CYP17A1 CYP19A1 CYP21A2
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 8.92 CYP11A1 CYP17A1 CYP19A1 CYP21A2
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Sources for Leydig Cell Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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